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Premenopausal osteoporosis

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https://www.readbyqxmd.com/read/29422346/bone-loss-in-women-with-brca1-and-brca2-mutations
#1
C Bethan Powell, Amy Alabaster, Nicole Stoller, Mary Anne Armstrong, Chelsea Salyer, Isabella Hamilton, Tina Raine-Bennett
OBJECTIVE: Estimate the prevalence and identify risk factors for bone loss in women with BRCA mutations. METHODS: Women, age 40 and older, with BRCA mutations identified from the Breast Cancer Surveillance database at Kaiser Permanente Northern California were invited to participate and undergo a dual-energy x-ray absorptiometry scan to assess for bone loss (osteopenia or osteoporosis). Multivariable logistic regression analysis was performed to assess clinical factors associated with bone loss...
February 5, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29398856/comparison-of-bone-mineral-density-among-pre-and-post-menopausal-women-with-and-without-chronic-generalized-periodontitis
#2
Priyadarshini Ramasubramanian Svedha, Jaideep Mahendra, Ramakrishnan Theayarajar, Ambalavanan Namachivayam
Background: There have been a very limited number of studies regarding the assessment of bone mineral density (BMD) using dual energy X-ray absorptiometry scan. Hence, the purpose of the study was to assess the relationship between BMD and periodontal health in three different study groups. Materials and Methods: The study comprised of thirty female individuals who were categorized into three groups: ten premenopausal women with healthy periodontium (Group A), ten premenopausal women with generalized chronic periodontitis (Group B), and ten postmenopausal women with generalized chronic periodontitis (Group C)...
March 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29348519/guanylate-binding-protein-1-inhibits-osteogenic-differentiation-of-human-mesenchymal-stromal-cells-derived-from-bone-marrow
#3
Shi Bai, Zhixiang Mu, Yuanding Huang, Ping Ji
Guanylate Binding Proteins (GBPs) are a group of cytokine-inducible large guanosine triphosphatase. Previous studies have shown high expression of GBP1 in circulating monocytes of premenopausal subjects was correlated to extremely low peak bone mass, which is considered as an important determinant of osteoporosis. However, whether GBPs play a role in regulation of osteogenesis of mesenchymal stromal cells (MSCs) remains largely unknown. In the present study, we found that mRNA expression of GBP1 was highest among all the GBPs, and it was dramatically downregulated during osteogenic differentiation of human MSCs derived from bone marrow (hBM-MSCs)...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29246678/individualized-fracture-risk-feedback-and-long-term-benefits-after-10-years
#4
Feitong Wu, Karen Wills, Laura L Laslett, Malcolm D Riley, Brian Oldenburg, Graeme Jones, Tania Winzenberg
INTRODUCTION: This study aimed to determine if beneficial effects of individualized feedback of fracture risk on osteoporosis preventive behaviors and bone mineral density observed in a 2-year trial were sustained long-term. METHODS: This was a 10-year follow-up of a 2-year RCT in 470 premenopausal women aged 25-44 years, who were randomized to one of two educational interventions (the Osteoporosis Prevention and Self-Management Course [OPSMC] or an osteoporosis information leaflet) and received tailored feedback of their relative risk of fracture in later life (high versus normal risk groups)...
December 12, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29177573/triptorelin-a-review-of-its-use-as-an-adjuvant-anticancer-therapy-in-early-breast-cancer
#5
James E Frampton
A 1-month formulation of the gonadotrophin-releasing hormone agonist (GnRHa) triptorelin (Decapeptyl®) has been approved in the EU as an adjuvant treatment in combination with tamoxifen or an aromatase inhibitor (AI), of endocrine-responsive, early-stage breast cancer in women at high risk of recurrence who are confirmed as premenopausal after completion of chemotherapy. This indication reflects the results of the 5-year SOFT and TEXT studies, especially SOFT, in which ovarian function suppression (OFS; mainly achieved with triptorelin) added to tamoxifen provided a significant benefit in the overall study population of premenopausal patients only after adjusting for prognostic factors...
December 2017: Drugs
https://www.readbyqxmd.com/read/29168740/dietary-intake-of-cadmium-lead-and-mercury-and-its-association-with-bone-health-in-healthy-premenopausal-women
#6
Jesus M Lavado-García, Luis M Puerto-Parejo, Raul Roncero-Martín, Jose M Moran, Juan D Pedrera-Zamorano, Ignacio J Aliaga, Olga Leal-Hernández, Maria L Canal-Macias
The bone is one of the relevant target organs of heavy metals, and heavy metal toxicity is associated with several degenerative processes, such osteoporosis and bone mineral alterations, that could lead to fractures. We aimed to study a presumed relationship between bone density, evaluated by quantitative bone ultrasound (QUS), dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) and the dietary intake of cadmium, lead and mercury in healthy premenopausal women. A total of 158 healthy, non-smoking, premenopausal women were incorporated into the study...
November 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29123427/effect-of-age-and-estrogen-on-biochemical-markers-of-bone-turnover-in-postmenopausal-women-a-population-based-study-from-nepal
#7
Bashu Dev Pardhe, Sabala Pathak, Anjeela Bhetwal, Sumitra Ghimire, Shreena Shakya, Puspa Raj Khanal, Sujan Babu Marahatta
Background: Osteoporosis, a common disease worldwide, is characterized by low bone mass and architectural deterioration of bone tissue, leading to enhanced bone fragility and increase in fracture risks. Both menopause and aging are related factors leading to greater risk of bone disease, particularly among postmenopausal women. Hence, the main purpose of this study was to investigate the differences in biochemical markers of bone turnover and to evaluate the association of hormones and age-related factors with biochemical markers between pre- and postmenopausal women...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29117613/evaluation-of-the-relation-between-omentin-1-and-vitamin-d-in-postmenopausal-women-with-or-without-osteoporosis
#8
O Dikker, S Bekpinar, Gul Ozdemirler, Mujdat Uysal, Muberra Vardar, Sevgi Atar, Murat Usta, Berrin Huner
Introduction Crosstalk between bone and adipose tissues is implicated in several pathologic conditions related to bone metabolism. Omentin-1, a 34-kD protein, is released from omental adipose tissue. A few studies indicated the effect of omentin-1 on bone health and bone mineral density (BMD) and the interaction of omentin-1 with vitamin D. Therefore, this study aimed to investigate the relationship between omentin-1, vitamin D, and BMD in postmenopausal women with osteoporosis compared with non-osteoporotic counterparts...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29018923/is-drug-induced-bone-loss-acceptable-in-premenopausal-women-a-practical-fracture-risk-modeling-exercise
#9
N Binkley, R Besuyen, T Fuerst, L Skillern, D Hans
Premenopausal bone loss increases fracture risk later in life. Depending on peak values, varying degrees of bone mass and microarchitectural loss can be tolerated. We suggest that risk-benefit assessments of drugs that cause premenopausal bone loss be individualized considering baseline status and subsequent BMD and TBS loss. INTRODUCTION: It is logical that drug-induced loss of bone mass and microarchitecture in young adults increase fracture risk later in life. However, no existing data quantify how drug-induced bone loss in younger adults impacts fracture risk later in life...
December 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28965212/subsequent-fracture-risk-of-women-with-pregnancy-and-lactation-associated-osteoporosis-after-a-median-of-6%C3%A2-years-of-follow-up
#10
I Kyvernitakis, T C Reuter, L Hellmeyer, O Hars, P Hadji
Almost a quarter of patients with PAO will sustain a subsequent fracture; patients need to be informed about potential risks before deciding for further pregnancies. INTRODUCTION: Pregnancy and lactation-associated osteoporosis (PAO) is a severe type of premenopausal osteoporosis which predominantly occurs in the last trimester of pregnancy or immediately postpartum. Long-term follow-up data including subsequent fracture risk have yet to be reported. METHODS: This single-center prospective cohort study investigated the subsequent fracture risk of all 107 patients with PAO who were referred to our institution...
September 30, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28955692/association-between-hemoglobin-level-and-bone-mineral-density-in-korean-adults
#11
Yun Hwan Oh, Ji Hyun Moon, Belong Cho
BACKGROUND: Low bone mineral density (BMD) increases fracture risk. Anemia is highly prevalent. Some studies suggested that anemia is an independent risk factor for osteoporosis. The aim of this study was to evaluate the association between hemoglobin (Hb) level and BMD in Korean adults. METHODS: This study was based on data from the Korea National Health and Nutrition Examination Survey 2008 to 2011. Propensity score-matching was performed to establish a dataset for analysis...
August 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28943183/quantitative-ultrasound-of-the-mandible-as-a-novel-screening-approach-for-osteoporosis
#12
Anna Beattie, Seán Cournane, Ciarán Finucane, J Bernard Walsh, Leo F A Stassen
This study used an axial transmission quantitative ultrasound (QUS) device to assess mandibular bone strength. The aim of the study was first to establish the precision and repeatability of the axial transmission QUS measurement for a range of mandibular anatomic sites, and second to investigate the ability of the modality to differentiate between osteoporotic subjects and a control group. Three groups of adult Caucasian women were recruited: (1) healthy premenopausal women (n = 26), (2) healthy postmenopausal women (n = 48), and (3) women with osteoporosis (n = 53)...
September 21, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28886822/osteopenia-and-osteoporosis-in-female-athletes
#13
REVIEW
John M MacKnight
Disorders of bone density are especially prevalent among athletic women. The severity of bone loss ranges from osteopenia to frank osteoporosis. In female athletes, a higher incidence of osteoporosis is due to a decreased rate of bone accretion in youth, often as a result of hormonal deficiency and/or excessive exercise. Low bone mass poses a particular challenge for athletes because it predisposes to stress-related bone injuries and increases the risk of osteoporosis and insufficiency fractures with aging...
October 2017: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/28860420/baseline-mineralizing-surface-determines-the-magnitude-of-the-bisphosphonate-effect-on-cortical-bone-mineralization-in-postmenopausal-osteoporotic-patients
#14
B M Misof, S Blouin, S Lueger, E P Paschalis, R R Recker, R Phipps, K Klaushofer, P Roschger
PURPOSE: To determine the effect of short- or long-term bisphosphonate treatment on cortical bone mineralization density distribution (BMDD). METHODS: BMDD was assessed by quantitative backscatter electron imaging in postmenopausal osteoporosis: in paired transiliac biopsy samples (n=36) at baseline and after 3 years risedronate treatment from a clinical study, in transiliac biopsy samples from patients who were treated with either risedronate (n=31) or alendronate (n=68) for 3 to 7 years from an observational study...
September 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28838807/skeletal-health-in-breast-cancer-survivors
#15
REVIEW
Olivier Bruyère, Pierre Bergmann, Etienne Cavalier, Evelien Gielen, Stefan Goemaere, Jean-Marc Kaufman, Serge Rozenberg, Jean-Jacques Body
Although some risk factors for breast cancer might be protective for osteoporosis, several cross-sectional studies have reported, nevertheless, that patients with breast cancer have a lower bone mass and potentially a higher incidence of fractures than expected. In any case, it appears that patients with breast cancer are not protected from osteoporosis, which provides further support for the recommendation that bone health is assessed after a diagnosis of breast cancer. Most adjuvant therapies will lead to increased bone loss and a higher fracture rate...
November 2017: Maturitas
https://www.readbyqxmd.com/read/28662191/relationship-between-bone-mineral-density-and-alcohol-intake-a-nationwide-health-survey-analysis-of-postmenopausal-women
#16
Hae-Dong Jang, Jae-Young Hong, Kyungdo Han, Jae Chul Lee, Byung-Joon Shin, Sung-Woo Choi, Seung-Woo Suh, Jae-Hyuk Yang, Si-Young Park, Chungwon Bang
OBJECTIVES: Among a variety of relevant factors of osteoporosis, the association between alcohol intake and postmenopausal women's bone mineral density (BMD) by using data from the Korean National Health and Nutrition Examination Survey was evaluated in this study. MATERIALS AND METHODS: Among a total of 31,596 subjects, males, premenopausal women, participants without BMD data were excluded. Finally, a total number of subjects in the study was 3,312. The frequency and amount of alcohol intake were determined by self-reported questionnaires, and BMD was measured by dual-energy x-ray absorptiometry...
2017: PloS One
https://www.readbyqxmd.com/read/28660495/determinants-of-bone-mineral-density-in-young-australian-women-results-from-the-safe-d-study
#17
E T Callegari, S M Garland, A Gorelik, J D Wark
The study aimed to explore determinants of bone parameters in young women. Most bone parameters were associated with height and lean mass. Bone parameters were not associated with vitamin D status. Future research should address whether interventions aimed at improving lean mass are beneficial to bone health in young women. INTRODUCTION: The implementation of prevention strategies during young adulthood may be crucial for osteoporosis prevention in later life, yet literature examining the determinants of bone health in premenopausal women is limited...
June 28, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28566852/correlation-of-mandibular-radiomorphometric-indices-with-serum-calcium-and-serum-estradiol-in-pre-and-post-menopausal-women
#18
Lina Govind Chandak, Vidya Krushnarao Lohe, Rahul R Bhowate, Krushna P Gandhi, Neha V Vyas
BACKGROUND: Osteoporosis is a disease that is seen commonly with increasing age. The purpose of this study was to compare the bone quality of pre- and post-menopausal women using the quantitative indices determined by measurements on panoramic radiographs (mental index, inferior and superior panoramic mandibular indices, antegonion index [AGI], and gonion index) and to determine the effects of serum calcium and serum estradiol levels on alveolar bone loss. MATERIALS AND METHODS: Sixty female patients in the age group of 25-55 years were included in the study...
January 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/28509627/impact-of-risk-reducing-salpingo-oophorectomy-in-premenopausal-women
#19
R F M Vermeulen, M van Beurden, C M Korse, G G Kenter
OBJECTIVES: To describe implications of premenopausal risk-reducing salpingo-oophorectomy (RRSO) on quality of life, endocrine symptoms, sexual function, osteoporosis, cardiovascular health, metabolic syndrome, cognitive impairment and safety of hormone replacement therapy. METHODS: We searched the following electronic databases: The Cochrane Library, EMBASE, PsycInfo, and MEDLINE. We selected controlled and uncontrolled trials of premenopausal women undergoing RRSO...
June 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28490509/vitamin-d-and-calcium-intake-and-risk-of-early-menopause
#20
Alexandra C Purdue-Smithe, Brian W Whitcomb, Kathleen L Szegda, Maegan E Boutot, JoAnn E Manson, Susan E Hankinson, Bernard A Rosner, Lisa M Troy, Karin B Michels, Elizabeth R Bertone-Johnson
Background: Early menopause, defined as the cessation of ovarian function before the age of 45 y, affects ∼10% of women and is associated with higher risk of cardiovascular disease, osteoporosis, and other conditions. Few modifiable risk factors for early menopause have been identified, but emerging data suggest that high vitamin D intake may reduce risk.Objective: We evaluated how intakes of vitamin D and calcium are associated with the incidence of early menopause in the prospective Nurses' Health Study II (NHS2)...
June 2017: American Journal of Clinical Nutrition
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