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acute STEMI

Jae Yoon Park, Wei Guo, Mohammed Al-Hijji, Abdallah El Sabbagh, Kebede H Begna, Thomas M Habermann, Thomas E Witzig, Bradley R Lewis, Amir Lerman, Joerg Herrmann
BACKGROUND: Cancer and cardiovascular diseases are the two leading causes of death in industrialized countries. Optimal management of life-threatening presentations of both of their diseases can pose significant challenges. The current study aimed to address the incidence, management, and outcome of acute coronary syndromes (ACS) in patients with active hematological malignancies. METHODS: This retrospective registry-based cohort study included adults with active leukemia or lymphoma who were hospitalized at Mayo Clinic Rochester from 01/01/2004 to 12/31/2014...
October 5, 2018: International Journal of Cardiology
Martin Kozel, Viktor Kočka, Libor Lisa, Tomáš Buděšínský, Petr Toušek
A higher rate of bioresorbable vascular scaffold (BVS) thrombosis has been observed after device implantation compared to implantation of permanent metallic stents in recently published studies. The mechanism of BVS thrombosis is currently under debate. To assess whether the immune-inflammatory response after BVS implantation is a potential trigger of BVS thrombosis. The PRAGUE-19 study was an academic study that enrolled consecutive patients with ST-segment elevation myocardial infarction (STEMI) with the intention to implant a BVS...
October 12, 2018: Heart and Vessels
Wojciech Wańha, Maksymilian Mielczarek, Grzegorz Smolka, Tomasz Roleder, Miłosz Jaguszewski, Dariusz Ciećwierz, Brunon Tomasiewicz, Piotr Kubler, Jarosław Gorol, Michał Chmielecki, Stanisław Bartuś, Eliano Pio Navarese, Michał Kasprzak, Adam Sukiennik, Jacek Kubica, Andrzej Lekston, Michał Hawranek, Krzysztof Reczuch, Marcin Gruchała, Andrzej Ochała, Wojciech Wojakowski
BACKGROUND: There is a paucity of data on left main (LM) percutaneous coronary intervention (PCI) therapy with dedicated DES platforms. The LM-STENTYS is a multicenter registry aimed at evaluating clinical outcome after PCI of LM performed with a self-apposing Stentys DES implantation. METHODS: The registry consists of 175 consecutive patients treated with Stentys DES implanted to LM. The primary endpoint was the composite of major adverse cardiac and cerebral events (MACCE) defined as cardiac death, myocardial infarction (MI), target lesion revascularization (TLR), and stroke assessed after 1 year...
October 11, 2018: Catheterization and Cardiovascular Interventions
Sean M Davidson, Sapna Arjun, Maryna V Basalay, Robert M Bell, Daniel I Bromage, Hans Erik Bøtker, Richard D Carr, John Cunningham, Arjun K Ghosh, Gerd Heusch, Borja Ibanez, Petra Kleinbongard, Sandrine Lecour, Helen Maddock, Michel Ovize, Malcolm Walker, Marlene Wiart, Derek M Yellon
Due to its poor capacity for regeneration, the heart is particularly sensitive to the loss of contractile cardiomyocytes. The onslaught of damage caused by ischaemia and reperfusion, occurring during an acute myocardial infarction and the subsequent reperfusion therapy, can wipe out upwards of a billion cardiomyocytes. A similar program of cell death can cause the irreversible loss of neurons in ischaemic stroke. Similar pathways of lethal cell injury can contribute to other pathologies such as left ventricular dysfunction and heart failure caused by cancer therapy...
October 11, 2018: Basic Research in Cardiology
Kyunghee Lim, Jeong Hoon Yang, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Sung-Ji Park, Young Bin Song
BACKGROUND: Mild hypothermia (32-35°C) during acute myocardial ischemia has been considered cardioprotective in animal studies. We sought to determine the association of between natural mild hypothermia and myocardial salvage as assessed by cardiac magnetic resonance imaging (CMR) in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI). METHODS: In 291 patients with STEMI, CMR was performed a median of 3 days after the index event...
September 2018: Journal of cardiovascular imaging
Xuewei Chang, Shouyan Zhang, Mingming Zhang, Hao Wang, Caifeng Fan, Yunfei Gu, Jinghan Wei, Chunguang Qiu
BACKGROUND: The aim of this study is to investigate the combined value of fT3 and GRACE risk score for cardiovascular prognosis in ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). METHODS: Three hundred and thirty eight patients with STEMI who received successful primary PCI were enrolled in our study. All patients underwent (33.5 ± 7.1) month's follow-up. Mace was defined as cardiac death and nonfatal myocardial infarction...
October 12, 2018: Lipids in Health and Disease
Yoav Preisler, Tomer Ziv-Baran, Ehud Chorin, Gilad Margolis, Shafik Khoury, Yacov Shacham
BACKGROUND: A positive family history (FHx+) of coronary artery disease (CAD) is a well-known risk factor for the development of coronary pathology in first-degree relatives. We sought to evaluate the association between FHx+ of CAD and clinical outcomes in patients presenting with a first ST-elevation myocardial infarction (STEMI). PATIENTS AND METHODS: A historical cohort study of all patients with a first STEMI, who were admitted to cardiac ICU between 2007 and 2016, was carried out...
October 10, 2018: Coronary Artery Disease
Per O Andersson, Sofia Sederholm Lawesson, Jan-Erik Karlsson, Staffan Nilsson, Ingela Thylén
BACKGROUND: The characteristics of patients with on-going myocardial infarction (MI) contacting the primary healthcare (PHC) centre before hospitalisation are not well known. Prompt diagnosis is crucial in patients with MI, but many patients delay seeking medical care. The aims of this study was to 1) describe background characteristics, symptoms, actions and delay times in patients contacting the PHC before hospitalisation when falling ill with an acute MI, 2) compare those patients with acute MI patients not contacting the PHC, and 3) explore factors associated with a PHC contact in acute MI patients...
October 10, 2018: BMC Family Practice
Krzysztof Ściborski, Wiktor Kuliczkowski, Bożena Karolko, Dawid Bednarczyk, Marcin Protasiewicz, Andrzej Mysiak, Marta Negrusz-Kawecka
Introduction YKL-40 is a protein released locally by inflammatory cells. Thus, it may constitute a biomarker of inflammatory conditions, such as atherosclerosis. Objectives To determine the YKL-40 level in patients with ischemic heart disease, and to analyze the correlation of this biomarker with the severity of coronary atherosclerosis. Patients and methods The study included 158 patients, among them 52 with stable ischemic heart disease and 67 with an acute coronary syndrome: ST elevation (STEMI) and non-ST elevation myocardial infarction (NSTEMI)...
October 10, 2018: Polish Archives of Internal Medicine
Enrico Fabris, Arnoud Van't Hof, Christian W Hamm, Frédéric Lapostolle, Jens Flensted Lassen, Shaun G Goodman, Jurriën M Ten Berg, Leonardo Bolognese, Angel Cequier, Mohamed Chettibi, Christopher J Hammett, Kurt Huber, Magnus Janzon, Béla Merkely, Robert F Storey, Uwe Zeymer, Warren J Cantor, Mathieu Kerneis, Abdourahmane Diallo, Eric Vicaut, Gilles Montalescot
OBJECTIVE: We investigated, in the contemporary era of ST-elevation myocardial infarction (STEMI) treatment, the influence of diabetes mellitus (DM) on cardiovascular outcomes, and whether pre-hospital administration of ticagrelor may affect these outcomes in a subgroup of STEMI patients with DM. BACKGROUND: DM patients have high platelet reactivity and a prothrombotic condition which highlight the importance of an effective antithrombotic regimen in this high-risk population...
October 9, 2018: Catheterization and Cardiovascular Interventions
Cheng-Han Lee, Ching-Chang Fang, Liang-Miin Tsai, Shu-Ting Gan, Sheng-Hsiang Lin, Yi-Heng Li
Most studies about the trends of acute myocardial infarction (AMI) were based on the data from Western countries. In recent years, little information is available from Asia since 2010. This study assessed the nationwide trends of AMI in Taiwan from 2009 to 2015. Using data from the Taiwan National Health Insurance Research Database, we identified 100,570 adult patients hospitalized for AMI from 2009 to 2015 and examined the temporal trends in the incidence of AMI. Overall, the age- and gender-adjusted incidence of AMI (per 100,000 persons) remained constant from 49...
September 13, 2018: American Journal of Cardiology
Perry Wengrofsky, Ghassan Mubarak, Ahmed Shim, Pramod Theetha Kariyanna, Adam Buzidkowski, Jacob Schwartz, Samy I McFarlane
Marijuana abuse is rapidly growing and currently it is the most coimnon drug of abuse in the United States due to increased legalization for recreational and medicinal use. Delta 9-tetrahydrocannibol, the main psychoactive compound in marijuana, acts via the endocannabinoid system to elicit various cardiovascular physiological effects, and has been associated with many adverse cardiovascular effects such as acute coronary syndrome, arrhythmias, and sudden cardiac death that have previously been reported by our group and others...
2018: American journal of medical case reports
Yavuz Karabağ, Metin Çağdaş, Ibrahim Rencuzogullari, Süleyman Karakoyun, İnanç Artaç, Doğan İliş, Mahmut Yesin, Handan Çiftçi, Halil Ibrahim Erdoğdu, Ibrahim Halil Tanboğa
BACKGROUND: The relationship between acute kidney injury (AKI) and C-reactive protein (CRP) and albumin has been previously demonstrated in patients with ST elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). However, to our knowledge, CRP to albumin ratio (CAR), a newly introduced inflammation-based risk score, has not yet been studied. In this study, we aimed to investigate the possible relationship between the CAR and AKI. METHOD: A total of 815 consecutive STEMI patients treated with pPCI were reviewed...
September 9, 2018: Heart, Lung & Circulation
Hugo Bernelin, Nathan Mewton, Salim Si-Mohamed, Pierre Croisille, Gilles Rioufol, Eric Bonnefoy-Cudraz, Philippe Douek, Nathalie Dufay, Camille Amaz, Claire Jossan, Michel Ovize, Thomas Bochaton
BACKGROUND: Several preliminary analyses suggested an association between neprilysin levels and myocardial infarction. HYPOTHESIS: The objective was to assess whether Neprilysin (NEP) plasma levels following reperfusion might be a surrogate for infarct size (IS) or predict adverse outcomes in acute ST-segment elevation myocardial infarction (STEMI) patients. METHODS: We measured NEP levels in a prospective cohort of 203 patients with STEMI referred for primary percutaneous coronary intervention...
October 3, 2018: Clinical Cardiology
Juliane Araujo Rodrigues, Karina Melleu, Márcia Moura Schmidt, Carlos Antonio Mascia Gottschall, Maria Antonieta Pereira de Moraes, Alexandre Schaan de Quadros
BACKGROUND: In patients with acute ST-segment elevation myocardial infarction (STEMI), the time elapsed from symptom onset to receiving medical care is one of the main mortality predictors. OBJECTIVE: To identify independent predictors of late presentation in patients STEMI representative of daily clinical practice. METHODS: All patients admitted with a diagnosis of STEMI in a reference center between December 2009 and November 2014 were evaluated and prospectively followed during hospitalization and for 30 days after discharge...
September 21, 2018: Arquivos Brasileiros de Cardiologia
Tomohiko C Umei, Toru Awaya, Osamu Okazaki, Hisao Hara, Yukio Hiroi
A 50-year-old man with a dual-chamber pacemaker was admitted to our hospital complaining of chest pain. Anterior ST segment elevation myocardial infarction (STEMI) was diagnosed. Emergency coronary angiography revealed total occlusion of the proximal left anterior descending artery (LAD), and primary percutaneous coronary intervention was performed. Angiograms showed that the LAD was wrapped around the apex of both ventricles. On day 8, ventricular fibrillation and cardiopulmonary arrest occurred due to elevation of the pacing threshold because of pacemaker malfunction...
July 2018: Journal of Cardiology Cases
Guo-Yong Liu, Xiao-Xue Meng, Zheng Zhang
To determine the prognostic role of triglyceride (TG) to high-density lipoprotein cholesterol (HDL) ratio for poorly developed coronary collateral circulation (CCC) in elderly patients with ST-segment elevation myocardial infarction (STEMI) and acute total occlusion (ATO).As a retrospective case-control study, elderly patients (age ≥60 years) with both STEMI and ATO (n = 346) were classified as having either poorly- or well-developed CCC (Rentrop grades 0-1 and 2-3, respectively). The ratio of TG/HDL was calculated according to the detected levels of TG and HDL...
September 2018: Medicine (Baltimore)
Ünal Güntekin, Veysel Tosun, Ali Yaşar Kilinç, Gündüzalp Saydam, Necmettin Korucuk, Mehmet Nuri Bozdemir
Statin nonadherence or discontinuation is associated with increased cardiovascular events. Many factors related to the physicians or the patients are influential in this. We aimed to compare the compliance with statin therapy between the patients who first presented with ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI), and unstable angina pectoris (UA) based on the target achievement according to the current dyslipidemia guidelines.We retrospectively acquired all the information about demographic characteristics, in-hospital revascularization procedures, prescribed treatments, and index and up to 6-month follow-up laboratory results of the first acute coronary syndrome patients...
September 2018: Medicine (Baltimore)
Rong Sun, Sining Hu, Giulio Guagliumi, Haibo Jia, Jinwei Tian, Lulu Li, Shaotao Zhang, Yini Wang, Shaosong Zhang, Jingbo Hou, Bo Yu
AIMS: This study aimed to evaluate the relationship between pre-infarction angina (PIA) and in vivo culprit lesion characteristics as assessed by intravascular optical coherence tomography (OCT) in patients with a first ST-segment elevation myocardial infarction (STEMI). METHODS AND RESULTS: A total of 305 consecutive patients with a first STEMI who underwent OCT imaging of culprit lesions during primary percutaneous coronary intervention (PCI) were prospectively enrolled...
October 2, 2018: EuroIntervention
S Pessinaba, Y D M Atti, K Yayehd, M B F Simwétaré, W Kaziga, Y M Afassinou, B Atta, M Pio, M Kpélafia, S Baragou, F Damorou
INTRODUCTION: The aim of this work was to describe the epidemiological, clinical, and therapeutic characteristics of acute coronary syndromes (ACS) in the cardiology department of Lome Campus University Hospital in Togo. METHODOLOGY: We conducted a prospective study that consistently included patients hospitalized from 2014 to 2017 for ACS, based on clinical, electrocardiographic, and laboratory findings. RESULTS: Of 1914 patients admitted to the department during the study period, 67 were admitted for ACS, for a 3...
August 1, 2018: Médecine et Santé Tropicales
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