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Congenital Heart AND Infant* AND Mortal*

Yıldız Perk, Mine Özdil
Respiratory syncytial virus is one of the major causes of respiratory tract infections during infancy with high rates of hospitalization and mortality during the first years of life. It is the most common cause of acute bronchiolitis and viral pneumonia in children below two years of age and second the most common cause of postneonatal infant mortality all around the world following malaria. In addition, the virus has been causally linked to recurrent wheezing and associated with pediatric asthma. The respiratory syncytial virus infections tend to be severe in high risk patients such as patients below six months of age, with prematurity, congenital heart diseases, neuromuscular diseases and immune deficiencies...
June 2018: Türk Pediatri Arşivi
Elisa Siano, Giuseppe Lauriti, Silvia Ceccanti, Augusto Zani
AIM:  The main purpose of this study was to investigate if necrotizing enterocolitis (NEC) has a different presentation and outcome in patients with congenital heart defect (CHD) (cardiogenic NEC) from those without (classical NEC). MATERIALS AND METHODS:  A systematic review of the literature on the characteristics of infants with NEC and CHD was performed by three independent investigators using a defined strategy (PubMed, Cochrane, Embase, and Web of Science)...
August 15, 2018: European Journal of Pediatric Surgery
Nelson D Pace, Matthew E Oster, Nina E Forestieri, Dianne Enright, Jessica Knight, Robert E Meyer
OBJECTIVES: To examine the first-year survival of infants with congenital heart defects (CHDs) and investigate the potential role of socioeconomic and demographic factors on survival. METHODS: Subjects included 15 533 infants with CHDs born between 2004 and 2013 ascertained by the NC Birth Defects Monitoring Program. We classified CHDs into the following 3 groups: critical univentricular ( n = 575), critical biventricular ( n = 1494), and noncritical biventricular ( n = 13 345)...
August 15, 2018: Pediatrics
Silvia Baldacci, Francesca Gorini, Michele Santoro, Anna Pierini, Fabrizio Minichilli, Fabrizio Bianchi
INTRODUCTION: Congenital anomalies (CAs) represent one of the main cause of foetal death, infant mortality and morbidity, and long-term disability. CAs have been object of systematic registration activity for a long-time in many geographical areas in Europe and worldwide. CAs are often associated with disabilities of different types and severity, including the developed Countries worldwide. According to the World Health Organization (WHO), each year approximately 3,2 million of children worldwide are born with a CA and approximately 300,000 newborns with a diagnosis of birth defect die within the first 28 days of life...
May 2018: Epidemiologia e Prevenzione
Marc-André Buchwald, Ursula Laasner, Christian Balmer, Vincenzo Cannizzaro, Beatrice Latal, Vera Bernet
INTRODUCTION: Children with trisomy 21 are prone to postoperative chylothorax, caused by malformation of the lymphatic system, after cardiac surgery. The clinical course of patients diagnosed with postoperative chylothorax and trisomy 21 was compared to that of patients without dysmorphic syndromes. Additionally, differences between the groups in composition, amount, and duration of chyle were analyzed to better understand chylothorax in patients with trisomy 21. MATERIALS AND METHODS: Retrospective cohort study using inpatient clinical databases during a 10-year period...
July 6, 2018: Journal of Pediatric Surgery
Hui Luo, Gang Qin, Lu Wang, Zhi Ye, Yundan Pan, Lingjin Huang, Wanjun Luo, Qulian Guo, Yonggang Peng, E Wang
OBJECTIVES: There is still controversy about whether an infant should have cardiac surgery concomitant with ongoing persistent pneumonia. This study analyzes the outcome of surgical treatment for infants with left-to-right shunt congenital heart disease accompanied with persistent pneumonia and discusses the perioperative management strategies for these cases. DESIGN: This is a retrospective cohort study. SETTING: This study was conducted in an academic hospital and is a single-center study...
May 27, 2018: Journal of Cardiothoracic and Vascular Anesthesia
Lindsay M Ryerson, Scott Pharis, Charissa Pockett, Reeni Soni, Deborah Fruitman, Kristine J Guleserian, Melissa Nater, Stephen C Raynor, Andrew S Mackie, Bryan Dicken
BACKGROUND: Infants with heterotaxy syndrome (HS) have abnormal lateralization of organs along the right-left body axis. Intestinal rotation abnormalities (IRAs) are a potential source of morbidity and mortality. For this study, our objective was to prospectively observe a cohort of infants with HS and determine the incidence and natural history of IRA. METHODS: Infants ≤6 months of age with HS were enrolled in this prospective observational study. Exclusion criteria were other congenital abnormalities that necessitated abdominal surgery...
August 2018: Pediatrics
Janet M Simsic, Christina Phelps, Kristin Kirchner, Kirby-Rose Carpenito, Robin Allen, Holly Miller-Tate, Karen Texter, Mark Galantowicz
OBJECTIVE: Interstage readmissions are common in infants with single ventricle congenital heart disease undergoing staged surgical palliation. We retrospectively examined readmissions during the interstage period. DESIGN: Retrospective analysis. SETTING: The Heart Center at Nationwide Children's Hospital, Columbus, Ohio. PATIENTS: Newborns undergoing hybrid stage 1 palliation from January 2012 to December 2016 who survived to hospital discharge and were followed at our institution...
July 18, 2018: Congenital Heart Disease
Raheel Rizwan, Farhan Zafar, Clifford Chin, James Tweddell, Roosevelt Bryant, David Morales
BACKGROUND: Infants awaiting heart transplantation (HTx) have the highest waitlist mortality compared to other HTx patients. This study analyzed the impact of weight and other factors on waitlist and post-HTx outcomes in infants. METHODS: All infants on HTx waitlist in the United Network for Organ Sharing database from October 1987-June 2016 were divided into weight groups: <2.5Kg, 2.5-3.9Kg and >4Kg. Survival from listing regardless of transplant was compared using Kaplan-Meier analysis...
July 12, 2018: Annals of Thoracic Surgery
Mayumi Tsuji, Eiji Shibata, Seiichi Morokuma, Rie Tanaka, Ayako Senju, Shunsuke Araki, Masafumi Sanefuji, Chihaya Koriyama, Megumi Yamamoto, Yasuhiro Ishihara, Koichi Kusuhara, Toshihiro Kawamoto
BACKGROUND: Heavy metals are widely distributed in the environment. Recent reports have demonstrated the risk of preterm birth following heavy metal exposure. Preterm births are classified as early and late, depending on the duration of pregnancy, and are associated with increased risk of congenital illnesses such as heart failure, asthma, etc. Particularly, early preterm births carry a higher risk of mortality; however, the differential effects of heavy metal exposure on early and late preterm births are unknown...
June 28, 2018: Environmental Research
Anton A Kovalenko, Erik Eik Anda, Jon Øyvind Odland, Evert Nieboer, Tormod Brenn, Alexandra Krettek
Cardiovascular malformations are one of the most common birth defects among newborns and constitute a leading cause of perinatal and infant mortality. Although some risk factors are recognized, the causes of cardiovascular malformations (CVMs) remain largely unknown. In this study, we aim to identify risk factors for ventricular septal defects (VSDs) in Northwest Russia. The study population included singleton births registered in the Murmansk County Birth Registry (MCBR) between 1 January 2006 and 31 December 2011...
June 24, 2018: International Journal of Environmental Research and Public Health
Dai Kimura, Jordy Saravia, Sridhar Jaligama, Isabella McNamara, Luan D Vu, Ryan D Sullivan, Salvatore Mancarella, Dahui You, Stephania A Cormier
Pulmonary hypertension (PH) has been observed in up to 75% of infants with moderate to severe respiratory syncytial virus (RSV) bronchiolitis and is associated with significant morbidity and mortality in infants with congenital heart disease. The purpose of this study was to establish a mouse model of PH secondary to RSV bronchiolitis that mimics the disease etiology as it occurs in infants. Neonatal mice were infected with RSV at 5 days of age, and then re-infected 4 weeks later. Serum free medium was administered to age-matched mice as control...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Abigail R Strang, Jenna W Briddell, Patrick C Barth, Udayan K Shah, Aaron Chidekel
INTRODUCTION: An increasing number of tracheostomies are performed in infants with complex comorbidities including bronchopulmonary dysplasia (BPD) and congenital heart disease (CHD). With this shift in indications, there is an urgent need to characterize outcomes in this population. METHODS: This 5-year retrospective chart review assessed rates of 12-month mortality in infants who were ≤12 months of age at the time of tracheostomy at a tertiary care pediatric hospital and risk factors associated with death...
June 3, 2018: Pediatric Pulmonology
Daniel Hurtado-Sierra, Juan Calderón-Colmenero, Pedro Curi-Curi, Jorge Cervantes-Salazar, Juan Pablo Sandoval, José Antonio García-Montes, Antonio Benita-Bordes, Samuel Ramírez-Marroquin
Background: Delayed sternal closure (DSC) after cardiac surgery is a therapeutic option in the treatment of the severely impaired heart in pediatric cardiac surgery. Methods: A single-center retrospective review of all bypass surgeries performed over a 10-year period (2003-2012). Results: Of a total of 2325 patients registered in our database, the DSC group included 259 cases (11%), and the remaining 2066 cases (89%) constituted the control group (PSC)...
2018: BioMed Research International
Amy M O'Connor, Andrew H Smith, Kim Crum, Todd L Edwards, Prince J Kannankeril
BACKGROUND: Atrial tachycardia (AT) after infant congenital heart disease (CHD) surgery is associated with increased mortality. Polymorphisms in PITX2 (rs2200733) and IL6 (rs1800795) are associated with postoperative atrial fibrillation in adults but have not been studied in CHD. The objective was to test the hypothesis that clinical factors and variants in PITX2 and IL6 are associated with postoperative AT in infants with CHD. METHODS: Infants (<1 year of age) undergoing CHD surgery between September 2007 and May 2016 were included...
August 2018: American Heart Journal
Kimberly A Holst, Joseph A Dearani, Sameh M Said, Ryan R Davies, Christian Pizarro, Christopher Knott-Craig, T K Susheel Kumar, Vaughn Starnes, S Ram Kumar, Sara K Pasquali, Dylan P Thibault, James M Meza, Kevin D Hill, Karen Chiswell, Jeffrey P Jacobs, Marshall L Jacobs
BACKGROUND: Ebstein anomaly (EA) encompasses a broad spectrum of morphology and clinical presentation. Those who are symptomatic early in infancy are generally at highest risk, but there are limited data regarding multi-centric practice patterns and outcomes. We analyzed multi-institutional data concerning operations and outcomes in neonates and infants with EA. METHODS: Index operations reported in the STS Congenital Heart Surgery Database (2010-2016) were potentially eligible for inclusion...
May 16, 2018: Annals of Thoracic Surgery
Sotiria C Apostolopoulou, George A Vagenakis, Alexandros Tsoutsinos, Felicia Kakava, Spyridon Rammos
End-stage heart failure (HF) frequently needs continuous inotropic support in hospital and has high morbidity and mortality in absence of heart transplantation. This study reports outcome, efficacy, and safety of continuous ambulatory inotropes (AI) and/or periodic levosimendan (LS) infusions in pediatric HF patients. The study included 27 patients, median age 9.4 (0.1-26.1) years, with severe HF (6 myocarditis, 13 dilated cardiomyopathy, 2 restrictive cardiomyopathy, 6 repaired congenital heart disease). Dobutamine and milrinone AI were administered in 21 patients through a permanent central catheter for median duration 1...
May 18, 2018: Pediatric Cardiology
Mohd Nizam Mat Bah, Mohd Hanafi Sapian, Mohammad Tamim Jamil, Amelia Alias, Norazah Zahari
Critical congenital heart disease (CCHD) is associated with significant morbidity and mortality. However, data on survival of CCHD and the risk factors associated with its mortality are limited. This study examined CCHD survival and the risk factors for CCHD mortality. Using a retrospective cohort study of infants born with CCHD from 2006 to 2015, survival over 10 years was estimated using Kaplan-Meier analysis, and the risk factors for mortality were analyzed using multivariate Cox proportional hazards regression...
May 14, 2018: Pediatric Cardiology
Jo Wray, Katherine Brown, Jenifer Tregay, Sonya Crowe, Rachel Knowles, Kate Bull, Faith Gibson
BACKGROUND: Congenital heart disease (CHD) is the most common class of birth defects, which encompasses a broad spectrum of severity ranging from relatively minor to extremely complex. Improvements in surgery and intensive care have resulted in an increasing number of infants with the most complex lesions surviving after surgery until the time of discharge from the hospital, but there remain concerns about out-of-hospital mortality, variability in how services are provided at the time of discharge and beyond, and difficulties experienced by some families in accessing care...
May 9, 2018: Journal of Medical Internet Research
Jennifer G Jetton, Louis J Boohaker, Sidharth K Sethi, Sanjay Wazir, Smriti Rohatgi, Danielle E Soranno, Aftab S Chishti, Robert Woroniecki, Cherry Mammen, Jonathan R Swanson, Shanty Sridhar, Craig S Wong, Juan C Kupferman, Russell L Griffin, David J Askenazi
Background: Single-center studies suggest that neonatal acute kidney injury (AKI) is associated with poor outcomes. However, inferences regarding the association between AKI, mortality, and hospital length of stay are limited due to the small sample size of those studies. In order to determine whether neonatal AKI is independently associated with increased mortality and longer hospital stay, we analyzed the Assessment of Worldwide Acute Kidney Epidemiology in Neonates (AWAKEN) database...
November 2017: The lancet child & adolescent health
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