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https://www.readbyqxmd.com/read/30087902/statistical-structural-analysis-of-familial-spontaneous-epileptic-cats-using-voxel-based-morphometry
#1
Yuji Hamamoto, Daisuke Hasegawa, Yoshihiko Yu, Rikako Asada, Shunta Mizoguchi, Takayuki Kuwabara, Masae Wada, Aki Fujiwara-Igarashi, Michio Fujita
Voxel-based morphometry (VBM) based on high resolution three-dimensional data of magnetic resonance imaging has been developed as a statistical morphometric imaging analysis method to locate brain abnormalities in humans. Recently, VBM has been used for human patients with psychological or neurological disorders such as Alzheimer's disease, Parkinson's disease, and epilepsy. Traditional volumetry using region of interest (ROI) is performed manually and the observer needs detailed knowledge of the neuroanatomy having to trace objects of interest on many slices which can cause artificial errors...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/30018294/apc2-controls-dendrite-development-by-promoting-microtubule-dynamics
#2
Olga I Kahn, Philipp Schätzle, Dieudonnée van de Willige, Roderick P Tas, Feline W Lindhout, Sybren Portegies, Lukas C Kapitein, Casper C Hoogenraad
Mixed polarity microtubule organization is the signature characteristic of vertebrate dendrites. Oppositely oriented microtubules form the basis for selective cargo trafficking in neurons, however the mechanisms that establish and maintain this organization are unclear. Here, we show that APC2, the brain-specific homolog of tumor-suppressor protein adenomatous polyposis coli (APC), promotes dynamics of minus-end-out microtubules in dendrites. We found that APC2 localizes as distinct clusters along microtubule bundles in dendrites and that this localization is driven by LC8-binding and two separate microtubule-interacting domains...
July 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/30017081/molecular-assessment-of-neospora-caninum-and-toxoplasma-gondii-in-hooded-crows-corvus-cornix-in-tehran-iran
#3
Amir Abdoli, Mohsen Arbabi, Majid Pirestani, Mehran Mirzaghavami, Fatemeh Ghaffarifar, Abdolhossein Dalimi, Javid Sadraei
Neospora caninum and Toxoplasma gondii are two closely related protozoan parasites that have been detected from various species of bird hosts. However, little is known about the prevalence of N. caninum and T. gondii in crows. Hence, we examined the molecular frequency of N. caninum and T. gondii in the brain samples of hooded crows (Corvus cornix) that collected from different public parks of Tehran, Iran by nested-PCR method. We used the primers targeting the Nc5 and GRA6 genes for detection of N. caninum and T...
April 2018: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/29958521/hippocampal-necrosis-and-sclerosis-in-cats-a-retrospective-study-of-35-cases
#4
Andrea Klang, Sandra Högler, Nora Nedorost, Christiane Weissenbacher-Lang, Ákos Pákozdy, Bethan Lang, Herbert Weissenböck
Hippocampal necrosis and hippocampal sclerosis in cats is a neuropathological entity which is a major concern in feline epilepsy. The aim of our study was to identify associated pathologic brain lesions possibly serving as aetiological triggers in this condition. Therefore, the formalin-fixed and paraffin waxembedded brain tissue of 35 cats diagnosed with hippocampal necrosis or sclerosis was examined retrospectively. In 26 cats inflammatory infiltrates could be found in the hippocampus or adjacent brain regions...
June 2018: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/29934581/linear-cyclodextrin-polymer-prodrugs-as-novel-therapeutics-for-niemann-pick-type-c1-disorder
#5
Aditya Kulkarni, Paola Caporali, Atul Dolas, Soniya Johny, Sandeep Goyal, Jessica Dragotto, Alberto Macone, Ramesh Jayaraman, Maria Teresa Fiorenza
Niemann-Pick Type C1 disorder (NPC) is a rare lysosomal storage disease characterized by the accumulation of cholesterol in lysosomes. NPC has no FDA approved treatments yet, however 2-hydroxypropyl-β-cyclodextrin (HPβCD) has shown efficacy for treating the disease in both mouse and feline NPC models and is currently being investigated in late stage clinical trials. Despite promising results, therapeutic use of HPβCD is limited by the need for high doses, ototoxicity and intrathecal administration. These limitations can be attributed to its poor pharmacokinetic profile...
June 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29846444/toxoplasma-gondii-isolation-biological-and-molecular-characterisation-of-samples-from-free-range-gallus-gallus-domesticus-from-countryside-southeast-brazil
#6
Tamiris Cristine Ribeiro Ferreira, Julyana Cerqueira Buery, Narcisa Imaculada Brant Moreira, Claudiney Biral Santos, Júlia Gatti Ladeia Costa, Lorena Velozo Pinto, Ramon Castro de Araújo Baraviera, Ricardo Wagner Almeida Vitor, Blima Fux
Toxoplasma gondii presents a high prevalence worldwide, infecting several animals. Felines are considered the definitive hosts and among the intermediate hosts we highlight mammals and birds. The man can become infected by ingesting tissue cysts present in birds and mammals. Biological and molecular aspects of T. gondii allows a better understanding of the epidemiology of toxoplasmosis. This work is a serologic screening of 58 chickens grown (Gallus gallus domesticus) for human consumption in Espírito Santo State, by means of indirect haemagglutination assay (IHA)...
May 24, 2018: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/29657017/assessment-of-the-antigenic-and-neuroprotective-activity-of-the-subunit-anti-toxoplasma-vaccine-in-t-gondii-experimentally-infected-mice
#7
Justyna Gatkowska, Marek Wieczorek, Bożena Dziadek, Katarzyna Dzitko, Jarosław Dziadek, Henryka Długońska
The aim of this study was to evaluate the immunogenic and immunoprotective activities and to determine the neuroprotective capacity of the tetravalent vaccine containing selected recombinant T. gondii antigens (ROP2 + ROP4 + SAG1 + MAG1) administered with safe adjuvants (MPL and alum) using male and female inbred mice. The tested antigenic combination provided partial protection against brain cyst formation, especially in males (reduction in cyst burden by 72%). The decrease in cyst burden was observed for the whole brain as well as for specified brain regions associated with natural defensive behaviors, emotion processing and integration of motor and sensory stimuli...
April 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29595359/feline-hyperaesthesia-syndrome-with-self-trauma-to-the-tail-retrospective-study-of-seven-cases-and-proposal-for-integrated-multidisciplinary-diagnostic-approach
#8
Pablo Amengual Batle, Clare Rusbridge, Tim Nuttall, Sarah Heath, Katia Marioni-Henry
Case series summary This was a retrospective study on the clinical features and response to treatment in seven cats with feline hyperaesthesia syndrome (FHS) and tail mutilation. FHS is a poorly understood disorder characterised by skin rippling over the dorsal lumbar area, episodes of jumping and running, excessive vocalisation, and tail chasing and self-trauma. The majority of the cats were young, with a median age of 1 year at the onset of clinical signs, male (n = 6) and with access to the outdoors (n = 5)...
March 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29499762/systematic-review-of-antiepileptic-drugs-safety-and-effectiveness-in-feline-epilepsy
#9
Marios Charalambous, Akos Pakozdy, Sofie F M Bhatti, Holger A Volk
BACKGROUND: Understanding the efficacy and safety profile of antiepileptic drugs (AEDs) in feline epilepsy is a crucial consideration for managing this important brain disease. However, there is a lack of information about the treatment of feline epilepsy and therefore a systematic review was constructed to assess current evidence for the AEDs' efficacy and tolerability in cats. The methods and materials of our former systematic reviews in canine epilepsy were mostly mirrored for the current systematic review in cats...
March 2, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29487747/extranodal-non-b-non-t-cell-lymphoma-with-bilateral-tympanic-bulla-involvement-in-a-cat
#10
Austin T Kerns, Kelsey A Brakel, Christopher Premanandan, Ashlie Saffire, Sarah A Moore
Case summary: A 9-year-old spayed female domestic shorthair cat with clinical signs suggestive of chronic recurrent otitis media and recent seizures was presented with multifocal nervous system disease, including bilateral central and/or peripheral vestibular, cerebellar and forebrain deficits. Prior to presentation, there was inadequate improvement after 6 weeks of treatment for bilateral middle ear effusion from which a highly susceptible Staphylococcus species was cultured. This was followed by the development of seizures...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29411701/a-retrospective-study-of-the-neuropathology-and-diagnosis-of-naturally-occurring-feline-infectious-peritonitis
#11
Daniel R Rissi
Feline infectious peritonitis (FIP) is one of the most important viral diseases of cats worldwide. Our study describes the neuropathology and the diagnostic features of 26 cases of FIP in domestic cats. The average age of affected individuals was 11.8 mo, and there was no sex or breed predisposition. Clinical neurologic signs were noted in 22 cases, and rabies was clinically suspected in 11 cases. Twenty cats had lesions in multiple organs, and 6 cats had lesions only in the brain. Gross neuropathologic changes occurred in 15 cases and consisted of hydrocephalus (10 cases), cerebellar herniation through the foramen magnum (6 cases), cerebral swelling with flattening of gyri (2 cases), and accumulation of fibrin within ventricles (2 cases) or leptomeninges (1 case)...
May 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29394131/epitope-mapping-of-monoclonal-antibody-pmab-52-against-cat-podoplanin
#12
Yao-Wen Chang, Mika K Kaneko, Shinji Yamada, Yukinari Kato
The mucin-type membrane glycoprotein podoplanin (PDPN) is frequently overexpressed in numerous malignant cancers, including squamous cell carcinoma, germinal neoplasia, mesothelioma, lung cancer, oral cancer, and brain tumor. PDPN expression is strongly associated with cancer progression and poor prognosis. Furthermore, PDPN binds to C-type lectin-like receptor 2 (CLEC-2) on platelets, followed by PDPN-mediated platelet aggregation to facilitate tumor metastasis. We have previously reported a novel anti-cat PDPN (cPDPN) monoclonal antibody (mAb), PMab-52, which specifically detects cPDPN using flow cytometry analysis and successfully identifies cPDPN in feline squamous cell carcinomas...
April 2018: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29346563/lc3-immunostaining-in-the-inferior-olivary-nuclei-of-cats-with-niemann-pick-disease-type-c1-is-associated-with-patterned-purkinje-cell-loss
#13
Brittney L Gurda, Jessica H Bagel, Samantha J Fisher, Mark L Schultz, Andrew P Lieberman, Peter Hand, Charles H Vite, Gary P Swain
The feline model of Niemann-Pick disease, type C1 (NPC1) recapitulates the clinical, neuropathological, and biochemical abnormalities present in children with NPC1. The hallmarks of disease are the lysosomal storage of unesterified cholesterol and multiple sphingolipids in neurons, and the spatial and temporal distribution of Purkinje cell death. In feline NPC1 brain, microtubule-associated protein 1 light chain 3 (LC3) accumulations, indicating autophagosomes, were found within axons and presynaptic terminals...
March 1, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29247305/neurologic-disease-in-feline-immunodeficiency-virus-infection-disease-mechanisms-and-therapeutic-interventions-for-neuroaids
#14
Christopher Power
Feline immunodeficiency virus (FIV) is a lentivirus that causes immunosuppression through virus-mediated CD4+ T cell depletion in feline species. FIV infection is complicated by virus-induced disease in the nervous system. FIV enters the brain soon after primary infection and is detected as FIV-encoded RNA, DNA, and proteins in microglia, macrophages, and astrocytes. FIV infection activates neuroinflammatory pathways including cytokines, chemokines, proteases, and ROS with accompanying neuronal injury and loss...
April 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29093718/selective-limbic-blood-brain-barrier-breakdown-in-a-feline-model-of-limbic-encephalitis-with-lgi1-antibodies
#15
Anna R Tröscher, Andrea Klang, Maria French, Lucía Quemada-Garrido, Sibylle Maria Kneissl, Christian G Bien, Ákos Pákozdy, Jan Bauer
Human leucine-rich glioma-inactivated protein 1 encephalitis (LGI1) is an autoimmune limbic encephalitis in which serum and cerebrospinal fluid contain antibodies targeting LGI1, a protein of the voltage gated potassium channel (VGKC) complex. Recently, we showed that a feline model of limbic encephalitis with LGI1 antibodies, called feline complex partial seizures with orofacial involvement (FEPSO), is highly comparable to human LGI1 encephalitis. In human LGI1 encephalitis, neuropathological investigations are difficult because very little material is available...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29090969/expression-of-cat-podoplanin-in-feline-squamous-cell-carcinomas
#16
Shunsuke Itai, Shinji Yamada, Mika K Kaneko, Hiroyuki Harada, Yumiko Kagawa, Satoru Konnai, Yukinari Kato
Oral squamous cell carcinoma is an aggressive tumor in cats; however, molecular-targeted therapies against this tumor, including antibody therapy, have not been developed. Sensitive and specific monoclonal antibodies (mAbs) against highly expressed membrane proteins are needed to develop antibody therapies. Podoplanin, a type I transmembrane glycoprotein, is expressed in many human malignant tumors, including brain tumor, esophageal cancer, lung cancer, mesothelioma, and oral cancer. Podoplanin binds to C-type lectin-like receptor-2 (CLEC-2) and activates platelet aggregation, which is involved in cancer metastasis...
December 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29037435/feline-epilepsy
#17
REVIEW
Heidi Barnes Heller
Seizures occur commonly in cats and can be classified as idiopathic epilepsy, structural epilepsy, or reactive seizures. Pursuit of a diagnosis may include a complete blood count, serum biochemistry, brain MRI, and cerebrospinal fluid analysis as indicated. Antiepileptic drugs should be considered if a cat is having frequent seizures, or any 1 seizure longer than 5 minutes. Phenobarbital is often the drug of choice; however, levetiracetam may be more useful for certain types of epilepsy in cats. Long-term prognosis depends on the underlying diagnosis and response to therapy...
January 2018: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28901423/a-multi%C3%A2-targeted-tyrosine-kinase-inhibitor-lenvatinib-for-the-treatment-of-mice-with-advanced-glioblastoma
#18
Jia Li, Chang-Lin Zou, Zhi-Ming Zhang, Lian-Jie Lv, Hai-Bo Qiao, Xiu-Ju Chen
Glioblastoma is the most aggressive primary brain tumor that originates from the glial cells in adults. Aberrant angiogenesis is essential for malignant glioblastoma tumorigenesis, development and metastasis. Lenvatinib is a multi‑targeted anticancer agent that targets of receptor tyrosine kinases including vascular endothelial growth factor receptor 1 and 2, fibroblast growth factor receptor 1, platelet‑derived growth factor receptor β and v‑kit Hardy‑Zuckerman 4 feline sarcoma viral oncogene homolog...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28749325/central-and-peripheral-reservoirs-of-feline-immunodeficiency-virus-in-cats-a-review
#19
REVIEW
Chrissy D Eckstrand, Ellen E Sparger, Brian G Murphy
Infection with feline immunodeficiency virus (FIV), a lentivirus similar to human immunodeficiency virus (HIV), results in lifelong viral persistence and progressive immunopathology in the cat. FIV has the ability to infect and produce infectious virus in a number of different cell types. FIV provirus can also be maintained in a replication-competent but transcriptionally quiescent state, facilitating viral persistence over time. Immediately after the initial infection, FIV infection quickly disseminates to many anatomical compartments within the host including lymphoid organs, gastrointestinal tract and brain...
August 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28613179/unsupervised-learning-of-spike-patterns-for-seizure-detection-and-wavefront-estimation-of-high-resolution-micro-electrocorticographic-mu-ecog-data
#20
Yilin Song, Yao Wang, Jonathan Viventi
For the past few years, we have developed flexible, active, and multiplexed recording devices for high resolution recording over large, clinically relevant areas in the brain. While this technology has enabled a much higher-resolution view of the electrical activity of the brain, the analytical methods to process, categorize, and respond to the huge volumes of seizure data produced by these devices have not yet been developed. In this paper, we proposed an unsupervised learning framework for spike analysis, which by itself reveals spike pattern...
September 2017: IEEE Transactions on Nanobioscience
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