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https://www.readbyqxmd.com/read/30315118/bright-spots-physical-activity-investments-that-work-gators-in-motion-a-holistic-approach-to-sport-based-youth-development
#1
Trevor Bopp, E Paul Roetert
No abstract text is available yet for this article.
October 12, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/30073236/evolutionary-niching-in-the-gator-genetic-algorithm-for-molecular-crystal-structure-prediction
#2
Farren Curtis, Timothy Rose, Noa Marom
The goal of molecular crystal structure prediction (CSP) is to find all the plausible polymorphs for a given molecule. This requires performing global optimization over a high-dimensional search space. Genetic algorithms (GAs) perform global optimization by starting from an initial population of structures and generating new candidate structures by breeding the fittest structures in the population. Typically, the fitness function is based on relative lattice energies, such that structures with lower energies have a higher probability of being selected for mating...
August 3, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/29769712/author-correction-szt2-dictates-gator-control-of-mtorc1-signalling
#3
Min Peng, Na Yin, Ming O Li
In the originally published version of this Letter, there was an error in Extended Data Fig. 7e and the corresponding uncropped blots in the Supplementary Information. The actin bands in the last blot of Extended Data Fig. 7e were duplicates  of the corresponding actin bands in the last blot of Extended Data Fig. 7 f. (In the uncropped blot for Extended Data Fig. 7e, the actin bands were mislabelled as 'WDR59' and this led to the error.) Extended Data Fig. 7 and the Supplementary Information of the original Letter have been corrected online...
June 2018: Nature
https://www.readbyqxmd.com/read/29625022/l-gator-genetic-association-testing-for-a-longitudinally-measured-quantitative-trait-in-samples-with-related-individuals
#4
Xiaowei Wu, Mary Sara McPeek
In complex-trait mapping, when each subject has multiple measurements of a quantitative trait over time, power for detecting genetic association can be gained by the inclusion of all measurements and not just single time points or averages in the analysis. To increase power and control type 1 error, one should account for dependence among observations for a single individual as well as dependence between observations of related individuals if they are present in the sample. We propose L-GATOR, a retrospective, mixed-effects method for association mapping of longitudinally measured traits in samples with related individuals...
April 5, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29481864/depdc5-and-nprl3-modulate-cell-size-filopodial-outgrowth-and-localization-of-mtor-in-neural-progenitor-cells-and-neurons
#5
Philip H Iffland, Marianna Baybis, Allan E Barnes, Richard J Leventer, Paul J Lockhart, Peter B Crino
Mutations in DEPDC5 and NPRL3 subunits of GATOR1, a modulator of mechanistic target of rapamycin (mTOR), are linked to malformations of cortical development (MCD). Brain specimens from these individuals reveal abnormal cortical lamination, altered cell morphology, and hyperphosphorylation of ribosomal S6 protein (PS6), a marker for mTOR activation. While numerous studies have examined GATOR1 subunit function in non-neuronal cell lines, few have directly assessed loss of GATOR1 subunit function in neuronal cell types...
June 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29481740/gator-a-first-principles-genetic-algorithm-for-molecular-crystal-structure-prediction
#6
Farren Curtis, Xiayue Li, Timothy Rose, Álvaro Vázquez-Mayagoitia, Saswata Bhattacharya, Luca M Ghiringhelli, Noa Marom
We present the implementation of GAtor, a massively parallel, first-principles genetic algorithm (GA) for molecular crystal structure prediction. GAtor is written in Python and currently interfaces with the FHI-aims code to perform local optimizations and energy evaluations using dispersion-inclusive density functional theory (DFT). GAtor offers a variety of fitness evaluation, selection, crossover, and mutation schemes. Breeding operators designed specifically for molecular crystals provide a balance between exploration and exploitation...
April 10, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29127423/tumor-suppressor-nprl2-induces-ros-production-and-dna-damage-response
#7
Yinxing Ma, Licia Silveri, John LaCava, Svetlana Dokudovskaya
The SEA/GATOR complex is an essential regulator of the mTORC1 pathway. In mammals the GATOR1 complex is composed of the proteins DEPDC5, NPRL2 and NPRL3. GATOR1 serves as an mTORC1 inhibitor and activates the mTORC1-modulating RagA GTPase. However, several GATOR members have mTORC1 independent functions. Here we characterize mammalian cells overexpressing the GATOR1 component NPRL2. We demonstrate that, in the cells with active p53, ectopic expression of NPRL2 induces NOX2-dependent production of reactive oxygen species and DNA damage...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28613413/commentary-gator-complex-associated-epilepsies
#8
Johannes R Lemke
No abstract text is available yet for this article.
July 2017: Epilepsia
https://www.readbyqxmd.com/read/28199315/szt2-dictates-gator-control-of-mtorc1-signalling
#9
Min Peng, Na Yin, Ming O Li
Mechanistic target of rapamycin complex 1 (TORC1) integrates nutrient signals to control cell growth and organismal homeostasis across eukaryotes. The evolutionarily conserved GATOR complex regulates mTORC1 signalling through Rag GTPases, and GATOR1 displays GTPase activating protein (GAP) activity for RAGA and RAGB (RAGA/B) and GATOR2 has been proposed to be an inhibitor of GATOR1. Furthermore, the metazoan-specific SESN proteins function as guanine nucleotide dissociation inhibitors (GDIs) for RAGA/B, and interact with GATOR2 with unknown effects...
March 16, 2017: Nature
https://www.readbyqxmd.com/read/27891451/assessing-the-reliability-of-digitalized-cephalometric-analysis-in-comparison-with-manual-cephalometric-analysis
#10
Mohammed Umar Farooq, Mohd Asadullah Khan, Shahid Imran, Ayesha Sameera, Arshad Qureshi, Syed Afroz Ahmed, Sujan Kumar, Mohd Aziz Ur Rahman
INTRODUCTION: For more than seven decades orthodontist used cephalometric analysis as one of the main diagnostic tools which can be performed manually or by software. The use of computers in treatment planning is expected to avoid errors and make it less time consuming with effective evaluation and high reproducibility. AIM: This study was done to evaluate and compare the accuracy and reliability of cephalometric measurements between computerized method of direct digital radiographs and conventional tracing...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27308486/sestrins-regulate-mtorc1-via-rrags-the-riddle-of-gator
#11
Andrei V Budanov
SESTRINs, proteins encoded by the SESN1-3 genes in mammals, are well-established suppressors of the mechanistic target of rapamycin complex 1 (mTORC1) kinase. Recently, we found that SESTRINs bind the GATOR2 protein complex, which is a regulator of RRAGA/B guanosine triphosphatase. Three independent studies support the RRAGA/B-dependence of mTORC1 regulation by SESTRINs; however, the role of GATOR2 in this process requires clarification.
July 2015: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/27227887/the-loss-of-lam2-and-npr2-npr3-diminishes-the-vacuolar-localization-of-gtr1-gtr2-and-disinhibits-torc1-activity-in-fission-yeast
#12
Ning Ma, Yan Ma, Akio Nakashima, Ushio Kikkawa, Tomoyuki Furuyashiki
In mammalian cells, mTORC1 activity is regulated by Rag GTPases. It is thought that the Ragulator complex and the GATOR (GAP activity towards Rags) complex regulate RagA/B as its GDP/GTP exchange factor (GEF) and GTPase-activating protein (GAP), respectively. However, the functions of components in these complexes remain elusive. Using fission yeast as a model organism, here we found that the loss of Lam2 (SPBC1778.05c), a homolog of a Ragulator component LAMTOR2, as well as the loss of Gtr1 or Gtr2 phenocopies the loss of Npr2 or Npr3, homologs of GATOR components Nprl2 or Nprl3, respectively...
2016: PloS One
https://www.readbyqxmd.com/read/27173016/involvement-of-gator-complex-genes-in-familial-focal-epilepsies-and-focal-cortical-dysplasia
#13
Sarah Weckhuysen, Elise Marsan, Virginie Lambrecq, Cécile Marchal, Mélanie Morin-Brureau, Isabelle An-Gourfinkel, Michel Baulac, Martine Fohlen, Christine Kallay Zetchi, Margitta Seeck, Pierre de la Grange, Bart Dermaut, Alfred Meurs, Pierre Thomas, Francine Chassoux, Eric Leguern, Fabienne Picard, Stéphanie Baulac
OBJECTIVE: The discovery of mutations in DEPDC5 in familial focal epilepsies has introduced a novel pathomechanism to a field so far dominated by ion channelopathies. DEPDC5 is part of a complex named GAP activity toward RAGs (GATOR) complex 1 (GATOR1), together with the proteins NPRL2 and NPRL3, and acts to inhibit the mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) pathway. GATOR1 is in turn inhibited by the GATOR2 complex. The mTORC1 pathway is a major signaling cascade regulating cell growth, proliferation, and migration...
June 2016: Epilepsia
https://www.readbyqxmd.com/read/27166823/the-gator2-component-wdr24-regulates-torc1-activity-and-lysosome-function
#14
Weili Cai, Youheng Wei, Michal Jarnik, John Reich, Mary A Lilly
TORC1 is a master regulator of metabolism in eukaryotes that responds to multiple upstream signaling pathways. The GATOR complex is a newly defined upstream regulator of TORC1 that contains two sub-complexes, GATOR1, which inhibits TORC1 activity in response to amino acid starvation and GATOR2, which opposes the activity of GATOR1. While the GATOR1 complex has been implicated in a wide array of human pathologies including cancer and hereditary forms of epilepsy, the in vivo relevance of the GATOR2 complex remains poorly understood in metazoans...
May 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27116923/traumatic-amputation-of-finger-from-an-alligator-snapping-turtle-bite
#15
Robert D Johnson, Cynthia L Nielsen
Legend states that the alligator snapping turtle (Macrochelys temminckii) should be handled with extreme caution as it has jaw strength powerful enough to bite a wooden broomstick in half. Tales of bite injuries from what is the largest freshwater turtle in North America exist anecdotally, yet there are few descriptions of medical encounters for such. The risk of infection from reptilian bites to the hand in an aquatic environment warrants thorough antibiotic treatment in conjunction with hand surgery consultation...
June 2016: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/27090747/driving-along-the-zinc-road
#16
Robert J Cousins
After having written hundreds of research articles, reviews, and book chapters, I find it awkward to pen an autobiography. I still do use a pen. As stated by others in the nutrition field who have written of their own experiences in a perspective article for the Annual Review of Nutrition, my course through this field of science has been serendipitous. My interest in nutrition developed during my experiences with horses and then Angus cattle and entry into an animal science degree program. As the age of molecular biology was unfolding, I pursued a PhD in nutritional biochemistry with Hamilton Eaton at the University of Connecticut followed by postdoctoral work with Hector DeLuca at the University of Wisconsin, working on vitamins A and D, respectively...
July 17, 2016: Annual Review of Nutrition
https://www.readbyqxmd.com/read/26781224/rag-gtpase-in-amino-acid-signaling
#17
REVIEW
Joungmok Kim, Eunjung Kim
Rag small GTPases were identified as the sixth subfamily of Ras-related GTPases. Compelling evidence suggests that Rag heterodimer (RagA/B and RagC/D) plays an important role in amino acid signaling toward mechanistic target of rapamycin complex 1 (mTORC1), which is a central player in the control of cell growth in response to a variety of environmental cues, including growth factors, cellular energy/oxygen status, and amino acids. Upon amino acid stimulation, active Rag heterodimer (RagA/B(GTP)-RagC/D(GDP)) recruits mTORC1 to the lysosomal membrane where Rheb resides...
April 2016: Amino Acids
https://www.readbyqxmd.com/read/26390293/corrigendum-sestrin2-inhibits-mtorc1-through-modulation-of-gator-complexes
#18
Jeong Sig Kim, Seung-Hyun Ro, Myungjin Kim, Hwan-Woo Park, Ian A Semple, Haeli Park, Uhn-Soo Cho, Wei Wang, Kun-Liang Guan, Michael Karin, Jun Hee Lee
No abstract text is available yet for this article.
2015: Scientific Reports
https://www.readbyqxmd.com/read/25934700/sea-you-later-alli-gator-a-dynamic-regulator-of-the-torc1-stress-response-pathway
#19
REVIEW
Svetlana Dokudovskaya, Michael P Rout
Cells constantly adapt to various environmental changes and stresses. The way in which nutrient and stress levels in a cell feed back to control metabolism and growth are, unsurprisingly, extremely complex, as responding with great sensitivity and speed to the 'feast or famine, slack or stress' status of its environment is a central goal for any organism. The highly conserved target of rapamycin complex 1 (TORC1) controls eukaryotic cell growth and response to a variety of signals, including nutrients, hormones and stresses, and plays the key role in the regulation of autophagy...
June 15, 2015: Journal of Cell Science
https://www.readbyqxmd.com/read/25819761/sestrin2-inhibits-mtorc1-through-modulation-of-gator-complexes
#20
Jeong Sig Kim, Seung-Hyun Ro, Myungjin Kim, Hwan-Woo Park, Ian A Semple, Haeli Park, Uhn-Soo Cho, Wei Wang, Kun-Liang Guan, Michael Karin, Jun Hee Lee
Sestrins are stress-inducible metabolic regulators that suppress a wide range of age- and obesity-associated pathologies, many of which are due to mTORC1 overactivation. Upon various stresses, the Sestrins inhibit mTORC1 activity through an indirect mechanism that is still unclear. GATORs are recently identified protein complexes that regulate the activity of RagB, a small GTPase essential for mTORC1 activation. GATOR1 is a GTPase activating protein (GAP) for RagB whereas GATOR2 functions as an inhibitor of GATOR1...
2015: Scientific Reports
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