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Hyaluronic acid and fibrosis

Shereen M Shedid, Nadia Abdel-Magied, Helen N Saada
Oxidative stress, apoptosis, and fibrosis may play a major role in the development of radiation-induced liver damage. Betaine, a native compound widely present in beetroot, was reported to possess hepato-protective properties. The objective of this study was to investigate the influence of betaine on radiation-induced liver damage. Animals were exposed to 9 Gy applied in 3 doses of 3 Gy/wk. Betaine (400 mg/kg/d), was orally supplemented to rats after the first radiation dose, and daily during the irradiation period...
October 11, 2018: Environmental Toxicology
Bin Xu, Ning-Ming Zhou, Wei-Tian Cao, Xiao-Jing Li
AIM: To investigate the value of ultrasound elastography combined with serological indexes in diagnosing liver fibrosis and assessing its severity. METHODS: A total of 338 chronic hepatitis B (CHB) patients were divided into a disease group (patients with hepatic fibrosis) and control group (subjects without hepatic fibrosis). The disease group was further divided into S1-S4 according to the degree of fibrosis. Independent risk factors for hepatic fibrosis were analyzed using multivariate logistic regression...
October 7, 2018: World Journal of Gastroenterology: WJG
Stergios A Polyzos, Aristidis Slavakis, Georgios Koumerkeridis, Panagiotis Katsinelos, Jannis Kountouras
The main aim of this study was the comparative evaluation of nonalcoholic fatty liver disease (NAFLD) fibrosis score (NFS), fibrosis 4 index (FIB-4), AST-to-Platelet Ratio Index (APRI), and enhanced liver fibrosis (ELF) test in distinguishing none/early (F0/F1) from significant/advanced (F2/F3) fibrosis in NAFLD patients, thereby providing an external validation cohort. Thirty-one patients with biopsy-proven NAFLD and 10 matched controls without NAFLD were prospectively enrolled. Serum hyaluronic acid (HA), aminoterminal propeptide of type III procollagen (PIIINP), tissue inhibitor of metallo-proteinases (TIMP)-1, and biochemical tests were measured...
October 1, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Gan-Rong Huang, Si-Jun Wei, Yan-Qiang Huang, Wei Xing, Lu-Yao Wang, Ling-Ling Liang
AIM: To reveal the protective mechanism of the combined use of vitamin D and puerarin in the progression of hepatic fibrosis induced by carbon tetrachloride (CCl4 ). METHODS: Eight-week-old male Wistar rats were randomly divided into a normal control group (C group), a CCl4 group (CCl4 group), a vitamin D group (V group), a puerarin group (P group), and a combined group of vitamin D and puerarin (V + P group), each of which contained ten rats. In this way, we built a rat model of CCl4 -induced hepatic fibrosis with intervention by vitamin D, puerarin, or a combination of the two...
September 28, 2018: World Journal of Gastroenterology: WJG
Junji Ueda, Hiroshi Yoshida, Yasuhiro Mamada, Nobuhiko Taniai, Masato Yoshioka, Atsushi Hirakata, Youichi Kawano, Tetsuya Shimizu, Tomohiro Kanda, Hideyuki Takata, Eiji Uchida
BACKGROUND: Recently, some reports have revealed a relationship between post-hepatectomy prognosis in hepatocellular carcinoma (HCC) and hepatic fibrosis markers. We evaluated the relationship between these markers of hepatic fibrosis, clinicopathological findings, and prognosis. METHODS: Three hundred and sixty patients underwent hepatectomy for HCC in the Nippon Medical School Hospital between 1993 and 2013. We divided these patients into two groups: normal serum hyaluronic acid (HA) levels and abnormal levels...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Esra Demirel, Kadri Yildiz, Kenan Çadirci, Hayati Aygün, Eyüp Şenocak, Betül Gündoğdu
OBJECTIVE: In this experimental study, PRF (Platelet Rich Fibrin), HA (Hyaluronic Acid) gel and ADCON® Gel were compared in terms of preventing epidural fibrosis. METHODS: Twenty-eight Sprague-Dawley rats (mean weight, 400-450 g) were divided into 4 groups. L3-L4 laminectomy was performed in each group. Following laminectomy, Adcon® Gel, HA gel and PRF were applied onto the surgery site locally in Group 1, 2 and 3, respectively. Group 4 was maintained as control without any local application...
September 11, 2018: Acta Orthopaedica et Traumatologica Turcica
Takuma Nakatsuka, Yoko Soroida, Hayato Nakagawa, Takahiro Shindo, Masaya Sato, Katsura Soma, Ryo Nakagomi, Tamaki Kobayashi, Momoe Endo, Hiromi Hikita, Mamiko Sato, Hiroaki Gotoh, Tomomi Iwai, Mariko Yasui, Aya Shinozaki-Ushiku, Kazuhiro Shiraga, Hiroko Asakai, Yoichiro Hirata, Masashi Fukayama, Hitoshi Ikeda, Yutaka Yatomi, Ryosuke Tateishi, Ryo Inuzuka, Kazuhiko Koike
AIM: Liver fibrosis caused by congestive hepatopathy has emerged as an important complication after Fontan procedure. We evaluated the utility of the hepatic vein (HV) waveform using Doppler ultrasound for identification of liver fibrosis in Fontan patients. METHODS: We investigated the HV waveforms in 41 Fontan patients and assessed correlations with clinical parameters, liver fibrosis markers, and hemodynamic data. RESULTS: Based on our preliminary analysis of 64 adult patients with chronic liver disease who underwent liver biopsy, we classified HV waveforms into five types with reference to the degree of flattening (from type 1, normal triphasic waveform; to type 5, a monophasic waveform indicating cirrhosis), and confirmed a significant correlation between waveform pattern and fibrosis stage...
September 4, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Kenneth M Estrellas, Liam Chung, Lindsay A Cheu, Kaitlyn Sadtler, Shoumyo Majumdar, Jyothi Mula, Matthew T Wolf, Jennifer H Elisseeff, Kathryn R Wagner
Recent studies have reported that the immune system significantly mediates skeletal muscle repair and regeneration. Additionally, biological scaffolds have been shown to play a role in polarizing the immune microenvironment toward pro-myogenic outcomes. Moreover, myostatin inhibitors are known to promote muscle regeneration and ameliorate fibrosis in animal models of Duchenne muscular dystrophy (DMD), a human disease characterized by chronic muscle degeneration. Biological scaffolds and myostatin inhibition can potentially influence immune-mediated regeneration in the dystrophic environment, but have not been evaluated together...
October 5, 2018: Journal of Biological Chemistry
Xiaoli Lou, Yanqiang Hou, Hui Cao, Jingjing Zhao, Fengting Zhu
Decoy receptor 3 (DcR3) is a tumor necrosis factor receptor, which may inhibit apoptosis. The aim of the present study was to investigate the clinical significance of DcR3 upregulation in patients with chronic hepatitis B (CHB) and hepatic fibrosis. A total of 128 patients with a clinical diagnosis of CHB who underwent liver biopsy were included in the present study. The expression levels of DcR3, hyaluronic acid (HA), type III procollagen, type IV collagen (IV-C) and laminin protein were assessed. The diagnostic value of DcR3 in patients with CHB with hepatic fibrosis was determined using receiver operating characteristic (ROC) curve analysis...
July 2018: Oncology Letters
Wataru Sumida, Hiroo Uchida, Takahisa Tainaka, Chiyoe Shirota, Akinari Hinoki, Takazumi Kato, Kazuki Yokota, Kazuo Oshima, Ryo Shirotuki, Kosuke Chiba, Yujiro Tanaka
PURPOSE: Biliary atresia (BA) is characterized by progressive inflammation of the biliary system. This inflammation persists and causes liver fibrosis, although jaundice disappears after Kasai portoenterostomy (KP). We aimed to confirm whether the oral administration of eicosapentaenoic acid (EPA) suppresses liver fibrosis in postoperative patients with BA. METHODS: We reviewed patients who underwent laparoscopic KP (lapKP) between January 2014 and September 2017...
October 2018: Pediatric Surgery International
Tingting Zeng, Jianlin Yu, Liming Tan, Yang Wu, Yongjian Tian, Qiong Wu, Xingwang Duan, Le Yu
OBJECTIVE: Noninvasive and simple tests to forecast cirrhosis is in great need clinically. This study aimed to assess the clinical significance of several noninvasive indices in predicting cirrhosis in Chinese patients with autoimmune hepatitis (AIH). MATERIALS AND METHODS: Liver function test and blood cell analysis were conducted in 76 AIH patients and 75 paired healthy subjects to calculate aspartate aminotransferase to alanine aminotransferase ratio(AAR), aspartate aminotransferase to platelet ratio index (APRI), fibrosis index based on the four factors (FIB-4), gamma-glutamyl transferase to platelet ratio (GPR), red blood cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR)...
November 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Hwansu Kang, Eunhui Seo, Jong-Moon Park, Na-Young Han, Hookeun Lee, Hee-Sook Jun
Mesenchymal stem cells (MSCs) have been investigated to treat liver diseases, but the efficiency of MSCs to treat chronic liver diseases is conflicting. FGF21 can reduce inflammation and fibrosis. We established FGF21-secreting adipose derived stem cells (FGF21_ADSCs) to enhance the effects of ADSCs and transplanted them into thioacetamide (TAA)-induced liver fibrosis mice via the tail vein. Transplantation of FGF21_ADSCs significantly improved liver fibrosis by decreasing serum hyaluronic acid and reducing the expression of fibrosis-related factors such as α-smooth muscle actin (α-SMA), collagen and tissue inhibitor of metalloproteinase-1 (TIMP-1) compared with the Empty_ADSCs by inhibition of p-JNK, NF-κB and p-Smad2/3 signalling...
October 2018: Journal of Cellular and Molecular Medicine
H Li, T Yan, Z Zhu, Z W Bao, T M Xu, J Xie, S Q Zheng, M M Cui, L G Liu
Objective: To study the correlation between the level of serum Chitinase-3-like protein 1 (CHI3L1) and the significant liver fibrosis and liver cirrhosis in patients with chronic liver disease, and to evaluate its diagnostic value. Methods: 165 patients with chronic liver disease were selected, liver histopathological examination was performed to detect serum CHI3L1 concentration. Four indexes of hepatic fibrosis (type III procollagen, collagen IV, laminin, hyaluronic acid), aspartate aminotransferase/platelet ratio index (APRI) and FIB-4 (fibrosis- 4) scores were based on the pathological findings of liver biopsy and compared the advantages and disadvantages of serum CHI3L1 with other methods for the diagnosis of hepatic fibrosis and liver cirrhosis...
May 20, 2018: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
Selmin Karataylı Özgürsoy, Fatma Tunçkaşık, M Emin Tunçkaşık, Egemen Akıncıoğlu, Handan Doğan, Güçlü Kaan Beriat
Objective: Various materials are used by otolaryngologists for vocal cord injections in the management of vocal cord paralysis. An ideal injection material should be long-term effective, readily available, cheap, easy to prepare, have no donor morbidity, easy to use, biocompatible, resistant to resorption or migration, and easy to extract during revision. In this study, we aimed to see the histopathological effects of hyaluronic acid (HYA) and platelet-rich plasma (PRP) injections into the vocal cords of New Zealand rabbits...
March 2018: Turkish archives of otorhinolaryngology
Yoshito Itoh, Yuya Seko, Toshihide Shima, Tomoaki Nakajima, Kei Mizuno, Yusuke Kawamura, Norio Akuta, Kiyoaki Ito, Miwa Kawanaka, Akira Hiramatsu, Michiie Sakamoto, Kenichi Harada, Yoshihito Goto, Takeo Nakayama, Hiromitsu Kumada, Takeshi Okanoue
AIM: Hepatic fibrosis is the most important factor for estimating the prognosis of patients with non-alcoholic fatty liver disease (NAFLD). A novel non-invasive scoring system, the FM-fibro index, showed high accuracy in a pilot study. The purpose of this study was to validate the efficacy of the FM-fibro index in a multicenter cohort. METHODS: Among 18 institutions, we analyzed 400 Japanese patients with biopsy-proven NAFLD. We evaluated the accuracies of the FM-fibro index, CA-fibro index, and European Liver Fibrosis (ELF) panel by area under the receiver operator characteristics curves (AUROC)...
July 4, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
N Plevris, R Sinha, A W Hay, N McDonald, J N Plevris, P C Hayes
BACKGROUND: Hyaluronic acid is a recognised noninvasive marker of liver fibrosis. However, its prognostic ability has not been extensively studied. AIMS: To investigate the ability of an index serum hyaluronic acid measurement to independently predict transplant-free survival in patients with liver disease of varying aetiology and severity. METHODS: This was a retrospective single-centre cohort study. Serum hyaluronic acid was measured at the discretion of the attending clinicians, in patients attending the liver clinic, to assess disease severity...
July 4, 2018: Alimentary Pharmacology & Therapeutics
Zhi-Wang Wang, Xiao-Yan Fu, Xiao-Li Cheng, Xiao-Ying Bao, Xue-Feng Liu, Hai-Jing Duan
OBJECTIVES: To observe the preventive and therapeutic action of Yuyin Ruangan Granule (YRG, Traditional Chinese Medicine) in hepatic fibrosis rats model and its effect on transforming growth factor-β1 (TGF-β1) expression. METHODS: The Wistar rats were randomly divided into 6 group ( n =10), and the model of hepatic fibrosis rats was established by subcutaneous injected with carbon tetrachloride (CCL4), fed on high-fat diet and 20% ethanol for 6 weeks, to survey the effect and mechanism of YRG preventing hypatic fibrosis by detecting liver function (the activity of alanine aminotransferase(ALT), aspartate aminotransferase(AST), etc...
February 8, 2018: Chinese Journal of Applied Physiology
R Kong, N Wang, H Luo, J Lu
BACKGROUND: Hesperetin, a natural component of citrus fruits, is indicated to have beneficial anti-inflammatory effects on injury and various cancers as a transforming growth factor beta (TGF-β) inhibitor. However, little evidence associates hesperetin with liver fibrosis. OBJECTIVE: Work from our laboratory aims at finding the mechanism by which hesperetin attenuates liver fibrosis. METHODS: Bile duct ligation (BDL) was used to induce liver fibrosis in mice and the findings were determined using enzyme-linked immunosorbent assay, quantitative realtime polymerase chain reaction, western blotting and immunohistochemical staining...
2018: Current Molecular Medicine
M J Nielsen, D Thorburn, D J Leeming, J R Hov, S Nygård, B Moum, F Saffioti, O H Gilja, K M Boberg, G Mazza, H Røsjø, M Pinzani, T H Karlsen, M A Karsdal, M Vesterhus
BACKGROUND: Primary sclerosing cholangitis is a progressive liver disease with a remarkably variable course. Biomarkers of disease activity or prognostic models predicting outcome at an individual level are currently not established. AIM: To evaluate the prognostic utility of four biomarkers of basement membrane and interstitial extracellular matrix remodeling in patients with primary sclerosing cholangitis. METHODS: Serum samples were available from 138 large-duct primary sclerosing cholangitis patients (of which 102 [74%] with IBD) recruited 2008-2012 and 52 ulcerative colitis patients (controls)...
July 2018: Alimentary Pharmacology & Therapeutics
Rong Wang, Jing Wang, Fuxing Song, Shengnan Li, Yongfang Yuan
Tanshinol, a water-soluble component isolated from Salvia miltiorrhiza Bunge , has a variety of biological activities involving anti-fibrotic effect. However, the exact role and the underlying mechanisms remain largely unclear. This study mainly focused on the anti-hepatic fibrotic activities and mechanisms of tanshinol on carbon tetrachloride (CCl4 )-induced liver fibrosis in rats via anti-oxidative and anti-inflammation pathways. The rats were divided into 4 groups as follows: control, model, tanshinol 20 mg/kg, and tanshinol 40 mg/kg...
2018: Drug Design, Development and Therapy
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