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Keiko Aida-Yasuoka, Noriko Nishimura, Nozomi Fujisawa, Nozomi Endo, Shuh Narumiya, Chiharu Tohyama
Prostaglandin E2 (PGE2 ) is a critical factor in the pathogenesis of dioxin-induced neonatal hydronephrosis. Since the PGE2 receptor has four subtypes, EP1 - EP4, this study was aimed to challenge the hypothesis that at least one of the four subtypes is responsible for the pathogenesis of dioxin-induced hydronephrosis. To this end, we used mouse pups, with a C57BL/6 J background, genetically lacking EP1, EP2, or EP3, and wild-type pups in whom EP4 was suppressed by administering ONO-AE3-208 (ONO), an EP4 antagonist, from postnatal day 1 (PND 1) to PND 13...
January 11, 2019: Toxicology
Kang-Yi Su, Ming-Chieh Li, Nian-Wei Lee, Bing-Ching Ho, Chiou-Ling Cheng, Yu-Chen Chuang, Sung-Liang Yu, Yue Leon Guo
Epigenome-wide DNA methylation has not been studied in men perinatally exposed to PCBs and dioxins. Therefore, we examined whether perinatal exposure to polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) induces sustained methylation changes lasting to early adulthood. We used the Illumina HumanMethylation450 BeadChip to assess DNA methylation in whole blood among Yucheng second generation (people perinatal exposed to high PCBs and PCDFs) compared with referents. Thirty male offspring from the Yucheng cohort were randomly selected and matched with 30 male offspring from the Yucheng' neighborhood referents with similar backgrounds...
January 3, 2019: Environmental Research
Jennifer Ames, Marcella Warner, Claudia Siracusa, Stefano Signorini, Paolo Brambilla, Paolo Mocarelli, Brenda Eskenazi
BACKGROUND: Prenatal 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure has been shown to alter sexual differentiation of the brain in animal models, impacting pubertal development, behavior, cortical dominance, and cognition. The effects of early life exposure to dioxin-like compounds on human neurodevelopment, however, are less clear and warrant further investigation. METHODS: The Seveso Women's Health Study (SWHS), initiated in 1996, is a well-characterized cohort of 981 Italian women who lived in proximity to an industrial accident in July 1976 that resulted in one of the highest residential TCDD exposures on record...
January 9, 2019: International Journal of Hygiene and Environmental Health
M H B Müller, A Polder, O B Brynildsrud, R Grønnestad, M Karimi, E Lie, W B Manyilizu, R H Mdegela, F Mokiti, M Murtadha, H E Nonga, J U Skaare, A Solhaug, J L Lyche
Human exposure to persistent organic pollutants (POPs) begins during pregnancy and may cause adverse health effects in the fetus or later in life. The present study aimed to assess prenatal POPs exposure to Tanzanian infants and evaluate the distribution of POPs between breast milk, maternal blood, placenta and cord blood. For assessment of prenatal exposure, 48 maternal blood samples from Mount Meru Regional Referral Hospital (MMRRH), Arusha Tanzania, were analyzed for organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), brominated flame retardants (BFRs), dioxin-like (DL) activity and perfluorinated alkyl substances (PFASs)...
December 18, 2018: Environmental Research
Basilua Andre Muzembo, Miyuki Iwai-Shimada, Tomohiko Isobe, Kokichi Arisawa, Masayuki Shima, Tetsuhito Fukushima, Shoji F Nakayama
BACKGROUND: Over the past few decades, the Japanese Ministry of the Environment has been biomonitoring dioxins in the general Japanese population and, in response to public concerns, has taken measures to reduce dioxin exposure. The objectives of this study were to assess the current dioxin dietary intake and corresponding body burden in the Japanese and compare Japanese dioxin data from 2011 to 2016 and 2002-2010 surveys. We also examined the relationship between blood dioxins and health parameters/clinical biomarkers...
January 10, 2019: Environmental Health and Preventive Medicine
Mei-Hui Ren, Yun Fan, Sheng Wang, Liang Xu, Ning Zhang, Xue-Ping Zhang, Ji-Ping Chen, Hai-Jun Zhang
The removal efficiencies of typical unintentionally produced persistent organic pollutants (UP-POPs) from flues gases from coke gas burning were obtained using selective catalytic reduction (SCR) equipment installed in a large coking plant. The total congeners of polychlorinated dibenzo- p -dioxins/dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), and polychlorinated naphthalenes (PCNs) in the flue gases at the inlet and outlet of the SCR equipment and the dustfall were analyzed. The results show that the removal efficiency of the total PCDD/Fs was the highest (94...
January 8, 2019: Huan Jing Ke Xue= Huanjing Kexue
Chao-Heng Tseng, Ling-Ling Chen, Po-Chun Yeh
Mercury and dioxin pollution associated with the China Petrochemical Development Corporation's An-shun plant is one of the most severe soil contamination incidents in Taiwan's history. Residents living nearby were exposed to heavy metals and dioxins that led to significant impacts on human health and safety. While many studies related to contamination in large-scale industrial areas have been conducted to evaluate the effects of occupational contaminant exposure, studies related to people who live near small-scale industry areas are less common...
December 2018: Heliyon
Carla Reale, Filomena Russo, Sara Carmela Credendino, Danila Cuomo, Gabriella De Vita, Massimo Mallardo, Francesca Pennino, Immacolata Porreca, Maria Triassi, Mario De Felice, Concetta Ambrosino
Epidemiological and experimental studies emphasize the link between environmental chemicals exposure and thyroid cancer. However, this association is strongly debated and the mechanisms of action of environmental thyroid carcinogens still need to be identified. The analysis of in vitro transcriptomic data developed to investigate the effects of chlorpyrifos on immortalized thyrocytes highlighted the impaired expression of genes involved in endodermal carcinogenesis. This endodermal carcinogenic gene-network (ECGN, including Zfp36l2 , Dmbt1 , Ddit4 ), was validated in cellular and mouse models of thyroid carcinogenesis, characterized by the constitutive activation of the mitogen-activated protein kinase (MAPK) pathway and in immortalized thyrocytes exposed to tetrachlorodibenzo- p -dioxin (TCDD) and chlorpyrifos (CPF)...
January 4, 2019: International Journal of Environmental Research and Public Health
Jessica A Head, Sean W Kennedy
Exposure to dioxin-like compounds (DLCs) is consistently associated with concentration-dependent induction of cytochrome P4501A (CYP1A) enzymes in primary cultures of avian hepatocytes. We have previously demonstrated that the median effective concentration (EC50) for induction of this response is predictive of in vivo sensitivity to dioxin-like compounds in birds. Here we investigate sources of interindividual variation in the CYP1A response to TCDD in wild herring gulls, and consider how this variation may complicate dioxin sensitivity estimates based on the CYP1A bioassay...
January 7, 2019: Environmental Toxicology and Chemistry
Mohammed A Khairy, Gregory O Noonan, Rainer Lohmann
The bioavailability and bioaccumulation of sedimentary hydrophobic organic compounds (HOCs) is of concern at contaminated sites. Passive samplers have emerged as a promising tool to measure the bioavailability of sedimentary HOCs and possibly to estimate their bioaccumulation. We thus analyzed HOCs including organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) in sediment, porewater and riverwater using low density polyethylene (LDPE) passive samplers, and in 11 different finfish species and blue crab from the lower Passaic River...
January 5, 2019: Environmental Toxicology and Chemistry
Yu Shang, Meiying Wu, Jizhi Zhou, Xing Zhang, Yufang Zhong, Jing An, Guangren Qian
Fine particles (PM2.5 ) emitted from municipal solid waste incineration (MSWI) contain high amounts of toxic compounds and pose a serious threat to environment and human health. In this study, entire particles as well as extracted water-soluble and -insoluble fractions of PM2.5 collected from MSWI and biomass incineration (BMI) were subjected to physiochemical characterization and cytotoxic tests in A549 and BEAS-2B cells. MSWI PM2.5 had higher contents of heavy metals (including Pb, Zn, and Cu) and dioxins (PCDD/Fs) than did BMI PM2...
December 18, 2018: Journal of Hazardous Materials
Eun-Young Kim, Naomi Inoue, Dong-Hee Koh, Hisato Iwata
To understand the role of aryl hydrocarbon receptor (AHR) isoforms in avian species, we investigated the functional characteristics of two AHR isoforms (designated as jcAHR1 and jcAHR2) of the jungle crow (Corvus macrorhynchos). Two amino acid residues corresponding to Ile324 and Ser380 (high sensitive type) in chicken AHR1 that are known to determine dioxin sensitivity were Ile325 and Ala381 (moderate sensitive type) in jcAHR1 and Val306 and Ala362 (low sensitive type) in jcAHR2. The quantitative comparison of the two jcAHR mRNA expression levels in a Tokyo jungle crow population showed that jcAHR2 accounted for 92...
December 28, 2018: Ecotoxicology and Environmental Safety
Jose R Suarez-Lopez, Chase G Clemesha, Miquel Porta, Myron D Gross, Duk-Hee Lee
BACKGROUND: Some evidence in humans suggests that persistent organic pollutants (POPs), including organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), may alter the blood lipid composition. This study analyzed associations between serum POPs concentrations in young adulthood with blood lipid levels up to 23 years later. METHODS: Serum POPs were measured in year 2 of follow-up (n = 180 men and women, ages: 20-32y), and plasma lipids in follow-up years 2, 7, 10, 15, 20 and 25...
December 23, 2018: Environmental Toxicology and Pharmacology
Jian-Lin Wu, Fenfen Ji, Hongna Zhang, Chuanqin Hu, Ming Hung Wong, Di Hu, Zongwei Cai
Triclosan, a widely used antimicrobial agent, can increase colitis-associated colon tumorigenesis, and induce liver fibrosis and cancer in mice through mechanisms which may be relevant in humans. In this study, an analytical method using gas chromatography-mass spectrometry (GC-MS) and high resolution gas chromatography-high resolution mass spectrometry (HRGC-HRMS) was developed to measure dioxins and chlorinated derivatives from triclosan in the presence of active chlorine in seawater matrix. Formation yields of dioxins and chlorinated triclosans were assessed at different initial precursor concentrations under dark and UV light irradiation conditions...
December 23, 2018: Journal of Hazardous Materials
Cunwei Liu, Rong Guo, Wei Wang, Xiaocong Liang, Yuanjie Lin, Sunyang Yue, Dasheng Lu
OBJECTIVE: To investigate the pollution level of dioxin-like compounds in animal-derived foods from 10 cities of Shaanxi Province. METHODS: Collect four representative food samples( pork, beef, fish and eggs) to determine the concentrations of29 types of dioxin-like compounds by high-resolution gas chromatographs/high-resolution mass spectrometers( HRGC-HRMS). RESULTS: The result showed that the toxic equivalent quantity( TEQ) value of dioxin-like compounds in fish was 0...
November 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
Siwatt Pongpiachan, Teeraporn Wiriwutikorn, Phonethip Phetsomphou, Kwanchai Jieam, Khammanithip Vongxay, Ken Choviran, Andrea Sbrilli, Massimo Gobbi, Carmela Centeno
Polychlorinated-dibenzo-para-dioxins (PCDDs) and Polychlorinated-dibenzofurans (PCDFs) contamination in ecosystems has been a major concern, however, no information is available about the atmospheric contents and emission profiles in different types of fuels from industrial boilers in Thailand, Lao PDR, and Cambodia. Nine air and bottom ash samples ( n = 18) were collected from three industrial boilers using U.S.EPA Method 23 and U.S.EPA Method 8290, respectively. All samples were successfully quantified by two High Resolution Chromatography-High Resolution Mass Spectrometry (HRGC-HRMS) namely Waters Autospec Premier and Waters Autospec Ultima...
February 2019: Data in Brief
Yixi Zhou, Chao Shen, Hong Du, Yuanyuan Bao, Chengyong He, Chonggang Wang, Zhenghong Zuo
Currently used pesticides are widely distributed in surface water. Most of them are harmful to aquatic animals. In the present study, a novel recombinant hepatic cell line was developed for detecting the activity of aryl hydrocarbon receptor (AhR) agonists, and their potential bio-toxicity to aquatic animals was evaluated. First, HepG2 cells were stably transfected with a luciferase reporter plasmid containing a zebrafish (Danio rerio) cyp1a1 promoter with twelve copies of dioxin-responsive elements. The minimal detection limit was a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) concentration of 0...
December 17, 2018: Chemosphere
Chelsea A O'Driscoll, Joshua D Mezrich
This review examines the current literature on the effects of atmospheric particulate matter (PM) on autoimmune disease and proposes a new role for the aryl hydrocarbon receptor (AHR) as a modulator of T cells in PM-mediated autoimmune disease. There is a significant body of literature regarding the strong epidemiologic correlations between PM exposures and worsened autoimmune diseases. Genetic predispositions account for 30% of all autoimmune disease leaving environmental factors as major contributors. Increases in incidence and prevalence of autoimmune disease have occurred concurrently with an increase in air pollution...
2018: Frontiers in Immunology
Ping Chen, Wenwen Gong, Gang Yu, Heidelore Fiedler
This research presents release inventories of unintentionally generated dioxin-like polychlorinated biphenyls (dl-PCB) and hexachlorobenzene (HCB), which so far have not been developed or assessed. For the inventory development, the amended Toolkit methodology as developed for reporting under the Stockholm Convention on Persistent Organic Pollutants, has been applied. Based on the activity rate (AR) obtained from various statistical yearbooks, reports, or scientific literature, and the emission factors (EFs) suited to each technology level, we estimated the preliminary release inventories of unintentionally produced dl-PCB and HCB from 36 source categories in China for the reference year 2015...
December 12, 2018: Chemosphere
Xingru Zhao, Tingting Cui, Rui Guo, Yan Liu, Xing Wang, Yue-Xia An, Xiaocui Qiao, Binghui Zheng
In the present study, we developed a novel method to simultaneously detect eight classes of persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs), polybrominated diphenyl ethers (PBDEs), polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs), polychlorinated naphthalenes (PCNs), organochlorine pesticides (OCPs), short-chain chlorinated paraffins (SCCPs) and Dechlorane Plus (DP), in sediment and fish tissue samples...
January 24, 2019: Analytica Chimica Acta
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