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https://www.readbyqxmd.com/read/30080660/risk-factors-and-quality-of-life-for-the-occurrence-of-hip-fracture-in-postmenopausal-women
#1
Fang-Ping Chen, Tsai-Sheng Fu, Yu-Ching Lin, Chih-Ming Fan
BACKGROUND: To identify the risk factors and changes of quality of life in the first occurrence of hip fracture in Taiwanese postmenopausal women. METHODS: In this case-control study, we enrolled 100 postmenopausal women with accidental first-incident hip fracture and 100 women without hip fracture. The control group was matched to the study group according to age. Evaluation consisted of a questionnaire, an interview to both assess quality of life via a 36-item Short Form Health Survey and document risk factors, a physical examination to record height and body weight, and bone mineral density (BMD) of the hip and spine using dual-energy X-ray absorptiometry (DXA)...
June 2018: Biomedical Journal
https://www.readbyqxmd.com/read/30051403/sex-specific-cardiovascular-comorbidities-with-associations-in-dermatologic-and-rheumatic-disorders
#2
Peter L M Kerkhof, Irina Khamaganova
Cardiology, dermatology, and rheumatology form a fascinating triad. Many skin and joint disorders are associated with cardiovascular comorbidities because they share etiologic elements. Female predominance is often remarkable and likely related to autoimmune pathology. Although studies have shown that X-encoded genes may be involved in the differences in immunity between males and females, other studies have also shown that sex chromosomes are irrelevant and that estrogens and androgens are responsible for the differences...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30034392/attenuation-of-rheumatoid-inflammation-by-sodium-butyrate-through-reciprocal-targeting-of-hdac2-in-osteoclasts-and-hdac8-in-t-cells
#3
Da Som Kim, Jeong-Eun Kwon, Seung Hoon Lee, Eun Kyung Kim, Jun-Geol Ryu, Kyung-Ah Jung, Jeong-Won Choi, Min-Jung Park, Young-Mee Moon, Sung-Hwan Park, Mi-La Cho, Seung-Ki Kwok
Rheumatoid arthritis (RA) is a systemic autoimmune disease caused by both genetic and environmental factors. Recently, investigators have focused on the gut microbiota, which is thought to be an environmental factor that affects the development of RA. Metabolites secreted by the gut microbiota maintain homeostasis in the gut through various mechanisms [e.g., butyrate, which is one of the major metabolites of gut microbiota, exerts an anti-inflammatory effect by activating G-protein-coupled receptors and inhibiting histone deacetylases (HDACs)]...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29720252/estrogen-induces-st6gal1-expression-and-increases-igg-sialylation-in-mice-and-patients-with-rheumatoid-arthritis-a-potential-explanation-for-the-increased-risk-of-rheumatoid-arthritis-in-postmenopausal-women
#4
Cecilia Engdahl, Albert Bondt, Ulrike Harre, Jasmin Raufer, René Pfeifle, Alessandro Camponeschi, Manfred Wuhrer, Michaela Seeling, Inga-Lill Mårtensson, Falk Nimmerjahn, Gerhard Krönke, Hans U Scherer, Helena Forsblad-d'Elia, Georg Schett
BACKGROUND: Rheumatoid arthritis (RA) preferentially affects women, with the peak incidence coinciding with estrogen decrease in menopause. Estrogen (E2) may therefore have intrinsic immune-regulatory properties that vanish with menopause. Fc sialylation is a crucial factor determining the inflammatory effector function of antibodies. We therefore analyzed whether E2 affects immunoglobulin G (IgG) sialylation. METHODS: Postmenopausal (ovariectomized) mice were immunized with ovalbumin and treated with E2 or vehicle...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29644763/correlation-of-quality-of-life-with-risk-factors-for-first-incident-hip-fracture-in-postmenopausal-women
#5
Fang-Ping Chen, Tsai-Sheng Fu, Yu-Ching Lin, Chih-Ming Fan
AIM: The aim of this study was to identify the correlation between health-related quality of life (HRQOL) and risk factors of first-incidence hip fracture in postmenopausal women. METHODS: This case-control study included 99 postmenopausal women with first-incident hip fracture and 101 women without hip fracture who were matched according to age. Evaluation consisted of clinical factors, 36-item Short-Form Health Survey (SF-36) and dual-energy X-ray absorptiometry for bone mineral density of hip and spine...
June 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29144542/autoimmune-diseases-and-breast-cancer-risk-by-tumor-hormone-receptor-status-among-elderly-women
#6
Catherine Schairer, Ruth M Pfeiffer, Shahinaz M Gadalla
The female preponderance of many autoimmune diseases suggests a possible hormonal etiology. Little research exists on systemic and organ-specific autoimmune diseases and risk of breast cancer by tumor estrogen receptor (ER)- and progesterone receptor (PR)- status. Here, we evaluate associations between selected systemic and organ-specific autoimmune diseases and breast cancer risk overall and by tumor ER- and PR-status. We used linked Surveillance, Epidemiology and End Results (SEER)-Medicare data, with first female breast cancer cases ages ≥66 years identified by SEER registries (years 1992-2011; N = 209,929)...
March 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28868359/immune-mediator-pharmacogenomics-tcl1a-snps-and-estrogen-dependent-regulation-of-inflammation
#7
Ming-Fen Ho, Richard M Weinshilboum
This review describes the important functional implications of TCL1A single nucleotide polymorphisms (SNPs) discovered during pharmacogenomic studies of aromatase inhibitor-induced musculoskeletal adverse events that were subsequently shown to influence the expression of cytokines, chemokines, toll-like receptors (TLR), and NF-κB in a SNP and estrogen-dependent fashion. Functional genomic studies of these SNPs led to the discovery of novel mechanisms that may contribute to disease pathophysiology and which may also increase our understanding of pharmacogenomic aspects of regulation of the expression of inflammatory mediators...
August 2017: Journal of Nature and Science
https://www.readbyqxmd.com/read/28706407/incidence-of-oral-lichen-planus-in-perimenopausal-women-a-cross-sectional-study-in-western-uttar-pradesh-population
#8
Ravi Prakash Sasankoti Mohan, Akanksha Gupta, Nagaraju Kamarthi, Sangeeta Malik, Sumit Goel, Swati Gupta
BACKGROUND: Hormonal fluctuations during menopause lead to endocrine changes in women, especially in their sex steroid hormone production. Studies have documented the role of estrogen and progesterone (Pg) on autoimmune disorders such as multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. Lichen planus (LP), an autoimmune disorder, seen frequently in perimenopausal women, may also get affected by sex steroid hormones, but no direct relationship has been established yet...
April 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28666971/postmenopausal-osteoporosis-in-rheumatoid-arthritis-the-estrogen-deficiency-immune-mechanisms-link
#9
REVIEW
Rony Sapir-Koren, Gregory Livshits
Rheumatoid arthritis (RA) is characterized, among other factors, by systemic bone loss, reaching ~50% prevalence of osteoporosis in postmenopausal women. This is roughly a doubled prevalence in comparison with age-matched non-RA women. Postmenopausal RA women are more likely to be sero-positive for the anti-citrullinated peptide antibody (ACPA). Our extensive review of recent scientific literature enabled us to propose several mechanisms as responsible for the accelerated bone loss in ACPA(+) RA postmenopausal women...
October 2017: Bone
https://www.readbyqxmd.com/read/28554684/ovarian-hormones-in-innate-inflammation
#10
Alexandra Stubelius, Annica Andersson, Ulrika Islander, Hans Carlsten
AIM: A more vigorous immune system activation is generally seen in women as compared to men. The reasons for these differences are still not understood. By investigating the immune-regulatory role of estrogens, we have previously shown that estradiol (E2) can regulate and ameliorate rheumatoid arthritis models. The aim of this study was to elucidate the role of ovariectomy (ovx) and estradiol (E2) in innate immune responses. METHODS: Female mice were ovx or sham operated...
August 2017: Immunobiology
https://www.readbyqxmd.com/read/28375935/estriol-emerging-clinical-benefits
#11
REVIEW
Emad S Ali, Cheyenne Mangold, Alan N Peiris
OBJECTIVE: Estriol is the main estrogen in pregnancy, but has received less attention outside gestation. It is well known that pregnancy has an immunosuppressive effect on many autoimmune diseases such as multiple sclerosis, psoriasis, thyroiditis, uveitis, and rheumatoid arthritis. Emerging evidence indicates that estriol has potential immunomodulatory benefits for many disease states including autoimmune, inflammatory, and neurodegenerative conditions. In this review, we discuss emerging roles for estriol in the treatment of menopausal symptoms, osteoporosis, cancer, hyperlipidemia, vascular disease, and multiple sclerosis...
September 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28234966/the-single-nucleotide-variant-rs12722489-determines-differential-estrogen-receptor-binding-and-enhancer-properties-of-an-il2ra-intronic-region
#12
Marina A Afanasyeva, Lidia V Putlyaeva, Denis E Demin, Ivan V Kulakovskiy, Ilya E Vorontsov, Marina V Fridman, Vsevolod J Makeev, Dmitry V Kuprash, Anton M Schwartz
We studied functional effect of rs12722489 single nucleotide polymorphism located in the first intron of human IL2RA gene on transcriptional regulation. This polymorphism is associated with multiple autoimmune conditions (rheumatoid arthritis, multiple sclerosis, Crohn's disease, and ulcerative colitis). Analysis in silico suggested significant difference in the affinity of estrogen receptor (ER) binding site between alternative allelic variants, with stronger predicted affinity for the risk (G) allele. Electrophoretic mobility shift assay showed that purified human ERα bound only G variant of a 32-bp genomic sequence containing rs12722489...
2017: PloS One
https://www.readbyqxmd.com/read/27649785/il-18bp-is-decreased-in-osteoporotic-women-prevents-inflammasome-mediated-il-18-activation-and-reduces-th17-differentiation
#13
Mohd Nizam Mansoori, Priyanka Shukla, Manisha Kakaji, Abdul M Tyagi, Kamini Srivastava, Manoj Shukla, Manisha Dixit, Jyoti Kureel, Sushil Gupta, Divya Singh
IL-18BP is a natural antagonist of pro-inflammatory IL-18 cytokine linked to autoimmune disorders like rheumatoid arthritis. However, its role in post menopausal osteoporosis is still unknown. In this study, we investigated the role of IL-18BP on murine osteoblasts, its effect on osteoblasts-CD4+ T cells and osteoblasts-CD11b+ macrophage co-culture. mIL-18BPd enhances osteoblast differentiation and inhibits the activation of NLRP3 inflammasome and caspase-1 which process IL-18 to its active form. Using estrogen deficient mice, we also determined the effect of mIL-18BP on various immune and skeletal parameters...
September 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27608794/the-negative-bone-effects-of-the-disease-and-of-chronic-corticosteroid-treatment-in-premenopausal-women-affected-by-rheumatoid-arthritis
#14
A Fassio, L Idolazzi, M A Jaber, C Dartizio, O Viapiana, M Rossini, D Gatti
Osteoporosis is a well-known extra-articular complication in rheumatoid arthritis (RA). The chronic corticosteroid treatment, the functional impairment associated with RA and the disease itself appear to be the most relevant determinants. Most of the previous studies involved postmenopausal women, in whom the estrogenic deficiency might amplify the negative effect towards bone of both RA and corticosteroid therapy. We decided to evaluate bone health in a cohort of premenopausal RA patients. The study population includes 47 premenopausal women attending our outpatient clinic for RA and twice as many healthy age-matched control women selected from the hospital personnel...
September 9, 2016: Reumatismo
https://www.readbyqxmd.com/read/27364395/sex-based-differences-in-autoimmune-diseases
#15
REVIEW
Elena Ortona, Marina Pierdominici, Angela Maselli, Caterina Veroni, Francesca Aloisi, Yehuda Shoenfeld
Autoimmune diseases are characterized by an exaggerated immune response leading to damage and dysfunction of specific or multiple organs and tissues. Most autoimmune diseases are more prevalent in women than in men. Symptom severity, disease course, response to therapy and overall survival may also differ between males and females with autoimmune diseases. Sex hormones have a crucial role in this sex bias, with estrogens being potent stimulators of autoimmunity and androgens playing a protective role. Accumulating evidence indicates that genetic, epigenetic and environmental factors may also contribute to sex-related differences in risk and clinical course of autoimmune diseases...
April 2016: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/27178986/rheumatoid-arthritis-onset-in-postmenopausal-women-does-the-acpa-seropositive-subset-result-from-genetic-effects-estrogen-deficiency-skewed-profile-of-cd4-t-cells-and-their-interactions
#16
REVIEW
Rony Sapir-Koren, Gregory Livshits
Rheumatoid arthritis (RA) incidence displays a differentiated age-dependent female-to-male ratio in which women outnumber men. Evidence that the peak incidence of RA in women coincides with menopause age, suggests a potential estrogenic role to disease etiology. Estrogens exert physiologically both stimulatory and inhibitory effects on the immune system. Epidemiologic and animal model studies with estrogen deprivation or supplementation suggested estrogens as to play, mainly, a protective role in RA immunopathology...
August 15, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27178283/time-trends-in-osteoporosis-risk-factor-profiles-a-comparative-analysis-of-risk-factors-comorbidities-and-medications-over-twelve-years
#17
Jakob Præst Holm, Lars Hyldstrup, Jens-Erik Beck Jensen
The aim of this article was to identify prevalent osteoporosis risk factors, medications and comorbidities associated with bone mineral density (BMD). Furthermore to evaluate changes in risk factor profiles over 12 years. 6285 women consecutively referred to an osteoporosis specialist clinic were included. Information of potential risk factors was obtained by questionnaire and clinical examination. Additional information on medication use, comorbidities and fractures were obtained from national registries...
October 2016: Endocrine
https://www.readbyqxmd.com/read/26861296/the-role-of-cdkn1a-interacting-zinc-finger-protein-1-ciz1-in-dna-replication-and-pathophysiology
#18
REVIEW
Qiang Liu, Na Niu, Youichiro Wada, Ju Liu
Cdkn1A-interacting zinc finger protein 1 (CIZ1) was first identified in a yeast-2-hybrid system searching for interacting proteins of CDK2 inhibitor p21(Cip1/Waf1). Ciz1 also binds to CDK2, cyclin A, cyclin E, CDC6, PCNA, TCF4 and estrogen receptor-α. Recent studies reveal numerous biological functions of CIZ1 in DNA replication, cell proliferation, and differentiation. In addition, splicing variants of CIZ1 mRNA is associated with a variety of cancers and Alzheimer's disease, and mutations of the CIZ1 gene lead to cervical dystonia...
February 5, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26745543/suppression-of-experimental-arthritis-and-associated-bone-loss-by-a-tissue-selective-estrogen-complex
#19
Annica Andersson, Angelina I Bernardi, Merja Nurkkala-Karlsson, Alexandra Stubelius, Louise Grahnemo, Claes Ohlsson, Hans Carlsten, Ulrika Islander
In addition to the systemic inflammation present in rheumatoid arthritis (RA), decreased estradiol levels in postmenopausal RA patients further accelerate bone loss in these patients. The tissue-selective estrogen complex (TSEC), an estrogen combined with a selective estrogen receptor modulator, is a new hormone replacement therapy option. The first approved TSEC, containing conjugated estrogens and bazedoxifene (BZA), reduces menopausal symptoms and prevents osteoporosis with an improved safety profile compared with conventional hormone replacement therapy...
March 2016: Endocrinology
https://www.readbyqxmd.com/read/26458737/definition-and-initial-validation-of-a-lupus-low-disease-activity-state-lldas
#20
Kate Franklyn, Chak Sing Lau, Sandra V Navarra, Worawit Louthrenoo, Aisha Lateef, Laniyati Hamijoyo, C Singgih Wahono, Shun Le Chen, Ou Jin, Susan Morton, Alberta Hoi, Molla Huq, Mandana Nikpour, Eric F Morand
AIMS: Treating to low disease activity is routine in rheumatoid arthritis, but no comparable goal has been defined for systemic lupus erythematosus (SLE). We sought to define and validate a Lupus Low Disease Activity State (LLDAS). METHODS: A consensus definition of LLDAS was generated using Delphi and nominal group techniques. Criterion validity was determined by measuring the ability of LLDAS attainment, in a single-centre SLE cohort, to predict non-accrual of irreversible organ damage, measured using the Systemic Lupus International Collaborating Clinics Damage Index (SDI)...
September 2016: Annals of the Rheumatic Diseases
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