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https://www.readbyqxmd.com/read/30513598/blood%C3%A2-brain-barrier-lymphatic-clearance-and-recovery-ariadne-s-thread-in-labyrinths-of-hypotheses
#1
REVIEW
Oxana Semyachkina-Glushkovskaya, Dmitry Postnov, Jürgen Kurths
The peripheral lymphatic system plays a crucial role in the recovery mechanisms after many pathological changes, such as infection, trauma, vascular, or metabolic diseases. The lymphatic clearance of different tissues from waste products, viruses, bacteria, and toxic proteins significantly contributes to the correspondent recovery processes. However, understanding of the cerebral lymphatic functions is a challenging problem. The exploration of mechanisms of lymphatic communication with brain fluids as well as the role of the lymphatic system in brain drainage, clearance, and recovery is still in its infancy...
November 30, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30511290/subgroups-of-high-cost-medicare-advantage-patients-an-observational-study
#2
Brian W Powers, Jiali Yan, Jingsan Zhu, Kristin A Linn, Sachin H Jain, Jennifer L Kowalski, Amol S Navathe
BACKGROUND: There is a growing focus on improving the quality and value of health care delivery for high-cost patients. Compared to fee-for-service Medicare, less is known about the clinical composition of high-cost Medicare Advantage populations. OBJECTIVE: To describe a high-cost Medicare Advantage population and identify clinically and operationally significant subgroups of patients. DESIGN: We used a density-based clustering algorithm to group high-cost patients (top 10% of spending) according to 161 distinct demographic, clinical, and claims-based variables...
December 3, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/30507857/the-effectiveness-of-junctional-tourniquets-a-systematic-review-and-meta-analysis
#3
Shane Smith, John White, Kerollos Nashat Wanis, Andrew Beckett, Vivian C McAlister, Richard Hilsden
BACKGROUND: Junctional tourniquets have been incorporated into tactical combat casualty care for junctional vascular trauma. They apply external compression to stop blood flow in the groin and axilla. OBJECTIVES: The primary outcome was effectiveness in achieving arterial occlusion. Secondary outcomes included time to application and pain scores. DATA SOURCES: Medline and EMBASE databases were searched. STUDY APPRAISAL AND SYNTHESIS METHODS: A random effects meta-analysis was conducted to estimate the average effectiveness and time to effective application for each device...
November 30, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30504343/breadth-of-complications-of-long-term-oral-anticoagulant-care
#4
REVIEW
Walter Ageno, Marco Donadini
The majority of patients with venous thromboembolism (VTE) have a considerable long-term risk of recurrence and may require extended duration of anticoagulant treatment after the initial 3 to 6 months. The decision to extend treatment is based not only on the individual risk of recurrence, but should also consider the potential complications associated with anticoagulation, taking into account that anticoagulant drugs are among the drugs most frequently associated with hospital admission due to adverse drug reactions...
November 30, 2018: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/30500659/readmissions-after-firearm-injury-requiring-vascular-repair
#5
Jeffrey J Siracuse, Alik Farber, Thea James, Thomas W Cheng, Yi Zuo, Jeffrey A Kalish, Douglas W Jones, Bindu Kalesan
INTRODUCTION: Firearm injuries can be morbid and potentially have high resource utilization. Historically, trauma and vascular surgery patients are at higher risk for readmissions. Our goal was to assess the risk for readmission among patients undergoing vascular repair after a firearm injury. METHODS: The National Readmission Database was queried from 2011-2014. All firearm injuries with or without vascular repair were analyzed. Multivariable analysis was conducted to assess the effect of concurrent vascular repair on readmissions at 30, 90, and 180 days...
November 27, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30500644/the-epidemiology-of-micro-arteriovenous-fistulas-in-the-lower-legs
#6
Fukashi Serizawa, Miyako Tanaka, Takuya Shimizu, Daijirou Akamatsu, Masato Ohara, Hitoshi Goto, Takashi Kamei
OBJECTIVE: Patients presenting with edema, skin redness, pain, and itching in their lower legs are common and encountered often in daily practice. However, although commonly recognized diseases, such as deep venous thrombosis (DVT), stasis dermatitis due to varicose veins, lymphedema, and cellulitis, are diagnosed correctly in most cases, micro-arteriovenous fistulas (AVFs) may often be overlooked due to low awareness and rarity. This study was carried out to evaluate the prevalence of micro-AVF in patients presenting with foot skin symptoms...
November 27, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30497228/nationwide-analysis-of-hospital-to-hospital-transfer-in-patients-with-aneurysmal-subarachnoid-hemorrhage-requiring-aneurysm-repair
#7
(no author information available yet)
OBJECTIVEAneurysmal subarachnoid hemorrhage (aSAH) has devastating consequences. The association between higher institutional volumes and improved outcomes for aSAH patients has been studied extensively. However, the literature exploring patterns of transfer in this context is sparse. Expansion of the endovascular workforce has raised concerns about the decentralization of care, reduced institutional volumes, and worsened patient outcomes. In this paper, the authors explored various patient and hospital factors associated with the transfer of aSAH patients by using a nationally representative database...
October 1, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/30496904/three-cases-of-large-diameter-true-brachial-and-axillary-artery-aneurysm-and-a-review-of-the-literature
#8
Dilsad Amanvermez Senarslan, Funda Yildirim, Omer Tetik
Aneurysms of the upper extremity mostly originate from trauma, mycotic lesions, thoracic outlet syndrome, previous arteriovenous fistulae and atherosclerosis. True aneurysms of the brachial and axillary artery are encountered rarely. They can be diagnosed by simple physical examination as a pulsatile mass. However, most of these aneurysms remain asymptomatic until a complication occurs. The primary complication seen with the axillary or brachial artery is embolization. We report three large diameter true brachial artery aneurysms extending to the axillary zone...
November 26, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30496865/the-chondrocyte-cell-proliferation-of-a-chitosan-silk-fibroin-egg-shell-membrane-hydrogels
#9
Terin Adali, Rasime Kalkan, Leila Karimizarandi
Articular cartilage is a poorly cellularized, non-vascularized connective tissue that undergoes alterations due to trauma and osteoarthritis. Tissue engineering strategies involving the combination of cells, biomaterials and bioactive agents have been of interest notably for the repair of damaged articular cartilage. The aim of this study was to design Chitosan/Silk Fibroin/Egg Shell Membrane (CHI/SF/ESM) hydrogels and analyse the cell proliferation activity of human chondrocyte cells. The FTIR spectrophotometer, XRD analysis, ICP-MS, SEM analysis, swelling kinetics and biodegradation tests with protease enzyme, and antibacterial activity test with Escherichia coli, Candida albicans have been used for characterization of hydrogels...
November 26, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30488252/contrast-enhanced-ultrasound-in-delayed-splenic-vascular-injury-and-active-extravasation-diagnosis
#10
Corrado Tagliati, Giulio Argalia, Gabriele Polonara, Andrea Giovagnoni, Gian Marco Giuseppetti
INTRODUCTION: We describe the use of contrast-enhanced ultrasound (CEUS) in the diagnosis of delayed splenic vascular injury (DSVI) and active extravasation (DAE) during spleen injury follow-up. CEUS might be used instead of contrast-enhanced computed tomography (CECT) during spleen injury follow-up in order to reduce radiation exposure. OBJECTIVE: Assess diagnostic comparability between CEUS and CECT in the evaluation of DSVI and DAE during spleen injury follow-up...
November 28, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/30478818/a-case-report-of-scrotal-rejuvenation-laser-treatment-of-angiokeratomas-of-the-scrotum
#11
Philip R Cohen
Scrotal rejuvenation encompasses not only the functional quality but also the aesthetic appearance of the scrotum. It includes medical therapy and procedural interventions to improve scrotal conditions that require morphologic restoration and/or aesthetic alteration. Rejuvenation of the scrotum may be appropriate for aging-related and non-aging-related changes concerning the hair (alopecia and hypertrichosis), the morphology (laxity and wrinkles), and/or the vascularity (angiokeratoma) of the scrotum. Angiokeratomas-typically small, asymptomatic, purple papules-may occur on the scrotum...
November 26, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/30476614/trends-and-outcomes-of-pediatric-vascular-injuries-in-the-united-states-an-analysis-of-the-national-trauma-data-bank
#12
Mohammad H Eslami, Zein M Saadeddin, Denis V Rybin, Efthymios D Avgerinos, Pegeen W Eslami, Jeffrey J Siracuse, Alik Farber
BACKGROUND: According to the Center for Disease Control and Prevention, trauma is the leading cause of death in children >1 year in the United States (US). Although vascular injuries occur in only 0.6-1% of pediatric trauma patients, they are a major mortality contributor. This study aims to examine epidemiology and outcomes after pediatric vascular injuries (Ped VIs) in the US. METHODS: National Trauma Data Bank (2002-2012) was queried to identify children (0-16) with PedVIs...
November 23, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30473029/survival-trends-after-inferior-vena-cava-and-aortic-injuries-in-the-united-states
#13
Bernardino C Branco, Tashinga Musonza, Michael A Long, Jayer Chung, Samual R Todd, Matthew J Wall, Joseph L Mills, Ramyar Gilani
OBJECTIVE: Recent studies have demonstrated an increase in trauma mortality relative to mortality from cancer and heart diseases in the United States. Major vascular injuries such as to the inferior vena cava (IVC) and aortic injuries remain responsible for a significant proportion of early trauma deaths in modern trauma care. The purpose of this study was to explore patterns in epidemiology and mortality after IVC and aortic injuries in the United States. METHODS: A 13-year analysis of the National Trauma Databank (2002-2014) was performed to extract all patients who sustained IVC, abdominal aortic, or thoracic aortic injuries...
December 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/30471758/the-aberrant-epigenetic-modifications-in-the-pathogenesis-of-psoriasis
#14
Ming Zhao, Qianjin Lu
Psoriasis is a chronic and recurrent inflammatory skin disease that is characterized by abnormal keratinocyte proliferation, vascular hyperplasia, and infiltration of inflammatory cells into the dermis and epidermis. It is generally accepted that the central pathogenesis of psoriasis is dysfunction of T lymphocytes, which are affected by the complex interplay between genetic and environmental factors, including trauma, infections, stress, drugs, smoking, and alcohol consumption (Nestle et al., 2009). The environmentally induced epigenetic changes, including DNA methylation, histone modification, and microRNAs, have been shown to be involved in the pathogenesis of this disease (Zhang et al...
December 2018: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/30466637/imaging-of-temporal-bone-trauma-a-clinicoradiologic-perspective
#15
REVIEW
Joshua E Lantos, Kristen Leeman, Elizabeth K Weidman, Kathryn E Dean, Tiffany Peng, Aaron N Pearlman
Imaging plays an important role in the evaluation of temporal bone trauma. Certain imaging findings can significantly change patient management or change surgical approach. Precise knowledge of clinical or surgical management can guide the review of imaging to detect these key findings. This article reviews the clinical and imaging findings as well as management of complications from temporal bone trauma, including hearing loss, vertigo, perilymphatic fistula, cerebrospinal fluid leak, facial nerve injury and vascular injury...
February 2019: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/30461567/mesenchymal-stem-cell-derived-extracellular-vesicles-attenuate-pulmonary-vascular-permeability-and-lung-injury-induced-by-hemorrhagic-shock-and-trauma-erratum
#16
(no author information available yet)
No abstract text is available yet for this article.
December 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/30461447/efficacy-of-axillary-versus-infraclavicular-brachial-plexus-block-in-preventing-tourniquet-pain-a-randomised-trial
#17
David Brenner, Gabriella Iohom, Padraig Mahon, George Shorten
BACKGROUND: Axillary and infraclavicular brachial plexus blocks are commonly used for upper limb surgery. Clinicians require information on the relative benefits of each to make a rational selection for specific patients and procedures. OBJECTIVES: The main objective of the study was to compare axillary and infraclavicular brachial plexus block in terms of the incidence and severity of tourniquet pain. DESIGN: Single blinded, randomised trial...
November 19, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/30458745/clinical-implications-of-fracture-associated-vascular-damage-in-extremity-and-pelvic-trauma
#18
F Gilbert, C Schneemann, C J Scholz, R Kickuth, R H Meffert, R Wildenauer, U Lorenz, R Kellersmann, A Busch
BACKGROUND: Vascular damage in polytrauma patients is associated with high mortality and morbidity. Therefore, specific clinical implications of vascular damage with fractures in major trauma patients are reassessed. METHODS: This comprehensive nine-year retrospective single center cohort study analyzed demography, laboratory, treatment and outcome data from 3689 patients, 64 patients with fracture-associated vascular injuries were identified and were compared to a control group...
November 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/30458128/sirt1-activation-promotes-angiogenesis-in-diabetic-wounds-by-protecting-endothelial-cells-against-oxidative-stress
#19
Xiaoqiang Li, Gaofeng Wu, Fu Han, Kejia Wang, Xiaozhi Bai, Yanhui Jia, Zhenzhen Li, Weixia Cai, Wanfu Zhang, Linlin Su, Dahai Hu
OBJECTIVE: Chronic wounds are a devastating complication of diabetes and can lead to amputations or even death. Current medical therapies are insufficient to accelerate its repair. The objective of this study was to explore the role of Sirtuin1 (SIRT1) in diabetic wounds. METHODS AND MATERIALS: Perilesional skin tissue samples from diabetic ulcers and normoglycemic trauma wounds were used to detect SIRT1 expression and oxidative stress levels. In a diabetic mouse model, SIRT1 was pharmacologically activated to attenuate angiogenesis and accelerate wound closure...
November 17, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/30453789/giant-lymphatic-malformations-in-lower-extremity-in-an-adult-a-case-report
#20
Bommie Florence Seo, Kyo Joon Kang, Hyuk Joon Choi, Kyung Jin Seo, Sung-No Jung, Jongweon Shin
Lymphatic malformations are benign vascular malformations rarely seen in adults. There have been only around 100 cases reported in the literature, most of them located in the head and neck area. The etiology is poorly understood but trauma, infection, or tumors have been suggested as possible causes. We present an unusual case of lymphatic malformations in the lower extremity of a 56-year-old male patient after minor trauma. The masses were asymptomatic but progressively enlarged for a period of 2 months, developing into a mass with a 21-cm-long axis in computed tomography images...
November 19, 2018: International Journal of Lower Extremity Wounds
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