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Thymoma Classification

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https://www.readbyqxmd.com/read/30016438/video-assisted-thoracoscopic-surgery-versus-open-surgery-for-stage-i-thymic-epithelial-tumours-a-propensity-score-matched-study
#1
Zhitao Gu, Chun Chen, Yun Wang, Yucheng Wei, Jianhua Fu, Peng Zhang, Yongyu Liu, Renquan Zhang, Keneng Chen, Zhentao Yu, Liewen Pang, Yangchun Liu, Yin Li, Yongtao Han, Hezhong Chen, Xinming Zhou, Youbin Cui, Lijie Tan, Jianyong Ding, Yi Shen, Yuan Liu, Wentao Fang
OBJECTIVES: Video-assisted thoracoscopic surgery (VATS) has been increasingly used in the management of thymic epithelial tumours. However, its oncological efficacy remains to be proved. The purpose of this study is to compare the oncological outcomes following thoracoscopic versus open surgery in the case-matched groups of patients with early-stage thymic tumours from the Chinese Alliance for Research in Thymomas (ChART) retrospective database. METHODS: Between 1994 and 2012, a total of 1087 patients who underwent surgery for UICC (Union for International Cancer Control) pathological Stage I tumours from the ChART retrospective database were recruited for this study...
July 16, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29997965/inter-relationship-among-myasthenia-gravis-who-histology-and-masaoka-clinical-stage-and-effect-on-surgical-methods-in-patients-with-thymoma-a-retrospective-cohort-study
#2
Jianfei Shen, Hongtao Tie, Anyi Xu, Dan Chen, Dehua Ma, Bo Zhang, Chengchu Zhu, Qingchen Wu
Background: The aim of study is to analyze the inter-relationship among WHO histology, myasthenia gravis (MG) and Masaoka stage and to assess the feasibility of thoracoscopic surgery in thymoma patients. Methods: Data from 142 consecutive thymoma patients from January 2009 to March 2016 were retrospectively reviewed in our institution. Histological classification and clinical staging were assessed by WHO histology criteria and Masaoka stage. We investigated the clinical characteristics, inter-relationship among WHO histology, MG and Masaoka stage, and compared the feasibility and safety of thoracoscopic thymectomy by comparison of open thymectomy...
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29983810/surgery-resection-of-a-massive-thymic-carcinoma-during-urgent-coronary-artery-bypass-grafting
#3
Selman Dumani, Ermal Likaj, Aferdita Veseli, Stavri Llazo, Leart Berdica, Ali Refatllari
BACKGROUND: Thymic carcinoma is a very rare tumour. It is classified as thymoma type C according to World Health Organization classification. There are not many publications of simultaneous surgical treatment of thymoma during cardiac surgery interventions. CASE REPORT: We present a case of simultaneous surgical treatment of incidentally discovered thymic carcinoma during an urgent coronary artery by-pass operation. A 55-year-old man with diagnosis three coronary vessel diseases indicated urgent by-pass surgery...
June 20, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29977769/good-s-syndrome-with-clinical-manifestation-after-thymectomy-a-case-report
#4
Ryutaro Furukawa, Masahiro Yanagiya, Jun Matsumoto, Hirotsugu Hashimoto, Hajime Horiuchi, Kazuhiro Usui
Good's syndrome is a rare condition of immunodeficiency that is characterized by thymoma and hypogammaglobulinemia. A 74-year-old Japanese woman underwent total thymothymectomy for type AB thymoma (2015 WHO classification). She developed recurrent infectious diseases caused by Escherichia coli (bacteremia), Streptococcus pneumoniae (pneumonia and bacteremia) and Pseudomonas aeruginosa (bacteremia) in the year after thymectomy. The serum levels of immunoglobulin were significantly low (IgG 157mg/dL), which suggested that her infectious diseases were associated with Good's syndrome...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29778330/lymph-node-metastasis-in-thymic-malignancies-a-chinese-multicenter-prospective-observational-study
#5
Wentao Fang, Yun Wang, Liewen Pang, Zhitao Gu, Yucheng Wei, Yongyu Liu, Peng Zhang, Chun Chen, Xinming Zhou, Yangchun Liu, Keneng Chen, Jianyong Ding, Yongtao Han, Yin Li, Zhentao Yu, Yuan Liu, Jianhua Fu
OBJECTIVES: To study the incidence and pattern of lymph node metastases in thymic malignancies. METHODS: This multicenter prospective observational trial with intentional lymph node dissection was carried out by the Chinese Alliance for Research in Thymomas (ChART). Data on patients with thymic tumors without pretreatment were collected prospectively. Results from this prospective study were then compared with those from a previously reported ChART retrospective study...
August 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29775980/-comparison-of-the-masaoka-koga-classification-with-the-new-tnm-staging-of-the-iaslc-itmig-for-thymoma-and-thymic-carcinoma
#6
Michael Ried, Maria-Magdalena Eicher, Reiner Neu, Dietmar Kraus, Sebastian Inderhees, Alexander Marx, Hans-Stefan Hofmann
BACKGROUND: The Masaoka-Koga classification describes the extent and spread of thymic epithelial malignancies. The objective of this study was to evaluate the Masaoka-Koga and the new TNM-staging system regarding differences in stage distributions, clinical implementation and therapeutic consequences. METHODS: Retrospective analysis of all patients who underwent surgery between January 2005 and December 2015 for thymoma/thymic carcinoma in two centres for thoracic surgery...
May 18, 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29682176/high-ctla-4-expression-correlates-with-poor-prognosis-in-thymoma-patients
#7
Giorgio Santoni, Consuelo Amantini, Maria Beatrice Morelli, Daniele Tomassoni, Matteo Santoni, Oliviero Marinelli, Massimo Nabissi, Claudio Cardinali, Vittorio Paolucci, Mariangela Torniai, Silvia Rinaldi, Francesca Morgese, Giovanni Bernardini, Rossana Berardi
Thymomas, tumors that arise from epithelial cells of the thymus gland, are the most common neoplasms of the anterior mediastinum, with an incidence rate of approximately 2.5 per million/year. Cytotoxic T Lymphocyte Antigen 4 (CTLA-4 or CD152) exerts inhibitory activity on T cells, and since its oncogenic role in the progression of different types of tumors, it has emerged as a potential therapeutic target in cancer patients. In this study, we assessed the expression of CTLA-4 both at mRNA and protein levels in paraffin embedded-tissues from patients with thymomas...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29681772/thymic-tumors-and-results-of-radiotherapy
#8
Sureyya Sarıhan, Ahmet Sami Bayram, Cengiz Gebitekin, Omer Yerci, Deniz Sıgırlı
Aim: The aim of this study was to evaluate thymic epithelial tumors (TETs) for treatment outcomes and prognostic factors on survival. Background: TETs are very rare neoplasms and multidisciplinary approach is recommended according to prognostic factors. Materials and methods: Between 1995 and 2013, 31 patients were treated with median 5400 cGy (range: 1620-6596 cGy) radiotherapy (RT). Eleven patients received adjuvant or concurrent chemotherapy...
March 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29626459/an-unusual-invasive-ectopic-thymoma-in-the-thyroid-and-anterior-mediastinum
#9
Haruaki Hino, Jun-Ichi Nitadori, Keiko Ohno, Seiji Kishimoto, Masatoki Takahashi, Mototsune Kakizaki, Tomio Arai, Takashi Nishimura, Jun Nakajima
An 81-year-old woman with a 2-year history of dysphagia detected a cervical mass. Computed tomography showed a thyroid tumor extending through the superior and anterior mediastinum. Analysis of an incisional biopsy specimen revealed a thymoma. Total resection of the thyroid and mediastinal tumor was performed. The thymoma invaded the anterior tracheal wall and left brachiocephalic vein. Pathologic examination revealed thymoma type B1 concomitant with B2 and B3 (World Health Organization classification), Masaoka IVb, and T3 N2 M0-IVb, with cervical lymph node metastasis...
August 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29613961/mr-imaging-of-thymic-epithelial-neoplasms
#10
REVIEW
Brett W Carter, John P Lichtenberger, Marcelo F Benveniste
Thymic epithelial neoplasms are malignant lesions that originate from the thymus and include thymoma, thymic carcinoma, and thymic neuroendocrine tumors. Although computed tomography (CT) is typically considered the imaging modality of choice for identifying thymic tumors, characterizing the primary neoplasm, and staging of disease, the role of magnetic resonance (MR) imaging continues to expand. MR imaging is effective in distinguishing thymic epithelial neoplasms and other malignant tumors from benign lesions in the prevascular mediastinum, can be used to characterize and stage thymic tumors in those patients with contraindications to contrast-enhanced CT, and can reveal morphologic features of thymic tumors...
April 2018: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/29435030/focal-adhesion-kinase-is-overexpressed-in-thymic-epithelial-tumors-and-may-serve-as-an-independent-prognostic-biomarker
#11
Meng Li, Feng Hou, Jie Zhao, Tianqiang Zhang, Dongfei Li, Wensi Wu, Xiaotong Liu, Linhao Xu
Focal adhesion kinase (FAK) has long been considered to be a key regulator of growth factor receptor- and integrin-mediated signals, with pivotal roles in tumor cells through its kinase activity and scaffolding function. Increased FAK expression and activity has been observed in tumors of various origins and is often associated with a poor prognosis. However, there have been no studies on the aberrant expression of FAK in thymic epithelial tumors to date. The aim of the present study was to evaluate FAK expression in thymic epithelial tumors and to explore the prognostic significance of FAK...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29357966/-clinical-study-on-the-prognosis-of-patients-with-thymoma-with-myasthenia-gravis
#12
Dongfeng Yuan, Zhitao Gu, Guanghui Liang, Wentao Fang, Yin Li
BACKGROUND: Thymoma is frequently associated with myasthenia gravis (MG). However, whether MG is a factor for the outcome of patients with thymoma following complete thymectomy remains unknown. The aim of this study is to investigate the effect of thymoma with MG prognostic factors. METHODS: A retrospective analysis of The Chinese Alliance for Research in Thymomas (ChART) database within 1992-2012 complete cases 875 cases, 20 years follow-up data analysis thymic tumor tissue type credits and MG, Masaoka staging and prognosis, postoperative adjuvant therapy and relationship with the prognosis of surgical removal of the way...
January 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29307077/analysis-of-ct-features-and-quantitative-texture-analysis-in-patients-with-thymic-tumors-correlation-with-grading-and-staging
#13
Angelo Iannarelli, Beatrice Sacconi, Francesca Tomei, Marco Anile, Flavia Longo, Mario Bezzi, Alessandro Napoli, Luca Saba, Michele Anzidei, Giulia D'Ovidio, Roberto Scipione, Carlo Catalano
OBJECTIVES: To evaluate potential relationship between qualitative CT features, quantitative texture analysis (QTA), histology, WHO staging, Masaoka classification and myasthenic syndrome in patients with thymic tumors. MATERIALS AND METHODS: Sixteen patients affected by histologically proven thymic tumors were retrospectively included in the study population. Clinical information, with special regard to myasthenic syndrome and serological positivity of anti-AchR antibodies, were recorded...
May 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29260882/histogram-analysis-of-apparent-diffusion-coefficient-maps-for-assessing-thymic-epithelial-tumours-correlation-with-world-health-organization-classification-and-clinical-staging
#14
Ling-Yan Kong, Wei Zhang, Yue Zhou, Hai Xu, Hai-Bin Shi, Qing Feng, Xiao-Quan Xu, Tong-Fu Yu
OBJECTIVE: To investigate the value of apparent diffusion coefficients (ADCs) histogram analysis for assessing World Health Organization (WHO) pathological classification and Masaoka clinical stages of thymic epithelial tumours. METHODS: 37 patients with histologically confirmed thymic epithelial tumours were enrolled. ADC measurements were performed using hot-spot ROI (ADCHS-ROI ) and histogram-based approach. ADC histogram parameters included mean ADC (ADCmean ), median ADC (ADCmedian ), 10 and 90 percentile of ADC (ADC10 and ADC90 ), kurtosis and skewness...
April 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29221974/criteria-for-postoperative-mechanical-ventilation-after-thymectomy-in-patients-with-myasthenia-gravis-a-retrospective-analysis
#15
Keerthi Chigurupati, Shrinivas Gadhinglajkar, Rupa Sreedhar, Muraleedharan Nair, Madathipat Unnikrishnan, Manjusha Pillai
OBJECTIVE: To determine the criteria for postoperative mechanical ventilation after thymectomy in patients with Myasthenia Gravis. DESIGN: Retrospective study. SETTING: Teritiary care centre. PARTICIPANTS: 77 Myasthenia gravis patients operated for thymectomy were studied. INTERVENTIONS: After obtaining clearance from Institutional ethics committee, medical records of 77 patients with MG, who were operated for thymectomy between January 2005 and December 2015 were reviewed in a retrospective manner...
February 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29221349/ab-thymoma-with-atypical-type-a-component-with-delayed-multiple-lung-and-brain-metastases
#16
Wieslawa Grajkowska, Ewa Matyja, Jacek Kunicki, Sylwia Szymanska, Alexander Marx, Cleo-Aron Weis, Renata Langfort, Malgorzata Szolkowska
An atypical type A thymoma is a newly added entity to the last World Health Organization (WHO) histological classification [2015] of uncertain prognosis. The conventional type A and AB thymomas are usually locally aggressive neoplasms that rarely metastasize with distant metastases to the central nervous system (CNS) occurring extremely exceptionally. We present a history of a woman with a mediastinal tumor originally considered to be a Masaoka-Koga stage II "mixed thymoma with well-differentiated thymic carcinoma component" according to the historic Müller-Hermelink nomenclature...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221348/lung-metastases-in-an-atypical-type-a-thymoma-variant
#17
Masaki Hashimoto, Yoshitane Tsukamoto, Shohei Matsuo, Toru Nakamichi, Nobuyuki Kondo, Seiki Hasegawa
A 35-year-old woman had undergone extensive thymothymectomy for type A thymoma several years ago. However, two small lung nodules were found 4 and 5 years after surgery. After a partial lung resection to remove these nodules, pathology revealed that they were metastases of the type A thymoma. A pathological re-evaluation confirmed that the primary tumor had in fact been an atypical type A thymoma variant, a subset added to the WHO classification in 2015. Pathology should be re-evaluated in all patients diagnosed with type A thymoma before 2015 since they may have the more aggressive atypical type A thymoma variant...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29201452/neuroendocrine-tumors-of-the-thymus-the-oncologist-point-of-view
#18
REVIEW
Nicolas Girard
Thymic malignancies represent a heterogeneous group of rare thoracic cancers, which are classified according to the World Health Organization (WHO) histopathologic classification that distinguishes thymomas from thymic carcinomas and neuroendocrine tumors; neuroendocrine thymic tumors (NETTs) exhibit the same histological spectrum as in other anatomical locations, although with different frequencies. NETTs represent around 2% of all neuroendocrine tumors, and about 5% of all thymic malignancies. Overall, the management of patients with NETTs tumors requires continuous multidisciplinary expertise at any step of the disease progression...
November 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29156018/risk-factors-of-myasthenic-crisis-after-thymectomy-for-thymoma-patients-with-myasthenia-gravis
#19
Liang Xue, Lin Wang, Jihong Dong, Yunfeng Yuan, Hong Fan, Yi Zhang, Qun Wang, Jianyong Ding
OBJECTIVES: Total thymectomy should be performed on thymoma patients with myasthenia gravis. The aim of the present study was to investigate the risk factors of postoperative myasthenic crisis (POMC) occurrence in these patients. METHODS: The clinical records of 127 thymoma patients with myasthenia gravis (68 men, 59 women; median age, 50 years) who underwent total thymectomy at our institution from 2005 to 2014 were retrospectively reviewed. The following factors were analysed in relation to POMC: gender, age, duration of symptoms, bulbar symptoms, smoking history, history of myasthenic crisis, comorbidities, perioperative pyridostigmine and prednisolone therapy, spirometric and blood gas parameters, Osserman stage, operation approach, major complications, World Health Organization (WHO) histologic classification, Masaoka stage and use of immunoglobulins or plasmapheresis...
October 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29078617/surgical-and-oncological-outcomes-of-thoracoscopic-thymectomy-for-thymoma
#20
REVIEW
Makoto Odaka, You Tsukamoto, Takamasa Shibasaki, Shohei Mori, Hisatoshi Asano, Makoto Yamashita, Toshiaki Morikawa
Thymoma remains the most common primary anterior mediastinal neoplasm. Surgical resection remains central to the treatment of thymoma, with thoracoscopic thymectomy (TT) being increasingly performed. This present review article aimed to summarize current studies comparing TT and open thymectomy (OT). Recently, most patients with Masaoka stage I-II thymoma have been receiving TT. This procedure is associated with a significantly shorter post-operative hospital stay, decreased intraoperative blood loss, and fewer complications compared with OT...
2017: Journal of Visualized Surgery
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