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Surfactant D

Jens Madsen, Madhurban H Panchal, Rose-Marie Mackay, Mercedes Echaide, Grielof Koster, Giancarlo Aquino, Nicola Pelizzi, Jesus Perez-Gil, Fabrizio Salamone, Howard W Clark, Anthony D Postle
Secreted pulmonary surfactant phosphatidylcholine (PC) has a complex intra-alveolar metabolism involving uptake and recycling by alveolar type II epithelial cells, catabolism by alveolar macrophages and loss up the bronchial tree. Here we compared the metabolism in vivo in adult mice of animal-derived Poractant alpha (Curosurf) and a synthetic surfactant (CHF5633). Adult male C57BL/6 were dosed intra-nasally with either surfactant (80 mg/kg body weight) containing as tracer universally 13C- labelled dipalmitoyl PC (U13C-DPPC)...
August 14, 2018: Journal of Lipid Research
Mohammed N Al-Ahdal, Valarmathy Murugaiah, Praveen M Varghese, Suhair M Abozaid, Iram Saba, Ahmed Ali Al-Qahtani, Ansar A Pathan, Lubna Kouser, Béatrice Nal, Uday Kishore
Surfactant protein D (SP-D) is expressed in the mucosal secretion of the lung and contributes to the innate host defense against a variety of pathogens, including influenza A virus (IAV). SP-D can inhibit hemagglutination and infectivity of IAV, in addition to reducing neuraminidase (NA) activity via its carbohydrate recognition domain (CRD) binding to carbohydrate patterns (N-linked mannosylated) on NA and hemagglutinin (HA) of IAV. Here, we demonstrate that a recombinant fragment of human SP-D (rfhSP-D), containing homotrimeric neck and CRD regions, acts as an entry inhibitor of IAV and downregulates M1 expression considerably in A549 cells challenged with IAV of H1N1 and H3N2 subtypes at 2 h treatment...
2018: Frontiers in Immunology
D Dixit, D Gangadharan, K M Popat, C R K Reddy, M Trivedi, D K Gadhavi
A simple and eco-friendly method for the synthesis of hybrid bead silver nanoparticles (AgNPs) employing the aqueous extract derived from natural and renewable source namely tropical benthic green seaweed Ulva flexuosa was developed. This route involves the reduction of Ag+ ions anchored onto macro porous methacrylic acid copolymer beads to AgNPs for employing them as antibacterial agents for in vitro water disinfection. The seaweed extract itself acts as a reducing and stabilizing agent and requires no additional surfactant or capping agent for forming the AgNPs...
August 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Milos Brankovic, K Martijn Akkerhuis, Henk Mouthaan, Alina Constantinescu, Kadir Caliskan, Jan van Ramshorst, Tjeerd Germans, Victor Umans, Isabella Kardys
BACKGROUND: Our aim was to explore potential use of temporal profiles of seven emerging cardio-renal and two pulmonary candidate biomarkers for predicting future adverse clinical outcome in stable patients with chronic heart failure (CHF). METHODS: In 263 CHF patients, we determined the risk of a composite endpoint of HF-hospitalization, cardiac death, LVAD-placement and heart transplantation in relation to repeatedly assessed (567 samples in total) blood biomarker levels, and slopes of their temporal trajectories (i...
August 3, 2018: International Journal of Cardiology
Sunjie Ye, May C Wheeler, James R McLaughlan, Abiral Tamang, Christine P Diggle, Oscar Cespedes, Alex F Markham, P Louise Coletta, Stephen D Evans
Gold nanoparticles-enabled intracellular surface-enhanced Raman spectroscopy (SERS) provides a sensitive and promising technique for single cell analysis. Compared with spherical gold nanoparticles, gold nanoflowers, i.e., flower-shaped gold nanostructures, can produce a stronger SERS signal. Current exploration of gold nanoflowers for intracellular SERS has been considerably limited by the difficulties in preparation, as well as background signal and cytotoxicity arising from the surfactant capping layer. Recently, we have developed a facile and surfactant-free method for fabricating hollow-channel gold nanoflowers (HAuNFs) with great single-particle SERS activity...
August 8, 2018: International Journal of Molecular Sciences
Lars Knudsen, Elena Lopez-Rodriguez, Lennart Berndt, Lilian Steffen, Clemens Ruppert, Jason H T Bates, Matthias Ochs, Bradford J Smith
RATIONALE: Lung injury results in intra-tidal alveolar recruitment and derecruitment (R/D) and alveolar collapse, creating stress concentrators that increase strain and aggravate injury. OBJECTIVE: To describe alveolar micromechanics during mechanical ventilation in bleomycin-induced lung injury and surfactant replacement therapy. METHODS: Structure and function were assessed in rats one (D1) and three (D3) days after intratracheal bleomycin instillation and subsequent to surfactant replacement therapy (SRT)...
August 10, 2018: American Journal of Respiratory Cell and Molecular Biology
Pingkeng Wu, Alex D Nikolov, Darsh T Wasan
Surfactant solutions containing polymeric nanoparticles have been shown to have an improved wetting and spreading on solid surfaces. In this work, we explored the effect of the polymeric nanoparticles on the frictional coefficient at the three-phase contact region by studying polymeric nanofluids displacing oil in capillaries. Our results show polymeric nanoparticles can reduce the frictional coefficient by as much as four times by forming structured layers in the confined wedge film. We also demonstrate the role of the interfacial tension in affecting the frictional coefficient...
July 20, 2018: Journal of Colloid and Interface Science
Nicola Ronan, Deirdre M Bennett, Kashif A Khan, Yvonne McCarthy, Darren Dahly, Louise Bourke, Adeline Chelliah, Alberto Cavazza, Kevin O'Regan, Fiachra Moloney, Barry J Plant, Michael T Henry
BACKGROUND: Pirfenidone is a novel anti-fibrotic agent in idiopathic pulmonary fibrosis with proven clinical benefit. Better human tissue models to demonstrate the immunomodulatory and anti-fibrotic effect of pirfenidone are required. OBJECTIVES: The purpose of the study was to use transbronchial lung cryobiopsy (TBLC), a novel technique which provides substantial tissue samples, and a large panel of biomarkers to temporally assess disease activity and response to pirfenidone therapy...
July 31, 2018: Lung
Andrea E Restrepo, José D Rojas, Omar R Garcia, Leidy T Sanchez, Magda I Pinzon, Cristian C Villa
Edible films are among the most promising fields in food science over the last decade due to their versatility (they can be made from a wide array of materials) and because they can be used as carriers of different active substances, like antioxidants, antimicrobial agents, and essential oils from plants. In the case of the essential oils, their inclusion in edible films is limited by their low water solubility. Nanoemulsions are thermodynamically stable and transparent systems that can be used as a way of incorporating essential oils into edible film matrices...
July 31, 2018: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
Z H Fu, Z Y Jiang, W Sun, Z F Xiong, X C Liao, M Z Liu, B Xu, G H Guo
Objective: To investigate the effect of recombinant human keratinocyte growth factor 2 (rhKGF-2) on lung tissue of rabbits with severe smoke inhalation injury. Methods: A total of 120 New Zealand rabbits were divided into 5 groups by random number table after being inflicted with severe smoke inhalation injury, with 24 rats in each group. Rabbits in the simple injury group inhaled air, while rabbits in the injury+phosphate buffer solution (PBS) group inhaled 5 mL PBS once daily for 7 d. Rabbits in injury+1 mg/kg rhKGF-2 group, injury+2 mg/kg rhKGF-2 group, and injury+5 mg/kg rhKGF-2 group received aerosol inhalation of 1 mg/kg, 2 mg/kg, and 5 mg/kg rhKGF-2 (all dissolved in 5 mL PBS) once daily for 7 d, respectively...
July 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Vasanthi R Sunil, Kinal N Vayas, Jessica A Cervelli, Elena Ebramova, Andrew J Gow, Michael Goedken, Jeffrey D Laskin, Debra L Laskin
Nitrogen mustard (NM) is a vesicant known to cause acute pulmonary injury which progresses to fibrosis. Macrophages contribute to both of these pathologies. Surfactant protein (SP)-D is a pulmonary collectin that suppresses lung macrophage activity. Herein, we analyzed the effects of loss of SP-D on NM-induced macrophage activation and lung toxicity. Wild type (WT) and SP-D-/- mice were treated intratracheally with PBS or NM (0.08 mg/kg). Bronchoalveolar lavage fluid (BAL) and tissue were collected 14 d later...
July 30, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Maria John Newton, Rimple
BACKGROUND: Brimonidine tartrate (BRT) is used in treatment of glaucoma. Brimonidine tartrate nanoemulsion was fabricated in this research work to enhance the permeability through barriers and faster onset of action and therapeutic effect. OBJECTIVE: To fabricate an ocular compatible nanoemulsion of Brimonidine tartrate by using surfactant and co-surfactants. METHODS: The experimental work involved compatibility studies by using FTIR, DSC and the crystallinity study by XRD...
July 29, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
Mounira Habli, Corey C Clifford, Tammy M Brady, Zahidee Rodriguez, Michaela Eschenbacher, Malcolm Wu, Emily DeFranco, James Gresh, Beena D Kamath-Rayne
Nonsteroidal anti-inflammatory drugs (NSAIDs) are used as tocolytics, which are medications that suppress uterine contractions for preterm birth prevention. Their effect on cerebral/systemic vascular beds poses the question of whether antenatal NSAID exposure is associated with neonatal hypertension. We performed a retrospective case-control study in a tertiary neonatal intensive care unit, including 40 hypertension cases (hospitalized neonates ≥ 35 weeks with systolic BP > 100 mm Hg on three consecutive days) compared to 134 controls matched by gestational age at delivery, plurality, and delivery date...
July 27, 2018: Journal of Clinical Hypertension
Xuan Yang, Zhi Yan, Tao Yu, Yingxiang Du, Jiaquan Chen, Zongran Liu, Ying Xi
Several chiral reagents including cyclodextrins (CDs) and derivatives, crown ethers, proteins, chiral surfactants, and polymers have been involved in dual-selector systems for enantioseparation of a series of compounds by capillary electrophoresis (CE). In this paper, chondroitin sulfate D-based dual-selector system (CSD/CM-β-CD) was firstly established and investigated for the enantioseparation of six basic racemic drugs in capillary electrophoresis. Compared to the single-selector systems, synergistic effect and significantly improved separations for all tested analytes were observed in CSD/CM-β-CD system...
July 24, 2018: Analytical and Bioanalytical Chemistry
Lei Zou, So Yoon Lee, Qi Wu, Haoyun Zhang, Anthony Bastian, Cara Orji, Gregory Payne, Adriana Galvez, Tima Thomas, Zijian Zhang, Huanyu Dou
Convenient methods for the preparation of gene delivery platforms based on branched low molecular weight polyethylenimine (PEI) were described. Firstly, PEI lipids, with a low molecular weight PEI headgroup and hexadecyl chain tail group, were prepared through a highly efficient ring-opening reaction of glycidyl hexadecyl ether (EpoxyC16) by amine from PEI. Then, the PEI lipids were used as a component of cationic liposomes and as a surfactant for the preparation of poly(D,L-lactide-co-glycolide) (PLGA) nanoparticle (NP) via solvent extraction/evaporation method...
October 1, 2018: Journal of Biomedical Nanotechnology
Iram Shahzadi, Aida Dizdarević, Nuri Ari Efiana, Barbara Matuszczak, Andreas Bernkop-Schnürch
It was the aim of this study to prepare trypsin decorated mucus permeating self-emulsifying drug delivery systems (SEDDS). Lipophilicity of enzyme was increased by hydrophobic ion pairing (HIP) with the anionic surfactants sodium dodecyl sulfate (SDS), sodium taurocholate (ST) and sodium deoxycholate (SDO) to facilitate its incorporation in SEDDS. Blank SEDDS and trypsin decorated SEDDS were characterized regarding droplet size, polydispersity index (PI), zeta potential and proteolytic activity using Nα-benzoyl-l-arginine ethyl ester (BAEE) assay...
July 17, 2018: Journal of Colloid and Interface Science
Andrew D Dillon, Shawn Mengel, Aaron T Fafarman
For electrophoretic deposition (EPD) to achieve its potential as a method for assembling functional semiconductors, it will be necessary to understand both what governs the threshold voltage for deposition and how to reduce that threshold. Herein we demonstrate that postsynthetic modification of the surface chemistry of all-inorganic copper zinc tin sulfide (CZTS) nanocrystals (NCs) enables EPD at voltages of as low as 4 V, which is a 3-fold or greater reduction over previous examples of nonoxide semiconductors...
August 10, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Corina Vasilescu, M Latikka, K D Knudsen, V M Garamus, V Socoliuc, Rodica Turcu, Etelka Tombácz, Daniela Susan-Resiga, R H A Ras, L Vékás
This paper is an in-depth analysis devoted to two basic types of water based magnetic fluids (MFs), containing magnetite nanoparticles with electrostatic and with electro-steric stabilization, both obtained by chemical coprecipitation synthesis under atmospheric conditions. The two sets of magnetic fluid samples, one with citric acid (MF/CA) and the other with oleic acid (MF/OA) coated magnetic nanoparticles, respectively, achieved saturation magnetization values of 78.20 kA m-1 for the electrostatically and 48...
July 23, 2018: Soft Matter
Kishan Veerabrahma, Venu Madhav Katla
BACKGROUND: FR&D scientists continuously try to increase the in vivo performance of low soluble and bioavailable drugs. Solid SMEDDS and liquisolid formulations are relatively simple to develop and fall within the novel drug delivery approaches. Here, a comparison is made to know relative superiority. OBJECTIVE: To conduct comparative pharmacokinetic (PK) and pharmacodynamic (PD) studies of developed Fluvastatin (FLU) solid SMEDDS (SSMED) and liquisolid formulation (LS) for their relative in vivo efficacy...
July 22, 2018: Current Drug Delivery
Matthias Krause, Nicole Peukert, Wolfgang Härtig, Alexander Emmer, Cynthia Vanessa Mahr, Cindy Richter, Julia Dieckow, Joana Puchta, Mandy Pirlich, Karl-Titus Hoffmann, Ulf Nestler, Stefan Schob
Conventional surfactant proteins (A, B, C, and D) are important players of the innate immunity in the central nervous system and serve as effective regulators of cerebrospinal fluid rheology, probably being involved in clearance of detrimental metabolites like beta-amyloid and phospho-tau. Recently, a novel surfactant protein, SP-G, was described in kidneys and peripheral endocrine and exocrine glands. So far, its presence and possible functions in the central nervous system are unknown. Therefore, our study aimed to elucidate the presence of SP-G in the brain and its concentration in normal and pathologic samples of cerebrospinal fluid in order to gain first insight into its regulation and possible functions...
July 21, 2018: Molecular Neurobiology
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