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https://www.readbyqxmd.com/read/30551120/effects-of-early-enteral-bovine-colostrum-supplementation-on-intestinal-permeability-in-critically-ill-patients-a-randomized-double-blind-placebo-controlled-study
#1
Ghazaleh Eslamian, Seyed Hossein Ardehali, Ahmad-Reza Baghestani, Zahra Vahdat Shariatpanahi
OBJECTIVES: In this study we sought to investigate the effect of early enteral bovine colostrum supplementation on intestinal permeability in intensive care unit (ICU)-hospitalized patients. METHODS: A total of 70 ICU-hospitalized adult patients were randomly assigned to receive a bovine colostrum supplement or placebo according to the stratified blocked randomization by age and admission category. Plasma endotoxin and zonulin concentrations were measured on days 5 and 10 of intervention...
October 12, 2018: Nutrition
https://www.readbyqxmd.com/read/30550995/an-improved-rat-model-for-chronic-inflammatory-bowel-disease
#2
Naga K R Ghattamaneni, Sunil K Panchal, Lindsay Brown
BACKGROUND: Inflammatory bowel disease (IBD) is an important cause of chronic disability in humans. METHODS: We characterized a model of chronic IBD in young male Wistar rats by administering dextran sodium sulfate (DSS: 0%, 0.25%, 0.5%, or 1% in drinking water) for six weeks, with 0.5% DSS for twelve weeks, following DSS cessation or together with treatment with sulfasalazine for the last 6 weeks. We measured gastrointestinal characteristics including stool consistency, blood in stools, small intestine and colon length, intestinal transit and permeability, and gut microbiota, as well as extra-intestinal parameters including oral glucose tolerance, systolic blood pressure, fat and lean mass, and left ventricular stiffness...
October 11, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/30550807/increasing-prevalence-of-the-epidemic-ribotype-106-in-healthcare-facility-associated-and-community-associated-clostridioides-difficile-infection
#3
Loreto Suárez-Bode, Rubén Barrón, José L Pérez, Ana Mena
Clostridioides difficile is the leading cause of nosocomial diarrhea and antibiotics associated diarrhea, but it is also an increasingly common cause of community diarrhea. In recent years we have observed a progressive increase in the incidence of C. difficile infection (CDI) both at the hospital and community setting that could be explained by the dynamic epidemiology of C. difficile. The present study analyzes changes in the epidemiology of CDI for two years comparing healthcare facility-associated (HCFA) and community- associated (CA) CDI epidemiology, observed in a single laboratory setting...
December 11, 2018: Anaerobe
https://www.readbyqxmd.com/read/30549162/enkephalinase-inhibitors-potential-therapeutics-for-the-future-treatment-of-diarrhea-predominant-functional-gastrointestinal-disorders
#4
REVIEW
Agata Szymaszkiewicz, Martin Storr, Jakub Fichna, Marta Zielinska
The endogenous opioid system (EOS) is considered being a crucial element involved in the pathophysiology of irritable bowel syndrome (IBS) as it regulates gastrointestinal (GI) homeostasis through modulation of motility and water and ion secretion/absorption. Along with opioid receptors (ORs), the following components of EOS can be distinguished: 1. endogenous opioid peptides (EOPs), namely enkephalins, endorphins, endomorphins and dynorphins, and 2. peptidases, which regulate the metabolism (synthesis and degradation) of EOPs...
December 14, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/30548242/clinical-practice-of-chinese-medicine-navel-therapy-for-chronic-diarrhea-a-literature-review
#5
REVIEW
Meng-Rui Chen, Jiang Zhao, Shu-Fei Fu, Jia-Qi Yu, Xuan Zhang, Qi-Yang Zhang, Zhi-Huan Zhou
Chronic diarrhea is one of the most common complaints in clinical practice for both adults and children. The purpose of this study was to assess the commonly used Chinese herbal medicine navel therapy for the treatment of chronic diarrhea (traditional Chinese medicine syndrome of spleen deficiency). The literature search was up to June 2018. Four types of studies (clinical trials, case series, case reports, and experts' experience) researched on Chinese medicine navel therapy used alone or combined with other therapies for the treatment of chronic diarrhea all included...
November 22, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30547953/systematic-review-of-nonpharmacologic-approaches-for-the-management-of-gastrointestinal-symptoms
#6
Catherine Cherwin, Lynn Nakad, Alaa Albashayreh
PROBLEM IDENTIFICATION: To summarize and critique the literature for nonpharmacologic complementary approaches to manage gastrointestinal (GI) symptoms attributed to chemotherapy. LITERATURE SEARCH: A literature search was conducted using CINAHL®, MEDLINE®, and PsycINFO® from database inception through January 2018. DATA EVALUATION: Studies were independently appraised by each author regarding inclusion eligibility and summary of GI symptom outcomes and the nonpharmacologic complementary intervention...
January 13, 2019: Oncology Nursing Forum
https://www.readbyqxmd.com/read/30547836/the-use-of-open-source-gis-algorithms-big-geographic-data-and-cluster-computing-techniques-to-compile-a-geospatial-database-that-can-be-used-to-evaluate-upstream-bathing-and-sanitation-behaviours-on-downstream-health-outcomes-in-indonesia-2000-2008
#7
Stuart E Hamilton, John Talbot, Carl Flint
BACKGROUND: Waterborne diseases are one of the leading causes of mortality in developing countries, and diarrhea alone is responsible for over 1.5 million deaths annually. Such waterborne illnesses most often affect those in impoverished rural communities who rely on rivers for their supply of drinking water. Deaths are most common among infants and the elderly. Without knowledge of which communities are upstream of a community, upstream sanitary and bathing behaviors can never be directly linked to downstream health outcomes including disease outbreaks...
December 14, 2018: International Journal of Health Geographics
https://www.readbyqxmd.com/read/30547675/gastrointestinal-complications-in-patients-treated-with-ipilimumab-and-nivolumab-combination-therapy-or-monotherapy
#8
Debra E Irwin, Brian Davis, Jill A Bell, Aaron Galaznik, Ignacio Garcia-Ribas
Aim & methods: A retrospective study using the IBM Explorys Universe Database assessed the risk of gastrointestinal events (enterocolitis or diarrhea) among melanoma and lung cancer patients treated with ipilimumab and nivolumab combination or monotherapy. Results & conclusion: There were 904 melanoma patients (607 ipilimumab, 140 nivolumab and 157 combo) and 1641 lung cancer patients (68 ipilimumab, 1542 nivolumab and 31 combo). Approximately, 37% of lung patients and 46% of melanoma patients experienced at least one adverse event...
December 14, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30547662/-role-of-prebiotics-and-probiotics-in-the-functionality-of-the-microbiota-in-the-patients-receiving-enteral-nutrition
#9
María D Ballesteros Pomar, Elena González Arnaiz
Set of resident microorganisms in our body that are responsible for the absorption of nutrients and the maintenance of health is named microbiota. The microbiota´s role is protective, trophic and metabolic. Different groups of microbiota intestinal name enterotypes, each one of them are in relation to specific dietary habits. The absence of enteral stimulation affects both epithelial and GALT and the development of the microbiota. This situation modifies the immune system´s interaction, with a less competitive exclusion of more pathogenic bacteria, which can promote infections...
April 3, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/30547058/risk-factors-for-short-and-long-term-outcomes-in-children-with-stec-hus-d-hus-a-single-center-experience
#10
Judith Sebestyen VanSickle, Tarak Srivastava, Uri S Alon
Background . Hemolytic uremic syndrome (HUS) is one of the common causes for acute kidney injury in childhood. Objective . The goals of our study were to identify risk factors for short-term complications and long-term outcomes of chronic kidney disease (CKD) in Shiga toxin-producing Escherichia coli (STEC)-HUS and other diarrhea positive (D+ ) HUS. Methods . Retrospective chart review was obtained of 58 pediatric patients treated for STEC-HUS and other D+ HUS between February 2002 and January 2011. Results ...
2018: Global Pediatric Health
https://www.readbyqxmd.com/read/30546886/radiotherapy-associated-intra-abdominal-angiosarcoma-after-prostatic-adenocarcinoma-case-reports
#11
David Parada Domínguez, Karla B Peña Gonzalez
Angiosarcoma is a rare soft tissue neoplasm, which accounts for <1% of all soft tissue tumours. It has been previously reported that the incidence rate of angiosarcomas increases following radiotherapy. The present study reports two cases of intra-abdominal angiosarcoma associated with previous radiotherapy treatment. To the best of our knowledge, these associations have not been previously described in English literature. The patients aged 71 and 83 years were admitted to the center for abdominal pain and diarrhea...
December 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30546870/effect-of-enhanced-detailing-and-mass-media-on-community-use-of-oral-rehydration-salts-and-zinc-during-a-scale-up-program-in-gujarat-and-uttar-pradesh
#12
Felix Lam, George Pro, Shreya Agrawal, Vishal Dev Shastri, Leslie Wentworth, Melinda Stanley, Nitin Beri, Abhishek Tupe, Ashutosh Mishra, Hamsa Subramaniam, Kate Schroder, Marta Rose Prescott, Naresh Trikha
Background: The Clinton Health Access Initiative implemented a program from 2012-2016 to increase use of oral rehydration salts (ORS) and zinc to treat diarrhea in children under five in three states in India: Gujarat, Madhya Pradesh, and Uttar Pradesh. The program interventions included detailing and development of a rural supply chain to reach private rural health care providers, training of Accredited Social Health Activists (ASHAs), technical support to the state governments, and a mass media campaign targeted at caregivers...
June 2019: Journal of Global Health
https://www.readbyqxmd.com/read/30546392/human-umbilical-cord-derived-mesenchymal-stem-cells-ameliorate-the-enteropathy-of-food-allergies-in-mice
#13
Nannan Yan, Jie Xu, Chuanxiang Zhao, Yi Wu, Fengwei Gao, Ci Li, Wenhui Zhou, Tengfei Xiao, Xiaoming Zhou, Qixiang Shao, Sheng Xia
Food allergy prevalence has steadily increased worldwide over the past decades and immunotherapeutic treatment strategies are gaining attention. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) exhibit similar immune regulatory properties to bone marrow-derived MSCs. hUC-MCSs can be prepared with fewer ethical constraints and are potential candidates for allergic disorder therapies. The current study aimed to investigate potential antiallergic properties of hUC-MSCs in mice with ovalbumin (OVA)-induced food allergy...
December 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30545363/transcriptomic-analysis-reveals-that-enterovirus-f-strain-swun-ab001-infection-activates-jnk-sapk-and-p38-mapk-signaling-pathways-in-mdbk-cells
#14
Bin Zhang, Xinnuo Chen, Hua Yue, Wenqiang Ruan, Sinan Qin, Cheng Tang
BACKGROUND: Enteroviruses (Picornaviridae family) have been widely detected in the feces from cattle with diarrhea. However, the mechanisms responsible for the pathogenicity of enteroviruses in cattle remain unclear. Recently, we isolated a novel EV-F7 strain called SWUN-AB001 from diarrheal yak (Bos grunniens) feces. To explore the pathogenic mechanisms of this novel virus, we used a transcriptomics approach to find genes with differential expression patterns in Madin-Darby bovine kidney (MDBK) cells during infection with SWUN-AB001 over time...
December 13, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/30545232/-role-of-prebiotics-and-probiotics-in-the-functionality-of-the-microbiota-in-the-patients-receiving-enteral-nutrition
#15
María D Ballesteros Pomar, Elena González Arnaiz
Set of resident microorganisms in our body that are responsible for the absorption of nutrients and the maintenance of health is named microbiota. The microbiota´s role is protective, trophic and metabolic. Different groups of microbiota intestinal name enterotypes, each one of them are in relation to specific dietary habits. The absence of enteral stimulation affects both epithelial and GALT and the development of the microbiota. This situation modifies the immune system´s interaction, with a less competitive exclusion of more pathogenic bacteria, which can promote infections...
April 3, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/30545071/experience-and-future-perceived-risk-of-floods-and-diarrheal-disease-in-urban-poor-communities-in-accra-ghana
#16
Mumuni Abu, Samuel Nii Ardey Codjoe
Diarrheal disease is a critical health condition in urban areas of developing countries due to increasing urbanization and its associated problems of sanitation and poor access to good drinking water. Increasing floods in cities have been linked to the risk of diarrheal disease. There are few studies that specifically link flooding with diarrhea diseases. This may be due to the fact that secondary data mainly hospital recorded cases, and not individual cases at the household level are used. Furthermore, of the few papers that consider the flood-diarrheal diseases nexus, none have considered risk perceptions in general, and more specifically, whether households that have experienced floods which resulted in a reported case of diarrhea, have higher perceived risks of future occurrences of the two phenomena compared to households that had different experiences...
December 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30545061/a-strategy-to-replace-the-mouse-bioassay-for-detecting-and-identifying-lipophilic-marine-biotoxins-by-combining-the-neuro-2a-bioassay-and-lc-ms-ms-analysis
#17
Marcia Bodero, Arjen Gerssen, Liza Portier, Mirjam D Klijnstra, Ron L A P Hoogenboom, Leonardo Guzmán, Peter J M Hendriksen, Toine F H Bovee
Marine biotoxins in fish and shellfish can cause several symptoms in consumers, such as diarrhea, amnesia, or even death by paralysis. Monitoring programs are in place for testing shellfish on a regular basis. In some countries testing is performed using the so-called mouse bioassay, an assay that faces ethical concerns not only because of animal distress, but also because it lacks specificity and results in high amounts of false positives. In Europe, for lipophilic marine biotoxins (LMBs), a chemical analytical method using LC-MS/MS was developed as an alternative and is now the reference method...
December 12, 2018: Marine Drugs
https://www.readbyqxmd.com/read/30544474/pressure-management-as-an-occupational-stress-risk-factor-in-irritable-bowel-syndrome-a-cross-sectional-study
#18
Stefan Lucian Popa, Daniel Corneliu Leucuta, Dan Lucian Dumitrascu
Irritable Bowel Syndrome (IBS) is the most prevalent functional gastrointestinal disorder. Psychosocial stress is one of the pathogenic factors involved in the pathogenesis of IBS. The Pressure Management Indicator (PMI) is a validated questionnaire to analyze all aspects of occupational stress-a model involving sources of pressure, the mechanisms of coping, the personality, and the resulting effects of the interaction between these 3 elements. The purpose of this study was to analyze the association between socio-professional stress effects in IBS, and the relationship of IL-6 levels and salivary cortisol with occupational stress...
December 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30543777/a-microbiota-derived-bacteriocin-targets-the-host-to-confer-diarrhea-resistance-in-early-weaned-piglets
#19
Jun Hu, Libao Ma, Yangfan Nie, Jianwei Chen, Wenyong Zheng, Xinkai Wang, Chunlin Xie, Zilong Zheng, Zhichang Wang, Tao Yang, Min Shi, Lingli Chen, Qiliang Hou, Yaorong Niu, Xiaofan Xu, Yuhua Zhu, Yong Zhang, Hong Wei, Xianghua Yan
Alternatives to antibiotics for preventing diarrhea in early-weaned farm animals are sorely needed. CM piglets (a native Chinese breed) are more resistant to early-weaning stress-induced diarrhea than the commercial crossbred LY piglets. Transferring fecal microbiota, but not saline, from healthy CM into LY piglets by oral administration prior to early weaning conferred diarrhea resistance. By comparing the relative abundance of intestinal microbiota in saline and microbiota transferred LY piglets, we identified and validated Lactobacillus gasseri LA39 and Lactobacillus frumenti as two bacterial species that mediate diarrhea resistance...
December 12, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/30543759/relationship-among-breastfeeding-exposure-knowledge-and-attitudes-in-collegiate-males-residing-in-east-texas
#20
Leslie Heathman, Crystal Clark Douglas, Simone P Camel
BACKGROUND: Researchers exploring breastfeeding attitudes and knowledge among women suggest the decision to breastfeed is influenced by the male partner, yet few studies address males. Because collegiate males will soon enter fatherhood, assessment of their attitudes and knowledge may inform interventions aimed at increasing intention to breastfeed. RESEARCH AIM: This study aimed to describe collegiate males' exposure to, attitude toward, and knowledge about breastfeeding...
December 13, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
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