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Roberta Balansin Rigon, Sabine Kaessmeyer, Christopher Wolff, Christian Hausmann, Nan Zhang, Michaela Sochorová, Andrej Kováčik, Rainer Haag, Kateřina Vávrová, Martina Ulrich, Monika Schäfer-Korting, Christian Zoschke
Aging depicts one of the major challenges in pharmacology owing to its complexity and heterogeneity. Thereby, advanced glycated end-products modify extracellular matrix proteins, but the consequences on the skin barrier function remain heavily understudied. Herein, we utilized transmission electron microscopy for the ultrastructural analysis of ribose-induced glycated reconstructed human skin (RHS). Molecular and functional insights substantiated the ultrastructural characterization and proved the relevance of glycated RHS beyond skin aging...
November 8, 2018: International Journal of Molecular Sciences
Li Zhao, Shuangshuang Dong, Yunli Zhao, Huimin Shao, Natalia Krasteva, Qiuli Wu, Dayong Wang
In nematode Caenorhabditis elegans, epidermal RNA interference (RNAi) knockdown of bli-1 encoding a cuticular collagen caused the toxicity induction of GO-PEG (PEG surface modified graphene oxide). In this study, we further found that epidermal RNAi knockdown of bli-1 increased expression of a microRNA let-7, and let-7 mutation suppressed the susceptibility of bli-1(RNAi) nematodes to GO-PEG toxicity. let-7 regulated the toxicity induction of GO-PEG by suppressing expression and function of its direct targets (HBL-1 and LIN-41)...
November 6, 2018: Ecotoxicology and Environmental Safety
Amr Maged, Abdelfattah A Abdelkhalek, Azza A Mahmoud, Salwa Salah, Mohamed M Ammar, Mahmoud M Ghorab
In this study we explored the role of rosuvastatin calcium in skin regeneration as statins play important role in the field of tissue engineering. Chitosan hydrochloride was crosslinked with different weight ratios of collagen, β-glycerolphosphate and carboxymethyl cellulose to produce scaffolds by lyophilization technique. Subsequently, the fabricated scaffolds were examined for their morphology, water absorption capacity, water retention, friability and in-vitro drug release as well as in-vivo studies. The results revealed porous 3-D structured scaffolds with maximum water absorption values-ranging between 396 and 2993%...
November 6, 2018: European Journal of Pharmaceutical Sciences
Xiao Jiang, Fan Wu, Yuan Xu, Jian-Xin Yan, Yin-Di Wu, Sheng-Hong Li, Xuan Liao, Jun-Xian Liang, Ze-Hua Li, Hong-Wei Liu
BACKGROUND: Recent evidence suggests that angiotensin II (Ang II) plays a role in cutaneous wound healing. Mesenchymal stem cells (MSCs) are known as a rich source of cells that re-establish healed skin. However, the potential impact of Ang II on MSC differentiation into keratinocytes is still unknown. OBJECTIVE: The present study was conducted to explore the effect of Ang II on differentiation of bone marrow-derived MSCs (BM-MSCs) into keratinocytes. METHODS: BM-MSCs were isolated from rat bone marrow and cultured...
November 9, 2018: Experimental Dermatology
Elisa Aquilanti, Julie Miller, Sandro Santagata, Daniel P Cahill, Priscilla K Brastianos
Gliomas are the most common primary malignant brain tumor in adults. The traditional classification of gliomas has been based on histologic features and tumor grade. The advent of sophisticated molecular diagnostic techniques has led to a deeper understanding of genomic drivers implicated in gliomagenesis, some of which have important prognostic implications. These advances have led to an extensive revision of the World Health Organization classification of diffuse gliomas to include molecular markers such as isocitrate dehydrogenase mutation, 1p/19q codeletion, and histone mutations as integral components of brain tumor classification...
November 9, 2018: Neuro-oncology
Sandi Shen, Guihua Wu, Gaofang Xiao, Richang Du, Ningdong Hu, Xu Xia, Haibo Zhou
The aim of this study was to evaluate the correlation between lymphovascular invasion (LVI) and tumor size, histological grade, and the expression statuses of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2), Ki67, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), E-cadherin, and P53 in invasive breast cancer, then establish a prediction model of LVI based on the associated clinicopathological factors.A total of 392 patients with primary invasive breast cancers were enrolled, and their paraffin-embedded tissues were manufactured into the tissue microarray...
October 2018: Medicine (Baltimore)
Jing-Min Dong, Hong-Xia Wang, Xiao-Fei Zhong, Kun Xu, Jia Bian, Yan Feng, Liang Chen, Lin Zhang, Xia Wang, De-Jing Ma, Bin Wang
This study aimed to analyze the relationship between pathologic complete response (pCR) and changes in background parenchymal enhancement (BPE) levels in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer and who received neoadjuvant chemotherapy (NAC).The pre- and post-NAC magnetic resonance imaging results of 51 patients with confirmed unilateral HER2-positive breast cancer were retrospectively analyzed by 2 experienced radiologists. Pre- and post-NAC of contralateral BPE levels were classified into 4 categories (1 = minimal, 2 = mild, 3 = moderate, and 4 = marked)...
October 2018: Medicine (Baltimore)
Tiantian Yang, Peng Xiao, JinMing Zhang, Ruonan Jia, Haq Nawaz, Zhangyan Chen, Jun Zhang
Excessive radicals and UV irradiation can trigger oxidative and physiological stresses, which cause tissue aging, human disease, food spoilage, and material degradation. In this study, a multifunctional cellulose ester containing hindered phenol groups, cellulose 3,5-di-tert-butyl-4-hydroxybenzoate (CBH), with free-radical scavenging and UV-resistant activities was synthesized and used as functional material. The obtained CBHs can effectively scavenge reactive nitrogen free-radicals and hydroxyl free-radicals in both solid and solution states...
November 9, 2018: ACS Applied Materials & Interfaces
Bing Li, Lan Ma, Chi Zhang, Zhixuan Zhou, Hua Yuan, Hongbing Jiang, Yongchu Pan, Qian Tan
BACKGROUND: The genetic etiology of nonsyndromic cleft lip with or without cleft palate (NSCL/P) has not been fully clarified to date. Epidermal growth factor receptor (EGFR) was reportedly involved in its biological establishment and regulation of cell migration during the embryonic stage. METHODS: We selected a super pathway of endocytic trafficking of EGFR and investigated the associations of single-nucleotide polymorphisms (SNPs) in the super pathway with the risk of NSCL/P by analyzing our published genome-wide association study (GWAS) data from 504 NSCL/P individuals and 455 controls...
November 8, 2018: Molecular Genetics & Genomic Medicine
Daniel C Beachler, Cynthia de Luise, Ruihua Yin, Kelsey Gangemi, Philip T Cochetti, Stephan Lanes
PURPOSE: Claims databases offer large populations for research, but lack clinical details. We aimed to develop predictive models to identify estrogen receptor positive (ER+) and human epidermal growth factor negative (HER2-) early breast cancer (ESBC) and advanced stage breast cancer (ASBC) in a claims database. METHODS: Female breast cancer cases in Anthem's Cancer Care Quality Program served as the gold standard validation sample. Predictive models were developed from clinical knowledge and empirically from claims data using logistic and lasso regression...
November 9, 2018: Pharmacoepidemiology and Drug Safety
Eva Santamaría, Carlos M Rodríguez-Ortigosa, Iker Uriarte, Maria U Latasa, Raquel Urtasun, Gloria Alvarez-Sola, Marina Bárcena-Varela, Leticia Colyn, Sara Arcelus, Maddalen Jiménez, Kathleen Deutschmann, Ana Peleteiro-Vigil, Julian Gómez-Cambronero, Malgorzata Milkiewicz, Piotr Milkiewicz, Bruno Sangro, Verena Keitel, Maria J Monte, Jose Jg Marin, Maite G Fernández-Barrena, Matias A Ávila, Carmen Berasain
Intrahepatic accumulation of bile acids (BA) causes hepatocellular injury. Upon liver damage, a potent protective response is mounted to restore the organ's function. Epidermal growth factor receptor (EGFR) signaling is essential for regeneration after most types of liver damage, including cholestatic injury. However, EGFR can be activated by a family of growth factors induced during liver injury and regeneration. We evaluated the role of the EGFR ligand amphiregulin (AREG) during cholestatic liver injury and the regulation of AREG expression by BA...
November 8, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Sean P Doyle, Saumya S Gurbani, Alexandra S Ross, Havi Rosen, Charlice Dunn Barrett, Jeffrey J Olson, Hyunsuk Shim, Hui-Kuo Shu, Soma Sengupta
The standard treatment for patients diagnosed with glioblastoma is surgical resection of tumor followed by high dose radiation and chemotherapy with temozolomide. For patients who experience allergic reactions to temozolomide despite desensitization protocols, alternative therapies must be considered. In this report, we present such a patient who then received treatment with an epidermal growth factor receptor inhibitor, erlotinib, concurrent with a tumor-treating field device, Optune. Through this combination of a targeted molecular therapy and the Optune device, the patient has been able to achieve stable disease 9 months after completing radiation...
December 2018: Oxford Medical Case Reports
Akito Hata, Nobuyuki Katakami, Reiko Kaji, Toshihide Yokoyama, Toshihiko Kaneda, Motohiro Tamiya, Takako Inoue, Hiromi Kimura, Yukihiro Yano, Daisuke Tamura, Satoshi Morita, Shunichi Negoro
Third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are markedly effective for T790M-positive patients. To confer their clinical benefit to more patients, a novel therapy to induce positive conversion in T790M-negative patients may be possible. We retrospectively reviewed medical records of patients who had received rebiopsy after completion of ABC-study: a prospective phase II study of Afatinib plus Bevacizumab Combination (ABC)-therapy after acquired resistance to EGFR-TKI...
October 5, 2018: Oncotarget
Ji Min Kim, Jung Eun Choo, Ki Nam Kim, Yang Seok Kim
Background: Ultraviolet A (UVA) rays reach the dermal skin layer and generate oxidative stress, DNA damage, and cell inflammation, which in turn lead to photo-aging and photo-carcinogenesis. While there have been many studies about the beneficial effects of topical epidermal growth factor (EGF) treatment in the healing of wounds, the effect of EGF on UVA-induced skin irritation remains unknown. To clarify the effects of EGF on UVA-induced skin damage, it was investigated whether EGF signaling can affect intracellular reactive oxygen species (ROS) and DNA damages in UVA-irradiated human dermal fibroblasts...
2018: Clinical, Cosmetic and Investigational Dermatology
Rong Li, Rajni Chibbar, Jim Xiang
Breast cancer is the leading cause of death in women globally. The human epidermal growth factor receptor 2 (HER2)-positive breast cancer is often associated with poor prognosis and high mortality. Even though anti-HER2 monoclonal antibodies have improved the clinical outcome, resistance to the antibody therapy becomes a major obstacle in the treatment of HER2-positive breast cancer patients. Alternative approaches are therefore needed. HER2-specific vaccines have been developed to trigger patient's immune system against HER2-positive breast cancer...
2018: OncoTargets and Therapy
Pawel Z Kosentka, Alexander M Overholt, Richard Maradiaga, Omar Mitoubsi, Elena D Shpak
The shoot apical meristem (SAM) enables the formation of new organs throughout the life of a plant. ERECTA family (ERf) receptors restrict SAM size and promote initiation of leaves while simultaneously supporting establishment of correct phyllotaxy. In the epidermis and during organ elongation ERf activity is regulated by a family of Epidermal Patterning Factor-Like (EPFL) secreted cysteine-rich small proteins. Here we show that ERfs play a critical role in communication between the SAM leaf boundary and the central zone...
November 8, 2018: Plant Physiology
Kristen M Flatt, Caroline Beshers, Cagla Unal, Jennifer D Cohen, Meera V Sundaram, Nathan E Schroeder
Phenotypic plasticity is a critical component of an organism's ability to thrive in a changing environment. The free-living nematode, Caenorhabditis elegans , adapts to unfavorable environmental conditions by pausing reproductive development and entering a stress-resistant larval stage known as dauer. The transition into dauer is marked by vast morphological changes - including remodeling of epidermis, neurons and muscle. Though many of these dauer-specific traits have been described, the molecular basis of dauer-specific remodeling is still poorly understood...
November 8, 2018: Genetics
Rebecca Gentek, Clément Ghigo, Guillaume Hoeffel, Audrey Jorquera, Rasha Msallam, Stephan Wienert, Frederick Klauschen, Florent Ginhoux, Marc Bajénoff
The murine epidermis harbors two immune cell lineages, Langerhans cells (LCs) and γδ T cells known as dendritic epidermal T cells (DETCs). LCs develop from both early yolk sac (YS) progenitors and fetal liver monocytes before locally self-renewing in the adult. For DETCs, the mechanisms of homeostatic maintenance and their hematopoietic origin are largely unknown. Here, we exploited multicolor fate mapping systems to reveal that DETCs slowly turn over at steady state. Like for LCs, homeostatic maintenance of DETCs is achieved by clonal expansion of tissue-resident cells assembled in proliferative units...
November 8, 2018: Journal of Experimental Medicine
Parul Gupta, Nehal Gupta, Neel M Fofaria, Alok Ranjan, Sanjay K Srivastava
Breast cancer metastasis is a multi-step process and requires cells to overcome anoikis. Anoikis is defined as cell-death that occurs due to loss of cell adhesion. During the course of cancer progression, tumor cells acquire resistance to anoikis. However, mechanisms of anoikis resistance are not clear. Human epidermal growth receptor 2 (HER2) overexpressing breast tumors are known to be highly aggressive and metastatic. The mechanisms correlating HER2 with metastasis are poorly understood. We observed increased anoikis resistance in HER2 overexpressing breast cancer cells...
October 26, 2018: Cancer Letters
Saeid Amini-Nik, Reinhard Dolp, Gertraud Eylert, Andrea-Kaye Datu, Alexandra Parousis, Camille Blakeley, Marc G Jeschke
BACKGROUND: Thermal injuries affect millions of adults and children worldwide and are associated with high morbidity and mortality. The key determinant for the survival of burns is rapid wound healing. Large wounds exceed intrinsic wound-healing capacities, and the currently available coverage materials are insufficient due to lack of cellularity, availability or immunological rejection. METHODS: Using the surgically debrided tissue, we isolated viable cells from burned skin...
October 19, 2018: EBioMedicine
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