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Soraya Nishimura, Narihito Nagoshi, Akio Iwanami, Ayano Takeuchi, Takashi Hirai, Toshitaka Yoshii, Kazuhiro Takeuchi, Kanji Mori, Tsuyoshi Yamada, Shoji Seki, Takashi Tsuji, Kanehiro Fujiyoshi, Mitsuru Furukawa, Kanichiro Wada, Masao Koda, Takeo Furuya, Yukihiro Matsuyama, Tomohiko Hasegawa, Katsushi Takeshita, Atsushi Kimura, Masahiko Abematsu, Hirotaka Haro, Tetsuro Ohba, Masahiko Watanabe, Hiroyuki Katoh, Kei Watanabe, Hiroshi Ozawa, Haruo Kanno, Shiro Imagama, Kei Ando, Shunsuke Fujibayashi, Masashi Yamazaki, Kota Watanabe, Morio Matsumoto, Masaya Nakamura, Atsushi Okawa, Yoshiharu Kawaguchi
STUDY DESIGN: This was a retrospective multicenter study. OBJECTIVE: To clarify the progression of diffuse idiopathic skeletal hyperostosis (DISH) using whole-spine computed tomography in patients with cervical ossification of the posterior longitudinal ligament (OPLL). SUMMARY OF BACKGROUND DATA: DISH and cervical OPLL frequently coexist, and can cause ankylosing spinal fractures due to biomechanical changes and fragility of the affected vertebrae...
August 14, 2018: Clinical Spine Surgery
Jill M Wecht, Joseph P Weir, Caitlyn G Katzelnick, Glenn Wylie, Mastanna Eraifej, Nhuguynh Nguyen, Trevor Dyson-Hudson, William A Bauman, Nancy Chiaravalotti
Cognitive deficits are prevalent in the spinal cord injury (SCI) population, and consensus suggests that concomitant traumatic brain injury or co-morbid conditions are primarily responsible for these deficits. However, mounting evidence supports the possibility that systemic and cerebral hemodynamic dysfunction may contribute to the cognitive deficits reported in persons with SCI. We sought to determine the contribution of changes in blood pressure (BP) and changes in cerebral blood flow velocity (CBFv) to test performance on the Symbol Digit Modalities Test (SDMT) in persons with SCI compared to matched nonSCI controls...
August 16, 2018: Journal of Neurotrauma
Phani Krishna Karthik Yelamarthy, Tarush Rustagi, Rajat Mahajan, Vishwajeet Singh, Kalidutta Das, Murari Lal Bansal, Bibhudendu Mohapatra, Harvinder Singh Chhabra
Background: Charcot spinal arthropathy (CSA), a destructive spinal pathology, is seen in patients with impaired sensation. Superimposed infection in the affected spinal segments can lead to a challenge in the diagnosis and management. Spinal cord injury (SCI) is the leading cause of CSA as persons with SCI have significantly impaired sensation. Though infection of the CSA is rare, SCI persons are prone to superimposed infection of the Charcot spine. We report atypical presentations of three cases of CSA with superimposed infection...
2018: Spinal Cord Series and Cases
Qiu-Ju Li, Tong Yu, Lian-Hua Liu, Jian-Wu Zhao
RATIONALE: This study describes the technique of combined Orbic 3D navigation (O3DN) and 3D rapid prototyping (3DRP) to assist surgical correction of congenital scoliosis. PATIENT CONCERNS: A 12-year-old boy with congenital scoliosis. His father brought him to our hospital upon noticing the boy's asymmetry of the trunk. DIAGNOSES: Congenital scoliosis. INTERVENTIONS: O3DN and 3DRP were used to assist correction surgery in this patient...
August 2018: Medicine (Baltimore)
Patrick Ippersiel, Shawn Robbins, Richard Preuss
BACKGROUND: Differences in movement variability may be related to a guarded response to pain or a less robust movement pattern, indicating a potential dysfunction in motor control. The study objective was to compare patterns of lumbo-pelvic coordinative variability, during repeated sit-to-stand-to-sit, in individuals with low back pain and healthy adults. METHODS: Participants were adults with low back pain (n = 16) and healthy controls (n = 21). Kinematics for the T12-L3, L3-S1, and hip segments were measured using electromagnetic motion capture during 10 sit-to-stand-to-sit trials...
July 19, 2018: Clinical Biomechanics
Woo-Keun Kwon, Woong-Bae Park, Gun-Young Lee, Joo Han Kim, Youn-Kwan Park, Hong Joo Moon
OBJECTIVE: We introduce our technique and results of retro-pleural/peritoneal "lateral pediculectomy" for the decompression of thoracolumbar fractures and reconstruction using expandable titanium cage, and circumferential fixation at a single stage. METHODS: 18 patients who had single unstable, burst thoracolumbar fracture were treated by this technique between January 2014 and December 2016 (T12: 9 cases, L1: 7 cases, L2: 2 cases). They were reviewed retrospectively in terms of radiologic (CT scan and X-ray), clinical outcomes and complications...
July 28, 2018: World Neurosurgery
Karlijn H J Groenen, Thom Bitter, Tristia C G van Veluwen, Yvette M van der Linden, Nico Verdonschot, Esther Tanck, Dennis Janssen
Current finite element (FE) models predicting failure behavior comprise single vertebrae, thereby neglecting the role of the posterior elements and intervertebral discs. Therefore, this study aimed to develop a more clinically relevant, case-specific non-linear FE model of two functional spinal units able to predict failure behavior in terms of a) the vertebra predicted to fail; b) deformation of the specimens; c) stiffness; and d) load to failure. For this purpose, we also studied the effect of different bone density-mechanical properties relationships (material models) on the prediction of failure behavior...
July 30, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Ziyu Zhou, Caiyun Hou, Dongdong Li, Jianwei Si
BACKGROUND: Degenerative spondylolisthesis (DS) and lumbar spinal stenosis (LSS) are the most common degenerative spinal diseases. The evaluating of spinopelvic sagittal alignment of the two diseases using pelvic radius (PR) technique have not been reported. The purpose of this study was to use PR measurement technique to compare the differences in spinopelvic sagittal alignment between DS and LSS. METHODS: A total of 145 patients with DS or LSS were retrospectively reviewed...
July 25, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Brian A Derstine, Sven A Holcombe, Brian E Ross, Nicholas C Wang, Grace L Su, Stewart C Wang
Measurements of skeletal muscle cross-sectional area, index, and radiation attenuation utilizing clinical computed tomography (CT) scans are used in assessments of sarcopenia, the loss of skeletal muscle mass and function associated with aging. To classify individuals as sarcopenic, sex-specific cutoffs for 'low' values are used. Conventionally, cutoffs for skeletal muscle measurements at the level of the third lumbar (L3) vertebra are used, however L3 is not included in several clinical CT protocols. Non-contrast-enhanced CT scans from healthy kidney donor candidates (age 18-40) at Michigan Medicine were utilized...
July 27, 2018: Scientific Reports
Peter G Passias, Samantha R Horn, Gregory W Poorman, Alan H Daniels, D Kojo Hamilton, Han Jo Kim, Bassel G Diebo, Leah Steinmetz, Cole A Bortz, Frank A Segreto, Daniel M Sciubba, Justin S Smith, Brian J Neuman, Christopher I Shaffrey, Renaud Lafage, Virginie Lafage, Christopher Ames, Robert Hart, Gregory Mundis, Robert K Eastlack, Frank J Schwab
CD development secondary to PJK was recently documented in adult spinal deformity patients after surgical correction for thoracolumbar ASD. This study analyzes surgical management of patients with CD secondary to proximal junctional kyphosis (PJK) versus patients with primary CD. Retrospective review of multicenter cervical deformity (CD) database. CD defined as at least one of the following: C2-C7 coronal Cobb > 10°, cervical lordosis (CL) > 10°, cervical sagittal vertical axis (cSVA) > 4cm, CBVA > 25°...
July 2, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Christian Liebsch, Nicolas Graf, Hans-Joachim Wilke
The mechanical coupling behaviour of the thoracic spine is still not fully understood. For the validation of numerical models of the thoracic spine, however, the coupled motions within the single spinal segments are of importance to achieve high model accuracy. In the present study, eight fresh frozen human thoracic spinal specimens (C7-L1, mean age 54 ± 6 years) including the intact rib cage were loaded with pure bending moments of 5 Nm in flexion/extension (FE), lateral bending (LB), and axial rotation (AR) with and without a follower load of 400 N...
July 6, 2018: Journal of Biomechanics
Valérie Bissonnette, Bertrand Lussier, Béatrice Doizé, Julie Arsenault
The objective of this study was to evaluate the impact of a trap-neuter-return (TNR) event on the size of free-roaming rural cat colonies in Quebec. This prospective randomized, controlled study included 18 cat colonies around barns and stables that were randomly assigned to either a TNR group (10 colonies of 7 to 27 cats; 14.3 cats on average) or a control group (8 colonies of 7 to 26 cats; 14.5 cats on average). The number of cats in each colony was calculated from the images obtained by camera-trapping at: baseline (T0), 7...
July 2018: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
T S Duffin, S W Thomas
Spinal fracture rates from NAT have been reported in <1-3% of spinal injury cases. We present a 13-month-old female who presented with signs of spinal cord injury and was found to have complete retrospondylolisthesis of T12 vertebra and multiple rib fractures in various stages of healing due to NAT. This case reports an extremely severe spinal injury due to NAT of which there are few in the literature and highlights the importance of suspicion of NAT when pediatric patients present with neurologic symptoms and spinal trauma without plausible mechanism of injury...
2018: Case Reports in Pediatrics
Masashi Miyazaki, Toshinobu Ishihara, Shozo Kanezaki, Naoki Notani, Tetsutaro Abe, Hiroshi Tsumura
OBJECTIVE: We aimed to investigate the relative preoperative position of the spinal cord in AIS and explore the potential risk of spinal cord injury from placement of pedicle screws. PATIENTS AND METHODS: Twenty-seven patients with a mean age of 15 ± 1.8 years (range, 12-19 years) classified as having Lenke type 1 AIS (1A: 15 cases, 1B: 8 cases, 1C: 4 cases) were analyzed. The mean Cobb angle of the main curve was 55.9 ± 14.4°. Axial CT myelography images were selected from the T4 to T12 vertebrae, and 243 images were analyzed...
July 10, 2018: Clinical Neurology and Neurosurgery
Jian Zhao, Jianping Fan, Yuanyuan Chen, Changwei Yang, Gengwu Li, Ming Li
To compare the characteristics of Cobb angle distribution of the main thoracic curve (MTC) in patients with Lenke 1 adolescent idiopathic scoliosis (AIS) and differences in fulcrum-bending flexibility, correction rate, and correction index between different segments.Included in this study were 40 consecutive patients with Lenke 1 AIS who received posterior correction and fusion with pedicle screws. Cobb angle based on the proximal (T5-T7 or T6-T8), apical (T7-T9 or T8-T10), and distal (T9-T11 or T10-T12) segments in the fulcrum-bending position was measured before and after surgery...
July 2018: Medicine (Baltimore)
Kati Kristiina Kyrölä, Järvenpää Salme, Järviluoma Tuija, Irmola Tero, Kauppinen Eero, Häkkinen Arja
Objective: To evaluate the intra- and interrater reliability (I-IR) of sagittal spinopelvic parameters from digital full-spine plain radiographs with basic software tools in an unselected adult population with degenerative spinal complaints who were evaluated for surgery. Methods: Forty-nine adult full-spine digital radiographs were measured twice by 3 independent observers, including an experienced spine surgeon, an experienced radiologist, and a resident orthopedic surgeon...
June 2018: Neurospine
Yi Liu, John A Carrino, Alexander S Dash, Tariq Chukir, Huong Do, Richard S Bockman, Alexander P Hughes, Joel M Press, Emily M Stein
Context: Epidural steroid injections (ESI) are a common, effective treatment for lumbar radiculopathy and sciatica. While the negative skeletal effects of oral glucocorticoids are well established, little is known about the impact of ESI on bone quality. DXA is subject to artifact in patients with spine pathology and may have limited utility in this population. Objective: To investigate the relationship between ESI exposure and volumetric bone density (vBMD) at the lumbar spine (LS) using central quantitative CT (cQCT)...
July 2, 2018: Journal of Clinical Endocrinology and Metabolism
Inese Gavarāne, Jūlija Trofimova, Artjoms Mališevs, Olga Valciņa, Muza Kirjušina, Ilze Rubeniņa, Aivars Bērziņš
Acanthamoeba are free-living amoebae found in various ecological environments, and they are major microbial predators. Some Acanthamoeba species can cause keratitis, granulomatous amoebic encephalitis, and infections of the organs. This is the first study in Latvia describing Acanthamoeba detection by molecular techniques and genotyping using tap water from different sources. An 18S rRNA gene investigation of the 20 Acanthamoeba isolates suggested that 19 belonged to the hazardous T4 genotype and one sample was T12...
July 5, 2018: Parasitology Research
Patrick J Gorden, Joshua A Ydstie, Michael D Kleinhenz, Troy A Brick, Joe S Smith, Ronald W Griffith, Larry W Wulf, Suzanne M Rajewski, Min Zhang, Pritam K Sidhu, Jonathan P Mochel, Johann F Coetzee
Ceftiofur (CEF) is a third-generation cephalosporin that is the most widely used antimicrobial in the dairy industry. Currently, violative meat residues in cull dairy cattle are commonly associated with CEF. One potential cause for violative residues is altered pharmacokinetics of the drug due to disease, which could increase the time needed for the residue to deplete. The objectives of this study were (a) to determine the absolute bioavailability of CEF crystalline-free acid (CFA) in healthy versus diseased cows; (b) to compare the plasma and interstitial fluid pharmacokinetics and plasma protein binding of CEF between healthy dairy cows and those with disease; and (c) to determine the CEF residue profile in tissues of diseased cows...
July 4, 2018: Journal of Veterinary Pharmacology and Therapeutics
Gianluca Trevisi, Alba Scerrati, Elisabetta Peppucci, Chiara DeWaure, Carmelo Anile, Annunziato Mangiola
BACKGROUND: Mild traumatic brain injury (MTBI) is among the most common causes of emergency admission. Current guidelines have clearly evidenced risk factors and neurologic signs that should suggest computed tomography (CT) of the head at admission and indications for the first repeated CT scan. However, the role and frequency of further repeated CT scans after an initially positive scan are still unclear. METHODS: We retrospectively analyzed 222 patients admitted in our hospital for clinical observation after an MTBI and a positive initial scan...
June 30, 2018: World Neurosurgery
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