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https://www.readbyqxmd.com/read/30334165/incidence-and-predictors-of-prolonged-postoperative-ileus-after-colorectal-surgery-in-the-context-of-an-enhanced-recovery-pathway
#1
Mohsen Alhashemi, Julio F Fiore, Nadia Safa, Mohammed Al Mahroos, Juan Mata, Nicolò Pecorelli, Gabriele Baldini, Nandini Dendukuri, Barry L Stein, A Sender Liberman, Patrick Charlebois, Franco Carli, Liane S Feldman
BACKGROUND: Prolonged postoperative ileus (PPOI) is common after colorectal surgery but has not been widely studied in the context of enhanced recovery pathways (ERPs) that include interventions aimed to accelerate gastrointestinal recovery. The aim of this study is to estimate the incidence and predictors of PPOI in the context of an ERP for colorectal surgery. METHODS: We analyzed data from an institutional colorectal surgery ERP registry. Incidence of PPOI was estimated according to a definition adapted from Vather (intolerance of solid food and absence of flatus or bowel movement for ≥ 4 days) and compared to other definitions in the literature...
October 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30321631/report-from-the-killer-cell-immunoglobulin-like-receptors-kir-component-of-the-17th-international-hla-and-immunogenetics-workshop
#2
REVIEW
Maneesh K Misra, Danillo G Augusto, Gonzalo Montero Martin, Neda Nemat-Gorgani, Jürgen Sauter, Jan A Hofmann, James A Traherne, Betsy González-Quezada, Clara Gorodezky, Will P Bultitude, Wesley Marin, Cynthia Vierra-Green, Kirsten M Anderson, Antonio Balas, Jose L Caro-Oleas, Elisa Cisneros, Francesco Colucci, Ravi Dandekar, Sally M Elfishawi, Marcelo A Fernández-Viña, Merhan Fouda, Rafael González-Fernández, Arend Große, Maria J Herrero-Mata, Sam Q Hollenbach, Steven G E Marsh, Alex Mentzer, Derek Middleton, Ashley Moffett, Miguel A Moreno-Hidalgo, Ghada I Mossallam, Annettee Nakimuli, Jorge R Oksenberg, Stephen J Oppenheimer, Peter Parham, Maria-Luiza Petzl-Erler, Dolores Planelles, Florentino Sánchez-García, Francisco Sánchez-Gordo, Alexander H Schmidt, John Trowsdale, Luciana B Vargas, Jose L Vicario, Carlos Vilches, Paul J Norman, Jill A Hollenbach
The goals of the KIR component of the 17th International HLA and Immunogenetics Workshop (IHIW) were to encourage and educate researchers to begin analyzing KIR at allelic resolution, and to survey the nature and extent of KIR allelic diversity across human populations. To represent worldwide diversity, we analyzed 1269 individuals from ten populations, focusing on the most polymorphic KIR genes, which express receptors having three immunoglobulin (Ig)-like domains (KIR3DL1/S1, KIR3DL2 and KIR3DL3). We identified 13 novel alleles of KIR3DL1/S1, 13 of KIR3DL2 and 18 of KIR3DL3...
October 12, 2018: Human Immunology
https://www.readbyqxmd.com/read/30290232/microsatellite-based-genetic-diversity-of-dermacentor-reticulatus-in-europe
#3
Algimantas Paulauskas, Matas Galdikas, Eglė Galdikaitė-Brazienė, Michal Stanko, Olaf Kahl, Grzegorz Karbowiak, Jana Radzijevskaja
Dermacentor reticulatus, also known as ornate dog tick, is an important vector of the causative agents of various tick-borne diseases in humans, livestock and wild animals. The geographical range of D. reticulatus in Europe is fragmented and divided into two main zones: The Western European and the Eastern European zone. To investigate D. reticulatus population structure through its distribution range we used microsatellite markers and compared the genetic diversity of D. reticulatus in 26 selected sites in the western and eastern European distribution areas...
October 2, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/30261412/predictors-of-cognitive-performance-in-bipolar-disorder-the-role-of-educational-degree-and-inflammatory-markers
#4
Izabela Guimarães Barbosa, Rodrigo de Almeida Ferreira, Natalia Pessoa Rocha, Giovana Carvalho Mol, Flavia da Mata Chiaccjio Leite, Isabelle E Bauer, Antonio L Teixeira
BACKGROUND: The aim of this article was to evaluate the cognitive status of remitted patients with bipolar disorder (BD) using Mini-Mental State Examination (MMSE), Frontal Assessment Battery, and Brief Assessment of Cognition in Affective Disorders (BAC-A). The BAC-A is a comprehensive test battery addressing the cognitive domains compromised in BD. We also aimed to analyze potential clinical and immune predictors of cognitive performance in BD. METHODS: Remitted patients with BD (M ± S...
September 17, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/30251309/a-qualitative-inquiry-of-old-people-s-health-literacy-in-situations-of-health-uncertainty
#5
Hadas Matas, Jenny Bronstein
BACKGROUND: This paper examines the health literacy of seniors and the strategies they use to deal with health uncertainty in the context of changes in the health system in Israel that have created a need to examine health literacy in this sector of the population who use the health system the most. The oldest were born and grew up in an era when a physician's knowledge was unchallenged; now, they find it difficult to cope with the expectation of patients taking a role in decision making...
September 24, 2018: Health Information and Libraries Journal
https://www.readbyqxmd.com/read/30245618/moubeat-a-new-and-open-toolbox-for-guided-analysis-of-behavioral-tests-in-mice
#6
Elísabet Bello-Arroyo, Hélio Roque, Alberto Marcos, Javier Orihuel, Alejandro Higuera-Matas, Manuel Desco, Valeria R Caiolfa, Emilio Ambrosio, Enrique Lara-Pezzi, María Victoria Gómez-Gaviro
Animal behavioral tests are essential to understand the bases of neurologic and psychological disorders, which can be evaluated by different methodological and experimental models. However, the quantification of behavioral tests results is limited by the considerable amount of time needed for manual evaluation and the high costs of automated analysis software. To overcome these limitations, we describe here a new, open source toolbox for ImageJ, called Mouse Behavioral Analysis Toolbox (MouBeAT), designed to analyze different behavioral tests in rodents semi-automatically...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/30215167/automated-neuron-detection-in-high-content-fluorescence-microscopy-images-using-machine-learning
#7
Gadea Mata, Miroslav Radojević, Carlos Fernandez-Lozano, Ihor Smal, Niels Werij, Miguel Morales, Erik Meijering, Julio Rubio
The study of neuronal morphology in relation to function, and the development of effective medicines to positively impact this relationship in patients suffering from neurodegenerative diseases, increasingly involves image-based high-content screening and analysis. The first critical step toward fully automated high-content image analyses in such studies is to detect all neuronal cells and distinguish them from possible non-neuronal cells or artifacts in the images. Here we investigate the performance of well-established machine learning techniques for this purpose...
September 13, 2018: Neuroinformatics
https://www.readbyqxmd.com/read/30195531/profiling-of-bacterial-and-fungal-communities-of-mexican-cheeses-by-high-throughput-dna-sequencing
#8
Selvasankar Murugesan, Maria Paulina Reyes-Mata, Khemlal Nirmalkar, Alejandra Chavez-Carbajal, Josue Isaac Juárez-Hernández, Rosario Erea Torres-Gómez, Alberto Piña-Escobedo, Otoniel Maya, Carlos Hoyo-Vadillo, Emma Gloria Ramos-Ramírez, Juan Alfredo Salazar-Montoya, Jaime García-Mena
Cheese is a live food whose preparation involves procedures and microbial communities playing an important role for the final product. We characterized the bacterial and fungal diversity of seventeen different Mexican cheeses by high-throughput DNA sequencing of 16S/18S rDNA libraries. We propose the existence of bacterial and fungal core communities, where at genera level, bacteria include Streptococcus spp., Lactococcus spp., Lactobacillus spp., Aerococcus spp., and Weisella spp. while at species level, the fungal community includes Galactomyces reessii, Scheffersomyces stipitis, Saccharomyces cerevisiae (baker's yeast), and S...
November 2018: Food Research International
https://www.readbyqxmd.com/read/30195415/convolutional-neural-networks-with-template-based-data-augmentation-for-functional-lung-image-quantification
#9
Nicholas J Tustison, Brian B Avants, Zixuan Lin, Xue Feng, Nicholas Cullen, Jaime F Mata, Lucia Flors, James C Gee, Talissa A Altes, John P Mugler Iii, Kun Qing
RATIONALE AND OBJECTIVES: We propose an automated segmentation pipeline based on deep learning for proton lung MRI segmentation and ventilation-based quantification which improves on our previously reported methodologies in terms of computational efficiency while demonstrating accuracy and robustness. The large data requirement for the proposed framework is made possible by a novel template-based data augmentation strategy. Supporting this work is the open-source ANTsRNet-a growing repository of well-known deep learning architectures first introduced here...
September 5, 2018: Academic Radiology
https://www.readbyqxmd.com/read/30151948/incidence-and-magnitude-of-post-transplant-cardiovascular-disease-after-pediatric-kidney-transplantation-risk-factor-analysis-of-1058-pediatric-kidney-transplants-at-the-university-of-minnesota
#10
Oscar K Serrano, Ananta S Bangdiwala, David M Vock, Srinath Chinnakotla, Ty B Dunn, Erik B Finger, Raja Kandaswamy, Timothy L Pruett, John S Najarian, Arthur J Matas, Blanche Chavers
BACKGROUND: KT recipients have increased the risk of CVD. The incidence of post-transplant CVEs among pediatric recipients has not been well-characterized. PATIENTS AND METHODS: Between 1963 and 2015, 884 pediatric (age: 0-17 years old) recipients received 1058 KTs at our institution. The cumulative incidence of CVEs was analyzed. Statistical models were used to estimate risk factors for developing post-transplant CVEs. RESULTS: Overall median patient survival was 33 years (IQR: 18...
August 27, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/30149934/implications-of-excess-weight-on-kidney-donation-long-term-consequences-of-donor-nephrectomy-in-obese-donors
#11
Oscar K Serrano, Bodhisatwa Sengupta, Ananta Bangdiwala, David M Vock, Ty B Dunn, Erik B Finger, Timothy L Pruett, Arthur J Matas, Raja Kandaswamy
BACKGROUND: An elevated body mass index (>30 kg/m2 ) has been a relative contraindication for living kidney donation; however, such donors have become more common. Given the association between obesity and development of diabetes, hypertension, and end-stage renal disease, there is concern about the long-term health of obese donors. METHODS: Donor and recipient demographics, intraoperative parameters, complications, and short- and long-term outcomes were compared between contemporaneous donors-obese donors (body mass index ≥30 kg/m2 ) versus nonobese donors (body mass index <30 kg/m2 )...
August 24, 2018: Surgery
https://www.readbyqxmd.com/read/30137126/drug-utilization-and-factors-associated-with-polypharmacy-in-individuals-with-diabetes-mellitus-in-minas-gerais-brazil
#12
Michael Ruberson Ribeiro da Silva, Leonardo Maurício Diniz, Jéssica Barreto Ribeiro Dos Santos, Edna Afonso Reis, Adriana Rodrigues da Mata, Vânia Eloisa de Araújo, Juliana Álvares, Francisco de Assis Acurcio
The objective of this study was to evaluate the use of drugs and the factors associated with polypharmacy in patients with diabetes mellitus (DM) in Minas Gerais. Descriptive analysis of drugs in use and logistic regression to estimate the association between socio-demographic and clinical characteristics with polypharmacy were performed. Of the 2619 respondents, 56.5% were in polypharmacy. Drugs for DM, agent in renin-angiotensin system, and diuretics are the most frequently used. Factors such as age, comorbidities and increased access to health services were associated with polypharmacy...
August 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/30132282/study-on-the-accuracy-of-structural-and-fsi-heart-valves-simulations
#13
Giulia Luraghi, Francesco Migliavacca, Josè Fèlix Rodriguez Matas
PURPOSE: The performance of heart valves, either native or artificial, can be evaluated by means of finite element analyses, either from a structural or a fluid-structure interaction (FSI) point of view. The latter captures the coupling between the valve leaflets and the blood in a more realistic way. The selection of the appropriate finite elements approach for the model is the first and fundamental step to achieve accurate simulations. The aim of this work is to investigate the influence of the type, formulation, size, and shape of the elements in heart valves simulations...
August 21, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/30119441/intensity-based-adaptive-optics-with-sequential-optimization-for-laser-communications
#14
Carlos E Carrizo, Ramon Mata Calvo, Aniceto Belmonte
Wavefront distortions of optical waves propagating through the turbulent atmosphere are responsible for phase and amplitude fluctuations, causing random fading in the signal coupled into single-mode optical fibers. Wavefront aberrations can be confronted, in principle, with adaptive optics technology that compensates the incoming optical signal by the phase conjugation principle and mitigates the likeliness of fading. However, real-time adaptive optics requires phase wavefront measurements, which are generally difficult under typical propagation conditions for communication scenarios...
June 25, 2018: Optics Express
https://www.readbyqxmd.com/read/30109608/imaging-of-transcription-and-replication-in-the-bacterial-chromosome-with-multicolor-three-dimensional-superresolution-structured-illumination-microscopy
#15
Carmen Mata Martin, Cedric Cagliero, Zhe Sun, De Chen, Ding Jun Jin
Superresolution imaging technology has contributed to our understanding of the subnucleoid organization in E. coli cells. Multicolor superresolution images revealing "bacterial nucleolus-like structure or organization," "nucleolus-like compartmentalization of the transcription factories," and "spatial segregation of the transcription and replication machineries" have enhanced our understanding of the dynamic landscape of the bacterial chromatin. This chapter provides a brief introduction into multicolor three-dimensional superresolution structured illumination microscopy (3D-SIM) used to study the spatial organization of the transcription machinery and its spatial relationship with replisomes from a microbiological research perspective...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30098211/association-between-development-of-dementia-and-use-of-benzodiazepines-a-systematic-review-and-meta-analysis
#16
Rosa Camila Lucchetta, Barbara Paes Miglioli da Mata, Patricia de Carvalho Mastroianni
STUDY OBJECTIVE: The use of benzodiazepines and the development of dementia is controversial, with studies indicating that benzodiazepines could be either a protective factor or a risk factor for dementia, or no association may exist between the two. Our objective was to identify whether such an association exists. DESIGN: Systematic review and meta-analysis of 12 prospective and retrospective cohort studies and case-control studies. PARTICIPANTS: A total of 981,133 (in the systematic review) and 980,860 (in the meta-analysis) adults or elderly individuals...
August 11, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/30095057/microencapsulation-of-carvacrol-using-pectin-aloe-gel-as-a-novel-wound-dressing-films
#17
Gabriel Humberto Gomez-Rodriguez, Marco Antonio Lopez-Mata, Edith Valbuena-Gregorio, Ramon Gertrudis Valdez Melchor, Julio Cesar Campos-Garcia, Norma Patricia Silva-Beltran, Luis Quihui-Cota, Saul Ruiz-Cruz, Josue Juarez
Recently, pectin (PEC) and Aloe-gel (AG) have received great attention for their use in the encapsulation of hydrophobic bioactive compounds such as carvacrol (CAR). The aim of this study is to assess the physical, chemical and biological properties of a novel PEC/AG film and evaluate its capability to entrap CAR into microencapsulates. For this purpose, the casting method was used to prepare the PEC/AG membranes (70:30 % w/w). The CAR-loaded PEC/AG film were prepared adding different proportions of CAR (0...
August 10, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/30088931/all-that-binds-is-not-gold-the-relative-weight-of-aurophilic-interactions-in-complex-formation
#18
Axel Wuttke, Milica Feldt, Ricardo A Mata
Often have you heard that complexes containing close Au(I) contacts are strongly influenced by what has come to be known as aurophilic interactions. In this work, local orbital analysis is carried out to separate competing metallophilic and other weak interactions at the correlated level in three selected molecular crystals. We carefully separate and discuss the different contributions to the total interaction energy of dimers and trimers according to their spatial location, and identify the relative weight in binding...
August 30, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/30071997/clinical-genetic-testing-for-familial-hypercholesterolemia-jacc-scientific-expert-panel
#19
REVIEW
Amy C Sturm, Joshua W Knowles, Samuel S Gidding, Zahid S Ahmad, Catherine D Ahmed, Christie M Ballantyne, Seth J Baum, Mafalda Bourbon, Alain Carrié, Marina Cuchel, Sarah D de Ferranti, Joep C Defesche, Tomas Freiberger, Ray E Hershberger, G Kees Hovingh, Lala Karayan, Johannes Jacob Pieter Kastelein, Iris Kindt, Stacey R Lane, Sarah E Leigh, MacRae F Linton, Pedro Mata, William A Neal, Børge G Nordestgaard, Raul D Santos, Mariko Harada-Shiba, Eric J Sijbrands, Nathan O Stitziel, Shizuya Yamashita, Katherine A Wilemon, David H Ledbetter, Daniel J Rader
Although awareness of familial hypercholesterolemia (FH) is increasing, this common, potentially fatal, treatable condition remains underdiagnosed. Despite FH being a genetic disorder, genetic testing is rarely used. The Familial Hypercholesterolemia Foundation convened an international expert panel to assess the utility of FH genetic testing. The rationale includes the following: 1) facilitation of definitive diagnosis; 2) pathogenic variants indicate higher cardiovascular risk, which indicates the potential need for more aggressive lipid lowering; 3) increase in initiation of and adherence to therapy; and 4) cascade testing of at-risk relatives...
August 7, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/30058187/development-of-a-food-frequency-questionnaire-for-brazilian-athletes
#20
Allan da Mata Godois, Christianne de Faria Coelho-Ravagnani, Raquel Raizel, Eliseu Verly-Junior
AIM: Until recently most dietary survey methods have been developed for non-athletic populations. In this study, we aimed to develop a Food Frequency Questionnaire (FFQ) to assess the regular dietary intake of Brazilian athletes. METHODS: We interviewed 141 athletes (23.36 ± 7.77 years old) for their dietary intake using 24-hour recalls. After grouping conceptually similar food items into 113 food items, percentage contribution analysis and stepwise regression models were used to highlight foods contributing to at least 90% of the between-person variability of key nutrients...
July 29, 2018: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
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