keyword
https://read.qxmd.com/read/38535871/plasma-%C3%AE-aminobutyric-acid-gaba-concentrations-in-lactating-holstein-cows-during-thermoneutral-and-heat-stress-conditions-and-their-relationships-with-circulating-glucose-insulin-and-progesterone-levels
#1
JOURNAL ARTICLE
Alicia G Arneson, Jacob W Stewart, MaryKate H Byrd, George A Perry, Michelle L Rhoads
Heat-stressed lactating dairy cattle exhibit unique metabolic symptoms, many of which are undoubtedly involved in heat-induced subfertility. Because of its known systemic effects, we hypothesized that γ-aminobutyric acid (GABA) participates in the regulation of insulin and progesterone during heat stress. Multiparous lactating Holstein cows (n = 6) were studied during four experimental periods: (1) thermoneutral (TN; d 1-5), (2) TN + hyperinsulinemic-hypoglycemic clamp (d 6-10), (3) heat stress (HS; d 16-20), and (4) HS + euglycemic clamp (d 21-25)...
March 21, 2024: Veterinary Sciences
https://read.qxmd.com/read/38527122/comment-on-umapathysivam-et-al-euglycemic-ketoacidosis-in-two-patients-without-diabetes-after-introduction-of-sodium-glucose-cotransporter-2-inhibitor-for-heart-failure-with-reduced-ejection-fraction-diabetes-care-2024-47-140-143
#2
JOURNAL ARTICLE
https://read.qxmd.com/read/38527115/comment-on-umapathysivam-et-al-euglycemic-ketoacidosis-in-two-patients-without-diabetes-after-introduction-of-sodium-glucose-cotransporter-2-inhibitor-for-heart-failure-with-reduced-ejection-fraction-diabetes-care-2024-47-140-143
#3
JOURNAL ARTICLE
Foussard Ninon, Larroumet Alice, Barbet-Massin Marie-Amélie, Blanco Laurence, Mohammedi Kamel, Couffinhal Thierry, Fawaz Sami, Pucheu Yann, Rigalleau Vincent
No abstract text is available yet for this article.
April 1, 2024: Diabetes Care
https://read.qxmd.com/read/38515279/clinical-pharmacology-of-gp40321-insulin-glulisine-biosimilar-pharmacokinetic-and-pharmacodynamic-comparability-in-a-hyperinsulinemic-euglycemic-clamp-procedure
#4
JOURNAL ARTICLE
Ekaterina Koksharova, Roman Drai, Sergei Noskov, Artem Dorotenko, Ekaterina Protsenko, Kseniia Radaeva, Anna Arefeva, Maria Gefen, Gagik Galstyan, Igor Makarenko
The aim of the study was to compare the pharmacokinetics (PK) and pharmacodynamics (PD) of T-glu (GP40321, test drug), and reference insulin glulisine in a hyperinsulinemic-euglycemic clamp procedure. During this study, 34 healthy male volunteers underwent the hyperinsulinemic-euglycemic clamp procedure following subcutaneous 0.3 U/kg injection of T-glu or reference insulin glulisine in a randomized, double-blind, crossover study. Plasma glucose levels were monitored every 5 minutes for 8 hours...
March 21, 2024: Clinical Pharmacology in Drug Development
https://read.qxmd.com/read/38513367/high-intensity-interval-training-combining-rowing-and-cycling-improves-but-does-not-restore-beta-cell-function-in-type-2-diabetes
#5
JOURNAL ARTICLE
Maria Houborg Petersen, Jacob Volmer Stidsen, Martin Eisemann de Almeida, Emil Kleis Wentorf, Kurt Jensen, Niels Ørtenblad, Kurt Højlund
AIMS: We investigated whether a high-intensity interval training (HIIT)-protocol could restore beta-cell function in type 2 diabetes compared with sedentary obese and lean individuals. MATERIALS AND METHODS: In patients with type 2 diabetes, and age-matched, glucose-tolerant obese and lean controls, we examined the effect of 8-weeks of supervised HIIT combining rowing and cycling on the acute (first-phase) and second-phase insulin responses, beta-cell function adjusted for insulin sensitivity (disposition index) and serum free fatty acid (FFA) levels using the Botnia clamp (1-h IVGTT followed by 3-h hyperinsulinemic-euglycemic clamp)...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38502790/metabolic-fluxes-in-the-renal-cortex-are-dysregulated-in-vivo-in-response-to-high-fat-diet
#6
JOURNAL ARTICLE
Clinton M Hasenour, Deveena R Banerjee, Jamey D Young
Diabetes and obesity are risk factors for kidney disease. While renal glucose production increases in diabetes, recent data suggest that gluconeogenic and oxidative capacity decline in kidney disease. Thus, metabolic dysregulation caused by diet-induced insulin resistance may sensitize the kidney for a loss in function. Here we examined how diet-induced insulin resistance disrupts mitochondrial metabolic fluxes in the renal cortex in vivo. C57Bl/6J mice were rendered insulin resistant through high-fat (HF) feeding; anaplerotic, cataplerotic, and oxidative metabolic fluxes in the cortex were quantified through 13C-isotope tracing during a hyperinsulinemic-euglycemic clamp...
March 19, 2024: Diabetes
https://read.qxmd.com/read/38500825/quantifying-the-effect-of-nutritional-interventions-on-metabolic-resilience-using-personalized-computational-models
#7
JOURNAL ARTICLE
Shauna D O'Donovan, Milena Rundle, E Louise Thomas, Jimmy D Bell, Gary Frost, Doris M Jacobs, Anne Wanders, Ryan de Vries, Edwin C M Mariman, Marleen A van Baak, Luc Sterkman, Max Nieuwdorp, Albert K Groen, Ilja C W Arts, Natal A W van Riel, Lydia A Afman
The manifestation of metabolic deteriorations that accompany overweight and obesity can differ greatly between individuals, giving rise to a highly heterogeneous population. This inter-individual variation can impede both the provision and assessment of nutritional interventions as multiple aspects of metabolic health should be considered at once. Here, we apply the Mixed Meal Model, a physiology-based computational model, to characterize an individual's metabolic health in silico. A population of 342 personalized models were generated using data for individuals with overweight and obesity from three independent intervention studies, demonstrating a strong relationship between the model-derived metric of insulin resistance (ρ = 0...
April 19, 2024: IScience
https://read.qxmd.com/read/38491968/impact-of-insulin-induced-relative-hypoglycemia-on-vascular-insulin-sensitivity-and-central-hemodynamics-in-prediabetes
#8
JOURNAL ARTICLE
Daniel J Battillo, Mary-Margaret E Remchak, Ankit M Shah, Steven K Malin
CONTEXT: Relative hypoglycemia (RH) is linked to sympathetic responses that can alter vascular function in individuals with type 2 diabetes. However, less is known about the role of RH on hemodynamics or metabolic insulin sensitivity in prediabetes. OBJECTIVE: Determine if RH alters peripheral endothelial function or central hemodynamics to a greater extent in those with prediabetes (PD) versus normoglycemia (NG). METHODS: Seventy adults with obesity were classified using ADA criteria as PD (n=34 (28F); HbA1c=6...
March 16, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38487831/the-13c-glucose-breath-test-accurately-identifies-insulin-resistance-in-people-with-type-1-diabetes
#9
JOURNAL ARTICLE
Jonathan Mertens, Laurence Roosens, Rie Braspenning, Joeri Vandebeeck, Sven Francque, Christophe De Block
OBJECTIVE: This study investigated whether the delta-over-baseline of exhaled 13CO2 (Δ13CO2), generated from a 13C glucose breath test (13C-GBT), measured insulin resistance (IR) in people with type 1 diabetes, using the hyperinsulinemic-euglycemic clamp (HEC) as reference method. Secondary objective was to compare the 13C-GBT with the estimated glucose disposal rate (eGDR). METHODS: A 40 mU/m2/min HEC and two separate 13C-GBTs (euglycemic with insulin bolus and hyperglycemic without bolus) were consecutively performed in 44 adults with type 1 diabetes with varying body compositions...
March 15, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38479917/glucose-turnover-at-whole-body-and-skeletal-muscle-level-in-response-to-parenteral-nutrition-in-male-patients-with-alcoholic-liver-cirrhosis
#10
JOURNAL ARTICLE
Beckey Trinh, Anders Rasmussen Rinnov, Ulrik Winning Iepsen, Gregers Winding Munch, Kamilla Munch Winding, Carsten Lauridsen, Lise Lotte Gluud, Gerrit van Hall, Helga Ellingsgaard
BACKGROUND & AIMS: Cirrhosis is associated with insulin resistance and impaired glucose tolerance, which may be caused by impairments at different tissue levels (liver, skeletal muscle, and/or beta cell). METHODS: Here, glucose kinetics at whole-body and skeletal muscle level in patients with cirrhosis (Child-Pugh A and B) were studied during parenteral nutrition using the isotope dilution technique and arteriovenous balance approach across the leg. As opposed to the euglycemic hyperinsulinemic clamp or glucose tolerance tests applied in previous studies, this approach provides a nutrient composition more similar to a normal meal while circumventing any possible portal-systemic shunting, impaired hepatic uptake and incretin effect...
April 2024: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38479367/the-modulation-of-euglycemic-endocrine-and-exocrine-pancreatic-secretions-in-iron-deficiency
#11
JOURNAL ARTICLE
Mohammad A Bani-Ahmad, Noor E Abu Tayyem
OBJECTIVES: The contribution of pancreatic secretions in iron metabolism is elucidated. Still, the clinical outcomes of iron deficiency on pancreatic function are debatable. This study aimed to investigate the modulation of euglycemic endocrine and exocrine pancreatic excretions in response to variations in iron availability. SUBJECTS AND METHODS: A total of one hundred and seventy (N=170) adult subjects with variable extents of serum iron levels were included. Serum levels of insulin, glucagon, insulin-to-glucagon ratio (IGR), and amylase were determined...
March 13, 2024: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/38461133/hemoadsorption-therapy-for-calcium-channel-blocker-overdose-a-case-report
#12
JOURNAL ARTICLE
Shahed Omar, Pano Parris, Chloe Rose Gurke
BACKGROUND: Modern resin hemoadsorption/hemoperfusion for calcium channel blocker overdose is yet to be reported. The characteristics of calcium channel blockers make them unamenable to removal by hemodiafiltration or charcoal hemoperfusion; however, elimination, using styrene bead adsorption in an ex vivo model, has been demonstrated. Its clinical use is described. CASE REPORT: A man in his 20s was admitted with shock into the Intensive Care Unit (ICU) after an overdose of amlodipine and risperidone...
December 9, 2023: Journal of Emergency Medicine
https://read.qxmd.com/read/38455692/can-euglycemic-diabetic-ketoacidosis-caused-by-sglt2-inhibitors-be-avoided-in-covid-19-and-other-acute-infections
#13
JOURNAL ARTICLE
Georgios Pilianidis, Georgia Papanastasiou, Pinelopi Tikoudi, Andreas Themistocleous, Georgios Farmakis, Konstantinos Dolianitis
INTRODUCTION: We present a case of anion gap euglycemic diabetic ketoacidosis (EuDKA) in a patient with COVID-19 infection. Patients with diabetes mellitus are at increased risk of severe illness, and hyperglycaemia is associated with higher morbidity and mortality in patients infected with COVID-19. CASE DESCRIPTION: A 76-year-old male with diabetes mellitus treated with SGLT2 inhibitor tested positive for COVID-19 infection on day 3 after his admission. In the emergency room he had a high anion gap metabolic acidosis and a blood glucose of 248 mg/dl...
2024: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/38450653/diet-quality-and-blood-pressure-among-pregnant-women-with-overweight-or-obesity-a-secondary-analysis-of-two-randomized-controlled-trials
#14
JOURNAL ARTICLE
Sorcha Lynch, Sarah Louise Killeen, Eileen O'Brien, Kate Mullane, Emma Hokey, Grace Mealy, Fionnuala M McAuliffe
INTRODUCTION: Maternal obesity is a significant risk factor for hypertensive disorders of pregnancy. High diet quality may protect against this, yet data regarding the relationship between diet quality and blood pressure among pregnant women with raised body mass index (BMI) is limited. MATERIAL AND METHODS: This is a secondary analysis (n = 543) of women with BMI ≥25 kg/m2 from two randomized controlled trials; PEARS (Pregnancy Exercise and nutrition Research Study with smartphone application support) and ROLO (Randomized cOntrol trial of LOw glycemic index diet to prevent macrosomia in euglycemic women)...
March 7, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38428527/pros-of-inpatient-sglt-2-inhibitor-use
#15
REVIEW
Karina Romo, Roma Gianchandani
SGLT-2 inhibitors are widely used for diabetes management especially since their effects go beyond glucose control. More recently their indications and usage has expanded to heart failure and renal dysfunction therapy in patients both with and without diabetes. Beneficial effects, especially for heart failure readmission accrue very early in their treatment trajectory and this has promoted their use in the hospital setting. Data on their safety and efficacy for inpatient use is accumulating but has lagged behind the outpatient data for their use...
February 28, 2024: Endocrine Practice
https://read.qxmd.com/read/38417551/the-effect-of-high-fat-diet-on-intramyocellular-lipid-content-in-healthy-adults-a-systematic-review-meta-analysis-and-meta-regression
#16
REVIEW
Jasem Alqallaf, Samuel T Orange, Jamie Matu, Alex Griffiths, Kelsie Johnson, Antonis Stavropoulos-Kalinoglou, Adrian Holliday, Oliver Wilson
Fatty acids are stored within muscle as intramyocellular lipids (IMCL). Some, but not all, studies indicate that following a high fat diet (HFD), IMCL may accumulate and affect insulin sensitivity. This systematic review and meta-analysis aimed to quantify the effects of a HFD on IMCL. It also explored the potential modifying effects of HFD fat content and duration, IMCL measurement technique, physical activity status, and the associations of IMCL with insulin sensitivity. Five databases were systematically searched for studies that examined the effect of ≥3 days of HFD (>35% daily energy intake from fat) on IMCL content in healthy individuals...
February 26, 2024: Journal of Nutrition
https://read.qxmd.com/read/38416072/sedentary-time-associates-detrimentally-and-physical-activity-beneficially-with-metabolic-flexibility-in-adults-with-metabolic-syndrome
#17
JOURNAL ARTICLE
Taru Garthwaite, Tanja Sjöros, Saara Laine, Mikko Koivumäki, Henri Vähä-Ypyä, Tiina Verho, Jooa Norha, Petri Kallio, Maria Saarenhovi, Eliisa Löyttyniemi, Harri Sievänen, Noora Houttu, Kirsi Laitinen, Kari K Kalliokoski, Tommi Vasankari, Juhani Knuuti, Ilkka Heinonen
Metabolic flexibility (MetFlex) describes the ability to respond and adapt to changes in metabolic demand and substrate availability. The relationship between physical (in)activity and MetFlex is unclear. This study aimed to determine whether sedentary time, physical activity (PA), and cardiorespiratory fitness associate with MetFlex. Sedentary time, standing, and PA were measured with accelerometers for four weeks in 64 sedentary adults with metabolic syndrome (37 women, 27 men; 58.3 [SD 6.8] years). Fitness (VO2 max [mL·kg-1 ·min-1 ]) was measured with graded maximal cycle ergometry...
February 28, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38414717/a-case-of-type-2-diabetes-mellitus-with-lung-cancer-suffered-from-euglycemic-diabetic-ketosis-accompanied-by-adrenal-insufficiency-after-immune-checkpoint-inhibitors
#18
Saeko Shibasaki, Chisei Noda, Akihisa Imagawa, Sadaki Sakane
A 74-year-old patient with type 2 diabetes mellitus received basal-bolus insulin, insulin secretagogues, and sodium glucose transporter 2 (SGLT2) inhibitors. After immune checkpoint inhibitor treatment for lung cancer, he suffered from depressed consciousness with a urinary ketone body (3+). When all hypoglycemic treatments were discontinued, his serum blood glucose remained at 121 mg/dL. He was diagnosed with euglycemic diabetic ketosis. Endocrine loading tests revealed isolated adrenocorticotropic hormone (ACTH) deficiency as an immune-related adverse event...
2024: Case Reports in Endocrinology
https://read.qxmd.com/read/38414363/sex-differences-in-insulin-regulation-of-skeletal-muscle-glycogen-synthase-and-changes-during-weight-loss-and-exercise-in-adults
#19
JOURNAL ARTICLE
Alice S Ryan, Guoyan Li, Shawna McMillin, Heidi K Ortmeyer
OBJECTIVE: The authors sought to understand sex differences in muscle metabolism in 73 older men and women. METHODS: Body composition, VO2 max, and insulin sensitivity (M) by 3-hour hyperinsulinemic-euglycemic clamp with vastus lateralis muscle biopsies were measured. RESULTS: Women had lower body weight, VO2 max, and fat-free mass than men. Men had lower M, lower change (insulin minus basal) in muscle glycogen synthase (GS) activity, and lower change in AKT protein expression than women...
February 27, 2024: Obesity
https://read.qxmd.com/read/38405702/microvascular-insulin-resistance-associates-with-enhanced-muscle-glucose-disposal-in-cd36-deficiency
#20
Cyndya A Shibao, Vivek S Peche, Ian M Williams, Dmitri Samovski, Terri A Pietka, Naji N Abumrad, Eric Gamazon, Ira Goldberg, David Wasserman, Nada A Abumrad
Dysfunction of endothelial insulin delivery to muscle associates with insulin resistance. CD36, a fatty acid transporter and modulator of insulin signaling is abundant in endothelial cells, especially in capillaries. Humans with inherited 50% reduction in CD36 expression have endothelial dysfunction but whether it is associated with insulin resistance is unclear. Using hyperinsulinemic/euglycemic clamps in Cd36-/- and wildtype mice, and in 50% CD36 deficient humans and matched controls we found that Cd36-/- mice have enhanced systemic glucose disposal despite unaltered transendothelial insulin transfer and reductions in microvascular perfusion and blood vessel compliance...
February 18, 2024: medRxiv
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