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G Résimont, R Gadisseur, L Lutteri, J M Krzesinski, E Cavalier, P Delanaye
The measurement of proteinuria is a very simple tool to screen and manage kidney diseases. Its predictive role is also relevant from a cardiovascular point of view. However, the interpretation of the results is not always easy. Indeed, there are several different methods to detect or measure proteinuria (or albuminuria), varying from the measurement on a 24-hour urine collection to the simplest detection with dipsticks or measurement on a random urine sample. Some methods are measuring total proteins, whereas others are measuring more specifically albuminuria...
October 2018: Revue Médicale de Liège
A J Scheen
Drug therapy failure may occur with any medical intervention. It is badly accepted by both the physician and the patient. Drug failure may be attributed to the physician, the patient, the medication or the severity of the disease itself. Once drug failure is confirmed, causes should rapidly be identified in order to find a solution because several ones may often be offered.
October 2018: Revue Médicale de Liège
Olatoyosi Odenike
The classic Philadelphia chromosome negative myeloproliferative neoplasms (Ph -MPNs) are a heterogeneous group of hematopoietic stem cell diseases, characterized by activated JAK/STAT signaling, significant phenotypic mimicry, including a propensity for evolution to myeloid blast phase disease. Effective therapeutic options are limited for patients with Ph-MPNs in the blast phase (MPN-BP), and allogeneic stem cell transplant is the only known cure. Our increasing understanding of the molecular pathogenesis of this group of diseases, coupled with the increasing availability of targeted agents, has the potential to inform new subset specific therapeutic approaches...
October 17, 2018: Blood
Meaghann S Weaver, Wendy G Lichtenthal, Kara Larson, Lori Wiener
Bereaved families fear their child being forgotten by those who knew their loved child, including their child's oncology team. Thoughtfully timed, family-centric condolences shared by pediatric oncology team members have the potential to extend our compassion and kindness toward a family during the darkness of grief. Well-intended medical teams sometimes feel "at a loss" in terms of what to say to a grieving family and how or when to say it. This paper provides a tangible overview of written or verbal condolence communication in a format that can be personalized to the provider and the patient's family...
October 14, 2018: Pediatric Blood & Cancer
Jean-Louis Vincent
No abstract text is available yet for this article.
October 12, 2018: Intensive Care Medicine
Juliana Nishimura Bueno, Cinira Assad Simão Haddad, Samantha Karlla Lopes De Almeida Rizzi, Patricia Santolia Giron, Gil Facina, Afonso Celso Pinto Nazário
OBJECTIVE: Breast cancer is one of the most common types of tumor in the world and the most common among women. There are several treatments for breast cancer; however, the condition often can be accompanied by severe complications in a woman's life. To evaluate and compare body image perception, quality of life, tenderness, and pain in women with breast cancer during preoperative and postoperative periods of 30, 60 and 90 days. MATERIALS AND METHODS: We conducted a prospective longitudinal study...
June 2018: Revista da Associação Médica Brasileira
Meghan Delaney
No abstract text is available yet for this article.
October 4, 2018: Transfusion
Gilles Manceau, Viriane Tan, Omar Ahmed, Jean Michel Siksik, Jean Christophe Vaillant, Mehdi Karoui
No abstract text is available yet for this article.
October 2, 2018: ANZ Journal of Surgery
I Jardin, C Louis-Vahdat, G Canlorbe, J-L Mergui, C Uzan, H Azaïs
No abstract text is available yet for this article.
September 25, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
Taiga Wakabayashi, Emanuele Felli, Patrick Pessaux
INTRODUCTION: Some articles have recently shown that robotic pancreaticoduodenectomy (PD) is feasible and can be a safe method. On the other hand, pancreatic fistulas (PF) remain the most dreaded complication after PD, and a secured pancreaticoenteric reconstruction may be essential in this regard. Previous articles have highlighted the usefulness of telescoped pancreaticogastrostomy (PG) in open PD to reduce the risk of postoperative PF. Additionally, in 2016, Addeo et al. described a double purse-string telescoped PG (DPS-PG), simplified from previous techniques, with favorable short-term results...
September 25, 2018: World Journal of Surgery
Paul E Terry
How do we judge whether our profession is meeting its potential when, according to time honored definitions of health promotion, we consider health to be a byproduct of culture and we deem some aspects of culture to be prerequisites to health? If our profession falls short, is it because we are not doing enough to change the world? This editorial previews a new model for health promotion called "collective well-being." Collective well-being is less about how I cope with society to reach my potential and more about how we cocreate a society that enables us all to thrive...
September 25, 2018: American Journal of Health Promotion: AJHP
Courtney D Thornburg
Previously untreated patients with severe hemophilia A are a vulnerable population at risk for severe bleeding which is currently managed with exogenous clotting factor replacement. The primary burden of current treatment is high-titer inhibitor development. Evolving data on current treatment products as well as emerging therapeutics may inform treatment decisions to prevent bleeding and inhibitor formation. Considerations for diagnosis, education, and shared decision-making related to product choice and treatment regimen are discussed...
September 24, 2018: Pediatric Blood & Cancer
Guillaume Vignon, Roxane Jeanneau, Julien Labrousse, Sébastien Aubrit, Philippe Mottaz, François Carrère, Pierre-Frédéric Augereau, Philippe Aucher, Franck Lellouche
The most frequent causes of hemolytic anemias are immune or infectious diseases, drug induced hemolysis, thrombotic microangiopathies, hereditary spherocytosis, glucose-6-phosphate dehydrogenase or pyruvate kinase deficiencies, thalassemia's and sickle cell disease. Sometimes no cause is found because a rarer etiology is involved. The goal of this review is to remember some unfrequent constitutional or acquired causes and to point out difficulties to avoid wrong interpretations of analysis results.
October 1, 2018: Annales de Biologie Clinique
Kamal Kant Sharma, Jan K Marzinek, Sarala Neomi Tantirimudalige, Peter J Bond, Thorsten Wohland
Flaviviruses are simple enveloped viruses exhibiting complex structural and functional heterogeneities. Decades of research have provided crucial basic insights, antiviral medication and moderately successful gene therapy trials. The most infectious particle is, however, not always the most abundant one in a population, questioning the utility of classic ensemble-averaging virology approaches. Indeed, viral replication is often not particularly efficient, prone to errors or containing parallel routes. Here, we review different single-molecule sensitive fluorescence methods that are employed to investigate flaviviruses...
September 14, 2018: Progress in Biophysics and Molecular Biology
Christopher R Morse
No abstract text is available yet for this article.
September 14, 2018: Annals of Thoracic Surgery
Bethany Radecki, Staci Reynolds, Areeba Kara
AIM: The aim of this study was to describe the patient's perspective of fall prevention in an acute care setting to aid in the design of patient centered strategies. BACKGROUND: Falls are one of the most common adverse events in hospitals and can lead to preventable patient harm, increased length of stay, and increased healthcare costs. There is a need to understand fall risk and prevention from the patients' perspectives; however, research in this area is limited...
October 2018: Applied Nursing Research: ANR
Sakina Jaffrey
In November 2016, I was awarded an Emerging Leaders Scholarship from the Florence Nightingale Foundation to help me positively impact patient care and also improve how I lead change within my organisation. This article highlights some of the learning experiences over the last year and the impact that the Scholarship has had.
September 13, 2018: Journal of Perioperative Practice
Neha Mehta-Shah, Mark W Clemens, Steven M Horwitz
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a recently described form of T-cell non-Hodgkin lymphoma now formally recognized by the World Health Organization classification of lymphoid neoplasms. The disease most often presents with a delayed seroma around the breast implant, almost exclusively one with a textured surface, and manifests with breast pain, swelling or asymmetry, capsular contracture, but can also present with a breast mass, and lymph node involvement. The prognosis of BIA-ALCL is favorable compared to many other subtypes of systemic T-cell lymphoma, however unlike other non-Hodgkin lymphomas, complete surgical excision for localized disease is an important part of the management of these patients...
September 12, 2018: Blood
Lorenzo Bertulli, Michael Reinert, Thomas Robert
BACKGROUND: Posterior communicating artery aneurysms sometimes present with partial or complete oculomotor nerve palsy, due to direct oculomotor nerve compression, irritation by subarachnoid blood, or both. Superiority of surgical clipping over endovascular coiling in terms of postoperative outcome is still controversial. METHOD: Direct oculomotor nerve decompression by opening of the anterior petroclinoid ligament during aneurysm clipping is performed as a simple and feasible surgical maneuver which allows to improve the decompression effect obtained by aneurysm exclusion...
September 8, 2018: Acta Neurochirurgica
Frederick M Ausubel
My trajectory to becoming a plant biologist was shaped by a complex mix of scientific, political, sociological, and personal factors. I was trained as a microbiologist and molecular biologist in the late 1960s and early 1970s, a time of political upheaval surrounding the Vietnam War. My political activism taught me to be wary of the potential misuses of scientific knowledge and to promote the positive applications of science for the benefit of society. I chose agricultural science for my postdoctoral work. Because I was not trained as a plant biologist, I devised a postdoctoral project that took advantage of my microbiological training, and I explored using genetic technologies to transfer the ability to fix nitrogen from prokaryotic nitrogen-fixing species to the model plant Arabidopsis thaliana with the ultimate goal of engineering crop plants...
September 7, 2018: Annual Review of Genetics
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