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coronary artery disease, arrhythmias

Narut Prasitlumkum, Chanavuth Kanitsoraphan, Veraprapas Kittipibul, Pattara Rattanawong, Pakawat Chongsathidkiet, Wisit Cheungpasitporn
INTRODUCTION: Atrial fibrillation (AF) is the most common arrhythmia, independently associated with significant mortality and morbidity. Recent studies suggest that AF is potentially associated with contrast-induced nephropathy (CIN) in patients with Coronary artery disease (CAD) undergoing catheterization. However, the association was not conclusive. Thus, we assessed the association between AF in patients with CAD and CIN by a systematic review of the literature and a meta-analysis...
October 17, 2018: Clinical Cardiology
Toshiki Takano, Komei Tanaka, Kazuyuki Ozaki, Akinori Sato, Kenichi Iijima, Takao Yanagawa, Daisuke Izumi, Takuya Ozawa, Koichi Fuse, Masahito Sato, Naohito Tanabe, Tohru Minamino
BACKGROUND: The implantable cardioverter defibrillator (ICD) is a standard prevention therapy for patients at high risk for sudden cardiac death (SCD) due to life-threatening ventricular arrhythmia (VA), that is, ventricular fibrillation and ventricular tachycardia. However, clinical predictors of recurrent VA in secondary prevention ICD recipients with coronary artery disease (CAD) remain unknown. Methods and Results: We followed up 96 consecutive patients with CAD undergoing ICD implantation for secondary prevention of SCD...
October 11, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
Thomas R Porter
In a study, published in this issue of Echo Research and Practice, Ntoskas et al. retrospectively analyzed the safety of a cardiac physiologist performing, and interpreting, Dobutamine stress echocardiography (DSE) in of 300 patients undergoing DSE for the detection of inducible reversible ischemia, myocardial viability and valvular heart disease. While safety during the tests themselves did not appear to be compromised with this unsupervised approach, the interpretation of these DSEs causes concerns regarding broad patient safety relative to misread results...
September 1, 2018: Echo Research and Practice
Krzysztof Bartus, Radoslaw Litwinowicz, Jerzy Sadowski, Wojciech Zajdel, Maciej Brzezinski, Magdalena Bartus, Paweł Kleczyński, Stanislaw Bartus, Dhanunjaya Lakkireddy, Boguslaw Kapelak
Introduction: Renal denervation (RD) can lead to a significant and sustained decrease in mean values of arterial blood pressure (BP). However, there is still a subset of patients without a significant BP drop after RD (non-responders). Aim: To compare characteristics of RD responders to RD non-responders and to identify the clinical predictors of BP reduction. Material and methods: Thirty-one patients with diagnosed resistant hypertension underwent RD...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
Aleksandr Voskoboinik, Youlin Koh, Peter M Kistler
Caffeine is the world's most popular 'drug', with tea and coffee a ubiquitous part of daily life. As a psychoactive stimulant, there are potential concerns regarding adverse cardiovascular squeal. Cardiovascular conditions, encompassing hypertension, coronary artery disease, rhythm disorders and heart failure affect billions of patients worldwide. We aim to provide a patient-centered comprehensive review of the cardiovascular effects of caffeinated beverages as they pertain to various common cardiovascular conditions...
October 4, 2018: Trends in Cardiovascular Medicine
L Chevalier, J M Guy, S Doutreleau
Is the stress test still part of the useful examinations in the detection of risk heart disease in sports subjects? Should we continue to use it as a surveillance examination in coronary sports patients? Meta-analysis, considering a ST subshift of more than 1mm as a criterion for positivity, underline the low prevalence of abnormal examinations and a significant rate of false-positives. But for the diagnosis of coronary artery disease, it is mainly the evolution of the ST segment to effort or recovery and the occurrence of stress arrhythmias that detect true positivity...
October 6, 2018: Annales de Cardiologie et D'angéiologie
Perry Wengrofsky, Ghassan Mubarak, Ahmed Shim, Pramod Theetha Kariyanna, Adam Buzidkowski, Jacob Schwartz, Samy I McFarlane
Marijuana abuse is rapidly growing and currently it is the most coimnon drug of abuse in the United States due to increased legalization for recreational and medicinal use. Delta 9-tetrahydrocannibol, the main psychoactive compound in marijuana, acts via the endocannabinoid system to elicit various cardiovascular physiological effects, and has been associated with many adverse cardiovascular effects such as acute coronary syndrome, arrhythmias, and sudden cardiac death that have previously been reported by our group and others...
2018: American journal of medical case reports
M Kwapich, D Lacroix, S Espiard, S Ninni, F Brigadeau, C Kouakam, P Degroote, J M Laurent, V Tiffreau, A Jannin, L Humbert, A Ben Hamou, C Tard, R Ben Yaou, N Lamblin, D Klug, P Richard, C Vigouroux, G Bonne, M C Vantyghem
AIMS: Mutations of the LMNA gene encoding lamin A/C induce heterogeneous phenotypes ranging from cardiopathies and myopathies to lipodystrophies. The aim of this study was to compare cardiometabolic complications in patients with heterozygous LMNA mutations at the 482nd codon, the 'hotspot' for partial lipodystrophy, with carriers of other, non-R482 LMNA mutations. METHODS AND RESULTS: This study included 29 patients with R482 LMNA mutations, 29 carriers of non-R482 LMNA mutation and 19 control subjects...
October 1, 2018: Diabetes & Metabolism
Anna Szajerska-Kurasiewicz, Dorota Lasyk, Danuta Łoboda, Karolina Simionescu, Michał Gibiński, Jolanta Pol-Romik, Krzysztof S Gołba
Obstructive sleep apnea syndrome (OSAS) is caused by periodical upper airway occlusion during sleep resulting in snoring, episodes of apnea and excessive daytime sleepiness. OSAS is a risk factor for hypertension, arrhythmias, conduction disorders as well as stroke, coronary artery disease, chronic heart failure and pulmonary hypertension. Early polygraphy and polysomnography and continuous positive airway pressure (CPAP) treatment reduce risks of cardiovascular diseases (CVD) in patients with OSAS.
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Prashanthi Vemuri, Timothy G Lesnick, Scott A Przybelski, Jonathan Graff-Radford, Robert I Reid, Val J Lowe, Samantha M Zuk, Matthew L Senjem, Christopher G Schwarz, Jeffrey L Gunter, Kejal Kantarci, Mary M Machulda, Michelle M Mielke, Ronald C Petersen, David S Knopman, Clifford R Jack
OBJECTIVE: Recent availability of amyloid and tau PET has provided us with a unique opportunity to measure the association of systemic vascular health with brain health after accounting for the impact of AD pathologies. We wanted to quantify early cerebrovascular health related MRI brain measures (structure, perfusion, microstructural integrity) and evaluate their utility as a biomarker for cerebrovascular health. METHODS: We used two independent samples (Discovery: n= 390; Validation: n=1035) of individuals, aged ≥60 years, along the cognitive continuum with imaging from the population-based sample of Mayo Clinic Study of Aging...
September 28, 2018: Annals of Neurology
Marko Mornar Jelavić, Goran Krstačić, Aleksandra Perenčević, Hrvoje Pintarić
In this article, we outline the latest guidelines published by the American Heart Association on sexual activity in patients with coronary artery disease, heart failure, structural heart diseases, arrhythmias, implanted pacemakers or cardioverter defibrillators, as well as on treatment options of sexual dysfunction. Sexual activities are similar to mild/moderate physical activity during a short period. Most patients are recommended to involve in sexual activity after prior comprehensive evaluation of physical condition...
March 2018: Acta Clinica Croatica
Andrew H Schapiro, Mantosh S Rattan, Ryan A Moore, Jonathan R Dillman
History A 17-year-old white male adolescent was re-evaluated for a withheld cardiac condition initially detected during prenatal imaging at an outside institution. He had previously experienced intermittent episodes of shortness of breath, chest pain, and palpitations with exertion, but more recently he had been asymptomatic. He had no other comorbidities and no family history of congenital heart disease, cardiomyopathy, arrhythmia, or sudden cardiac death. At physical examination, the patient had a grade II/IV rumbling systolic murmur best heard at the left upper sternal border...
October 2018: Radiology
E Samuli Lepojärvi, Heikki V Huikuri, Olli-Pekka Piira, Antti M Kiviniemi, Johanna A Miettinen, Tuomas Kenttä, Olavi Ukkola, Juha S Perkiömäki, Mikko P Tulppo, M Juhani Junttila
AIMS: Biomarkers have shown promising results in risk assessment of cardiovascular events. Their role in predicting the risk of sudden cardiac death (SCD) is not well established. We tested the performance of several biomarkers in risk assessment for SCD in patients with coronary artery disease (CAD) and preserved left ventricular function. METHODS AND RESULTS: The study population consisted of 1,946 CAD patients (68% male; mean age 66.9±8.6 yrs; type 2 diabetes (T2D) 43%) enrolled in the ARTEMIS study...
2018: PloS One
Gary Tse, George Bazoukis, Leonardo Roever, Tong Liu, William K K Wu, Martin C S Wong, Adrian Baranchuk, Panagiotis Korantzopoulos, Dimitrios Asvestas, Konstantinos P Letsas
Tpeak-Tend interval, the time difference between the peak and the end of the T-wave, reflects the degree of dispersion of repolarization. Its prolongation has been associated with higher risks of developing ventricular arrhythmias and sudden cardiac death in different pro-arrhythmic conditions such as Brugada and long QT syndromes. In this review, we will provide a comprehensive overview on how Tpeak-Tend is altered in different atherosclerotic conditions such as hypertension, stable coronary artery disease, acute coronary obstruction, and coronary slow flow as well as inflammatory diseases affecting the arterial tree...
September 17, 2018: Current Atherosclerosis Reports
Fabien Picard, Neila Sayah, Vincent Spagnoli, Julien Adjedj, Olivier Varenne
Vasospastic angina (VSA) is a variant form of angina pectoris, in which angina occurs at rest, with transient electrocardiogram modifications and preserved exercise capacity. VSA can be involved in many clinical scenarios, such as stable angina, sudden cardiac death, acute coronary syndrome, arrhythmia or syncope. Coronary vasospasm is a heterogeneous phenomenon that can occur in patients with or without coronary atherosclerosis, can be focal or diffuse, and can affect epicardial or microvasculature coronary arteries...
September 6, 2018: Archives of Cardiovascular Diseases
William B White, Emad Siddiqui, Tri Tat, Billy Franks, Carol R Schermer
Mirabegron is a β3 -adrenoreceptor agonist used for the treatment of overactive bladder syndrome. We evaluated the cardiovascular (CV) safety of mirabegron using pooled data from 13 studies. The analysis included 13,396 patients who received ≥1 dose of mirabegron (25 mg/50 mg) or comparator antimuscarinics (solifenacin 2.5 mg/5 mg/10 mg or tolterodine extended release 4 mg) as monotherapies, or placebo. We focused on changes in blood pressure and CV adverse events. Baseline CV risk factors had an imbalanced effect on subsequent CV adverse events...
August 10, 2018: Journal of the American Society of Hypertension: JASH
Cédric Villain, Marie Metzger, Christian Combe, Denis Fouque, Luc Frimat, Christian Jacquelinet, Maurice Laville, Serge Briançon, Julie Klein, Joost P Schanstra, Bruce M Robinson, Nicolas Mansencal, Bénédicte Stengel, Ziad A Massy
Background: Although chronic kidney disease (CKD) and age are major risk factors for cardiovascular disease (CVD), little is known about the relative proportions of atheromatous and non-atheromatous CVD by age in CKD patients. Methods: We used baseline data from the French Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort of 3033 patients (65% men) with CKD Stages 3-4 to study crude and adjusted associations between age, the estimated glomerular filtration rate (eGFR), atheromatous CVD (coronary artery disease, peripheral artery disease and stroke) and non-atheromatous CVD (heart failure, cardiac arrhythmia and valvular heart disease)...
August 28, 2018: Nephrology, Dialysis, Transplantation
Foram N Ashar, Rebecca N Mitchell, Christine M Albert, Christopher Newton-Cheh, Jennifer A Brody, Martina Müller-Nurasyid, Anna Moes, Thomas Meitinger, Angel Mak, Heikki Huikuri, M Juhani Junttila, Philippe Goyette, Sara L Pulit, Raha Pazoki, Michael W Tanck, Marieke T Blom, XiaoQing Zhao, Aki S Havulinna, Reza Jabbari, Charlotte Glinge, Vinicius Tragante, Stefan A Escher, Aravinda Chakravarti, Georg Ehret, Josef Coresh, Man Li, Ronald J Prineas, Oscar H Franco, Pui-Yan Kwok, Thomas Lumley, Florence Dumas, Barbara McKnight, Jerome I Rotter, Rozenn N Lemaitre, Susan R Heckbert, Christopher J O'Donnell, Shih-Jen Hwang, Jean-Claude Tardif, Martin VanDenburgh, André G Uitterlinden, Albert Hofman, Bruno H C Stricker, Paul I W de Bakker, Paul W Franks, Jan-Hakan Jansson, Folkert W Asselbergs, Marc K Halushka, Joseph J Maleszewski, Jacob Tfelt-Hansen, Thomas Engstrøm, Veikko Salomaa, Renu Virmani, Frank Kolodgie, Arthur A M Wilde, Hanno L Tan, Connie R Bezzina, Mark Eijgelsheim, John D Rioux, Xavier Jouven, Stefan Kääb, Bruce M Psaty, David S Siscovick, Dan E Arking, Nona Sotoodehnia
Aims: Sudden cardiac arrest (SCA) accounts for 10% of adult mortality in Western populations. We aim to identify potential loci associated with SCA and to identify risk factors causally associated with SCA. Methods and results: We carried out a large genome-wide association study (GWAS) for SCA (n = 3939 cases, 25 989 non-cases) to examine common variation genome-wide and in candidate arrhythmia genes. We also exploited Mendelian randomization (MR) methods using cross-trait multi-variant genetic risk score associations (GRSA) to assess causal relationships of 18 risk factors with SCA...
August 28, 2018: European Heart Journal
L Baumann Kreuziger, K Karkouti, J Tweddell, M P Massicotte
Despite the development of catheter-based interventions for ischemic and valvular heart disease, hundreds of thousands of people undergo open heart surgery annually for coronary artery bypass graft (CABG), valve replacement or cardiac assist device implantation. Cardiac surgery patients are unique because therapeutic anticoagulation is required during cardiopulmonary bypass. Developmental hemostasis and altered drug metabolism affect management in children. This narrative review summarizes the current evidence-based and consensus guidelines regarding perioperative, intraoperative and postoperative antithrombotic therapy in patients undergoing cardiac surgery...
August 28, 2018: Journal of Thrombosis and Haemostasis: JTH
Georges N Kanaan, David A Patten, Calum J Redpath, Mary-Ellen Harper
OBJECTIVES: Type 2 diabetes mellitus is a chronic progressive disease that is associated with increased risk for cardiovascular diseases and with impaired mitochondrial metabolism in cardiac and skeletal muscles. Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with significant morbidity and mortality. Type 2 diabetes is also one of the prevalent concomitant diseases in patients with AF. During AF, myocardial energy demand is high due to electrical activity...
May 31, 2018: Canadian Journal of Diabetes
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