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"Rheumatoid Arthritis"

Adam Bennett, Jayasree Ramaskandhan, Malik Siddique
BACKGROUND: Outcomes for total ankle replacement (TAR) performed for osteoarthritis following pilon fracture are underreported. We compared the outcomes between different indications for TAR. METHODS: Patient-reported outcome measures (PROMs) for TAR performed from 2006 to 2014 by a single surgeon were reviewed. Foot and Ankle Outcome Score (FAOS), SF-36, comorbidities, self-reported body mass index (BMI), and patient satisfaction scores were reviewed. Data were collected preoperatively and at 1 and 2 years postoperatively...
August 15, 2018: Foot & Ankle International
Jeffrey A Sparks, Medha Barbhaiya, Sara K Tedeschi, Cianna L Leatherwood, Fred K Tabung, Cameron B Speyer, Susan Malspeis, Karen H Costenbader, Elizabeth W Karlson, Bing Lu
Our objective was to investigate whether a dietary pattern derived using inflammatory biomarkers is associated with rheumatoid arthritis (RA) risk. We prospectively followed 79,988 women in the Nurses' Health Study (NHS, 1984-2014) and 93,572 women in the NHSII (1991-2013); incident RA was confirmed by medical records. Food frequency questionnaires (FFQ) were completed at baseline and approximately every 4 years. Inflammatory dietary pattern was assessed from FFQ data using the Empirical Dietary Inflammatory Pattern (EDIP), including 18 anti-/pro-inflammatory food/beverage groups weighted by correlations with plasma inflammatory biomarkers (interleukin-6, C-reactive protein, and tumor necrosis factor-α receptor 2)...
August 14, 2018: Clinical Rheumatology
Yi-Ju Pan, Wei-Hsun Wang, Tzu-Yao Huang, Wei-Hsiang Weng, Chun-Kai Fang, Yu-Chan Chen, Jeng-Jong Hwang
OBJECTIVE AND DESIGN: To investigate the amelioration effects of quetiapine on rheumatoid arthritis with RAW 264.7 macrophage and collagen-induced arthritis (CIA) DBA/1J mouse model. SUBJECTS: RAW 264.7 macrophage and DBA/1J mice. TREATMENT: Lipopolysaccharide and collagen. METHODS: RAW 264.7 macrophages stimulated by lipopolysaccharide (LPS) followed by quetiapine treatments were investigated. Activations of CD80 and CD86 were analyzed by flow cytometry...
August 14, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
Heng Yin, Haijing Wu, Yongjian Chen, Jianzhong Zhang, Min Zheng, Genhui Chen, Linfeng Li, Qianjin Lu
Autophagy is a complicated cellular mechanism that maintains cellular and tissue homeostasis and integrity via degradation of senescent, defective subcellular organelles, infectious agents, and misfolded proteins. Accumulating evidence has shown that autophagy is involved in numerous immune processes, such as removal of intracellular bacteria, cytokine production, autoantigen presentation, and survival of lymphocytes, indicating an apparent and important role in innate and adaptive immune responses. Indeed, in genome-wide association studies, autophagy-related gene polymorphisms have been suggested to be associated with the pathogenesis of several autoimmune and inflammatory disorders, such as systemic lupus erythematosus, psoriasis, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis...
2018: Frontiers in Immunology
Meng Chen, Zhenbin Li, Zheng Zhang, Yong Du, Yingjie Zhang, Minghua Xu, Caixia Sun
Rheumatoid arthritis (RA) is a systemic autoimmune disease that can destroy peripheral joints. However, very little is known regarding specific biological marker for RA in Chinese patients. In this study, we determined the serum biomarkers and clinical features of RA-CVD. We also evaluated the short-term efficacy of routine RA treatment combined with integrative medicine treatment on RA-CVD. We found that anti-cyclic citrullinated peptide (CCP) and disease activity score in 28 joints (DAS28) are associated with risks of cardiovascular disease (CVD) in RA...
July 2018: Saudi Journal of Biological Sciences
Nida Saleem, Tahir Aziz Ahmed, Mukarram Bashir, Muhammad Omair Riaz, Ali Hamid
OBJECTIVE: To compare the frequency and the functional state of the collagen II reactive T cells with disease activity in rheumatoid arthritis patients and healthy controls. METHODS: This case-control cross-sectional study was carried out at the Department of Immunology; Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from June to October 2014. Rheumatologist from Rehmat Noor Rheumatology Clinic, a private health facility of the city, was requested to send in patients with clinical diagnosis of rheumatoid arthritis...
August 2018: JPMA. the Journal of the Pakistan Medical Association
Parker F Duffney, Megan L Falsetta, Ashley R Rackow, Thomas H Thatcher, Richard P Phipps, Patricia J Sime
Chronic inflammation is an underlying feature of many diseases, including chronic obstructive pulmonary disease, rheumatoid arthritis, asthma, and multiple sclerosis. There is an increasing appreciation of the dysregulation of adaptive immunity in chronic inflammatory and allergic diseases. The discovery of specialized pro-resolving lipid mediators (SPMs) that actively promote the resolution of inflammation has opened new avenues for the treatment of chronic inflammatory diseases. Much work has been done focusing on the impact of SPMs on innate immune cells...
July 2, 2018: Journal of Clinical Investigation
Muhammad Ali Fazal, Jason Hol-Ming Wong, Luthfur Rahman
OBJECTIVE: First MTP joint fusion is a reliable procedure for advanced arthritis for the first MTP joint. There are many techniques described. The purpose of our study is to report clinical, radiological, functional outcomes and complications of first metatarsophalangeal joint fusion with hand preparation of the joint and fixation with two orthogonal locking plates without a compression screw. METHODS: 32 feet in 26 consecutive patients under went first metatarsophalangeal joint fusion with above technique...
August 11, 2018: Acta Orthopaedica et Traumatologica Turcica
Sindhu G, Shyni G L, Chithra K Pushpan, Bala Nambisan, Helen A
Rheumatoid arthritis is a chronic inflammatory joint disease characterized by synovial proliferation and tissue destruction. Pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) play a key role in the disease process and elevate energy expenditure, which further increases the joint pain and stiffness. The present study was undertaken to explore the anti-arthritic potential of fenugreek mucilage in adjuvant induced arthritic rats. In the present study, paw volume was measured on the 7th , 14th and 21st day...
August 11, 2018: Prostaglandins & Other Lipid Mediators
Lijun Song, Yunqing Wang, Yameng Sui, Jiao Sun, Dong Li, Guosheng Li, Jianwei Liu, Tianwang Li, Qiang Shu
BACKGROUND Anti-inflammatory mediators such as mucin-domain containing-3 (TIM-3) and IL-37 play an important role in the regulation of Th1-mediated immunity. This study was designed to investigate the proportions of various T cell subsets and monocytes in the peripheral blood of rheumatoid arthritis (RA) patients, as well as the level of TIM-3 on these cells and serum cytokine levels. MATERIAL AND METHODS We enrolled 59 RA patients and 46 age- and sex-matched healthy controls in this study. The proportion of T cells and TIM-3 expression on these T cells were determined by flow cytometry...
August 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Stefanie D Wade, Eric M Yoshida, Mollie N Carruthers, Michael E Weinblatt
No abstract text is available yet for this article.
August 13, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Seii Ohka, Daisuke Nishizawa, Junko Hasegawa, Kaori Takahashi, Kyoko Nakayama, Yuko Ebata, Ken-Ichi Fukuda, Kazutaka Ikeda
AIM: Interleukin-17A (IL-17A) plays an essential role in tissue inflammation by inducing proinflammatory cytokine and chemokine production and is related to innate immune reactions. IL-17A also contributes to neuroinflammation, neuropathic pain, and mechanical hypersensitivity after peripheral nerve injury in rodents. To clarify the contribution of IL-17A to pain-related phenotypes in humans, we investigated the association between pain-related phenotypes and the rs2275913 single-nucleotide polymorphism (SNP) of the IL-17A gene, which has been reported to be associated with rheumatoid arthritis, ulcerative colitis, and some cancers...
June 2018: Neuropsychopharmacology reports
Eirini Vasarmidi, Stella Sarantoulaki, Athina Trachalaki, George Margaritopoulos, Eleni Bibaki, Demetrios A Spandidos, Nikolaos Tzanakis, Katerina Antoniou
Idiopathic pulmonary fibrosis (IPF) is a chronic and irreversible interstitial lung disease with a poor prognosis and limited therapeutic options. Over the past decade, research efforts have focused on the pathogenetic mechanisms involved in this enigmatic lung disease. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease often complicated by the development of interstitial lung disease (ILD), leading to high mortality and morbidity. Autophagy is a process regulating the turnover of subcellular components and organelles, and represents a major cellular homeostatic mechanism...
August 6, 2018: Molecular Medicine Reports
Xin Wang, Xueping Wang, Jin Sun, Shiou Fu
Rheumatoid arthritis (RA) is considered to be a systemic autoimmune disease that induces systemic complications and progressive disability. It affects a large number of people. RA fibroblast‑like synoviocytes (RA‑FLS) promote the progression of RA through the secretion of proinflammatory cytokines and increasing invasiveness into the extracellular matrix. Therefore, targeting RA‑FLS represents a potential approach for the treatment of RA. Ribonucleotide reductase M2 (RRM2), a critical protein for DNA synthesis and repair, may promote the proliferation of cells and inhibit cellular apoptosis...
August 8, 2018: International Journal of Molecular Medicine
Dongsheng Fan, Ting Li, Zhiyuan Zheng, Guo-Yuan Zhu, Xiaojun Yao, Zhi-Hong Jiang, Li-Ping Bai
Nine new monomacrolide sesquiterpene pyridine alkaloids, macroregelines A-I (1-9), were isolated from the stems of Tripterygium regelii, along with a known alkaloid, tripfordine B. The structures of all the isolated compounds were characterized by extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopic analyses, as well as high-resolution electrospray-ionization mass spectrometry (HRESIMS) data. Compounds 4, 5, 6, and 8 showed antiproliferative effect on human rheumatoid arthritis synovial cell line MH7A at concentration of 20 μM, reducing their viability by 7...
August 13, 2018: Journal of Natural Medicines
Pauline Raaschou, Jonas Söderling, Carl Turesson, Johan Askling
Background: Use of tumor necrosis factor inhibitors (TNFi) in patients with a history of cancer remains a clinical dilemma. Objective: To investigate whether TNFi treatment in rheumatoid arthritis (RA) is associated with increased risk for cancer recurrence. Design: Population-based cohort study based on linkage of nationwide registers. Setting: Sweden. Participants: Patients with RA who started TNFi treatment between 2001 and 2015, after being diagnosed with cancer, and matched patients with RA and a history of the same cancer who had never received biologics...
August 14, 2018: Annals of Internal Medicine
Jian-Ying Wang, Xiao-Jun Chen, Lei Zhang, Ying-Yi Pan, Zu-Xi Gu, Shi-Min He, Zhe-Ping Song, Ying Yuan
To compare efficacy of different extracts from Eucommia ulmoides Oliv. with both immune inflammation and joint destruction in collagen induced arthritis (CIA) rat model. Rats were divided into normal group (Nor), control group (CIA), TG group (treated with tripterygium glycoside), E70 group (treated with 70% ethanol extract from Eucommia ulmoides Oliv.), EA group (treated with ethyl acetate fraction from E70), and EN group (treated with n-butyl alcohol fraction from E70). All extracts from Eucommia ulmoides Oliv...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Kerstin Göbel, Susann Eichler, Heinz Wiendl, Triantafyllos Chavakis, Christoph Kleinschnitz, Sven G Meuth
Background: The interaction of coagulation factors has been shown to go beyond their traditional roles in hemostasis and to affect the development of inflammatory diseases. Key molecular players, such as fibrinogen, thrombin, or factor XII have been mechanistically and epidemiologically linked to inflammatory disorders like multiple sclerosis (MS), rheumatoid arthritis (RA), and colitis. Objectives: To systematically review the evidence for a role of coagulation factors, especially factor XII, fibrinogen, and thrombin in inflammatory disorders like MS, RA, and bowel disorders...
2018: Frontiers in Immunology
Christoph Biehl, Thomas Braun, Ulrich Thormann, Amir Oda, Gabor Szalay, Stefan Rehart
BACKGROUND: The aim of this retrospective study is to evaluate distal resection interposition arthroplasty of the wrist as a tool to restore mobility as well as to restore stability in severely destroyed wrist joints. METHODS: Thirty-four wrists in 28 rheumatoid arthritis patients were included. The mean follow-up time was 9 years after surgical treatment with clinical and radiological examination. The results were accessed based on a modification of Clayton ́s scoring system as well as a functional questionnaire...
August 14, 2018: BMC Musculoskeletal Disorders
Konstantia Psianou, Ioannis Panagoulias, Anastasios D Papanastasiou, Anne-Lise de Lastic, Maria Rodi, Panagiota I Spantidea, Søren E Degn, Panagiotis Georgiou, Athanasia Mouzaki
Sjögren's syndrome (SS) is a chronic autoimmune disease that primarily affects the exocrine glands, resulting in their functional impairment. In SS, lymphocytic infiltration of salivary and lacrimal glands, and deposition of several types of autoantibodies, mainly anti-SS-A (anti-Ro) and anti-SS-B (anti-La), lead to chronic inflammation, with xerostomia and keratoconjunctivitis sicca. In its primary form (pSS), SS does not involve additional connective tissue diseases, whereas in its secondary and more common form (sSS), SS presents in association with other rheumatic autoimmune diseases, mainly rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc)...
August 10, 2018: Autoimmunity Reviews
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