Jason Y Zhang, Jason Xiao, Bingqing Xie, Hugo Barba, Michael Boachie-Mensah, Rohan N Shah, Urooba Nadeem, Melanie Spedale, Nicholas Dylla, Huaiying Lin, Ashley M Sidebottom, Mark D'Souza, Betty Theriault, Dinanath Sulakhe, Eugene B Chang, Dimitra Skondra
PURPOSE: Emerging data indicate that metformin may prevent the development of age-related macular degeneration (AMD). Whereas the underlying mechanisms of metformin's anti-aging properties remain undetermined, one proposed avenue is the gut microbiome. Using the laser-induced choroidal neovascularization (CNV) model, we investigate the effects of oral metformin on CNV, retinal pigment epithelium (RPE)/choroid transcriptome, and gut microbiota. METHODS: Specific pathogen free (SPF) male mice were treated via daily oral gavage of metformin 300 mg/kg or vehicle...
December 1, 2023: Investigative Ophthalmology & Visual Science