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Psoriatic AND arthritis

Gustavo Deza, Jaime Notario, Anna Lopez-Ferrer, Eva Vilarrasa, Marta Ferran, Elena Del Alcazar, José-Manuel Carrascosa, Marina Corral, Montserrat Salleras, Miquel Ribera, Lluís Puig, Ramon M Pujol, David Vidal, Fernando Gallardo
BACKGROUND: Ixekizumab (anti-IL17A) is effective as treatment for moderate to severe plaque psoriasis, but real-life data on effectiveness and safety are currently very limited. OBJECTIVE: To evaluate the efficacy and safety of ixekizumab in a cohort of real-life plaque psoriasis patients. METHODS: Retrospective chart review of 100 patients with moderate to severe plaque psoriasis treated with ixekizumab at 7 Spanish dermatological centers...
October 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Y Okubo, T Mabuchi, K Iwatsuki, H Elmaraghy, H Torisu-Itakura, Y Morisaki, K Nakajo
BACKGROUND: Erythrodermic and generalized pustular psoriasis are rare, difficult to treat forms of psoriasis. In previous reports, we documented 24- and 52-week findings of an open-label, phase 3 trial (UNCOVER-J) of ixekizumab in Japanese patients with erythrodermic or generalized pustular psoriasis; most patients responded to treatment and maintained response through 52 weeks. OBJECTIVE: To assess the long-term (>3 years) efficacy and safety of ixekizumab in Japanese patients with erythrodermic or generalized pustular psoriasis...
October 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Stephen Chu-Sung Hu, Chi-Ling Lin, Hung-Pin Tu
BACKGROUND: Psoriasis is a common skin disease that has been recently found to be associated with various systemic inflammatory disorders. However, the association between psoriasis and gout has not been well defined. OBJECTIVE: We investigated whether there is an association between psoriasis, psoriatic arthritis and gout in a large population of patients in Taiwan. METHODS: A nationwide population-based cross-sectional study was performed using the Taiwanese National Health Insurance Research Database (NHIRD)...
October 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Adam Berlinberg, Jawad Bilal, Irbaz B Riaz, Drew J B Kurtzman
BACKGROUND: Citation analysis is a quantitative, bibliometric method that analyzes the frequency and pattern of citations in any given scientific discipline. Over the last two decades, the study of psoriatic arthritis has undergone substantial progress, which has enhanced our ability to assess and treat the disease, and yet an updated citation analysis that reflects these advances is lacking. OBJECTIVE: To highlight the scientific progress in psoriatic arthritis by identifying and analyzing the 100 top-cited psoriatic arthritis articles from the last 40 years...
October 12, 2018: International Journal of Dermatology
J A Walsh, A B Gottlieb, B Hoepken, T Nurminen, P J Mease
The above article originally published with an error present in Discussion section and presented correctly in this article. The original article was corrected.
October 11, 2018: Clinical Rheumatology
Lloyd J Ridley, Jason Han, William E Ridley, Hao Xiang
No abstract text is available yet for this article.
October 2018: Journal of Medical Imaging and Radiation Oncology
Luca Navarini, Domenico Paolo Emanuele Margiotta, Francesco Caso, Damiano Currado, Marco Tasso, Silvia Angeletti, Massimo Ciccozzi, Raffaele Scarpa, Antonella Afeltra, Luisa Costa
INTRODUCTION: In patients with psoriatic arthritis (PsA) an increased cardiovascular (CV) risk has been observed. Recently, a EULAR taskforce suggested to use a multiplication by the factor of 1.5 of CV risk algorithms in patients with inflammatory arthritis. This study aims to evaluate the performance of five original and adapted according to EULAR recommendations CV risk algorithms in PsA: SCORE, CUORE, Framingham Risk Score (FRS), QRISK2, and Reynold's Risk Score (RRS). METHODS: Prospectively collected data from two Italian cohorts were used...
2018: PloS One
Carolina Zorzanelli Costa, Claudia Goldenstein-Schainberg, Sueli Carneiro, José Joaquim Rodrigues, Ricardo Romiti, Thiago Bitar Martins Barros, Gladys Martins, Jamile Carneiro, Rachel Grynszpan, Ana Luisa Sampaio, Tânia Maria Silva Mendonça, Carlos Henrique Martins Silva, Abrar A Qureshi, Rogerio de Melo Costa Pinto, Roberto Ranza
PASE (Psoriatic Arthritis Screening and Evaluation) was developed in the English language to screen for inflammatory arthritis among patients with psoriasis. It is 15 item self administered questionnaire with a score from 15 to 75. A higher score indicates a greater risk for inflammatory joint disease. The purpose of this study was to translate, adapt and validate this questionnaire into Brazilian Portuguese (PASE-P). METHODS: 465 patients diagnosed with psoriasis (158 with psoriatic arthritis confirmed by a rheumatologist according to the CASPAR criteria and 307 without) were evaluated in dermatology clinics...
2018: PloS One
Eirik Ikdahl, Silvia Rollefstad, Grunde Wibetoe, Anne Salberg, Frode Krøll, Kjetil Bergsmark, Tore K Kvien, Inge C Olsen, Dag Magnar Soldal, Gunnstein Bakland, Åse Lexberg, Clara G Gjesdal, Christian Gulseth, Glenn Haugeberg, Anne Grete Semb
Objective: The European League Against Rheumatism recommends implementing cardiovascular disease (CVD) risk assessments for patients with inflammatory joint diseases (IJDs) into clinical practice. Our goal was to design a structured programme for CVD risk assessments to be implemented into routine rheumatology outpatient clinic visits. Methods: The NOrwegian Collaboration on Atherosclerosis in patients with Rheumatic joint diseases (NOCAR) started in April 2014 as a quality assurance project including 11 Norwegian rheumatology clinics...
2018: RMD Open
Alejandro Molina-Leyva, Luis Salvador-Rodriguez, Antonio Martinez-Lopez, Jose Carlos Ruiz-Carrascosa, Salvador Arias-Santiago
Importance: Sexual health is a major aspect of life. Increasing scientific evidence shows a potential association between psoriasis and sexual dysfunction (SD) and erectile dysfunction (ED). Objective: To evaluate the available scientific evidence regarding epidemiologic associations and treatment outcomes between psoriasis and SD and ED. Evidence Review: Information sources were MEDLINE and Embase databases, using the Scopus search engine...
October 10, 2018: JAMA Dermatology
James T Rosenbaum, Mark Asquith
Acute anterior uveitis (AAU) and the spondyloarthritis (SpA) subtypes ankylosing spondylitis, reactive arthritis and psoriatic arthritis are among the inflammatory diseases affected by the biology of the intestinal microbiome. In this Review, the relationship between AAU, SpA and the microbiome is discussed, with a focus on the major SpA risk gene HLA-B*27 and how it is associated with both intestinal tolerance and the loss of ocular immune privilege that can accompany AAU. We provide four potential mechanisms to account for how dysbiosis, barrier function and immune response contribute to the development of ocular inflammation and the pathogenesis of AAU...
October 9, 2018: Nature Reviews. Rheumatology
Matthew T Patrick, Philip E Stuart, Kalpana Raja, Johann E Gudjonsson, Trilokraj Tejasvi, Jingjing Yang, Vinod Chandran, Sayantan Das, Kristina Callis-Duffin, Eva Ellinghaus, Charlotta Enerbäck, Tõnu Esko, Andre Franke, Hyun M Kang, Gerald G Krueger, Henry W Lim, Proton Rahman, Cheryl F Rosen, Stephan Weidinger, Michael Weichenthal, Xiaoquan Wen, John J Voorhees, Gonçalo R Abecasis, Dafna D Gladman, Rajan P Nair, James T Elder, Lam C Tsoi
Psoriatic arthritis (PsA) is a complex chronic musculoskeletal condition that occurs in ~30% of psoriasis patients. Currently, no systematic strategy is available that utilizes the differences in genetic architecture between PsA and cutaneous-only psoriasis (PsC) to assess PsA risk before symptoms appear. Here, we introduce a computational pipeline for predicting PsA among psoriasis patients using data from six cohorts with >7000 genotyped PsA and PsC patients. We identify 9 new loci for psoriasis or its subtypes and achieve 0...
October 9, 2018: Nature Communications
Ewa Ambrożewicz, Piotr Wójcik, Adam Wroński, Wojciech Łuczaj, Anna Jastrząb, Neven Žarković, Elżbieta Skrzydlewska
Inflammatory granulocytes are characterized by an oxidative burst, which may promote oxidative stress and lipid modification both in affected tissues and on a systemic level. On the other hand, redox signaling involving lipid peroxidation products acting as second messengers of free radicals play important yet not fully understood roles in the pathophysiology of inflammation and various stress-associated disorders. Therefore, the aim of this study was to evaluate the onset of oxidative stress and alterations of enzyme-dependent lipid metabolism resulting from redox imbalance in granulocytes and plasma obtained from patients with psoriasis vulgaris or psoriatic arthritis in comparison to the healthy subjects...
October 6, 2018: Cells
Yuqian Feng, Miao Yu, Feng Zhu, Shaoshao Zhang, Peiwu Ding, Min Wang
The development of deep venous thrombosis (DVT) is a sterile inflammatory process related to cytokines, such as interleukin (IL)-6 or IL-17. IL-9 is a cytokine involved in many inflammatory diseases, including cystic fibrosis, ulcerative colitis, psoriasis and psoriatic arthritis. However, it remains unknown whether IL-9 is related to DVT. In this study, we characterized the role and mechanism of IL-9 in DVT. Analysis of the data of patients with and without DVT revealed that stasis, venous surgery as well as elevated IL-9 and sP-selectin levels were related to the development of DVT...
October 9, 2018: Thrombosis and Haemostasis
Erwin Dreesen, Ann Gils
BACKGROUND: Psoriasis, psoriatic arthritis, spondyloarthritis, rheumatoid arthritis, ulcerative colitis and Crohn's disease share similar underlying pathophysiological processes, providing the opportunity to treat the patients using similar biological therapies. Failure of biological treatments due to underexposure can be managed by therapeutic drug monitoring. Adjusting the treatment based on pharmacokinetic monitoring can be further improved by taking pharmacodynamic parameters such as clinical and molecular markers into account...
October 3, 2018: Therapeutic Drug Monitoring
Garifallia Sakellariou, Giovanni Lombardi, Barbara Vitolo, Marta Gomarasca, Martina Faraldi, Roberto Caporali, Giuseppe Banfi, Carlomaurizio Montecucco
OBJECTIVES: We aimed to evaluate the correlation between serum calprotectin and clinical and ultrasonographic (US) variables in early-onset psoriatic arthritis (PsA) and controls with rheumatoid arthritis (RA). METHODS: In a retrospective cross-sectional study, including PsA and matched RA patients, 44 joint counts (TJC, SJC), calprotectin, ESR and CRP were measured. US of wrists and MCPs 1-5 was performed, with grey-scale (GS) and power Doppler (PD) scored 0-3 at each site, summed in a total score...
October 8, 2018: Clinical and Experimental Rheumatology
Michael P Migkos, Georgios-Petros Somarakis, Theodora E Markatseli, Paraskevi V Voulgari, Alexandros A Drosos
Psoriatic arthritis (PsA) is a specific form of inflammatory arthritis associated with skin psoriasis. PsA makes part of a heterogeneous group of arthritides called the spondyloarthropathies. Several studies regarding the prevalence and incidence of PsA have been published during the last decades, showing a considerable variation of the disease occurrence among different populations. The purpose of this review is to discuss recent observations of epidemiological features for PsA patients. Thus, the literature was reviewed until May 2018 for studies regarding PsA epidemiology, classification criteria and risk factors for PsA development...
October 8, 2018: Clinical and Experimental Rheumatology
Sara K Felbo, Lene Terslev, Mikkel Østergaard
Imaging in psoriatic arthritis (PsA) is rapidly evolving, and the use of sensitive modalities both in clinical research and routine care is increasing. This article provides an overview of current knowledge of different imaging methods in PsA, including current and possible future use in diagnosis, prognosis and clinical management, value in understanding pathogenesis, and latest activities to establish responsive imaging outcome measures. Much research remains to be performed concerning imaging in PsA, particularly on its optimal use in routine clinical care, the clinical consequences of imaging-detected subclinical disease, and specific and sensitive PsA imaging outcome measures...
September 2018: Clinical and Experimental Rheumatology
Maria-Antonietta D'Agostino
Over the last 25 years, ultrasound has been used to evaluate involvement at the entheses in spondyloarthritis (SpA) and psoriatic arthritis (PsA). Several studies have been reported indicating its value in detecting active inflammation at entheseal sites using both gray scale and Doppler findings. This review explores the recent literature and appraises the current knowledge and the unmet needs of enthesitis detection by ultrasound in the management of both SpA and PsA.
September 2018: Clinical and Experimental Rheumatology
Ellis Niemantsverdriet, Annette H M van der Helm-van Mil
Tenosynovitis is traditionally recognised at physical examination in patients with inflammatory rheumatic diseases, such as, e.g. psoriatic arthritis and (longstanding) rheumatoid arthritis (RA). The increasing use of sensitive imaging techniques (ultrasound, magnetic resonance imaging (MRI)) has recently revealed that subclinical tenosynovitis is prevalent in early RA and in patients in different phases of RA development (asymptomatic state, arthralgia, early arthritis). In this review, the recent findings on MRI-detected tenosynovitis and associations with RA development are highlighted, and an overview of the most reported inflamed tendon locations within the hand and wrist of patients in different disease phases is provided...
September 2018: Clinical and Experimental Rheumatology
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