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Methyl Cellulose Thermosensitive Hydrogel

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https://www.readbyqxmd.com/read/29953815/thermogelling-platform-for-baicalin-delivery-for-versatile-biomedical-applications
#1
Mohamed Haider, Mariame A Hassan, Iman S Ahmed, Rehab Shamma
Baicalin (BG) is a natural glycoside with several promising therapeutic and preventive applications. However, its pharmaceutical potential is compromised by its poor water solubility, complex oral absorption kinetics, and low bioavailability. In this work, BG was incorporated in a series of chitosan (Ch)/glycerophosphate (GP)-based thermosensitive hydrogel formulations to improve its water solubility and control its release profile. Molecular interactions between BG and GP were investigated using Fourier transform infrared spectroscopy (FT-IR), and the ability of GP to enhance the water solubility of BG was studied in different release media...
August 6, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/24299762/thermosensitive-methyl-cellulose-based-injectable-hydrogels-for-post-operation-anti-adhesion
#2
Yongli Zhang, Chunjuan Gao, Xiulan Li, Chen Xu, Yang Zhang, Zhiming Sun, Yu Liu, Jianping Gao
Thermosensitive methyl cellulose (MC)-based injectable hydrogels for post-operation anti-adhesion were prepared by integrating polyethylene glycol (PEG), carboxymethyl cellulose (CMC) and chitosan sulfate (CS-SO3) with MC sols. The viscosity of the MC-based sols depended on the sol composition, especially the amount of CMC. The gelation temperature of the sols was tuned by adjusting the concentrations of K(+) and other components to obtain an MC-based sol that transformed to a gel at body temperature. The composition of the sol also affected the gel strength...
January 30, 2014: Carbohydrate Polymers
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