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H A Fink, S Litwack-Harrison, B C Taylor, D C Bauer, E S Orwoll, C G Lee, E Barrett-Connor, J T Schousboe, D M Kado, P S Garimella, K E Ensrud
No abstract text is available yet for this article.
October 20, 2016: Osteoporosis International
Eric S Orwoll, Jodi Lapidus, Patty Y Wang, Liesbeth Vandenput, Andrew Hoffman, Howard Fink, Gail A Laughlin, Maria Nethander, Östen Ljunggren, Andreas Kindmark, Mattias Lorentzon, Magnus Karlsson, Dan Mellström, Anthony Kwok, Sundeep Khosla, Timothy Kwok, Claes Ohlsson
Measurement of serum testosterone (T) levels is recommended in the evaluation of osteoporosis in older men and estradiol (E2) and sex hormone binding globulin (SHBG) levels are associated with the rate of bone loss and fractures, but the clinical utility of sex steroid and SHBG measurements for the evaluation of osteoporosis in men has not been examined. To evaluate whether measurements of T, E2 and/or SHBG are useful for the prediction of fracture risk or the rate of bone loss in older men, we analyzed longitudinal data from 5487 community-based men participating in the MrOS Study in the US, Sweden and Hong Kong...
October 18, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Kristine E Ensrud, Stephanie L Harrison, Jane A Cauley, Lisa Langsetmo, John T Schousboe, Deborah M Kado, Margaret L Gourlay, Jennifer G Lyons, Lisa Fredman, Nicolas Napoli, Carolyn J Crandall, Cora E Lewis, Eric S Orwoll, Marcia L Stefanick, Peggy M Cawthon
To determine the association of weight loss with risk of clinical fractures at the hip, spine and pelvis (central body fractures [CBF]) in older men with and without accounting for the competing risk of mortality, we used data from 4,523 men (mean age 77.5 years). Weight change between baseline and follow-up (mean 4.5 years between examinations) was categorized as moderate loss (loss ≥10%), mild loss (loss 5% to <10%), stable (<5% change) or gain (gain ≥5%). Participants were contacted every 4 months after the follow-up examination to ascertain vital status (deaths verified by death certificates) and ask about fractures (confirmed by radiographic reports)...
October 14, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Chao Song, Wei Peng, Songna Yin, Jiamin Zhao, Beibei Fu, Jingcheng Zhang, Tingchao Mao, Haibo Wu, Yong Zhang
Increasing evidence shows that melatonin protected against age-related mitochondrial oxidative damage. However, the protective effects of melatonin against ovarian aging has not been explored. Young Kunming females (aged 2-3 months) were fed with melatonin added to drinking water for 6 or 12 months (mo). We found that long-term (12 mo) melatonin treatment significantly reduced ovarian aging, as indicated by substantial increases in litter size, pool of follicles, and telomere length as well as oocyte quantity and quality...
October 12, 2016: Scientific Reports
Wendy B Katzman, Neeta Parimi, Ziba Mansoori, Lorenzo Nardo, Deborah M Kado, Peggy M Cawthon, Lynn M Marshall, John T Schousboe, Nancy E Lane
OBJECTIVE: Investigate cross-sectional and longitudinal associations of Diffuse Idiopathic Skeletal Hyperostosis (DISH) and thoracic kyphosis in older persons. METHODS: DISH and kyphosis were assessed in 1500 men from the Osteoporosis in Men (MrOS) study and 1267 women from the Study of Osteoporotic Fractures (SOF). DISH was assessed in baseline lateral spine radiographs, and Cobb angle of kyphosis was measured from baseline and follow-up radiographs, mean 4.6 years later in men, and 3...
October 9, 2016: Arthritis Care & Research
Shahab Bozorgmehri, Howard A Fink, Neeta Parimi, Benjamin Canales, Kristine E Ensrud, Sonia Ancoli-Israel, Muna Canales
PURPOSE: To investigate the association between sleep-disordered breathing (SDB) and erectile dysfunction (ED) in older men. METHODS: We performed a cross-sectional analysis of community-dwelling men aged ≥67 years enrolled in the MrOS Sleep Study. Participants underwent overnight polysomnography (2003-2005) and completed sexual health questionnaires (2005-2006). We defined SDB using the apnea-hypopnea-index (AHI) or nocturnal hypoxemia. ED was defined using the Massachusetts Male Aging Study (MMAS) scale and, in sexually active men, the International Index of Erectile Function (IIEF-5)...
September 30, 2016: Journal of Urology
Elizabeth E Devore, Stephanie L Harrison, Katie L Stone, Kathleen F Holton, Elizabeth Barrett-Connor, Sonia Ancoli-Israel, Kristine Yaffe, Kristine Ensrud, Peggy M Cawthon, Susan Redline, Eric Orwoll, Eva S Schernhammer
BACKGROUND: Circadian disruptions can contribute to accelerated aging, and the circadian system regulates cognitive and physical functions; therefore, circadian markers (eg, melatonin) may be associated with key aspects of healthy aging and longevity. OBJECTIVE: To evaluate urinary melatonin levels in relation to cognitive function, physical function, and mortality among 2,821 older men in the Osteoporotic Fractures in Men Study DESIGN: Cohort study. MEASUREMENTS: In 2003-2005, participants provided first-morning spot urine samples, which were assayed for 6-sulfatoxymelatonin (the primary melatonin metabolite in urine); cognitive and physical function assessments were completed twice, at baseline and an average of 6...
July 2016: Sleep Medicine
Ryan M R Gawryluk, Ryoma Kamikawa, Courtney W Stairs, Jeffrey D Silberman, Matthew W Brown, Andrew J Roger
Mitochondria exist on a functional and evolutionary continuum that includes anaerobic mitochondrion-related organelles (MROs), such as hydrogenosomes. Hydrogenosomes lack many classical mitochondrial features, including conspicuous cristae, mtDNA, the tricarboxylic acid (TCA) cycle, and ATP synthesis powered by an electron transport chain (ETC); instead, they produce ATP anaerobically, liberating H2 and CO2 gas in the process. However, our understanding of the evolutionary transformation from aerobic mitochondria to various MRO types remains incomplete...
September 13, 2016: Current Biology: CB
Timothy Kwok, Jason Leung, Elizabeth Barrett-Connor
INTRODUCTION: angiotensin II, a major effector protein of the renin angiotensin system (RAS), induces bone loss under certain conditions. Drugs that block the RAS may therefore reduce bone loss and fracture incidence. The fracture incidence in older hypertensive men with long-term use of angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) were compared with the incidence in users of calcium channel blockers (CCBs) and non-users. METHODS: a total of 5,994 US men aged 65 years or older who had bone mineral density measured at baseline in the Osteoporotic Fractures in Men Study (MrOS) were followed for fracture incidence for an average of 6...
September 10, 2016: Age and Ageing
Mehrsa Kherad, Björn E Rosengren, Ralph Hasserius, Jan-Åke Nilsson, Inga Redlund-Johnell, Claes Ohlsson, Dan Mellström, Mattiaz Lorentzon, Östen Ljunggren, Magnus K Karlsson
INTRODUCTION: the aim of this study was to identify whether factors beyond anatomical abnormalities are associated with low back pain (LBP) and LBP with sciatica (SCI) in older men. MATERIAL AND METHODS: Mister Osteoporosis Sweden includes 3,014 men aged 69-81 years. They answered questionnaires on lifestyle and whether they had experienced LBP and SCI during the preceding 12 months. About 3,007 men answered the back pain (BP) questions, 258 reported BP without specified region...
September 8, 2016: Age and Ageing
Ran-Ran Chai, Guo-Wu Chen, Hui-Juan Shi, Wai-Sum O, Patricia A Martin-DeLeon, Hong Chen
Prohibitin (PHB), a major mitochondrial membrane protein, has been shown earlier in our laboratoryto regulate sperm motility via an alteration in mitochondrial membrane potential (MMP) in infertile men with poor sperm quality. To test if PHB expression is associated with sperm mitochondrial superoxide (mROS) levels, here we examined sperm mROS levels, high MMP and lipid peroxidation in infertile men with poor sperm motility (asthenospermia, A) and/or low sperm concentrations (oligoasthenospermia, OA). The diaphorase-type activity of sperm mitochondrial complex I (MCI) and PHB expression were also determined...
August 25, 2016: Journal of Cellular and Molecular Medicine
Didier Chalhoub, Eric S Orwoll, Peggy M Cawthon, Kristine E Ensrud, Robert Boudreau, Susan Greenspan, Anne B Newman, Joseph Zmuda, Douglas Bauer, Steven Cummings, Jane A Cauley
Although many studies have examined the association between low bone mineral density (BMD) and fracture risk in older men, none have simultaneously studied the relationship between multiple BMD sites and risk of different types of fractures. Using data from the Osteoporotic Fractures in Men study, we evaluated the association between areal BMD (aBMD) by dual-energy X-ray absorptiometry (DXA) and volumetric BMD (vBMD) by quantitative computed tomography (QCT) measurements, and different types of fractures during an average of 9...
November 2016: Bone
Brian B Koo, Terri Blackwell, Hochang B Lee, Katie L Stone, Elan D Louis, Susan Redline
OBJECTIVE: To investigate an association between restless legs syndrome (RLS) and depression and to what extent sleep disturbance, periodic limb movements during sleep (PLMS), and antidepressant medication mediate this relationship. METHODS: A cross-sectional analysis was conducted of the Osteoporotic Fractures in Older Men Study data in 982 men assessed for RLS (International RLS Study Group scale [IRLSS]) and depression (Geriatric Depression Scale [GDS]), who underwent actigraphy (for sleep latency/efficiency) and polysomnography (for PLMS)...
November 2016: American Journal of Geriatric Psychiatry
Yi Wen, Yiran Liu, Taotao Tang, Linli Lv, Hong Liu, Kunling Ma, Bicheng Liu
Growing evidence has shown that NLRP3 inflammasome activation promotes the development of tubularinterstitial inflammation and progression of renal injury. We previously found that mitochondrial dysfunction is a critical determinant for the activation of NLRP3 inflammasome in albumin-overload rats. Angiotensin (Ang) II plays an important role in mitochondrial homeostasis. Here, we investigated the role of Ang II in NLRP3 inflammasome activation and the involvement of mitochondrial dysfunction in this process...
August 5, 2016: Oncotarget
Mary H Samuels, Rajani Kaimal, Avantika Waring, Howard A Fink, Kristine Yaffe, Andrew R Hoffman, Eric Orwoll, Douglas Bauer
BACKGROUND: Variations in thyroid function within the laboratory reference range have been associated with a number of clinical outcomes. However, quality of life, mood, and cognitive function have not been extensively studied, and it is not clear whether mild variations in thyroid function have major effects on these neurocognitive outcomes. METHODS: Data were analyzed from the Osteoporotic Fractures in Men (MrOS) Study, a cohort of community-dwelling men aged 65 years and older in the United States...
September 2016: Thyroid: Official Journal of the American Thyroid Association
Elizabeth R Hooker, Smriti Shrestha, Christine G Lee, Peggy M Cawthon, Melanie Abrahamson, Kris Ensrud, Marcia L Stefanick, Thuy-Tien Dam, Lynn M Marshall, Eric S Orwoll, Carrie M Nielson
OBJECTIVE: The aim of this study is to evaluate fall rates across body mass index (BMI) categories by age group, considering physical performance and comorbidities. METHOD: In the Osteoporotic Fractures in Men (MrOS) study, 5,834 men aged ≥65 reported falls every 4 months over 4.8 (±0.8) years. Adjusted associations between BMI and an incident fall were tested using mixed-effects models. RESULTS: The fall rate (0.66/man-year overall, 95% confidence interval [CI] = [0...
July 27, 2016: Journal of Aging and Health
Nicola Napoli, Anne L Schafer, Li-Yung Lui, Jane A Cauley, Elsa S Strotmeyer, Erin S Le Blanc, Andrew R Hoffman, Christine G Lee, Dennis M Black, Ann V Schwartz
The association between vitamin D status and diabetes risk is inconsistent among observational studies, and most of the available studies have been with women. In the present study we investigated the association between serum 25-hydroxyvitamin D (25(OH)D) levels and incident type 2 diabetes (T2D) in older men (≥65years old) who participated in the multisite Osteoporotic Fractures in Men (MrOS) study enrolled from March 2000 to April 2002. Baseline 25(OH)D levels were available in 1939 subjects without prevalent T2D...
September 2016: Bone
Karine Briot, Jacques Fechtenbaum, Christian Roux
No abstract text is available yet for this article.
August 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Jane A Cauley, Kamil E Barbour, Stephanie L Harrison, Yona K Cloonan, Michelle E Danielson, Kristine E Ensrud, Howard A Fink, Eric S Orwoll, Robert Boudreau
Cytokines play major roles in regulating bone remodeling but their relationship to incident fractures in older men is uncertain. We tested the hypothesis that men with higher concentrations of pro-inflammatory markers have a higher risk of fracture. We used a case-cohort design and measured inflammatory markers in a random sample of 961 men and in men with incident fractures including 120 clinical vertebral, 117 hip and 577 non-spine fractures; average follow up, 6.13 years (7.88 years for vertebral fractures)...
July 2, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Gina N Woods, Mei-Hua Huang, Peggy M Cawthon, Gail A Laughlin, John T Schousboe, Corinne McDaniels-Davidson, Jane A Cauley, Eric Orwoll, Elizabeth Barrett-Connor, Deborah M Kado
Accentuated kyphosis is associated with adverse health outcomes including falls and fractures. Low bone density is a risk factor for hyperkyphosis, and each vertebral fracture adds roughly 4 degrees to forward spine curvature. Sex steroids, in particular low bioavailable estradiol and high SHBG, are associated with bone loss and high SHBG is associated with vertebral fractures in older men. We therefore hypothesized that low bioavailable estradiol and high SHBG would be associated with worse kyphosis. To test this hypothesis, we examined the cross-sectional associations between individual bioavailable sex hormones and SHBG with radiographically assessed kyphosis...
June 29, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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