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diastolic heart failure; atrial fibrillation; valvular heart diseases

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https://www.readbyqxmd.com/read/30467193/fifty-seven-year-old-man-with-progressive-dyspnoea
#1
Nikoloz Koshkelashvili, Priya Kohli, Jason Linefsky
CLINICAL INTRODUCTION: A 57-year-old man from the USA with a history of atrial fibrillation and hypertension was evaluated for progressive dyspnoea and decreased energy. The patient denied a history of congestive heart failure, systemic symptoms or myocardial infarction. He was found to have a 3/6 holosystolic murmur radiating to the axilla. Transthoracic echocardiography (TTE) reported a reduced ejection fraction of 40%, mitral valve regurgitation and absence of interatrial shunts. The remaining cardiac valves were without abnormality...
November 22, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/30129379/prevalence-and-distribution-of-left-ventricular-diastolic-dysfunction-in-treated-patients-with-long-lasting-hypertension
#2
Ewa Świerblewska, Jacek Wolf, Katarzyna Kunicka, Beata Graff, Katarzyna Polonis, Michał Hoffmann, Marzena Chrostowska, Anna Szyndler, Piotr Bandosz, Beata Graff, Krzysztof Narkiewicz
BACKGROUND: Although the presence of sub-clinical left ventricular diastolic dysfunction (LVDD) increases cardiovascular risk, the current ESH/ESC guidelines do not include the presence of this condition in the list of target organ damage or cardiovascular risk charts dedicated to the hypertensive population. Several conditions may predict the LVDD occurrence, however, clustering of these factors with hypertension makes the relationship less clear. Therefore, the aim of this study was to evaluate both the occurrence and the severity of diastolic dysfunction in a large cohort of treated hypertensives...
December 2018: Blood Pressure
https://www.readbyqxmd.com/read/30067272/prevalence-clinical-characteristics-and-outcomes-of-valvular-atrial-fibrillation-in-a-cohort-of-african-patients-with-acute-heart-failure-insights-from-the-thesus-hf-registry
#3
Mahmoud U Sani, Beth A Davison, Gad Cotter, Bongani M Mayosi, Christopher Edwards, Okechukwu S Ogah, Albertino Damasceno, Dike B Ojji, Anastase Dzudie, Charles Mondo, Charles Kouam Kouam, Ahmed Suliman, Gerald Yonga, Serigne Abdou Ba, Fikru Maru, Bekele Alemayehu, Karen Sliwa
INTRODUCTION: Rheumatic heart disease (RHD) is the commonest cause of valvular heart disease and a common cause of heart failure in sub-Saharan Africa (SSA). Atrial fibrillation (AF) complicates RHD, precipitates and worsens heart failure and cause unfavourable outcomes. We set out to describe the prevalence, clinical characteristics and outcomes of valvular atrial fibrillation in a cohort of African patients with acute heart failure (AHF). METHODS: The sub-Saharan Africa Survey of Heart Failure (THESUS-HF) was a prospective, observational survey of AHF in nine countries...
May 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/30057766/risk-factors-for-incident-heart-failure-with-preserved-or-reduced-ejection-fraction-and-valvular-heart-failure-in-a-community-based-cohort
#4
Fei Fei Gong, Michael V Jelinek, Julian M Castro, Jennifer M Coller, Michele McGrady, Umberto Boffa, Louise Shiel, Danny Liew, Rory Wolfe, Simon Stewart, Alice J Owen, Henry Krum, Christopher M Reid, David L Prior, Duncan J Campbell
Background: The lack of effective therapies for heart failure with preserved ejection fraction (HFpEF) reflects an incomplete understanding of its pathogenesis. Design: We analysed baseline risk factors for incident HFpEF, heart failure with reduced ejection fraction (HFrEF) and valvular heart failure (VHF) in a community-based cohort. Methods: We recruited 2101 men and 1746 women ≥60 years of age with hypertension, diabetes, ischaemic heart disease (IHD), abnormal heart rhythm, cerebrovascular disease or renal impairment...
2018: Open Heart
https://www.readbyqxmd.com/read/30051405/sex-differences-in-heart-failure
#5
Gianluigi Savarese, Domenico D'Amario
Heart failure (HF) represents a global pandemic health problem with a high impact on health-care costs, affecting about 26 million adults worldwide. The overall HF prevalence and incidence are ~2% and ~0.2% per year, respectively, in Western countries, with half of the HF population with reduced ejection fraction (HFpEF) and half with preserved (HFpEF) or mid-range ejection fraction (HFmrEF). Sex differences may exist in HF. More males have HFrEF or HFmrEF and an ischemic etiology, whereas more females have HFpEF and hypertension, diastolic dysfunction, and valvular pathologies as HF etiologies...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29805414/intraventricular-dyssynchrony-among-patients-with-left-bundle-branch-block
#6
Abdul Sami, Malik Faisal Iftekhar, Imran Khan, Rafiullah Jan
Objective: To determine the frequency of intraventricular dyssynchrony among patients with left bundle branch block. Methods: The study was conducted at Hayatabad Medical Complex, Peshawar, from January, 2017 to July, 2017. All patients aged 18 years and above with Left Bundle Branch Block (LBBB) on ECG with or without heart failure were included in the study. Patients with valvular heart disease, predominant diastolic heart failure, acute coronary syndromes or coronary revascularization in last three months and atrial fibrillation were excluded...
March 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29713021/risk-of-cardiomyopathy-and-cardiac-arrhythmias-in-patients-with-nonalcoholic-fatty-liver-disease
#7
REVIEW
Quentin M Anstee, Alessandro Mantovani, Herbert Tilg, Giovanni Targher
Nonalcoholic fatty liver disease (NAFLD) is a common, progressive liver disease that affects up to one-quarter of the adult population worldwide. The clinical and economic burden of NAFLD is mainly due to liver-related morbidity and mortality (nonalcoholic steatohepatitis, cirrhosis or hepatocellular carcinoma) and an increased risk of developing fatal and nonfatal cardiovascular disease, chronic kidney disease and certain types of extrahepatic cancers (for example, colorectal cancer and breast cancer). Additionally, there is now accumulating evidence that NAFLD adversely affects not only the coronary arteries (promoting accelerated coronary atherosclerosis) but also all other anatomical structures of the heart, conferring an increased risk of cardiomyopathy (mainly left ventricular diastolic dysfunction and hypertrophy, leading to the development of congestive heart failure), cardiac valvular calcification (mainly aortic-valve sclerosis), cardiac arrhythmias (mainly atrial fibrillation) and some cardiac conduction defects...
July 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28451450/serum-albumin-level-and-hospital-mortality-in-acute-non-ischemic-heart-failure
#8
Arnaud Ancion, Sophie Allepaerts, Cécile Oury, Anne-Stephan Gori, Luc A Piérard, Patrizio Lancellotti
AIMS: Hypoalbuminemia is common in heart failure (HF), especially in elderly patients. It is associated with an increased risk of death. The present study sought to examine the prognostic significance of serum albumin level in the prediction of hospital mortality in patients admitted for acute non-ischemic HF. METHODS AND RESULTS: We examined the association between albumin and hospital mortality in a cohort of 546 patients admitted for acute non-ischemic HF. None of the patients had infectious disease, severe arrhythmias (atrial fibrillation, ventricular tachycardia, ventricular fibrillation), required invasive ventilation, or presented with acute coronary syndrome or primary valvular disease...
May 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/27180566/-the-use-of-echocardiography-left-ventricular-filling-pressures-in-hypertensive-patients-with-heart-failure-and-preserved-systolic-function-in-a-north-africa-unit-day
#9
N Ali-Tatar Chentir, Y Tir, L Ouabdesselam, M-T Chentir
OBJECTIVE: To assess the left ventricular (LV) filling pressures by Doppler Tissulaire Imaging (DTI) in the management of hypertensive patients with heart failure and preserved systolic function (HF-PEF) in our outpatient clinic. To involve the patient on the basis of their clinical, biological and echocardiography data, in identifying the risk factors that need change. PATIENTS AND METHODS: From 2004 to 2014, heart failure with preserved systolic function (HF-PEF) has been diagnosed in 200 consecutive hypertensive patients (pts) at our Algerian outpatient unit...
June 2016: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26861937/association-of-ace-gene-d-polymorphism-with-left-ventricular-hypertrophy-in-patients-with-diastolic-heart-failure-a-case-control-study
#10
Ehsan Bahramali, Mona Rajabi, Javad Jamshidi, Seyyed Mohammad Mousavi, Mehrdad Zarghami, Alireza Manafi, Negar Firouzabadi
OBJECTIVES: To explore the association between ACE gene insertion/deletion (I/D) polymorphism with left ventricular hypertrophy (LVH) in patients with hypertension who have developed heart failure with preserved ejection fraction (HFpEF). Being a major contributor to the development of diastolic heart dysfunction, the renin angiotensin aldosterone system and its genetic variations are thought to induce LVH in hypertensive hearts apart from haemodynamic factors. DESIGN: Case control study...
February 9, 2016: BMJ Open
https://www.readbyqxmd.com/read/26698264/is-there-a-difference-in-mad-honey-poisoning-between-geriatric-and-non-geriatric-patient-groups
#11
COMPARATIVE STUDY
S Yaylacı, O Ayyıldız, E Aydın, A Osken, F Karahalil, C Varım, M V Demir, A B Genç, S Sahinkus, Y Can, İ Kocayigit, C Bilir
OBJECTIVE: This study aims to investigate the demographic, toxicological characteristics of the mad honey intoxication at ages 65 and above, to analyze the electrocardiographic parameters, and to compare with the mad honey intoxication at ages below 65 years. PATIENTS AND METHODS: Eighty-two patients, who had been treated and followed-up between June 2013 and November 2014 in the Emergency Service of the Findikli State Hospital, Turkey, due to diagnosis of mad honey intoxication, were included in our observational study...
December 2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/26242308/coronary-microvascular-function-is-independently-associated-with-left-ventricular-filling-pressure-in-patients-with-type-2-diabetes-mellitus
#12
Takayuki Kawata, Masao Daimon, Sakiko Miyazaki, Ryoko Ichikawa, Masaki Maruyama, Shuo-Ju Chiang, Chiharu Ito, Fumihiko Sato, Hirotaka Watada, Hiroyuki Daida
BACKGROUND: Left ventricular (LV) diastolic dysfunction is known as an early marker of myocardial alterations in patients with diabetes. Because microvascular disease has been regarded as an important cause of heart failure or diastolic dysfunction in diabetic patients, we tested the hypothesis that coronary flow reserve (CFR), which reflects coronary microvascular function, is associated with LV diastolic dysfunction in patients with type 2 diabetes. METHODS: We studied asymptomatic patients with type 2 diabetes but without overt heart failure...
August 5, 2015: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/26201429/good-at-heart-preserving-cardiac-metabolism-during-aging
#13
REVIEW
Daniela Sorriento, Antonietta Franco, Maria Rosaria Rusciano, Angela Serena Maione, Maria Soprano, Maddalena Illario, Guido Iaccarino, Michele Ciccarelli
The natural process of aging determinates several cardiac modifications with increased susceptibility to heart diseases and ultimately converging on development of chronic heart failure as final stage. These changes mainly include left ventricular hypertrophy, diastolic dysfunction, valvular degeneration, increased cardiac fibrosis, increased prevalence of atrial fibrillation, and decreased maximal exercise capacity, as demonstrated in several humans and animal models of aging. While different theories have been proposed to explain the natural process of aging, it is clear that most of the alterations affect mechanisms involved in cell homeostasis and maintenance...
2015: Current Diabetes Reviews
https://www.readbyqxmd.com/read/25972269/association-between-diastolic-dysfunction-and-future-atrial-fibrillation-in-the-troms%C3%A3-study-from-1994-to-2010
#14
Sweta Tiwari, Henrik Schirmer, Bjarne K Jacobsen, Laila A Hopstock, Audhild Nyrnes, Geir Heggelund, Inger Njølstad, Ellisiv B Mathiesen, Maja-Lisa Løchen
OBJECTIVE: To investigate the association between echocardiographic measurements with emphasis on diastolic dysfunction and risk of atrial fibrillation (AF) in a population-based cohort study. METHODS: We followed 2406 participants from the Tromsø Study from 1994 to 2010. Left atrial (LA) size and mitral Doppler indices as measured by echocardiography were used for evaluating diastolic dysfunction. Information concerning age, systolic blood pressure, height, heart rate, body mass index, total and high-density lipoprotein cholesterol, self-reported use of alcohol, smoking, coffee, physical activity, antihypertensive treatment, prevalent coronary heart disease, valvular heart disease, heart failure, hypertrophy, diabetes and palpitations were obtained at baseline...
August 2015: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/25727992/heart-failure-in-patients-with-atrial-fibrillation-in-europe-a-report-from-the-eurobservational-research-programme-pilot-survey-on-atrial-fibrillation
#15
Gregory Y H Lip, Cécile Laroche, Mircea I Popescu, Lars H Rasmussen, Laura Vitali-Serdoz, Gheorghe-Andrei Dan, Zbigniew Kalarus, Harry J G M Crijns, Mario M Oliveira, Luigi Tavazzi, Aldo P Maggioni, Giuseppe Boriani
AIMS: The purpose of this study was too describe the associated baseline features of AF patients with heart failure (HF) with reduced and preserved ejection fraction (HFrEF and HFpEF). Secondly, we assessed symptomatic status and their clinical correlates. Finally, we examined independent predictors for 'heart failure' at the 1-year follow-up period. METHODS AND RESULTS: A survey of European cardiologists from nine countries, participating in the EURObservational Research Programme Pilot survey on Atrial Fibrillation (EORP-AF Pilot), was carried out...
June 2015: European Journal of Heart Failure
https://www.readbyqxmd.com/read/25592109/ambulatory-arterial-stiffness-index-is-associated-with-impaired-left-atrial-mechanical-functions-in-hypertensive-diabetic-patients-a-speckle-tracking-study
#16
Ezgi Kalaycıoğlu, Tayyar Gökdeniz, Ahmet Çağrı Aykan, Engin Hatem, Ozan Mustafa Gürsoy, Gökhan Çavuşoğlu, Mustafa Çetin, Şükrü Çelik
OBJECTIVE: The ambulatory arterial stiffness index has been proposed as an indicator of arterial stiffness. The aim of this study was to test the hypothesis that increased ambulatory arterial stiffness index might be related with impaired left atrial function in hypertensive diabetic patients with no previous history of cardiovascular disease. METHODS: Inclusion criteria included office systolic BP> 130 mm Hg or diastolic BP> 80 mm Hg and absence of secondary causes of HT, whereas exclusion criteria LV ejection fraction <50%, history of significant coronary artery disease, chronic renal failure, atrial fibrillation/ flutter, second or third-degree atrioventricular block, moderate to severe valvular heart disease, history of cerebrovascular disease, non-dipper hypertensive pattern and sleep apnea...
October 2015: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/25547548/effects-of-sinus-rhythm-maintenance-on-left-heart-function-after-electrical-cardioversion-of-atrial-fibrillation-implications-for-tachycardia-induced-cardiomyopathy
#17
Andreas J Zimmermann, Matthias Bossard, Stefanie Aeschbacher, Tobias Schoen, Gian Voellmin, Yves Suter, Anouk Lehmann, Thomas Hochgruber, Katrin Pumpol, Christian Sticherling, Michael Kühne, David Conen, Beat A Kaufmann
BACKGROUND: The role of tachycardia-induced cardiomyopathy vs tachycardia-related short diastolic filling period and reduced atrial contraction in decline of left ventricular ejection fraction (LVEF) in atrial fibrillation (AF) is uncertain. We aimed to characterize left heart changes over time in patients with AF who undergo electrical cardioversion (ECV). METHODS: Consecutive AF patients who were to undergo ECV were enrolled. Patients with unstable or acute heart failure, severe valvular diseases, recent open-heart surgery, major disorders, or an unsuccessful ECV were excluded...
January 2015: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/24522082/early-subclinical-ventricular-dysfunction-in-patients-with-insulin-resistance
#18
Giuseppina Novo, Marinella Pugliesi, Claudia Visconti, Pietro Spatafora, Marianna Fiore, Riccardo Di Miceli, Francesco Paolo Guarneri, Giustina Vitale, Salvatore Novo
AIMS: The aim of our study was to evaluate the relationship between insulin resistance and the detection of precocious echocardiographic signs of heart failure in patients with cardiovascular risk factors. METHODS: We enrolled 34 consecutive patients with cardiovascular risk factors. All patients underwent coronary angiography, echocardiography, and laboratory tests. Exclusion criteria were diabetes (fasting glucose greater than 126 mg/dl or treatment with insulin or oral hypoglycemic agents), coronary artery disease, creatinine above 1...
February 2014: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/22229339/cardiac-aging-from-molecular-mechanisms-to-significance-in-human-health-and-disease
#19
REVIEW
Dao-Fu Dai, Tony Chen, Simon C Johnson, Hazel Szeto, Peter S Rabinovitch
Cardiovascular diseases (CVDs) are the major causes of death in the western world. The incidence of cardiovascular disease as well as the rate of cardiovascular mortality and morbidity increase exponentially in the elderly population, suggesting that age per se is a major risk factor of CVDs. The physiologic changes of human cardiac aging mainly include left ventricular hypertrophy, diastolic dysfunction, valvular degeneration, increased cardiac fibrosis, increased prevalence of atrial fibrillation, and decreased maximal exercise capacity...
June 15, 2012: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/22051334/mechanical-stretch-of-atrial-myocyte-monolayer-decreases-sarcoplasmic-reticulum-calcium-adenosine-triphosphatase-expression-and-increases-susceptibility-to-repolarization-alternans
#20
Chia-Ti Tsai, Fu-Tien Chiang, Chuen-Den Tseng, Chih-Chieh Yu, Yi-Chih Wang, Ling-Ping Lai, Juey-Jen Hwang, Jiunn-Lee Lin
OBJECTIVES: The purpose of this study was to investigate the effect of stretch (the major risk factor for atrial fibrillation [AF]) on spatial and temporal alternations of action potential duration (APD-ALT) and calcium transient in cultured atrial myocyte monolayer. BACKGROUND: How rapid firings or premature beats trigger AF is not completely understood. Discordant repolarization alternans, characterized by simultaneous prolongation and shortening of APD in different myocardial regions, is central to the genesis of ventricular fibrillation...
November 8, 2011: Journal of the American College of Cardiology
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