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granulation tissue

Wasim Sajjad, Taous Khan, Mazhar Ul-Islam, Romana Khan, Zohaib Hussain, Ayesha Khalid, Fazli Wahid
Bacterial cellulose (BC) is a promising biopolymer with wound healing and tissue regenerative properties but lack of antimicrobial property limits its biomedical applications. Therefore, current study was proposed to combine wound healing property of BC with antimicrobial activity of montmorillonite (MMT) and modified montmorillonites (Cu-MMT, Na-MMT and Ca-MMT) to design novel artificial substitute for burns. Designed nanocomposites were characterized through Fe-SEM, FTIR and XRD. The antimicrobial activities of composites were tested against Escherichia coli, Salmonella typhimurium, Citrobacter fruendii, Pseudomonas aeruginosa, Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus...
February 15, 2019: Carbohydrate Polymers
Yun-Yan Hsu, Kuan-Lin Liu, Hsun-Hua Yeh, Hong-Ru Lin, Hua-Lin Wu, Jui-Chen Tsai
Thrombomodulin (TM) is a type-I transmembrane glycoprotein expressed on the surfaces of endothelial cells and epidermal keratinocytes. It is known to regulate blood coagulation, inflammation, and cell-cell adhesion. A recombinant TM, which contains an epidermal growth factor - like domain and serine/threonine-riches domain, has been demonstrated to stimulate cell proliferation and migration of keratinocytes and wound healing. In this study, we developed the biodegradable hydrogels and evaluated the efficacy of sustained release of rhTM from the hydrogel for the treatment of diabetic wounds...
December 12, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Natalya A Uranova, Olga V Vikhreva, Valentina I Rakhmanova, Diana D Orlovskaya
Microglial activation has been proposed to be involved in the pathophysiology of schizophrenia (SCZ). We hypothesized that dystrophic alterations of oligodendrocytes previously reported in the prefrontal white matter in SCZ might be associated with microglial activation in the acute state of SCZ. White matter of the prefrontal cortex (BA10) was studied in post-mortem brain tissue from 21 SCZ cases and 20 normal controls. The SCZ group included 12 subjects with predominantly positive symptoms and 9 subjects with predominantly negative symptoms...
December 13, 2018: NPJ Schizophrenia
Karl-Bernd Hüttenbrink
PURPOSE: The thesis that cholesteatoma evolves from a retraction pocket is widely accepted today. Yet, its prime etiology, the question of what triggers the invagination of healthy skin, still remains unclear despite centuries of investigations into the origin of cholesteatoma. A new idea interprets the horizontal migration of skin into the middle ear cavities as a self-healing process, curing an underlying inflammation in the tympanic cavity, through the overgrowth and contact with immunologically active tissue...
December 12, 2018: European Archives of Oto-rhino-laryngology
Hiroyuki Goda, Tomohiro Hamakawa, Koh-Ichi Nakashiro
Orocutaneous fistulas are one of the most problematic postoperative complications after oral cancer surgery. Notably, in patients with mandibular plate exposure it is necessary to remove the plate. However, it takes longer for these patients to achieve complete fistula closure. The present report described an 84-year-old man with a postoperative orocutaneous fistula and exposed mandibular plate who was treated with the vacuum-assisted closure system. This system protects the wound from contamination while the negative pressure prevents tissue fluid retention, promotes blood flow, facilitates granulation tissue formation and decreases the bacterial cell count...
December 2018: Experimental and Therapeutic Medicine
Lucile Sautier, David Guillier, Margaux Coste, Jean-Luc Servely, Charly Pignon, Eve Laloy, Thomas M Donnelly
An 8-y-old, intact female degu ( Octodon degus) was presented with a slow-growing mass on the tail tip. The mass was completely removed by partial caudectomy. Histologically, the last coccygeal vertebra was replaced by a lobulated neoplasm composed of large clear polygonal cells embedded in a myxoid alcian blue-positive matrix with highly vacuolated cytoplasm (physaliferous cells) and intracytoplasmic periodic acid-Schiff-positive granules. The neoplasm exhibited the morphologic features of a "classic" chordoma of humans, which is 1 of 3 distinct chordoma subtypes...
December 12, 2018: Journal of Veterinary Diagnostic Investigation
Bozkurt Kubilay Isik, Gökhan Gürses, Dilek Menziletoglu
Not only laymen but also dentists generally believe that extraction of acutely infected teeth should be avoided until the infection subdues by using systemic antibiotics. The aim of this study was to compare perioperative complications in routine extractions of acutely infected teeth with extractions of asymptomatic teeth. This prospective study was performed with 82 patients. Severe pain on percussion of the relevant tooth was considered as basic criteria for acute infection. The acutely infected teeth were labeled as the study group (n = 35) and the asymptomatic teeth as the control group (n = 47)...
December 6, 2018: Brazilian Oral Research
Carlos Eduardo da Silva, João Carlos Domingues Repka, Carlos José Franco de Souza, Jorge Eduardo Fouto Matias
BACKGROUND: Chronic kidney disease affects more than 500 million people worldwide. In this context, the uremic toxins present are related to worsening in tissue healing. AIM: Evaluate on healing of colonic anastomosis in uremic rats, serum and anatomopathological indicators, which may be related to the change tissue repair process. METHODS: Twenty Wistar rats, were randomly separated into two groups. In the sham group they were submitted to 5/6 nephrectomy simulation in left kidney, simulation right nephrectomy, median laparotomy, colotomy and colorraphy...
December 6, 2018: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Michelle Fonseca Costa, Aimée Obolari Durço, Thallita Kelly Rabelo, Rosana de Souza Siqueira Barreto, Adriana Gibara Guimarães
OBJECTIVES: The treatment of wounds accounts for a considerable fraction of health expenses as well as serious socioeconomic problems. The use of natural substances stands out as a source of new therapeutic discoveries for the wound healing. Thus, this review compiled scientific findings on the applicability of carvacrol and thymol, or essential oils containing at least one of these compounds, for the treatment of wounds. METHODS: This review was performed at PubMed, SCOPUS, Web of Science databases using keywords as wound healing, thymol/carvacrol and essential oils...
December 7, 2018: Journal of Pharmacy and Pharmacology
Ciro De Luca, Anna Maria Colangelo, Lilia Alberghina, Michele Papa
Coagulation and the immune system interact in several physiological and pathological conditions, including tissue repair, host defense, and homeostatic maintenance. This network plays a key role in diseases of the central nervous system (CNS) by involving several cells (CNS resident cells, platelets, endothelium, and leukocytes) and molecular pathways (protease activity, complement factors, platelet granule content). Endothelial damage prompts platelet activation and the coagulation cascade as the first physiological step to support the rescue of damaged tissues, a flawed rescuing system ultimately producing neuroinflammation...
2018: Frontiers in Cellular Neuroscience
Haiyan An, Non G Williams, Tatyana A Shelkovnikova
Neurodegenerative diseases are among the most common causes of disability worldwide. Although neurodegenerative diseases are heterogeneous in both their clinical features and the underlying physiology, they are all characterised by progressive loss of specific neuronal populations. Recent experimental evidence suggests that long non-coding RNAs (lncRNAs) play important roles in the CNS in health and disease. Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) is an abundant, ubiquitously expressed lncRNA, which forms a scaffold for a specific RNA granule in the nucleus, or nuclear body, the paraspeckle...
December 2018: Non-Coding RNA Research
Paola Tosi, Jibin He, Alison Lovegrove, Irene Gonzáles-Thuillier, Simon Penson, Peter R Shewry
Background: Wheat is the major food grain consumed in temperate countries. Most wheat is consumed after milling to produce white flour, which corresponds to the endosperm storage tissue of the grain. Because the starchy endosperm accounts for about 80% of the grain dry weight, the miller aims to achieve flour yields approaching this value. Scope and approach: Bioimaging can be combined with biochemical analysis of fractions produced by sequential pearling of whole grains to determine the distributions of components within the endosperm tissue...
December 2018: Trends in Food Science & Technology
D González-de-Olano, I Álvarez-Twose
Mast cells (MCs) are a key structural and functional component of both the innate and the adaptive immune systems. They are involved in many different processes, but play a major role in the response to infections and in inflammatory reactions. In addition, MCs are the main effector cells in allergy. MC biology is far more complex than initially believed. Thus, MCs may act directly or indirectly against pathogens and show a wide variety of membrane receptors with the ability to activate cells in response to various stimuli...
December 2018: Journal of Investigational Allergology & Clinical Immunology
Keiichiro Tanaka, Hisashi Hashimoto, Takeyuki Misawa, Tadashi Akiba
BACKGROUND: Postoperative bowel adhesions may lead to various disorders, including abdominal pain, bowel obstruction, ischemia, and necrosis. In previous reports, a dose-dependent increase in bowel adhesions was observed in talc-treated animals in comparison with control animals. Although various methods have been devised to prevent peritoneal adhesions, each of these methods has advantages and disadvantages. In this study, we have attempted to reassess the effect of a carboxymethylcellulose (CMC) solution in the reduction of peritoneal adhesions induced by an intraperitoneal injection of a talc suspension in mice...
February 2019: Journal of Surgical Research
Sharon Claudia Notodihardjo, Naoki Morimoto, Natsuko Kakudo, Toshihito Mitsui, Tien Minh Le, Yasuhiko Tabata, Kenji Kusumoto
BACKGROUND: The efficacy of a gelatin hydrogel (GH) sheet impregnated with platelet-rich plasma in full-thickness wound healing has been reported. Human platelet lysate is another potential natural product for use in wound healing. The present study examined the effects of a GH sheet impregnated with concentrated freeze-dried platelet lysate on wound healing after storage for 9 mo. MATERIALS AND METHODS: Platelet concentrates were subjected to three freeze-thaw cycles and freeze-dried then preserved at 4°C...
February 2019: Journal of Surgical Research
Humberto Fenner Lyra Junior, Leonardo de Lucca Schiavon, Igor Kunze Rodrigues, Daniella Serafin Couto Vieira, Roberta de Paula Martins, Bruna Lenfers Turnes, Alexandra Susana Latini, Armando José D'Acâmpora
BACKGROUND: Anastomotic leakage is the deadliest complication of colonic procedures. Ghrelin is an orexigenic hormone with potent actions on growth hormone release and functions in the processes of growth, tissue inflammation, repair, and oxidative stress. We evaluated the hypothesis that the exogenous administration of ghrelin causes beneficial effects on the healing of colonic anastomosis. MATERIALS AND METHODS: Sixty-four male Wistar rats were randomly assigned to eight subgroups receiving postoperative intraperitoneal administration of ghrelin (23 μg/kg/d) or saline after a colonic anastomosis...
February 2019: Journal of Surgical Research
Takanori Iwata, Masayuki Yamato, Kaoru Washio, Toshiyuki Yoshida, Yuka Tsumanuma, Azusa Yamada, Satoru Onizuka, Yuichi Izumi, Tomohiro Ando, Teruo Okano, Isao Ishikawa
Background: Periodontitis results in the destruction of tooth-supporting periodontal tissues and does not have the ability to heal spontaneously. Various approaches have been introduced to regenerate periodontal tissues; however, these approaches have limited efficacy for treating severe defects. Cytotherapies combine stem cell biology and tissue engineering to form a promising approach for overcoming these limitations. In this study, we isolated periodontal ligament (PDL)-derived cells from patients and created cell sheets with "Cell Sheet Engineering Technology", using temperature responsive culture dishes, in which all the cultured cells can be harvested as an intact transplantable cell sheet by reducing the temperature of the culture dish...
December 2018: Regenerative Therapy
Sharon Claudia Notodihardjo, Naoki Morimoto, Natsuko Kakudo, Toshihito Mitsui, Tien Minh Le, Yasuhiko Tabata, Kenji Kusumoto
Introduction: Human platelet lysate (hPL) part of the growth factor cocktail derived from human platelets, which has been applied as a cell growth supplement. The production process is easier in comparison to platelet-rich plasma; thus, hPL is now considered for use in wound healing therapy. However, methods for preserving hPL for more than several months that maintain its bioactivity must be considered, especially for chronic wound treatment. The present study compared the effects of preservation for 9 months using a refrigerator or deep freezer...
June 2019: Regenerative therapy
Samantha Ellis, Elaine J Lin, Danielle Tartar
Purpose of Review: Chronic wounds are a tremendous burden on the healthcare system and lead to significant patient morbidity and mortality. Normal cutaneous wound healing occurs through an intricate and delicate interplay between the immune system, keratinocytes, and dermal cells. Each cell type contributes signals that drive the normal phases of wound healing: hemostasis, inflammation, proliferation, and remodeling. This paper reviews how various immunological cell types and signaling molecules influence the way wounds develop, persist, and heal...
2018: Current Dermatology Reports
Michael Thorpe, Zhirong Fu, Emanuelle Albat, Srinivas Akula, Lawrence de Garavilla, Jukka Kervinen, Lars Hellman
Serine proteases constitute the major protein content of mast cell secretory granules. Here we present the extended cleavage specificity of two such proteases from the golden hamster, Mesocricetus auratus. Analysis by phage display technique showed that one of them (HAM1) is a classical chymase with a specificity similar to the human mast cell chymase. However, in contrast to the human chymase, it does not seem to have a particular preference for any of the three aromatic amino acids, Phe, Tyr and Trp, in the P1 position of substrates...
2018: PloS One
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