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Premenopausal osteoporosis

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https://www.readbyqxmd.com/read/27846926/low-dairy-calcium-intake-is-associated-with-overweight-and-elevated-blood-pressure-in-polish-adults-notably-in-premenopausal-women
#1
Elżbieta Skowrońska-Jóźwiak, Maciej Jaworski, Roman Lorenc, Małgorzata Karbownik-Lewińska, Andrzej Lewiński
OBJECTIVE: Dietary Ca is now being recognized to play an important role not only in skeletal integrity, but also in the regulation of energy and metabolism. The aim of the present study was to estimate the relationship of dairy Ca intake with BMI and blood pressure (BP) in a sample derived from the Polish population. DESIGN: Ca intake was calculated from an interviewer-administered semi-quantitative FFQ. BMI was calculated from measured weight and height, and BP was measured by a physician...
November 16, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27834082/association-between-obesity-and-bone-mineral-density-by-gender-and-menopausal-status
#2
Mohammad Reza Salamat, Amir Hossein Salamat, Mohsen Janghorbani
BACKGROUND: We investigated whether there were gender differences in the effect of obesity on bone mineral density (BMD) based on menopausal status. METHODS: We assessed 5,892 consecutive patients 20 to 91 years old who were referred for dual-energy X-ray absorptiometry (DXA) scans. All subjects underwent a standard BMD scan of the hip (total hip and femoral neck) and lumbar spine (L1 to L4) using a DXA scan and body size assessment. Body mass index was used to categorize the subjects as normal weight, overweight, and obese...
November 4, 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27825568/osteoarticular-manifestations-of-celiac-disease-and-non-celiac-gluten-hypersensitivity
#3
Stéphanie Dos Santos, Frédéric Lioté
Celiac disease is a chronic inflammatory autoimmune enteropathy based disorder that is triggered by the ingestion of gluten in genetically susceptible individuals. The global prevalence of 1% to 2% represents only the tip of the iceberg. The diagnosis is confirmed by positive specific antibody, anti-transglutaminase or anti-endomysium, specific lesions of the small intestine and a response to strict gluten-free diet. The diagnosis is difficult and often delayed because the clinical variability is very large, ranging from digestive clinical presentation "classic" to "atypical" symptoms, often extra-intestinal, that are sometimes attributed to a concomitant disease or a complication...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27821086/antineoplastic-treatment-effect-on-bone-mineral-density-in-mexican-breast-cancer-patients
#4
Karina Monroy-Cisneros, Julián Esparza-Romero, Mauro E Valencia, Alfonso G Guevara-Torres, Rosa O Méndez-Estrada, Iván Anduro-Corona, Humberto Astiazarán-García
BACKGROUND: Breast cancer is the most deadly malignancy in Mexican women. Although treatment has improved, it may significantly affect bone mineral status in those who receive it. The aim of this study was to assess the impact of cancer treatment on bone mineral density (BMD) and bone mineral content (BMC), in patients with breast cancer and explore the interaction of menopausal status and clinical stage with cancer treatment on such changes. METHODS: A quasi-experimental design was applied with measurements before and after a chemotherapy treatment in 40 patients with primary diagnosis of invasive breast cancer...
November 8, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27802892/osteoporosis-management-in-patients-with-breast-cancer-emas-position-statement
#5
REVIEW
Florence A Trémollieres, Iuliana Ceausu, Herman Depypere, Irene Lambrinoudaki, Alfred Mueck, Faustino R Pérez-López, Yvonne T van der Schouw, Levent M Senturk, Tommaso Simoncini, John C Stevenson, Petra Stute, Margaret Rees
Aromatase inhibitors (AIs) are the first-line recommended standard of care for postmenopausal estrogen receptor-positive breast cancer. Because they cause a profound suppression of estrogen levels, concerns regarding their potential to increase the risk of fracture were rapidly raised. There is currently a general consensus that a careful baseline evaluation is needed of the risk of fracture in postmenopausal women about to start treatment with AIs but also in all premenopausal women with early disease. Bisphosphonates have been shown in several phase III trials to prevent the bone loss induced by cancer treatment, although no fracture data are available...
January 2017: Maturitas
https://www.readbyqxmd.com/read/27793381/hormone-replacement-therapy-in-young-women-with-surgical-primary-ovarian-insufficiency
#6
REVIEW
Philip M Sarrel, Shannon D Sullivan, Lawrence M Nelson
Bilateral oophorectomy performed in women before they are menopausal induces surgical primary ovarian insufficiency, an acute and chronic deficiency of the hormones normally produced by the ovaries. Without hormone replacement therapy (HRT) most of these women develop severe symptoms of estrogen (E) deficiency and are at increased risk for osteoporosis, cardiovascular disease, cognitive decline, dementia, and the associated increases in morbidity and mortality. In cases in which a hysterectomy has been performed at the time of bilateral oophorectomy transdermal or transvaginal E2 replacement therapy without cyclic progestin replacement is the optimum hormonal management for these women...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27764963/the-relationship-between-osteoporosis-and-body-composition-in-pre-and-postmenopausal-women-from-different-ethnic-groups-in-china
#7
Dan Mo, Peishan Hsieh, Hongrong Yu, Lining Zhou, Jichun Gong, Lin Xu, Peng Liu, Gang Chen, Zhao Chen, Qiongying Deng
OBJECTIVE: To investigate the ethnic differences in osteoporosis (OP) and body composition (BC) and their relationship in the Maonan, Mulam, Hmong, and Yao minorities in China. DESIGN: A total of 860 Maonan, Mulam, Hmong, and Yao women were included in this cross-sectional study. Demographic, health history, and lifestyle information was collected using questionnaires. BC was measured through bioelectrical impedance analysis, and bone mineral density (BMD) was assessed via calcaneal quantitative ultrasound...
October 21, 2016: Ethnicity & Health
https://www.readbyqxmd.com/read/27732325/stress-fractures-concepts-and-therapeutics
#8
Carolina A Moreira, John P Bilezikian
CONTEXT: Stress fractures are repetitive use injuries in which recurrent strains lead to material fatigue and microarchitectural discontinuities. Stress fractures account for up to 20% of athletic injuries, more commonly sustained by women and in those who engage in track-and-field events. The pathogenesis of stress fractures is multifactorial. Although most stress fracture are reported among women who may experience menstrual disturbances, low body mass index, low energy intake and sometimes low bone mass, these individuals do not regularly seek endocrinological attention...
October 12, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27693001/accelerated-accumulation-of-multimorbidity-after-bilateral-oophorectomy-a-population-based-cohort-study
#9
Walter A Rocca, Liliana Gazzuola-Rocca, Carin Y Smith, Brandon R Grossardt, Stephanie S Faubion, Lynne T Shuster, James L Kirkland, Elizabeth A Stewart, Virginia M Miller
OBJECTIVE: To study the association between bilateral oophorectomy and the rate of accumulation of multimorbidity. PATIENTS AND METHODS: In this historical cohort study, the Rochester Epidemiology Project records-linkage system was used to identify all premenopausal women who underwent bilateral oophorectomy before age 50 years between January 1, 1988, and December 31, 2007, in Olmsted County, Minnesota. Each woman was randomly matched to a referent woman born in the same year (±1 year) who had not undergone bilateral oophorectomy...
November 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27661794/rivaroxaban-significantly-inhibits-the-stimulatory-effects-of-bone-modulating-hormones-in-vitro-study-of-primary-female-osteoblasts
#10
Dalia Somjen, Zachary T Sharfman, Sara Katzburg, Orli Sharon, Eran Maman, Moshe Salai, Naftali Stern, Oleg Dolkart
BACKGROUND: Anticoagulant therapy is a mainstay of treatment subsequent to major orthopedic surgeries. Evidence linking anticoagulant therapy, osteoporosis, and delayed fracture healing is not conclusive. We have previously reported that rivaroxaban significantly inhibited cell growth and energy metabolism in a human osteoblastic cell line. This study analyzed the response of primary female osteoblast cells to rivaroxaban in combination with various bone-modulating hormones. METHODS: Bone samples were taken from both premenopausal (pre-Ob) and postmenopausal (post-Ob) women...
August 11, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27660876/influence-of-dietary-calcium-intake-on-quantitative-and-qualitative-parameters-of-bone-tissue-in-polish-adults
#11
Elżbieta Skowrońska-Jóźwiak, Maciej Jaworski, Roman Lorenc, Andrzej Lewiński
INTRODUCTION: The objective of the study was to assess dietary calcium intake in the Polish population and its influence on selected parameters of bone tissue. MATERIALS AND METHOD: 1,129 osteoporosis treatment-naive subjects, aged 20-80 years, randomly selected, were involved in the study. Bone status was established using densitometry of spine and hip and quantitative ultrasound of the calcaneus. Dietary calcium intake was calculated according to data gathered in a questionnaire...
September 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/27614458/association-between-omentin-1-adiponectin-and-bone-health-under-consideration-of-osteoprotegerin-as-possible-mediator
#12
J Menzel, R Di Giuseppe, R Biemann, K Aleksandrova, O Kuxhaus, C Wittenbecher, A Fritsche, M B Schulze, B Isermann, H Boeing, C Weikert
PURPOSE: Several studies implicated a crosstalk between bone and fat in the pathogenesis of osteoporosis. Few studies indicated an association between adiponectin and omentin-1 on the bone remodeling process and bone mineral density, and suggested osteoprotegerin (OPG) as a mediator of this relationship. However, only limited evidence on this relationship is available in humans. Therefore, this study aimed to investigate the association between omentin-1, adiponectin and broadband ultrasound attenuation (BUA) in peri-/premenopausal and postmenopausal women, and to assess the role of OPG as a possible mediator...
November 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27608794/the-negative-bone-effects-of-the-disease-and-of-chronic-corticosteroid-treatment-in-premenopausal-women-affected-by-rheumatoid-arthritis
#13
A Fassio, L Idolazzi, M A Jaber, C Dartizio, O Viapiana, M Rossini, D Gatti
Osteoporosis is a well-known extra-articular complication in rheumatoid arthritis (RA). The chronic corticosteroid treatment, the functional impairment associated with RA and the disease itself appear to be the most relevant determinants. Most of the previous studies involved postmenopausal women, in whom the estrogenic deficiency might amplify the negative effect towards bone of both RA and corticosteroid therapy. We decided to evaluate bone health in a cohort of premenopausal RA patients. The study population includes 47 premenopausal women attending our outpatient clinic for RA and twice as many healthy age-matched control women selected from the hospital personnel...
September 9, 2016: Reumatismo
https://www.readbyqxmd.com/read/27583816/raloxifene-hydrochloride-for-breast-cancer-risk-reduction-in-postmenopausal-women
#14
Nicoletta Provinciali, Chen Suen, Barbara K Dunn, Andrea DeCensi
INTRODUCTION: Raloxifene is an estrogen receptor modulator which competes with estrogens for binding to the estrogen receptor . Based on the results of the STAR (Study of Tamoxifen And Raloxifene) trial, raloxifene has been approved by the U.S. Food and Drug Administration for the reduction of breast cancer (BC) risk in postmenopausal women at increased risk. AREAS COVERED: This analysis reviews the activity of raloxifene and the clinical trials for non-BC indications which led to investigate its use as BC preventive agent...
September 1, 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27552543/circulating-microrna-signatures-in-patients-with-idiopathic-and-postmenopausal-osteoporosis-and-fragility-fractures
#15
Roland Kocijan, Christian Muschitz, Elisabeth Geiger, Susanna Skalicky, Andreas Baierl, Rainer Dormann, Fabian Plachel, Xaver Feichtinger, Patrick Heimel, Astrid Fahrleitner-Pammer, Johannes Grillari, Heinz Redl, Heinrich Resch, Matthias Hackl
CONTEXT: Established bone turnover markers (BTM) do not reflect fracture risk in idiopathic male and premenopausal osteoporosis and the role of microRNAs (miRNAs) in these patients is currently unclear. miRNAs are a class of small non-coding RNAs that regulate gene expression and bone tissue homeostasis. They are considered a new class of endocrine regulators with promising potential as biomarkers. OBJECTIVE: Evaluation of circulating miRNA signatures in male and female subjects with idiopathic and postmenopausal osteoporotic low-traumatic fractures...
August 23, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27535783/the-effect-of-bisphosphonate-treatment-on-osteoclast-precursor-cells-in-postmenopausal-osteoporosis-the-trio-study
#16
F Gossiel, C Hoyle, E V McCloskey, K E Naylor, J Walsh, N Peel, R Eastell
Bisphosphonates are used to treat bone disease characterised by increased bone resorption by inhibiting the activity of mature osteoclasts, resulting in decreased bone turnover. Bisphosphonates may also reduce the population of osteoclast precursor cells. Our aims were to investigate the effect of bisphosphonates on i) osteoclast precursor cells and ii) circulating cytokine and cytokine receptor in postmenopausal women with osteoporosis compared with healthy premenopausal women. Participants were 62 postmenopausal women (mean age 66) from a 48-week parallel group trial of bisphosphonates...
November 2016: Bone
https://www.readbyqxmd.com/read/27503170/associations-of-dietary-calcium-intake-with-metabolic-syndrome-and-bone-mineral-density-among-the-korean-population-knhanes-2008-2011
#17
M K Kim, S J Chon, E B Noe, Y H Roh, B H Yun, S Cho, Y S Choi, B S Lee, S K Seo
: Excessive amount of calcium intake increased risk for metabolic syndrome in men. However, modest amount decreased the risk of metabolic syndrome and osteoporosis in postmenopausal women. Modest amount of calcium also increased bone mineral density (BMD) in both men and postmenopausal women. INTRODUCTION: The present study aimed to evaluate the associations of dietary calcium intake with metabolic syndrome and bone mineral density (BMD) in Korean men and women, especially postmenopausal women...
August 8, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27476376/serum-cx3cl1-fractalkine-concentrations-are-positively-associated-with-disease-severity-in-postmenopausal-osteoporotic-patients
#18
Yi-Ding Chen, Ci-You Huang, Hai-Ying Liu, Wei-Feng Yao, Wei-Guo Wu, Yu-Lian Lu, Wen Wang
BACKGROUND: The chemokine (C-X3-C motif) ligand 1 (CX3CL1), also called fractalkine (FKN), has recently been reported to be involved in osteoclastogenic process and pathological bone destruction. OBJECTIVE: This study aimed to investigate the link between serum CX3CL1/FKN levels with disease progression of postmenopausal osteoporotic patients. METHODS: A total of 53 women with postmenopausal osteoporosis (PMOP group), 51 postmenopausal non-osteoporotic female patients (PMNOP group) and 50 premenopausal non-osteoporotic healthy women of childbearing age (control group) were enrolled in the study...
July 2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27357175/bone-mineral-density-is-positively-related-to-carotid-intima-media-thickness-findings-from-a-population-based-study-in-adolescents-and-premenopausal-women
#19
Monika Frysz, Kevin Deere, Debbie A Lawlor, Li Benfield, Jon H Tobias, Celia L Gregson
Osteoporosis and cardiovascular disease (CVD) are both common causes of morbidity and mortality. Previous studies, mainly of people older than 60 years, suggest a relationship between these conditions. Our aim was to determine the association between bone characteristics and CVD markers in younger and middle-aged individuals. Women (n = 3366) and their adolescent offspring (n = 4368) from the UK population-based cohort study, Avon Longitudinal Study of Parents and Children (ALSPAC), were investigated...
December 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27342884/compounds-of-natural-origin-and-acupuncture-for-the-treatment-of-diseases-caused-by-estrogen-deficiency
#20
REVIEW
Abhishek Thakur, Subhash C Mandal, Sugato Banerjee
A predominant number of diseases affecting women are related to female hormones. In most of the cases, these diseases are reported to be associated with menstrual problems. These diseases affect female reproductive organs such as the breast, uterus, and ovaries. Estrogen is the main hormone responsible for the menstrual cycle, so irregular menstruation is primarily due to a disturbance in estrogen levels. Estrogen imbalance leads to various pathological conditions in premenopausal women, such as endometriosis, breast cancer, colorectal cancer, prostate cancer, poly cysts, intrahepatic cholestasis of pregnancy, osteoporosis, cardiovascular diseases, obesity, etc...
June 2016: Journal of Acupuncture and Meridian Studies
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