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https://www.readbyqxmd.com/read/28212898/low-serum-iron-is-associated-with-high-serum-intact-fgf23-in-elderly-men-the-swedish-mros-study
#1
Catharina Lewerin, Östen Ljunggren, Herman Nilsson-Ehle, Magnus K Karlsson, Hans Herlitz, Mattias Lorentzon, Claes Ohlsson, Dan Mellström
BACKGROUND: Fibroblast growth factor (FGF23) is a protein that is produced by osteoblasts and osteocytes. Increased serum levels of FGF23 have been associated with increased risks of osteoporotic fractures and cardiovascular disease, particularly in participants with poor renal function. Serum iron (Fe) has been suggested as a regulator of FGF23 homeostasis. OBJECTIVE: To determine whether Fe and iron status are determinants of the levels of intact FGF23 (iFGF23) in elderly men...
February 14, 2017: Bone
https://www.readbyqxmd.com/read/28199705/associations-of-incident-cardiovascular-events-with-restless-legs-syndrome-and-periodic-leg-movements-of-sleep-in-older-men-for-the-outcomes-of-sleep-disorders-in-older-men-study-mros-sleep-study
#2
John W Winkelman, Terri Blackwell, Katie Stone, Sonia Ancoli-Israel, Susan Redline
No abstract text is available yet for this article.
February 11, 2017: Sleep
https://www.readbyqxmd.com/read/28197854/mitochondrial-complex-i-activity-is-conditioned-by-supercomplex-i-iii2-iv-assembly-in-brain-cells-relevance-for-parkinson-s-disease
#3
Irene Lopez-Fabuel, Monica Resch-Beusher, Monica Carabias-Carrasco, Angeles Almeida, Juan P Bolaños
The assembly of complex I (CI) with complexes III (CIII) and IV (CIV) of the mitochondrial respiratory chain (MRC) to configure I-III- or I-III-IV-containing supercomplexes (SCs) regulates mitochondrial energy efficiency and reactive oxygen species (mROS) production. However, whether the occurrence of SCs impacts on CI specific activity remains unknown to our knowledge. To investigate this issue, here we determined CI activity in primary neurons and astrocytes, cultured under identical antioxidants-free medium, from two mouse strains (C57Bl/6 and CBA) and Wistar rat, i...
February 14, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28181652/arb-users-exhibit-a-lower-fracture-incidence-than-ace-inhibitor-users-among-older-hypertensive-men
#4
Timothy Kwok, Jason Leung, Elizabeth Barrett-Connor
No abstract text is available yet for this article.
January 10, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28181641/risk-factors-for-low-back-pain-and-sciatica-in-elderly-men-the-mros-sweden-study
#5
Mehrsa Kherad, Björn E Rosengren, Ralph Hasserius, Jan-Åke Nilsson, Inga Redlund-Johnell, Claes Ohlsson, Dan Mellström, Mattiaz Lorentzon, Östen Ljunggren, Magnus K Karlsson
No abstract text is available yet for this article.
January 8, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28179169/vertebral-bone-marrow-fat-bone-mineral-density-and-diabetes-the-osteoporotic-fractures-in-men-mros-study
#6
Yahtyng Sheu, Francesca Amati, Ann V Schwartz, Michelle E Danielson, Xiaojuan Li, Robert Boudreau, Jane A Cauley
Elevated vertebral bone marrow fat (BMF) among individuals with osteoporosis has been established in histomorphometric studies. Several studies have found a negative correlation between BMF and bone mineral density (BMD) at the spine in men and women across different age groups. Animal studies have also observed bone loss with increased BMF in mice with induced diabetes. Our study objective was to test the hypothesis that the association between BMF and BMD varies by diabetic status. We performed a cross-sectional study of 156 men aged 74-96years from the Osteoporotic Fractures in Men study at the Pittsburgh clinical site...
February 4, 2017: Bone
https://www.readbyqxmd.com/read/28177140/serum-phosphate-is-associated-with-fracture-risk-the-rotterdam-study-and-mros
#7
N Campos-Obando, W N H Koek, E R Hooker, B C J van der Eerden, H A Pols, A Hofman, J P T M van Leeuwen, A G Uitterlinden, C M Nielson, M C Zillikens
Extreme phosphate levels (P) have been associated with mineralization defects and increased fracture risk. Whether P within normal range is related to bone health in the general population is not well understood. To investigate the association of P with bone mineral density (BMD) and fracture risk, we assessed two population-based cohorts: the Dutch Rotterdam Study (RS-I, RS-II, RS-III; n = 6791) and the US Osteoporotic Fractures in Men (MrOS; n = 5425) study. The relationship of P with lumbar spine (LS) and femoral neck (FN) BMD was tested in all cohorts via linear models; fracture risk was tested in RS-I, RS-II and MrOS through Cox models, after follow-up of 8...
February 8, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28176139/lower-prostate-cancer-risk-in-swedish-men-with-the-androgen-receptor-e213-a-allele
#8
Magdalena Bentmar Holgersson, Yasir Ruhayel, Magnus Karlsson, Aleksander Giwercman, Anders Bjartell, Claes Ohlsson, Dan Mellström, Östen Ljunggren, Mohammad-Ali Haghsheno, Jan-Erik Damber, Yvonne Lundberg Giwercman
BACKGROUND: In a previous population-based study on 3369 European men with self-reported prostate cancer (PCa), it was shown that androgen receptor (AR) haplotype designated H2 was associated with high levels of serum PSA (prostate-specific antigen) concentration, and, at the same time, with low risk for PCa. The aim of this study was to replicate this finding in other cohorts, with registry-based cancer diagnosis. METHODS: Using data from two population-based cohorts; the Malmö Diet and Cancer Study (MDCS, n = 12,121) and the Swedish Osteoporotic fractures in men study (MrOS, n = 1,120), 628 men with PCa and 1,374 controls were identified and genotyped...
March 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28158467/daily-patterns-of-accelerometer-activity-predict-changes-in-sleep-cognition-and-mortality-in-older-men
#9
Jamie M Zeitzer, Terri Blackwell, Andrew R Hoffman, Steve Cummings, Sonia Ancoli-Israel, Katie Stone
No abstract text is available yet for this article.
February 3, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28135013/low-testosterone-but-not-estradiol-is-associated-with-incident-falls-in-older-men-the-international-mros-study
#10
Liesbeth Vandenput, Dan Mellström, Gail A Laughlin, Peggy M Cawthon, Jane A Cauley, Andrew R Hoffman, Magnus K Karlsson, Björn E Rosengren, Östen Ljunggren, Maria Nethander, Anna L Eriksson, Mattias Lorentzon, Jason Leung, Timothy Kwok, Eric S Orwoll, Claes Ohlsson
Fracture risk is determined by bone strength and the risk of falls. The relationship between serum sex steroids and bone strength parameters in men is well known, while the predictive value of sex steroids for falls is less studied. The aim of this study was to assess the associations between serum testosterone (T) and estradiol (E2) and the likelihood of falls. Older men (aged ≥65 years) from the US (n = 1919), Sweden (n = 2495), and Hong Kong (n = 1469) participating in the Osteoporotic Fractures in men study had baseline T and E2 analyzed by mass spectrometry...
January 30, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28063379/oxidative-stress-mitochondrial-abnormalities-and-antioxidant-defense-in-ataxia-telangiectasia-bloom-syndrome-and-nijmegen-breakage-syndrome
#11
REVIEW
Mateusz Maciejczyk, Bozena Mikoluc, Barbara Pietrucha, Edyta Heropolitanska-Pliszka, Malgorzata Pac, Radosław Motkowski, Halina Car
Rare pleiotropic genetic disorders, Ataxia-telangiectasia (A-T), Bloom syndrome (BS) and Nijmegen breakage syndrome (NBS) are characterised by immunodeficiency, extreme radiosensitivity, higher cancer susceptibility, premature aging, neurodegeneration and insulin resistance. Some of these functional abnormalities can be explained by aberrant DNA damage response and chromosomal instability. It has been suggested that one possible common denominator of these conditions could be chronic oxidative stress caused by endogenous ROS overproduction and impairment of mitochondrial homeostasis...
April 2017: Redox Biology
https://www.readbyqxmd.com/read/28035213/peroxiredoxin-3-is-involved-in-bactericidal-activity-through-the-regulation-of-mitochondrial-reactive-oxygen-species
#12
Sena Lee, Sae Mi Wi, Yoon Min, Ki-Young Lee
Peroxiredoxin-3 (Prdx3) is a mitochondrial protein of the thioredoxin family of antioxidant peroxidases and is the principal peroxidase responsible for metabolizing mitochondrial hydrogen peroxide. Recent reports have shown that mitochondrial reactive oxygen species (mROS) contribute to macrophage-mediated bactericidal activity in response to Toll-like receptors. Herein, we investigated the functional effect of Prdx3 in bactericidal activity. The mitochondrial localization of Prdx3 in HEK293T cells was confirmed by cell fractionation and confocal microscopy analyses...
December 2016: Immune Network
https://www.readbyqxmd.com/read/28013364/rest-activity-patterns-and-falls-and-fractures-in-older-men
#13
Tara S Rogers, Terri L Blackwell, Nancy E Lane, Greg Tranah, Eric S Orwoll, Jane A Cauley, Sonia Ancoli-Israel, Katie L Stone, Steven R Cummings, Peggy M Cawthon
: Dysregulated rest-activity rhythm (RAR) patterns have been associated with several health conditions in older adults. This study showed that later acrophase was associated with a modestly greater risk of falls but not fractures in elderly men. Associations between dysregulated RAR patterns and osteoporosis risk warrant further investigation. PURPOSE: The purpose of this study was to investigate the relationship between rest-activity rhythm (RAR) patterns and risk of falls/fractures in older men...
December 24, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/28012217/association-of-increased-urinary-albumin-with-risk-of-incident-clinical-fracture-and-rate-of-hip-bone-loss-the-osteoporotic-fractures-in-men-study
#14
Howard A Fink, Tien N Vo, Lisa Langsetmo, Joshua I Barzilay, Jane A Cauley, John T Schousboe, Eric S Orwoll, Muna T Canales, Areef Ishani, Nancy E Lane, Kristine E Ensrud
Prior studies suggest that increased urine albumin is associated with a heightened fracture risk in women, but results in men are unclear. We used data from MrOS, a prospective cohort study of community-dwelling men aged ≥65 years, to evaluate the association of increased urine albumin with subsequent fractures and annualized rate of hip bone loss. We calculated albumin/creatinine ratio (ACR) from urine collected at the 2003-05 visit. Subsequent clinical fractures were ascertained from triannual questionnaires and centrally adjudicated by review of radiographic reports...
December 24, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28001907/ionizing-radiation-induces-innate-immune-responses-in-macrophages-by-generation-of-mitochondrial-reactive-oxygen-species
#15
Sup Kim, Jin Ho Choe, Gippeum Joy Lee, Yi Sak Kim, Soo Yeon Kim, Hye-Mi Lee, Hyo Sun Jin, Tae Sung Kim, Jin-Man Kim, Moon-June Cho, Eui-Cheol Shin, Eun-Kyeong Jo, Jun-Sang Kim
During radiotherapy for tumors, the innate immune system also responds to ionizing radiation and induces immune modulation. However, little is known about the molecular mechanisms by which radiation modulates innate immune responses. In this study, we observed that radiation triggered the generation of mitochondrial reactive oxygen species (mROS), leading to innate immune responses in murine bone marrow-derived macrophages (BMDM). Radiation-induced mROS was essential for robust induction of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and IL-12p40 mRNA and protein in BMDM...
January 2017: Radiation Research
https://www.readbyqxmd.com/read/27943394/the-association-between-protein-intake-by-source-and-osteoporotic-fracture-in-older-men-a-prospective-cohort-study
#16
Lisa Langsetmo, James M Shikany, Peggy M Cawthon, Jane A Cauley, Brent C Taylor, Tien N Vo, Douglas C Bauer, Eric S Orwoll, John T Schousboe, Kristine E Ensrud
Dietary protein is a potentially modifiable risk factor for fracture. Our objectives were to assess the association of protein intake with incident fracture among older men and whether these associations varied by protein source or by skeletal site. We studied a longitudinal cohort of 5875 men (mean age 73.6 ± 5.9 years) in the Osteoporotic Fractures in Men (MrOS) study. At baseline, protein intake was assessed as percent of total energy intake (TEI) with mean intake from all sources = 16.1%TEI. Incident clinical fractures were confirmed by physician review of medical records...
December 12, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27938334/prevalent-peripheral-arterial-disease-and-inflammatory-burden
#17
Jane A Cauley, Ahmed M Kassem, Nancy E Lane, Sara Thorson
BACKGROUND: Strong evidence implicates inflammation in the development of atherosclerotic heart disease but less is known about peripheral arterial disease (PAD). Our objective was to test the hypothesis that a composite index of inflammatory burden is associated with PAD. METHODS: Cross-sectional analysis of a randomly-selected group of 903 community-dwelling men in the MrOS cohort recruited between 2000 and 2002. Using blood samples, we measured seven cytokines and related these levels to prevalent PAD (ankle-brachial index (ABI) <0...
December 9, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27930804/increased-mitochondrial-ros-generation-mediates-the-loss-of-pvat-anticontractile-effect-in-hfd-treated-obese-mice
#18
Rafael Menezes da Costa, Rafael S Fais, Carlos R P Dechandt, Paulo Louzada-Junior, Luciane C Alberici, Núbia S Lobato, Rita C Tostes
Obesity is associated with structural and functional changes in the perivascular adipose tissue (PVAT), favoring the release of reactive oxygen species (ROS), vasoconstrictor and proinflammatory factors. Tumor necrosis factor alpha (TNF-α) induces vascular dysfunction and is produced by the PVAT. We tested the hypothesis that obesity-associated PVAT dysfunction is mediated by augmented mitochondrial ROS (mROS) generation due to increased TNF-α production in this tissue. Aortae from high fat diet (HFD)-fed obese mice displayed increased contractions to phenylephrine (PE) and loss of PVAT anticontractile effect...
December 8, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27889439/when-a-gold-standard-isn-t-so-golden-lack-of-prediction-of-subjective-sleep-quality-from-sleep-polysomnography
#19
Katherine A Kaplan, Jason Hirshman, Beatriz Hernandez, Marcia L Stefanick, Andrew R Hoffman, Susan Redline, Sonia Ancoli-Israel, Katie Stone, Leah Friedman, Jamie M Zeitzer
BACKGROUND: Reports of subjective sleep quality are frequently collected in research and clinical practice. It is unclear, however, how well polysomnographic measures of sleep correlate with subjective reports of prior-night sleep quality in elderly men and women. Furthermore, the relative importance of various polysomnographic, demographic and clinical characteristics in predicting subjective sleep quality is not known. We sought to determine the correlates of subjective sleep quality in older adults using more recently developed machine learning algorithms that are suitable for selecting and ranking important variables...
February 2017: Biological Psychology
https://www.readbyqxmd.com/read/27852636/a-prospective-study-of-back-pain-and-risk-of-falls-among-older-community-dwelling-men
#20
Lynn M Marshall, Stephanie Litwack-Harrison, Una E Makris, Deborah M Kado, Peggy M Cawthon, Richard A Deyo, Nels L Carlson, Michael C Nevitt
BACKGROUND: Musculoskeletal pain is associated with increased fall risk among older men. However, the association of back pain, the most prevalent type of pain in this population, and fall risk is unknown. METHODS: We conducted a prospective investigation among 5,568 community-dwelling U.S. men at least 65 years of age from the Osteoporotic Fractures in Men Study (MrOS). Baseline questionnaires inquired about back pain and its location (such as low back), severity, and frequency in the past year...
November 16, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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