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https://www.readbyqxmd.com/read/29124252/bone-loss-at-the-hip-and-subsequent-mortality-in-older-men-the-osteoporotic-fractures-in-men-mros-study
#1
Peggy M Cawthon, Sheena Patel, Susan K Ewing, Li-Yung Lui, Jane A Cauley, Jennifer G Lyons, Lisa Fredman, Deborah M Kado, Andrew R Hoffman, Nancy E Lane, Kristine E Ensrud, Steven R Cummings, Eric S Orwoll
Low bone mineral density (BMD) is associated with increased mortality risk, yet the impact of BMD loss on mortality is relatively unknown. We hypothesized that greater BMD loss is associated with increased mortality risk in older men. Change in femoral neck BMD was assessed in 4400 Osteoporotic Fractures in Men (MrOS) study participants with two to three repeat dual-energy X-ray absorptiometry scans over an average of 4.6 ± 0.4 (mean ± SD) years. Change in femoral neck BMD was estimated using mixed effects models; men were grouped into three categories of BMD change: maintenance (n = 1087; change ≥ 0 g/cm(2)); expected loss (n = 2768; change between 0 g/cm(2) and <1 SD below mean change [>-0...
August 2017: JBMR Plus
https://www.readbyqxmd.com/read/29116457/correction-to-comparison-of-fracture-risk-assessment-tools-in-older-men-without-prior-hip-or-spine-fracture-the-mros-study
#2
Margaret L Gourlay, Victor S Ritter, Jason P Fine, Robert A Overman, John T Schousboe, Peggy M Cawthon, Eric S Orwoll, Tuan V Nguyen, Nancy E Lane, Steven R Cummings, Deborah M Kado, Jodi A Lapidus, Susan J Diem, Kristine E Ensrud
Owing to an oversight by the authors, the acknowledgments were incomplete.
November 7, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29090329/predictors-of-change-of-trabecular-bone-score-tbs-in-older-men-results-from-the-osteoporotic-fractures-in-men-mros-study
#3
J T Schousboe, T N Vo, L Langsetmo, B C Taylor, A M Kats, A V Schwartz, D C Bauer, J A Cauley, K E Ensrud
Among older men, characteristics that predict longitudinal changes in trabecular bone score (TBS) are different from characteristics that predict changes in bone mineral density (BMD). Most notably, weight loss is strongly associated with concomitant loss in BMD but with concomitant increases in TBS, when measured on Hologic densitometers. INTRODUCTION: Our objective was to compare and contrast predictors of changes in TBS, total hip BMD, and lumbar spine BMD. METHODS: Our study population was 3969 Osteoporotic Fractures in Men (MrOS) cohort participants (mean age 72...
October 31, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29063213/high-dairy-protein-intake-is-associated-with-greater-bone-strength-parameters-at-the-distal-radius-and-tibia-in-older-men-a-cross-sectional-study
#4
L Langsetmo, J M Shikany, A J Burghardt, P M Cawthon, E S Orwoll, J A Cauley, B C Taylor, J T Schousboe, D C Bauer, T N Vo, K E Ensrud
Dairy protein but not plant protein was associated with bone strength of the radius and tibia in older men. These results are consistent with previous results in women and support similar findings related to fracture outcomes. Bone strength differences were largely due to thickness and area of the bone cortex. INTRODUCTION: Our objective was to determine the association of protein intake by source (dairy, non-dairy animal, plant) with bone strength and bone microarchitecture among older men...
October 23, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29052793/comparison-of-fracture-risk-assessment-tools-in-older-men-without-prior-hip-or-spine-fracture-the-mros-study
#5
Margaret L Gourlay, Victor S Ritter, Jason P Fine, Robert A Overman, John T Schousboe, Peggy M Cawthon, Eric S Orwoll, Tuan V Nguyen, Nancy E Lane, Steven R Cummings, Deborah M Kado, Jodi A Lapidus, Susan J Diem, Kristine E Ensrud
Femoral neck bone mineral density (BMD), age plus femoral neck BMD T score, and three externally generated fracture risk tools had similar accuracy to identify older men who developed osteoporotic fractures. Risk tools with femoral neck BMD performed better than those without BMD. The externally developed risk tools were poorly calibrated. INTRODUCTION: We compared the performance of fracture risk assessment tools in older men, accounting for competing risks including mortality. METHODS: A comparative ROC curve analysis assessed the ability of the QFracture, FRAX® and Garvan fracture risk tools, and femoral neck bone mineral density (BMD) T score with or without age to identify incident fracture in community-dwelling men aged 65 years or older (N = 4994) without hip or clinical vertebral fracture or antifracture treatment at baseline...
October 20, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29044162/hetero-oligomer-of-dynamin-related-proteins-participates-in-the-fission-of-highly-divergent-mitochondria-from-entamoeba-histolytica
#6
Takashi Makiuchi, Herbert J Santos, Hiroshi Tachibana, Tomoyoshi Nozaki
Entamoeba histolytica is an anaerobic parasitic protist and possesses mitosomes, one of the most highly divergent mitochondrion-related organelles (MROs). Although unique metabolism and protein/metabolite transport machinery have been demonstrated in Entamoeba mitosomes, the mechanism of mitosomal fusion and fission remains to be elucidated. In this study, we demonstrate that two dynamin-related proteins (DRPs) are cooperatively involved in the fission of Entamoeba mitosomes. Expression of a dominant negative form of EhDrpA and EhDrpB, and alternatively, repression of gene expression of EhDrpA and EhDrpB genes, caused elongation of mitosomes, reflecting inhibition of mitosomal fission...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29029009/the-effect-of-physical-activity-and-cardiorespiratory-fitness-on-all-cause-mortality-in-hong-kong-chinese-older-people
#7
Zhihui Lu, Jean Woo, Timothy Kwok
Background: It is unclear whether physical activity (PA) could predict all-cause mortality independently of cardiorespiratory fitness, and there are relatively few studies evaluating the combined effect of PA and cardiorespiratory fitness on mortality. Methods: We invited 1,242 Chinese older adults aged 69 to 94 years from the MrOs and MsOs cohort (Hong Kong) study for a 7-year follow-up. PA was measured by the Physical Activity Scale of the Elderly (PASE). Cardiorespiratory fitness, expressed as maximal oxygen uptake (VO2max), was assessed by performing symptom-limited maximal exercise testing on an electrically braked bicycle ergometer and 6-meter walk test...
September 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29024797/nlrx1-modulates-differentially-nlrp3-inflammasome-activation-and-nf-%C3%AE%C2%BAb-signaling-during-fusobacterium-nucleatum-infection
#8
Shu-Chen Hung, Pei-Rong Huang, Cássio Luiz Coutinho Almeida-da-Silva, Kalina R Atanasova, Ozlem Yilmaz, David M Ojcius
NOD-like receptors (NLRs) play a large role in regulation of host innate immunity, yet their role in periodontitis remains to be defined. NLRX1, a member of the NLR family that localizes to mitochondria, enhances mitochondrial ROS (mROS) generation. mROS can activate the NLRP3 inflammasome, yet the role of NLRX1 in NLRP3 inflammasome activation has not been examined. In this study, we revealed the mechanism by which NLRX1 positively regulates ATP-induced NLRP3 inflammasome activation through mROS in gingival epithelial cells (GECs)...
October 9, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28978464/ampk-maintains-cellular-metabolic-homeostasis-through-regulation-of-mitochondrial-reactive-oxygen-species
#9
Rebecca C Rabinovitch, Bozena Samborska, Brandon Faubert, Eric H Ma, Simon-Pierre Gravel, Sylvia Andrzejewski, Thomas C Raissi, Arnim Pause, Julie St-Pierre, Russell G Jones
Reactive oxygen species (ROS) are continuously produced as a by-product of mitochondrial metabolism and eliminated via antioxidant systems. Regulation of mitochondrially produced ROS is required for proper cellular function, adaptation to metabolic stress, and bypassing cellular senescence. Here, we report non-canonical regulation of the cellular energy sensor AMP-activated protein kinase (AMPK) by mitochondrial ROS (mROS) that functions to maintain cellular metabolic homeostasis. We demonstrate that mitochondrial ROS are a physiological activator of AMPK and that AMPK activation triggers a PGC-1α-dependent antioxidant response that limits mitochondrial ROS production...
October 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/28942368/dxa-derived-hip-shape-is-related-to-osteoarthritis-findings-from-in-the-mros-cohort
#10
B G Faber, D Baird, C L Gregson, J S Gregory, R J Barr, R M Aspden, J Lynch, M C Nevitt, N E Lane, E Orwoll, J H Tobias
OBJECTIVE: Statistical shape modelling (SSM) of radiographs has been used to explore relationships between altered joint shape and hip osteoarthritis (OA). We aimed to apply SSM to Dual-energy X-ray Absorptiometry (DXA) hip scans, and examine associations between resultant hip shape modes (HSMs), radiographic hip OA (RHOA), and hip pain, in a large population based cohort. METHOD: SSM was performed on baseline hip DXA scans from the Osteoporotic Fractures in Men (MrOS) Study...
September 21, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28934150/frailty-and-its-contributory-factors-in-older-adults-a-comparison-of-two-asian-regions-hong-kong-and-taiwan
#11
Ruby Yu, Wan-Chi Wu, Jason Leung, Susan C Hu, Jean Woo
This study aimed to compare the prevalence of frailty across three Chinese populations: Hong Kong, Taiwan-urban and Taiwan-rural. Contributing factors to disparities in frailty were also examined. Data were derived from the Osteoporotic Fractures in Men (MrOs) and Women (MsOs) (Hong Kong) Study (n = 4000) and the Taiwan Longitudinal Study on Aging (n = 2392). Frailty was defined as an index calculated from 30 multiple deficits. The ratio of the frailty index to life expectancy at birth (FI/LE) was used as an indicator of compression of morbidity...
September 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28880398/association-of-incident-clinically-undiagnosed-radiographic-vertebral-fractures-with-follow-up-back-pain-symptoms-in-older-men-the-osteoporotic-fractures-in-men-mros-study
#12
Howard A Fink, Stephanie Litwack-Harrison, Kristine E Ensrud, Jian Shen, John T Schousboe, Peggy M Cawthon, Jane A Cauley, Nancy E Lane, Brent C Taylor, Elizabeth Barrett-Connor, Deborah M Kado, Steven R Cummings, Lynn M Marshall
Prior data in women suggest that incident clinically undiagnosed radiographic vertebral fractures (VFs) often are symptomatic, but misclassification of incident clinical VF may have biased these estimates. There are no comparable data in men. To evaluate the association of incident clinically undiagnosed radiographic VF with back pain symptoms and associated activity limitations, we used data from the Osteoporotic Fractures in Men (MrOS) Study, a prospective cohort study of community-dwelling men aged ≥65 years...
November 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28861910/vertebral-fracture-risk-in-diabetic-elderly-men-the-mros-study
#13
Nicola Napoli, Ann V Schwartz, Anne L Schafer, Eric Vittinghoff, Peggy Cawthon, Neeta Parimi, Eric Orwoll, Elsa S Strotmeyer, Andrew R Hoffman, Elizabeth Barrett-Connor, Dennis M Black
Type 2 diabetes (T2DM) is associated with a significant increase in risk of non-vertebral fractures, but information on the vertebral fracture (VFs) risk in subjects with T2DM, particularly among men, is lacking. Furthermore, it is not known whether spine bone mineral density (BMD) can predict the risk of vertebral-fracture in T2DM. We sought to examine the effect of diabetes status on prevalent and incident vertebral fracture, and to estimate the effect of lumbar spine BMD (areal and volumetric) as a risk factor for prevalent and incident morphometric vertebral fracture in T2DM (n = 875) and non-diabetic men (n = 4679)...
September 1, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28758328/the-path-from-mitochondrial-ros-to-aging-runs-through-the-mitochondrial-permeability-transition-pore
#14
REVIEW
Hagai Rottenberg, Jan B Hoek
Excessive production of mitochondrial reactive oxygen species (mROS) is strongly associated with mitochondrial and cellular oxidative damage, aging, and degenerative diseases. However, mROS also induces pathways of protection of mitochondria that slow aging, inhibit cell death, and increase lifespan. Recent studies show that the activation of the mitochondrial permeability transition pore (mPTP), which is triggered by mROS and mitochondrial calcium overloading, is enhanced in aged animals and humans and in aging-related degenerative diseases...
October 2017: Aging Cell
https://www.readbyqxmd.com/read/28737242/customers-perceptions-of-and-satisfaction-with-medicine-retail-outlet-services-in-addis-ababa-ethiopia-a-cross-sectional-study
#15
Dawit T Gebregeorgise, Tofik A Mohammed, Zebiba S Redi, Sofia Kälvemark Sporrong
OBJECTIVES: The aim of this study was to assess customers' perceptions of and satisfaction with MRO services in Addis Ababa and to explore factors associated with their satisfaction and reasons for visits. METHODS: A cross-sectional survey was conducted among customers selected from 28 MROs in Addis Ababa, using multi-stage sampling techniques. Simple descriptive statistics and multivariable logistic regression at 95% confidence interval were used for the analysis...
July 24, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28645202/effects-of-mobility-and-multimorbidity-on-inpatient-and-post-acute-health-care-utilization
#16
Kristine E Ensrud, Li-Yung Lui, Lisa Langsetmo, Tien N Vo, Brent C Taylor, Peggy M Cawthon, Meredith L Kilgore, Charles E McCulloch, Jane A Cauley, Marcia L Stefanick, Kristine Yaffe, Eric S Orwoll, John T Schousboe
Background: This study examines effects of mobility and multimorbidity on hospitalization and inpatient and post-acute care (PAC) facility days among older men. Methods: Prospective study of 1701 men (mean age 79.3 years) participating in MrOS Study Year 7 (Y7) examination (2007-2008) linked with their Medicare claims. At Y7, mobility ascertained by usual gait speed and categorized as poor, intermediate, or good. Multimorbidity quantified by applying Elixhauser algorithm to inpatient and outpatient claims and categorized as none, mild-moderate, or high...
June 22, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28583069/trajectories-of-the-relationships-of-physical-activity-with-body-composition-changes-in-older-men-the-mros-study
#17
Deepika R Laddu, Peggy M Cawthon, Neeta Parimi, Andrew R Hoffman, Eric Orwoll, Iva Miljkovic, Marcia L Stefanick
BACKGROUND: Excess adiposity gains and significant lean mass loss may be risk factors for chronic disease in old age. Long-term patterns of change in physical activity (PA) and their influence on body composition decline during aging has not been characterized. We evaluated the interrelationships of PA and body composition at the outset and over longitudinal follow-up to changes in older men. METHODS: Self-reported PA by the Physical Activity Scale for the Elderly (PASE), clinic body weight, and whole-body lean mass (LM) and fat mass, by dual-energy x-ray absorptiometry (DXA), were assessed in 5964 community-dwelling men aged ≥65 years at baseline (2000-2002) and at two subsequent clinic visits up until March 2009 (an average 4...
June 5, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28570003/age-of-onset-of-disease-in-subjects-with-severe-periodontitis-a%C3%A2-9-to-34-year-retrospective-study
#18
Sara Thorbert-Mros, Björn Cassel, Tord Berglundh
AIM: The aim was to retrospectively assess the age of onset of disease in a group of patients, 30-45 years of age, diagnosed with severe, generalised periodontitis. MATERIAL & METHODS: Seventy-four patients agreed to be part of the study. Patient files and radiographs of 42 patients were retrieved from >80 private and public dental clinics. Interproximal sites in radiographs presenting with identifiable cement-enamel junction (CEJ) and alveolar bone crest (BC) were analysed...
August 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28566123/funen-anorexia-nervosa-study-a-follow-up-study-on-outcome-mortality-quality-of-life-and-body-composition
#19
Laura Al-Dakhiel Winkler
Eating disorders (EDs) comprise a wide range of symptoms, with severe psychological and physical implications for the patient. EDs include anorexia nervosa (AN), bulimia nervosa (BN) and until 2013 eating disorder not otherwise specified (EDNOS), if criteria for AN or BN were not met. Patients suffering from an ED have poor prognosis, with more than half of AN patients not obtaining complete remission. One-fifth develops a chronic disease. EDs have an increased risk of premature death and patients with EDs report poorer quality of life (QoL) compared to both the general population and other psychiatric/somatic diseases...
June 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28557543/impaired-mitochondrial-microbicidal-responses-in-chronic-obstructive-pulmonary-disease-macrophages
#20
Martin A Bewley, Julie A Preston, Mohammed Mohasin, Helen M Marriott, Richard C Budd, Julie Swales, Paul Collini, David R Greaves, Ruth W Craig, Christopher E Brightling, Louise E Donnelly, Peter J Barnes, Dave Singh, Steven D Shapiro, Moira K B Whyte, David H Dockrell
RATIONALE: Chronic obstructive pulmonary disease (COPD) is characterized by impaired clearance of pulmonary bacteria. OBJECTIVES: The effect of COPD on alveolar macrophage (AM) microbicidal responses was investigated. METHODS: AMs were obtained from bronchoalveolar lavage from healthy donors or patients with COPD and challenged with opsonized serotype 14 Streptococcus pneumoniae. Cells were assessed for apoptosis, bactericidal activity, and mitochondrial reactive oxygen species (mROS) production...
October 1, 2017: American Journal of Respiratory and Critical Care Medicine
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