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Surfactant D

Pavan M V Raja, Gibran L Esquenazi, Kourtney D Wright, Cathren E Gowenlock, Bruce E Brinson, Shirin Alexander, Daniel R Jones, Varun Shenoy Gangoli, Andrew R Barron
The electromigration behaviour of raw and acid purified single walled carbon nanotubes (SWCNTs) in dilute aqueous systems (0.0034 mg mL-1), in the absence of surfactant, with the addition of either 0.85 M acetic acid or 0.1 M CuSO4, was evaluated using a 2-inch copper cathode and either a 2-inch copper or 0.5-inch platinum anode. The results showed that the electromigration of raw SWCNTs (with a high catalyst residue) in the presence of CuSO4 resulted in the formation of a Cu-SWCNT composite material at the cathode...
October 16, 2018: Nanoscale
Sravanthi Cheeti, Hao Helen Hou, Eric Nelson, Helen Walker, Buyun Chen, Roland Morley, Mary Gates, Luna Musib, Sandhya Girish, Srikumar Sahasranaman, Lichuan Liu
PURPOSE: GDC-0810, administered orally, was used in Phase I and II clinical studies to treat estrogen receptor positive breast cancers. It contains N-methyl-D-glucamine (NMG) salt of GDC-0810 with 10% sodium lauryl sulfate (SLS) as a surfactant and 15% sodium bicarbonate (NaHCO3 ) as an alkalizing agent to aid dissolution. To improve the processability of the formulation and reduce potential mucosal irritation in future Phase III clinical studies, the salt form and the amount of excipient required further optimization...
October 15, 2018: Pharmaceutical Research
Meng Xu, Zhihua Jiang, Wen Huang, Jianhai Yin, Shen Ou, Yanyan Jiang, Liyu Meng, Shengkui Cao, Aiping Yu, Jianping Cao, Yujuan Shen
Clonorchiasis is an infectious disease caused by helminths of Clonorchis sinensis ( C. sinensis ). The adult parasite mainly inhabits the bile duct and gall bladder, and results in various complications to the hepatobiliary system. The amount of bile secreted into the intestine is reduced in cases of C. sinensis infection, which may alter the pH of the gut and decrease the amount of surfactant protein D released from the gallbladder. However, the impact of parasitic infection on the human gut microbiome remains unclear...
2018: Frontiers in Microbiology
Roberta Guagliardo, Jésus Pérez-Gil, Stefaan De Smedt, Koen Raemdonck
Pulmonary surfactant (PS) has been extensively studied because of its primary role in mammalian breathing. The deposition of this surface-active material at the alveolar air-water interface is essential to lower surface tension, thus avoiding alveolar collapse during expiration. In addition, PS is involved in host defense, facilitating the clearance of potentially harmful particulates. PS has a unique composition, including 92% of lipids and 8% of surfactant proteins (SPs) by mass. Although they constitute the minor fraction, SPs to a large extent orchestrate PS-related functions...
October 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Yao-Xing Dou, Jiang-Tao Zhou, Tong-Tong Wang, Yan-Feng Huang, Vicky Ping Chen, You-Liang Xie, Zhi-Xiu Lin, Jian-Sheng Gao, Zi-Ren Su, Hui-Fang Zeng
Background: Bruceine D (BD) is a major bioactive component isolated from the traditional Chinese medicinal plant Brucea javanica which has been widely utilized to treat dysentery (also known as ulcerative colitis [UC]). Methods: To improve the water solubility and absolute bioavailability of BD, we developed a self-nanoemulsifying drug delivery system (SNEDDS) composing of MCT (oil), Solutol HS-15 (surfactant), propylene glycol (co-surfactant) and BD. The physicochemical properties and pharmacokinetics of BD-SNEDDS were characterized, and its anti-UC activity and potential mechanism were evaluated in TNBS-induced UC rat model...
2018: International Journal of Nanomedicine
Steffen Kunzmann, Barbara Ottensmeier, Christian P Speer, Markus Fehrholz
Pregnant women at risk of preterm labor routinely receive glucocorticoids (GCs) and frequently also progesterone. Administration of GCs accelerates intrauterine surfactant synthesis and lung maturation, thereby reducing the incidence of neonatal respiratory distress syndrome; progesterone has the potential to prevent preterm birth. Little is known about possible interactions of GCs and progesterone. Our aim was to clarify whether progesterone can affect dexamethasone (DXM)-regulated expression of surfactant protein A (SP-A), SP-B, and SP-D in lung epithelial cells...
October 15, 2018: Reproductive Sciences
Silvia Pescina, Gabriela Garrastazu, Elena Del Favero, Valeria Rondelli, Laura Cantù, Cristina Padula, Patrizia Santi, Sara Nicoli
Imiquimod (IMQ) is an immunostimulant drug topically used for the treatment of actinic keratosis and basal cell carcinoma. IMQ formulation and skin delivery is difficult because of its very low solubility in the most of pharmaceutical excipients and very poor skin penetration properties. The purpose of this study was to develop a microemulsion to optimize imiquimod skin delivery using d‑α‑tocopherol polyethylene glycol-1000 succinate (TPGS) as surfactant (so as to take advantage of its thickening properties) and isostearic acid as oil phase...
October 11, 2018: European Journal of Pharmaceutical Sciences
Fatima Khan, Mohammad Yaqoob, Muhammad Asghar, Shahzia Iqbal, Samar Ali, Amir Waseem, Abdul Nabi
A flow injection based chemiluminescence process has been reported for vitamin D3 determination without using especial chemiluminescence reagent. Vitamin D3 shows enhancement on the CL intensity of diperiodatocuprate(III) with surfactant (Triton X-100) solution. The calibration curve was found to be linear over the concentration range 0.01-40 mg/L (R2  = 0.9997, n = 8) tested. A limit of detection (S/N = 3), limit of quantification (S/N = 10) and sample injection throughput of 2.5 × 10-3 , 8...
October 4, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
D E Turney, M Ansari, D V Kalaga, R Yakobov, S Banerjee, J B Joshi
Bioreactors are of interest for gas-to-liquid conversion of stranded or waste industrial gases, such as CO, CH4 , or syngas. Process economics requires reduction of bioreactor cost and size while maintaining intense production via rapid delivery of gases to the liquid phase (i.e., high kL a). Here, we show a novel bioreactor design that outperforms all known technology in terms of gas transfer energy efficiency (kL a per power density) while operating at high kL a (i.e., near 0.8 s-1 ). The reactor design uses a micro-jet array to break feedstock gas into a downward microbubble flow...
October 7, 2018: Biotechnology Progress
Alastair Watson, Maximillian J S Phipps, Howard W Clark, Chris-Kriton Skylaris, Jens Madsen
Innate recognition of viruses is an essential part of the immune response to viral pathogens. This is integral to the maintenance of healthy lungs, which are free from infection and efficient at gaseous exchange. An important component of innate immunity for identifying viruses is the family of C-type collagen-containing lectins, also known as collectins. These secreted, soluble proteins are pattern recognition receptors (PRRs) which recognise pathogen-associated molecular patterns (PAMPs), including viral glycoproteins...
October 5, 2018: Journal of Innate Immunity
Hayakazu Sumida, Yoshihide Asano, Zenshiro Tamaki, Naohiko Aozasa, Takashi Taniguchi, Tetsuo Toyama, Takehiro Takahashi, Yohei Ichimura, Shinji Noda, Kaname Akamata, Ryosuke Saigusa, Miki Miyazaki, Yoshihiro Kuwano, Koichi Yanaba, Ayumi Yoshizaki, Shinichi Sato
There have been no established parameters to predict responsiveness to i.v. cyclophosphamide (IVCY) pulse therapy in combination with corticosteroids in patients with interstitial lung disease (ILD) related to systemic sclerosis (SSc). This retrospective study was conducted to determine predictive factors for efficacy of IVCY at the time of before and during the treatment. Thirty-two Japanese SSc patients, ever treated for ILD with IVCY in combination with prednisolone, were analyzed retrospectively. We performed detailed time-course analyses of parameters derived from blood samples and pulmonary function tests...
October 5, 2018: Journal of Dermatology
Yicheng Zhang, Liangzhu Feng, Jun Wang, Danlei Tao, Chao Liang, Liang Cheng, Erhong Hao, Zhuang Liu
Development of nanoagents with strong near-infrared (NIR) absorbance and high photothermal conversion capacity is highly desired for efficient photoacoustic (PA) imaging and photothermal therapy of cancers. Herein, surfactant-stripped micelles with photostable near-infrared dye, β-thiophene-fused BF2 -azadipyrromethene (aza-BDTP), are prepared in the presence of paclitaxel (PTX) with Pluronic F127 as the surfactant. Distinct from hydrophobic aza-BDTP and PTX, the obtained surfactant-stripped micelles aza-BDTP/PTX show excellent solubility, physiological stability, and high loading efficiencies for corresponding aza-BDTP and PTX...
October 4, 2018: Small
E Michael Danielsen, Gert H Hansen
The small intestinal epithelium constitutes a major permeability barrier for the oral administration of therapeutic drugs with poor bioavailability, and permeation enhancers (PEs) are required to increase the paracellular and/or transcellular uptake of such drugs. Many PEs act as surfactants by perturbing cell membrane integrity and causing permeabilization by leakage or endocytosis. The aim of the present work was to study the action of sodium cholate (NaC) and N-dodecyl-β-D-maltoside (DDM), using a small intestinal mucosal explant system...
October 2, 2018: Pharmaceutics
Zachary D Fox, Guihua Jiang, Kenneth K Y Ho, Kendal A Walker, Allen P Liu, Shaun M Kunisaki
BACKGROUND: The purpose of this study was to employ a novel ex vivo lung model of congenital diaphragmatic hernia (CDH) to determine how a mechanical compression affects early pulmonary development. METHODS: Day-15 whole fetal rat lungs (n = 6-12/group) from nitrofen-exposed and normal (vehicle only) dams were explanted and cultured ex vivo in compression microdevices (0.2 or 0.4 kPa) for 16 h to mimic physiologic compression forces that occur in CDH in vivo...
November 2018: Journal of Surgical Research
Titto Mathew, S K S Sarada
BACKGROUND: Pulmonary surfactant oxidation leads to alveolar collapse- a condition often noticed in high altitude pulmonary edema (HAPE). The present study was aimed to determine the effect of curcumin prophylaxis in augmenting the phase II antioxidant enzymes and surfactant proteins expression in enabling the pulmonary surfactant homeostasis under hypoxia. METHODS: A549 cells were exposed to 3% hypoxia for different time durations (1 h, 3 h, 6 h, 12 h and 24 h)...
September 27, 2018: Respiratory Physiology & Neurobiology
Concepción Abril, Juan Luis Santos, José Luis Malvar, Julia Martín, Irene Aparicio, Esteban Alonso
A method for the determination of 23 emerging concern pollutants in digested sludge, compost and soil has been developed. Target pollutants include six perfluorinated compounds (5 perfluorocarboxylic acids and perfluorooctanesulfonic acid), the plasticizer bisphenol A, four anionic surfactants (sodium alkylsulfates), four preservatives (parabens), two antimicrobial agents (triclosan and triclocarban) and six UV-filters (benzophenones). Sample treatment was based on ultrasound-assisted extraction with 3 mL of methanol:acetic acid (95:5, v/v) and clean-up by dispersive solid-phase extraction (d-SPE) with C18...
September 17, 2018: Journal of Chromatography. A
Xiangyu Chen, Xinrui Ma, Ci Yan, Dejun Sun, Tony Yeung, Zhenghe Xu
A CO2 -responsive superamphiphile was designed to form switchable O/W microemulsions of rapid switching responses. The linear structured superamphiphile was assembled via electrostatic interactions between anionic oleic acid and cationic Jeffamine D-230 at a mole ratio of 1:1. Addition of the CO2 -responsive superamphiphile and 1-butanol as a co-surfactant led to the spontaneous formation of stable heptane-in-water microemulsions. Treating this stable microemulsion with CO2 for 20 s caused dissociation of the superamphiphile into interfacial inactive components, leading to a complete phase separation of the microemulsion into immiscible oil and water phases...
September 11, 2018: Journal of Colloid and Interface Science
Thiago J S Alves, Ana Murcia, Andrea Carolina Wanumen, Valéria Wanderley-Teixeira, Álvaro A C Teixeira, Antonio Ortiz, Pilar Medina
A natural insecticide developed from the mixture of the essential oils (EOs) of Cymbopogon citratus (DC.) Stapf (Poaceae), Cedrus atlantica (Endl.) Manetti ex Carriére (Pinaceae), and Corymbia citriodora (Hook.) K.D. Hill & L.A.S. Johnson (Myrtaceae) was studied. The mixture of oils caused high mortality (LD50 = 0.018 μl/insect) to the Mediterranean fruit fly, Ceratitis capitata (Wiedemann) (Diptera: Tephritidae), a globally important pest, after topical application on adults. Based on the chemical characterization of biopesticide using gas chromatography-mass spectrometry (GC-MS) analysis, many of the constituents had known insecticidal properties (the monoterpenes α-citronellal and E-citral and the sesquiterpernes α-himachalene and β-himachalene, all at concentrations above 15%)...
September 26, 2018: Journal of Economic Entomology
Iwona Patyk, Cezary Rybacki, Agata Kalicka, Agnieszka Rzeszotarska, Jolanta Korsak, Andrzej Chciałowski
Chronic obstructive pulmonary disease (COPD) is a progressive disease underlain by airway inflammation. Despite trials with new generations of anti-inflammatory drugs to alleviate the disease burden, the effective curative treatment remains elusive. In this context, the aim of this study was to assess the influence of simvastatin, a leading member of the family of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, known to display anti-inflammatory and immunomodulatory activity, on symptoms and lung function, as well as the proportion of inflammatory cells, cytokines, proteolytic enzymes, and surfactant protein D (SP-D) content in bronchoalveolar lavage fluid (BALF) in COPD patients...
September 26, 2018: Advances in Experimental Medicine and Biology
Ping Zhang, Sida Ouyang, Peng Li, Zi Gu, Yun Huang, Shuguang Deng
The effects of co-existing anions (NO3 - or SO4 2- ) on the removal of sodium dodecylsulfate (SDS), representing anionic organic pollutants, by Ca-based layered double hydroxide (CaAl-LDH-Cl) are investigated to provide fundamental insights on the ionic surfactant removal in the presence of co-existing anions, and facilitate the establishment of a practical and advanced water treatment for environmental remediation. The SO4 2- system shows higher adsorption capacity (4.43 mmol·g-1 ) and larger d-spacing of adsorption resultant (3...
September 6, 2018: Journal of Colloid and Interface Science
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