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Sjors Klompmaker, Ugo Boggi, Thilo Hackert, Roberto Salvia, Matthew Weiss, Hiroki Yamaue, Herbert J Zeh, Marc G Besselink
Approximately 30% of all pancreatic cancer patients have locally advanced (AJCC stage 3) disease. A sub-group of these patients-where the cancer only involves the celiac axis-may benefit from distal pancreatectomy with celiac axis resection (DP-CAR). Previous studies have shown that DP-CAR offers a survival benefit to a selected group of patients with otherwise unresectable pancreatic cancer, when performed by experienced pancreatic cancer treatment teams at high-volume centers. This article proposes a standardized approach to DP-CAR, including routine neoadjuvant (FOLFIRINOX) chemotherapy...
August 13, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Ugo Pace, Alessia Passanisi, Giulio D'Urso
INTRODUCTION: The phenomenon of hate is becoming common among adolescents, but is little investigated by literature. Typically the haters leave their insults on the victim's social pages to denigrate another person, famous or not. In the literature, to date, there are no scientific studies that have explored psychological variables linked to these behaviors. The aim of this study was to evaluate the psychological correlates of pathological worry and cognitive distortions (CD) related to hating behaviors...
August 8, 2018: Journal of Adolescence
F Hassannia, S D Carr, G-M Busato, J A Rutka
OBJECTIVE: To report two cases of transmastoid clipping of a sigmoid sinus diverticulum. METHODS: Two patients with pulsatile tinnitus resulting from a sigmoid sinus diverticulum underwent clipping at the diverticulum neck using intra-operative Doppler ultrasonography. RESULTS: At six months' follow up, both patients reported complete resolution of pulsatile tinnitus with no complications. CONCLUSION: Transmastoid clipping of a sigmoid sinus diverticulum can be a safe and effective method of managing pulsatile tinnitus resulting from a sigmoid sinus diverticulum...
August 6, 2018: Journal of Laryngology and Otology
Anees B Chagpar
No abstract text is available yet for this article.
July 2018: Clinical Advances in Hematology & Oncology: H&O
Jae-Hyun Park, Je-Tae Jung, Sang-Jin Lee
BACKGROUND: Surgeries for far-lateral lumbar disc herniation (FLLDH) and foraminal stenosis at the L5/S1 level are very complicated because of its unique structure. The authors have performed unilateral bi-portal endoscopy (UBE) to these lesions because of the good results obtained for other spinal diseases (Park et al. in Orthopedics 40:e779-e783, 2017). METHODS: We described our experience of the surgical treatment for FLLDH and foraminal stenosis. Useful information for pre-, intraop-, and postoperative care is presented...
July 31, 2018: Acta Neurochirurgica
Sorin Aldea, Pierre-Cyril Cômes, Stephan Gaillard
BACKGROUND: The eyebrow approach is a keyhole technique that gives a wide access to the anterior circle of Willis. METHODS: A 4-cm linear incision is placed in the upper limit of the eyebrow and a small supraorbital bone flap is raised. A wide arachnoid dissection is essential to maximize the working space. One or multiple aneurysms may be treated by the same approach. CONCLUSIONS: The eyebrow approach is a safe technique for selected aneurysms of the anterior circle of Willis...
July 26, 2018: Acta Neurochirurgica
G Chene, K Lebail-Carval, C Azzi, P Chabert, G Mellier, G Lamblin
No abstract text is available yet for this article.
July 2018: Gynecologie, Obstetrique, Fertilite & Senologie
Francisco Schlottmann, Fernando A M Herbella, Marco G Patti
Gastroesophageal reflux disease (GERD) affects an estimated 20% of the population in the US, and its prevalence is increasing worldwide. Lifestyle modifications and proton pump inhibitors (PPI) are effective in the majority of patients. However, some patients will become candidates for surgical intervention, because they have partial control of symptoms, do not want to be on long-term medical treatment, or suffer complications related to PPI. In these patients, a properly executed laparoscopic antireflux surgery controls esophageal and extra-esophageal symptoms and avoids life-long medical therapy...
July 23, 2018: Updates in Surgery
Y J Chang, X J Huang
No abstract text is available yet for this article.
June 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
A B Liang, P Li
No abstract text is available yet for this article.
June 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Kristofer M Charlton-Ouw, Anthony L Estrera
No abstract text is available yet for this article.
July 17, 2018: Annals of Thoracic Surgery
Verena Müller, Martina Mogl, Philippa Seika, Thomas Jöns, Igor Sauer, Johann Pratschke, Angkoon Anuwong, Ricardo Zorron
BACKGROUND: Minimally invasive thyroid and parathyroid resections are rarely performed. Promising new endoscopic transoral approaches to the anterior neck (transoral endoscopic thyroidectomy vestibular approach [TOETVA]) have been described with good results and few complications. This study evaluates a new device to allow the safe entrance of trocars in the subplatysmal space for TOETVA in a cadaver model. METHODS: The technique was performed in 4 unilateral thyroidectomies in female cadavers...
July 1, 2018: Surgical Innovation
Rumdeep K Grewal, Shradha Saraf, Arindam Deb, Sudip Kundu
Plant microRNA (miRNA) and their target genes have important functional roles in nutrition deficiency and stress response. However, the underlying mechanisms relating relative expressions of miRNAs and target mRNAs to morphological adjustments are not well defined. Combining miRNA expression profiles, corresponding target genes and transcription factors that bind to computationally identified over-represented CREs common in miRNAs and target gene promoters, we implement a strategy that identifies a set of differentially expressed regulatory interactions, which, in turn, relate underlying cellular mechanisms to some phenotypic changes observed...
July 14, 2018: Plant & Cell Physiology
Jason A Jepson
No abstract text is available yet for this article.
July 2, 2018: Schizophrenia Bulletin
Lisa Giulino-Roth
The WHO now recognizes primary mediastinal B-cell lymphoma (PMBCL) as a unique clinical and biologic entity. PMBCL is distinct from other B-cell non-Hodgkin lymphoma subtypes and has features that overlap with classical Hodgkin lymphoma including a peak incidence in the adolescent and young adult population; mediastinal presentation of disease, and molecular alterations in JAK2 and programmed death ligands. Since PMBCL is rare, there are few prospective clinical trials to guide therapy, resulting in no single standard of care...
July 5, 2018: Blood
Sara Gandolfi, Claudia Paba Prada, Paul Richardson
The treatment landscape for multiple myeloma has been transformed by the introduction of novel agents, including immunomodulatory drugs, proteasome inhibitors, and monoclonal antibodies. These have been shown to be more effective and generally better tolerated than conventional chemotherapy, with their introduction into clinical practice leading to improved survival. Furthermore, a better understanding of disease biology, improved diagnostic criteria, as well as the development of sensitive and specific tools for disease prognostication have contributed to better outcome...
July 2, 2018: Blood
Mariia Burdyniuk, Natalia Wesolowska, Michal Fleszar, Matthia A Karreman, Pedro Machado, Joana Borrego-Pinto, Bernhard Ruthensteiner, Yannick Schwab, Péter Lénárt
The rapid and synchronous divisions of large and transparent oocytes, eggs, and embryos of marine species are exceptionally well suited for microscopic observation. Consequently, these cells have been models for cell division research since its beginnings and contributed some of its first and most fundamental discoveries. While large size and rapid transitions render these cells ideal specimens for light microscopy, the same features constitute a challenge for electron microscopy. Here, we describe example protocols from our work on starfish oocyte meiosis, where we overcome these challenges by using live imaging of fluorescently labeled structures in combination with correlated electron microscopy...
2018: Methods in Cell Biology
Menaka Sarav, Csaba Pal Kovesdy
No abstract text is available yet for this article.
June 28, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Catherine G Banks, Jaime A P Garcia, Jessica Grayson, Do Yeon Cho, Bradford A Woodworth
Background The osteoplastic flap provides access to pathology of the frontal sinus and is often performed with obliteration, which can result in significant long-term complications. Objective To describe the authors' approach to osteoplastic flap without obliteration. Methods Descriptive analysis. Results Osteoplastic flap without obliteration preserves frontal sinus function while permitting direct access to the frontal sinus. In this study, we demonstrate a combined nonobliterated approach, accessing the frontal sinus with a Draf III approach to remove a large frontal sinus osteoma...
January 1, 2018: American Journal of Rhinology & Allergy
E Larouzée, A Arfi, L Allègre, S Bendifallah, E Darai, S Zilberman
No abstract text is available yet for this article.
July 2018: Gynecologie, Obstetrique, Fertilite & Senologie
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