Sven Krengel, Imke Stark, Christian Geuchen, Bettina Knoppe, Gabriele Scheel, Peter Schlenke, Andreas Gebert, Lutz Wünsch, Jürgen Brinckmann, Michael Tronnier
In vivo, melanocytes bind to laminin (LM) molecules of the basement membrane (BM) via the integrins alpha3beta1 and alpha6beta1, and they adhere to neighbouring keratinocytes via E-cadherin. Only few studies have addressed the impact of ultraviolet (UV) light on the interaction of melanocytes with their microenvironment. In this report, we examined the influence of UVB irradiation on the expression of the most important melanocyte-adhesion molecules (E-, N-cadherin, alpha2-, alpha3-, alpha5-, alpha6-, alphaV-, beta1-, beta3-integrins and ICAM-1) in vitro by flow cytometry...
June 2005: Experimental Dermatology