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Tiago Costa Goes, Thiago Henrique Almeida Souza, Murilo Marchioro, Flavia Teixeira-Silva
The neural substrate of anxiety response (state anxiety) to a threatening situation is well defined. However, a lot less is known about brain structures implicated in the individual's predisposition to anxiety (trait anxiety). Scientific evidences lead us to suppose that the medial prefrontal cortex (mPFC) is involved in both trait and state anxiety. Thus, the aim of this study was to investigate the involvement of mPFC in trait anxiety and to further evaluate its participation in state anxiety. Sixty six adult, Wistar, male rats were first tested in the free-exploratory paradigm (FEP) and were categorized according to their levels of trait anxiety (high, medium and low)...
August 15, 2018: Brain Research Bulletin
Gustavo Roberto Thomé, Vitor Antunes Oliveira, Maria Rosa Chitolina Schetinger, Rogério Aquino Saraiva, Diego Souza, Oscar Endrigo Dorneles Rodrigues, João Batista Teixeira Rocha, Rafael Porto Ineu, Maria Ester Pereira
The present study evaluated the neuroprotective effects of one selenium-containing AZT derivative compound (S1073) in memory and learning impairment caused by Intracerebroventricular-streptozotocin (ICV-STZ). ICV-STZ in mice causes impairment of energy metabolism with oxidative damage and cholinergic dysfunction, and provides a relevant model for sporadic dementia of Alzheimer's type (AD). Acetylcolinesterase (AChE), Catalase (CAT), dichlorofluorescein oxidation (DCFH), TBARS and thiol content were measured...
August 15, 2018: Chemico-biological Interactions
Elena Y Demireva, Deepika Suri, Emanuela Morelli, Darshini Mahadevia, Nao Chuhma, Catia M Teixeira, Annette Ziolkowski, Marc Hersh, James Fifer, Sneha Bagchi, Alexei Chemiakine, Holly Moore, Jay A Gingrich, Peter Balsam, Stephen Rayport, Mark S Ansorge
Serotonin (5-HT) selective reuptake inhibitors (SSRIs) are widely used in the treatment of depression and anxiety disorders, but responsiveness is uncertain and side effects often lead to discontinuation. Side effect profiles suggest that SSRIs reduce dopaminergic (DAergic) activity, but specific mechanistic insight is missing. Here we show in mice that SSRIs impair motor function by acting on 5-HT2C receptors in the substantia nigra pars reticulata (SNr), which in turn inhibits nigra pars compacta (SNc) DAergic neurons...
August 17, 2018: Molecular Psychiatry
Valeria Lis Le Gall, Guilherme Marcondes Klafke, Tatiana Teixeira Torres
The cattle tick Rhipicephalus microplus is one of the most important ectoparasites with great sanitary and economic impact for cattle rearing worldwide. Ivermectin is commonly used to control tick populations, but its use over the last 30 years has led to the development of resistant populations of R. microplus, and a concomitant loss of efficacy. In this context, we aimed to determine the metabolic mechanisms that contribute to ivermectin resistance in a resistant strain of this species. We performed lethal time bioassays with inhibitors of detoxifying enzymes and xenobiotic transporters (four detoxification pathways) using two strains of ticks: a susceptible strain, Mozo, and a resistant strain, Juarez...
August 17, 2018: Scientific Reports
Larissa Tavares Aguiar, Sylvie Nadeau, Raquel Rodrigues Britto, Luci Fuscaldi Teixeira-Salmela, Júlia Caetano Martins, Christina Danielli Coelho de Morais Faria
BACKGROUND: Post-stroke physical inactivity is explained by several factors related to the stroke, which have been suggested as the causes and consequences of functional declines and health problems. Therefore, it is important to increase physical activity levels and reduce the time spent in low-energy expenditure activities after a stroke. Since the maintenance of cardiorespiratory fitness is a significant predictor of physical activity levels post-stroke, it may be important to investigate whether aerobic training is effective in increasing physical activity levels and reducing the time spent in low-energy expenditure activities in this population...
August 17, 2018: Trials
Jason C Ong, Donna Arand, Michael Schmitz, Kelly Baron, Richard Blackburn, Michael A Grandner, Kenneth L Lichstein, Sara Nowakowski, Celso Teixeira, Karlyn Boling, Spencer C Dawson, Kathryn Hansen
No abstract text is available yet for this article.
August 17, 2018: Behavioral Sleep Medicine
Olga Pereira, Alexandra Teixeira, Belém Sampaio-Marques, Isabel Castro, Henrique Girão, Paula Ludovico
Acute myeloid leukaemia (AML) comprises a heterogeneous group of hematologic neoplasms characterized by diverse combinations of genetic, phenotypic and clinical features representing a major challenge for the development of targeted therapies. Metabolic reprogramming, mainly driven by deregulation of the nutrient-sensing pathways as AMPK, mTOR and PI3K/AKT, has been associated with cancer cells, including AML cells, survival and proliferation. Nevertheless, the role of these metabolic adaptations on the AML pathogenesis is still controversial...
August 17, 2018: Journal of Cellular and Molecular Medicine
Stephanie M Teixeira-Poit, Ariana Napier, Christine Carr, Jessica Williams, Paul Pulliam
OBJECTIVES: This study explores the extent to which directors of organizations perceive that (a) older adults are aware of and interested in using services, and (b) their employees are aware of complementary services in the community and are willing to coordinate care or refer older adults to these services. METHOD: We conducted 41 qualitative semistructured interviews with organizational directors who provide services to older adults. RESULTS: Directors perceived that not only older adults but also some providers were unaware of services in the community...
August 17, 2018: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
J H Azambuja, N E Gelsleichter, L R Beckenkamp, I C Iser, M C Fernandes, F Figueiró, A M O Battastini, J N Scholl, F H de Oliveira, R M Spanevello, Jean Sévigny, M R Wink, M A Stefani, H F Teixeira, Elizandra Braganhol
Glioblastoma is the worst and most common primary brain tumor. Here, we demonstrated the role of CD73, an enzyme responsible for adenosine (ADO) production, in glioblastoma progression. ADO increased glioma cell viability via A1 receptor sensitization. CD73 downregulation decreased glioma cell migration and invasion by reducing metalloproteinase-2 and vimentin expression and reduced cell proliferation by 40%, which was related to necrosis and sub-G1 phase blockage of cell cycle. Those effects also involved the stimulation of Akt/NF-kB pathways...
August 16, 2018: Molecular Neurobiology
Rena C Moon, Andre F Teixeira, Lyz Bezerra, Helga Cristina Almeida Wahnon Alhinho, Josemberg Campos, Luiz Gustavo de Quadros, Artagnan Menezes Barbosa de Amorim, Manoel Galvao Neto, Muhammad A Jawad
BACKGROUND: Complications after bariatric procedures including leaks and strictures can be difficult to treat. Endoscopic treatment may be preferable due to its less invasiveness. The aim of this study is to describe usage of stents in treating complications after bariatric procedures, along with its indications, methods, and outcome. MATERIAL AND METHODS: A total of 87 patients underwent endoscopic stenting after a bariatric procedure from January 1, 2013, and December 31, 2016, in four bariatric centers...
August 16, 2018: Obesity Surgery
Tamara Daiane de Souza, Alisson Carraro Borges, Antonio Teixeira de Matos, Renato Welmer Veloso, Amanda Fernandes Braga
This work aimed to study the kinetics of arsenic absorption by Eichhornia crassipes and Lemna valdiviana under pre-established conditions of pH phosphate and nitrate in the nutrient solution. Additional aims were to evaluate the conversion kinetics between As(III) and As(V), and the effect of arsenic concentrations on development of the species. The plants were cultivated in nutrient solutions containing different arsenic concentrations: 0, 0.56, 0.89 and 1.38 mg L-1 for the water-hyacinth, and 0, 0.13, 0...
October 2018: Chemosphere
Lívia Clemente Motta-Teixeira, Aline Vilar Machado-Nils, Daniella Sabino Battagello, Giovanne Baroni Diniz, Jéssica Andrade-Silva, Sinésio Silva-Junior, Raphael Afonso Matos, Fernanda Gaspar do Amaral, Gilberto Fernando Xavier, Jackson Cioni Bittencourt, Russel J Reiter, Paul Jonh Lucassen, Aniko Korosi, José Cipolla-Neto
Maternal melatonin provides photoperiodic information to the fetus and thus influences the regulation and timing of the offspring's internal rhythms and preparation for extra-uterine development. There is clinical evidence that melatonin deprivation of both mother and fetus during pregnancy, and of the neonate during lactation, results in negative long-term health outcomes. As a consequence, we hypothesized that the absence of maternal pineal melatonin might determine abnormal brain programming in the offspring, which would lead to long-lasting implications for behavior and brain function...
August 13, 2018: Hormones and Behavior
Benedito Jamilson Araújo Pereira, Antônio Nogueira de Almeida, Wellingson Silva Paiva, Paulo Henrique Pires de Aguiar, Manoel Jacobsen Teixeira, Suely Kazue Nagahashi Marie
Review the data published on the subject to create a more comprehensive natural history of intraventricular meningiomas (IVMs). A Medline search up to March 2018 using "intraventricular meningioma" returned 98 papers. As a first selection step, we adopted the following inclusion criteria: series and case reports about IVMs, as well as papers written in other languages, but abstracts written in English were evaluated. Six hundred eighty-one tumors were evaluated from 98 papers. The majority of the tumors were located in the lateral ventricles (602-88...
August 15, 2018: Neurosurgical Review
Leonardo do Prado Lima, Carla Jorge Machado, João Bernardo Sancio Rocha Rodrigues, Leonardo de Souza Vasconcellos, Eduardo Paulino Junior, Paula Vieira Teixeira Vidigal, Vivian Resende
Background and Aim: The epithelial cell adhesion molecule (EpCAM) has been proposed as a marker for cancer stem cells in human hepatocellular carcinoma (HCC) as well as in the development of novel target therapies. This study aimed to investigate the immunohistochemical expression of EpCAM and alpha-fetoprotein (AFP) in HCC patients and their association with clinicopathological characteristics. Methods: This study included Child-Pugh A HCC patients undergoing curative surgical resection...
2018: Canadian Journal of Gastroenterology & Hepatology
Carla Cristi Avila, Simon Ngao Mule, Livia Rosa-Fernandes, Rosa Viner, María Julia Barisón, André Guillherme Costa-Martins, Gilberto Santos de Oliveira, Marta Maria Geraldes Teixeira, Claudio Romero Farias Marinho, Ariel Mariano Silber, Giuseppe Palmisano
Trypanosoma cruzi , the etiologic agent of Chagas disease, cycles through different life stages characterized by defined molecular traits associated with the proliferative or differentiation state. In particular, T. cruzi epimastigotes are the replicative forms that colonize the intestine of the Triatomine insect vector before entering the stationary phase that is crucial for differentiation into metacyclic trypomastigotes, which are the infective forms of mammalian hosts. The transition from proliferative exponential phase to quiescent stationary phase represents an important step that recapitulates the early molecular events of metacyclogenesis, opening new possibilities for understanding this process...
August 15, 2018: Genes
Filipe Martins Santos, Gabriel Carvalho de Macedo, Wanessa Teixeira Gomes Barreto, Luiz Gustavo Rodrigues Oliveira-Santos, Carolina Martins Garcia, Guilherme de Miranda Mourão, Grasiela Edith de Oliveira Porfírio, Elizangela Domenis Marino, Marcos Rogério André, Lívia Perles, Carina Elisei de Oliveira, Gisele Braziliano de Andrade, Ana Maria Jansen, Heitor Miraglia Herrera
The occurrence of Trypanosoma spp. in wild carnivore populations has been intensively investigated during the last decades. However, the impact of these parasites on the health of free-living infected animals has been largely neglected. The Pantanal biome is the world's largest seasonal wetland, harboring a great diversity of species and habitats. This includes 174 species of mammals, of which 20 belong to the order Carnivora. The present study aimed to investigate the effect of Trypanosoma evansi and Trypanosoma cruzi infections and coinfections on the health of the most abundant carnivores in the Pantanal: coati (Nasua nasua), crab-eating fox (Cerdocyon thous), and ocelot (Leopardus pardalis)...
2018: PloS One
Mayara Kelly Moura Ferreira, Sabrina de Souza Gurgel, Francisca Elisângela Teixeira Lima, Maria Vera Lúcia Moreira Leitão Cardoso, Viviane Martins da Silva
OBJECTIVE: to identify existing instruments in the scientific literature about the care of pressure injuries in pediatric and hebiatric patients. METHOD: an integrative review that selected 32 articles from the PubMed/Medline, LILACS, Scopus and CINAHL databases using the descriptors pressure ulcer, decubitus ulcer, pediatrics, adolescent and protocols and their equivalent terms in Portuguese and Spanish. Inclusion criteria: research articles in full, in Portuguese, English or Spanish without any temporal cut-off...
August 9, 2018: Revista Latino-americana de Enfermagem
Marcela Prado Silva Parizi, Arlen Mabel Lastre Acosta, Hamilton Mitsugu Ishiki, Renata Calciolari Rossi, Renata Cristina Mafra, Antonio Carlos Silva Costa Teixeira
The synthetic hormone sodium levothyroxine (LTX) is one of the most prescribed drugs in the world and the most effective in hypothyroidism treatment. The presence of LTX in the environment has become a matter of major concern due to the widespread use of this hormone and by the fact that it is only partially removed in conventional water and sewage treatment plants. However, information regarding the photochemical fate of this hormone in environmental or engineered systems is scarce in the literature. In this work, the sunlight-driven direct and indirect LTX degradation was investigated by determining the photolysis quantum yield, ΦLTX  = 3...
August 14, 2018: Environmental Science and Pollution Research International
C Teixeira, C Martins, E Dantas, D Trabulo, J Mangualde, R Freire, A L Alves, I Cremers, A P Oliveira
INTRODUCTION AND AIMS: Interval colorectal cancer (iCRC) can occur due to missed lesions or to a newly developed lesion. The present study aimed to assess the iCRC rate and its characteristics in our population and find possible explanations. MATERIALS AND METHODS: A retrospective study was conducted on patients with colorectal cancer (CRC) diagnosed between January 2011 and January 2015 at our department. Demographics, endoscopic data, and tumor characteristics (location, histology, staging) were collected...
August 11, 2018: Revista de Gastroenterología de México
Maria Luiza Guimarães de Oliveira, Luciana Caricati Veiga-Castelli, Letícia Marcorin, Guilherme Debortoli, Alison Luis Eburneo Pereira, Nádia Carolina de Aguiar Fracasso, Guilherme do Valle Silva, Andréia S Souza, Juliana Doblas Massaro, Aguinaldo Luiz Simões, Audrey Sabbagh, Eduardo Antônio Donadi, Erick C Castelli, Celso Teixeira Mendes-Junior
Human leukocyte antigen-G (HLA-G) is a nonclassical Major Histocompatibility Complex (MHC) molecule with immunomodulatory function and restricted tissue expression. The genetic diversity of HLA-G has been extensively studied in several populations, however, the segment located upstream -1406 has not yet been evaluated. We characterized the nucleotide variation and haplotype structure of an extended distal region (-2635), all exons and the 3'UTR segment of HLA-G by next-generation sequencing (NGS) in a sample of 335 Brazilian individuals...
August 11, 2018: Human Immunology
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