keyword
https://read.qxmd.com/read/38529182/shotgun-metagenomics-reveals-the-gut-microbial-diversity-and-functions-in-vespa-mandarinia-hymenoptera-vespidae-at-multiple-life-stages
#21
JOURNAL ARTICLE
Peng-Kai Yin, Huai Xiao, Zhi-Bin Yang, Da-Song Yang, Yin-He Yang
Wasps play important roles as predators and pollinators in the ecosystem. The Jingpo minority residing in Yunnan Province, China, has a traditional practice of using wine infused with mature wasps as a customary remedy for managing rheumatoid arthritis. The larva of the wasp is also a tasteful folk dish that has created a tremendous market. There is a paucity of survival knowledge, which has greatly restricted their potential applications in food and healthcare. Recent research has highlighted the importance of gut microbiota in insect growth...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38529117/retention-rate-of-biologic-and-targeted-synthetic-anti-rheumatic-drugs-in-elderly-rheumatoid-arthritis-patients-data-from-gisea-registry
#22
JOURNAL ARTICLE
Andreina Manfredi, Marco Fornaro, Chiara Bazzani, Simone Perniola, Alberto Cauli, Alessandra Rai, Ennio Giulio Favalli, Serena Bugatti, Maurizio Rossini, Rosario Foti, Fabrizio Conti, Giuseppe Lopalco, Anna Scalvini, Cristina Garufi, Mattia Congia, Roberto Gorla, Elisa Gremese, Fabiola Atzeni, Roberto Caporali, Florenzo Iannone, Marco Sebastiani
OBJECTIVES: An increased number of elderly individuals affected by rheumatoid arthritis (RA) has been reported, including both patients with RA onset in advanced age and patients aged with the disease. In this registry-based study, we aimed to analyze the retention rate and cause of discontinuation of biologic (b) and targeted synthetic (ts)-disease-modifying anti-rheumatic drugs (DMARDs) in RA patients over 65 year old. METHODS: RA patients enrolled in the Italian GISEA registry and starting a b- or a ts-DMARD over 65 years of age were included...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38528940/risk-of-primary-gastrointestinal-lymphoma-in-patients-with-inflammatory-conditions-exposed-to-tumor-necrosis-factor-alpha-inhibitors-and-immunomodulators-a-case-control-study
#23
JOURNAL ARTICLE
Manuel B Braga-Neto, Jason Nasser, Xiao Xing Iris Wang, William Scott Harmsen, Laura E Raffals, Michael Camilleri, Victor Chedid
INTRODUCTION: The aim of this case-control study was to determine if exposure to tumor necrosis factor alpha inhibitors (TNFIs) or immunomodulators (thiopurines or methotrexate) was associated with development of primary gastrointestinal lymphoma (PGIL) in patients with chronic inflammatory conditions. METHODS: Patients with PGIL and controls evaluated at a tertiary care center over 20 years were matched 1:3 using a medical record informatics search engine based on their chronic inflammatory condition (Crohn's disease [CD], ulcerative colitis [UC], rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis) and duration of follow-up...
January 2024: Crohn's & colitis 360
https://read.qxmd.com/read/38528553/extracorporeal-photopheresis-reduces-inflammation-and-joint-damage-in-a-rheumatoid-arthritis-murine-model
#24
JOURNAL ARTICLE
Yuwei Lin, Zhanrui Cheng, Yan Zhong, Yinting Zhao, Guifen Xiang, Ling Li, Li Tian, Zhong Liu
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammatory reactions and tissue damage in the joints. Long-term drug use in clinical practice is often accompanied by adverse reactions. Extracorporeal photopheresis (ECP) is an immunomodulatory therapy with few side effects, offering a potential and safe therapeutic alternative for RA through the induction of immune tolerance. This study aimed to investigate the therapeutic effects of ECP on RA using a collagen-induced arthritis (CIA) murine model, as well as to explore its immunomodulatory effects in vivo...
March 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38528307/pathophysiology-diagnosis-and-herbal-medicine-based-therapeutic-implication-of-rheumatoid-arthritis-an-overview
#25
REVIEW
Charanjit Kaur, Yachana Mishra, Rajesh Kumar, Gurvinder Singh, Sukhraj Singh, Vijay Mishra, Murtaza M Tambuwala
Rheumatoid arthritis (RA) stands as an autoimmune disorder characterized by chronic joint inflammation, resulting in profound physiological alterations within the body. Affecting approximately 0.4-1.3% of the global population, this condition poses significant challenges as current therapeutic approaches primarily offer symptomatic relief, with the prospect of complete recovery remaining elusive. This review delves into the contemporary advancements in understanding the pathophysiology, diagnosis, and the therapeutic potential of herbal medicine in managing RA...
March 25, 2024: Inflammopharmacology
https://read.qxmd.com/read/38528207/macrophage-re-programming-by-jak-inhibitors-relies-on-mafb
#26
JOURNAL ARTICLE
Baltasar López-Navarro, Miriam Simón-Fuentes, Israel Ríos, María Teresa Schiaffino, Alicia Sanchez, Mónica Torres-Torresano, Alicia Nieto-Valle, Isabel Castrejón, Amaya Puig-Kröger
Monocyte-derived macrophages play a key pathogenic role in inflammatory diseases. In the case of rheumatoid arthritis (RA), the presence of specific synovial tissue-infiltrating macrophage subsets is associated with either active disease or inflammation resolution. JAK inhibitors (JAKi) are the first targeted synthetic disease-modifying antirheumatic drugs (tsDMARD) approved for treatment of RA with comparable efficacy to biologics. However, the effects of JAKi on macrophage specification and differentiation are currently unknown...
March 25, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38526615/ninety-day-postoperative-mortality-and-complications-in-continuous-and-unselected-single-stage-revisions-for-chronic-periprosthetic-joint-infection
#27
JOURNAL ARTICLE
Chenchen Yang, Baochao Ji, Guoqing Li, Xiaogang Zhang, Boyong Xu, Li Cao
PURPOSE: Single-stage revision has gained significant attention as a major surgical approach for periprosthetic joint infection (PJI). However, the 90-day mortality and complication profile of single-stage revision is poorly characterized. The purposes of this study were to determine the incidence rates of and identify the risk factors for 90-day postoperative mortality and complications of single-stage revision for chronic PJI. METHODS: A retrospective review was conducted on patients who underwent single-stage revision for PJI between August 2000 and May 2022...
March 25, 2024: International Orthopaedics
https://read.qxmd.com/read/38526004/a-large-cohort-comparison-of-very-late-onset-systemic-lupus-erythematosus-with-younger-onset-patients
#28
JOURNAL ARTICLE
Luisa Viveiros, Ana Neves, Teresa Gouveia, David A Isenberg
OBJECTIVES: Age has a significant impact on systemic lupus erythematosus (SLE). However, data on very late-onset SLE (vlSLE) are scarce. We have compared the clinical and serological features of vlSLE patients with younger-onset patients. METHODS: We assessed the clinical and laboratory data of all patients fulfilling SLE classification criteria evaluated at a university hospital from 1978 to 2023. Patients were divided into 4 groups according to age at diagnosis: juvenile SLE (jSLE <8 years); adult SLE (aSLE 18-49 years); late SLE (lSLE 50-59 years); vlSLE (≥60 years)...
March 19, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38525998/elevated-das28-esr-in-patients-with-rheumatoid-arthritis-who-have-comorbid-fibromyalgia-is-associated-more-with-tender-joint-counts-than-with-patient-global-assessment-or-swollen-joint-counts-implications-for-assessment-of-inflammatory-activity
#29
JOURNAL ARTICLE
Sandhya Kannayiram, Juan Schmukler, Tengfei Li, Nicola Goodson, Aarthi Sridhar, Theodore Pincus
OBJECTIVES: More than 20% of rheumatoid arthritis (RA) patients have comorbid fibromyalgia (FM+), which may elevate DAS28-ESR (disease activity score 28-erythrocyte sedimentation rate) and other indices, resulting in challenges to assess inflammatory disease activity. Although several reports indicate that elevated patient global assessment (PATGL) may elevate DAS28 in the absence of inflammatory activity, less information is available concerning the other three components, tender joint count (TJC), swollen joint count (SJC), and erythrocyte sedimentation rate (ESR), to possibly elevate DAS28 in FM+ vs...
March 22, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38525928/phytotherapeutic-potential-of-compounds-identified-from-fractionated-extracts-of-morus-alba-l-as-an-inhibitor-of-interleukin-6-in-the-treatment-of-rheumatoid-arthritis-computational-approach
#30
JOURNAL ARTICLE
Tran Nhat Phong Dao, Sunday Amos Onikanni, Adewale Oluwaseun Fadaka, Nicole Remaliah Samantha Sibuyi, Minh Hoang Le, Hen-Hong Chang
The presence of HLA-DRB1 alleles that encode critical points associated with environmental interactions is associated with increased risk of rheumatoid arthritis caused by anti-citrullinated protein antibodies. Therefore, interleukin-6 (IL-6), a multifunctional cytokine that controls both local and systemic acute inflammatory responses through its ability to induce a phase response, plays a serious role. Its overexpression leads to pathological challenges such as rheumatoid arthritis and menopausal osteoporosis...
March 25, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38524267/can-we-achieve-pain-stratification-in-musculoskeletal-conditions-implications-for-clinical-practice
#31
REVIEW
Nidhi Sofat, Andrew Lambarth
In the last few years there has been an increased appreciation that pain perception in rheumatic and musculoskeletal diseases (RMDs) has several mechanisms which include nociceptive, inflammatory, nociplastic and neuropathic components. Studies in specific patient groups have also demonstrated that the pain experienced by people with specific diagnoses can present with distinctive components over time. For example, the pain observed in rheumatoid arthritis has been widely accepted to be caused by the activation of nociceptors, potentiated by the release of inflammatory mediators, including prostaglandins, leukotrienes and cytokine networks in the joint environment...
2024: Front Pain Res (Lausanne)
https://read.qxmd.com/read/38524110/acute-methotrexate-toxicity-in-a-patient-with-psoriasis-a-case-report
#32
Hind Abouzahir, Ahmed Belhouss, Hicham Benyaich
Aside from rheumatoid arthritis, methotrexate is also used to treat cancer, psoriasis, and other diseases. Side effects with methotrexate are possible, as they are with any medication. This drug is extremely potent and has the potential to produce serious adverse effects. Those who use this medication need to be tracked often. We provide a case of a patient with psoriasis vulgaris who died due to methotrexate administration without proper dosage verification. A female patient in her forties had a history of psoriasis vulgaris of the lower limbs...
2024: Pan African Medical Journal
https://read.qxmd.com/read/38524108/-rheumatoid-arthritis-remission-without-biotherapy-the-experience-of-burkina-faso-west-africa
#33
JOURNAL ARTICLE
Aboubakar Ouédraogo, Fulgence Kabore, Wendlasida Joëlle Stéphanie Zabsonré/Tiendrebéogo, Victor Nonguierma, Binta Savadogo, Kantiga Aida Eudoxie Abassiri, Yamyellé Enselme Zongo, Richard Damade, Dieu-Donné Ouédraogo
INTRODUCTION: the objective of this study was to evaluate the therapeutic response of patients treated with disease-modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis (RA). METHODS: descriptive and analytical single-center cross-sectional study conducted in Burkina Faso from January 2019 to December 2021 in patients with RA meeting American Rheumatism Association/European League against rheumatism criteria. Therapeutic response was assessed according to the criteria of the European League Against Rheumatism, the clinical disease activity index and the simplified disease activity Index after at least six months of treatment...
2024: Pan African Medical Journal
https://read.qxmd.com/read/38524092/varicella-zoster-meningitis-and-myelitis-after-herpes-zoster-dermatitis-treatment-with-amenamevir-a-case-series-and-literature-review
#34
Satoru Tada, Yuta Kaito, Akihiro Watanabe, Yukio Sugiyama, Akira Nishigaichi, Takashi Miwa, Kotaro Watanabe, Takanori Hazama, Daisuke Takahashi
Varicella-zoster virus (VZV), known for causing chickenpox, establishes latent infections in neural tissues. Reactivation of VZV can lead to herpes zoster (HZ) and various neurological complications. In this report, we present four cases of VZV meningitis and myelitis following amenamevir treatment for HZ dermatitis with positive VZV DNA in cerebrospinal fluid (CSF) revealed by polymerase chain reaction (PCR). Three of them were considered immunocompromised hosts given the fact that two of these patients were taking immunosuppressive drugs for rheumatoid arthritis, and one patient had a history of sigmoid colon cancer (four months after resection)...
February 2024: Curēus
https://read.qxmd.com/read/38523940/an-unusual-case-of-non-typhoidal-salmonella-bacteremia-causing-life-threatening-aortitis
#35
Fawwad A Ansari, Stefan Gafoor, Mubashira Aftab, Zola Nlandu
Non-typhoidal Salmonella typically presents with gastroenteritis. However, an invasive Salmonella infection, which may be typically seen in immunocompromised patients, has a propensity for aortic involvement, especially in patients with risk factors for atherosclerosis. Here we present a 60-year-old female with multiple comorbid conditions and currently on immunosuppressants for rheumatoid arthritis, who presented with nausea, vomiting, and fever of three weeks duration and was found to have Salmonella bacteremia...
February 2024: Curēus
https://read.qxmd.com/read/38523896/a-rare-case-of-acute-methotrexate-toxicity-leading-to-bone-marrow-suppression
#36
Samreen Khuwaja, Matthew Lyons, Beenish Zulfiqar
Methotrexate is a first-line disease modifying antirheumatic drug used for the treatment of inflammatory arthritis. Bone marrow suppression is a common adverse reaction of methotrexate following its long-term use. However, low dose methotrexate is rarely associated with life-threatening bone marrow suppression. This case represents an atypical presentation of acute bone marrow suppression shortly after initiating treatment with low-dose methotrexate. A 76-year-old male patient presented with oral ulcers, poor oral intake, and acute kidney injury within 3 weeks of initiating 15 mg weekly of methotrexate for seronegative rheumatoid arthritis...
2024: Case Reports in Rheumatology
https://read.qxmd.com/read/38523723/methotrexate-toxicity-complicating-a-case-of-rheumatoid-arthritis-associated-interstitial-lung-disease-lessons-to-learn
#37
H Ikrou, M Salek, S Boustani, W Bouissar, S Wakrim, S Abdala, H Serhane
Rheumatoid arthritis (RA) is one of the most common types of autoimmune arthritis. It can also involve other organs, including vascular structures, and lungs which are affected in 60% to 80% of cases. Other complications may present as airway infections and drug related pulmonary toxicity. We present the case of 75-year-old male patient of North African decent that was hospitalized initially for chronic dyspnea associated with other systemic manifestations, and in whom we confirmed the diagnosis of Rheumatoid arthritis associated interstitial lung disease...
June 2024: Radiology Case Reports
https://read.qxmd.com/read/38523584/evaluation-of-diagnostic-and-therapeutic-delay-in-patients-with-rheumatoid-arthritis-and-psoriatic-arthritis
#38
JOURNAL ARTICLE
M Iacovantuono, S Ferrigno, P Conigliaro, P Triggianese, A D'Antonio, F R Spinelli, A Bergamini, M S Chimenti
OBJECTIVE: A monocentric cross-sectional study recruiting rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients residing in the Lazio region, Italy, to assess factors related to diagnostic delay and treatment accessibility. METHODS: Clinical/serological data, including the time between symptom onset, diagnosis, and the beginning of treatment, were collected. Residence, referral to a rheumatologic center, physician who made the diagnosis, and previous misdiagnosis were also evaluated...
March 22, 2024: Reumatismo
https://read.qxmd.com/read/38523562/incident-use-of-hydroxychloroquine-for-the-treatment-of-rheumatoid-arthritis-and-systemic-lupus-erythematosus-during-the-covid-19-pandemic
#39
JOURNAL ARTICLE
Núria Mercadé-Besora, Yuchen Guo, Mike Du, Xintong Li, Juan Manuel Ramírez-Anguita, Alberto Moreno, António Valente, Felipe Villalobos, Iek Leng Cheng, Lucía A Carrasco-Ribelles, Maaike Mh van Swieten, Manon Merkelbach, Mary Magoya, Paolo Lasalvia, Pau Pericàs Pulido, Paul Berg, Pauline Bosco-Lévy, Roberto Lillini, Rogerio Ribeiro, Trinamjot Kaur Bagga, Vittoria Ramella, Sara Khalid, Miguel Angel Mayer, Angela Leis, Annika M Jödicke, Edward Burn, Daniel Prieto-Alhambra, Martí Català, Albert Prats-Uribe
OBJECTIVE: We studied whether the use of hydroxychloroquine (HCQ) for COVID-19 resulted in supply shortages for patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). METHODS: We used US claims data (IQVIA PHARMETRICS® Plus for Academics [PHARMETRICS]) and hospital electronic records from Spain (IMASIS) to estimate monthly rates of HCQ use between January 2019 and March 2022, in the general population, and in RA and SLE patients. Methotrexate (MTX) was use was estimated as a control...
March 25, 2024: Arthritis Care & Research
https://read.qxmd.com/read/38523516/synthesis-and-in-vitro-and-silico-anti-inflammatory-activity-of-new-thiazolidinedione-quinoline-derivatives
#40
JOURNAL ARTICLE
Sandra Elizabeth Barbosa da Silva, José Arion da Silva Moura, Jeann Fabiann Branco Júnior, Paulo André Teixeira de Moraes Gomes, Simão Kalebe Silva de Paula, Douglas Carvalho Francisco Viana, Eduardo Augusto Vasconcelos de Freitas Ramalho, João Victor de Melo Gomes, Michelly Cristiny Pereira, Maira Galdino da Rocha Pitta, Ivan da Rocha Pitta, Marina Galdino da Rocha Pitta
BACKGROUND: Inflammation is a series of complex defense-related reactions. The inflammation cascade produces various pro-inflammatory mediators. Unregulated production of these pro-inflammatory mediators can lead to a wide range of diseases, including rheumatoid arthritis, sepsis, and inflammatory bowel disease. In the literature, the anti-inflammatory action of quinoline and thiazolidinedione nuclei are well established, alone, and associated with other nuclei. The synthesis of hybrid molecules is a strategy for obtaining more efficient molecules due to the union of pharmacophoric nuclei known to be related to pharmacological activity...
March 21, 2024: Current Topics in Medicinal Chemistry
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