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Michelle A O Kinney, David M Nagorney, Daniel F Clark, Travis D O'Brien, Jonathan D Turner, Mary E Marienau, Darrell R Schroeder, David P Martin
STUDY OBJECTIVE: Partial hepatic resection reduces tumor burden in patients with metastatic neuroendocrine tumors, thereby improving quality and length of life. These procedures can be challenging as well as life-threatening. Our aim was to evaluate our patients' perioperative outcomes and propose a definition for an intraoperative carcinoid crisis relevant to this surgery, given its unique surgical considerations. DESIGN: Retrospective study. SETTING: Mayo Clinic, Rochester, Minnesota...
August 8, 2018: Journal of Clinical Anesthesia
Pierre Champigneux, Marie-Line Delia, Alain Bergel
From a fundamental standpoint, microbial electrochemistry is unravelling a thrilling link between life and materials. Technically, it may be the source of a large number of new processes such as microbial fuel cells for powering remote sensors, autonomous sensors, microbial electrolysers and equipment for effluent treatment. Microbial electron transfers are also involved in many natural processes such as biocorrosion. In this context, a huge number of studies have dealt with the impact of electrode materials, coatings and surface functionalizations but very few have focused on the effect of the surface topography, although it has often been pointed out as a key parameter impacting the performance of electroactive biofilms...
July 11, 2018: Biosensors & Bioelectronics
Michael De Pretto, Marie-Pierre Deiber, Clara E James
Sensorimotor synchronization (SMS) requires aligning motor actions to external events and represents a core part of both musical and dance performances. In the current study, to isolate the brain mechanisms involved in synchronizing finger tapping with a musical beat, we compared SMS to pure self-paced finger tapping and listen-only conditions at different tempi. We analyzed EEG data using frequency domain steady-state evoked potentials (SSEPs) to identify sustained electrophysiological brain activity during repetitive tasks...
August 8, 2018: Human Movement Science
Mauro Santibanez Koref, Helen Griffin, Douglass M Turnbull, Patrick F Chinnery, Mary Herbert, Gavin Hudson
The mitochondrial genome has recently become the focus of several high-impact next-generation sequencing studies investigating the effect of mutations in disease and assessing the efficacy of mitochondrial replacement therapies. However, these studies have failed to take into consideration the capture of recurring translocations of mitochondrial DNA to the nuclear genome, known as nuclear mitochondrial sequences (NUMTs), continuing to align sequence data to the revised Cambridge reference sequence alone. Here, using different mtDNA enrichment techniques and a variety of tissues, we demonstrate that NUMTs are present in sequence data and that, dependent upon downstream analysis, are at a level which affects variant calling...
August 8, 2018: Mitochondrion
Jessica Liang, Stephanie J Lee, Barry E Storer, Bronwen E Shaw, Eric J Chow, Mary E Flowers, Elizabeth F Krakow, Merav Bar, Karen L Syrjala, Rachel B Salit, Chareeni E Kurukulasuriya, Heather S L Jim
BACKGROUND: Hematopoietic cell transplant (HCT) can cause significant distress in patients and their informal caregivers. Despite advances in reduced intensity conditioning and supportive care, few recent studies have reported rates of clinically-significant post-traumatic stress disorder symptomatology (hereafter referred to as PTSD). Goals of the current study were to: 1) examine rates of PTSD and distress in patients and caregivers and 2) identify sociodemographic and clinical risk factors for PTSD...
August 8, 2018: Biology of Blood and Marrow Transplantation
Michael G Watson, Helen M Byrne, Charlie Macaskill, Mary R Myerscough
Atherosclerotic plaque growth is characterised by chronic, non-resolving inflammation that promotes the accumulation of cellular debris and extracellular fat in the inner artery wall. This material is highly thrombogenic, and plaque rupture can lead to the formation of blood clots that occlude major arteries and cause myocardial infarction or stroke. In advanced plaques, vascular smooth muscle cells (SMCs) are recruited from deeper in the artery wall to synthesise a cap of fibrous tissue that stabilises the plaque and sequesters the thrombogenic plaque content from the bloodstream...
August 8, 2018: Journal of Theoretical Biology
Charlotte J Green, Siôn A Parry, Pippa J Gunn, Carlo D L Ceresa, Fredrik Rosqvist, Marie-Eve Piché, Leanne Hodson
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing. Determining the pathogenesis and pathophysiology of human NAFLD will allow for evidence-based prevention strategies, and more targeted mechanistic investigations. Various in vivo, ex situ and in vitro models may be utilised to study NAFLD; but all come with their own specific caveats. Here, we review the human-based models and discuss their advantages and limitations in regards to studying the development and progression of NAFLD. Overall, in vivo whole-body human studies are advantageous in that they allow for investigation within the physiological setting, however, limited accessibility to the liver makes direct investigations challenging...
August 11, 2018: Hormone Molecular Biology and Clinical Investigation
Gary Winship, Ben Hannigan, Sally Hardy, Joy Bray, Mary Chambers
Eileen Skellern's contribution to the development of the modern profession of psychiatric and mental health nursing in the UK was considerable both in terms of practice and policy development. Skellern organised the first major international mental health nursing conference in the UK in 1980, but sadly she died two months before the conference. In 1982 the Skellern Lecture was established to remember Eileen. Since then, there has been a long list of leading nurses who have delivered the Skellern Lecture. This article is protected by copyright...
August 11, 2018: Journal of Psychiatric and Mental Health Nursing
Ora Paltiel, Stanley Lemeshow, Gary S Phillips, Gabriella Tikellis, Martha S Linet, Anne-Louise Ponsonby, Per Magnus, Siri E Håberg, Sjurdur F Olsen, Charlotta Granström, Mark Klebanoff, Jean Golding, Zdenko Herceg, Akram Ghantous, Jane Elizabeth Hirst, Arndt Borkhardt, Mary H Ward, Signe Holst Søegaard, Terence Dwyer
The "delayed infection hypothesis" states that a paucity of infections in early childhood may lead to higher risks of childhood leukemia (CL), especially acute lymphoblastic leukemia (ALL). Using prospectively collected data from six population-based birth cohorts we studied the association between birth order (a proxy for pathogen exposure) and CL. We explored whether other birth or parental characteristics modify this association. With 2.2X106 person-years of follow-up, 185 CL and 136 ALL cases were ascertained...
August 11, 2018: International Journal of Cancer. Journal International du Cancer
Sherin Shaaban, Sarah MacKinnon, Caroline Andrews, Sandra E Staffieri, Gail D E Maconachie, Wai-Man Chan, Mary C Whitman, Sarah U Morton, Seyhan Yazar, Stuart MacGregor, James E Elder, Elias I Traboulsi, Irene Gottlob, Alex W Hewitt, David G Hunter, David A Mackey, Elizabeth C Engle
Purpose: To identify genetic variants conferring susceptibility to esotropia. Esotropia is the most common form of comitant strabismus, has its highest incidence in European ancestry populations, and is believed to be inherited as a complex trait. Methods: White European American discovery cohorts with nonaccommodative (826 cases and 2991 controls) or accommodative (224 cases and 749 controls) esotropia were investigated. White European Australian and United Kingdom cohorts with nonaccommodative (689 cases and 1448 controls) or accommodative (66 cases and 264 controls) esotropia were tested for replication...
August 1, 2018: Investigative Ophthalmology & Visual Science
Paul A Wetzel, Anne S Lindblad, Hardik Raizada, Nathan James, Caroline Mulatya, Mary A Kannan, Zoe Villamar, George T Gitchel, Lindell K Weaver
Purpose: Standard physical, neurologic, and neuropsychologic examinations may not detect abnormalities after mild traumatic brain injury (mTBI). An analysis of eye movements may be more sensitive to neurologic dysfunction. Methods: We performed eye tracking assessments in 71 active duty and veteran military personnel with persistent postconcussive symptoms (3 months to 5 years after mTBI) and 75 volunteers with no history of brain injury. Both eyes were sampled at 500 Hz and analyzed for various eye measurement parameters during visual tasks involving the saccadic and smooth systems...
August 1, 2018: Investigative Ophthalmology & Visual Science
Henny-Kristine Korsmo-Haugen, Kjetil Gundro Brurberg, Jim Mann, Anne-Marie Aas
AIMS: This systematic review and meta-analysis compares the effects of low carbohydrate diets (LCDs) on body weight, glycaemic control, lipid profile and blood pressure with those observed on higher carbohydrate diets (HCDs) in adults with type 2 diabetes. METHODS: MEDLINE, EMBASE, CENTRAL, CINAHL, Food Science Source and SweMed+ databases were systematically searched to identify randomised controlled trials (duration ≥ 3 months) investigating the effects of a LCD compared to a HCD in the management of type 2 diabetes...
August 11, 2018: Diabetes, Obesity & Metabolism
Kalina Rajaobelina, Courtney Dow, Francesca Romana Mancini, Laureen Dartois, Marie-Christine Boutron-Ruault, Beverley Balkau, Fabrice Bonnet, Guy Fagherazzi
BACKGROUND: Though many type 2 diabetes (T2D) risk factors have been identified, little is known on their contributions to the diabetes burden at the population level. METHODS: The study included, 72 655 French women from the E3N prospective cohort followed between 1993 and 2011. We used Cox multivariable models including the main T2D risk factors (metabolic, dietary, clinical, socio-economic and hormonal), as well as a healthy lifestyle index combining five characteristics (smoking, body mass index (BMI), alcohol consumption, fruit and vegetable consumption and physical activity) to estimate hazard ratios and population attributable fractions (PAFs) for T2D...
August 11, 2018: Journal of Diabetes
Markus Ruhnke, Gerhard Behre, Dieter Buchheidt, Maximilian Christopeit, Axel Hamprecht, Werner Heinz, Claus-Peter Heussel, Marius Horger, Oliver Kurzai, Meinolf Karthaus, Jürgen Löffler, Georg Maschmeyer, Olaf Penack, Christina Rieger, Volker Rickerts, Jörg Ritter, Martin Schmidt-Hieber, Nikolai Schuelper, Stefan Schwartz, Andrew Ullmann, Jörg-Janne Vehreschild, Marie von Lilienfeld-Toal, Thomas Weber, Hans-H Wolf
Invasive fungal diseases (IFD) are a primary cause of morbidity and mortality in patients with haematological malignancies. These infections are mostly life-threatening and an early diagnosis and initiation of appropriate antifungal therapy are essential for the clinical outcome. Most commonly, Aspergillus and Candida species are involved. However, other Non-Aspergillus moulds are increasingly identified in case of documented IFD. For definite diagnosis of IFD, a combination of diagnostic tools have to be applied, including conventional mycological culture and non-conventional microbiological tests such as antibody / antigen and molecular tests, as well as histopathology and radiology...
August 11, 2018: Mycoses
Bouchra Habib Geryes, Lama Hadid-Beurrier, Marie-Joséphine Waryn, Antonella Jean-Pierre, Jad Farah
PURPOSE: To perform a benchmark of a new DACS-integrated patient skin dose mapping solution using on-phantom measurements with Gafchromic® films. MATERIALS AND METHODS: To calculate cumulative patient skin dose distribution with 1 cm² resolution, Radiation Dose Monitor (RDM, Medsquare) uses the Radiation Dose Structured Report (RDSR), tabulated backscatter and mass energy absorption coefficients together with site-specific corrections for table, mattress attenuation and air-kerma calibration factor...
August 11, 2018: Medical Physics
Surbhi Desai, Boguslawa R Dworecki, Marie C Nlend
Western blotting is one of the few basic techniques widely used in the study of proteins in life science research. Despite its prevalence, the procedure has remained practically unchanged for more than 20 years. Although the method is viewed as being error-prone and as requiring excessive hands-on time, it is still widely accepted because it provides sensitive and direct information about the protein characteristics. The process is attractive to researchers because it reduces the investment in instrumentation and set up...
2018: Methods in Molecular Biology
Émilie Proulx, Audrey Auclair, Marie-Eve Piché, Jany Harvey, Myriam Pettigrew, Laurent Biertho, Simon Marceau, Paul Poirier
INTRODUCTION: Safety of exercise training in relationship with the risk of hypoglycemia post-bariatric surgery is unknown. OBJECTIVE: To evaluate the safety and magnitude of changes in blood glucose levels during exercise training following bariatric surgery. MATERIAL AND METHODS: Twenty-nine severely obese patients undergoing either sleeve gastrectomy (SG) (n = 16) or biliopancreatic diversion with duodenal switch (BPD-DS) (n = 13) were prospectively enrolled...
August 10, 2018: Obesity Surgery
Laura Elenor Forrest, Sarah Dilys Sawyer, Nina Hallowell, Paul Andrew James, Mary-Anne Young
Evidence is accumulating of the clinical utility of single nucleotide polymorphisms to effectively stratify risk of breast cancer. Yet for this personalized polygenic information to be translated to clinical practice, consideration is needed about how this personalized risk information should be communicated and the impact on risk perception. This study examined the psychosocial implications and the impact on risk perception of communicating personalized polygenic breast cancer risk to high-risk women. High-risk women with a personal history of breast cancer and an uninformative BRCA1/2 result were genotyped in the Variants in Practice study for 22 breast cancer single nucleotide polymorphisms...
August 10, 2018: Journal of Community Genetics
A Albert-Marí, S Valero-García, V Fornés-Ferrer, J L Poveda-Andrés
Background Dose banding (DB) is a strategy to rationalise antineoplastic production at Hospital Pharmacy Aseptic Compounding Units (ACUs) and to reduce patient's waiting time. DB allows for optimizing workflows and workloads, facilitating adoption of new technologies, and increasing safety, quality and efficiency of the compounding process. Objective To evaluate the potential impact of implementation of Logarithmic DB and to identify antineoplastic agents and preparations that fulfil criteria published and establish the number and standard doses that could be compounded in advance at the ACU...
August 10, 2018: International Journal of Clinical Pharmacy
Jamie S Myers, Melike Kahya, Melissa Mitchell, Junqiang Dai, Jianghua He, Sanghee Moon, Kevin Hamilton, Mary Valla, Anne O'Dea, Jennifer Klemp, Monica Kurylo, Abiodun Akinwuntan, Hannes Devos
PURPOSE: The purpose of this cross-sectional comparative pilot study was to evaluate cognitive effort, indexed by pupillary response (PR), for breast cancer survivors (BCS) with complaints of cognitive dysfunction following chemotherapy. STUDY AIMS: Compare the cognitive effort employed by BCS to healthy controls (HC) during neuropsychological tests (NPT) for memory, sustained attention, verbal fluency, visuospatial ability, processing speed and executive function; and Investigate the relationship between PR-indexed cognitive effort and participants' self-report of cognitive function...
August 10, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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