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Psoriatic AND arthritis

Luis R Espinoza
PURPOSE OF REVIEW: Psoriatic arthritis is a distinct disorder, separate from rheumatoid arthritis, and first recognized in a thirteenth century Saxon skeleton. It was, however, the monumental work of Verna Wright in the 1950s that led to the acceptance by the American Rheumatism Association (now American College of Rheumatology) in 1964 as a distinct entity. Wright's work provided the framework for a better understanding of the pathogenic mechanisms operating on this condition, and eventually led to the development of targeted therapy that has proven to be more effective and safe than conventional therapy...
August 9, 2018: Current Rheumatology Reports
Elsa Vieira-Sousa, Helena Canhão, Pedro Alves, Ana Maria Rodrigues, Filipa Teixeira, José Tavares-Costa, Alexandra Bernardo, Sofia Pimenta, Fernando Pimentel-Santos, João L Gomes, Renata Aguiar, Taciana Videira, Patrícia Pinto, Cristina Catita, Helena Santos, Joana Borges, Graça Sequeira, Célia Ribeiro, Lídia Teixeira, Pedro Ávila-Ribeiro, Fernando M Martins, Ruy M Ribeiro, João Eurico Fonseca
The GO-DACT is an investigator-initiated, national, multicentric randomized placebo-controlled double-blinded trial, that assesses dactylitis as primary endpoint. Psoriatic arthritis patients naïve to methotrexate and biologic disease modifying anti-rheumatic drugs, with at least one active dactylitis, were assigned to golimumab in combination with methotrexate or placebo in combination with methotrexate, for 24 weeks. Both clinical (dactylitis severity score and the Leeds dactylitis index) and imaging (high resolution magnetic resonance imaging), among others, were assessed as outcomes...
April 2018: Acta Reumatológica Portuguesa
Joshua L Lee, Premarani Sinnathurai, Rachelle Buchbinder, Catherine Hill, Marissa Lassere, Lyn March
BACKGROUND: Inflammatory arthritides including rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) are associated with increased risk of cardiovascular disease. This process may be driven by systemic inflammation, and the use of tumour necrosis factor (TNF) inhibitors could therefore potentially reduce cardiovascular risk by reducing this inflammatory burden. The aims of this study were to evaluate whether the risk of cardiovascular events (CVEs) in patients with inflammatory arthritis is associated with treatment with anti-TNF therapy, compared with other biologics or non-biologic therapy, and to compare the CVE risk between participants with RA, PsA and AS...
August 7, 2018: Arthritis Research & Therapy
Kjersti Danielsen, Albert Duvetorp, Lars Iversen, Mikkel Østergaard, Oliver Seifert, Kåre Steinar Tveit, Lone Skov
Optimal clinical management of psoriasis and psoriatic arthritis (PsA) requires understanding of the impact on patients. The NORdic PAtient survey of Psoriasis and PsA (NORPAPP) aimed to obtain current data on disease prevalence and patient perceptions in Sweden, Denmark and Norway. Among 22,050 individuals questioned, the reported prevalence of psoriasis and/or PsA was 9.7% (5.7% physician-diagnosed plus 4.0% self-diagnosed only); prevalence was similar in Sweden (9.4%) and Denmark (9.2%) but significantly higher in Norway (11...
August 7, 2018: Acta Dermato-venereologica
F Iannone, F Salaffi, M Fornaro, M Di Carlo, S Gentileschi, L Cantarini, G Lopalco
AIM: To assess the impact of baseline modified Rheumatic Disease Comorbidity Index (mRDCI) a simple co-morbidity count, on overall survival of treatments with biological drugs in patients affected with Rheumatoid Arthritis (RA), Spondyloarthritis (SpA), and Psoriatic Arthritis (PsA) in real-world settings. METHODS: Patients (nr. 635) with RA (nr. 214), SpA (nr. 213), and PsA (nr. 208) starting a first biological drug were retrospectively analysed. mRDCI was scored at baseline, and disease characteristics were recorded at entry and at last observation...
August 5, 2018: European Journal of Clinical Investigation
Kristy S Yap, Justine Y Ye, Suzanne Li, Dafna D Gladman, Vinod Chandran
OBJECTIVE: We aimed to determine the agreement between rheumatologist-judged inflammatory back pain (IBP) and criteria defining IBP in patients with psoriatic arthritis (PsA) and predictive value of IBP in identifying axial involvement in PsA. METHODS: Using prospectively collected data, we investigated the agreement between rheumatologist judgement of IBP and IBP criteria (Calin, Rudwaleit and Assessment of Spondyloarthritis International Society) using the kappa coefficient...
August 4, 2018: Annals of the Rheumatic Diseases
Peter V Balint, Lene Terslev, Philippe Aegerter, George Arthur Willem Bruyn, Isabelle Chary-Valckenaere, Frederique Gandjbakhch, Annamaria Iagnocco, Sandrine Jousse-Joulin, Ingrid Möller, Esperanza Naredo, Wolfgang A Schmidt, Richard J Wakefield, Maria-Antonietta D'Agostino
OBJECTIVES: To evaluate the reliability of consensus-based ultrasound (US) definitions of elementary components of enthesitis in spondyloarthritis (SpA) and psoriatic arthritis (PsA) and to evaluate which of them had the highest contribution to defining and scoring enthesitis. METHODS: Eleven sonographers evaluated 40 entheses from five patients with SpA/PsA at four bilateral sites. Nine US elementary lesions were binary-scored: hypoechogenicity, thickened insertion, enthesophytes, calcifications, erosions, bone irregularities, bursitis and Doppler signal inside and around enthesis...
August 3, 2018: Annals of the Rheumatic Diseases
Glenn Haugeberg, Brigitte Michelsen, Stig Tengesdal, Inger Johanne Widding Hansen, Andreas Diamantopoulos, Arthur Kavanaugh
BACKGROUND: Over the last decade, a treat-to-target (T2T) strategy has been recommended for psoriatic arthritis (PsA) and new treatment options have become available. There is a lack of data on PsA regarding any changes that may have occurred over these past years. Thus, the main aim of this study was to look for changes in clinical disease status and treatment in a PsA outpatient clinic population monitored over the period 2008 to 2017. METHODS: Annual data collection included demographic data, laboratory (erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)) and clinic measures of disease activity (e...
August 2, 2018: Arthritis Research & Therapy
Francesca Pica, Roberta Gaziano, Ida Antonia Casalinuovo, Gabriella Moroni, Cristina Buè, Dolores Limongi, Cartesio D'Agostini, Carlo Tomino, Roberto Perricone, Anna Teresa Palamara, Paola Sinibaldi Vallebona, Enrico Garaci
Thymosin alpha 1 (Ta1) is a natural occurring peptide hormone that is crucial for the maintenance of the organism homeostasis. It has been chemically synthesized and used in diseases where the immune system is hindered or malfunctioning. Areas covered: Many clinical trials investigate the Ta1 effects in patients with cancer, infectious diseases and as a vaccine enhancer. The number of diseases that could benefit from Ta1 treatment is increasing. To date, questions remain about the physiological basal levels of Ta1 and the most effective dose and schedule of treatment...
July 2018: Expert Opinion on Biological Therapy
Marzia Dolcino, Andrea Pelosi, Piera Filomena Fiore, Giuseppe Patuzzo, Elisa Tinazzi, Claudio Lunardi, Antonio Puccetti
Psoriatic arthritis (PsA) is an inflammatory arthritis, characterized by inflammation of entheses and synovium, leading to joint erosions and new bone formation. It affects 10-30% of patients with psoriasis, and has an estimated prevalence of approximately 1%. PsA is considered to be primarily an autoimmune disease, driven by autoreactive T cells directed against autoantigens present in the skin and in the joints. However, an autoinflammatory origin has recently been proposed. Long noncoding RNAs (lncRNAs) are RNAs more than 200 nucleotides in length that do not encode proteins...
2018: Frontiers in Immunology
Alen Zabotti, Peter Mandl, Giuseppe Zampogna, Christian Dejaco, Annamaria Iagnocco
Ultrasound is playing an increasingly important role in the differential diagnosis and monitoring of rheumatoid arthritis (RA) and psoriatic arthritis (PsA). This technique is more sensitive and specific than clinical examination to detect active synovitis, and the identification of specific synovitis patterns enable differentiation of PsA from RA and other entities. Ultrasound verified inflammation changes along with clinical improvement during therapy, and ultrasound was shown to predict future clinical and structural outcomes thus complementing the clinical risk assessment of patients...
July 2018: Clinical and Experimental Rheumatology
Patrycja Ozdowska, Łukasz Wardziak, Mariusz Kruk, Cezary Kępka, Ilona Kowalik, Hanna Szwed, Piotr Głuszko, Robert Rupiński, Brygida Kwiatkowska, Katarzyna Sikorska-Siudek, Rafał Dąbrowski
Introduction There is substantial evidence that spondyloarthropathies such as ankylosing spondylitis (AS) and psoriatic arthritis may increase cardiovascular risk. Objectives The study aimed to compare development of atherosclerotic lesions in coronary arteries in patients with AS and in the control group (CG). Patients and methods A total of 37 adult patients with AS (mean [SD] age, 40.4 [9.6] years;  26, 70.3% men), with disease duration <10 years were enrolled. The CG consisted of 76 subjects without rheumatological diseases...
July 27, 2018: Polish Archives of Internal Medicine
WanLi Zhou, Vinod Chandran, Richard Cook, Dafna D Gladman, Lihi Eder
OBJECTIVE: To assess the association between occupational-related mechanical factors and the severity of radiographic peripheral and axial joint damage in patients with longstanding Psoriatic Arthritis (PsA). METHODS: Patients with longstanding PsA (disease duration≥10 years) were identified from a prospective longitudinal cohort. Using an occupation history questionnaire, patients were asked to report all paid employments since the age of 18. The key predictor variables included various occupational-related mechanical exposures...
June 19, 2018: Seminars in Arthritis and Rheumatism
Michele Maria Luchetti, Devis Benfaremo, Anna Campanati, Elisa Molinelli, Monia Ciferri, Serena Cataldi, William Capeci, Marco Di Carlo, Anna Maria Offidani, Fausto Salaffi, Armando Gabrielli
Psoriatic arthritis (PsA) is a chronic inflammatory autoimmune arthritis, occurring in patients with psoriasis (Pso), that may affect the whole musculoskeletal system but also nails, eye, and gastrointestinal tract. Dermatologists and rheumatologists usually manage Pso and PsA separately, but early diagnosis and integrated management could achieve better outcomes of both skin and musculoskeletal manifestations, thus improving the health-related quality of life (HRQoL) of patients. In this work, we have described a model of integrated dermo-rheumatologic approach for the early diagnosis of PsA and to present the outcomes of the multidisciplinary management of PsA patients after 48 weeks of follow-up...
July 29, 2018: Clinical Rheumatology
Jesús Sanz Sanz, Emma Beltrán, M Consuelo Díaz-Miguel Pérez, Cristina Fernández-Carballido, Eva Galíndez, Carlos García Porrua, Jordi Gratacós, Julio Medina, Rubén Queiro, Julio Ramírez, Delia Reina, Carlos Rodríguez Lozano, Fernando José Rodríguez Martínez, Esteban Rubio, Raúl Veroz
OBJECTIVE: To generate a quality standard for the management of patients with psoriatic arthritis (PsA). METHODS: We employed qualitative methodology that included: 1) Two focus groups (one with patients with PsA and another with non-rheumatologist specialists involved in the care of PsA patients); 2) A narrative literature review of published documents related to the quality of care in PsA; 3) A nominal group meeting in which 15 expert rheumatologists generated and reached a consensus on a series of quality criteria, as well as formulas or quantifiable objective measures to evaluate them; 4) The Delphi method to establish the feasibility, priority and agreement with the quality criteria; 5) A final generation of standards of care and their attributes...
July 24, 2018: Reumatología Clinica
Eleni Kampylafka, Isabelle d'Oliveira, Christina Linz, Veronika Lerchen, Fabian Stemmler, David Simon, Matthias Englbrecht, Michael Sticherling, Jürgen Rech, Arnd Kleyer, Georg Schett, Axel J Hueber
BACKGROUND: Although the effects of interleukin-17A (IL-17A) inhibition on the signs and symptoms of psoriatic arthritis (PsA) are well defined, little is known about its impact of local inflammatory and structural changes in the joints. The PSARTROS study was designed to elucidate the effects of IL-17A inhibition on inflammation and bone changes in joints affected by PsA. METHODS: This was a prospective open-label study in 20 patients with active PsA receiving 24 weeks of treatment with the IL-17A inhibitor secukinumab...
July 27, 2018: Arthritis Research & Therapy
Joseph F Merola, Vivian Herrera, Jacqueline B Palmer
This study assessed the comorbidity burden and direct healthcare costs associated with psoriatic arthritis (PsA). Adults (18-64 years) with ≥ 2 claims for a PsA diagnosis ≥ 30 days apart in the Truven Health MarketScan database (July 2009-June 2014) were selected as the case group. The index date was randomly selected after the first claim for PsA. Controls free of PsA and psoriasis (PsO) in their entire claims history were assigned the same index date and were matched with the cases on age, gender, and geographic region...
July 26, 2018: Clinical Rheumatology
Satohiro Matsumoto, Hirosato Mashima
Anti-TNFα drugs have been shown to be effective for maintaining stable remission in patients with Crohn's disease. However, some problems have been identified during clinical use of this class of drugs, such as secondary treatment failure, in which the drugs become progressively less effective with time, and the development of paradoxical reactions such as psoriatic skin symptoms. Thus, while anti-TNFα drugs are used to treat psoriasis, they can sometimes also cause paradoxical psoriasis, characterized by the appearance of psoriasis-like eruptions, which has recently begun to attract attention...
2018: Biologics: Targets & Therapy
David Simon, Arnd Kleyer, Matthias Englbrecht, Fabian Stemmler, Christoph Simon, Andreas Berlin, Roland Kocijan, Judith Haschka, Simon Hirschmann, Raja Atreya, Markus F Neurath, Michael Sticherling, Juergen Rech, Axel J Hueber, Klaus Engelke, Georg Schett
Chronic inflammatory diseases are associated with bone loss. While the occurrence of systemic bone loss is well described in chronic inflammatory diseases, the impact of these conditions on articular bone has not been systematically investigated. Recent refinements in high-resolution CT assessment of the joints now allow the accurate measure of articular bone composition. In this study 476 subjects comprising healthy individuals and patients with anticitrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA), ACPA-negative RA, Crohn's disease (CD), ulcerative colitis (UC), psoriasis (PsO) and psoriatic arthritis (PsA) were subjected to high-resolution quantitative computed tomography (HR-pQCT) of the hand...
July 23, 2018: Bone
Arianna Zhang, Drew J B Kurtzman, Lourdes M Perez-Chada, Joseph F Merola
Psoriatic arthritis is a common form of inflammatory arthritis that frequently accompanies psoriasis of the skin-up to 30% of patients with psoriasis are affected. Recognition of the clinical features of psoriatic arthritis is critical, as delayed detection and untreated disease may result in irreparable joint injury, impaired physical function, and a significantly reduced quality of life. Recent epidemiologic studies have also supported that psoriatic arthritis is associated with cardiometabolic and cerebrovascular comorbidities, including coronary heart disease, diabetes mellitus, hypertension, dyslipidemia, and cerebrovascular accidents, further highlighting the importance of identifying affected patients...
July 2018: Clinics in Dermatology
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