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Drug-resistant AND epilepsy

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https://www.readbyqxmd.com/read/30100551/surgery-in-patients-with-childhood-onset-epilepsy-analysis-of-complications-and-predictive-risk-factors-for-a-severely-complicated-course
#1
Piergiorgio d'Orio, Michele Rizzi, Valeria Mariani, Veronica Pelliccia, Giorgio Lo Russo, Francesco Cardinale, Michele Nichelatti, Lino Nobili, Massimo Cossu
OBJECT: To compare the occurrence of surgery-related complications in patients with childhood-onset focal epilepsy operated on in the paediatric or in the adult age. To investigate risk factors for surgery-related complications in the whole cohort, with special attention to age at surgery and severe morbidity. METHODS: A cohort of 1282 patients operated on for childhood-onset focal epilepsy was retrospectively analysed. Occurrence of surgery-related complications, including a severely complicated course (SCC: surgical complication requiring reoperation and/or permanent neurological deficit and/or death), was compared between patients operated on in the paediatric age (<16 year-old; 452 cases) and, respectively, in adulthood (≥16 year-old; 830 cases)...
August 12, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30099235/evaluation-of-long-term-antiepileptic-drug-use-in-patients-with-temporal-lobe-epilepsy-assessment-of-risk-factors-for-drug-resistance-and-polypharmacy
#2
Agnes Balint Bjørke, Cecilie Gjessing Nome, Ragnhild Sørum Falk, Leif Gjerstad, Erik Taubøll, Kjell Heuser
PURPOSE: To evaluate risk factors for drug resistance and polypharmacy in patients with temporal lobe epilepsy. METHODS: Patients with temporal lobe epilepsy, treated for more than 5 years, completed questionnaires on antiepileptic drug use and effect. Logistic regression models were used for analysis of risk factors. RESULTS: Of 135 patients included in the study, 65% were classified as drug resistant and 41% identified as using polypharmacy...
July 17, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/30098361/identification-of-chemically-diverse-gaba-a-agonists-as-potential-anti-epileptic-agents-using-structure-guided-virtual-screening-admet-quantum-mechanics-and-clinical-validation-through-off-target-analysis
#3
Pakhuri Mehta, Shubham Srivastava, Manish Sharma, Inderpal Singh, Ruchi Malik
Development of resistance against existing anti-epileptic drugs has alarmed the scientific innovators to find novel potential chemical starting points for the treatment of epilepsy and GABAA inhibition is a promising drug target strategy against epilepsy. The crystal structure of a subtype-selective β3-homopentameric ligand-gated ion channel of GABAA receptor has been used for the first time for screening the Asinex library for discovery of GABAA agonists as potential anti-epileptic agents. Co-crystallized ligand established the involvement of part of the β7-β8 loop (Glu155 and Tyr157) and β9-β10 loop (Phe200 and Tyr205) residues as the crucial amino acids in effective binding, an essential feature, being hydrogen bond or ionic interaction with Glu155 residue...
August 8, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30097339/comparative-effectiveness-of-add-on-therapy-with-newer-generation-antiepileptic-drugs-in-bulgarian-patients-with-refractory-epilepsy
#4
Ekaterina Viteva, Zahari Zahariev
OBJECTIVES: The objective of this study is to perform an open, prospective study on various aspects of comparative effectiveness of newer-generation antiepileptic drugs as add-on therapy in Bulgarian patients with drug-resistant epilepsy. METHODS: The study was performed with the participation of 1259 patients with epilepsy who attended the Clinic of Neurology at the University Hospital in Plovdiv, Bulgaria for regular visits and completed diaries about seizure frequency, severity, and adverse events...
August 7, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30094180/working-memory-deficit-in-drug-resistant-epilepsy-with-an-amygdala-lesion
#5
Keiko Usui, Kiyohito Terada, Naotaka Usui, Kazumi Matsuda, Akihiko Kondo, Takayasu Tottori, Jun Shinozaki, Takashi Nagamine, Yushi Inoue
This study compared temporal lobe epilepsy (TLE) patients with amygdala lesion (AL) without hippocampal sclerosis (HS) (TLE-AL) with patients with TLE and HS without AL (TLE-HS). Both subtypes of TLE arose from the right hemisphere. The TLE-AL group exhibited a lower Working Memory Index (WMI) on the Wechsler Adult Intelligence Scale, third edition (WAIS-III), indicating that the amygdala in the right hemisphere is involved in memory-related function. [18F]fluorodeoxyglucose positron emission topography (FDG-PET) showed glucose hypometabolism limited to the right uncus for the TLE-AL group...
2018: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/30094179/sign-and-magnitude-scaling-properties-of-heart-rate-fluctuations-following-vagus-nerve-stimulation-in-a-patient-with-drug-resistant-epilepsy
#6
Eduardo Gutiérrez-Maldonado, Claudia Ivette Ledesma-Ramírez, Adriana Cristina Pliego-Carrillo, José Javier Reyes-Lagos
Vagus nerve stimulation (VNS) therapy has been recently incorporated in Latin America as a treatment for drug-resistant epilepsy. In particular, it is known that linear analysis and fractal parameters of heart rate variability (HRV) are able to indirectly measure cardiac autonomic activity. This case report presents a 17-year-old female with drug-resistant epilepsy implanted with a VNS device. In order to explore cardiac autonomic changes due to VNS, linear and fractal HRV indices were calculated in the presence and absence of neurostimulation...
2018: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/30093711/the-landscape-of-epilepsy-related-gator1-variants
#7
Sara Baldassari, Fabienne Picard, Nienke E Verbeek, Marjan van Kempen, Eva H Brilstra, Gaetan Lesca, Valerio Conti, Renzo Guerrini, Francesca Bisulli, Laura Licchetta, Tommaso Pippucci, Paolo Tinuper, Edouard Hirsch, Anne de Saint Martin, Jamel Chelly, Gabrielle Rudolf, Mathilde Chipaux, Sarah Ferrand-Sorbets, Georg Dorfmüller, Sanjay Sisodiya, Simona Balestrini, Natasha Schoeler, Laura Hernandez-Hernandez, S Krithika, Renske Oegema, Eveline Hagebeuk, Boudewijn Gunning, Charles Deckers, Bianca Berghuis, Ilse Wegner, Erik Niks, Floor E Jansen, Kees Braun, Daniëlle de Jong, Guido Rubboli, Inga Talvik, Valentin Sander, Peter Uldall, Marie-Line Jacquemont, Caroline Nava, Eric Leguern, Sophie Julia, Antonio Gambardella, Giuseppe d'Orsi, Giovanni Crichiutti, Laurence Faivre, Veronique Darmency, Barbora Benova, Pavel Krsek, Arnaud Biraben, Anne-Sophie Lebre, Mélanie Jennesson, Shifteh Sattar, Cécile Marchal, Douglas R Nordli, Kristin Lindstrom, Pasquale Striano, Lysa Boissé Lomax, Courtney Kiss, Fabrice Bartolomei, Anne Fabienne Lepine, An-Sofie Schoonjans, Katrien Stouffs, Anna Jansen, Eleni Panagiotakaki, Brigitte Ricard-Mousnier, Julien Thevenon, Julitta de Bellescize, Hélène Catenoix, Thomas Dorn, Martin Zenker, Karen Müller-Schlüter, Christian Brandt, Ilona Krey, Tilman Polster, Markus Wolff, Meral Balci, Kevin Rostasy, Guillaume Achaz, Pia Zacher, Thomas Becher, Thomas Cloppenborg, Christopher J Yuskaitis, Sarah Weckhuysen, Annapurna Poduri, Johannes R Lemke, Rikke S Møller, Stéphanie Baulac, Stéphanie Baulac
PURPOSE: To define the phenotypic and mutational spectrum of epilepsies related to DEPDC5, NPRL2 and NPRL3 genes encoding the GATOR1 complex, a negative regulator of the mTORC1 pathway METHODS: We analyzed clinical and genetic data of 73 novel probands (familial and sporadic) with epilepsy-related variants in GATOR1-encoding genes and proposed new guidelines for clinical interpretation of GATOR1 variants. RESULTS: The GATOR1 seizure phenotype consisted mostly in focal seizures (e...
August 10, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/30092753/cannabidiol-for-treating-drug-resistant-epilepsy-in-children-the-new-south-wales-experience
#8
Kerrie-Anne Chen, Michelle Farrar, Michael Cardamone, Deepak Gill, Robert Smith, Christopher T Cowell, Linda Truong, John A Lawson
OBJECTIVE: To evaluate the tolerability and safety of cannabidiol for treating drug-resistant epilepsy in children, and to describe adverse events associated with such treatment. STUDY DESIGN: Prospective, open label cohort study. SETTING: Three tertiary NSW referral centres with paediatric neurology services. PARTICIPANTS: First 40 children enrolled in the NSW Compassionate Access Scheme for children with drug-resistant epilepsy and uncountable daily seizures...
August 13, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/30090699/long-term-use-of-methylphenidate-in-a-boy-with-hypothalamic-tumor-drug-resistant-epilepsy-and-adhd
#9
Dobrinko Socanski, Nebojsa Jovic, Harald Beneventi, Anita Herigstad
•We report the successful treatment of a boy with hypothalamic tumor, gelastic seizures, drug-resistant epilepsy and ADHD•The use of methylphenidate significantly reduced symptoms of ADHD while seizure frequency remained unchanged.
2018: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/30090156/epileptic-encephalopathy-and-autism-a-complex-interplay
#10
Ashish H Chepure, Mansi P Somaiya, Alka A Subramanyam, Ravindra K Kamath
Drug-resistant epileptic encephalopathy such as Dravet syndrome presents with autistic symptoms. Three cases with autism spectrum disorder with comorbid Dravet syndrome were assessed. All the cases presented with onset of seizures before a year and with autistic features. The patients responded to a combination of antiepileptic drugs (AEDs), resulting in reduced frequency of seizures and behavioral issues. Contrary to the belief that both epilepsy and use of AEDs have adverse impact on the cognition of children with an early onset of epilepsy, we found improvement in the symptoms of our patients who presented with autism and epilepsy...
April 2018: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/30086482/in-vitro-and-in-vivo-experimental-models-employed-in-the-discovery-and-development-of-antiepileptic-drugs-for-pharmacoresistant-epilepsy
#11
REVIEW
Gonçalo Campos, Ana Fortuna, Amílcar Falcão, Gilberto Alves
Epilepsy is one of the most common chronic, recurrent and progressive neurological diseases. In spite of the large number of antiepileptic drugs currently available for the suppression of seizures, about one-third of patients develop drug-resistant epilepsy, even when they are administered the most appropriate treatment available. Thus, nonclinical models can be valuable tools for the elucidation of the mechanisms underlying the development of pharmacoresistance and also for the development of new therapeutic agents that may be promising therapeutic approaches for this unmet medical need...
July 21, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/30082241/jeavons-syndrome-clinical-features-and-response-to-treatment
#12
Kelsey M Smith, Paul E Youssef, Elaine C Wirrell, Katherine C Nickels, Eric T Payne, Jeffrey W Britton, Cheolsu Shin, Gregory D Cascino, Marc C Patterson, Lily C Wong-Kisiel
BACKGROUND: Jeavons syndrome is an underreported epileptic syndrome characterized by eyelid myoclonia, eyelid closure-induced seizures or electroencephalography paroxysms, and photosensitivity. Drug-resistant epilepsy is common, but the prognostic factors and clinical course leading to drug resistance have not been well characterized. METHODS: We identified 30 patients who met the diagnostic criteria of Jeavons syndrome at a single institution between January 1, 2000 and December 15, 2016...
July 10, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/30079754/microstructure-informed-connectomics-enriching-large-scale-descriptions-of-healthy-and-diseased-brains
#13
Sara Lariviere, Reinder Vos de Wael, Casey Paquola, Seok-Jun Hong, Bratislav Misic, Neda Bernasconi, Andrea Bernasconi, Leonardo Bonilha, Boris Bernhardt
Rapid advances in neuroimaging and network science have produced powerful tools and measures to appreciate human brain organization at multiple spatial and temporal scales. It is now possible to obtain increasingly meaningful representations of whole-brain structural and functional brain networks and to formally assess macroscale principles of network topology. In addition to its utility in characterizing healthy brain organization, individual variability, and lifespan-related changes, there is high promise of network neuroscience for the conceptualization, and ultimately, management of brain disorders...
August 5, 2018: Brain Connectivity
https://www.readbyqxmd.com/read/30073146/drug-resistant-epilepsy-with-mesial-temporal-sclerosis-as-possible-late-neurological-complication-in-two-aml-survivors-after-stem-cell-transplantation
#14
Kwan-Ming Karen Yam, Wing-Kwan Alex Leung, Xian-Lun Zhu, Lai-Wah Eva Fung
•Mesial temporal sclerosis (MTS) is a potential late complication of hematological malignancies.•Seizures are usually drug resistant with MTS yet seizure freedom may be achieved by surgery.•Early evaluation for epilepsy surgery is warranted for drug resistant seizures due to AML.
2018: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/30073144/therapeutic-augmentation-of-ketogenic-diet-with-a-sodium-glucose-cotransporter-2-inhibitor-in-a-super-refractory-status-epilepticus-patient
#15
Joseph R Blunck, Joseph W Newman, Ronald K Fields, John E Croom
Background: A ketogenic diet (KD) may have a role in treating patients in super-refractory status epilepticus (SRSE). Sodium-glucose cotransporter 2 (SGLT2) inhibitors have a risk of ketoacidosis that could facilitate induction of KD. Case summary: A 42-year-old with a history of drug resistant epilepsy developed SRSE requiring several pharmacological interventions during her hospital course including the initiation of KD that failed. SGLT2 inhibitor therapy was initiated in a successful attempt to augment ketone production...
2018: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/30066373/-time-is-brain-how-early-should-surgery-be-done-in-drug-resistant-tle
#16
Ashalatha Radhakrishnan, Ramshekhar Menon, Sanjeev V Thomas, Mathew Abraham, George Vilanilam, Chandrashekharan Kesavadas, Bejoy Thomas, Ajith Cherian, Ravi Prasad Varma
OBJECTIVES: To explore the effect of duration of epilepsy and delay in surgery on seizure outcome in patients operated for drug-resistant temporal lobe epilepsy (TLE). MATERIALS & METHODS: 664 consecutive patients who underwent anterior temporal lobectomy (ATL) for TLE from 1995 to 2008 formed the study cohort. We divided them into two, one as seizure-free with or without antiepileptic drugs after ATL as "good outcome" (Engel Class I a) and seizures of any type, any time after surgery as "poor outcome"...
July 31, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/30066084/psychiatric-symptoms-in-refractory-epilepsy-during-the-first-year-after-surgery
#17
Sònia Ramos-Perdigués, Eva Baillés, Anna Mané, Mar Carreño, Antonio Donaire, Jordi Rumià, Nuria Bargalló, Teresa Boget, Xavier Setoain, Manuel Valdés, Luís Pintor
Psychiatric morbidity in drug-resistant epilepsy is frequent. Surgery is the best therapeutic alternative for treating seizures, but the current evidence concerning the effects of surgery on psychiatric disorders (PDs) is inconclusive. We aim to clarify surgery's role in long-term PDs. Using a prospective controlled study, we analyzed the psychopathologic outcomes of patients with drug-resistant epilepsy, comparing those who underwent surgery to those who did not due to not being suitable. Surgical candidates were paired (n = 84) with the immediately following nonsurgical candidates (n = 68)...
July 31, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/30064326/deep-brain-stimulation-for-seizure-control-in-drug-resistant-epilepsy
#18
Neil Klinger, Sandeep Mittal
Antiepileptic drugs prevent morbidity and death in a large number of patients suffering from epilepsy. However, it is estimated that approximately 30% of epileptic patients will not have adequate seizure control with medication alone. Resection of epileptogenic cortex may be indicated in medically refractory cases with a discrete seizure focus in noneloquent cortex. For patients in whom resection is not an option, deep brain stimulation (DBS) may be an effective means of seizure control. Deep brain stimulation targets for treating seizures primarily include the thalamic nuclei, hippocampus, subthalamic nucleus, and cerebellum...
August 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/30062085/seizure-frequency-can-be-reduced-by-changing-intracranial-pressure-a-case-report-in-drug-resistant-epilepsy
#19
Daiki Uchida, Ayataka Fujimoto, Tomohiro Yamazoe, Takamichi Yamamoto, Hideo Enoki
A relationship between seizures and intracranial pressure (ICP) has been proposed, but not clearly identified. Whether changes in ICP can evoke seizures remains controversial. We report the case of a 23-year-old man who had undergone shunt surgery in childhood and later presented with focal impaired awareness seizures and behavior arrest. Seizures were uncontrolled despite 3 years of pharmacotherapy, but suddenly stopped after shunt removal. Our case supports the hypothesis that drug-resistant epilepsy can be influenced by changes in ICP...
2018: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/30062084/drug-resistant-epilepsy-development-following-stem-cell-transplant-and-cyclosporine-neurotoxicity-induced-seizures-case-report-in-an-adult-and-analysis-of-reported-cases-in-the-literature
#20
Adam S Vesole, Yasunori Nagahama, Mark A Granner, Matthew A Howard, Hiroto Kawasaki, Brian J Dlouhy
Introduction: Drug-resistant epilepsy (DRE) occurs in 20-30% of all patients who develop epilepsy and can occur from diverse causes. Cyclosporine-A (CSA) is an immunosuppressive drug utilized to prevent graft-versus-host disease (GvHD) in transplant patients and is known to cause neurotoxicity, including seizures. In some cases, however, patients can develop DRE. Only a limited number of cases have been reported in which DRE has developed after CSA exposure - all in children. Here we present a rare case of an adult developing DRE after post-transplant CSA neurotoxicity...
2018: Epilepsy & Behavior Case Reports
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