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Mariana A Ribeiro, Molly S Estill, Geysson J Fernandez, Leonardo N Moraes, Stephen A Krawetz, Wellerson R Scarano
Male fertility and spermatogenesis are directly linked to the Sertoli cell's ability to produce factors associated with germ cell development. Sertoli cells express receptors for FSH and testosterone, and are the major regulators of spermatogenesis. Recent studies report that regulatory RNA molecules, such as microRNAs (miRNAs), are able to modulate testicular function during spermatogenesis and that their altered expression may be involved in male infertility. miRNAs may play a role in the response to xenobiotics that have an adverse consequences to health...
August 7, 2018: Toxicology
Wenbiao Li, Zijian Li, Aaron Jennings
Residential surface soil contamination is often addressed by the use of regulatory guidance values (RGVs), which specify the maximum allowed concentration that can be present without prompting a regulatory action. In the U.S., there are at least 72 jurisdictions, including national, state, and regional, that have published guidance values for one or more of the one hundred most frequently regulated chemicals. A standard-value-based comparison tool in this study is developed to analyze values from 40 states and from the U...
August 4, 2018: Science of the Total Environment
Yike Huang, Junchi He, Huaping Liang, Ke Hu, Shaoqiu Jiang, Lu Yang, Suyin Mei, Xiao Zhu, Jing Yu, Aize Kijlstra, Peizeng Yang, Shengping Hou
Uveitis is characterized as a common cause of blindness worldwide. Aryl hydrocarbon receptor (AhR), a ligand-activated nuclear receptor, has been implicated to play a role in human uveitis, although the exact mechanisms remain poorly understood. The purpose of this study was to enhance our knowledge concerning the role of AhR during intraocular inflammation. We immunized wild-type and AhR-knockout C57BL/6J mice with IRBP651-670 to induce experimental autoimmune uveitis (EAU). Disease severity was evaluated with both clinical and histopathological grading...
2018: Frontiers in Immunology
Viktoriia Burkina, Sidika Sakalli, Vladimir Zlabek, Galia Zamaratskaia
Naturally- and anthropogenically-produced cresols could pose serious risks to fish health. In this study, three piscine CYP isoforms were investigated for their abilities to interact with p-cresol. Therefore, the activity of 7-ethoxyresorufin-O-deethylase (EROD), 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase (BFCOD), and p-nitrophenol hydroxylase (PNPH) were evaluated in the hepatic microsomes of juvenile rainbow trout. Results showed that EROD activity was inhibited in a competitive manner, BFCOD activity was inhibited in presence the highest tested p-cresol concentration and PNPH activity was not affected...
July 26, 2018: Environmental Toxicology and Pharmacology
Masayoshi Yamaguchi, Oliver Hankinson
The aryl hydrocarbon receptor (AHR) is transcriptionally active in the form of a heterodimer with the AHR nuclear translocator, which then binds to the xenobiotic responsive element. AHR was originally discovered via its ligand, the polychlorinated hydrocarbon, 2,3,7,8‑tetrachlorodibenzo‑p‑dioxin (TCDD). In this study, we investigated whether TCDD regulates the growth of human liver cancer HepG2 cells in vitro. TCDD (0.1‑100 nM) was found to exert suppressive effects on the colony formation and proliferation of HepG2 cells, and stimulatory effects on the death of HepG2 cells when the cells reached subconfluence...
July 27, 2018: International Journal of Oncology
Zhong-Min Li, David Hernandez-Moreno, Katharina Maria Main, Niels Erik Skakkebæk, Hannu Kiviranta, Jorma Toppari, Ulla Feldt-Rasmussen, Heqing Shen, Karl-Werner Schramm, Meri De Angelis
In utero exposure to persistent organic pollutants (POPs) can result in thyroid function disorder, leading to concerns about their impact on fetal and neonatal development. The present study was performed to investigate the associations between placental levels of various POPs and thyroid hormones (THs). In a prospective Danish study initially established for assessing congenital cryptorchidism, 58 placenta samples were collected from mothers of boys born with (28) and without (30) cryptorchidism. The concentrations of polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs), organotin chemicals (OTCs), organochlorine pesticides (OCPs), thyroxine (T4), 3,3',5-triiodothyronine (T3), and 3,3',5'-triiodothyronine (rT3) were measured...
July 27, 2018: Endocrinology
Xiao-Xiao Hou, Guangjie Chen, Amir M Hossini, Tingting Hu, Lanqi Wang, Zhanyan Pan, Lingyi Lu, Ke Cao, Ying Ma, Christos C Zouboulis, Longqing Xia, Qiang Ju
Activation of Toll-like receptor (TLR)-2 and subsequent inflammatory response contribute to lesion development in acne vulgaris. A cross-talk between aryl hydrocarbon receptor (AhR), a cytosolic receptor protein that responds to environmental and physiological stress, and TLRs has recently been reported. In this study, we explored the possible role of AhR in the effects induced on cultured human SZ95 sebocytes by peptidoglycan (PGN), a classic TLR2 agonist. PGN-induced secretion of inflammatory factors TNF-α and IL-8 in human SZ95 sebocytes was suppressed after knockdown of AhR and pretreatment with the AhR antagonist CH223191...
July 27, 2018: Journal of Innate Immunity
Xueli Wang, Jiping Chen, Yuwen Ni
There is great concern about decreasing the amounts of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) that are formed and emitted during the chlorine bleaching of pulp. The formation of PCDD/Fs during non-woodpulp chlorine bleaching was investigated in the study described here. Wheat straw was separated into three components, cellulose, hemicellulose, and lignin. Chlorination experiments were performed, and lignin and hemicellulose contributed more than cellulose to PCDD/F formation when the pulp was bleached using chlorine...
July 24, 2018: Chemosphere
Anna Maria Sanangelantoni, Marina Malatrasi, Elisa Trivelloni, Giovanna Visioli, Caterina Agrimonti
β-propeller phytase-like sequences (BPP-like sequences) are widespread in the microbial world and have been found in the sequenced genomes of aquatic, soil, and plant bacteria. Exploring NCBI microbial genome database for putative genes encoding phytase, a BPP-like sequence from Sphingomonas wittichii RW-1 (Sequence ID: CP000699.1), known for its capacity of degrading polychlorinated dibenzo-p-dioxins and dibenzofurans, was recognized. The putative phytase gene (phySw) was amplified with specific primers, cloned, and overexpressed in Escherichia coli and the catalytic properties of the recombinant PhySw protein were analyzed...
July 27, 2018: Applied Microbiology and Biotechnology
Eun Mi Choi, Kwang Sik Suh, Woon-Won Jung, So Young Park, Sang Ouk Chin, Sang Youl Rhee, Youngmi Kim Pak, Suk Chon
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has various toxicological effects in adipose tissue. Evidence is accumulating that glabridin, a flavonoid extracted from licorice, has beneficial effects on the regulation of glucose homeostasis. In this study, we investigated whether glabridin suppresses TCDD-induced loss of adipogenic action using 3T3-L1 adipocytes as a cell culture model of wasting syndrome. Glabridin effectively suppressed TCDD-induced loss of lipid accumulation in this model. Pretreating cells with glabridin increased the gene expression of not only the adipogenesis-associated key transcription factors peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer binding protein alpha, but also lipoprotein lipase in the presence of TCDD...
July 26, 2018: Journal of Applied Toxicology: JAT
Haiping Xiao, Yu Ru, Zheng Peng, Dahai Yan, Li Li, Kåre Helge Karstensen, Ning Wang, Qifei Huang
During a three-day industrial trial, municipal solid waste incineration fly ash (FA) was co-processed in a cement kiln after water-washing pretreatment for waste-to-resource conversion. All inputs and outputs were sampled to obtain the dioxin fingerprints. During washing, the relative contents of polychlorinated dibenzo-p-dioxins and dibenzofurans in FA, washed FA and sludge were basically the same and only a simple physical migration resulted. During drying, only physical processes resulted, which included volatilization and migration...
July 19, 2018: Chemosphere
Jong Seong Khim, Jinsoon Park, Sung Joon Song, Seo Joon Yoon, Junsung Noh, Seongjin Hong, Bong-Oh Kwon, Jongseong Ryu, Xiaowei Zhang, Tieyu Wang, Yonglong Lu, John P Giesy
To investigate benthic ecological quality associated with coastal pollution in the Bohai Sea and northern Yellow Sea, a sediment quality triad (SQT) approach was applied. Chemical (six groups of persistent toxic substances (PTSs) and 8 metals and metalloids), toxicological (AhR-mediated potency), and ecological (bacterial and meiofaunal communities) elements were selected and used in an integrated sediment assessment. The benthic meiofaunal community was newly analyzed and used as an additional component of the infaunal community during the SQT...
July 18, 2018: Science of the Total Environment
Clémence Defois, Jérémy Ratel, Ghislain Garrait, Sylvain Denis, Olivier Le Goff, Jérémie Talvas, Pascale Mosoni, Erwan Engel, Pierre Peyret
Growing evidence indicates that the human gut microbiota interacts with xenobiotics, including persistent organic pollutants and foodborne chemicals. The toxicological relevance of the gut microbiota-pollutant interplay is of great concern since chemicals may disrupt gut microbiota functions, with a potential impairment of host homeostasis. Herein we report within batch fermentation systems the impact of food contaminants (polycyclic aromatic hydrocarbons, polychlorobiphenyls, brominated flame retardants, dioxins, pesticides and heterocyclic amines) on the human gut microbiota by metatranscriptome and volatolome i...
July 20, 2018: Scientific Reports
Liang Ding, Bingjie Cai, Shui Wang, Changsheng Qu
The concentrations, profiles, and spatial distributions of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in soil and sediment samples from several typical plastic solid waste (PSW) recovery sites (particularly from areas in which PSW is burned openly) in China were investigated. The results showed that burning PSW directly influenced PCDD/F concentrations immediately around the burning area. All of the samples in which soil contained black burning residue, collected from immediately around burning areas, had PCDD/F concentrations (mean 21708 ng kg-1 ) and toxic equivalent (TEQ) concentrations (mean 2140 ng I-TEQ kg-1 or 1877 ng WHO2006 -TEQ kg-1 ) more than 100 times higher than the concentrations in samples collected away from burning areas (mean 222 ng kg-1 , 8...
July 12, 2018: Environmental Pollution
Ying Ying Chen, King Ming Chan
Trace metal ions such as cadmium (Cd2+ ) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males...
July 12, 2018: Chemosphere
Xuefeng He, Yongsu Li, Meng Wang, Hui-Xuan Chen, Bin Chen, Hao Liang, Yaqi Zhang, Jiyan Pang, Liqin Qiu
Salicylic acids and substituted ynones were employed as substrates to afford a class of valuable 4H-benzo[d][1,3]dioxin-4-ones with a 2-site quaternary carbon structure in up to 92% yield by secondary amine-catalyzed dual Michael cascade reactions under mild reaction conditions. The α,β-unsaturated ketone as the key intermediate in the cascade process was successfully separated and characterized. As a result, a new reaction route for ynone species is demonstrated, which is totally different from the existing allenamine activation model...
August 1, 2018: Organic & Biomolecular Chemistry
Aruã C da Silva, Ana Teresa S Semeano, André H B Dourado, Henning Ulrich, Susana I Cordoba de Torresi
Electroactive biomaterials that are easily processed as scaffolds with good biocompatibility for tissue regeneration are difficult to design. Herein, the synthesis and characterization of a variety of novel electroactive, biodegradable biomaterials based on poly(3,4-ethylenedioxythiphene) copolymerized with poly(d,l lactic acid) (PEDOT- co -PDLLA) are presented. These copolymers were obtained using (2,3-dihydrothieno[3,4- b ][1,4]dioxin-2-yl)methanol (EDOT-OH) as an initiator in a lactide ring-opening polymerization reaction, resulting in EDOT-PDLLA macromonomer...
May 31, 2018: ACS Omega
Mahmoud Alawi, Mohanad Masaad, Maysa Al-Hussaini
The concentrations of POPs (persistent organic pollutants) including 16 compounds of OCPs, 12 dioxin-like PCBs congeners, and 17 PCDDs/Fs congeners were determined in 46 human adipose tissue samples gathered from Jordanian citizens. Thirteen adipose tissue samples of healthy people were collected from Jordan University Hospital and 33 adipose tissue samples of cancer-affected patients were collected from King Hussein Cancer Center. All samples were extracted, cleaned-up, and analyzed using GC/MS. In the healthy person's samples, among the OCP compounds, the highest concentration was found for heptachlor-oxo-epoxide (5696...
July 18, 2018: Environmental Monitoring and Assessment
Rong Cao, Haijun Zhang, Lijuan Zhao, Yichi Zhang, Ningbo Geng, Man Teng, Lili Zou, Yuan Gao, Yuwen Ni, Qiang Fu, Jiping Chen
Haze is a serious pollution problem during the wintertime in North China. In this study, we investigated how the periodic cycle of winter haze events affect the environmental behaviors of two typical persistent organic pollutants, namely, polychlorinated dibenzo- p-dioxins and dibenzofurans (PCDD/Fs) and polybrominated diphenyl ethers (PBDEs), in the atmosphere of a typical megacity, Beijing. The average atmospheric concentrations of the total di- to octa-CDD/Fs (∑PCDD/Fs: 378.0 pg/m3 ) and the total mono- to nona-BDEs (∑9h PBDEs: 166...
August 7, 2018: Environmental Science & Technology
Manuela Martano, Paola Stiuso, Angelo Facchiano, Salvatore De Maria, Daniela Vanacore, Brunella Restucci, Corrado Rubini, Michele Caraglia, Giampietro Ravagnan, Lorenzo Lo Muzio
Oral squamous cell carcinoma (OSCC) is one of the most aggressive and deadliest tumors worldwide. The aryl hydrocarbon receptor (AHR) is a nuclear transcription factor known as a dioxin receptor and mediates the toxic effects of industrial contaminants. In addition, AHR has been implicated in multiple cellular processes and its expression has been shown to play a critical role in tumorigenesis, including human oral cancer cell lines. In the present study, we evaluated the expression of AHR/HSP-90 in 25 formalin‑fixed, paraffin-embedded human oral cancer specimens by IHC analysis...
September 2018: Oncology Reports
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