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Wenfang S Wu, Liang Zhu, Saurabh Patil, Karthiga Gokul, Sean Reilly, Joyce Chan, Poornima Tekumalla, Vivek Vishnudas, Michael A Kiebish, Rangaprasad Sarangarajan, Viatcheslav R Akmaev, Mark D Kellogg, Niven R Narain
Coiled-Coil Domain Containing 47 (CCDC47) is an endoplasmic reticulum (ER) transmembrane protein involved in calcium signaling through utilization of its calcium binding-acidic luminal domain. CCDC47 also interacts with ERAD (endoplasmic reticulum-associated degradation) complex and is involved in ER stress relief. In this report, we developed human CCDC47 monoclonal antibodies and a sandwich immunoassay for CCDC47 measurement in biological matrices. Specificity of developed antibodies were confirmed by immunoblot and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of immunoprecipitated cell lysates...
January 2018: Journal of Immunological Methods
Priyanka Sharma, Gaurav Garg, Arun Kumar, Farhan Mohammad, Sudha Ramesh Kumar, Vinay Singh Tanwar, Satish Sati, Abhay Sharma, Ganesan Karthikeyan, Vani Brahmachari, Shantanu Sengupta
BACKGROUND: The alteration in the epigenome forms an interface between the genotype and the environment. Epigenetic alteration is expected to make a significant contribution to the development of cardiovascular disease where environmental interactions play a key role in disease progression. We had previously shown that global DNA hypermethylation per se is associated with coronary artery disease (CAD) and is further accentuated by high levels of homocysteine, a thiol amino acid which is an independent risk factor for cardiovascular disease and is also a key modulator of macromolecular methylation...
May 10, 2014: Gene
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