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https://www.readbyqxmd.com/read/30109608/imaging-of-transcription-and-replication-in-the-bacterial-chromosome-with-multicolor-three-dimensional-superresolution-structured-illumination-microscopy
#1
Carmen Mata Martin, Cedric Cagliero, Zhe Sun, De Chen, Ding Jun Jin
Superresolution imaging technology has contributed to our understanding of the subnucleoid organization in E. coli cells. Multicolor superresolution images revealing "bacterial nucleolus-like structure or organization," "nucleolus-like compartmentalization of the transcription factories," and "spatial segregation of the transcription and replication machineries" have enhanced our understanding of the dynamic landscape of the bacterial chromatin. This chapter provides a brief introduction into multicolor three-dimensional superresolution structured illumination microscopy (3D-SIM) used to study the spatial organization of the transcription machinery and its spatial relationship with replisomes from a microbiological research perspective...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30098211/association-between-development-of-dementia-and-use-of-benzodiazepines-a-systematic-review-and-meta-analysis
#2
Rosa Camila Lucchetta, Barbara Paes Miglioli da Mata, Patricia Carvalho Mastroianni
STUDY OBJECTIVE: Divergent opinions exist on the use of benzodiazepines and the development of dementia, with studies indicating that benzodiazepines could be either a protective factor or a risk factor for dementia, or that there may be an absence of an association between the two. The objective of this study was to identify whether an association exists between the use of benzodiazepines and the development of dementia. DESIGN: Systematic review and meta-analysis of 12 prospective and retrospective cohort studies and case-control studies...
August 11, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/30095057/microencapsulation-of-carvacrol-using-pectin-aloe-gel-as-a-novel-wound-dressing-films
#3
Gabriel Humberto Gomez-Rodriguez, Marco Antonio Lopez-Mata, Edith Valbuena-Gregorio, Ramon Gertrudis Valdez Melchor, Julio Cesar Campos-Garcia, Norma Patricia Silva-Beltran, Luis Quihui-Cota, Saul Ruiz-Cruz, Josue Juarez
Recently, pectin (PEC) and Aloe-gel (AG) have received great attention for their use in the encapsulation of hydrophobic bioactive compounds such as carvacrol (CAR). The aim of this study is to assess the physical, chemical and biological properties of a novel PEC/AG film and evaluate its capability to entrap CAR into microencapsulates. For this purpose, the casting method was used to prepare the PEC/AG membranes (70:30 % w/w). The CAR-loaded PEC/AG film were prepared adding different proportions of CAR (0...
August 10, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/30088931/all-that-binds-is-not-gold-the-relative-weight-of-aurophilic-interactions-in-complex-formation
#4
Axel Wuttke, Milica Feldt, Ricardo A Mata
Often have you heard that told, complexes containing close Au(I) contacts are strongly influenced by what has come to be known as aurophilic interactions. In this work, local orbital analysis is carried out to separate competing metallophilic and other weak interactions at the correlated level in three selected molecular crystals. We carefully separate and discuss the different contributions to the total interaction energy of dimers and trimers according to their spatial location, and identify the relative weight in binding...
August 8, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/30071997/clinical-genetic-testing-for-familial-hypercholesterolemia-jacc-scientific-expert-panel
#5
REVIEW
Amy C Sturm, Joshua W Knowles, Samuel S Gidding, Zahid S Ahmad, Catherine D Ahmed, Christie M Ballantyne, Seth J Baum, Mafalda Bourbon, Alain Carrié, Marina Cuchel, Sarah D de Ferranti, Joep C Defesche, Tomas Freiberger, Ray E Hershberger, G Kees Hovingh, Lala Karayan, Johannes Jacob Pieter Kastelein, Iris Kindt, Stacey R Lane, Sarah E Leigh, MacRae F Linton, Pedro Mata, William A Neal, Børge G Nordestgaard, Raul D Santos, Mariko Harada-Shiba, Eric J Sijbrands, Nathan O Stitziel, Shizuya Yamashita, Katherine A Wilemon, David H Ledbetter, Daniel J Rader
Although awareness of familial hypercholesterolemia (FH) is increasing, this common, potentially fatal, treatable condition remains underdiagnosed. Despite FH being a genetic disorder, genetic testing is rarely used. The Familial Hypercholesterolemia Foundation convened an international expert panel to assess the utility of FH genetic testing. The rationale includes the following: 1) facilitation of definitive diagnosis; 2) pathogenic variants indicate higher cardiovascular risk, which indicates the potential need for more aggressive lipid lowering; 3) increase in initiation of and adherence to therapy; and 4) cascade testing of at-risk relatives...
August 7, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/30058187/development-of-a-food-frequency-questionnaire-for-brazilian-athletes
#6
Allan da Mata Godois, Christianne de Faria Coelho-Ravagnani, Raquel Raizel, Eliseu Verly-Junior
AIM: Until recently most dietary survey methods have been developed for non-athletic populations. In this study, we aimed to develop a Food Frequency Questionnaire (FFQ) to assess the regular dietary intake of Brazilian athletes. METHODS: We interviewed 141 athletes (23.36 ± 7.77 years old) for their dietary intake using 24-hour recalls. After grouping conceptually similar food items into 113 food items, percentage contribution analysis and stepwise regression models were used to highlight foods contributing to at least 90% of the between-person variability of key nutrients...
July 29, 2018: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/30050778/real-world-data-of-nivolumab-for-previously-treated-non-small-cell-lung-cancer-patients-a-galician-lung-cancer-group-clinical-experience
#7
Mª Carmen Areses Manrique, Joaquín Mosquera Martínez, Jorge García González, Francisco Javier Afonso Afonso, Martín Lázaro Quintela, Natalia Fernández Núñez, Cristina Azpitarte Raposeiras, Margarita Amenedo Gancedo, Lucía Santomé Couto, Mª Rosario García Campelo, Jose Muñoz Iglesias, Alexandra Cortegoso Mosquera, Rocío Vilchez Simo, Joaquín Casal Rubio, Begoña Campos Balea, Iria Carou Frieiro, Guillermo Alonso-Jaudenes Curbera, Urbano Anido Herranz, Jesus García Mata, José Luis Fírvida Pérez
Background: Recently, immunotherapy has changed the standard of treatment in non-small cell lung cancer (NSCLC). Outside clinical trials, data of real life is lacking. This is an observational study that represents the real world experience with nivolumab in pretreated NSCLC. Methods: Eligibility criteria included, histologically confirmed NSCLC, stage IIIB and IV, evaluable disease and at least one prior therapy. Patients received nivolumab until progressive disease (PD) or unacceptable toxicity...
June 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/30049290/persistent-accumulation-of-unrepaired-dna-damage-in-rat-cortical-neurons-nuclear-organization-and-chip-seq-analysis-of-damaged-dna
#8
Jorge Mata-Garrido, Olga Tapia, Iñigo Casafont, Maria T Berciano, Ana Cuadrado, Miguel Lafarga
Neurons are highly vulnerable to DNA damage induced by genotoxic agents such as topoisomerase activity, oxidative stress, ionizing radiation (IR) and chemotherapeutic drugs. To avert the detrimental effects of DNA lesions in genome stability, transcription and apoptosis, neurons activate robust DNA repair mechanisms. However, defective DNA repair with accumulation of unrepaired DNA are at the basis of brain ageing and several neurodegenerative diseases. Understanding the mechanisms by which neurons tolerate DNA damage accumulation as well as defining the genomic regions that are more vulnerable to DNA damage or refractory to DNA repair and therefore constitute potential targets in neurodegenerative diseases are essential issues in the field...
July 26, 2018: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/30046019/fabrication-of-crack-free-nickel-based-superalloy-considered-non-weldable-during-laser-powder-bed-fusion
#9
Oscar Sanchez-Mata, Xianglong Wang, Jose Alberto Muñiz-Lerma, Mohammad Attarian Shandiz, Raynald Gauvin, Mathieu Brochu
Crack-free Hastelloy X fabricated through laser powder bed fusion (LPBF) from powder with a standard chemical composition is reported. Electron backscatter diffraction (EBSD) analysis evidenced columnar grains parallel to the building direction. The typical LPBF columnar dendrite microstructure was found to be finer than reported elsewhere. Mo-enriched carbides (~50 nm), presumed to play an important role in the cracking behavior of the alloy, were confirmed along interdendritic regions. Crack-free condition was maintained after heat treatment at 1177 °C for 1 h followed by water quenching, and the resulting microstructure was analyzed...
July 25, 2018: Materials
https://www.readbyqxmd.com/read/30033267/green-synthesized-silver-nanoparticles-catalytic-dye-degradation-in-vitro-anticancer-activity-and-in-vivo-toxicity-in-rats
#10
Jayachandra Reddy Nakkala, Rani Mata, Kumar Raja, Varshney Khub Chandra, Sudha Rani Sadras
In this study, silver nanoparticles were synthesized (AgNPs) using aqueous rhizome extract of Acorus calamus (ACRE) and evaluated their in vitro anticancer activity and in vivo toxicity in a Wistar rat model. The synthesized AgNPs showed good catalytic activity against different organic pollutant dyes. In vitro cytotoxic effects of AgNPs were assessed in Hep2, COLO 205 and SH-SY5Y cells using MTT assay. Further, the apoptotic changes induced by AgNPs in more susceptible Hep2 cells were observed through AO/EB, DCFH-DA, Rhodamine 123, PI/DAPI staining, oxidative stress markers and Western blotting...
October 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30029548/comparative-evaluation-of-indirect-immunofluorescence-and-ns-1-based-elisa-to-determine-zika-virus-specific-igm
#11
Fernando De Ory, María Paz Sánchez-Seco, Ana Vázquez, María Dolores Montero, Elena Sulleiro, Miguel J Martínez, Lurdes Matas, Francisco J Merino
Differential diagnosis of the Zika virus (ZIKV) is hampered by cross-reactivity with other flaviviruses, mainly dengue viruses. The aim of this study was to compare two commercial methods for detecting ZIKV immunoglobulin M (IgM), an indirect immunofluorescence (IIF) and an enzyme immunoassay (ELISA), using the non-structural (NS) 1 protein as an antigen, both from EuroImmun, Germany. In total, 255 serum samples were analyzed, 203 of which showed laboratory markers of ZIKV infections (PCR-positive in serum and/or in urine and/or positive or indeterminate specific IgM)...
July 19, 2018: Viruses
https://www.readbyqxmd.com/read/30021893/the-rna-binding-protein-of-a-double-stranded-rna-virus-acts-like-a-scaffold-protein
#12
Carlos P Mata, Johann Mertens, Juan Fontana, Daniel Luque, Carolina Allende-Ballestero, David Reguera, Benes L Trus, Alasdair C Steven, José L Carrascosa, José R Castón
Infectious bursal disease virus (IBDV), a non-enveloped, double-stranded (ds)RNA virus with a T=13 icosahedral capsid, has a virion assembly strategy that initiates with a precursor particle based on an internal scaffold shell similar to that of tailed dsDNA viruses. In IBDV-infected cells, the assembly pathway results mainly in mature virions that package four dsRNA segments, although minor viral populations ranging from zero to three dsRNA segments also form. We used cryo-electron microscopy, cryo-electron tomography and atomic force microscopy to characterize these IBDV populations...
July 18, 2018: Journal of Virology
https://www.readbyqxmd.com/read/30018423/additional-%C3%AE-glucosidase-inhibitors-from-malbranchea-flavorosea-leotiomycetes-ascomycota
#13
Daniela Rebollar-Ramos, Martha L Macías-Ruvalcaba, Mario Figueroa, Huzefa A Raja, Martín González-Andrade, Rachel Mata
From the rice-based culture of Malbranchea flavorosea, three new compounds namely flavoroseoside B (5-desoxy-5-chloro-flavoroseoside) (2), 4-hydroxy-2-O-α-ribofuranosyl-5-methylacetophenone (3), and (S)-3,4-dihydro-3-(1H-indol-3-ylmethyl)-4-methyl-1H-1,4-benzodiazepine-2,5-dione (4), along with three known compounds, rosigenin (5), massarilactone B (6), and riboxylarinol B (7) were obtained. The structures were determined by spectroscopic methods. Compound 4 and its synthetic analog 3,4-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-1H-1,4-benzodiazepine-2,5-dione (9) inhibited the activity of Ruminococus obeum α-glucosidase enzyme...
July 17, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/30013690/the-phenyl-vinyl-ether-methanol-complex-a-model-system-for-quantum-chemistry-benchmarking
#14
Dominic Bernhard, Fabian Dietrich, Mariyam Fatima, Cristóbal Pérez, Hannes C Gottschalk, Axel Wuttke, Ricardo A Mata, Martin A Suhm, Melanie Schnell, Markus Gerhards
The structure of the isolated aggregate of phenyl vinyl ether and methanol is studied by combining a multi-spectroscopic approach and quantum-chemical calculations in order to investigate the delicate interplay of noncovalent interactions. The complementary results of vibrational and rotational spectroscopy applied in molecular beam experiments reveal the preference of a hydrogen bond of the methanol towards the ether oxygen (OH∙∙∙O) over the π-docking motifs via the phenyl and vinyl moieties, with an additional less populated OH∙∙∙P(phenyl)-bound isomer detected only by microwave spectroscopy...
2018: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/30003958/characterization-and-localization-of-primordial-germ-cells-in-totoaba-macdonaldi
#15
Raquel Escuredo-Vielba, Miguel A Del Río-Portilla, Jose Antonio Mata-Sotres, Benjamín Barón-Sevilla, Yanet Guerrero-Rentería, Carmen G Paniagua-Chávez
The totoaba, Totoaba macdonaldi, is an endangered fish of the Gulf of California with high economic and ecological potential. Therefore, our purpose was to characterize the Primordial Germ Cells (PGCs) of this Sciaenid with two objectives: (1) to provide the basis for PGCs cryopreservation to preserve the genetic resources and (2) to take the first step to know the gonadal genesis and sex differentiation of totoaba. Immunofluorescence analysis performed from 2-cell stage to 8-day after hatch (DAH) shows that Vasa protein is specific for PGCs...
July 9, 2018: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/30003902/methylene-blue-activates-the-pmca-activity-and-cross-interacts-with-amyloid-%C3%AE-peptide-blocking-a%C3%AE-mediated-pmca-inhibition
#16
Maria Berrocal, Isaac Corbacho, Carlos Gutierrez-Merino, Ana M Mata
The phenothiazine methylene blue (MB) is attracting increasing attention because it seems to have beneficial effects in the pathogenesis of Alzheimer's disease (AD). Among other factors, the presence of neuritic plaques of amyloid-β peptide (Aβ) aggregates, neurofibrilar tangles of tau and perturbation of cytosolic Ca2+ are important players of the disease. It has been proposed that MB decreases the formation of neuritic plaques due to Aβ aggregation. However, the molecular mechanism underlying this effect is far from clear...
September 1, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29963019/an-antimicrobial-peptide-induces-fig1-dependent-cell-death-during-cell-cycle-arrest-in-yeast
#17
Vladimir J Arellano, Paula Martinell García, Jonathan G Rodríguez Plaza, Maria T Lara Ortiz, Gabriele Schreiber, Rudolf Volkmer, Edda Klipp, Gabriel Del Rio
Although most antibiotics act on cells that are actively dividing and non-dividing cells such as in microbe sporulation or cancer stem cells represent a new paradigm for the control of disease. In addition to their relevance to health, such antibiotics may promote our understanding of the relationship between the cell cycle and cell death. No antibiotic specifically acting on microbial cells arrested in their cell cycle has been identified until the present time. In this study we used an antimicrobial peptide derived from α-pheromone, IP-1, targeted against MATa Saccharomyces cerevisiae cells in order to assess its dependence on cell cycle arrest to kill cells...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29940083/how-much-is-enough-effects-of-technical-and-biological-replication-on-metabarcoding-dietary-analysis
#18
Vanessa A Mata, Hugo Rebelo, Francisco Amorim, Gary F McCracken, Simon Jarman, Pedro Beja
DNA metabarcoding is increasingly used in dietary studies to estimate diversity, composition and frequency of occurrence of prey items. However, few studies have assessed how technical and biological replication affect the accuracy of diet estimates. This study addresses these issues using the European free-tailed bat Tadarida teniotis, involving high-throughput sequencing of a small fragment of the COI gene in 15 separate faecal pellets and a 15-pellet pool per each of 20 bats. We investigated how diet descriptors were affected by variability among (a) individuals, (b) pellets of each individual and (c) PCRs of each pellet...
June 25, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29937273/cost-effectiveness-and-budget-impact-of-treatment-with-evolocumab-versus-statins-and-ezetimibe-for-hypercholesterolemia-in-spain
#19
Antonio Olry de Labry Lima, Vicente Gimeno Ballester, Jesús Francisco Sierra Sánchez, Antonio Matas Hoces, Julio González-Outón, Emilio Jesús Alegre Del Rey
INTRODUCTION AND OBJECTIVES: To analyze the cost-effectiveness ratio and budget impact of treatment with evolocumab (PCSK9 inhibitor) for patients in secondary prevention in the Spanish National Health System. METHODS: A budget impact analysis, decision tree and Markov models were designed under the public health system perspective, based on the only study with morbidity and mortality data (FOURIER). The alternatives compared were evolocumab vs statins, and dual therapy with ezetimibe in 5% of the population...
June 21, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29929208/dna-barcoding-for-the-identification-of-phyllanthus-taxa-used-medicinally-in-brazil
#20
Peter W Inglis, Lorena R Mata, Marcos José da Silva, Roberto F Vieira, Rosa de B N Alves, Dijalma B Silva, Vânia C R Azevedo
Plants of the genus Phyllanthus, principally Phyllanthus amarus, Phyllanthus urinaria, Phyllanthus niruri , and Phyllanthus tenellus, are used in Brazilian folk medicine to treat kidney stones as well as other ailments, where the latter two species are listed in the Brazilian Pharmacopeia as quebra-pedra ( stone-breaker ). However, only P. niruri has been shown to be effective in a clinical setting. Nuclear ribosomal internal transcribed spacer (ITS1 - 5.8S rRNA-ITS2), internal transcribed spacer 2, and chloroplasts rbc L, mat K, psb A- trn H, trn L, and trn L- trn F were screened for their potential as DNA barcodes for the identification of 48 Phyllanthus taxa in Brazilian medicinal plant germplasm banks and in "living pharmacies"...
June 21, 2018: Planta Medica
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