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Kanako Sato, Toshiki Endo, Hiroyuki Sakata, Tomoo Inoue, Kuniyasu Niizuma, Teiji Tominaga
The present study reports the case of an 81-year-old woman who underwent lumboperitoneal shunt (LPS) placement for idiopathic normal-pressure hydrocephalus. After LPS placement, the patient presented with radicular pain. A computed tomography scan revealed that the intradural lumbar catheter was tangled at the T11 vertebra; therefore, we decided to remove the catheter under local anesthesia. When 1 cm of the lumbar catheter was withdrawn, the patient suddenly complained of complete loss of bilateral leg sensation and muscle strength...
October 2, 2018: Neurospine
Minou Nirvani, Cuong Khuu, Amela Tulek, Tor Paaske Utheim, Lars Peter Sand, Malcolm L Snead, Amer Sehic
There is little evidence for the involvement of microRNAs (miRNAs) in the regulation of circadian rhythms during enamel development. Few studies have used ameloblast-like cell line LS8 to study the circadian rhythm of gene activities related to enamel formation. However, the transcriptomic analysis of miRNA expression in LS8 cells has not been established yet. In this study, we analyze the oscillations of miRNAs in LS8 cells during one-day cycle of 24 h by next generation deep sequencing. After removal of low quality reads, contaminants, and ligation products, we obtained a high number of clean reads in all 12 samples from four different time points...
December 5, 2018: Gene
Amber M Beynon, Jeffrey J Hebert, Bruce F Walker
Background: Despite widespread use by manual therapists, there is little evidence regarding the reliability of thoracic spine static palpation to test for a manipulable lesion using stiffness or tenderness as diagnostic markers. We aimed to determine the interrater agreement of thoracic spine static palpation for segmental tenderness and stiffness and determine the effect of standardised training for examiners. The secondary aim was to explore expert consensus on the level of segmental tenderness required to locate a "manipulable lesion"...
2018: Chiropractic & Manual Therapies
Nancy D Chiaravalloti, Erica Weber, Glenn Wylie, Trevor Dyson-Hudson, Jill M Wecht
CONTEXT/OBJECTIVE: Cognitive deficits can impact as many as 60% of individuals with spinal cord injury (SCI). In an effort to identify the nature of cognitive deficits in SCI, we examined neuropsychological test performance in individuals with SCI, age matched healthy controls and older healthy controls. DESIGN: Participants completed a motor-free neuropsychological test battery assessing attention, working memory, information processing speed, new learning /memory and executive control...
December 3, 2018: Journal of Spinal Cord Medicine
Gianluca Ardolino, Tommaso Bocci, Martina Nigro, Maurizio Vergari, Alessio Di Fonzo, Sara Bonato, Filippo Cogiamanian, Francesca Cortese, Ilaria Cova, Sergio Barbieri, Alberto Priori
OBJECTIVE: Hereditary spastic paraplegia (HSP) represents a heterogeneous group of neurodegenerative diseases characterized by progressive spasticity and lower limb weakness. We assessed the effects of transcutaneous spinal direct current stimulation (tsDCS) in HSP. DESIGN: A double-blind, randomized, crossover and sham-controlled study. SETTING: Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan. PARTICIPANTS: eleven patients with HSP (six men, mean age ± SD: 37...
December 3, 2018: Journal of Spinal Cord Medicine
Joseph Meyerson, Andrew O'Brien, Nicholas Calvin, Rajiv Chandawarkar
BACKGROUND: Reconstruction of complex back defects, especially after corrective spine surgery, is a challenging problem. In these patients hardware issues predominate and flap failure has serious consequences. Certain subunits of the back pose even greater problems, specifically the central region between T9 and T12. The purpose of this article is to present a novel technique for reconstruction of such spinal defects using a newly described trapezius muscle propeller flap based on the dorsal scapular vessels...
December 3, 2018: Microsurgery
Vladimir Lopez, Elisabeth van der Heijden, Margarita Villar, Anita Michel, Pilar Alberdi, Christian Gortázar, Victor Rutten, José de la Fuente
There is an imperative need for effective control of bovine tuberculosis (BTB) on a global scale and vaccination of cattle may prove to be pivotal in achieving this. The oral and parenteral use of a heat-inactivated Mycobacterium bovis (M. bovis) vaccine has previously been found to confer partial protection against BTB in several species. A role for complement factor C3 has been suggested in wild boar, but the exact mechanism by which this vaccine provides protection remains unclear. In the present study, a quantitative proteomics approach was used to analyze the white blood cell proteome of vaccinated cattle in comparison to unvaccinated controls, prior (T0) and in response to vaccination, skin test and challenge (T9 and T12)...
December 2018: Veterinary Immunology and Immunopathology
Curie Ahn, Eugene Lee, Joon Woo Lee, Choong Guen Chee, Yusuhn Kang, Heung Sik Kang
Spontaneous intracranial hypotension (SIH), caused by CSF leaks, can trigger headaches, and is treated using epidural blood patch (EBP) procedures. We aimed to determine the effectiveness of a newly devised two-site blind EBP procedure as the initial treatment for SIH and compare its effectiveness with that of conventional targeted EBP. We retrospectively reviewed data for 116 patients who underwent EBP for SIH between November 2013 and April 2017. Patients were divided into two groups: those who initially received two-site blind EBP (n = 28) at the cervicothoracic (C7/T1) and thoracolumbar junctions (T12/L1) for sealing CSF leaks at all levels, and those who received targeted EBP after CT myelography (n = 88)...
November 26, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
(no author information available yet)
OBJECTIVEThe surgical correction of adult spinal deformity (ASD) often involves modifying lumbar lordosis (LL) to restore ideal sagittal alignment. However, corrections that include large changes in LL increase the risk for development of proximal junctional kyphosis (PJK). Little is known about the impact of cranial versus caudal correction in the lumbar spine on the occurrence of PJK. The goal of this study was to investigate the impact of the location of the correction on acute PJK development.METHODSThis study was a retrospective review of a prospective multicenter database...
October 1, 2018: Journal of Neurosurgery. Spine
Apisara Chanchotisatien, Jie Xiong, Jintai Yu, Shuguang Chu
BACKGROUND: Primary spinal intramedullary glioblastoma is an extremely rare entity; we report the first case of primary spinal intramedullary glioblastoma presenting with exophytic involvement. The prognosis of glioblastoma remains poor due to the aggressive nature of the disease and lack of effective treatment. CASE DESCRIPTION: A 27-year-old Asian female presented to our hospital with a one-month history of dysuria, incomplete bladder emptying, progressive numbness and weakness of both lower limbs, and a one-year history of back pain...
November 23, 2018: World Neurosurgery
Carole S L Spake, Daniel B C Reid, Alan H Daniels
BACKGROUND: Rapid progression of metastatic non-small cell lung cancer (NSCLC) following discontinuation of tyrosine kinase inhibitors (TKI) or anaplastic lymphoma kinase (ALK) inhibitors has been described and is associated with a poor prognosis. We describe the first reported case of accelerated NSCLC tumor extension throughout the entire spinal epidural space. CASE DESCRIPTION: A 68-year-old woman with stage IV ALK-positive metastatic NSCLC presented with acute neck pain, urinary retention, and lower extremity weakness 15 days following discontinuation of alectinib...
November 23, 2018: World Neurosurgery
Chee Kidd Chiu, Keong Joo Lee, Weng Hong Chung, Josephine Rebecca Chandren, Chris Yin Wei Chan, Mun Keong Kwan
STUDY DESIGN: Retrospective study of a prospectively-collected data. OBJECTIVE: To determine whether the severity of the curve magnitude in Lenke 1 and 2 adolescent idiopathic scoliosis (AIS) patients affects the distance and position of the aorta from the vertebra. SUMMARY OF BACKGROUND DATA: There were studies that looked into the position of the aorta in scoliotic patients but none of them documented the change in distance of the aorta to the vertebra in relation to the magnitude of the scoliosis...
November 20, 2018: Spine
Rebecca L Lambach, Nicole E Stafford, Julie A Kolesar, B Jenny Kiratli, Graham H Creasey, Robin S Gibbons, Brian J Andrews, Gary S Beaupre
OBJECTIVE: To determine the effect of a functional electrical stimulation (FES) rowing program on bone mineral density (BMD) when implemented within two years after SCI. DESIGN: Prospective. SETTING: Health Care Facility. PARTICIPANTS: Convenience sample; four adults with recent (<2 years) traumatic, motor complete SCI (C7-T12 AIS A-B). INTERVENTION: A 90-session FES rowing exercise program; participants attended 30-minute FES training sessions approximately three times each week for the duration of their participation...
November 26, 2018: Journal of Spinal Cord Medicine
Daniela Ghisi, Alessandro Ricci, Sandra Giannone, Tiziana Greggi, Stefano Bonarelli
Background: Acute pancreatitis has been described as potential complication of both abdominal and non-abdominal surgeries. The pathogenetic mechanism underlying acute pancreatitis in spine surgery may include intraoperative hemodynamic instability causing prolonged splanchnic hypoperfusion, as well as mechanical compression of the pancreas due to scoliosis correction, with a higher risk in cases of more extended fusions, especially in young adults with lower body mass index (BMI). Case presentation: We report here a case of postoperative acute pancreatitis with benign evolution in a young female patient after the first and second surgery of a two-stage correction of right thoracic idiopathic scoliosis...
2018: Scoliosis and Spinal Disorders
Paola Bossù, Francesca Salani, Antonio Ciaramella, Eleonora Sacchinelli, Alessandra Mosca, Nerisa Banaj, Francesca Assogna, Maria Donata Orfei, Carlo Caltagirone, Walter Gianni, Gianfranco Spalletta
Alzheimer's disease (AD) is a fatal dementing neurodegenerative disease, currently lacking an efficacious disease-modifying therapy. In the last years, there has been some interest in the use of homotaurine as a potential therapeutic compound for AD, but more work is still needed to prove its efficacy as disease modifier in dementia. Since inflammation is believed to play a key role in AD development, we sought to investigate here the in vivo homotaurine effect on inflammatory response in patients at the earliest stages of AD, i...
2018: Frontiers in Aging Neuroscience
Kayla R Hanson, Wendy A Ware
CASE DESCRIPTION A 9-year-old spayed female Dalmatian was examined because of progressive pelvic limb paraparesis. CLINICAL FINDINGS The dog had a history of chronic urinary incontinence and had been treated with phenylpropanolamine (PPA) for almost 8.5 years. Intervertebral disk disease at T12-13 was diagnosed, and a hemilaminectomy was performed. Three days after surgery, the dog developed a ventricular tachyarrhythmia. Severe left and mild right ventricular hypertrophy were detected by echocardiography. TREATMENT AND OUTCOME The arrhythmia was controlled with sotalol...
December 1, 2018: Journal of the American Veterinary Medical Association
Fatime Hawchar, Ildikó László, Nándor Öveges, Domonkos Trásy, Zoltán Ondrik, Zsolt Molnar
BACKGROUND: The aim of this proof of concept, prospective, randomized pilot trial was to investigate the effects of extracorporeal cytokine removal (CytoSorb®) applied as a standalone treatment in patients with septic shock. METHODS: 20 patients with early (<24 h) onset of septic shock of medical origin, on mechanical ventilation, norepinephrine>10 μg/min, procalcitonin (PCT) > 3 ng/mL without the need for renal replacement therapy were randomized into CytoSorb (n = 10) and Control groups (n = 10)...
February 2019: Journal of Critical Care
Sumei Ren, Ruiqi Liu, Yujie Wang, Ning Ding, Yingxia Li
Ginsenoside Compound K (CK) showed potent activity against IgE for the treatment of asthma. A series of CK analogues were then synthesized by straightforward procedures. The in vivo anti-IgE activity evaluations using the OVA-induced asthmatic mouse model revealed preliminary SARs of the CK analogues, which showed that the sugar type, modifications on A-ring and the C20 side chain of CK all affected much on the activities. Primary SARs optimization led to the discovery of compounds T1, T2, T3, T8 and T12, which displayed superior or comparable anti-asthmatic effects (IgE value = 1237...
November 9, 2018: Bioorganic & Medicinal Chemistry Letters
Zoher Naja, Saleh Kanawati, Ziad El Khatib, Fouad Ziade, Rakan Nasreddine, Ahmad Salah Naja
PURPOSE: The objective of the study was to compare three nerve stimulator-guided paravertebral injections versus five injections for elderly patients undergoing inguinal hernia repair in terms of the amount of intraoperative fentanyl and propofol consumption and conversion to general anesthesia. The secondary objective was postoperative pain. METHODS: A prospective, randomized, double-blind clinical trial was performed. 200 elderly patients undergoing unilateral herniorrhaphy were randomized into two groups...
November 16, 2018: Journal of Anesthesia
N Plataniotis, D S Evangelopoulos, G Katzouraki, S Pneumaticos
PURPOSE: Detailed knowledge of the anatomy of the thoracic aorta is crucial for thoracolumbar spinal surgery. The purpose of the present study is to describe the relative displacement of the aorta to the spine in supine, prone and prone position with padding. Improved understanding of the magnitude and direction of this often-overlooked change could benefit preoperative planning and decision-making. METHODS: A total of 200 patients underwent CT scan of the thoracic spine in the standard supine, prone and prone position with padding...
November 14, 2018: European Spine Journal
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