L Ferri, V Menghi, L Licchetta, P Dimartino, R Minardi, C Davì, L Di Vito, E Cifaldi, C Zenesini, F Gozzo, V Pelliccia, V Mariani, Y C C de Spelorzi, S Gustincich, M Seri, L Tassi, T Pippucci, F Bisulli
OBJECTIVE: This study investigates the prevalence of pathogenic variants in the mechanistic target of rapamycin (mTOR) pathway in surgical specimens of malformations of cortical development (MCDs) and cases with negative histology. The study also aims to evaluate the predictive value of genotype-histotype findings on the surgical outcome. METHODS: The study included patients with drug-resistant focal epilepsy who underwent epilepsy surgery. Cases were selected based on histopathological diagnosis, focusing on MCDs and negative findings...
March 19, 2024: Epilepsy & Behavior: E&B