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https://www.readbyqxmd.com/read/30517715/validation-of-new-potential-targets-for-remission-and-low-disease-activity-in-psoriatic-arthritis-in-patients-treated-with-golimumab
#1
Laura C Coates, Proton Rahman, Eliofotisti Psaradellis, Emmanouil Rampakakis, Brendan Osborne, Allen J Lehman, Francois Nantel
Objectives: Treat to target recommendations for PsA state that the target of treatment should be remission or, at the very least, low disease activity. Different clinical indexes have been proposed to define these disease states including the minimal disease activity criteria and the Disease Activity Index for PsA (DAPSA) scores, which have 7 and 4-5 domains, respectively. Using a Canadian cohort, the objectives were to calculate the proportion of patients achieving these criteria, their prognostic value and the overall patient impact of these disease states...
December 4, 2018: Rheumatology
https://www.readbyqxmd.com/read/30514330/soft-tissue-restrictors-of-femoral-elevation-in-direct-anterior-approach-an-anatomic-study
#2
Gongyin Zhao, Ruixia Zhu, Shijie Jiang, Chao Xu, Nanwei Xu, Yuji Wang
BACKGROUND: With the patient in a constant supine position, elevation of the femur in THA (DAA) provides a more intuitive and conducive location of the acetabulum for the correct placement of the acetabular prosthesis, but elevation of the femur for broaching becomes more challenging. The purpose of this study is to analyze the restriction of the ischiofemoral ligament and short external rotation muscles, and its effect on the elevation of the proximal femur in the DAA. METHODS: The study subjects comprised 5 freshly frozen cadavers with 10 normal hips...
December 4, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/30509621/influence-of-hip-center-position-anterior-inferior-iliac-spine-morphology-and-ball-head-diameter-on-range-of-motion-in-total-hip-arthroplasty
#3
Tomonori Tabata, Nobuhiro Kaku, Hiroaki Tagomori, Hiroshi Tsumura
BACKGROUND: Acetabular component orientation, such as high placement and femoral head diameter influence joint stability in total hip arthroplasty (THA), wherein anterior inferior iliac spine (AIIS) shape could cause femoro-acetabular impingement. Little is known regarding the combined influence of these parameters, particularly in the context of developmental dysplasia of the hip. Therefore we conducted a computer simulation study based on computed tomography (CT) data to determine whether: (1) AIIS shape, (2) high placement of acetabular cups, and (3) ball head diameter influence the range of motion (ROM) after THA...
November 30, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/30507725/does-the-clinical-phenotype-of-mucolipidosis-iii%C3%AE-differ-from-its-%C3%AE-%C3%AE-counterpart-supporting-facts-in-a-cohort-of-18-patients
#4
Sheela Nampoothiri, Nursel H Elcioglu, Suleyman S Koca, Dhanya Yesodharan, Chandrababu Kk, Vinod Krishnan, Meenakshi Bhat, Mohandas Nair K, Natasha Radhakrishnan, Mahesh Kappanayil, Jayesh J Sheth, Sandra Alves, Francisca Coutinho, Michael J Friez, Richard M Pauli, Sheila Unger, Andrea Superti-Furga, Jules G Leroy, Sara S Cathey
Mucolipidosis-IIIγ (ML-IIIγ) is a recessively inherited slowly progressive skeletal dysplasia caused by mutations in GNPTG. We report the genetic and clinical findings in the largest cohort with ML-IIIγ so far: 18 affected individuals from 12 families including 12 patients from India, five from Turkey, and one from the USA. With consanguinity confirmed in eight of 12 families, molecular characterization showed that all affected patients had homozygous pathogenic GNPTG genotypes, underscoring the rarity of the disorder...
January 2019: Clinical Dysmorphology
https://www.readbyqxmd.com/read/30507513/batch-mode-query-by-committee-for-motor-imagery-based-bci
#5
Ibrahim Hossain, Abbas Khosravi, Imali Hettiarachchi, Saeid Nahavandi
Although brain-computer interface (BCI) has potential application in the rehabilitation of neural disease and performance improvement of the human in the loop system, it is restricted in the laboratory environment. One of the hindrances behind this restriction is the requirement of a long training data collection session for the user prior to operation of the system at each time. Several approaches have been proposed including the reduction of training data maintaining the robust performance. One of them is active learning (AL) which asks for labeling the training samples and it has the potential to reach robust performance using reduced informative training set...
November 28, 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/30506108/low-level-laser-therapy-prevents-treadmill-exercise-induced-progression-of-arthrogenic-joint-contracture-via-attenuation-of-inflammation-and-fibrosis-in-remobilized-rat-knees
#6
Akinori Kaneguchi, Junya Ozawa, Kengo Minamimoto, Kaoru Yamaoka
We investigated whether the combination of exercise and anti-inflammatory/anti-fibrotic treatment using low-level laser therapy (LLLT) promotes recovery from joint contracture without arthrogenic contracture progression. Rat knees were immobilized for 3 weeks in a flexed position. After fixator removal, rats were divided into no intervention (RM), daily treadmill walking (WALK), and daily treadmill walking and LLLT (W + L) groups. Total and arthrogenic contractures were assessed by restrictions of passive range of motion (ROM) before (m-ROM) and after myotomy (a-ROM), respectively...
December 1, 2018: Inflammation
https://www.readbyqxmd.com/read/30500361/the-neurophysiology-of-deforming-spastic-paresis-a-revised-taxonomy
#7
REVIEW
Marjolaine Baude, Jens Bo Nielsen, Jean-Michel Gracies
This paper revisits the taxonomy of the neurophysiological consequences of a persistent impairment of motor command execution in the classic environment of sensorimotor restriction and muscle hypo-mobilization in short position. Around each joint, the syndrome involves 2 disorders, muscular and neurologic. The muscular disorder is promoted by muscle hypo-mobilization in short position in the context of paresis, in the hours and days after paresis onset: this genetically mediated, evolving myopathy, is called spastic myopathy...
November 28, 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/30498632/reproduction-and-metamorphosis-in-the-myristica-swamp-tree-frog-mercurana-myristicapalustris-anura-rhacophoridae
#8
Robin Kurian Abraham, Jobin Kuruvilla Mathew, David Valiaparampil Raju, Ramprasad Rao, Anil Zachariah
The reproductive biology of the Myristica Swamp tree frog ( Mercurana myristicapalustris ), a monotypic rhacophorid frog endemic to the foothills of the Western Ghats mountains of India, has remained unknown since the description of the genus and species. We monitored individuals from parental generation amplexus to the completion of offspring generation tadpole metamorphosis. Surprisingly, our observations revealed that this species exhibits many previously unknown characteristics, including the first ever record of the female, and a diverse call repertoire, consisting of five different call types (the functions of which remain incompletely known)...
2018: PeerJ
https://www.readbyqxmd.com/read/30498368/pena-shokeir-syndrome-current-management-strategies-and-palliative-care
#9
REVIEW
Sumaiya Adam, Melantha Coetzee, Engela Magdalena Honey
Pena-Shokeir syndrome (PSS) type 1, also known as fetal akinesia deformation sequence, is a rare genetic syndrome that almost always results in intrauterine or early neonatal death. It is characterized by markedly decreased fetal movements, intrauterine growth restriction, joint contractures, short umbilical cord, and features of pulmonary hypoplasia. Antenatal diagnosis can be difficult. Ultrasound features are varied and may overlap with those of Trisomy 18. The poor prognosis of PSS is due to pulmonary hypoplasia, which is an important feature that distinguishes PSS from arthrogryposis multiplex congenital without pulmonary hypoplasia, which has a better prognosis...
2018: Application of Clinical Genetics
https://www.readbyqxmd.com/read/30482738/is-infrared-thermography-effective-in-the-diagnosis-of-temporomandibular-disorders-a-systematic-review
#10
REVIEW
Daniela Pita de Melo, Patrícia Meira Bento, Larissa Rangel Peixoto, Sheyla Kátia Lúcio Dornelas Martins, Carolina Castro Martins
OBJECTIVE: The aim of this study was to systematically review the scientific efficacy of infrared thermography (IT) on the diagnosis of temporomandibular joint disorders (TMDs). STUDY DESIGN: An electronic search was performed in 8 databases for publications up to May 2018. Additionally, a hand search of the reference lists was conducted. There were no restrictions on language or on year of publication. Two independent reviewers selected the studies, reviewed the abstract information, and assessed the quality...
September 26, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/30481496/donor-site-morbidity-after-osteocutaneous-free-fibula-transfer-longitudinal-analysis-of-gait-performance
#11
Riccardo Di Giuli, Matteo Zago, Giada A Beltramini, Maria Ludovica Pallotta, Alessandro Bolzoni, Alessandro Baj, Aldo Bruno Giannì, Chiarella Sforza
PURPOSE: The purpose was to evaluate donor-site clinical morbidity and changes in kinematic gait parameters after the harvest of a vascularized free fibula flap for facial reconstruction. MATERIALS AND METHODS: We enrolled 14 patients (aged 50 ± 15 years) in a longitudinal study. Every patient underwent a double evaluation in which a presurgical assessment and 6-month postsurgical assessment were performed. Subjective donor-site evaluation was carried out through unstructured clinical questioning about pain, paresthesia, walking ability, and restrictions in activity...
November 2, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30480764/corticosteroids-for-septic-arthritis-in-children
#12
REVIEW
Mario F Delgado-Noguera, Jessica M Forero Delgadillo, Alexis A Franco, Juan C Vazquez, Jose Andres Calvache
BACKGROUND: Septic arthritis is an acute infection of the joints characterised by erosive disruption of the articular space. It is the most common non-degenerative articular disease in developing countries. The most vulnerable population for septic arthritis includes infants and preschoolers, especially boys. Septic arthritis disproportionately affects populations of low socioeconomic status. Systemic corticosteroids and antibiotic therapy may be beneficial for treatment of septic arthritis...
November 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30479667/validation-of-a-weight-bearing-ankle-equinus-value-in-older-adults-with-diabetes
#13
A Searle MOsteo, M J Spink, V H Chuter
Background: Accurate measurement of ankle joint dorsiflexion is clinically important as a restriction has been linked to many foot and ankle pathologies, as well as increased ulcer risk and delayed ulcer healing in people with diabetes. Use of the reliable weight bearing (WB) Lunge test is limited as normal and restricted ranges for WB ankle joint dorsiflexion are not identified. Additionally the extent of WB dorsiflexion restriction that results in clinically adverse outcomes is unclear...
2018: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/30478780/-performance-control-after-arthroscopic-arthrolysis-with-capsulectomy-in-fresh-frozen-elbow-joints
#14
R Nietschke, M M Schneider, B Hollinger, T Buder, A Zimmerer, F Zimmermann, K J Burkhart
BACKGROUND AND OBJECTIVE: Posttraumatic or postoperative movement restrictions in elbow joints can often occur (including capsular contracture) and can generate everyday limitations. In persistent elbow stiffness, arthroscopic arthrolysis with removal of the dorsal and ventral capsule portions can be carried out. The purpose of this study was to assess the efficacy of arthroscopic capsulectomy by means of an in vitro anatomical study. METHODS: A standardized elbow arthroscopy with ventral and dorsal capsulectomy was performed and image-documented in five fresh-frozen elbow specimens...
November 26, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/30478635/-acute-injury-of-the-posterior-cruciate-ligament-with-femoral-avulsion-arthroscopic-ligament-repair-and-bracing
#15
REVIEW
A Achtnich, A Schmitt, P Forkel, A B Imhoff, K Beitzel
OBJECTIVE: The aim of arthroscopic bracing of the posterior cruciate ligament (PCL) is to restore anatomic and biomechanic function in acute PCL tears. Therefore, primary augmentation of the PCL by using a stable suturing system is used. INDICATIONS: Acute tears of the PCL, femoral avulsions, isolated or combined in cases of multiligament injuries (knee dislocations of Schenk types II-IV). CONTRAINDICATIONS: Chronic instabilities of the PCL, infection of the knee joint...
November 26, 2018: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/30473845/vertebral-morphometrics-and-lung-structure-in-non-avian-dinosaurs
#16
Robert J Brocklehurst, Emma R Schachner, William I Sellers
The lung-air sac system of modern birds is unique among vertebrates. However, debate surrounds whether an avian-style lung is restricted to birds or first appeared in their dinosaurian ancestors, as common osteological correlates for the respiratory system offer limited information on the lungs themselves. Here, we shed light on these issues by using axial morphology as a direct osteological correlate of lung structure, and quantifying vertebral shape using geometric morphometrics in birds, crocodilians and a wide range of dinosaurian taxa...
October 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/30471785/polymerase-chain-reaction-assay-using-the-restriction-fragment-length-polymorphism-technique-in-the-detection-of-prosthetic-joint-infections-a-multi-centered-study
#17
Ataollah Moshirabadi, Mohammad Razi, Peyman Arasteh, Mohammad Mahdi Sarzaeem, Saman Ghaffari, Saied Aminiafshar, Kami Hosseinian Khosroshahy, Fatemeh Maryam Sheikholeslami
BACKGROUND: PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) techniques have been used for the diagnosis of bacteria in some infections. In this study, we aimed to evaluate the diagnostic accuracy of PCR for the diagnosis of prosthetic joint infections (PJI) and to identify isolated microorganisms, using the RFLP method. METHODS: During January 2015 to January 2018, patients who were suspected of having PJI after arthroplasty surgery or were candidates for revision surgery due to loosening of implant entered the study...
October 25, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/30471756/expanded-genome-wide-association-study-meta-analysis-of-psoriasis-expands-the-catalog-of-common-psoriasis-associated-variants
#18
James T Elder
Psoriasis is a complex immune-mediated disease of skin and joints with a prevalence of about 2%. Previous genetic association studies have identified more than 60 psoriasis susceptibility loci, 47 of which were identified in Caucasians. To further understand the genetic architecture of this disease, we conducted the largest meta-analysis of genome-wide association studies (GWAS) for psoriasis to date, including data from eight different Caucasian cohorts (seven GWAS and one Immunochip dataset), with a combined effective sample size of more than 39,000 individuals...
December 2018: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/30470233/on-the-unraveling-of-revitalization-of-local-health-traditions-in-india-an-ethnographic-inquiry
#19
Arima Mishra, Devaki Nambiar
BACKGROUND: India has recently renewed emphasis on non-allopathic systems of medicine as a means to address the health needs of its populace. Earlier in 2002, its national health policy had sought to 'revitalize' community-based health knowledge and practices - jointly christened 'local health traditions'. Yet policy texts remain silent on the actual means by which 'revitalization of local health traditions' should take place. Our research sought to understand the policy lessons of and for revitalization of local health traditions in the three Southern Indian states through an ethnographic inquiry in 2014-2016...
November 23, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/30470217/disseminated-learning-from-clinician-scientists-a-multiple-case-study-in-physiotherapeutic-care
#20
Esther E van Dijk, Manon Kluijtmans, Jonne P Vulperhorst, Sanne F Akkerman
BACKGROUND: Clinician-Scientists are considered to be important for continuous improvement of patient care, because they are ideally positioned to bridge the gap between scientific research and clinical care. However, limited empirical evidence is available about how they connect these two realms. So far research has mainly focused on their direct role in bridging the gap. This study investigates an additional mechanism; that is whether clinician-scientists also connect science and care indirectly through disseminated learning...
November 23, 2018: BMC Medical Education
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