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https://www.readbyqxmd.com/read/30367356/ultrasound-guided-preoperative-localization-of-breast-lesions-a-good-choice
#1
Giorgio Carlino, Pierluigi Rinaldi, Michela Giuliani, Rossella Rella, Enida Bufi, Federico Padovano, Chiara Ciardi, Maurizio Romani, Paolo Belli, Riccardo Manfredi
PURPOSE: The aim of the study was to verify whether ultrasound (US)-guided preoperative localization of breast lesions is an adequate technique for correct and safe surgical resection and to contribute positively and effectively to this topic in the literature with our results. METHODS: From June 2016 to November 2016, 155 patients with both benign and malignant breast lesions were selected from our institute to undergo US localization before surgery. The lesions included were: sonographically visible and nonpalpable lesions; palpable lesions for which a surgeon had requested US localization to better evaluate the site and extension; sonographically visible, multifocal breast lesions, both palpable and nonpalpable...
October 26, 2018: Journal of Ultrasound
https://www.readbyqxmd.com/read/30249463/background-parenchymal-enhancement-in-breast-magnetic-resonance-imaging-a-review-of-current-evidences-and-future-trends
#2
R Rella, E Bufi, P Belli, A Contegiacomo, M Giuliani, M Rosignuolo, P Rinaldi, R Manfredi
Background parenchymal enhancement (BPE) on breast magnetic resonance imaging (MRI) is a dynamic process, which varies among women and within the same woman over time due to different factors. BPE has profound implications for women with or at risk of breast cancer. Breast radiologist should be aware of factors that could potentially influence BPE and have to be familiar with its typical appearance. Marked BPE could indeed affect the diagnostic accuracy of breast MRI, but this shortcoming can be minimized through evaluation by dedicated radiologists, in order to correctly interpret and properly manage the additional findings...
September 21, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/30216597/a-new-risk-stratification-score-for-the-management-of-ultrasound-detected-b3-breast-lesions
#3
Michela Giuliani, Pierluigi Rinaldi, Rossella Rella, Anna D'Angelo, Giorgio Carlino, Amato Infante, Maurizio Romani, Enida Bufi, Paolo Belli, Riccardo Manfredi
To develop a predictive scoring system for ultrasound-detected B3 lesions at ultrasound-guided core needle biopsy (US-CNB). A total of 2724 consecutive US-CNBs performed in our Institution (January 2011 to December 2014) were retrospectively reviewed. Inclusion criteria were as follows: (a) histopathological examination of the entire lesion or (b) availability of radiologic follow-up (FUP) ≥24 months. Patient- and lesion-related variables-patients' age, lesion consistency, lesion size, vascularization, BI-RADS category, and US-CNB result-were analyzed...
September 14, 2018: Breast Journal
https://www.readbyqxmd.com/read/29555568/automated-breast-ultrasonography-abus-in-the-screening-and-diagnostic-setting-indications-and-practical-use
#4
REVIEW
Rossella Rella, Paolo Belli, Michela Giuliani, Enida Bufi, Giorgio Carlino, Pierluigi Rinaldi, Riccardo Manfredi
Automated breast ultrasonography (ABUS) is a new imaging technology for automatic breast scanning through ultrasound. It was first developed to overcome the limitation of operator dependency and lack of standardization and reproducibility of handheld ultrasound. ABUS provides a three-dimensional representation of breast tissue and allows images reformatting in three planes, and the generated coronal plane has been suggested to improve diagnostic accuracy. This technique has been first used in the screening setting to improve breast cancer detection, especiallyin mammographically dense breasts...
March 16, 2018: Academic Radiology
https://www.readbyqxmd.com/read/28594327/different-tcr-induced-t-lymphocyte-responses-are-potentiated-by-stiffness-with-variable-sensitivity
#5
Michael Saitakis, Stéphanie Dogniaux, Christel Goudot, Nathalie Bufi, Sophie Asnacios, Mathieu Maurin, Clotilde Randriamampita, Atef Asnacios, Claire Hivroz
T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We characterize herein how human primary CD4+ T cell functions are affected by stiffness within the physiological Young's modulus range of 0.5 kPa to 100 kPa. Stiffness modulates T lymphocyte migration and morphological changes induced by TCR/CD3 triggering. Stiffness also increases TCR-induced immune system, metabolism and cell-cycle-related genes. Yet, upon TCR/CD3 stimulation, while cytokine production increases within a wide range of stiffness, from hundreds of Pa to hundreds of kPa, T cell metabolic properties and cell cycle progression are only increased by the highest stiffness tested (100 kPa)...
June 8, 2017: ELife
https://www.readbyqxmd.com/read/28342776/effect-of-needle-size-in-ultrasound-guided-core-needle-breast-biopsy-comparison-of-14-16-and-18-gauge-needles
#6
Michela Giuliani, Pierluigi Rinaldi, Rossella Rella, Gina Fabrizi, Federica Petta, Giorgio Carlino, Alba Di Leone, Antonino Mulè, Enida Bufi, Maurizio Romani, Paolo Belli, Lorenzo Bonomo
INTRODUCTION: The aim of the present study was to assess the diagnostic accuracy of ultrasound-guided core needle biopsy (US-CNB) of breast lesions, comparing smaller needles (16- and 18-gauge) with the 14-gauge needle, and to analyze the lesion characteristics influencing US-CNB diagnostic performance. PATIENTS AND METHODS: All the patients provided informed consent before the biopsy procedure. The data from breast lesions that had undergone US-CNB in our institution from January 2011 to January 2015 were retrospectively reviewed...
November 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28272714/role-of-dwi-assessing-nodal-involvement-and-response-to-neoadjuvant-chemotherapy-in-advanced-breast-cancer
#7
P Belli, E Bufi, C Buccheri, P Rinaldi, M Giuliani, M Romani, G Fabrizi, A D'angelo, C Brunelli, A Mule', G Franceschini, C Colosimo
OBJECTIVE: To explore the role of diffusion-weighted imaging (DWI) in the staging of axillary lymph nodes and the restaging after neoadjuvant chemotherapy (NAD) in advanced breast cancer. PATIENTS AND METHODS: MRI examinations of forty-two patients diagnosed with advanced breast cancer addressed to NAD and axillary lymph node dissection (ALND) were reviewed. Apparent diffusion coefficients (ADC) of each visible node in DWI in the pathologic axilla (PA) and healthy axilla (HA) were measured at the time of diagnosis (t0) and after chemotherapy (t1); mean values of the ADC were calculated...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28138953/clinical-benefits-of-unilateral-adrenalectomy-in-patients-with-subclinical-hypercortisolism-due-to-adrenal-incidentaloma-results-from-a-single-center
#8
Luigi Petramala, Giuseppe Cavallaro, Matteo Galassi, Cristiano Marinelli, Gianfranco Tonnarini, Antonio Concistrè, Umberto Costi, Maurizio Bufi, Piernatale Lucia, Giuseppe De Vincentis, Gino Iannucci, Giorgio De Toma, Claudio Letizia
INTRODUCTION: This study was designed to evaluate the results of unilateral laparoscopic adrenalectomy in patients with subclinical hypercortisolism (SH) due to adrenal incidentaloma (AI) concerning the main cardiometabolic disorders. METHODS: We have studied between January 2000 to December 2015, 645 patients with AI (283 males and 362 females; mean age 61.9 ± 10 years) and we found 70 patients with SH (27 males and 43 females; mean age 61.9 ± 8.4 years)...
March 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/27831654/unenhanced-breast-magnetic-resonance-imaging-detection-of-breast-cancer
#9
P Belli, E Bufi, A Bonatesta, F Patrolecco, F Padovano, M Giuliani, P Rinaldi, L Bonomo
OBJECTIVE: To evaluate the diagnostic performance of unenhanced MRI (UE-MRI) for malignant breast lesions and its reproducibility. PATIENTS AND METHODS: We retrospectively included 118 patients who had breast MRI. DWI and STIR images were read in combination and referred to as UE-MRI; the presence or absence of the malignant lesion was noted by two observers. Their results were compared with those of final histopathology or with a two-year negative follow-up for diagnostic performance assessment; ROC curves were built...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27618803/sensitivity-of-breast-mri-for-ductal-carcinoma-in-situ-appearing-as-microcalcifications-only-on-mammography
#10
Pierluigi Rinaldi, Chiara Buccheri, Michela Giuliani, Enida Bufi, Maurizio Romani, Federica Patrolecco, Paolo Belli, Lorenzo Bonomo
PURPOSE: This study aims to investigate sensitivity of breast magnetic resonance imaging (MRI) for mammographic microcalcifications-only ductal carcinoma in situ (DCIS), based on its histopathology and mammographic extent of microcalcifications. METHODS: Mammograms were reviewed to measure the extent of microcalcifications. Sensitivity of MRI was calculated in the overall study population and in groups differing for DCIS nuclear grade, microinvasivity, and microcalcifications' extent...
November 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27431459/hypervascularity-predicts-complete-pathologic-response-to-chemotherapy-and-late-outcomes-in-breast-cancer
#11
Enida Bufi, Paolo Belli, Marialuisa Di Matteo, Michela Giuliani, Mariavalentina Tumino, Pierluigi Rinaldi, Luigia Nardone, Gianluca Franceschini, Antonino Mulé, Lorenzo Bonomo
BACKGROUND: Our objective was to investigate the relationship between asymmetric increase in breast vascularity (AIBV) and pathologic profiles of breast cancer. We also addressed the prognostic performance of AIBV and of vascular maps reduction after neoadjuvant chemotherapy (NAC) in predicting pathologic complete response (pCR) at surgery and outcome at follow-up. MATERIALS AND METHODS: Two hundred nineteen patients with unilateral locally advanced breast cancer (LABC) underwent magnetic resonance imaging before and after NAC...
December 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27262578/magnetic-resonance-imaging-appearance-of-oxidized-regenerated-cellulose-in-breast-cancer-surgery
#12
Michela Giuliani, Rossella Rella, Rita Fubelli, Federica Patrolecco, Silvia Eleonora Di Giovanni, Chiara Buccheri, Federico Padovano, Paolo Belli, Maurizio Romani, Pierluigi Rinaldi, Enida Bufi, Gianluca Franceschini, Lorenzo Bonomo
PURPOSE: To describe magnetic resonance imaging (MRI) findings in patients who underwent breast-conserving surgery followed by oxidized regenerated cellulose (ORC) implantation in surgical cavity. MATERIALS AND METHODS: We retrospectively reviewed 51 MRI examinations performed between January 2009 and January 2014 in 51 patients who underwent BCS with ORC implantation. RESULTS: In 29/51 (57 %) cases, MRIs showed abnormal findings with three main MRI patterns: (1) complex masses: hyperintense collections on T2-weighted (w) images with internal round hypointense nodules without contrast enhancement (55 %); (2) completely hyperintense collections (17 %); and (3) completely hypointense lesions (28 %)...
September 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/26402438/association-between-sonographic-appearances-of-breast-cancers-and-their-histopathologic-features-and-biomarkers
#13
Melania Costantini, Paolo Belli, Enida Bufi, Anna Maria Asunis, Enrico Ferra, Grazia Tomasa Bitti
PURPOSE: The purpose of this study was to investigate potential associations between invasive breast cancer sonographic (US) findings and histopathologic patterns and biomarkers. METHODS: One hundred consecutive women with invasive breast cancer treated in the Breast Diagnostic Center of Brotzu Hospital in Cagliari, Italy, from January to October 2013, were retrospectively evaluated. Two experienced breast radiologists independently evaluated hard copies of US examinations performed during the US-guided biopsy procedure...
January 2016: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/25954876/human-primary-immune-cells-exhibit-distinct-mechanical-properties-that-are-modified-by-inflammation
#14
Nathalie Bufi, Michael Saitakis, Stéphanie Dogniaux, Oscar Buschinger, Armelle Bohineust, Alain Richert, Mathieu Maurin, Claire Hivroz, Atef Asnacios
T lymphocytes are key modulators of the immune response. Their activation requires cell-cell interaction with different myeloid cell populations of the immune system called antigen-presenting cells (APCs). Although T lymphocytes have recently been shown to respond to mechanical cues, in particular to the stiffness of their environment, little is known about the rigidity of APCs. In this study, single-cell microplate assays were performed to measure the viscoelastic moduli of different human myeloid primary APCs, i...
May 5, 2015: Biophysical Journal
https://www.readbyqxmd.com/read/25922282/mammographic-and-ultrasonographic-findings-of-oxidized-regenerated-cellulose-in-breast-cancer-surgery-a-5-year-experience
#15
Michela Giuliani, Rita Fubelli, Federica Patrolecco, Rossella Rella, Cristina Borelli, Chiara Buccheri, Silvia Eleonora Di Giovanni, Paolo Belli, Maurizio Romani, Pierluigi Rinaldi, Enida Bufi, Gianluca Franceschini, Lorenzo Bonomo
BACKGROUND: The purpose of this study was to describe the ultrasonographic (US) and mammographic (MX) findings in patients who underwent breast-conserving surgery followed by oxidized regenerated cellulose (ORC) implantation in the surgical cavity and their size variations in follow-up. MATERIALS AND METHODS: We retrospectively reviewed 417 MX and 743 US images performed between January 2009 and January 2014 for 262 women who underwent breast-conserving surgery...
October 2015: Clinical Breast Cancer
https://www.readbyqxmd.com/read/25891905/role-of-the-apparent-diffusion-coefficient-in-the-prediction-of-response-to-neoadjuvant-chemotherapy-in-patients-with-locally-advanced-breast-cancer
#16
Enida Bufi, Paolo Belli, Melania Costantini, Antonio Cipriani, Marialuisa Di Matteo, Angelo Bonatesta, Gianluca Franceschini, Daniela Terribile, Antonino Mulé, Luigia Nardone, Lorenzo Bonomo
BACKGROUND: We evaluated the diagnostic performance of the baseline diffusion weighted imaging (DWI) and the apparent diffusion coefficient (ADC) in the prediction of a complete pathologic response (pCR) to neoadjuvant chemotherapy (NAC) in patients with breast cancer stratified according to the tumor phenotype. PATIENTS AND METHODS: We retrospectively studied 225 patients with stage II, III, and IV breast cancer who had undergone contrast-enhanced magnetic resonance imaging (MRI) and DWI before and after NAC, followed by breast surgery...
October 2015: Clinical Breast Cancer
https://www.readbyqxmd.com/read/25730854/cells-as-liquid-motors-mechanosensitivity-emerges-from-collective-dynamics-of-actomyosin-cortex
#17
Jocelyn Étienne, Jonathan Fouchard, Démosthène Mitrossilis, Nathalie Bufi, Pauline Durand-Smet, Atef Asnacios
Living cells adapt and respond actively to the mechanical properties of their environment. In addition to biochemical mechanotransduction, evidence exists for a myosin-dependent purely mechanical sensitivity to the stiffness of the surroundings at the scale of the whole cell. Using a minimal model of the dynamics of actomyosin cortex, we show that the interplay of myosin power strokes with the rapidly remodeling actin network results in a regulation of force and cell shape that adapts to the stiffness of the environment...
March 3, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/25640430/single-cell-mechanics-the-parallel-plates-technique
#18
Nathalie Bufi, Pauline Durand-Smet, Atef Asnacios
We describe here the parallel plates technique which enables quantifying single-cell mechanics, either passive (cell deformability) or active (whole-cell traction forces). Based on the bending of glass microplates of calibrated stiffness, it is easy to implement on any microscope, and benefits from protocols and equipment already used in biology labs (coating of glass slides, pipette pullers, micromanipulators, etc.). We first present the principle of the technique, the design and calibration of the microplates, and various surface coatings corresponding to different cell-substrate interactions...
2015: Methods in Cell Biology
https://www.readbyqxmd.com/read/25157134/three-dimensional-cell-body-shape-dictates-the-onset-of-traction-force-generation-and-growth-of-focal-adhesions
#19
Jonathan Fouchard, Célian Bimbard, Nathalie Bufi, Pauline Durand-Smet, Amsha Proag, Alain Richert, Olivier Cardoso, Atef Asnacios
Cell shape affects proliferation and differentiation, which are processes known to depend on integrin-based focal adhesion (FA) signaling. Because shape results from force balance and FAs are mechanosensitive complexes transmitting tension from the cell structure to its mechanical environment, we investigated the interplay between 3D cell shape, traction forces generated through the cell body, and FA growth during early spreading. Combining measurements of cell-scale normal traction forces with FA monitoring, we show that the cell body contact angle controls the onset of force generation and, subsequently, the initiation of FA growth at the leading edge of the lamella...
September 9, 2014: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/25096888/diffusion-magnetic-resonance-imaging-in-breast-cancer-characterisation-correlations-between-the-apparent-diffusion-coefficient-and-major-prognostic-factors
#20
COMPARATIVE STUDY
Paolo Belli, Melania Costantini, Enida Bufi, Giuseppe Giovanni Giardina, Pierluigi Rinaldi, Gianluca Franceschini, Lorenzo Bonomo
PURPOSE: This study was done to investigate the correlation between the apparent diffusion coefficient (ADC) and prognostic factors of breast cancer. MATERIALS AND METHODS: From January 2008 to June 2011, all consecutive patients with breast cancer who underwent breast magnetic resonance imaging (MRI) and subsequent surgery in our hospital were enrolled in our study. The MRI protocol included a diffusion-weighted imaging sequence with b values of 0 and 1,000 s/mm(2)...
March 2015: La Radiologia Medica
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