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https://www.readbyqxmd.com/read/28063379/oxidative-stress-mitochondrial-abnormalities-and-antioxidant-defense-in-ataxia-telangiectasia-bloom-syndrome-and-nijmegen-breakage-syndrome
#1
REVIEW
Mateusz Maciejczyk, Bozena Mikoluc, Barbara Pietrucha, Edyta Heropolitanska-Pliszka, Malgorzata Pac, Radosław Motkowski, Halina Car
Rare pleiotropic genetic disorders, Ataxia-telangiectasia (A-T), Bloom syndrome (BS) and Nijmegen breakage syndrome (NBS) are characterised by immunodeficiency, extreme radiosensitivity, higher cancer susceptibility, premature aging, neurodegeneration and insulin resistance. Some of these functional abnormalities can be explained by aberrant DNA damage response and chromosomal instability. It has been suggested that one possible common denominator of these conditions could be chronic oxidative stress caused by endogenous ROS overproduction and impairment of mitochondrial homeostasis...
December 28, 2016: Redox Biology
https://www.readbyqxmd.com/read/28035213/peroxiredoxin-3-is-involved-in-bactericidal-activity-through-the-regulation-of-mitochondrial-reactive-oxygen-species
#2
Sena Lee, Sae Mi Wi, Yoon Min, Ki-Young Lee
Peroxiredoxin-3 (Prdx3) is a mitochondrial protein of the thioredoxin family of antioxidant peroxidases and is the principal peroxidase responsible for metabolizing mitochondrial hydrogen peroxide. Recent reports have shown that mitochondrial reactive oxygen species (mROS) contribute to macrophage-mediated bactericidal activity in response to Toll-like receptors. Herein, we investigated the functional effect of Prdx3 in bactericidal activity. The mitochondrial localization of Prdx3 in HEK293T cells was confirmed by cell fractionation and confocal microscopy analyses...
December 2016: Immune Network
https://www.readbyqxmd.com/read/28013364/rest-activity-patterns-and-falls-and-fractures-in-older-men
#3
Tara S Rogers, Terri L Blackwell, Nancy E Lane, Greg Tranah, Eric S Orwoll, Jane A Cauley, Sonia Ancoli-Israel, Katie L Stone, Steven R Cummings, Peggy M Cawthon
: Dysregulated rest-activity rhythm (RAR) patterns have been associated with several health conditions in older adults. This study showed that later acrophase was associated with a modestly greater risk of falls but not fractures in elderly men. Associations between dysregulated RAR patterns and osteoporosis risk warrant further investigation. PURPOSE: The purpose of this study was to investigate the relationship between rest-activity rhythm (RAR) patterns and risk of falls/fractures in older men...
December 24, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/28012217/association-of-increased-urinary-albumin-with-risk-of-incident-clinical-fracture-and-rate-of-hip-bone-loss-the-osteoporotic-fractures-in-men-study
#4
Howard A Fink, Tien N Vo, Lisa Langsetmo, Joshua I Barzilay, Jane A Cauley, John T Schousboe, Eric S Orwoll, Muna T Canales, Areef Ishani, Nancy E Lane, Kristine E Ensrud
Prior studies suggest that increased urine albumin is associated with a heightened fracture risk in women, but results in men are unclear. We used data from MrOS, a prospective cohort study of community-dwelling men aged ≥65 years, to evaluate the association of increased urine albumin with subsequent fractures and annualized rate of hip bone loss. We calculated albumin/creatinine ratio (ACR) from urine collected at the 2003-05 visit. Subsequent clinical fractures were ascertained from triannual questionnaires and centrally adjudicated by review of radiographic reports...
December 24, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28001907/ionizing-radiation-induces-innate-immune-responses-in-macrophages-by-generation-of-mitochondrial-reactive-oxygen-species
#5
Sup Kim, Jin Ho Choe, Gippeum Joy Lee, Yi Sak Kim, Soo Yeon Kim, Hye-Mi Lee, Hyo Sun Jin, Tae Sung Kim, Jin-Man Kim, Moon-June Cho, Eui-Cheol Shin, Eun-Kyeong Jo, Jun-Sang Kim
During radiotherapy for tumors, the innate immune system also responds to ionizing radiation and induces immune modulation. However, little is known about the molecular mechanisms by which radiation modulates innate immune responses. In this study, we observed that radiation triggered the generation of mitochondrial reactive oxygen species (mROS), leading to innate immune responses in murine bone marrow-derived macrophages (BMDM). Radiation-induced mROS was essential for robust induction of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and IL-12p40 mRNA and protein in BMDM...
December 21, 2016: Radiation Research
https://www.readbyqxmd.com/read/27943394/the-association-between-protein-intake-by-source-and-osteoporotic-fracture-in-older-men-a-prospective-cohort-study
#6
Lisa Langsetmo, James M Shikany, Peggy M Cawthon, Jane A Cauley, Brent C Taylor, Tien N Vo, Douglas C Bauer, Eric S Orwoll, John T Schousboe, Kristine E Ensrud
Dietary protein is a potentially modifiable risk factor for fracture. Our objectives were to assess the association of protein intake with incident fracture among older men and whether these associations varied by protein source or by skeletal site. We studied a longitudinal cohort of 5875 men (mean age 73.6, SD = 5.9 years) in the Osteoporotic Fractures in Men (MrOS) study. At baseline, protein intake was assessed as percent of total energy intake (TEI) with mean intake from all sources = 16.1%TEI...
December 12, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27938334/prevalent-peripheral-arterial-disease-and-inflammatory-burden
#7
Jane A Cauley, Ahmed M Kassem, Nancy E Lane, Sara Thorson
BACKGROUND: Strong evidence implicates inflammation in the development of atherosclerotic heart disease but less is known about peripheral arterial disease (PAD). Our objective was to test the hypothesis that a composite index of inflammatory burden is associated with PAD. METHODS: Cross-sectional analysis of a randomly-selected group of 903 community-dwelling men in the MrOS cohort recruited between 2000 and 2002. Using blood samples, we measured seven cytokines and related these levels to prevalent PAD (ankle-brachial index (ABI) <0...
December 9, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27930804/increased-mitochondrial-ros-generation-mediates-the-loss-of-pvat-anticontractile-effect-in-hfd-treated-obese-mice
#8
Rafael Menezes da Costa, Rafael S Fais, Carlos R P Dechandt, Paulo Louzada-Junior, Luciane C Alberici, Núbia S Lobato, Rita C Tostes
Obesity is associated with structural and functional changes in the perivascular adipose tissue (PVAT), favoring the release of reactive oxygen species (ROS), vasoconstrictor and proinflammatory factors. Tumor necrosis factor alpha (TNF-α) induces vascular dysfunction and is produced by the PVAT. We tested the hypothesis that obesity-associated PVAT dysfunction is mediated by augmented mitochondrial ROS (mROS) generation due to increased TNF-α production in this tissue. Aortae from high fat diet (HFD)-fed obese mice displayed increased contractions to phenylephrine (PE) and loss of PVAT anticontractile effect...
December 8, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27889439/when-a-gold-standard-isn-t-so-golden-lack-of-prediction-of-subjective-sleep-quality-from-sleep-polysomnography
#9
Katherine A Kaplan, Jason Hirshman, Beatriz Hernandez, Marcia L Stefanick, Andrew R Hoffman, Susan Redline, Sonia Ancoli-Israel, Katie Stone, Leah Friedman, Jamie M Zeitzer
BACKGROUND: Reports of subjective sleep quality are frequently collected in research and clinical practice. It is unclear, however, how well polysomnographic measures of sleep correlate with subjective reports of prior-night sleep quality in elderly men and women. Furthermore, the relative importance of various polysomnographic, demographic and clinical characteristics in predicting subjective sleep quality is not known. We sought to determine the correlates of subjective sleep quality in older adults using more recently developed machine learning algorithms that are suitable for selecting and ranking important variables...
November 24, 2016: Biological Psychology
https://www.readbyqxmd.com/read/27852636/a-prospective-study-of-back-pain-and-risk-of-falls-among-older-community-dwelling-men
#10
Lynn M Marshall, Stephanie Litwack-Harrison, Una E Makris, Deborah M Kado, Peggy M Cawthon, Richard A Deyo, Nels L Carlson, Michael C Nevitt
BACKGROUND: Musculoskeletal pain is associated with increased fall risk among older men. However, the association of back pain, the most prevalent type of pain in this population, and fall risk is unknown. METHODS: We conducted a prospective investigation among 5,568 community-dwelling U.S. men at least 65 years of age from the Osteoporotic Fractures in Men Study (MrOS). Baseline questionnaires inquired about back pain and its location (such as low back), severity, and frequency in the past year...
November 16, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27823721/longitudinal-relationships-of-periodic-limb-movements-during-sleep-and-incident-atrial-fibrillation
#11
Anna M May, Terri Blackwell, Katie L Stone, Peggy M Cawthon, William H Sauer, Paul D Varosy, Susan Redline, Brian B Koo, Reena Mehra
OBJECTIVES: This study aimed to examine relationship between periodic limb movements during sleep (PLMS) and incident atrial fibrillation/flutter (AF). METHODS: Prospective multicenter cohort (n = 2273: adjudicated AF group; n = 843: self-reported AF group) of community-dwelling men without prevalent AF were followed for an average of 8.3 years (adjudicated) and 6.5 years (self-reported). PLMS index (PLMI, <5 (ref), ≥5 to <30, ≥30) and PLM arousal index (PLMAI, <1 (ref), ≥1 to <5, ≥5) were measured by polysomnography...
September 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27766366/erratum-to-clinical-utility-of-routine-laboratory-testing-to-identify-possible-secondary-causes-in-older-men-with-osteoporosis-the-osteoporotic-fractures-in-men-mros-study
#12
H A Fink, S Litwack-Harrison, B C Taylor, D C Bauer, E S Orwoll, C G Lee, E Barrett-Connor, J T Schousboe, D M Kado, P S Garimella, K E Ensrud
No abstract text is available yet for this article.
January 2017: Osteoporosis International
https://www.readbyqxmd.com/read/27753150/the-limited-clinical-utility-of-testosterone-estradiol-and-sex-hormone-binding-globulin-measurements-in-the-prediction-of-fracture-risk-and-bone-loss-in-older-men
#13
Eric S Orwoll, Jodi Lapidus, Patty Y Wang, Liesbeth Vandenput, Andrew Hoffman, Howard A Fink, Gail A Laughlin, Maria Nethander, Östen Ljunggren, Andreas Kindmark, Mattias Lorentzon, Magnus K Karlsson, Dan Mellström, Anthony Kwok, Sundeep Khosla, Timothy Kwok, Claes Ohlsson
Measurement of serum testosterone (T) levels is recommended in the evaluation of osteoporosis in older men and estradiol (E2) and sex hormone binding globulin (SHBG) levels are associated with the rate of bone loss and fractures, but the clinical utility of sex steroid and SHBG measurements for the evaluation of osteoporosis in men has not been examined. To evaluate whether measurements of T, E2, and/or SHBG are useful for the prediction of fracture risk or the rate of bone loss in older men, we analyzed longitudinal data from 5487 community-based men participating in the Osteoporotic Fractures in Men (MrOS) study in the United States, Sweden, and Hong Kong...
October 18, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27739103/impact-of-competing-risk-of-mortality-on-association-of-weight-loss-with-risk-of-central-body-fractures-in-older-men-a-prospective-cohort-study
#14
Kristine E Ensrud, Stephanie L Harrison, Jane A Cauley, Lisa Langsetmo, John T Schousboe, Deborah M Kado, Margaret L Gourlay, Jennifer G Lyons, Lisa Fredman, Nicolas Napoli, Carolyn J Crandall, Cora E Lewis, Eric S Orwoll, Marcia L Stefanick, Peggy M Cawthon
To determine the association of weight loss with risk of clinical fractures at the hip, spine and pelvis (central body fractures [CBF]) in older men with and without accounting for the competing risk of mortality, we used data from 4,523 men (mean age 77.5 years). Weight change between baseline and follow-up (mean 4.5 years between examinations) was categorized as moderate loss (loss ≥10%), mild loss (loss 5% to <10%), stable (<5% change) or gain (gain ≥5%). Participants were contacted every 4 months after the follow-up examination to ascertain vital status (deaths verified by death certificates) and ask about fractures (confirmed by radiographic reports)...
October 14, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27731402/melatonin-improves-age-induced-fertility-decline-and-attenuates-ovarian-mitochondrial-oxidative-stress-in-mice
#15
Chao Song, Wei Peng, Songna Yin, Jiamin Zhao, Beibei Fu, Jingcheng Zhang, Tingchao Mao, Haibo Wu, Yong Zhang
Increasing evidence shows that melatonin protected against age-related mitochondrial oxidative damage. However, the protective effects of melatonin against ovarian aging has not been explored. Young Kunming females (aged 2-3 months) were fed with melatonin added to drinking water for 6 or 12 months (mo). We found that long-term (12 mo) melatonin treatment significantly reduced ovarian aging, as indicated by substantial increases in litter size, pool of follicles, and telomere length as well as oocyte quantity and quality...
October 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27723250/cross-sectional-and-longitudinal-associations-of-diffuse-idiopathic-skeletal-hyperostosis-dish-and-thoracic-kyphosis-in-older-men-and-women
#16
Wendy B Katzman, Neeta Parimi, Ziba Mansoori, Lorenzo Nardo, Deborah M Kado, Peggy M Cawthon, Lynn M Marshall, John T Schousboe, Nancy E Lane
OBJECTIVE: Investigate cross-sectional and longitudinal associations of Diffuse Idiopathic Skeletal Hyperostosis (DISH) and thoracic kyphosis in older persons. METHODS: DISH and kyphosis were assessed in 1500 men from the Osteoporosis in Men (MrOS) study and 1267 women from the Study of Osteoporotic Fractures (SOF). DISH was assessed in baseline lateral spine radiographs, and Cobb angle of kyphosis was measured from baseline and follow-up radiographs, mean 4.6 years later in men, and 3...
October 9, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27697577/association-of-sleep-disordered-breathing-with-erectile-dysfunction-in-community-dwelling-older-men
#17
Shahab Bozorgmehri, Howard A Fink, Neeta Parimi, Benjamin Canales, Kristine E Ensrud, Sonia Ancoli-Israel, Muna Canales
PURPOSE: We investigated the association between sleep disordered breathing and erectile dysfunction in older men. MATERIALS AND METHODS: We performed a cross-sectional analysis of community dwelling men age 67 years or older enrolled in the Osteoporotic Fractures in Men Sleep Study. Participants underwent overnight polysomnography (2003 to 2005) and completed sexual health questionnaires (2005 to 2006). We defined sleep disordered breathing using the apnea-hypopnea index or nocturnal hypoxemia...
September 30, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27692280/association-of-urinary-melatonin-levels-and-aging-related-outcomes-in-older-men
#18
Elizabeth E Devore, Stephanie L Harrison, Katie L Stone, Kathleen F Holton, Elizabeth Barrett-Connor, Sonia Ancoli-Israel, Kristine Yaffe, Kristine Ensrud, Peggy M Cawthon, Susan Redline, Eric Orwoll, Eva S Schernhammer
BACKGROUND: Circadian disruptions can contribute to accelerated aging, and the circadian system regulates cognitive and physical functions; therefore, circadian markers (eg, melatonin) may be associated with key aspects of healthy aging and longevity. OBJECTIVE: To evaluate urinary melatonin levels in relation to cognitive function, physical function, and mortality among 2,821 older men in the Osteoporotic Fractures in Men Study DESIGN: Cohort study. MEASUREMENTS: In 2003-2005, participants provided first-morning spot urine samples, which were assayed for 6-sulfatoxymelatonin (the primary melatonin metabolite in urine); cognitive and physical function assessments were completed twice, at baseline and an average of 6...
July 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27666965/the-earliest-stages-of-mitochondrial-adaptation-to-low-oxygen-revealed-in-a-novel-rhizarian
#19
Ryan M R Gawryluk, Ryoma Kamikawa, Courtney W Stairs, Jeffrey D Silberman, Matthew W Brown, Andrew J Roger
Mitochondria exist on a functional and evolutionary continuum that includes anaerobic mitochondrion-related organelles (MROs), such as hydrogenosomes. Hydrogenosomes lack many classical mitochondrial features, including conspicuous cristae, mtDNA, the tricarboxylic acid (TCA) cycle, and ATP synthesis powered by an electron transport chain (ETC); instead, they produce ATP anaerobically, liberating H2 and CO2 gas in the process. However, our understanding of the evolutionary transformation from aerobic mitochondria to various MRO types remains incomplete...
September 13, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27614079/arb-users-exhibit-a-lower-fracture-incidence-than-ace-inhibitor-users-among-older-hypertensive-men
#20
Timothy Kwok, Jason Leung, Elizabeth Barrett-Connor
INTRODUCTION: angiotensin II, a major effector protein of the renin angiotensin system (RAS), induces bone loss under certain conditions. Drugs that block the RAS may therefore reduce bone loss and fracture incidence. The fracture incidence in older hypertensive men with long-term use of angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) were compared with the incidence in users of calcium channel blockers (CCBs) and non-users. METHODS: a total of 5,994 US men aged 65 years or older who had bone mineral density measured at baseline in the Osteoporotic Fractures in Men Study (MrOS) were followed for fracture incidence for an average of 6...
September 10, 2016: Age and Ageing
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