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"Rheumatoid Arthritis"

Saurav Islam, Shruti Shukla, Vivek K Bajpai, Young-Kyu Han, Yun Suk Huh, Ashok Kumar, Arindam Ghosh, Sonu Gandhi
Human immunodeficiency virus (HIV), which isa worldwide public health issue, is commonly associated with cardiovascular disorders (CVDs) and rheumatoid arthritis (RA). A smart nanosensor was developed for the detection of HIV and its related diseases (CVDs and RA) using graphene-based field-effect transistors (FETs). In this study, amine-functionalized graphene (afG) was conjugated with antibodies [anti-p24 for HIV, anti-cardiac troponin 1 (anti-cTn1) for CVDs, and anti-cyclic citrullinated peptide (anti-CCP) for RA] to detect various biomarkers...
December 7, 2018: Biosensors & Bioelectronics
Diana Rocio Herrera-Aco, Omar Noel Medina-Campos, José Pedraza-Chaverri, Edda Sciutto-Conde, Gabriela Rosas-Salgado, Gladis Fragoso-González
Rheumatoid arthritis (RA) is an autoimmune disease that causes physical disability in people worldwide. Despite progress made in RA treatment in the past decade, new drugs with high efficacy but few long-term adverse effects are still needed. This study focused on evaluating the therapeutic potential of α-mangostin on established collagen-induced arthritis (CIA) in DBA/1J mice. Arthritic DBA/1J mice were orally administered with two doses of α-mangostin (10 and 40 mg/kg) daily, for 33 days. Alpha-mangostin significantly decreased the clinical score in the short term at both doses and decreased the histopathological score at the higher dose...
December 14, 2018: Food and Chemical Toxicology
Asuncion Martinez-Anton, Delphine Gras, Arnaud Bourdin, Patrice Dubreuil, Pascal Chanez
KIT is a receptor tyrosine kinase that after binding to its ligand stem cell factor activates signaling cascades linked to biological processes such as proliferation, differentiation, migration and cell survival. Based on studies performed on SCF and/or KIT mutant animals that presented anemia, sterility, and/or pigmentation disorders, KIT signaling was mainly considered to be involved in the regulation of hematopoiesis, gametogenesis, and melanogenesis. More recently, novel animal models and ameliorated cellular and molecular techniques have led to the discovery of a widen repertoire of tissue compartments and functions that are being modulated by KIT...
December 14, 2018: Pharmacology & Therapeutics
Sandra Haider, Igor Grabovac, Carolin Berner, Thomas Lamprecht, Karl-Heinrich Fenzl, Ludwig Erlacher, Michael Quittan, Thomas E Dorner
OBJECTIVES: The prevalence of frailty has been widely researched in the elderly population. However, data about people of working age are scarce. The aim of this paper was to assess the prevalence of prefrailty and frailty in rheumatoid arthritis (RA) patients of working age, and to assess factors associated with prefrailty/frailty. METHODS: In this monocentric cross-sectional study, 100 RA patients aged 18-65 years were included. Frailty was measured with the Frailty Instrument for Primary Care of the Survey of Health, Ageing and Retirement in Europe (SHARE-FI) and disease activity with the Clinical Disease Activity Index (CDAI)...
November 19, 2018: Clinical and Experimental Rheumatology
Georg Pongratz, Torsten Lowin, Philipp Sewerin, Frank Zaucke, Zsuzsa Jenei-Lanzl, Thomas Pauly, Benedikt Ostendorf, Matthias Schneider
OBJECTIVES: Tryptophan and its metabolites have been suggested to play a role in inflammatory processes. However, studies in rheumatoid arthritis (RA) are scarce, which prompted us to investigate two cohorts of RA patients to better understand the importance of tryptophan metabolism in this disease. METHODS: Tryptophan and its metabolites were characterised by ELISA in a cross-sectional cohort 1 (81 RA, 55 OA) and a longitudinal cohort 2 (25 RA, 3 visits over 6 months) to investigate discriminatory power between diseases and predicitive value for radiologic outcome, respectively...
November 16, 2018: Clinical and Experimental Rheumatology
Ombretta Di Munno, Francesco Ferro
Osteoporosis (OP) and increased fracture risk are widely observed comorbidities in chronic inflammatory rheumatic diseases (CIRDs). Improved knowledge of the immune/inflammatory pathways, which characterise the pathophysiology of rheumatoid arthritis (RA) and seronegative spondyloarthropathies (SpA), such as ankylosing spondylitis (AS) and psoriatic arthritis (PsA), have provided the link between inflammation and bone loss, via a complex network of bone cells, T and B cells, pro-inflammatory cytokines such as TNF-α, IL1, IL6, IL17, IL23, costimulator molecules, signalling pathways including both RANKL/RANK/OPG and Wnt signallings...
November 19, 2018: Clinical and Experimental Rheumatology
Seung Up Kim, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Yong-Beom Park, Kwang-Hyub Han, Sang-Won Lee
Objectives Comorbidities and conventional risk factors influence the prognosis of patients with rheumatoid arthritis (RA). We investigated whether liver fibrosis burden is associated with all-cause mortality in patients with RA. Methods A total of 2812 patients with RA were retrospectively selected and reviewed. Liver fibrosis was assessed using the fibrosis-4 index (FIB-4) [age (years)× aspartate aminotransferase level (IU/L)/platelet count (109 /L)/√alanine aminotransferase (IU/L)]. Results The mean patient age was 51...
December 17, 2018: Modern Rheumatology
Casandra Buzatu, Robert J Moots
Effective treatment of rheumatoid arthritis (RA) requires suppression of the underlying inflammation. Measurement of such inflammation, the disease activity, is mandatory to target treatment and maximize outcomes. However, this is not as straightforward as it may seem. Areas covered: The many tools developed to measure disease activity in RA, from composite scores and patient reported outcomes, to laboratory markers and imaging are discussed, with a focus on their utility in guiding therapy and assessing response...
December 17, 2018: Expert Review of Clinical Immunology
María Reina-Bueno, María Del Carmen Vázquez-Bautista, Sergio Pérez-García, Carolina Rosende-Bautista, Antonia Sáez-Díaz, Pedro V Munuera-Martínez
OBJECTIVE: To determine the effect of custom-made foot orthoses versus placebo insoles on pain, disability, foot functionality, and quality of life. DESIGN: Double-blinded randomized controlled trial. SETTING: University Podiatric Clinical Area. SUBJECTS: Patients with rheumatoid arthritis. INTERVENTIONS: Patients were randomly assigned to either group A, which received custom-made foot orthoses, or group B, which received placebo, flat cushioning insoles, for three months...
December 17, 2018: Clinical Rehabilitation
Marina I Arleevskaya, Shafigullina Albina, Regina V Larionova, Aida G Gabdoulkhakova, Julie Lemerle, Yves Renaudineau
Introduction: The aim of this study was to characterize infection events in a longitudinal cohort of first-degree relatives (FDR) of probands with rheumatoid arthritis (RA) and explore their associations with RA development. To this end, newly diagnosed RA patients ( n = 283), unaffected related FDR and age-matched healthy women were ascertained from the Caucasian triple women prospective Tatarstan cohort. Methods: In this cohort initiated in 1997, 26/283 (9.2%) FDR developed RA (incidence: 9.1 cases/1,000/year)...
2018: Frontiers in Immunology
Jennifer R Richardson, Nicole S Armbruster, Manina Günter, Jörg Henes, Stella E Autenrieth
Staphylococcus aureus (Sa), as one of the major human pathogens, has very effective strategies to subvert the human immune system. Virulence of the emerging community-associated methicillin-resistant Sa (CA-MRSA) depends on the secretion of phenol-soluble modulin (PSM) peptide toxins e.g., by binding to and modulation of innate immune cells. Previously, by using mouse bone marrow-derived dendritic cells we demonstrated that PSMs in combination with various Toll-like receptor (TLR) ligands induce a tolerogenic DC phenotype (tDC) characterized by the production of IL-10 and impaired secretion of pro-inflammatory cytokines...
2018: Frontiers in Immunology
Xiaoyang Yao, Miao Xue, Tiejun Gui, Chenyun Ma, Xiudi Jiang, Hongli Yan
Objective To develope a chemiluminescence immunoassay based on microarray protein chip technology for detecting the anti-carbamylated protein (CarP) antibody. We aimed to evaluate the detection performance of this method and to explore its preliminary clinical application value of this index in patients with rheumatoid arthritis (RA). Methods A quantitative detection method for anti-CarP antibody was established to evaluate the precision, minimum detection limit, linear range and specificity of the method. The 95th position of anti-CarP antibody level in serum of 120 healthy controls was defined as the cutoff value...
October 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
Seung Min Jung, Youngkyun Kim, Juryun Kim, Hyerin Jung, Hyoju Yi, Yeri Alice Rim, Narae Park, Seung Ki Kwok, Sung Hwan Park, Ji Hyeon Ju
PURPOSE: Sodium chloride (NaCl) has been proposed as a driving factor in autoimmune diseases through the induction of pathogenic CD4+ T helper cells that produce interleukin-17 (Th17 cells). This study investigated the effects of NaCl on inflammatory arthritis in mice and humans. MATERIALS AND METHODS: Collagen-induced arthritis (CIA) mice were fed a normal or high-salt diet ad libitum , and clinical and histologic features of arthritis were evaluated. The proportion of Th17 cells in the spleens of CIA mice fed a normal or high-salt diet was evaluated by flow cytometry, and the expression of IL-17 in joints and intestines was determined by immunohistochemical staining...
January 2019: Yonsei Medical Journal
G Elia
Monokine induced by interferon (IFN)-γ (MIG) / chemokine (C-X-C motif) ligand 9 (CXCL)9 is involved in the pathogenesis of psoriatic arthritis (PsA). It was demonstrated that both blood plasma-derived dendritic cells (pDCs) and pDCs isolated from rheumatoid arthritis (RA) and PsA synovial fluid (SF), expressed CXC receptor (R) 3 and CXCR4, and that the chemotaxis of blood-derived pDCs is stimulated by MIG, (IFN)-γ-inducible protein 10 (IP-10)/CXCL10, IFN-inducible T-cell α chemoattractant (I-TAC) )/CXCL11 and stromal cell-derived factor 1 (SDF-1)/ CXCL12, present in RA and PsA SF...
November 2018: La Clinica Terapeutica
Chaohong Li, Songlou Yin, Hanqiu Yin, Lina Cao, Ting Zhang, Yong Wang
BACKGROUND Calcitriol (1 alpha, 25-dihydroxy vitamin D3) is a good vitamin D supplement but can cause hypercalcemia. Whereas, 22-oxa-1 alpha, 25-dihydroxy vitamin D3 (22-oxa-calcitriol) has less hypercalcemic activity than calcitriol and is reported to be effective for cell-proliferative diseases. The objective of the study was to compare renal function and blood tests of arthritis patients receiving calcitriol supplements with those receiving 22-oxa-calcitriol supplements. MATERIAL AND METHODS A total of 369 patients with clinically confirmed rheumatoid arthritis were included in this phase II trial...
December 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Anniek M van Roon, Cato C Huisman, Arie M van Roon, Dan Zhang, Alja J Stel, Andries J Smit, Hendrika Bootsma, Douwe J Mulder
OBJECTIVE: To assess the presence of a systemic sclerosis (SSc) pattern on nailfold capillary microscopy (NCM) in patients with Raynaud phenomenon (RP) and to explore its association with abnormal pulmonary function tests (PFT). METHODS: NCM patterns were assessed in 759 consecutive patients with RP. Patterns were classified as normal (n = 354), nonspecific (n = 159), or SSc pattern (n = 246). Abnormal PFT was defined as forced vital or diffusion capacity < 70%...
December 15, 2018: Journal of Rheumatology
Nan Li, Zhaohui Gong, Xiaojuan Li, Qingyu Ma, Mansi Wu, Dongdong Liu, Lijuan Deng, Dongmei Pan, Qingping Liu, Zhenquan Wei, Qiang Wang, Longyin Han, Changsong Lin, Jiaxu Chen
The aggressive phenotype displayed by fibroblast-like synoviocytes (FLSs) contributes to cartilage and bone destruction in rheumatoid arthritis (RA). Betulinic acid has been demonstrated to have a positive therapeutic effect on tumor, inflammation and immune disorder, however, the effects of betulinic acid on RA FLSs have not been verified. Therefore, in the present study, we observed the effect of betulinic acid on the migration and invasion of RA FLSs and explored its underlying signal mechanisms. Our results showed that betulinic acid treatment suppressed the migration, invasion and reorganization of the actin cytoskeleton of RA FLSs...
December 13, 2018: International Immunopharmacology
Chen-Chung Liao, Yu-Sheng Chang, Chao-Wen Cheng, Wei-Ming Chi, Kai-Leun Tsai, Wei-Jung Chen, Ting-Shuan Kung, Chih-Chun Tai, Yi-Fang Lin, Hung-Tse Lin, Yi-Ying Lu, Ching-Yu Lin
No abstract text is available yet for this article.
December 12, 2018: Journal of Proteomics
Nataly Simões Bandiera Thimóteo, Tatiana Mayumi Veiga Iryioda, Daniela Frizon Alfieri, Brunna Emanuella França Rego, Bruna Miglioranza Scavuzzi, Elis Fatel, Marcell Alysson Batisti Lozovoy, Andréa Name Colado Simão, Isaias Dichi
OBJECTIVES: Studies have shown that cranberry (Vaccinium macrocarpon) has antiinflammatory and antioxidant effects; however, to our knowledge, the effects of cranberry juice consumption have not been studied in patients with rheumatoid arthritis (RA). The aim of this study was to verify the effect of cranberry juice consumption on several inflammatory biomarkers and on the disease activity of patients with RA. METHODS: A prospective study was conducted with 41 women diagnosed with RA...
October 10, 2018: Nutrition
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