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acute STEMI

Giovanni Malanchini, Giulio Giuseppe Stefanini, Margherita Malanchini, Federico Lombardi
AIMS: An increased mortality risk during weekend hospital admission has been consistently observed. In the present study, we evaluated whether the current improvement in management of acute coronary syndromes (ACS) has reduced this phenomenon. METHODS AND RESULTS: We extracted data from the Italian National Healthcare System Databank of 80 391 ACS admissions in the region of Lombardia between 2010 and 2014. ICD-9 codes were used to assess the diagnosis. We performed a multiple logistic regression analysis to compare the mortality rates between weekend and weekday admissions...
December 11, 2018: Journal of Cardiovascular Medicine
Junhua Ge, Jian Li, Haichu Yu, Bo Hou
Background: Risk factors of multivessel coronary artery disease (CAD) among young acute coronary syndrome (ACS) patients remain elusive now. Methods: This retrospective study analyzed data from 187 consecutive young (age ≤45 years) ACS patients (75 STEMI, 30 NSTEMI, and 72 unstable angina) hospitalized in our hospital from January 2012 to December 2016. Thirty-six young male patients with normal coronary angiography (CAG) findings (no-CAD), who underwent CAG due to suspected chest pain in this period, served as control group...
2018: International Journal of Hypertension
Etienne Puymirat, Marc Bonaca, Maxime Fumery, Victoria Tea, Nadia Aissaoui, Gilles Lemesles, Laurent Bonello, Grégory Ducrocq, Guillaume Cayla, Jean Ferrières, François Schiele, Tabassome Simon, Nicolas Danchin
BACKGROUND: Guidelines recommend using risk stratification tools in acute myocardial infarction (AMI) to assist decision making. The TIMI Risk Score for Secondary Prevention (TRS-2P) has been recently developed to characterize long term risk in patients with MI. HYPOTHESIS: We aimed to assess the TRS-2P in the FAST-MI registries. METHODS: We used data from 3 one-month French registries, conducted 5 years apart, from 2005 to 2015, including 13,130 patients with AMI (52% ST-elevation myocardial infarction (STEMI))...
December 7, 2018: Clinical Cardiology
C-Q Miao, Q Lu, P Liu, L Bai, H Qu, A-Q Ma
OBJECTIVE: Nardilysin (N-arginine dibasic convertase, NRDC) is a kind of metalloendopeptidase associated with several inflammatory diseases. NRDC is reported to be eligible for early detection of acute coronary syndrome. However, the availability and effectiveness of NRDC in predicting the prognosis of patients with ST-elevation myocardial infarction has never been investigated. PATIENTS AND METHODS: From January 2010 to January 2012, the prospective observational cohort study enrolled a total of 396 STEMI patients, who were sampled with blood within 24 hours after admission...
November 2018: European Review for Medical and Pharmacological Sciences
Mohamed Hasham Varwani, Mohamed Jeilan, Mzee Ngunga, Anders Barasa
BACKGROUND: Coronary artery disease and its acute presentation are being increasingly recognised and treated in sub-Saharan Africa. It is just over a decade since the introduction of interventional cardiology for coronary artery disease in Kenya. Local and regional data, and indeed data from sub-Saharan Africa on long-term outcomes of acute coronary syndromes (ACS) are lacking. METHODS: A retrospective review of all ACS admissions to the Aga Khan University Hospital, Nairobi (AKUHN) between January 2012 and December 2013 was carried out to obtain data on patient characteristics, treatment and in-patient outcomes...
December 4, 2018: Cardiovascular Journal of Africa
Shuo-Lin Liu, Na-Qiong Wu, Meng Zhang, Jing-Lu Jin, Bing-Yang Zhou, Qian Dong, Jian-Jun Li
Objective: To investigate whether invasive strategy was associated with lower mortality in Chinese patients ≥ 80 years with acute myocardial infarction (AMI). Methods: We used retrospective data from our center between 2013 and 2017. During a median of 17.4 (interquartile range: 7.3-32.3) months follow-up, 120 deaths were recorded among 514 consecutive patients ≥ 80 years with AMI. The patients were divided into two groups: invasive treatment group (IT group, n = 269) and conservative treatment group (CT group, n = 245), which were also then compared with propensity score matching...
November 2018: Journal of Geriatric Cardiology: JGC
Pramod Theetha Kariyanna, Amog Jayarangaiah, Apoorva Jayarangaiah, Sudhanva Hegde, Jonathan D Marmur, Syed Haseeb, Teresa Song, Navneet Singh, Samy I McFarlane
Coronary air embolism (CARE) is a rare complication during transluminal coronary angiography or angioplasty and is almost always iatrogenic. CARE can cause significant morbidity and mortality as shown in animal studies. CARE is known to cause acute chest pain, hypotension, bradycardia, ST-segment elevation myocardial infarction (STEMI), and death. Multiple isolated case reports of CARE have been reported. We here present a systematic review of cases of CARE during transluminal coronary angiography or angioplasty...
2018: SciFed journal of cardiology
Wolfgang Ries, Ahmed Sheriff, Franz Heigl, Oliver Zimmermann, Christoph D Garlichs, Jan Torzewski
C-reactive protein (CRP) may be causative in cardiovascular disease. As yet, no specific CRP inhibitor for human application has been described. A 69-year-old male was referred with ST segment elevation myocardial infarction (STEMI). Typical symptoms of chest pain started at 10.00 p.m. The patient was admitted to the hospital at 1.30 a.m. the next day. As ECG showed anterior wall myocardial infarction, the patient was immediately transferred to successful emergency angioplasty/drug-eluting- (DE-) stenting of the subtotally occluded left anterior descending artery...
2018: Case Reports in Cardiology
Jie Jiang, Yu-Jie Zhou, Jian-Jun Li, Jun-Bo Ge, Ying-Qing Feng, Yong Huo
Objective: Despite current standard of care, the overall lipid goal attainment rate for hyperlipidemia patients, especially those who have experienced acute coronary syndrome (ACS), is suboptimal, which predisposes them to a higher residual risk of atherothrombotic events. This study aimed to describe characteristics of Chinese patients who recently experienced an ACS event and were on lipid-lowering treatment, yet failing to reach targeted goal. Methods: A multicenter, cross-sectional study was conducted to recruit 2,034 Chinese patients who experienced an ACS (ST segment elevation myocardial infarction [STEMI], non-STEMI, or unstable angina) event within the past 4-40 weeks and were on statin treatment (>2 weeks) from March 2015 to December 2016...
2018: Therapeutics and Clinical Risk Management
Rashidi Springall-Del Villar, Jorge Arturo Ortega-Hernández, Luis Fernando Pérez, Fausto Sánchez-Muñoz, Julio César Arana Martínez, Héctor González-Pacheco, Rafael Bojalil
Background: Inflammation can be grouped into three phases: proinflammatory, anti-inflammatory, and resolution. The latter, mainly attributed to lipid mediators, is the most recently described, and has been studied little in coronary ischemic diseases. Objective: To evaluate 1) if acute coronary syndromes (ACS) manifest different circulating levels of resolution mediators compared with stable angina (SA); 2) if their concentrations are related to those of pro and anti-inflammatory mediators; and 3) if such concentrations are associated with the severity of the disease and the damage produced...
2018: Gaceta Médica de México
Yong Hoon Kim, Ae-Young Her, Myung Ho Jeong, Byeong-Keuk Kim, Seung-Yul Lee, Sung-Jin Hong, Dong-Ho Shin, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
BACKGROUND AND AIMS: We compared the clinical impact of renin-angiotensin system inhibitors (RASI) on long-term clinical outcomes between ST-segment elevation (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) after successful percutaneous coronary intervention (PCI) with drug eluting stents (DES) because of the paucity of published data. METHODS: A total of 24,960 acute myocardial infarction (AMI) patients who underwent PCI with DES and were prescribed the RASI were enrolled and divided into two groups, the STEMI group (n = 14,061) and the NSTEMI group (n = 10,899)...
November 27, 2018: Atherosclerosis
Robert K Laundon, Laszlo Littmann
Subarachnoid hemorrhage (SAH) is occasionally associated with the electrocardiographic (ECG) pattern of ST-segment elevation myocardial infarction (STEMI). Missing the true clinical diagnosis can result in inappropriate and harmful interventions. We report the case of a 40-year-old female who was found down. The ECG was diagnostic for acute lateral STEMI. Further analysis of the ECG showed marked prolongation of the QT interval and the "spiked helmet sign" (SHS). The patient was ruled out for myocardial infarction and a head CT demonstrated a massive SAH with acute hemorrhage into the ventricles...
November 28, 2018: Journal of Electrocardiology
Krzysztof Dyrbus, Mariusz Gasior, Piotr Desperak, Jolanta Nowak, Tadeusz Osadnik, Maciej Banach
Despite well-defined therapeutic low-density lipoprotein cholesterol (LDL-C) target in the highest-risk population, low percentage of patients is administered with intensive lipid-lowering therapy and achieves recommended levels. Therefore, based on the Hyperlipidaemia Therapy in tERtiary Cardiological cEnTer (TERCET) Registry data we investigated the characteristics of lipid profile and management of dyslipidemia in acute coronary syndrome (ACS) patients. 19,287 consecutive patients hospitalized between 2006 and 2016 have been included in the study...
December 6, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Zaixin Jiang, Ruoxi Zhang, Meng Sun, Qi Liu, Shuqing Wang, Wei Wang, Qi Zhao, Hui Zhang, Yu Wang, Jingbo Hou, Bo Yu
BACKGROUND: Patients with acute coronary syndrome show an inflammatory response that is known to affect platelet aggregation. We aimed to clarify the relationship between the inflammation severity and the effect of antiplatelet therapy after percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI). METHODS: This retrospective, single-center study included 203 patients with STEMI who underwent primary PCI and were stratified on the basis of the antiplatelet therapy on admission (clopidogrel vs ticagrelor)...
December 2018: Canadian Journal of Cardiology
M Hrebenyk, L Zelenenka, L Zoria, S Maslii
The clinical experience implies poor prognosis in women with myocardial infarction (MI). We performed a retrospective cohort study of 1395 patients - 987 (70,75%) men and 408 (29,25%) women) aged of 64,63±11,43 years with myocardial infarction and comorbidity hospitalized between 2010-2016. This study shows an increase of mortality in women with myocardial infarction during the last 4 years from 23,1% to 34,2%. We observed more frequent cases of non-STEMI (p=0,014) and recurrent myocardial infarction in females compared with males (р<0,0001)...
October 2018: Georgian Medical News
Lloyd Steele, James Palmer, Amelia Lloyd, James Fotheringham, Javaid Iqbal, Ever D Grech
BACKGROUND: Lower socioeconomic status (SES) has been associated with worse outcomes after acute myocardial infarction. Data for survival after ST-elevation myocardial infarction (STEMI) by SES in the current era of primary percutaneous coronary intervention (PCI) is more limited. METHODS: Data was collected for all patients with acute STEMI undergoing primary PCI at The South Yorkshire Cardiothoracic Centre, UK between 2009 and 2014. A Cox regression analysis was used to assess differences in survival by SES quartile (using an area-level measure)...
November 23, 2018: International Journal of Cardiology
Mojtaba Ziaee, Sina Mashayekhi, Samad Ghaffari, Javad Mahmoudi, Parvin Sarbakhsh, Alireza Garjani
We assessed the prognostic value of serum levels of endocan in patients with the acute coronary syndrome (ACS) through its correlation with the Thrombolysis in Myocardial Infarction (TIMI) risk score and compared the possible association with clinical outcomes. In this prospective cross-sectional study, we enrolled 320 patients with documented ST-segment elevation myocardial infarction (STEMI), non-STEMI (NSTEMI), or unstable angina (UA) who underwent diagnostic coronary angiography. Endocan was measured soon after admission in the emergency department...
December 4, 2018: Angiology
Aurélie Loyeau, Hakim Benamer, Sophie Bataille, Sarah Tepper, Thévy Boche, Lionel Lamhaut, Virginie Pirès, Benoit Simon, François Dupas, Lisa Weisslinger, Gaëlle Le Bail, Alexandre Allonneau, Jean-Michel Juliard, Yves Lambert, Frédéric Lapostolle
INTRODUCTION: Recent studies reported a decrease in the incidence of acute myocardial infarction. This favorable evolution does not extend to young women. The interaction between gender, risk factors and myocardial infarction incidence remains controversial. OBJECTIVE: To compare the evolution of the age pyramid of patients with ST-elevation myocardial infarction (STEMI) according to gender. METHODS: Data from patients with STEMI managed in pre-hospital settings prospectively collected in the greater Paris area...
December 3, 2018: Journal of Clinical Medicine
Caroline E Gebhard, Catherine Gebhard, Foued Maafi, Marie-Jeanne Bertrand, Barbara E Stähli, Monika Maredziak, Susan Bengs, Ahmed Haider, Zheng W Zhang, David C Smith, Hung Q Ly
BACKGROUND: Pre-hospital delays have been associated with poor outcomes in patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). It is currently unknown how environmental variables affect treatment delays in these patients. METHODS AND RESULTS: The association between environmental variables, time to treatment including transportation times and adverse in-hospital events was assessed in 1828 consecutive patients with STEMI undergoing primary PCI between 2010 and 2014 in the Montreal metropolitan area...
November 26, 2018: Science of the Total Environment
Asma Sriha Belguith, Kaouthar Beltaief, Mohamed Amine Msolli, Wahid Bouida, Hela Abroug, Manel Ben Fredj, Imen Zemni, Mohamed Habib Grissa, Hamdi Boubaker, Mohamed Hsairi, Samir Nouira
BACKGROUND: We aimed to describe diagnosed acute coronary syndrome (ACS) and its care management and outcomes in emergency departments (EDs) and to determine related cardiovascular risk factors (CVRFs). METHODS: We conducted a cross sectional multicenter study that included 1173 adults admitted to EDs for acute chest pain (ACP) in 2015 at 14 sites in Tunisia. Data included patients' baseline characteristics, diagnosis, treatment and output. RESULTS: ACS represented 49...
December 3, 2018: BMC Emergency Medicine
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