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coronary artery disease, arrhythmias

Rohan M Shah, Qianzi Zhang, Subhasis Chatterjee, Faisal Cheema, Gabriel Loor, Scott A Lemaire, Matthew J Wall, Joseph S Coselli, Todd K Rosengart, Ravi K Ghanta
BACKGROUND: Readmissions adversely affect hospital reimbursement and quality measures. We aimed to evaluate the incidence, cost, and risk factors for readmission following Coronary Artery Bypass Grafting (CABG). METHODS: We queried the National Readmissions Database (NRD) and isolated patients who underwent CABG from 2013-2014. We determined the top reasons for readmission and compared demographics, comorbidities, in-hospital outcomes, and costs between readmitted and non-readmitted patients...
December 13, 2018: Annals of Thoracic Surgery
Ankit B Shah, Mary Z Bechis, Marcel Brown, Jennifer Michaud Finch, Garrett Loomer, Erich Groezinger, Rory B Weiner, Meagan M Wasfy, Michael H Picard, Michael A Fifer, Gregory B Lewis, Aaron L Baggish
KEY POINTS SUMMARY: Intense physical activity, a potent stimulus for sympathetic nervous system activation, is thought to increase the risk of malignant ventricular arrhythmias among patients with hypertrophic cardiomyopathy (HCM). As a result, the majority of patients with HCM deliberately reduce their habitual physical activity after diagnosis and this lifestyle change puts them at risk for sequelae of a sedentary lifestyle; weight gain, hypertension, hyperlipidemia, insulin resistance, coronary artery disease and increased morbidity and mortality...
December 15, 2018: Journal of Physiology
Yihua Bei, Chao Shi, Zhongrong Zhang, Junjie Xiao
As the most populous country worldwide, China has ≈ 290 million patients with cardiovascular diseases (CVDs), representing the leading cause of death in Chinese population. The morbidity and mortality of CVDs are continuously rising. Here, we will first summarize the recent advance in the management of CVDs such as coronary arterial disease, arrhythmia, and heart failure in China. In particular, we will introduce the development of chest pain centers and indicate the novel techniques and methods applied for the management of CVDs...
December 7, 2018: Journal of Cardiovascular Translational Research
Laurel A Grisanti
The prevalence of diabetes is rapidly increasing and closely associated with cardiovascular morbidity and mortality. While the major cardiovascular complication associated with diabetes is coronary artery disease, it is becoming increasingly apparent that diabetes impacts the electrical conduction system in the heart, resulting in atrial fibrillation, and ventricular arrhythmias. The relationship between diabetes and arrhythmias is complex and multifactorial including autonomic dysfunction, atrial and ventricular remodeling and molecular alterations...
2018: Frontiers in Physiology
Aveh Bastani, Erica Su, David H Adler, Christopher Baugh, Jeffrey M Caterino, Carol L Clark, Deborah B Diercks, Judd E Hollander, Susan E Malveau, Bret A Nicks, Daniel K Nishijima, Manish N Shah, Kirk A Stiffler, Alan B Storrow, Scott T Wilber, Annick N Yagapen, Robert E Weiss, Benjamin C Sun
STUDY OBJECTIVE: Controversy remains in regard to the risk of adverse events for patients presenting with syncope compared with near-syncope. The purpose of our study is to describe the difference in outcomes between these groups in a large multicenter cohort of older emergency department (ED) patients. METHODS: From April 28, 2013, to September 21, 2016, we conducted a prospective, observational study across 11 EDs in adults (≥60 years) with syncope or near-syncope...
December 7, 2018: Annals of Emergency Medicine
Glenmore Lasam, Joshua B Oaks
A case of a 51-year-old female with history of hypertension and a significant family history of premature coronary artery disease presented to the hospital after cardiac arrest. She successfully completed a targeted temperature management therapy with full neurologic recovery. Her hospital course was complicated by several bouts of ventricular fibrillation (VF) arrest which was rescued by timely defibrillation, high quality cardiorespiratory resuscitation, and administration of antiarrhythmic medications and inotropic agents...
September 29, 2018: Curēus
Giovanni Peretto, Simone Sala, Giacomo De Luca, Corrado Campochiaro, Silvia Sartorelli, Alberto M Cappelletti, Stefania Rizzo, Anna Palmisano, Antonio Esposito, Alberto Margonato, Moreno Tresoldi, Gaetano Thiene, Cristina Basso, Lorenzo Dagna, Paolo Della Bella
INTRODUCTION: Myocarditis has been described in association with many systemic immune-mediated diseases (SIDs). However, the role of SIDs in influencing clinical presentation and outcome of patients with a new diagnosis of biopsy-proved myocarditis, has never been investigated so far. METHODS: We enrolled 25 consecutive cases with biopsy-proved myocarditis in the context of SIDs, and controls with isolated myocarditis, matched 1:1 by age, gender, ethnicity and clinical presentation...
November 22, 2018: International Journal of Cardiology
Zheng Wei Chen, Chi Sheng Hung, Vin Cent Wu, Yen Hung Lin
As diagnostic techniques have advanced, primary aldosteronism (PA) has emerged as the most common cause of secondary hypertension. The excess of aldosterone caused by PA resulted in not only cardiovascular complications, including coronary artery disease, myocardial infarction, arrhythmia, and heart failure, but also cerebrovascular complications, such as stroke and transient ischemic attack. Moreover, PA is associated more closely with these conditions than is essential hypertension. In this review, we present up-to-date findings on the association between PA and cerebrovascular diseases...
December 2018: Endocrinology and Metabolism
Theodore K Marras, Christopher Vinnard, Quanwu Zhang, Keith Hamilton, Jennifer Adjemian, Gina Eagle, Raymond Zhang, Engels Chou, Kenneth N Olivier
RATIONALE: The risk of all-cause mortality of nontuberculous mycobacterial lung disease (NTMLD) in the United States (US) population is not well established. OBJECTIVES: This study aims to assess the public health burden of NTMLD in the US by comparing the relative risk of all-cause mortality in the NTMLD population with an age- and sex-matched cohort from the general population. METHODS: Patients with physician claims for NTMLD (ICD-9 0.031; ICD-10 A31...
December 2018: Respiratory Medicine
Courtney A Penn, Neil S Kamdar, Daniel M Morgan, Ryan J Spencer, Shitanshu Uppal
OBJECTIVE: Returning home after surgery is a desirable patient-centered outcome associated with decreased costs compared to non-home discharge. Our objective was to develop a preoperative risk-scoring model predicting non-home discharge after surgery for gynecologic malignancy. METHODS: Women who underwent surgery involving hysterectomy for gynecologic malignancy from 2013 to 2015 were identified from the Michigan Surgical Quality Collaborative database. Patients were divided by discharge destination, and a multivariable logistic regression model was developed to create a nomogram to assign case-specific risk scores...
November 26, 2018: Gynecologic Oncology
Murat Akcay
INTRODUCTION: Long-time exposure to high altitude leads to changing at the respiratory, cardiovascular and hematological systems. There is no sufficient study about cardiovascular changes in moderate altitude. The distance between the peak and the end of the T wave (Tp-e) is a measure of transmyocardial distribution of repolarization and may be associated to dangerous rhythm disorders and ventricular arrhythmias. Again, P-wave dispersion (PWD) described as the extension of interatrial and intraatrial conduction time and inhomogeneous spread of sinus pulses are well recognized electrophysiologic features in patients with atrial fibrillation...
November 2018: Journal of Electrocardiology
Dorota Kokosińska, Jan Jakub Gierałtowski, Jan Jacek Żebrowski, Ewa Orłowska-Baranowska, Rafał Baranowski
OBJECTIVE: Both the central nervous system and the autonomic nervous system are complex physiological networks which modulate the heart rate. They are spatially extended, have built-in delays and work on many time scales simultaneously-nonhomogeneous networks with multifractal dynamics. The object of our research was the analysis of human heart rate variability (HRV) using the nonlinear multiscale multifractal analysis (MMA) method for several cardiovascular diseases. The analysis of HRV (night-time recordings) involved six groups of patients: 61 healthy persons, 104 cases with aortic valve stenosis, 42 with hypertrophic cardiomyopathy, 36 with atrial fibrillation, 70 patients with coronary artery disease and 19 with congestive heart failure...
November 28, 2018: Physiological Measurement
Maria García-Alvarez, Vicente Climent
Acromegaly is a rare disease characterized by high levels of growth hormone (GH) and insulin- like growth factor 1 (IGF-1). The excess of GH leads to the development of different manifestations in different organs, from subtle signs in the bones and soft tissues to the development of respiratory and cardiac insufficiency. In the cardiovascular system, the GH/IGF-1 axis exerts its influence on three major aspects: myocyte growth and structure, cardiac contractility and vascular function. In this article, we review the different cardiovascular and respiratory complications as well as the effects of the different treatments on these complications...
November 26, 2018: Minerva Endocrinologica
Edward T Ha, Michael L Weinrauch, Jeffrey Brensilver
Currently, the cardiovascular risk associated with the use of anabolic steroids is not well documented. Recent studies have shown that its use may potentiate the development of cardiac dysfunction in the short term. This case report describes an encounter that supports a causal link between anabolic-androgenic steroid use (AAS) and cardiomyopathy later in life. We herein present a case study of a 73-year-old prior Olympic athlete who had misused AAS for 20 years and subsequently was found to have developed a systolic and diastolic cardiomyopathy, presumably due to long-standing left ventricular hypertrophy...
September 17, 2018: Curēus
Haqeel A Jamil, Sajeel A Mohammed, John Gierula, Maria F Paton, Judith E Lowry, Richard M Cubbon, Mark T Kearney, Klaus K A Witte
Symptomatic sustained ventricular tachycardia is a life threatening arrhythmia requiring prompt treatment. However, the risk associated with asymptomatic nonsustained ventricular tachycardia (NSVT) detected on routine permanent pacemaker (PPM) interrogation in patients with known cardiac conduction disease is unknown. Our aim is to determine if asymptomatic NSVT detected on PPM interrogation is associated with increased mortality. As part of a prospective observational cohort study, 582 patients with long-term pacemakers were recruited at a tertiary cardiac centre, and followed for 4 ± 1...
November 7, 2018: American Journal of Cardiology
Ewa Hryniewiecka, Jolanta Żegarska, Dorota Żochowska, Emilia Samborowska, Radosław Jaźwiec, Maciej Kosieradzki, Sławomir Nazarewski, Michał Dadlez, Leszek Pączek
Cardiovascular disease (CVD) remains one of the primary causes of death after kidney transplantation (KTX). Cyclosporine (CsA) metabolites may play a role in CVD. Metabolic ratio (MR) may be considered a measure of intra-individual differences of CsA metabolism. The study was aimed at analysis of associations of CVD with indices of CsA metabolism: MRs and dose-adjusted CsA concentrations (C/D and C/D/kg). The study was performed in the Department of Immunology, Transplant Medicine, and Internal Diseases of the Medical University of Warsaw and involved 102 KTX recipients...
November 23, 2018: Cardiovascular Toxicology
Elton Amp Dudink, Barend W Florijn, Bob Weijs, Jacques Mgj Duijs, Justin Glm Luermans, Frederique Ecm Peeters, Leon J Schurgers, Joachim E Wildberger, Uli Schotten, Roel Bijkerk, Harry Jgm Crijns, Anton Jan van Zonneveld
Background Atrial fibrillation (AF) in patients without concomitant cardiovascular pathophysiological disease, is called idiopathic atrial fibrillation (iAF). Nonetheless, iAF patients have oftentimes subclinical coronary (micro)vascular dysfunction and, particularly in women, a higher prevalence of subsequent cardiovascular comorbidities. Previously, we identified a plasma miRNA association with diabetes and microvascular injury in diabetic nephropathy (DN) patients. Therefore, in this study we assessed whether plasma levels of these diabetic, microvascular injury associated miRNAs reflect microvascular integrity in iAF patients, associate with the presence of paroxysmal arrhythmia or instead are determined by concealed coronary artery disease...
November 22, 2018: MicroRNA
Yuliya Krokhaleva, Marmar Vaseghi
Sudden cardiac arrest is the leading cause of cardiovascular mortality, posing a substantial public health burden. The incidence and epidemiology of sudden death are a function of age, with primary arrhythmia syndromes and inherited cardiomyopathies representing the predominant causes in younger patients, while coronary artery disease being the leading etiology in those who are 35 years of age and older. Internal cardioverter defibrillators remain the mainstay of primary and secondary prevention of sudden cardiac arrest...
November 6, 2018: Trends in Cardiovascular Medicine
Douglas Robinson, Gregory Hand, Jason Ausman, Anthony Hackett
BACKGROUND: Brugada pattern is a well-known pathological finding on electrocardiogram (ECG) which increases the likelihood of cardiac arrest due to ventricular arrhythmia. These cases generally present in younger patients without evidence of an electrolyte abnormality, structural heart disease, or cardiac ischemia. In many instances, this pattern is either hidden on initial presentation or presents as an incidental finding on an EKG. Often times the Brugada syndrome leads to sudden cardiac death or more rarely can be unmasked with a class 1A or 1C anti-arrhythmic agent...
October 23, 2018: American Journal of Emergency Medicine
Eleonora Tobaldini, Elisa M Fiorelli, Monica Solbiati, Giorgio Costantino, Lino Nobili, Nicola Montano
Short sleep duration has a substantial influence on the overall health of an individual. Short sleep time can be a consequence of lifestyle habits, environmental factors, or the presence of a sleep disorder, such as insomnia or sleep-disordered breathing. Short sleep time is associated with increased morbidity and mortality, mainly from cardiovascular disorders (including coronary artery disease, arrhythmias, and hypertension). Several biological mechanisms have been proposed as a possible link between short sleep duration and these diseases, such as involvement of the autonomic nervous system, endothelial function, metabolic regulation, inflammation, and the coagulation system...
November 8, 2018: Nature Reviews. Cardiology
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