keyword
https://read.qxmd.com/read/38356428/-how-i-manage-polycythemia
#1
Gérôme Lombardo, Kaoutar Hafraoui, Yves Beguin, Gaëlle Vertenoeil
Polycythemia is suspected when hemoglobin and/or hematocrit levels exceed established norms based on gender and age. This biological anomaly can arise from a myeloproliferative neoplasm known as polycythemia vera, or be secondary to excess erythropoietin (EPO) or decreased in plasma volume. Faced with polycythemia, the search for JAK2 mutations and measurement of serum EPO levels can guide toward the etiology. In polycythemia vera, thromboembolic events are the most lethal complications and unfortunately often the initial manifestation of the disease...
February 2024: Revue Médicale de Liège
https://read.qxmd.com/read/38316359/how-i-manage-severe-bacterial-infections-in-people-who-inject-drugs
#2
REVIEW
Andrew J Stewardson, Joshua S Davis, Adrian J Dunlop, Steven Y C Tong, Gail V Matthews
BACKGROUND: Injecting drug use is a risk factor for severe bacterial infection, but there is limited high-quality evidence to guide clinicians providing care to people who inject drugs. Management can be complicated by mistrust, stigma, and competing patient priorities. OBJECTIVES: To review the management of severe infections in people who inject drugs, using an illustrative clinical scenario of complicated Staphylococcus aureus bloodstream infection. SOURCES: The discussion is based on recent literature searches of relevant topics...
February 3, 2024: Clinical Microbiology and Infection
https://read.qxmd.com/read/38232056/how-i-manage-acute-respiratory-failure-in-patients-with-hematological-malignancies
#3
JOURNAL ARTICLE
Elie Azoulay, Johan Maertens, Virginie Lemiale
Acute respiratory failure (ARF) is common in hematological malignancies patients, notably those with acute leukemia, myelodysplastic syndrome, or allogeneic stem-cell transplantation. ARF is the leading reason for intensive care unit (ICU) admission, with a 35% case fatality. Failure to identify the ARF cause is associated with mortality. A prompt well-designed diagnostic workup is crucial. The investigations are chosen according to pre-test diagnostic probabilities, estimated by the DIRECT approach: D stands for delay, or time since diagnosis; I for pattern of immune deficiency; R and T for radiological evaluation; The "E" refers to clinical experience and the C to the clinical picture...
December 14, 2023: Blood
https://read.qxmd.com/read/37995100/zon-rl-berliner-n-how-i-manage-inpatient-consultations-for-quantitative-neutrophil-abnormalities-in-adults-blood-2023-142-9-786-793
#4
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 23, 2023: Blood
https://read.qxmd.com/read/37891688/how-i-manage-differential-gas-exchange-in-peripheral-venoarterial-extracorporeal-membrane-oxygenation
#5
REVIEW
Richa Asija, Justin A Fried, Eric C Siddall, Dana A Mullin, Cara L Agerstrand, Daniel Brodie, Joshua R Sonett, Philippe H Lemaitre, Darryl Abrams
Dual circulation is a common but underrecognized physiological occurrence associated with peripheral venoarterial extracorporeal membrane oxygenation (ECMO). Competitive flow will develop between blood ejected from the heart and blood travelling retrograde within the aorta from the ECMO reinfusion cannula. The intersection of these two competitive flows is referred to as the "mixing point". The location of this mixing point, which depends upon the relative strengths of the native and extracorporeal pumps, will determine which regions of the body are perfused with blood ejected from the left ventricle and which regions are perfused by reinfused blood from the ECMO circuit, effectively establishing dual circulations...
October 27, 2023: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/37699660/how-i-manage-anticoagulation-of-krt-in-patients-with-acute-on-chronic-liver-failure
#6
JOURNAL ARTICLE
Thomas Demuynck, Alexander Wilmer, Björn Meijers
No abstract text is available yet for this article.
November 1, 2023: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/37606492/how-i-manage-chronic-lymphocytic-leukemia
#7
REVIEW
Patrice Nasnas, Claudio Cerchione, Gerardo Musuraca, Giovanni Martinelli, Alessandra Ferrajoli
Chronic lymphocytic leukemia (CLL), is a hematologic malignancy characterized by the uncontrolled proliferation of mature B lymphocytes. CLL is the most prevalent leukemia in Western countries. Its presentation can range from asymptomatic with the incidental finding of absolute lymphocytosis on a routine blood test, to symptomatic disease requiring immediate intervention. Prognosis of the disease is defined by the presence or absence of specific mutations such as TP53, chromosomal abnormalities such as del(17p), a type of IGHV mutational status, and elevation of B2M and LDH...
August 1, 2023: Hematology Reports
https://read.qxmd.com/read/37188944/how-i-managed-my-intense-burnout
#8
Kelly Korreck
No abstract text is available yet for this article.
May 15, 2023: Nature
https://read.qxmd.com/read/36807902/how-i-manage-mantle-cell-lymphoma-indolent-versus-aggressive-disease
#9
REVIEW
Matthew R Wilson, Aisling Barrett, Chan Yoon Cheah, Toby A Eyre
Mantle cell lymphoma (MCL) is a mature B-cell lymphoma with a variable clinical course and historically poor prognosis. Management is challenging in part due to the heterogeneity of the disease course, with indolent and aggressive subtypes now well recognised. Indolent MCL is often characterised by a leukaemic presentation, SOX11 negativity and low proliferation index (Ki-67). Aggressive MCL is characterised by rapid onset widespread lymphadenopathy, extra-nodal involvement, blastoid or pleomorphic histology and high Ki-67...
April 2023: British Journal of Haematology
https://read.qxmd.com/read/36786879/how-i-manage-anemia-related-to-myelofibrosis-and-its-treatment-regimens
#10
REVIEW
Srdan Verstovsek
Myelofibrosis (MF) is a myeloproliferative neoplasm characterized by mutations (most frequently in JAK2, CALR, or MPL), burdensome symptoms, splenomegaly, cytopenia, and shortened life expectancy. In addition to other clinical manifestations, patients with MF often develop anemia, which can either be directly related to MF pathogenesis or a result of MF treatment with Janus kinase (JAK) inhibitors, such as ruxolitinib and fedratinib. Although symptoms and clinical manifestations can be similar between the 2 anemia types, only MF-related anemia is prognostic of reduced survival...
April 2023: Annals of Hematology
https://read.qxmd.com/read/36574201/how-i-manage-transplant-ineligible-patients-with-myelodysplastic-neoplasms
#11
REVIEW
Carmelo Gurnari, Zhuoer Xie, Amer M Zeidan
Myelodysplastic neoplasms, formerly known as myelodysplastic syndromes (MDS), represent a group of clonal disorders characterized by a high degree of clinical and molecular heterogeneity, and an invariable tendency to progress to acute myeloid leukemia. MDS typically present in the elderly with cytopenias of different degrees and bone marrow dysplasia, the hallmarks of the disease. Allogeneic hematopoietic stem cell transplant is the sole curative approach to date. Nonetheless, given the disease's demographics, only a minority of patients can benefit from this procedure...
December 27, 2022: Clinical hematology international
https://read.qxmd.com/read/36108306/introduction-to-a-how-i-treat-series-on-management-of-high-risk-patients-following-allogeneic-transplant
#12
EDITORIAL
Robert Zeiser
No abstract text is available yet for this article.
January 5, 2023: Blood
https://read.qxmd.com/read/35977777/how-i-manage-hypertension-and-proteinuria-associated-with-vegf-inhibitor
#13
JOURNAL ARTICLE
Arash Rashidi, Rimda Wanchoo, Hassan Izzedine
No abstract text is available yet for this article.
January 1, 2023: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/35709903/how-i-manage-bacterial-prostatitis
#14
REVIEW
John C Lam, Raynell Lang, William Stokes
BACKGROUND: Bacterial prostatitis is a highly prevalent infection responsible for significant morbidity among men. The diagnosis and treatment for bacterial prostatitis remains complicated. The difficulty in diagnosis is in part owing to the paucity of high-quality evidence that guides a clinician's interpretation of patients' history, physical examination, and laboratory findings. Treatment is challenging because of the few antimicrobials capable of prostate penetration, growing antimicrobial resistance limiting effective treatment options, and the high risk of recurrence...
January 2023: Clinical Microbiology and Infection
https://read.qxmd.com/read/35405776/-how-i-manage-b-cell-lymphoma-patients-treated-with-cd19-specific-car-t-cell-throughout-whole-process-management
#15
JOURNAL ARTICLE
W B Qian, H Liu
No abstract text is available yet for this article.
March 14, 2022: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/35340664/how-i-manage-patients-with-chronic-myeloid-leukemia-cml-perspectives-from-clinical-practice
#16
JOURNAL ARTICLE
Guru Subramanian Guru Murthy
The management of chronic myeloid leukemia (CML) has remarkably changed in the last 20 years with the availability of tyrosine kinase inhibitors (TKI). Most patients with chronic phase CML now have a life expectancy like that of age matched controls. Understanding the practical aspects of choosing the appropriate TKI, monitoring response and side-effects are key to long term success. Currently, treatment cessation is also an option in patients achieving sustained deep molecular response. Novel agents are needed in patients with lack of response to TKI and in those with advanced disease...
2022: Blood and Lymphatic Cancer: Targets and Therapy
https://read.qxmd.com/read/34757117/how-i-manage-a-patient-with-mrsa-bacteraemia
#17
REVIEW
Joshua S Davis, Neta Petersiel, Steven Y C Tong
BACKGROUND: Staphylococcus aureus bloodstream infections are common and associated with a high mortality of 15-25%. Methicillin-resistant S. aureus (MRSA) bloodstream infection accounts for 10-40% of cases, and has an even higher mortality. Despite being the 'bread and butter' of clinical infectious diseases practice, robust evidence to guide optimal management is often lacking and there is wide variation in practice. OBJECTIVES: To provide a real-world example of a case of MRSA bacteraemia and the thought processes of the authors as key management decision points are reached...
February 2022: Clinical Microbiology and Infection
https://read.qxmd.com/read/34106909/how-i-manage-chronic-lymphocytic-leukemia
#18
JOURNAL ARTICLE
Nitin Jain
No abstract text is available yet for this article.
June 2021: Clinical Advances in Hematology & Oncology: H&O
https://read.qxmd.com/read/33657207/how-i-manage-acquired-pure-red-cell-aplasia-in-adults
#19
JOURNAL ARTICLE
Carmelo Gurnari, Jaroslaw P Maciejewski
Pure red cell aplasia (PRCA) is a rare hematological disorder with multiple etiologies. The multifaceted nature of this disease is emphasized by the variety of concomitant clinical features. Classic idiopathic presentation aside, prompt recognition of pathogenetic clues is important because of their diagnostic and therapeutic implications. As a consequence, treatment of PRCA is diverse and strictly dependent on the presented clinical scenario. Here, we propose a series of clinical vignettes that showcase instructive representative situations derived from our routine clinical practice...
April 15, 2021: Blood
https://read.qxmd.com/read/33434058/how-i-manage-pathophysiology-and-management-of-toxicity-of-chimeric-antigen-receptor-t-cell-therapies
#20
JOURNAL ARTICLE
Patrick M Reagan, Sattva S Neelapu
No abstract text is available yet for this article.
February 10, 2021: Journal of Clinical Oncology
keyword
keyword
164684
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.