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https://www.readbyqxmd.com/read/30322233/a-review-of-exposure-assessment-methods-for-epidemiological-studies-of-health-effects-related-to-industrially-contaminated-sites
#1
REVIEW
Gerard Hoek, Andrea Ranzi, Ilir Alimehmeti, Elena-Roxana Ardeleanu, Juan P Arrebola, Paula Ávila, Carla Candeias, Ann Colles, Gloria Cerasela Crișan, Sarah Dack, Zoltán Demeter, Lucia Fazzo, Tine Fierens, Benjamin Flückiger, Stephanie Gaengler, Otto Hänninen, Hedi Harzia, Rupert Hough, Barna Laszlo Iantovics, Olga-Ioanna Kalantzi, Spyros P Karakitsios, Konstantinos C Markis, Piedad Martin-Olmedo, Elena Nechita, Thomai Nicoli, Hans Orru, Roberto Pasetto, Francisco Miguel Pérez-Carrascosa, Diogo Pestana, Fernando Rocha, Dimosthenis A Sarigiannis, João Paulo Teixeira, Christos Tsadilas, Visa Tasic, Lorenzo Vaccari, Ivano Iavarone, Kees de Hoogh
BACKGROUND: this paper is based upon work from COST Action ICSHNet. Health risks related to living close to industrially contaminated sites (ICSs) are a public concern. Toxicology-based risk assessment of single contaminants is the main approach to assess health risks, but epidemiological studies which investigate the relationships between exposure and health directly in the affected population have contributed important evidence. Limitations in exposure assessment have substantially contributed to uncertainty about associations found in epidemiological studies...
September 2018: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/30322005/involving-the-microrna-targetome-in-esophageal-cancer-development-and-behavior
#2
REVIEW
Francisca Dias, Mariana Morais, Ana Luísa Teixeira, Rui Medeiros
Esophageal cancer (EC) is the eighth most common and sixth leading cause of cancer-related mortality in the world. Despite breakthroughs in EC diagnosis and treatment, patients with complete pathologic response after being submitted to chemoradiotherapy are still submitted to surgery, despite its high morbidity. Single-nucleotide polymorphisms (SNPs) in miRNA, miRNA-binding sites, and in its biogenesis pathway genes can alter miRNA expression patterns, thereby influencing cancer risk and prognosis. In this review, we systematized the information available regarding the impact of these miR-SNPs in EC development and prognosis...
October 12, 2018: Cancers
https://www.readbyqxmd.com/read/30320909/immune-endocrine-responses-and-physical-performance-of-master-athletes-during-the-sports-season
#3
Luciele Guerra Minuzzi, Luis Rama, Matheus Uba Chupel, Fátima Rosado, Gabriel Keine Kuga, Rafael Calais Gaspar, Vitor Rosetto Muñoz, José Rodrigo Pauli, Artur Paiva, Ana Maria Teixeira
The purpose of this study was to investigate the impact of a training season (approximately 7 months) on physiological and salivary immune-endocrine markers in master athletes. Nine male master athletes were evaluated at the beginning of the season (M1) and a week after the main official competition at the end of the sports season (M2). The controlled variables included Maximal oxygen consumption, anthropometric, physiological, and salivary immune-endocrine markers. Master athletes presented a reduced percentage of fat mass and increased lean body mass at the end of the season...
October 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30320170/colonic-gallstone-ileus-a-rare-case
#4
Cristina Teixeira, Ana Luisa Alves, Isabelle Cremers
No abstract text is available yet for this article.
September 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/30319253/fluorescence-properties-of-curcumin-loaded-nanoparticles-for-cell-tracking
#5
Bassam Felipe Mogharbel, Julio Cesar Francisco, Ana Carolina Irioda, Dilcele Silva Moreira Dziedzic, Priscila Elias Ferreira, Daiany de Souza, Carolina Maria Costa Oliveira de Souza, Nelson Bergonse Neto, Luiz Cesar Guarita-Souza, Celia Regina Cavichiolo Franco, Celso Vataru Nakamura, Vanessa Kaplum, Letícia Mazzarino, Elenara Lemos-Senna, Redouane Borsali, Paula A Soto, Patricia Setton-Avruj, Eltyeb Abdelwahid, Katherine Athayde Teixeira de Carvalho
Background: Posttransplant cell tracking, via stem cell labeling, is a crucial strategy for monitoring and maximizing benefits of cell-based therapies. The structures and functionalities of polysaccharides, proteins, and lipids allow their utilization in nanotechnology systems. Materials and methods: In the present study, we analyzed the potential benefit of curcumin-loaded nanoparticles (NPC) using Vero cells (in vitro) and NPC-labeled adipose-derived mesenchymal stem cells (NPC-ADMSCs) (in vivo) in myocardial infarction and sciatic nerve crush preclinical models...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30318391/arterial-stiffness-is-related-to-impaired-exercise-capacity-in-patients-with-coronary-artery-disease-and-history-of-myocardial-infarction
#6
Alberto Jorge Alves, Norton Luís Oliveira, Susana Lopes, Maria-Arantzazu Ruescas-Nicolau, Madalena Teixeira, José Oliveira, Fernando Ribeiro
BACKGROUND: Augmented arterial stiffness and reduced cardiorespiratory fitness are associated with increased morbidity and mortality from coronary artery disease (CAD). The relationship between exercise capacity and arterial stiffness is independent of known influencing variables in CAD. This study aimed to analyse the interaction between exercise capacity, arterial stiffness and early vascular ageing in patients with CAD. METHODS: This cross-sectional study included 96 CAD patients with myocardial infarction (55...
September 19, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/30317723/-pseudoaneurysm-of-the-popliteal-artery-associated-with-tibial-osteochondroma
#7
João Duarte Silva, Mariana Ferreira, Marina Neto, José Teixeira, Filipe Duarte
No abstract text is available yet for this article.
January 2018: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/30317718/manubrium-resection-and-reconstruction-for-mediastinal-tumor-a-case-report
#8
João Santos Silva, Carolina Torres, José Alberto Teixeira, Pedro Garcia, Paulo Calvinho
Primary mediastinal tumours with chest wall involvement represent technical challenges that may offer a survival benefit. Reconstruction with osteossynthesis material, bioprosthesis and muscle flaps is indicated to re-establish the excised component function. We report a case of a 30-year-old male with a primary mediastinal seminoma operated after chemotherapy with need for en bloc resection of the residual mass and manubrium with chest wall reconstruction. This type of surgery is rare and represents a technical challenge...
January 2018: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/30317709/-referral-and-coordination-of-healthcare-from-primary-care-to-angiology-and-vascular-surgery-a-center-s-experience
#9
João Rocha Neves, Marta Casal Moura, André Ferreira, Joel Sousa, Luís Gamas, Mário Vieira, Alcídia Pereira, Hélio Alves, José Teixeira
INTRODUCTION: Minimally invasive revascularization of the left anterior descending coronary artery has gained popularity. Recently, the emergence of new surgical instruments and the improvement of the technique, allowed its use by routine. Its use in Heart Team allows excellent results. Our aim is to present the results of patients undergoing this technique in our center. METHODS: Retrospective study of patients submitted to minimally invasive revascularization of the left anterior descending coronary artery at our center...
January 2018: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/30317702/-professor-doutor-ant%C3%A3-nio-braga-records-of-the-life-of-the-man-and-the-master
#10
EDITORIAL
José Fernando Teixeira
No abstract text is available yet for this article.
January 2018: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/30317556/atlantic-primates-a-dataset-of-communities-and-occurrences-of-primates-in-the-atlantic-forests-of-south-america
#11
Laurence Culot, Lucas Augusto Pereira, Ilaria Agostini, Marco Antônio Barreto de Almeida, Rafael Souza Cruz Alves, Izar Aximoff, Alex Bager, María Celia Baldovino, Thiago Ribas Bella, Júlio César Bicca-Marques, Caryne Braga, Carlos Rodrigo Brocardo, Ana Kellen Nogueira Campelo, Gustavo R Canale, Jader da Cruz Cardoso, Eduardo Carrano, Diogo Cavenague Casanova, Camila Righetto Cassano, Erika Castro, Jorge José Cherem, Adriano Garcia Chiarello, Braz Antonio Pereira Cosenza, Rodrigo Costa-Araújo, Nilmara Cristina da Silva, Mario S Di Bitetti, Aluane Silva Ferreira, Priscila Coutinho Ribas Ferreira, Marcos de S Fialho, Lisieux Franco Fuzessy, Guilherme Siniciato Terra Garbino, Francini de Oliveira Garcia, Cassiano A F R Gatto, Carla Cristina Gestich, Pablo Rodrigues Gonçalves, Nila Rássia Costa Gontijo, Maurício Eduardo Graipel, Carlos Eduardo Guidorizzi, Robson Odeli Espíndola Hack, Gabriela Pacheco Hass, Renato Richard Hilário, André Hirsch, Ingrid Holzmann, Daniel Henrique Homem, Hilton Entringer Júnior, Gilberto Sabino-Santos Júnior, Maria Cecília Martins Kierulff, Christoph Knogge, Fernando Lima, Elson Fernandes de Lima, Cristiana Saddy Martins, Adriana Almeida de Lima, Alexandre Martins, Waldney Pereira Martins, Fabiano R de Melo, Ricardo Melzew, João Marcelo Deliberador Miranda, Flávia Miranda, Andréia Magro Moraes, Tainah Cruz Moreira, Maria Santina de Castro Morini, Mariana B Nagy-Reis, Luciana Oklander, Leonardo de Carvalho Oliveira, Adriano Pereira Paglia, Anderson Pagoto, Marcelo Passamani, Fernando de Camargo Passos, Carlos A Peres, Michell Soares de Campos Perine, Míriam Plaza Pinto, Antonio Rossano Mendes Pontes, Marcio Port Carvalho, Bárbara Heliodora Soares do Prado, André Luis Regolin, Gabriela Cabral Rezende, Alessandro Rocha, Joedison Dos S Rocha, Raisa Reis de Paula Rodarte, Lilian Patrícia Sales, Edmilson Dos Santos, Paloma Marques Santos, Christine Steiner São Bernardo, Ricardo Sartorello, Leonardo La Serra, Eleonore Setz, Anne Sophie de Almeida E Silva, Leonardo Henrique da Silva, Pedro Bencke Ermel da Silva, Maurício Silveira, Rebecca L Smith, Sara Machado de Souza, Ana Carolina Srbek-Araujo, Leonardo Carreira Trevelin, Claudio Valladares Padua, Luciana Zago, Eduardo Marques, Stephen Francis Ferrari, Raone Beltrão-Mendes, Denison José Henz, Francys E da Veiga da Costa, Igor Kintopp Ribeiro, Lucas Lacerda Toth Quintilham, Marcos Dums, Pryscilla Moura Lombardi, Renata Twardowsky Ramalho Bonikowski, Stéfani Gabrieli Age, João Pedro Souza-Alves, Renata Chagas, Rogério Grassetto Teixeira da Cunha, Monica Mafra Valença-Montenegro, Gabriela Ludwig, Leandro Jerusalinsky, Gerson Buss, Renata Bocorny de Azevedo, Roberio Freire Filho, Felipe Bufalo, Louis Milhe, Mayara Mulato Dos Santos, Raíssa Sepulvida, Daniel da Silva Ferraz, Michel Barros Faria, Milton Cezar Ribeiro, Mauro Galetti
Primates play an important role in ecosystem functioning and offer critical insights into human evolution, biology, behavior, and emerging infectious diseases. There are 26 primate species in the Atlantic Forests of South America, 19 of them endemic. We compiled a dataset of 5,472 georeferenced locations of 26 native and 1 introduced primate species, as hybrids in the genera Callithrix and Alouatta. The dataset includes 700 primate communities, 8,121 single species occurrences and 714 estimates of primate population sizes, covering most natural forest types of the tropical and subtropical Atlantic Forest of Brazil, Paraguay and Argentina and some other biomes...
October 13, 2018: Ecology
https://www.readbyqxmd.com/read/30317129/the-inclusion-complex-of-carvacrol-and-%C3%AE-cyclodextrin-reduces-acute-skeletal-muscle-inflammation-and-nociception-in-rats
#12
Ana Carla A Souza, Fabíula F Abreu, Lúcio R L Diniz, Renata Grespan, Josimari M DeSantana, Lucindo J Quintans-Júnior, Paula P Menezes, Adriano A S Araújo, Cristiane B Correa, Simone A Teixeira, Marcelo N Muscará, Soraia K P Costa, Enilton A Camargo
BACKGROUND: Skeletal muscle inflammation is strongly associated with pain and may impair regeneration and functional recovery after injury. Since anti-inflammatory and antinociceptive effects have been described for the inclusion complex of carvacrol and β-cyclodextrin (βCD-carvacrol), this study investigated the effects of βCD-carvacrol in a model of acute skeletal muscle inflammation. METHODS: Muscle injury was induced in male Wistar rats by injection of 3% carrageenan in the gastrocnemius muscle...
October 11, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/30316960/high-intensity-respiratory-muscle-training-improves-strength-and-dyspnea-after-stroke-a-double-blind-randomized-trial
#13
Kênia Kiefer Parreiras de Menezes, Lucas Rodrigues Nascimento, Louise Ada, Patrick Roberto Avelino, Janaine Cunha Polese, Maria Tereza Mota Alvarenga, Mariana Hoffman Barbosa, Luci Fuscaldi Teixeira-Salmela
OBJECTIVE: To examine whether high-intensity home-based respiratory muscle training, ie, with higher loads, delivered more frequently and for longer duration, than previously applied, would increase the strength and endurance of the respiratory muscles, reduce dyspnea and respiratory complications, and improve walking capacity after stroke. DESIGN: Randomized trial with concealed allocation, blinded participants and assessors, and intention-to-treat analysis. SETTING: Community patients...
October 11, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/30316882/variable-expressivity-and-novel-pten-mutations-in-cowden-syndrome
#14
Renato Assis Machado, Lívia Maris Ribeiro Paranaíba, Luciane Martins, Mário Rodrigues Melo-Filho, Thays Teixeira de Souza, Bruna Lavinas Sayed Picciani, Geraldo Oliveira Silva-Junior, Marília Heffer Cantisano, Breno Amaral Rocha, Fábio Ramoa Pires, Ricardo D Coletta
Cowden syndrome (CS) is a phosphatase and tensin homolog gene (PTEN)-associated condition characterized by multiple mucocutaneous hamartomas and an increased risk of malignancies. We reported an isolated case and another of several individuals in one family affected by CS. The isolated case showed typical features, including fibrocystic breast disease, benign thyroid nodules, and multiple papillomatous lesions in the face and oral cavity, and the cause was a novel nonsense mutation-guanine (G) to thymine (T) transition at position 940 (c...
September 7, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/30316593/effects-of-pegbovigrastim-administration-on-periparturient-diseases-milk-production-and-reproductive-performance-of-holstein-cows
#15
M Zinicola, H Korzec, A G V Teixeira, E K Ganda, L Bringhenti, A C C H Tomazi, R O Gilbert, R C Bicalho
The aim of this study was to evaluate the effects of treating Holstein cows with pegbovigrastim on periparturient diseases, milk production, and reproductive performance while exploring the mode of action of an immunomodulatory protein. Cows were randomly allocated to 1 of 2 treatments, untreated control (CTR, n = 423) and pegbovigrastim (PEG, n = 417). At 7 d from the anticipated calving date (d -7), cows allocated to PEG received a subcutaneous injection of 15 mg of pegylated recombinant bovine granulocyte colony stimulating factor (pegbovigrastim injection, Imrestor, Elanco Animal Health, Greenfield, IN)...
October 10, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/30314373/coagulotoxicity-of-bothrops-lancehead-pit-vipers-venoms-from-brazil-differential-biochemistry-and-antivenom-efficacy-resulting-from-prey-driven-venom-variation
#16
Leijiane F Sousa, Christina N Zdenek, James S Dobson, Bianca Op den Brouw, Francisco Coimbra, Amber Gillett, Tiago H M Del-Rei, Hipócrates de M Chalkidis, Sávio Sant'Anna, Marisa M Teixeira-da-Rocha, Kathleen Grego, Silvia R Travaglia Cardoso, Ana M Moura da Silva, Bryan G Fry
Lancehead pit-vipers ( Bothrops genus) are an extremely diverse and medically important group responsible for the greatest number of snakebite envenomations and deaths in South America. Bothrops atrox (common lancehead), responsible for majority of snakebites and related deaths within the Brazilian Amazon, is a highly adaptable and widely distributed species, whose venom variability has been related to several factors, including geographical distribution and habitat type. This study examined venoms from four B...
October 11, 2018: Toxins
https://www.readbyqxmd.com/read/30313665/geographic-variation-and-taxonomy-of-red-tailed-gymnophthalmus-squamata-gymnophthalmidae-from-amazonian-savannas
#17
Renato Sousa Recoder, Francisco Dal Vechio, Sergio Marques-Souza, Mauro Jr Teixeira, Maiume Silva-da-Silva, Alfredo P Santos-Jr, SÍria Ribeiro, Cesar Barrio-Amorós, Miguel Trefaut Rodrigues
Gymnophthalmus represents a challenging group for systematics of microteiid lizards. Due to scarcity of exemplars and molecular data, the taxonomy of the genus has been unstable, and six of its eight species are considered part of a poorly-delimited complex of unisexual and bisexual species. Unnamed populations of red-tailed Gymnophthalmus from savanna enclaves in Amazon, similar to G. vanzoi but with differences in color pattern, have been noted in the literature. Here, we used molecular and morphological data to test the taxonomic status of the Central Amazonian red-tailed Gymnophthalmus (G...
October 8, 2018: Zootaxa
https://www.readbyqxmd.com/read/30313519/a-new-four-pored-amphisbaena-linnaeus-1758-amphisbaenia-amphisbaenidae-from-brazilian-amazon
#18
Elaine C S Oliveira, Wilian Vaz-Silva, Alfredo P Santos-Jr, Roberta Graboski, Mauro Jr Teixeira, Francisco Dal Vechio, SÍria Ribeiro
A new species of Amphisbaena is described from the Brazilian Amazon, within the area impacted by the Teles Pires hydroelectric power plant, Jacareacanga municipality, State of Pará. Amphisbaena hoogmoedi sp. nov. can be diagnosed from its congeners by the following combination of characters: snout convex in profile view, sligthly compressed not keeled; pectoral scales arranged in regular annuli; conspicuous autotomic site between 7th-8th caudal annuli; 247-252 dorsal half-annuli; 27 caudal annuli; tail length 9...
May 18, 2018: Zootaxa
https://www.readbyqxmd.com/read/30312879/potent-immunosuppressive-activity-of-a-phosphodiesterase-4-inhibitor-n-acylhydrazone-in-models-of-lipopolysaccharide-induced-shock-and-delayed-type-hypersensitivity-reaction
#19
Elisalva Teixeira Guimarães, Tatiana Barbosa Dos Santos, Dahara Keyse Carvalho Silva, Cássio Santana Meira, Diogo Rodrigo Magalhães Moreira, Tiago Fernandes da Silva, Didier Salmon, Eliezer J Barreiro, Milena Botelho Pereira Soares
Immunosuppressive drugs are widely used for the treatment of immune-mediated diseases and inflammation, but the toxicity and side effects of the available immunosuppressors make the search of new agents of great relevance. Here, we evaluated the immunomodulatory activity of an N-acylhydrazone derivative, (E)-N'-(3,4-dimethoxybenzylidene)-4-methoxybenzohydrazide (LASSBio-1386), a phosphodiesterase-4 (PDE-4) inhibitor. LASSBio-1386 inhibited lymphocyte activation in a concentration-dependent fashion, decreasing lymphoproliferation and IFN-γ and IL-2 production stimulated by anti-CD3/CD28 mAbs or concanavalin A (Con A) and inducing cell-cycle arrest in the G0/G1 phase...
October 9, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/30312457/height-and-body-mass-index-as-modifiers-of-breast-cancer-risk-in-brca1-2-mutation-carriers-a-mendelian-randomization-study
#20
Frank Qian, Shengfeng Wang, Jonathan Mitchell, Lesley McGuffog, Daniel Barrowdale, Goska Leslie, Jan C Oosterwijk, Wendy K Chung, D Gareth Evans, Christoph Engel, Karin Kast, Cora M Aalfs, Muriel A Adank, Julian Adlard, Bjarni A Agnarsson, Kristiina Aittomäki, Elisa Alducci, Irene L Andrulis, Banu K Arun, Margreet G E M Ausems, Jacopo Azzollini, Emmanuelle Barouk-Simonet, Julian Barwell, Muriel Belotti, Javier Benitez, Andreas Berger, Ake Borg, Angela R Bradbury, Joan Brunet, Saundra S Buys, Trinidad Caldes, Maria A Caligo, Ian Campbell, Sandrine M Caputo, Jocelyne Chiquette, Kathleen B M Claes, J Margriet Collée, Fergus J Couch, Isabelle Coupier, Mary B Daly, Rosemarie Davidson, Orland Diez, Susan M Domchek, Alan Donaldson, Cecilia M Dorfling, Ros Eeles, Lidia Feliubadaló, Lenka Foretova, Jeffrey Fowler, Eitan Friedman, Debra Frost, Patricia A Ganz, Judy Garber, Vanesa Garcia-Barberan, Gord Glendon, Andrew K Godwin, Encarna B Gómez Garcia, Jacek Gronwald, Eric Hahnen, Ute Hamann, Alex Henderson, Carolyn B Hendricks, John L Hopper, Peter J Hulick, Evgeny N Imyanitov, Claudine Isaacs, Louise Izatt, Ángel Izquierdo, Anna Jakubowska, Katarzyna Kaczmarek, Eunyoung Kang, Beth Y Karlan, Carolien M Kets, Sung-Won Kim, Zisun Kim, Ava Kwong, Yael Laitman, Christine Lasset, Min Hyuk Lee, Jong Won Lee, Jihyoun Lee, Jenny Lester, Fabienne Lesueur, Jennifer T Loud, Jan Lubinski, Noura Mebirouk, Hanne E J Meijers-Heijboer, Alfons Meindl, Austin Miller, Marco Montagna, Thea M Mooij, Patrick J Morrison, Emmanuelle Mouret-Fourme, Katherine L Nathanson, Susan L Neuhausen, Heli Nevanlinna, Dieter Niederacher, Finn C Nielsen, Robert L Nussbaum, Kenneth Offit, Edith Olah, Kai-Ren Ong, Laura Ottini, Sue K Park, Paolo Peterlongo, Georg Pfeiler, Catherine M Phelan, Bruce Poppe, Nisha Pradhan, Paolo Radice, Susan J Ramus, Johanna Rantala, Mark Robson, Gustavo C Rodriguez, Rita K Schmutzler, Christina G Hutten Selkirk, Payal D Shah, Jacques Simard, Christian F Singer, Johanna Sokolowska, Dominique Stoppa-Lyonnet, Christian Sutter, Yen Yen Tan, R Manuel Teixeira, Soo H Teo, Mary Beth Terry, Thomassen Mads, Tischkowitz Marc, E Toland Amanda, M Tucker Katherine, Tung Nadine, Christi J van Asperen, Klaartje van Engelen, Elizabeth J van Rensburg, Shan Wang-Gohrke, Barbara Wappenschmidt, Jeffrey N Weitzel, Drakoulis Yannoukakos, Mark H Greene, Matti A Rookus, Douglas F Easton, Georgia Chenevix-Trench, Antonis C Antoniou, David E Goldgar, Olufunmilayo I Olopade, Timothy R Rebbeck, Dezheng Huo
Background: BRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear. Methods: We used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer...
October 12, 2018: Journal of the National Cancer Institute
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