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https://www.readbyqxmd.com/read/30115630/proteomic-discovery-and-validation-of-the-confounding-effect-of-heparin-administration-on-the-analysis-of-candidate-cardiovascular-biomarkers
#1
Hans C Beck, Lisette O Jensen, Charlotte Gils, Albertine M M Ilondo, Martin Frydland, Christian Hassager, Ole K Møller-Helgestad, Jacob E Møller, Lars M Rasmussen
BACKGROUND: Several plasma proteins have been suggested as markers for a variety of cardiovascular conditions but fail to qualify in independent patient cohorts. This may relate to interference of medication on plasma protein concentrations. We used proteomics to identify plasma proteins that changed in concentration with heparin administration and therefore potentially may confound their evaluation as biomarkers in situations in which heparin is used. METHODS: We used a proteomic approach based on isobaric tagging and nano-LC-MS/MS analysis to quantify several hundred proteins in a discovery study in which individual plasma samples from 9 patients at intravascular ultrasound follow-up 12 months after an acute myocardial infarction before heparin administration and 2, 15, and 60 min after heparin administration; we validated our findings in 500 individual plasma samples obtained at admission from patients with suspected ST segment elevation myocardial infarction (STEMI), of whom 363 were treated with heparin before admission...
August 16, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/30115422/bleeding-events-after-st-segment-elevation-myocardial-infarction-in-patients-randomized-to-an-all-comer-clinical-trial-compared-with-unselected-patients
#2
Golnaz Sadjadieh, Thomas Engstrøm, Dan Eik Høfsten, Steffen Helqvist, Lars Køber, Frants Pedersen, Peter Nørkjær Laursen, Hedvig Bille Andersson, Lars Nepper-Christensen, Peter Clemmensen, Rikke Sørensen, Erik Jørgensen, Kari Saunamäki, Hans-Henrik Tilsted, Henning Kelbæk, Lene Holmvang
Most studies reporting bleedings in patients with ST-segment elevation myocardial infarction (STEMI) are reports from clinical trials, which may be unrepresentative of incidences in real-life. In this study, we investigated 1-year bleeding and mortality incidences in an unselected STEMI population, and compared participants with nonparticipants of a randomized all-comer clinical trial (The Third DANish Study of Optimal Acute Treatment of Patients with STEMI (DANAMI-3)). Hospital charts were read and bleedings classified according to thrombolysis in myocardial infarction (TIMI) and Bleeding Academic Research Consortium (BARC) criteria in 2,490 consecutive STEMI patients who underwent primary percutaneous coronary intervention in a single, large, and tertiary heart center...
July 19, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/30112383/relationship-between-trail-and-left-ventricular-ejection-fraction-in-patients-with-st-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention
#3
Elena Teringova, Martin Kozel, Jiri Knot, Viktor Kocka, Klara Benesova, Petr Tousek
Background: Apoptosis plays an important role in the myocardial injury after acute myocardial infarction and in the subsequent development of heart failure. Aim: To clarify serum kinetics of apoptotic markers TRAIL and sFas and their relation to left ventricular ejection fraction (LVEF) in patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). Methods: In 101 patients with STEMI treated with pPCI, levels of TRAIL and sFas were measured in series of serum samples obtained during hospitalization and one month after STEMI...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30110686/whole-body-plethysmography-and-blood-gas-analysis-in-patients-with-acute-myocardial-infarction-undergoing-percutaneous-coronary-intervention
#4
Michael Dreher, Ayham Daher, András Keszei, Nikolaus Marx, Tobias Müller, Christian Cornelissen, Vincent Brandenburg
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD) often occur together. However, COPD is underdiagnosed among CHD patients. OBJECTIVES: This study investigated the prevalence of COPD and relevant pulmonary function test (PFT) impairments in patients with acute myocardial infarction (AMI). METHODS: Patients undergoing coronary angiography for AMI were prospectively included. Body plethysmography, lung diffusing capacity, blood gas analysis, and echocardiography were performed...
August 15, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/30107901/a-simplified-formula-discriminating-subtle-anterior-wall-myocardial-infarction-from-normal-variant-st-segment-elevation
#5
Emre Aslanger, Özlem Yıldırımtürk, Emrah Bozbeyoğlu, Barış Şimşek, Can Yücel Karabay, Ayça Türer Cabbar, Ömer Kozan, Muzaffer Değertekin
Benign variant (BV) ST-segment elevation (STE) is present in anterior chest leads in most individuals and may cause diagnostic confusion in patients presenting with chest pain. Recently, 2 regression formulas were proposed for differentiation of BV-STE from anterior ST-elevation myocardial infarction (MI) on the electrocardiogram, computation of which is heavily device-dependent. We hypothesized that a simpler visual-assessment-based formula, namely (R-wave amplitude in lead V4 + QRS amplitude in V2) - (QT interval in millimeters + STE60 in V3), will be noninferior to these formulas...
July 19, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/30100680/uncommon-cause-of-complicated-myocardial-infarction-with-normal-coronary-arteries-in-a-saudi-patient
#6
Ahmed Abuosa, Jamilah AlRahimi, Nasir Mansour, Ashar Bilal, Atif AlQabbani, Akram Neyaz
A case of a young Saudi patient with a previous diagnosis of bronchial asthma, nasal polyps, and chronic smoker, presented with atypical chest pain, elevated serum troponin and borderline ischemic electrocardiogram (ECG) changes, with no significant regional wall motion abnormalities at bedside echocardiography is reported. The patient was admitted to the coronary care unit for continuous monitoring as possible acute coronary syndrome, non-ST elevation myocardial infarction (STEMI). One hour after admission, the patient had ventricular fibrillation (VF) cardiac arrest that required three DC shocks and amiodarone bolus before returning of spontaneous circulation, which followed the fourth shock...
October 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/30098028/use-of-ticagrelor-alongside-fibrinolytic-therapy-in-patients-with-st-segment-elevation-myocardial-infarction-practical-perspectives-based-on-data-from-the-treat-study
#7
Otavio Berwanger, Magdy Abdelhamid, Thomas Alexander, Abdulmajeed Alzubaidi, Oleg Averkov, Philip Aylward, Eduardo Contreras Zúñiga, Sigrun Halvorsen, Ricardo Iglesias, Muhamad A Sk Abdul Kader, Mohammad Zubaid, Khalid F AlHabib
Primary percutaneous coronary intervention (PCI) is the preferred reperfusion method in patients with ST-segment elevation myocardial infarction (STEMI). In patients with STEMI who cannot undergo timely primary PCI, pharmacoinvasive treatment is recommended, comprising immediate fibrinolytic therapy with subsequent coronary angiography and rescue PCI if needed. Improving clinical outcomes following fibrinolysis remains of great importance for the many patients globally for whom rapid treatment with primary PCI is not possible...
August 11, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30092297/increased-branched-chain-amino-acid-levels-are-associated-with-long-term-adverse-cardiovascular-events-in-patients-with-stemi-and-acute-heart-failure
#8
Xiaoyu Du, Yulin Li, Yuan Wang, Hongzhao You, Peng Hui, Yang Zheng, Jie Du
AIMS: The long-term prognosis of ST-segment elevation myocardial infarction (STEMI) with acute heart failure (AHF) is poor. Identification of metabolic changes could provide understanding of the underlying pathological progress associated with adverse events in patients with STEMI and AHF. Therefore, the study aimed to identify new plasm metabolites associated with long-term adverse cardiovascular events in patients with STEMI and AHF. MATERIALS AND METHODS: Mass spectrometry measurements of 26 amino acids were performed in 138 patients with STEMI and AHF...
August 6, 2018: Life Sciences
https://www.readbyqxmd.com/read/30084493/left-ventricular-thrombosis-in-acute-anterior-myocardial-infarction-evaluation-of-hospital-mortality-thromboembolism-and-bleeding
#9
Pradhum Ram, Mahek Shah, Natee Sirinvaravong, Kevin Bryan Lo, Shantanu Patil, Brijesh Patel, Byomesh Tripathi, Lohit Garg, Vincent Figueredo
INTRODUCTION: Left ventricular thrombosis (LVT) is a well-known complication of acute myocardial infarction, most commonly seen in anterior wall ST-segment elevation myocardial infarction (STEMI). It is associated with systemic thromboembolism. HYPOTHESIS: Our aim was to evaluate the impact of LVT on in-hospital mortality, thromboembolism and bleeding in patients with anterior STEMI. METHODS: Data was collected from the Nationwide Inpatient Sample where patients with a primary diagnosis of 'Anterior STEMI' [ICD9-CM code 410...
August 7, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/30084185/endogenous-glp-1-system-response-is-impaired-during-st-elevation-myocardial-infarction-in-type-2-diabetes-patients
#10
Gabby Elbaz-Greener, Olga Bloch, Ilya Kumets, Alex Blatt, Micha J Rapoport
We previously demonstrated increased GLP-1 secretion during acute ST elevation myocardial infarction (STEMI) in non-diabetic (ND) patients. Whether the endogenous GLP-1 system response is different in patients with type 2 diabetes (T2D) during STEMI is unknown. Patients with STEMI (20 ND, 13 T2D) and three control groups: non-STEMI (14 ND,13 T2D), stable angina pectoris (SAP) (8 ND, 10 T2D) patients and healthy subjects (n=25) were studied. Plasma levels of total and active GLP-1 and soluble DPP-4 (sDPP4) were estimated by ELISA on admission and 24, 48 hours after percutaneous coronary intervention (PCI) in all patients...
August 6, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/30081658/sodium-nitrite-mediated-cardioprotection-in-primary-percutaneous-coronary-intervention-for-st-segment-elevation-myocardial-infarction-a-cost-effectiveness-analysis
#11
Daniel A Jones, Peter Whittaker, Krishnaraj S Rathod, Amy J Richards, Mervyn Andiapen, Sotiris Antoniou, Anthony Mathur, Amrita Ahluwalia
OBJECTIVES: In the follow-up of patients in a trial of intracoronary sodium nitrite given during primary percutaneous coronary intervention (PCI) after acute myocardial infarction (AMI), we found a reduction in the incidence of major adverse cardiac events (MACEs). Specifically, MACE rates were 5.2% versus 25.0% with placebo at 3 years ( P = .013). Such MACE reductions should also be associated with economic benefit. Thus, we assessed the cost utility of sodium nitrite therapy versus standard primary PCI only...
August 6, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/30080886/9-year-clinical-follow-up-of-patients-with-st-segment-elevation-myocardial-infarction-with-genous-or-taxus-libert%C3%A3-stents
#12
Georgiana-Aura Giurgea, Andrea Heuberger, Jamil Babayev, Susanne Winkler, Oliver Schlager, Irene M Lang, Mariann Gyöngyösi
OBJECTIVES: This matched-cohort retrospective study investigated the long-term (9-year) safety and efficacy outcomes of patients with ST-segment elevation myocardial infarction (STEMI) and primary percutaneous coronary intervention (pPCI) with Genous (n = 102) versus TAXUS Liberté (n = 101) stents in 2006-2008. BACKGROUND: In the era of off-label use of drug-eluting stents for pPCI in patients with STEMI, the use of first-generation Genous stents (endothelial progenitor cell capture stents that have a passive coating and accelerate re-endothelialization) was proposed...
2018: PloS One
https://www.readbyqxmd.com/read/30075324/impact-of-total-ischemic-time-on-manual-thrombus-aspiration-benefit-during-primary-percutaneous-coronary-intervention
#13
Sarah Hugelshofer, Marco Roffi, Fabienne Witassek, Franz R Eberli, Thomas Pilgrim, Giovanni Pedrazzini, Hans Rickli, Dragana Radovanovic, Paul Erne, Sophie Degrauwe, Olivier Muller, Pier Giorgio Masci, Stephan Windecker, Juan F Iglesias
BACKGROUND: The benefits of manual thrombus aspiration (TA) during primary percutaneous coronary intervention (pPCI) for ST-elevation myocardial infarction (STEMI) remain uncertain. We assessed the influence of total ischemic time (TIT) on clinical outcomes among STEMI patients undergoing manual TA during pPCI. METHODS AND RESULTS: We conducted a retrospective study of patients enrolled in the Acute Myocardial Infarction in Switzerland Plus registry. STEMI patients undergoing pPCI with (TA group) or without (PCI-alone group) manual TA were stratified based on short (<3 hours), intermediate (3-6 hours), and long (>6 hours) TIT...
July 10, 2018: American Heart Journal
https://www.readbyqxmd.com/read/30074197/prognostic-value-of-neutrophil-to-lymphocyte-ratio-for-in-hospital-mortality-in-elderly-patients-with-acute-myocardial-infarction
#14
Tang-Meng Guo, Bei Cheng, Li Ke, Si-Ming Guan, Ben-Ling Qi, Wen-Zhu Li, Bin Yang
Coronary artery disease (CAD) is a multifactorial disease in which inflammation plays a central role. This study aimed to investigate the association of inflammatory markers such as the neutrophil to lymphocyte ratio (NLR), the Global Registry of Acute Coronary Events (GRACE) score with in-hospital mortality of elderly patients with acute myocardial infarction (AMI) in an attempt to explore the prognostic value of these indices for elderly AMI patients. One thousand consecutive CAD patients were divided into two groups based on age 60...
April 2018: Current medical science
https://www.readbyqxmd.com/read/30073720/predictors-of-myocardial-functional-recovery-following-successful-reperfusion-of-acute-st-elevation-myocardial-infarction
#15
Islam ElSayed Shehata, Cheng-I Cheng, Pei-Hsun Sung, Ahmed S Ammar, Islam Abd El-Moneem El-Sherbiny, Islam Ghanem Ahmed Ghanem
BACKGROUND: Following acute ST elevation myocardial infarction (STEMI), restoration of large-vessel patency does not mean complete perfusion recovery. Little is known regarding the predictors of successful myocardial reperfusion for the STEMI patients undergoing pharmacologic and mechanical reperfusion strategies. AIM OF THE WORK: The aim of this clinical study was to find out the predictors of myocardial functional recovery following reperfusion of acute STEMI, represented by 3-month global longitudinal strain (GLS) value assessed by speckle tracking echocardiography...
August 2, 2018: Echocardiography
https://www.readbyqxmd.com/read/30067392/circadian-and-seasonal-variations-in-patients-with-acute-stemi-a-retrospective-single-ppci-center-study
#16
Napohn Chongprasertpon, John Joseph Coughlan, Ciara Cahill, Thomas John Kiernan
This was a retrospective observational analysis of all (n = 876) ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PPCI) at University Hospital Limerick (UHL) from 2012 to 2016 to determine whether chronological patterns existed in incidence and mortality at our center. Data were obtained from the electronic Cardiology STEMI database in UHL. Statistical analysis was performed using the Independent Samples t Test, ANOVA and Pearson's Chi-Squared test...
August 1, 2018: Chronobiology International
https://www.readbyqxmd.com/read/30057807/-mif-mrna-expression-and-soluble-levels-in-acute-coronary-syndrome
#17
Emmanuel Valdés-Alvarado, Yeminia Valle, José Francisco Muñoz-Valle, Ilian Janet García-Gonzalez, Angelica Valdez-Haro, Hector Enrique Flores-Salinas, Jorge Manuel Pérez-Ibarra, Elena Sandoval-Pinto, Jorge Ramón Padilla-Gutiérrez
Acute coronary syndrome (ACS) describes any condition characterized by myocardial ischaemia and reduction in blood flow. The physiopathological process of ACS is the atherosclerosis where MIF operates as a major regulator of inflammation. The aim of this study was to assess the mRNA expression of MIF gene and its serum levels in the clinical manifestations of ACS and unrelated individuals age- and sex-matched with patients as the control group (CG). All samples were run using the conditions indicated in TaqMan Gene Expression Assay protocol...
2018: Cardiology Research and Practice
https://www.readbyqxmd.com/read/30054712/the-german-cpu-registry-comparison-of-smokers-and-nonsmokers
#18
D Bock, J Senges, C Pohlmann, M Hochadel, T Münzel, E Giannitsis, C Schmitt, G Heusch, T Voigtländer, H Mudra, B Schumacher, H Darius, L S Maier, B Hailer, M Haude, H Gohlke, U Hink
BACKGROUND: Chest pain is a major reason for admission to an internal emergency department, and smoking is a well-known risk factor for coronary artery disease (CAD) and acute coronary syndrome (ACS). The aim of this analysis is to illustrate the differences between smokers and nonsmokers presenting to German chest pain units (CPU) in regard to patient characteristics, CAD manifestation, treatment strategy, and prognosis. METHODS: From December 2008 to March 2014, 13,902 patients who had a complete 3‑month follow-up were enrolled in the German CPU registry...
July 27, 2018: Herz
https://www.readbyqxmd.com/read/30046467/the-utility-of-point-of-care-test-for-soluble-st2-in-predicting-adverse-cardiac-events-during-acute-care-of-st-segment-elevation-myocardial-infarction
#19
Anggoro Budi Hartopo, Indah Sukmasari, Ira Puspitawati
Introduction: Soluble ST2 (sST2) is increased during acute myocardial infarction. The point of care test (POCT) for sST2 is currently available. The aim of this study was to investigate the utility of the sST2 POCT measurement for predicting adverse cardiac events during acute care of ST-elevation myocardial infarction (STEMI). Patients and Methods: This research used a cohort study design. Consecutive patients with STEMI were enrolled. Soluble ST2 level was measured from peripheral blood taken on admission with POCT...
2018: Cardiology Research and Practice
https://www.readbyqxmd.com/read/30045300/clinical-associations-of-microvascular-obstruction-and-intramyocardial-hemorrhage-on-cardiovascular-magnetic-resonance-in-patients-with-acute-st-segment-elevation-myocardial-infarction-stemi-an-observational-cohort-study
#20
Min Ma, Kai-Yue Diao, Zhi-Gang Yang, Ye Zhu, Ying-Kun Guo, Meng-Xi Yang, Yi Zhang, Yong He
Acute myocardial infarction (AMI) is recognized as being a life-threatening event. Both microvascular obstruction (MVO) and intramyocardial hemorrhage (IMH) have been recognized as poor prognostic factors in myocardial infarct (MI) since they adversely affect left ventricular remodeling. MVO refers to small vessels changes that prevent adequate tissue perfusion despite revascularization whereas IMH is a severe form of MVO. A limited number of studies have demonstrated the segmental intervention time and the clinical factors in the presence of MVO and IMH...
July 2018: Medicine (Baltimore)
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