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CCN1 calcium signal

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https://www.readbyqxmd.com/read/25822023/ccn1-induces-hepatic-ductular-reaction-through-integrin-%C3%AE-v%C3%AE-%C3%A2-mediated-activation-of-nf-%C3%AE%C2%BAb
#1
Ki-Hyun Kim, Chih-Chiun Chen, Gianfranco Alpini, Lester F Lau
Liver cholestatic diseases, which stem from diverse etiologies, result in liver toxicity and fibrosis and may progress to cirrhosis and liver failure. We show that CCN1 (also known as CYR61), a matricellular protein that dampens and resolves liver fibrosis, also mediates cholangiocyte proliferation and ductular reaction, which are repair responses to cholestatic injury. In cholangiocytes, CCN1 activated NF-κB through integrin αvβ5/αvβ3, leading to Jag1 expression, JAG1/NOTCH signaling, and cholangiocyte proliferation...
May 2015: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/14606958/ccn3-and-calcium-signaling
#2
Alain Lombet, Nathalie Planque, Anne-Marie Bleau, Chang Long Li, Bernard Perbal
The CCN family of genes consists presently of six members in human (CCN1-6) also known as Cyr61 (Cystein rich 61), CTGF (Connective Tissue Growth Factor), NOV (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). Results obtained over the past decade have indicated that CCN proteins are matricellular proteins, which are involved in the regulation of various cellular functions, such as proliferation, differentiation, survival, adhesion and migration. The CCN proteins have recently emerged as regulatory factors involved in both internal and external cell signaling...
August 15, 2003: Cell Communication and Signaling: CCS
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