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cost analysis of capecitabine versus fluorouracil

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https://www.readbyqxmd.com/read/29600384/paclitaxel-as-albumin-bound-nanoparticles-with-gemcitabine-for-untreated-metastatic-pancreatic-cancer-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#1
REVIEW
Angela Stainthorpe, Janette Greenhalgh, Adrian Bagust, Marty Richardson, Angela Boland, Sophie Beale, Rui Duarte, Eleanor Kotas, Lindsay Banks, Daniel Palmer
As part of the single technology appraisal (STA) process, the National Institute for Health and Care Excellence (NICE) invited Celgene Ltd to submit clinical and cost-effectiveness evidence for paclitaxel as albumin-bound nanoparticles (Nab-Pac) in combination with gemcitabine (Nab-Pac + Gem) for patients with untreated metastatic pancreatic cancer. The STA was a review of NICE's 2015 guidance (TA360) in which Nab-Pac + Gem was not recommended for patients with untreated metastatic pancreatic cancer...
October 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/28277030/cost-minimization-analysis-of-capecitabine-versus-5-fluorouracil-based-treatment-for-gastric-cancer-patients-in-hong-kong
#2
Keary R Zhou, Ashley Cheng, W T Ng, T Y Kwok, Elton Y P Yip, Rosa Yao, P Y Leung, V W Y Lee
BACKGROUND: EOX (epirubicin, oxaliplatin, Xeloda; capecitabine) and FOLFOX4 (5-fluorouracil (5-FU), leucovorin, oxaliplatin) are the common chemotherapy regimens used in the treatment of advanced gastric cancer (aGC) in Hong Kong. This study aimed to compare the costs of these therapies for aGC patients from both the healthcare and societal perspectives. It should be noted that, while FOLFOX4 is routinely administered in an outpatient setting in North America and Europe, inpatient setting is adopted in Hong Kong instead, incurring hospitalization cost as a result...
May 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/27824060/cost-effectiveness-analysis-of-fluorouracil-leucovorin-and-irinotecan-versus-epirubicin-cisplatin-and-capecitabine-in-patients-with-advanced-gastric-adenocarcinoma
#3
Feng Wen, Hanrui Zheng, Yifan Wu, John Wheeler, Xiaoxi Zeng, Ping Fu, Qiu Li
No standard treatment has been accepted widely for the first-/second-line therapy for advanced gastric cancer (AGC). The current study aimed to determine a preferred strategy between FOLFIRI (fluorouracil, leucovorin, and irinotecan) and ECX (epirubicin, cisplatin,and capecitabine) for AGC from the cost-effectiveness perspective. According to a French intergroup study, two groups (ECX arm and FOLFIRI arm) and three health states (progression-free survival (PFS), progressive disease (PD) and death) were analyzed in the current Markov model...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26524925/population-based-cost-minimization-analysis-of-capox-versus-modified-folfox6-in-the-adjuvant-treatment-of-stage-iii-colon-cancer
#4
Maria Y Ho, Albert Y Chang, Jenny Y Ruan, Winson Y Cheung
BACKGROUND: Evidence suggests that CAPOX (capecitabine and oxaliplatin) has efficacy similar to 5-fluorouracil and oxaliplatin (mFOLFOX6) in the adjuvant treatment of colon cancer. CAPOX is partly administered orally and associated with a 3-week rather than a 2-week treatment cycle. A population-based cost-minimization analysis was conducted from the health care payer and societal perspectives to evaluate the potential cost savings of replacing mFOLFOX6 with CAPOX. METHODS: We applied treatment and toxicity data from phase III trials of CAPOX and FOLFOX-based regimens to the adjuvant colon cancer population in British Columbia, Canada...
June 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/25986478/comparing-the-effectiveness-of-capecitabine-versus-5-fluorouracil-leucovorin-therapy-for-elderly-taiwanese-stage-iii-colorectal-cancer-patients-based-on-quality-of-life-measures-qlq-c30-and-qlq-cr38-and-a-new-cost-assessment-tool
#5
COMPARATIVE STUDY
Jen-Kou Lin, Elise Chia-Hui Tan, Ming-Chin Yang
BACKGROUND: Colorectal cancer (CRC) is a leading cause of cancer-related deaths in developed countries and its incidence increases with age. Intravenous administration of bolus 5-fluorouracil (5-FU) and leucovorin (LV) has been a standard treatment regime for stage III CRC. However, patients generally prefer oral therapy such as Capecitabine. Studies showed that combination of oxaliplatin and capecitabine demonstrated efficacy and safety on par with treatment involving various 5-FU/LV-based regimens in elderly patients as they are in younger ones...
2015: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/25099199/health-related-quality-of-life-and-cost-comparison-of-adjuvant-capecitabine-versus-5-fluorouracil-leucovorin-in-stage-iii-colorectal-cancer-patients
#6
MULTICENTER STUDY
Hong-Hwa Chen, William Tzu-Liang Chen, Hsin-Chung Lee, Jen-Kou Lin, Chuan-Yin Fang, Yenn-Hwei Chou, Peng-Chan Lin, Bo-Wen Lin, Chi-Chou Huang, Chung-Hung Yeh, Hsi-Hsien Hsu, Hung-Chang Chen, Wen-Chien Ting, Ming-Chin Yang, Elise Chia-Hui Tan
PURPOSE: The purpose of this study was to compare health-related quality of life (HRQoL) and costs associated with 2 adjuvant chemotherapy regimens [capecitabine-based therapy versus 5-fluorouracil/leucovorin (5-FU/LV)-based therapy] in stage III colorectal cancer patients. METHODS: We conducted a prospective, open-label, observational, multicenter study from July 2008 to July 2011. The European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-CR38 questionnaires was used to assess HRQoL before, during, and after treatment...
February 2015: Quality of Life Research
https://www.readbyqxmd.com/read/23629479/cost-analysis-of-s1-and-xelox-as-adjuvant-therapy-for-gastric-cancer
#7
Jianping He, Feng Wen, Xude Yin, Pengfei Zhang, Zedong Du, Xiaofeng He, Yi Zhou, Ruilei Tang, Meng Li, Qiu Li
Both S1 and XELOX (capecitabine+oxaliplatin) have been recommended as an adjuvant treatment for gastric cancer according to the guidelines of the National Comprehensive Cancer Network (NCCN). This study compared the two regimens in terms of monetary costs, assuming equal efficacy of both regimens. Chemotherapy cost data of 188 patients were collected from the medical records, 91 for the S1 group and 97 for XELOX. Costs were classified as direct costs (chemotherapy, hospitalization, venous access, and tests), adverse event-related treatments costs, and societal (travel and time) costs...
August 2013: Anti-cancer Drugs
https://www.readbyqxmd.com/read/23143283/a-cost-effectiveness-study-of-eribulin-versus-standard-single-agent-cytotoxic-chemotherapy-for-women-with-previously-treated-metastatic-breast-cancer
#8
COMPARATIVE STUDY
Gilberto Lopes, Stefan Glück, Kiran Avancha, Alberto J Montero
Eribulin was FDA approved in 2012 as a treatment for patients with MBC who have previously received at least two prior chemotherapy regimens. The aim of this analysis was to assess the cost effectiveness of eribulin versus the three most commonly utilized drugs (TPC) in the EMBRACE trial: vinorelbine, gemcitabine, and capecitabine (X); and to other branded FDA approved drugs: ixabepilone (I), liposomal-doxorubicin (D), and nab-paclitaxel. We created a decision-analytical and a Markov model using clinical data from the EMBRACE trial...
January 2013: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/21839401/pharmacoeconomic-analysis-of-capecitabine-versus-5-fluorouracil-leucovorin-as-adjuvant-therapy-for-stage-iii-colon-cancer-in-taiwan
#9
COMPARATIVE STUDY
Tzu-Chi Hsu, Hong-Hwa Chen, Ming-Chin Yang, Hwei-Ming Wang, Jye-Hann Chuang, Shu-Wen Jao, Hsin-Chieh Chiang, Chung-Yu Wen, Jen-Hao Tseng, Li-Tzong Chen
OBJECTIVES: To assess the cost-effectiveness of oral capecitabine compared with intravenous bolus 5-fluorouracil/leucovorin (5-FU/LV) in the adjuvant treatment of stage III colon cancer in Taiwan from payer (Bureau of National Health Insurance [BNHI]) perspectives. METHODS: A health state-transition model was developed to estimate the incremental costs and effectiveness of capecitabine versus 5-FU/LV. The time horizons studied were: treatment duration (24 weeks) plus 36 months, 48 months, 60 months, 120 months, and lifetime...
July 2011: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/21701940/cost-effectiveness-of-lapatinib-plus-capecitabine-in-women-with-her2-metastatic-breast-cancer-who-have-received-prior-therapy-with-trastuzumab
#10
Thomas E Delea, Paul Tappenden, Oleg Sofrygin, Dominy Browning, Mayur M Amonkar, Jon Karnon, Mel D Walker, David Cameron
BACKGROUND: In a phase III trial of women with HER2+ metastatic breast cancer (MBC) previously treated with trastuzumab, an anthracycline, and taxanes (EGF100151), lapatinib plus capecitabine (L+C) improved time to progression (TTP) versus capecitabine monotherapy (C-only). In a trial including HER2+ MBC patients who had received at least one prior course of trastuzumab and no more than one prior course of palliative chemotherapy (GBG 26/BIG 03-05), continued trastuzumab plus capecitabine (T+C) also improved TTP...
October 2012: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/21609651/trastuzumab-for-the-treatment-of-her2-positive-metastatic-adenocarcinoma-of-the-stomach-or-gastro-oesophageal-junction
#11
REVIEW
G Norman, S Rice, E Spackman, L Stirk, A Danso-Appiah, D Suh, S Palmer, A Eastwood
This paper presents a summary of the evidence review group (ERG) report into trastuzumab for the treatment of human epidermal growth factor receptor 2 (HER2)-positive metastatic adenocarcinoma of the stomach (mGC) or gastro-oesophageal junction. HER2 positivity is defined by immunohistochemistry (IHC)3+ or IHC2+/fluorescence in situ hybridisation (FISH)+. The decision problem addressed was the testing of the whole mGC population with IHC and, for IHC2+ patients, also with FISH, followed by treatment of HER2-positive patients with trastuzumab combined with cisplatin and either capecitabine or 5-fluorouracil (5-FU) [HCX (trastuzumab, cisplatin, capecitabine)/fluorouracil (F)] compared with current standard NHS therapy...
May 2011: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/21358204/cost-minimisation-analysis-in-first-line-treatment-of-metastatic-colorectal-cancer-in-france-xelox-versus-folfox-6
#12
RANDOMIZED CONTROLLED TRIAL
G Perrocheau, J Bennouna, M Ducreux, M Hebbar, M Ychou, G Lledo, T Conroy, S Dominguez, R Faroux, V Florentin, J Y Douillard
OBJECTIVE: In a recent randomized study, we demonstrated that XELOX (oxaliplatin + oral capecitabine) was well tolerated and not inferior in terms of efficacy to the infusional FOLFOX-6 regimen in first-line treatment of metastatic colorectal cancer (mCRC). The objective of this additional analysis was to compare the cost of XELOX and FOLFOX-6. METHODS: This cost-minimisation study took into account costs related to drug acquisition, hospital care for chemotherapy administration and for serious adverse event management...
2010: Oncology
https://www.readbyqxmd.com/read/20350467/-economic-evaluation-of-capecitabine-use-as-first-line-treatment-in-patients-with-advanced-gastric-carcinoma-in-portugal
#13
Ana Macedo, Catarina Pereira, Joana Gonçalves, Conceição Sousa
INTRODUCTION: Gastric cancer is a highly prevalent disease in Portugal with impact on morbidity and mortality. The approach to a stomach cancer depends on the disease status and prognosis at the time of diagnosis. Surgical resection is the only potentially curative treatment. Up to now, palliative chemotherapy has been the only advantageous therapy option for patients with unresectable advanced gastric cancer or after recurrence, with a median survival of six to nine months. Among the drugs with a known antitumor activity, 5-fluorouracil (5-FU) and cisplatin have been widely used in advanced gastric cancer, either in monotherapy, or in combination...
November 2009: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/19663530/cost-effectiveness-analysis-of-capecitabine-compared-with-bolus-5-fluorouracil-l-leucovorin-for-the-adjuvant-treatment-of-colon-cancer-in-japan
#14
COMPARATIVE STUDY
Takeru Shiroiwa, Takashi Fukuda, Kojiro Shimozuma, Yasuo Ohashi, Kiichiro Tsutani
OBJECTIVE: A cost-effectiveness analysis of oral capecitabine versus intravenous bolus 5-fluorouracil/l-leucovorin (FU/LV) as adjuvant therapy in patients with stage 3 colon cancer was performed from a Japanese healthcare payer perspective. METHODS: Adjuvant therapy comprised 24 weeks of treatment with either oral capecitabine 1250 mg/m(2) twice daily on days 1-14 of a 21-day cycle or intravenous bolus FU 500 mg/m(2) and LV 250 mg/m(2) weekly for 6 weeks of an 8-week cycle (Roswell Park regimen)...
2009: PharmacoEconomics
https://www.readbyqxmd.com/read/19332722/cost-effectiveness-of-ixabepilone-plus-capecitabine-for-metastatic-breast-cancer-progressing-after-anthracycline-and-taxane-treatment
#15
RANDOMIZED CONTROLLED TRIAL
Shelby D Reed, Yanhong Li, Kevin J Anstrom, Kevin A Schulman
PURPOSE: Using data from a recent randomized trial, we evaluated the cost effectiveness of ixabepilone plus capecitabine versus capecitabine alone in patients with predominantly metastatic breast cancer considered to be taxane-resistant and previously treated with or resistant to an anthracycline. METHODS: We developed a stochastic decision-analytic model to represent data collected in the trial on medical resource use, health-related quality of life, and clinical outcomes...
May 1, 2009: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/19215190/xelox-versus-folfox6-as-an-adjuvant-treatment-in-colorectal-cancer-an-economic-analysis
#16
RANDOMIZED CONTROLLED TRIAL
Nikos Maniadakis, Vasilios Fragoulakis, Dimitrios Pectasides, George Fountzilas
OBJECTIVES: An economic analysis (based on interim data from a long-term, randomised, multi-centre, controlled, clinical trial) to evaluate chemotherapy with XELOX (capecitabine/oxaliplatin) versus FOLFOX6 (5Fluorouracil/leucovorin/oxaliplatin) as an adjuvant treatment for high risk colorectal cancer patients in Greece. METHODS: As survival rate was the same in the two arms, a cost-minimisation analysis was carried out, from the perspectives of the National Health Service (NHS), Social Insurance Funds (SIF) and patients in Greece...
March 2009: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/18783303/capecitabine-versus-bolus-fluorouracil-plus-leucovorin-folinic-acid-as-adjuvant-chemotherapy-for-patients-with-dukes-c-colon-cancer-economic-evaluation-in-an-italian-nhs-setting
#17
COMPARATIVE STUDY
Francesco Di Costanzo, Roberto Ravasio, Alberto Sobrero, Oscar Bertetto, Orazio Vinante, Gabriele Luppi, Roberto Labianca, Dino Amadori, Carlo Barone, Marco Carlo Merlano, Flavia Longo, Giovanni Mansueto, Lorenzo Antonuzzo, Silvia Gasperoni
BACKGROUND AND OBJECTIVE: In the recent X-ACT (Xeloda in Adjuvant Colon cancer Therapy) trial, oral capecitabine (Xeloda) demonstrated superior efficacy and an improved safety profile compared with infused fluorouracil + leucovorin (folinic acid) [FU+LV] in patients with Dukes' C colorectal cancer. We used the X-ACT results to determine the cost effectiveness of capecitabine compared with FU+LV from the perspective of the Italian National Health Service (NHS). METHODS: Medical resource use data were collected throughout the treatment period...
2008: Clinical Drug Investigation
https://www.readbyqxmd.com/read/18042483/cost-effectiveness-analysis-of-bevacizumab-combined-with-chemotherapy-for-the-treatment-of-metastatic-colorectal-cancer-in-japan
#18
COMPARATIVE STUDY
Takeru Shiroiwa, Takashi Fukuda, Kiichiro Tsutani
BACKGROUND: Rapid progress has been made in the treatment of metastatic colorectal cancer (mCRC). New treatment regimens for mCRC include not only cytotoxic chemotherapy but also targeted monoclonal antibodies, including bevacizumab. However, bevacizumab is an expensive medication, which costs from 300,000 yen to 400,000 yen (US $2500-$3300) per month. OBJECTIVE: The purpose of this cost-effectiveness analysis was to examine the economic efficiency of treating mCRC with bevacizumab plus chemotherapy versus chemotherapy alone in Japan...
October 2007: Clinical Therapeutics
https://www.readbyqxmd.com/read/17241512/xeloda-in-adjuvant-colon-cancer-therapy-x-act-trial-overview-of-efficacy-safety-and-cost-effectiveness
#19
REVIEW
Chris J Twelves
The X-ACT (Xeloda in Adjuvant Colon Cancer Therapy) trial compared the efficacy and safety of the oral fluoropyrimidine capecitabine with bolus 5-fluorouracil (5-FU)/leucovorin (LV; Mayo Clinic regimen) as adjuvant therapy for stage III colon cancer. A total of 1987 patients were enrolled at 164 centers worldwide. Disease-free survival (primary study endpoint) in the capecitabine arm was at least equivalent to that in the 5-FU/LV arm; the upper limit of the hazard ratio was significantly (P < 0.001) below the predefined margins for noninferiority...
November 2006: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/16981802/pharmacy-benefit-spending-on-oral-chemotherapy-drugs
#20
Frederic R Curtiss
BACKGROUND: Pharmacy benefits have historically excluded injectable drugs, resulting in coverage of injectable drugs under the medical benefit. High-cost biologics and other new drug therapies are often injectables and therefore have not presented cost threats to pharmacy benefits. The U.S. Food and Drug Administration approval of capecitabine, an oral form of fluorouracil, in 1998, and imatinib mesylate in oral dose form for chronic myeloid leukemia, in 2001, signaled a new period in budget forecasting for pharmacy benefits, particularly for small, self-insured employers for whom a drug with a cost of 25,000 dollars per year of therapy for 1 patient could increase total pharmacy benefit costs by 10% or more...
September 2006: Journal of Managed Care Pharmacy: JMCP
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