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granulation tissue

Afrida Rahman, Janet Weber, Edward Labin, Cary Lai, Anne L Prieto
Neuregulin-3 (Nrg3) is a member of the Nrg family of growth factors identified as risk factors for schizophrenia. There are three Nrgs expressed in the nervous system (Nrg1-3) and of these Nrg1 has been the best characterized. To set the groundwork for elucidating neural roles for Nrg3, we studied its expression in the rat brain at both the RNA and protein levels. Using an antibody developed against Nrg3, we observed a developmental increase of Nrg3 protein expression from embryonic stages to adulthood and determined that it carries O-linked carbohydrates...
October 16, 2018: Journal of Comparative Neurology
Nicole Edwards, Denis Feliers, Qingwei Zhao, Randolph Stone, Robert Christy, Xingguo Cheng
Chronic wounds complicated by diabetes are a significant clinical issue, and their occurrence is expected to continue to rise due to an increased prevalence of diabetes mellitus, especially type 2 diabetes. Diabetic wounds frequently lead to nonhealing ulcers, and often eventually result in limb amputation due to the high risk of infection of the chronic wound. Here, we present a tissue-engineered treatment that combines a novel electrochemically deposited collagen wound matrix and human adipose-derived stem cells...
October 2018: Journal of Biomaterials Applications
İrfan Çelebi, Gülpembe Bozkurt, Abdullah Soydan Mahmutoğlu, Umman Guliyev
OBJECTIVES: To describe and quantify computed tomography (CT) findings of auto-evacuated (spontaneously drained) secondary acquired cholesteatoma (SAC). MATERIALS AND METHODS: This multicenter retrospective study included 69 patients with intermittent ear discharge diagnosed with SAC by autoscopy or automicroscopy who were surgically treated. Three independent radiologists measured the medial and lateral attic distance on coronal and axial planes using multidetector computed tomography (MDCT) in 75 ear CTs from 69 patients with intraoperatively verified diagnoses of pars flaccida cholesteatoma (n=36), pars tensa cholesteatoma (n=24), and auto-atticotomy or automastoidectomy (n=15) and compared them with contralateral healthy ears...
October 13, 2018: Journal of International Advanced Otology
Yujin Ohsugi, Akira Aoki, Koji Mizutani, Sayaka Katagiri, Motohiro Komaki, Masahiro Noda, Toru Takagi, Sho Kakizaki, Walter Meinzer, Yuichi Izumi
The Er:YAG laser is currently used for bone ablation. However, the effect of Er:YAG laser irradiation on bone healing remains unclear. The aim of this study was to investigate bone healing following ablation by laser irradiation as compared with bur drilling. Rat calvarial bone was ablated using Er:YAG laser or bur with water coolant. Er:YAG laser effectively ablated bone without major thermal changes. In-vivo micro-CT analysis revealed that laser irradiation showed significantly higher bone repair ratios than bur drilling...
October 15, 2018: Journal of Biophotonics
Haley Desjardins, Lifei Guo
Chronic wounds are frequently difficult, expensive to treat, and pose a significant burden on both the patient's quality of life and health care system. Their recalcitrance to treatment stems from multiple factors, particularly the presence of bacterial biofilms within the wound bed. However, a commonly overlooked modality in the field of wound care, pressurized irrigation, offers an inexpensive mechanical debridement force capable of dislodging these biofilms that contribute to delayed healing of chronic wounds...
August 2018: Plastic and Reconstructive Surgery. Global Open
Andrea Díaz-Roa, Manuel A Patarroyo, Felio J Bello, Pedro I Da Silva
Larval therapy (LT) is an alternative treatment for healing chronic wounds; its action is based on debridement, the removal of bacteria, and stimulating granulation tissue. The most important mechanism when using LT for combating infection depends on larval excretions and secretions (ES). Larvae are protected against infection by a spectrum of antimicrobial peptides (AMPs); special interest in AMPs has also risen regarding understanding their role in wound healing since they degrade necrotic tissue and kill different bacteria during LT...
2018: Frontiers in Microbiology
Yoshiaki Tanaka, Fumihiko Toyoda, Machiko Shimmura-Tomita, Nozomi Kinoshita, Hiroko Takano, Yoh Dobashi, Shigeki Yamada, Hiroto Obata, Akihiro Kakehashi
Purpose: The aim of this case series was to clarify the clinicopathological features of epiretinal membranes (ERMs) that developed in eyes after silicone oil (SO) tamponade to treat rhegmatog-enous retinal detachments (RRDs). Patients and methods: In the Department of Ophthalmology, Saitama Medical Center, Jichi Medical University, patients with idiopathic ERMs (23 eyes) and ERMs in eyes filled with SO (SO ERMs) after vitreous surgery to treat RRDs (nine eyes) were enrolled from July 2012 to March 2014...
2018: Clinical Ophthalmology
Ishaan Gupta, Paul G Collier, Bettina Haase, Ahmed Mahfouz, Anoushka Joglekar, Taylor Floyd, Frank Koopmans, Ben Barres, August B Smit, Steven A Sloan, Wenjie Luo, Olivier Fedrigo, M Elizabeth Ross, Hagen U Tilgner
Full-length RNA sequencing (RNA-Seq) has been applied to bulk tissue, cell lines and sorted cells to characterize transcriptomes, but applying this technology to single cells has proven to be difficult, with less than ten single-cell transcriptomes having been analyzed thus far. Although single splicing events have been described for ≤200 single cells with statistical confidence, full-length mRNA analyses for hundreds of cells have not been reported. Single-cell short-read 3' sequencing enables the identification of cellular subtypes, but full-length mRNA isoforms for these cell types cannot be profiled...
October 15, 2018: Nature Biotechnology
Qing-Chun Fan, Hua Tian, Xu-Kai Wang
OBJECTIVE: This study aims to determine the relationship between the time of autogenous cartilage in vitro and the degree of absorption in animal experiments. METHODS: New Zealand white rabbits were randomly divided into 3 groups according to the time of cartilage in vitro: 1-hour group, 2-hour group, and 3-hour group. A volume of ear cartilage was taken and transplanted into the back, according to the group. After 1 month, the volume was taken out and remeasured...
October 12, 2018: Journal of Craniofacial Surgery
Takahiro Kiyohara, Sei Nakamaru, Mari Miyamoto, Takako Shijimaya, Naoko Nagano, Kaoru Makimura, Hiroyuki Takama, Masashi Akiyama, Hirotsugu Tanimura
A 34-year-old Japanese man presented with an indolent nodule on the right flank. Computed tomography of the chest and abdomen demonstrated a large nodule measuring 55 mm × 50 mm in the abdominal oblique muscle layer of the right flank, and several small nodules were seen in the muscle layer throughout the body and subcutaneous tissue of the lower abdomen. 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography revealed nodular lesions in the bilateral parotid glands, bilateral cervical lymph nodes and lower lobe of the right lung...
October 15, 2018: Journal of Dermatology
Jeannie Devereaux, Kulmira Nurgali, Dimitrios Kiatos, Samy Sakkal, Vasso Apostolopoulos
Platelet-rich plasma is an autologous and safe blood product containing a high concentration of platelets and leucocytes. Platelets, growth factors, leucocytes and plasma are fundamental fibroblast proliferation agents. Leucocytes' plasticity, reparative qualities, cross-talk between cells and capacity to orchestrate diverse outcomes are receiving considerable research attention. Fibroblasts are able to migrate and proliferate into the tissue surrounding a wound and subsequently deposit granulation tissue, which minimises scarring...
November 2018: Maturitas
Amanda L Killeen, Kara M Brock, Rosabel Loya, Cece S Honculada, Phyllis Houston, Jodi L Walters
INTRODUCTION: Chronic ulcerations on weightbearing surfaces of the lower extremities are uniquely challenging and can lead to complications such as infection or amputation. OBJECTIVE: This 3-patient case series of 4 chronic wounds of various etiologies outlines the use of a fully synthetic bioengineered nanomedical scaffold that exhibits durability and allows for cell migration and angiogenesis while resisting enzymatic degradation. MATERIALS AND METHODS: The nanomedical scaffold was rehydrated in sterile saline at room temperature for 3 to 5 minutes until translucent and pliable, then it was fenestrated with a scalpel...
October 2018: Wounds: a Compendium of Clinical Research and Practice
Wenda Wang, Qi Miao
Spontaneous pericardial hematoma is rare, and the diagnosis of spontaneous organized hemopericardium is difficult in some cases. The present study reports a case of a 23-year-old man admitted to our hospital for dyspnea on Sept. 30, 2017. The patient experienced shortness of breath 10 days before admission and went to a local hospital. The chest non-contrast CT and Echo revealed effusion of pericardium, right thoracic cavity and abdominal cavity. The patient went to our hospital for further treatment, and there was no abnormality in the laboratory tests of infection, tumor, or immune disease...
September 27, 2018: Heart Surgery Forum
Tongyi Sun, Bo Zhan, Weifen Zhang, Di Qin, Guixue Xia, Huijie Zhang, Meiyu Peng, Sheng-An Li, Yun Zhang, Yuanyuan Gao, Wen-Hui Lee
Background: Nonscar wound healing is a desirable treatment for cutaneous wounds worldwide. Peptide OH-CATH30 (OH30) from king cobra can selectively regulate the innate immunity and create an anti-inflammatory micro-environment which might benefit nonscar wound healing. Purpose: To overcome the enzymatic digestion and control release of OH30, OH30 encapsulated in carboxymethyl chitosan nanoparticles (CMCS-OH30 NP) were prepared and their effects on wound healing were evaluated...
2018: International Journal of Nanomedicine
Eleine Weimann, Maysa Braga Barros Silva, Gilson Masahiro Murata, Jose Ricardo Bortolon, Alexandre Dermargos, Rui Curi, Elaine Hatanaka
This study investigated the effects of palmitoleic acid on different phases of the healing process. Macroscopic analyses were performed on wounds in rats with or without palmitoleic acid treatment, and the results showed that palmitoleic acid directly hastened wound closure. The topical treatment of wounds with palmitoleic acid resulted in smaller wounds than those observed in the control group. The anti-inflammatory activity of palmitoleic acid may be responsible for healing, especially in the stages of granulation tissue formation and remodelling...
2018: PloS One
Alison J May, Noel Cruz-Pacheco, Elaine Emmerson, Eliza A Gaylord, Kerstin Seidel, Sara Nathan, Marcus O Muench, Ophir Klein, Sarah M Knox
The ductal system of the salivary gland has long been postulated to be resistant to radiation-induced damage, a common side effect incurred by head and neck cancer patients receiving radiotherapy. Yet, whether the ducts are capable of regenerating after genotoxic injury, or if damage to ductal cells induces lineage plasticity, as has been reported in other organ systems, remains unknown. Here, we show that two ductal progenitor populations, marked exclusively by KRT14 and KIT, maintain non-overlapping ductal compartments after radiation exposure but do so through distinct cellular mechanisms...
October 10, 2018: Development
Xiao-Heng Xu, Si-Jin Zhang, Qi-Bo Hu, Xing-Yu Song, Wei Pan
Medulloblastoma (MB) is the most prevalent brain tumor that occurs during childhood and originates from cerebellar granule cell precursors. Based on recent studies, the differential expression of several microRNAs is involved in MB, while the role of microRNA-494 (miR-494) in MB remains unclear. Therefore, we conducted this study to investigate the regulative role of miR-494 in MB cells via the p38 mitogen-activated protein kinase (MAPK) signaling pathway by mediating c-myc. In the current study, MB cells were collected and transfected with miR-494 mimic, miR-494 inhibitor, siRNA- c-myc, and miR-494 inhibitor + siRNA-c-myc...
October 10, 2018: Journal of Cellular Biochemistry
Andrew Daugherty, Jason Susong
No abstract text is available yet for this article.
October 2018: JAAD Case Reports
Priyatam Khadka, Dibya Singh Shah
Background: The cutaneous nocardiosis remains a diagnostic challenge: similar clinical presentations as of cutaneous diseases with different etiology-and the inherent difficulty in cultivating the pathogen. Case presentation: Herein, we describe a case of primary cutaneous nocardiosis in a renal transplant recipient; treated with anti-tubercular drugs due to misdiagnosis of cutaneous tuberculosis. On clinical examinations, a few red erythematous papules with erosions and crusting seen, over prior surgery scar of renal transplant...
2018: BMC Clinical Pathology
Zhigang He, Yue Li, Sunqiang Ma, Muqing Yang, Yuanyuan Ma, Cheng Ma, Jian Song, Tianyu Yu, Siqi Zhang, Jiyu Li
The pathological changes following liver damage, including those caused by ischemia and reperfusion (I/R), are closely related to gastrointestinal dysregulation. Mast cells (MCs) are tissue-resident immune cells abundant in the gastrointestinal system that play diverse roles. In view of the characteristic localization of MCs around the microvasculature, we hypothesized that a stimulus-specific set of mediators released through degranulation of gastrointestinal MCs, which are enriched in hepatic sinusoids via the hepatic system, subsequently participate in associated pathological development within the liver...
October 9, 2018: Clinical Science (1979-)
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