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"Rheumatoid Arthritis"

Lahunlang Sohliya, John Mathew, G Ishitha, Jyoti Panwar, Korula Mani Jacob
Rheumatoid Arthritis can present with consistent pain over peripheral joints. The manner of presentation of a subcutaneous tumour such as Myopericytoma may be very similar to that of an inflamed joint leading to the high frequency of it being overlooked and inadequately treated. Knowing the radiological and pathological differences will direct us in the right road to timely and adequate treatment.
March 2018: Journal of the Association of Physicians of India
Chen Yu, Shangyi Jin, Yanhong Wang, Nan Jiang, Chanyuan Wu, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng
This systematic review and meta-analysis aim to evaluate the remission rate of patients with rheumatoid arthritis (RA) in real-world studies and to summarize potential predictors of remission in RA. Studies reporting remission rate in patients with RA were searched from MEDLINE, EMBASE, and Scopus databases. Two reviewers independently assessed all studies according to eligibility criteria and extracted data. Generally, observational studies reporting remission rate in adult (≥ 18 years) patients with RA were included...
October 19, 2018: Clinical Rheumatology
Chi Zhang, Li Li, Ge Zhang, Ke-Ji Chen, Ai-Ping Lu
Biological complexity and the need for personalized medicine means that biomarker development has become increasingly challenging. Thus, new paradigms for research need to be created that bring together a different classifier of individuals. One potential solution is collaboration between biomarker development and Chinese medicine pattern classification. In this article, two examples of rheumatoid arthritis are discussed, including a new biomarker candidate casein kinase 2 interacting protein 1 (CKIP-1) and a micro RNA 214...
October 19, 2018: Chinese Journal of Integrative Medicine
Vivian P Bykerk, Gerd R Burmester, Bernard G Combe, Daniel E Furst, Tom W J Huizinga, Harris A Ahmad, Paul Emery
Clinical outcomes in patients with early rheumatoid arthritis (RA) were assessed by baseline symptom duration in the Assessing Very Early Rheumatoid arthritis Treatment trial (; NCT01142726). Patients with early, active RA were randomized to subcutaneous (SC) abatacept 125 mg/week plus methotrexate (MTX), SC abatacept alone, or MTX monotherapy for 12 months. All RA treatments were withdrawn after 12 months in patients with Disease Activity Score in 28 joints (C-reactive protein; DAS28-CRP) < 3...
October 20, 2018: Rheumatology International
Zhu Chen, Aline Bozec, Andreas Ramming, Georg Schett
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a failure of spontaneous resolution of inflammation. Although the pro-inflammatory cytokines and mediators that trigger RA have been the focus of intense investigations, the regulatory and anti-inflammatory cytokines responsible for the suppression and resolution of disease in a context-dependent manner have been less well characterized. However, knowledge of the pathways that control the suppression and resolution of inflammation in RA is clinically relevant and conceptually important for understanding the pathophysiology of the disease and for the development of treatments that enable long-term remission...
October 19, 2018: Nature Reviews. Rheumatology
Xiang Zhu, Matthew Stephens
Genome-wide association studies (GWAS) aim to identify genetic factors associated with phenotypes. Standard analyses test variants for associations individually. However, variant-level associations are hard to identify and can be difficult to interpret biologically. Enrichment analyses help address both problems by targeting sets of biologically related variants. Here we introduce a new model-based enrichment method that requires only GWAS summary statistics. Applying this method to interrogate 4,026 gene sets in 31 human phenotypes identifies many previously-unreported enrichments, including enrichments of endochondral ossification pathway for height, NFAT-dependent transcription pathway for rheumatoid arthritis, brain-related genes for coronary artery disease, and liver-related genes for Alzheimer's disease...
October 19, 2018: Nature Communications
Marion Besnard, Damien Babusiaux, Pascal Garaud, Philippe Rosset, Louis Bernard, Louis-Romé Le Nail, Julien Berhouet
INTRODUCTION: Referral Centers for Bone and Joint Infection (BJI) were set up to optimize BJI management thanks to multidisciplinary teamwork. The main aim of the present study was to assess the impact of setting up the Western France Bone and Joint Infection Referral Center on arthroscopic treatment of septic arthritis of the shoulder and knee. The secondary aim was to identify other risk factors for failure of this treatment. The null hypothesis was that there was no difference between the "success group" and the "failure group"...
October 17, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Valentin Ritschl, Angelika Lackner, Carina Boström, Erika Mosor, Michaela Lehner, Maisa Omara, Romualdo Ramos, Paul Studenic, Josef Sebastian Smolen, Tanja Alexandra Stamm
BACKGROUND: It is estimated that 50-70% of patients with rheumatoid arthritis (RA) are non-adherent to their recommended treatment. Non-adherent patients have a higher risk of not reaching an optimal clinical outcome. We explored factors associated with nonadherence from the patient's perspective. METHODS: Four hundred and fifty-nine RA patients (346 (75.4%) females; mean age 63.0 ± 14.8 years) who failed to attend follow-up visits in two rheumatology centres were eligible to participate in a qualitative interview study...
October 19, 2018: Arthritis Research & Therapy
Irazú Contreras-Yáñez, G Guaracha-Basáñez, E Díaz-Borjón, M Iglesias, V Pascual-Ramos
BACKGROUND: Reconstructive joint surgery is an indicator of poor prognosis in rheumatoid arthritis (RA). Objectives of this study were to describe the incidence rate of orthopedic and hand surgery indication (OHSI) in an ongoing cohort of Hispanic early RA patients treated according to a T2T strategy and to investigate predictors. METHODS: Through February 2018, the cohort comprised 185 patients recruited from 2004 onwards, with variable follow-up, and rheumatic assessments at fixed intervals that included prospective determination of OHSI...
October 20, 2018: BMC Musculoskeletal Disorders
Yuying Liu, Jane J Alookaran, J Marc Rhoads
Probiotics have been used to ameliorate gastrointestinal symptoms since ancient times. Over the past 40 years, probiotics have been shown to impact the immune system, both in vivo and in vitro. This interaction is linked to gut microbes, their polysaccharide antigens, and key metabolites produced by these bacteria. At least four metabolic pathways have been implicated in mechanistic studies of probiotics, based on mechanistic studies in animal models. Microbial⁻immune system crosstalk has been linked to: short-chain fatty acid production and signaling, tryptophan metabolism and the activation of aryl hydrocarbon receptors, nucleoside signaling in the gut, and activation of the intestinal histamine-2 receptor...
October 18, 2018: Nutrients
Linnea Bärebring, Anna Winkvist, Inger Gjertsson, Helen M Lindqvist
The aim was to study whether dietary quality was associated with disease activity and inflammation among patients with rheumatoid arthritis (RA). This cross-sectional analysis included 66 Swedish participants, who each completed a food frequency questionnaire (FFQ) at screening. Food intake was scored by a dietary quality index created by the Swedish National Food Agency. Disease activity was measured as Disease Activity Score 28 (DAS28), based on erythrocyte sedimentation rate (ESR), a patient administered visual analogue scale of perceived global health and the number of tender and swollen joints out of 28 examined...
October 18, 2018: Nutrients
Roka Namoto Matsubayashi, Hiromi Iwasaki, Nobutaka Iwakuma, Seiya Momosaki
Tumors originating from the nipple-areolar complex of the breast are rare. We herein report the case of a patient with metachronous bilateral areolar methotrexate (MTX)-associated lymphoma. The patient was a 67-year-old woman who presented with a rapidly enlarging tumor in the areolar region of her left breast. She had a long history of rheumatoid arthritis and had taken MTX for many years. On ultrasonography, the tumor showed well-demarcated margins and hyper-vascularity. On magnetic resonance imaging, the tumor showed a homogeneous low-to-moderate signal intensity that was similar to that of the nipple on both T1- and T2-weighted imaging; the diffusion was significantly reduced on diffusion-weighted images...
October 6, 2018: Clinical Imaging
Manoj Kumar Neog, Mahaboobkhan Rasool
The current study aimed to target the delivery of p-coumaric acid (CA), a dietary polyphenol to the synovial macrophages of AIA rats via mannose incorporated liposomal delivery system (ML) with reference to osteoclastogenesis and bone resorption. In vivo imaging and in vitro drug release study indicated the efficiency of mannosylated liposomes to localize at the site of inflammation and increased sustain drug release respectively. Morphological assessment of isolated synovial macrophages with respect to CD86 (synovial macrophages) and CD51 (pre-/osteoclast) indicated that p-coumaric acid encapsulated mannnosylated liposomes (ML-CA) inhibited the osteoclasts differentiation...
October 16, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Fanxin Zeng, Wei Wen, Weiyi Cui, Wen Zheng, Yuli Liu, Xueting Sun, Ning Hou, Dongwei Ma, Ye Yuan, Huiping Shi, Zhimin Wang, Zezhong Li, Yao Xiao, Can Wang, Yumei Li, Haibao Shang, Chuanyun Li, Jue Wang, Yan Zhang, Rui-Ping Xiao, Xiuqin Zhang
Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by destructive polyarthritis and systemic complications. It increases cardiovascular morbidity and mortality. However, the mechanism underlying RA-related cardiac damage remains largely unknown. Here, we found and characterized a non-human primate (NHP) model with spontaneous RA similar to the human conditions. Compared with the control group, the cardiac function in RA monkeys showed progressively deterioration; histologically, we found significantly increased inflammatory cell infiltration, cell death, and fibrosis in RA monkey heart tissue...
October 16, 2018: Journal of Molecular and Cellular Cardiology
Yvonne Mödinger, Anna E Rapp, Anna Vikman, Zhaozhou Ren, Verena Fischer, Stephanie Bergdolt, Melanie Haffner-Luntzer, Wen-Chao Song, John D Lambris, Markus Huber-Lang, Cornelia Neidlinger-Wilke, Rolf Brenner, Anita Ignatius
The terminal complement complex (TCC) is formed upon activation of the complement system, a crucial arm of innate immunity. TCC formation on cell membranes results in a transmembrane pore leading to cell lysis. In addition, sublytic TCC concentrations can modulate various cellular functions. TCC-induced effects may play a role in the pathomechanisms of inflammatory disorders of the bone, including rheumatoid arthritis and osteoarthritis. In this study we investigated the effect of the TCC on bone turnover and repair...
October 16, 2018: American Journal of Pathology
Christiana Oshotse, Leah L Zullig, Hayden B Bosworth, Pikuei Tu, Cheryl Lin
INTRODUCTION: Rheumatoid arthritis (RA) is a common disease that requires patient self-management with chronic medications. Adherence rates for RA medications are suboptimal. This study explores medication adherence and self-efficacy behaviors among RA patients. METHODS: We conducted a qualitative study comprising focus groups and individual interviews. Nineteen participants were recruited and screened to participate in three 90-minute focus groups (n = 13) and six 60-minute individual interviews...
October 18, 2018: Preventing Chronic Disease
Alexis Ramos, José Domínguez, Soledad Gutiérrez
INTRODUCTION: Rheumatoid arthritis is the most common inflammatory arthritis worldwide. Chronic pain leads patients to use complementary therapies, including acupuncture. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach...
October 10, 2018: Medwave
Ko-Ming Lin, Wei-Ming Chen, Shui-Yi Tung, Kuo-Liang Wei, Chein-Heng Shen, Te-Sheng Chang, Pey-Jium Chang
AIM: In order to increase diagnostic sensitivity for early disease in rheumatoid arthritis (RA), new classification criteria were approved in 2010 by the American College of Rheumatology and the European League Against Rheumatism. One of the criteria, a high-positive rheumatoid factor (RF) or anti-citrullinated protein antibody (ACPA) level, was given a high score of 3. However, the increased prevalence of RF in patients with chronic hepatitis C virus (HCV) infection markedly diminishes the diagnostic specificity of serum RF for RA in these patients...
October 18, 2018: International Journal of Rheumatic Diseases
Toshihisa Kojima, Hajime Ishikawa, Sakae Tanaka, Nobuhiko Haga, Keiichiro Nishida, Masao Yukioka, Jun Hashimoto, Hisaaki Miyahara, Yasuo Niki, Tomoatsu Kimura, Hiromi Oda, Shuji Asai, Koji Funahashi, Masayo Kojima, Naoki Ishiguro
OBJECTIVE: This prospective observational cohort study aimed to set targets for lower limb joint surgery based on the Timed Up and Go test (TUG), an objective functional outcome measure, in patients with established rheumatoid arthritis (RA). METHODS: We validated TUG as an outcome measure of lower limb joint surgery and compared it with changes in patient-reported outcomes, including the Health Assessment Questionnaire Disability Index (HAQ-DI) and European Quality of life scale with five dimensions (EQ-5D)...
October 18, 2018: International Journal of Rheumatic Diseases
Toshiyuki Watanabe, Jun Fukae, Shinji Fukaya, Norifumi Sawamukai, Masato Isobe, Megumi Matsuhashi, Masato Shimizu, Kazumasa Akikawa, Kazuhide Tanimura, Tatsuya Atsumi, Takao Koike
AIM: To identify the incidence and risk factors for hepatitis B virus (HBV) reactivation in rheumatoid arthritis (RA) patients with resolved HBV receiving biological disease-modifying antirheumatic drugs (bDMARDs). METHOD: Rheumatoid arthritis patients in whom bDMARD therapy was initiated in our departments from April 2009 to July 2016 were reviewed. The patients diagnosed with resolved HBV and whose HBV-DNA levels had been repeatedly measured were enrolled. The endpoint was HBV reactivation (a positive conversion of HBV-DNA or unquantifiable cases with positivity <20 IU/mL)...
October 18, 2018: International Journal of Rheumatic Diseases
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