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Surfactant D

Ho Yong Son, Bo Ram Chae, Ji Yeh Choi, Dong Jun Shin, Yoon Tae Goo, Eun Seok Lee, Tae Hoon Kang, Chang Hyun Kim, Ho Yub Yoon, Young Wook Choi
To improve the dissolution behavior of telmisartan (TMS), a poorly water-soluble angiotensin II receptor blocker, TMS-phospholipid complex (TPC) was prepared by solvent evaporation method and characterized by differential scanning calorimetry and powder X-ray diffractometry. The crystalline structure of TMS was transited into an amorphous state by TPC formation. The equilibrium solubility of TPC (1.3-6.1 mg/mL) in various vehicles was about 100 times higher than that of TMS (0.009-0.058 mg/mL). TPC-loaded self-microemulsifying drug delivery system (SMEDDS) formulation was optimized using the D-optimal mixture design with the composition of 14% Capryol 90 (oil; X1), 59...
2018: PloS One
Noha Attia, Mohamed Mashal, Cristina Soto-Sánchez, Gema Martínez-Navarrete, Eduardo Fernández, Santiago Grijalvo, Ramón Eritja, Gustavo Puras, Jose Luis Pedraz
Background: Gene therapy can be an intriguing therapeutic option in wide-ranging neurological disorders. Though nonviral gene carriers represent a safer delivery system to their viral counterparts, a thorough design of such vehicles is crucial to enhance their transfection properties. Purpose: This study evaluated the effects of combined use of two nonionic surfactants, poloxamer 188 (P) and polysorbate 80 (P80) into nanovesicles - based on 2,3-di(tetradecyloxy)propan-1-amine cationic lipid (D) - destined for gene delivery to central nervous system cells...
2018: Drug Design, Development and Therapy
Diego Ramirez, Chris D Collins
Worldwide the generation of oil sludges is approximately 160 million metric tonnes per annum. The washing of oil sludge with surfactant solutions can be used to recover the oil and reused as a feedstock for fuel production. There is a need to establish the influence of the surfactant type, concentration, and application (surfactant to oil sludge, S/OS) ratio to oil sludge for the maximisation of oil recovery. This study presented the oil recovery rates from the washing of an oil-water separator sludge using surfactants, Triton X-100, sodium dodecyl sulphate (SDS), Tween 80, rhamnolipid, and Triton X-114...
December 2018: Waste Management
Shijuan Zhang, Ting Xu, Qian Liu, Jiammin Liu, Fengli Lu, Mingbo Yue, Yanxin Li, Zhiwei Sun, Jinmao You
A new cationic gemini surfactant-resorcinol/formaldehyde resin was designed and synthesized. Cationic gemini surfactant was introduced into the resorcinol/formaldehyde resin for the first time and led to the retention of negatively charged endocrine disrupting compounds (EDCs) through electrostatic interactions, hydrogen bonding and π-π interactions. The synthesized material showed good performance in the dispersive micro-solid phase extraction (D-μ-SPE) of EDCs such as alkylphenol and phenoxy acid herbicides from food packaging migrants...
March 30, 2019: Food Chemistry
Monika Gasztych, Krystyna Komsa, Witold Musia
Polymers sensitive to external stimuli are intensively studied. They are used for preparation of controlled drug delivery systems for variety of active pharmaceutical ingredients. Poly- N -isopropyl acrylamide is a temperature sensitive polymer, and its properties have been used to obtain a series of thermally sensitive polymeric structures. The present study evaluates the effect of hydrophilic co-monomer, N -(2-hydroxyethyl)acrylamide on the properties of thermosensitive hydrogels with hydroxypropyl methylcellulose and assesses the release rate of the model drug naproxen sodium embedded into the hydrogel...
May 1, 2019: Journal of Nanoscience and Nanotechnology
Rahul P Patil, Devlya D Pawara, Chetan S Gudewar, Avinash R Tekade
The purpose of this research was to develop cubosomal mucoadhesive in situ nasal gel to enhance the donepezil HCl delivery to the brain. Glycerol mono-oleate (GMO) and surfactant poloxamer 407 were used to prepare cubosomes. The developed formulations were characterized for particle size (PS), poly dispersity index (PDI), zeta potential (ZP), entrapment efficiency (EE), transmission electron microscopy (TEM), in vitro drug release and in vivo bio-distribution study in blood and brain tissue. Central composite design was used for the optimization purpose and the selected formulation (containing GMO 2g and poloxamer 1...
December 2, 2018: Journal of Liposome Research
Yu-Zhou Wang, Tian Chen, Hai-Hui Liu, Xue-Chen Wang, Xing-Xiang Zhang
Graphene has attracted a great number of attentions due to the excellent physical and chemical properties. For the convenience of investigations and applications, it is crucial to produce the grapheme with high-quality and high-yield by an easy-obtained method. In this research, a promising method is demonstrated to produce a high-concentration few-layer graphene (FLG) dispersion by direct microfluidization in water/surfactant systems. The effects of surfactant selection, chamber pressure and microfluidization cycles on the graphitic material exfoliation efficiency are systematically studied...
April 1, 2019: Journal of Nanoscience and Nanotechnology
Ana Luísa Cartaxo, Ana R Costa-Pinto, Albino Martins, Susana Faria, Virgínia M F Gonçalves, Maria Elizabeth Tiritan, Helena Ferreira, Nuno M Neves
Polymeric nanoparticles (NPs) are strong candidates for the development of systemic and targeted drug delivery applications. Their size is a determinant property since it defines the NP-cell interactions, drug loading capacity, and release kinetics. Herein, poly(d,l-lactic acid) (PDLA) NPs were produced by the nanoprecipitation method, in which the influence of type and concentration of surfactant as well as PDLA concentration were assessed. The adjustment of these parameters allowed the successful production of NPs with defined medium sizes, ranging from 80 to 460 nm...
November 28, 2018: Journal of Biomedical Materials Research. Part A
D Ferraro, M Serra, D Filippi, L Zago, E Guglielmin, M Pierno, S Descroix, J-L Viovy, G Mistura
Droplet microfluidics is a powerful technology that finds many applications in chemistry and biomedicine. Among different configurations, droplets confined in a capillary (or plugs) present a number of advantages: they allow positional identification and simplify the integration of complex multi-steps protocols. However, these protocols rely on the control of droplet speed, which is affected by a complex and still debated interplay of various physico-chemical parameters like droplet length, viscosity ratio between droplets and carrier fluid, flow rate and interfacial tension...
November 28, 2018: Lab on a Chip
A Barra Caracciolo, N Ademollo, M Cardoni, A Di Giulio, P Grenni, T Pescatore, J Rauseo, L Patrolecco
The anionic surfactant sodium lauryl ether sulphate (SLES) is the main component in most foaming agents used for mechanized tunneling excavation. The process produces huge amounts of soil debris that can have a potential impact on ecosystems. The lack of accurate information about SLES persistence in excavated soil has aroused increasing concern about how it is recycled. The objective of this study was to assess SLES biodegradability in two commercial foaming agents (P1 and P2). Microcosm experiments were performed with two different soils collected from a tunnel construction site and conditioned with P1 or P2 (85...
November 3, 2018: Journal of Hazardous Materials
Timothy T Duignan, Mengsu Peng, Anh V Nguyen, X S Zhao, Marcel D Baer, Christopher J Mundy
The surface tension of dilute salt water is a fundamental property that is crucial to understanding the complexity of many aqueous phase processes. Small ions are known to be repelled from the air-water surface leading to an increase in the surface tension in accordance with the Gibbs adsorption isotherm. The Jones-Ray effect refers to the observation that at extremely low salt concentration, the surface tension decreases. Determining the mechanism that is responsible for this Jones-Ray effect is important for theoretically predicting the distribution of ions near surfaces...
November 21, 2018: Journal of Chemical Physics
Pavani P Nadiminti, Qingtao Liu, Lavanya K Vanjari, Yao D Dong, Ben J Boyd, David M Cahill
BACKGROUND: Modern agricultural practises rely on surfactant-based spray applications to eliminate weeds in crops. The wide spread and indiscriminate use of surfactants may result in a number of deleterious effects that are not limited to impacts on the crop and surrounding farm eco-system but include effects on human health. To provide a safer alternative to the use of surfactant-based formulations, we have synthesised a novel, self-assembling herbicide conjugate for the delivery of a broad leaf herbicide, picloram...
November 21, 2018: Journal of Nanobiotechnology
Nithyananda Thorenoor, Todd M Umstead, Xuesheng Zhang, David S Phelps, Joanna Floros
Surfactant protein A (SP-A) is involved in lung innate host defense and surfactant-related functions. The human SFTPA1 and SFTPA2 genes encode SP-A1 and SP-2 proteins, and each gene has been identified with numerous genetic variants. SP-A1 and SP-A2 differentially enhance bacterial phagocytosis. Sex differences have been observed in pulmonary disease and in survival of wild type and SP-A knockout (KO) mice. The impact of human SP-A variants on survival after infection is unknown. In this study, we determined whether SP-A variants differentially affect survival of male and female mice infected with Klebsiella pneumoniae ...
2018: Frontiers in Immunology
Snežana P Maletić, Jelena M Beljin, Srđan D Rončević, Marko G Grgić, Božo D Dalmacija
Polycyclic aromatic hydrocarbons (PAHs) are amongst the most abundant contaminants found in the aquatic environment. Due to their toxicity and carcinogenicity, their sources, fate, behaviour, and cleanup techniques have been widely investigated in the last several decades. When entering the sediment-water system, PAH fate is determined by particular PAH and sediment physico-chemical properties. Most of the PAHs will be associated with fine-grained, organic-rich, sediment material. This makes sediment an ultimate sink for these pollutants...
November 12, 2018: Journal of Hazardous Materials
Agata Zdarta, Amanda Pacholak, Wojciech Smułek, Agnieszka Zgoła-Grześkowiak, Nadège Ferlin, Abed Bil, José Kovensky, Eric Grand, Ewa Kaczorek
Development of many branches of industry has stimulated the search for new, effective surfactants with interesting properties. Potential use of alkyl glucose derivatives on a large scale, raises questions about the possible risks associated with their entry into the natural environment. To be able to evaluate this risk, the aim of the study was to determine the physicochemical properties of octyl d-glucopyranoside and its three derivatives: N-(octyl d-glucopyranosiduronyl)aspartic acid, N-(octyl d-glucopyranosiduronyl)glicyne and octyl d-glucopyranosiduronic acid...
November 5, 2018: Chemosphere
Bei-Xing Li, Yang Liu, Peng Zhang, Xiao-Xu Li, Xiu-Yu Pang, Yun-He Zhao, Hua Li, Feng Liu, Jin Lin, Wei Mu
In this study, the bioactivities of binary mixtures of organosilicone surfactants and indoxacarb against two Lepidopteran pests were investigated along with their environmental risks. All of the tested organosilicone surfactants had obvious synergistic effects on the contact toxicity of indoxacarb against Spodoptera exigua and Agrotis ipsilon. However, all of the organosilicone surfactants exhibited certain antagonism for indoxacarb against S. exigua in terms of stomach & contact toxicity; both Silwet-408 and Silwet-806 exhibited additivity against A...
November 10, 2018: Chemosphere
Tomoaki Miura, Kiminori Maeda, Yoshimi Oka, Tadaaki Ikoma
For realization of low-cost organic photon-energy conversion, the supramolecular approach has been a focus of attention as a counter approach to precise synthesis of covalently linked donor (D)-acceptor (A) molecules. Here we report photogeneration of a long-lived (∼3 μs) intermolecular charge-separated (CS) state of metal porphyrins (D) and an alkyl viologen (A) at an interface of a vesicle membrane formed by self-assembly of nonionic surfactant and cholesterol molecules. The yield of escaped free radicals is negligibly low as in the case of CS states in covalently linked D-A systems...
November 30, 2018: Journal of Physical Chemistry. B
Yu Jin Kim, Richard D Schaller, Harry Christopher Fry
This article describes p-n heterostructured water-borne semiconductor naonoparticles (NPs) with unique surface structures via control of shell morphology. The shell particles, comprising PC60-[6,6]-phenyl-C61-butyric acid methyl ester (PC61 BM) composite, having n-type semiconductor characteristics, notably influence the charge carrier behavior in the core-shell NPs. A one- or two-phase methodology based on a PC60 surfactant-water phase and PC61 BM n-type semiconductor-organic phase provides highly specific control over the shell structure of the NPs, which promote their superior charge separation ability when combined with poly-3-hexyl-thiophene (P3HT)...
November 14, 2018: Small
M Vasilakaki, N Ntallis, N Yaacoub, G Muscas, D Peddis, K N Trohidou
Ferrofluids of CoFe2 O4 nanoparticles are gaining increasing interest due to their enhanced heating performance in biomedical applications (e.g. in magnetic hyperthermia as mediators for cancer treatment) or in energy applications (e.g. magneto-thermo-electric applications). Until now, the effect of an organic surfactant on the magnetic particle behaviour has been unintentionally overlooked. Here, we present the counterintuitive magnetic effect of two representative organic ligands: diethylene glycol (DEG) and oleic acid (OA) bonded at the surface of small (∼5 nm in size) CoFe2 O4 particles...
December 7, 2018: Nanoscale
D C Wolf, J Gan
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants in soil and are considered priority pollutants due to their carcinogenicity. Bioremediation of PAH-contaminated soils is often limited by the low solubility and strong sorption of PAHs in soil. Synthetic surfactants and biosurfactants have been used to enhance the bioavailability of PAHs and to accelerate microbial degradation. However, few studies have compared synthetic and biosurfactants in their efficiency in promoting PAH biodegradation in either native or bioaugmented soils...
December 2018: Environmental Pollution
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