keyword
MENU ▼
Read by QxMD icon Read
search

mROS

keyword
https://www.readbyqxmd.com/read/29771295/the-association-between-objectively-measured-physical-activity-and-subsequent-health-care-utilization-in-older-men
#1
Lisa Langsetmo, Allyson M Kats, Peggy M Cawthon, Jane A Cauley, Tien N Vo, Brent C Taylor, Marcia L Stefanick, Nancy E Lane, Katie L Stone, Eric S Orwoll, John T Schousboe, Kristine E Ensrud
Background: To examine the associations between objective physical activity measures and subsequent health care utilization. Methods: We studied 1,283 men (mean age 79.1 years, SD 5.3) participating in the Osteoporotic Fractures in Men Study. Participants wore a SenseWear® Pro Armband monitor for 1 week. Data was summarized as daily (i) step counts, (ii) total energy expenditure, (iii) active energy expenditure, and (iv) activity time (sedentary, ≥ light, ≥ moderate)...
October 9, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29751130/association-of-high-resolution-peripheral-quantitative-computed-tomography-hr-pqct-bone-microarchitectural-parameters-with-previous-clinical-fracture-in-older-men-the-osteoporotic-fractures-in-men-mros-study
#2
Howard A Fink, Lisa Langsetmo, Tien N Vo, Eric S Orwoll, John T Schousboe, Kristine E Ensrud
High-resolution peripheral quantitative computed tomography (HR-pQCT) assesses both volumetric bone mineral density (vBMD) and trabecular and cortical microarchitecture. However, studies of the association of HR-pQCT parameters with fracture history have been small, predominantly limited to postmenopausal women, often performed limited adjustment for potential confounders including for BMD, and infrequently assessed strength or failure measures. We used data from the Osteoporotic Fractures in Men (MrOS) study, a prospective cohort study of community-dwelling men aged ≥65 years, to evaluate the association of distal radius, proximal (diaphyseal) tibia and distal tibia HR-pQCT parameters measured at the Year 14 (Y14) study visit with prior clinical fracture...
May 8, 2018: Bone
https://www.readbyqxmd.com/read/29750848/accelerated-bone-loss-in-older-men-effects-on-bone-microarchitecture-and-strength
#3
J A Cauley, A J Burghardt, S L Harrison, P M Cawthon, A V Schwartz, E Barrett Connor, Kristine E Ensrud, Lisa Langsetmo, S Majumdar, E Orwoll
Accelerated bone loss (ABL) shown on routine dual-energy X-ray absorptiometry (DXA) may be accompanied by microarchitectural changes, increased cortical porosity and lower bone strength. To test this hypothesis, we performed a cross-sectional study and used high resolution peripheral quantitative computed tomography (HR-pQCT) scans (SCANCO, Inc., Switzerland) to measure estimated bone strength and microarchitecture in the distal radius and distal and diaphyseal tibia. We studied 1628 men who attended the Year 14 exam of the Osteoporotic Fractures in Men (MrOS) study...
May 11, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29750841/high-serum-serotonin-predicts-increased-risk-for-hip-fracture-and-nonvertebral-osteoporotic-fractures-the-mros-sweden-study
#4
Hallgerdur Lind Kristjansdottir, Catharina Lewerin, Ulf H Lerner, Ewa Waern, Helena Johansson, Daniel Sundh, Magnus Karlsson, Steve R Cummings, Henrik Zetterberg, Mattias Lorentzon, Claes Ohlsson, Dan Mellström
Because several studies have implicated serotonin as a regulator of bone mass, we here explore its potential association on fracture risk and falls, as on bone mineral density (BMD) and muscle strength, in humans. Serum levels of serotonin were analyzed in 950 men (aged 69 to 81 years), participating in the Gothenburg part of the population-based study MrOS Sweden. Men taking selective serotonin reuptake inhibitors (SSRIs) had a mean value of 31.2 μg/L compared with 159.4 μg/L in those not taking SSRIs...
May 11, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29728373/frailty-as-a-risk-factor-for-cardiovascular-versus-noncardiovascular-mortality-in-older-men-results-from-the-mros-sleep-outcomes-of-sleep-disorders-in-older-men-study
#5
Selcuk Adabag, Tien N Vo, Lisa Langsetmo, John T Schousboe, Peggy M Cawthon, Katie L Stone, James M Shikany, Brent C Taylor, Kristine E Ensrud
BACKGROUND: Frailty is associated with greater mortality; however, whether frail patients primarily die of cardiovascular disease (CVD) or non-CVD causes is unknown. METHODS AND RESULTS: We assessed the cause of death in relation to frailty status, measured at baseline, among 3135 community-dwelling older men in the MrOS Sleep (Outcomes of Sleep Disorders in Older Men) study. Absolute probability and risk of CVD mortality associated with frailty status were estimated with traditional methods that used censoring and newer methods that considered non-CVD mortality as a competing risk...
May 4, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29701926/associations-between-lean-mass-muscle-strength-and-power-and-skeletal-size-density-and-strength-in-older-men
#6
Didier Chalhoub, Robert Boudreau, Susan Greenspan, Anne B Newman, Joseph Zmuda, Andrew W Frank-Wilson, Nayana Nagaraj, Andrew R Hoffman, Nancy E Lane, Marcia L Stefanick, Elizabeth Barrett-Connor, Tien Dam, Peggy Cawthon, Eric Orwoll, Jane A Cauley
Studies examining the relationship between muscle parameters and bone strength have not included multiple muscle measurements and/or both central and peripheral skeletal parameters. The purpose of this study was to explore the relationship between lean mass, muscle strength and power, and skeletal size, bone density and bone strength. We studied the association between appendicular lean mass (ALM), grip strength and leg power, and central quantitative computed tomography (QCT) parameters in 2,857 men aged 65 or older; peripheral QCT was available on a subset (N = 786)...
April 27, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29701911/dysmobility-syndrome-independently-increases-fracture-risk-in-the-osteoporotic-fractures-in-men-mros-prospective-cohort-study
#7
Bjoern Buehring, Karen E Hansen, Brian L Lewis, Steven R Cummings, Nancy E Lane, Neil Binkley, Kristine E Ensrud, Peggy M Cawthon
We proposed the term "dysmobility syndrome" (DS) to identify individuals with impaired musculoskeletal health, a risk factor for falls and fractures. Whether DS is associated with increased risk of incident fracture is unknown. The "Osteoporotic Fractures in Men" study enrolled 5994 men ages ≥65 years, between March 2000 and April 2002. We used baseline data to determine whether DS increased fracture risk, independent of FRAX. Men met DS criteria at baseline if they had ≥3 of the following: appendicular lean mass/height2 <7...
April 27, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29662768/lumbar-degenerative-spondylolisthesis-epidemiology-a-systematic-review-with-a-focus-on-gender-specific-and-age-specific-prevalence
#8
REVIEW
Yi Xiang J Wang, Zoltán Káplár, Min Deng, Jason C S Leung
The epidemiology of lumbar degenerative spondylolisthesis (DS) remains controversial. We performed a systematic review with the aim of gaining a better understanding of the prevalence of DS in the general population. The results showed that the prevalence of DS is very gender- and age-specific. Few women and men develop DS before they are 50 years old. After 50 years of age, both women and men begin to develop DS, with women having a faster rate of development than men. For elderly Chinese (≥ 65 years, mean age: 72...
October 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29624722/volumetric-bone-mineral-density-and-failure-load-of-distal-limbs-predict-incident-clinical-fracture-independent-of-frax-and-clinical-risk-factors-among-older-men
#9
Lisa Langsetmo, Katherine W Peters, Andrew J Burghardt, Kristine E Ensrud, Howard A Fink, Peggy M Cawthon, Jane A Cauley, John T Schousboe, Elizabeth Barrett-Connor, Eric S Orwoll
Our objective was to determine the associations of peripheral bone strength and microarchitecture with incident clinical and major osteoporotic fracture among older men after adjusting for major clinical risk factors. We used a prospective cohort study design with data from 1794 men (mean age 84.4 years) in the Osteoporotic Fractures in Men (MrOS) study. Eligible men attended the Year 14 visit, had high resolution peripheral quantitative computed tomography (HR-pQCT) scans of the distal radius and distal or diaphyseal tibia, DXA measured BMD, and were followed for mean 1...
April 6, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29590215/the-draft-genome-of-kipferlia-bialata-reveals-reductive-genome-evolution-in-fornicate-parasites
#10
Goro Tanifuji, Shun Takabayashi, Keitaro Kume, Mizue Takagi, Takuro Nakayama, Ryoma Kamikawa, Yuji Inagaki, Tetsuo Hashimoto
The fornicata (fornicates) is a eukaryotic group known to consist of free-living and parasitic organisms. Genome datasets of two model fornicate parasites Giardia intestinalis and Spironucleus salmonicida are well annotated, so far. The nuclear genomes of G. intestinalis assemblages and S. salmonicida are small in terms of the genome size and simple in genome structure. However, an ancestral genomic structure and gene contents, from which genomes of the fornicate parasites have evolved, remains to be clarified...
2018: PloS One
https://www.readbyqxmd.com/read/29584621/blocking-fatty-acid-fueled-mros-production-within-macrophages-alleviates-acute-gouty-inflammation
#11
Christopher J Hall, Leslie E Sanderson, Lisa M Lawrence, Bregina Pool, Maarten van der Kroef, Elina Ashimbayeva, Denver Britto, Jacquie L Harper, Graham J Lieschke, Jonathan W Astin, Kathryn E Crosier, Nicola Dalbeth, Philip S Crosier
Gout is the most common inflammatory arthritis affecting men. Acute gouty inflammation is triggered by monosodium urate (MSU) crystal deposition in and around joints that activates macrophages into a proinflammatory state, resulting in neutrophil recruitment. A complete understanding of how MSU crystals activate macrophages in vivo has been difficult because of limitations of live imaging this process in traditional animal models. By live imaging the macrophage and neutrophil response to MSU crystals within an intact host (larval zebrafish), we reveal that macrophage activation requires mitochondrial ROS (mROS) generated through fatty acid oxidation...
March 26, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29576797/inhibitory-effect-and-mechanism-of-arctium-lappa-extract-on-nlrp3-inflammasome-activation
#12
Young-Kyu Kim, Sushruta Koppula, Do-Wan Shim, Eun-Jung In, Su-Bin Kwak, Myong-Ki Kim, Sang-Hyeun Yu, Kwang-Ho Lee, Tae-Bong Kang
Arctium lappa (A. lappa) , Compositae, is considered a potential source of nutrition and is used as a traditional medicine in East Asian countries for centuries. Although several studies have shown its biological activities as an anti-inflammatory agent, there have been no reports on A. lappa with regard to regulatory role in inflammasome activation. The purpose of this study was to investigate the inhibitory effects of A. lappa extract (ALE) on NLRP3 inflammasome activation and explore the underlying mechanisms...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29572622/weight-loss-in-men-in-late-life-and-bone-strength-and-microarchitecture-a-prospective-study
#13
K E Ensrud, T N Vo, A J Burghardt, J T Schousboe, J A Cauley, B C Taylor, A R Hoffman, E S Orwoll, N E Lane, L Langsetmo
Weight loss in men in late life was associated with lower bone strength. In contrast, weight gain was not associated with a commensurate increase in bone strength. Future studies should measure concurrent changes in weight and parameters of bone strength and microarchitecture and evaluate potential causal pathways underlying these associations. INTRODUCTION: Our aim was to determine associations of weight loss with bone strength and microarchitecture. METHODS: We used data from 1723 community-dwelling men (mean age 84...
March 23, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29538422/bidesmosidic-betulin-saponin-bearing-l-rhamnopyranoside-moieties-induces-apoptosis-and-inhibition-of-lung-cancer-cells-growth-in-vitro-and-in-vivo
#14
Mouadh Mihoub, André Pichette, Balla Sylla, Charles Gauthier, Jean Legault
Betulin has a wide range of biological and pharmacological properties with its anticancer activity attracting most of the attention as it offers a possible alternative treatment to chemotherapy. However, betulin's in vivo biological effectiveness is limited by its poor solubility. As such, we synthesized polar glycosylated derivatives to increase its hydrosolubility and enhance its pharmacological properties. Among these synthesized compounds, 28-O-α-l-rhamnopyranosylbetulin 3β-O-α-l-rhamnopyranoside (Bi-L-RhamBet) was assessed for its cytotoxic effects against a suite of lung cancer cell lines...
2018: PloS One
https://www.readbyqxmd.com/read/29529273/the-association-between-trajectories-of-physical-activity-and-all-cause-and-cause-specific-mortality
#15
Deepika Laddu, Neeta Parimi, Jane A Cauley, Peggy M Cawthon, Kristine E Ensrud, Eric Orwoll, Marcia Stefanick, Lisa Langsetmo
Background: The benefits of physical activity (PA) for health have primarily been evaluated during midlife. Whether patterns of change in late-life PA associate with overall and cause-specific mortality remains unclear. Methods: We examined the association between PA trajectories and subsequent mortality among 3,767 men aged ≥ 65 years. Men self-reported PA using the Physical Activity Scale for the Elderly scale (PASE) at up to 4 time points from 2000 through 2009 (Year 7); mortality was assessed over an average of 7...
February 26, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29528519/serum-dhea-and-its-sulfate-are-associated-with-incident-fall-risk-in-older-men-the-mros-sweden-study
#16
Claes Ohlsson, Maria Nethander, Magnus K Karlsson, Björn E Rosengren, Eva Ribom, Dan Mellström, Liesbeth Vandenput
The adrenal-derived hormones dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are the most abundant circulating hormones and their levels decline substantially with age. Many of the actions of DHEAS are considered to be mediated through metabolism into androgens and estrogens in peripheral target tissues. The predictive value of serum DHEA and DHEAS for the likelihood of falling is unknown. The aim of this study was, therefore, to assess the associations between baseline DHEA and DHEAS levels and incident fall risk in a large cohort of older men...
March 12, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29514094/an-essential-role-for-ecsit-in-mitochondrial-complex-i-assembly-and-mitophagy-in-macrophages
#17
Flávia R G Carneiro, Alice Lepelley, John J Seeley, Matthew S Hayden, Sankar Ghosh
ECSIT is a mitochondrial complex I (CI)-associated protein that has been shown to regulate the production of mitochondrial reactive oxygen species (mROS) following engagement of Toll-like receptors (TLRs). We have generated an Ecsit conditional knockout (CKO) mouse strain to study the in vivo role of ECSIT. ECSIT deletion results in profound alteration of macrophage metabolism, leading to a striking shift to reliance on glycolysis, complete disruption of CI activity, and loss of the CI holoenzyme and multiple subassemblies...
March 6, 2018: Cell Reports
https://www.readbyqxmd.com/read/29477360/mros-txnip-axis-activates-nlrp3-inflammasome-to-mediate-renal-injury-during-ischemic-aki
#18
Yi Wen, Yi-Ran Liu, Tao-Tao Tang, Ming-Ming Pan, Sheng-Chun Xu, Kun-Ling Ma, Lin-Li Lv, Hong Liu, Bi-Cheng Liu
Ischemia/reperfusion (I/R) is a critical risk factor for acute kidney injury (AKI). Recent studies provided evidence that tubular epithelial cells (TEC)-associated inflammation aggravates kidney injury and impairs tissue repair after I/R injury. Here we demonstrated that the Nod-like receptor protein 3 (NLRP3) inflammasome is activated by mitochondrial reactive oxygen species (mROS) during I/R injury via direct interactions between the inflammasome and thioredoxin-interacting protein (TXNIP). Firstly, we found that NLRP3 inflammasome activation was induced by I/R injury, peaking at day 3 after reperfusion...
May 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29450584/dietary-patterns-and-longitudinal-change-in-hip-bone-mineral-density-among-older-men
#19
T S Rogers, S Harrison, S Judd, E S Orwoll, L M Marshall, J Shannon, L Langsetmo, N E Lane, J M Shikany
Studying dietary patterns is often more informative than individual nutrients or foods. We found that a Prudent dietary pattern (rich in vegetables and fish) was associated with reduced loss of total hip BMD in older men. A Prudent dietary pattern may be a potential lifestyle strategy for minimizing bone loss. INTRODUCTION: This study aimed to identify baseline dietary patterns using factor analysis in a cohort of older men and to evaluate whether the dietary patterns were associated with bone mineral density change (%ΔBMD) at the total hip and femoral neck over time...
February 15, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29399943/high-throughput-serum-proteomics-for-the-identification-of-protein-biomarkers-of-mortality-in-older-men
#20
Eric S Orwoll, Jack Wiedrick, Jon Jacobs, Erin S Baker, Paul Piehowski, Vladislav Petyuk, Yuqian Gao, Tujin Shi, Richard D Smith, Douglas C Bauer, Steven R Cummings, Carrie M Nielson, Jodi Lapidus
The biological perturbations associated with incident mortality are not well elucidated, and there are limited biomarkers for the prediction of mortality. We used a novel high-throughput proteomics approach to identify serum peptides and proteins associated with 5-year mortality in community-dwelling men age ≥65 years who participated in a longitudinal observational study of musculoskeletal aging (Osteoporotic Fractures in Men: MrOS). In a discovery phase, serum specimens collected at baseline in 2473 men were analyzed using liquid chromatography-ion mobility-mass spectrometry, and incident mortality in the subsequent 5 years was ascertained by tri-annual questionnaire...
April 2018: Aging Cell
keyword
keyword
16480
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"