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biomaterials in surgery

Maximilian E T Hessenauer, Kirsten Lauber, Gabriele Zuchtriegel, Bernd Uhl, Timon Hussain, Martin Canis, Sebastian Strieth, Alexander Berghaus, Christoph A Reichel
Rapid implant vascularization is a prerequisite for successful biomaterial engraftment. Vitronectin (VN) is a matricellular glycoprotein well known for its capability to interact with growth factors, proteases, and protease inhibitors/receptors. Since such proteins are highly relevant for angiogenic processes, we hypothesized that VN contributes to the tissue integration of biomaterials. Employing different in vivo and ex vivo microscopy techniques, engraftment of porous polyethylene (PPE) implants was analyzed in the dorsal skinfold chamber model in wild-type (WT) and VN-/- mice...
October 5, 2018: Acta Biomaterialia
Mohamed F Attia, Beau R Brummel, Timothy R Lex, Brooke A Van Horn, Daniel C Whitehead, Frank Alexis
Several synthetic materials exhibiting contrast imaging properties have become vital to the field of biomedical imaging. Polymeric biomaterials and metals are commonly used imaging agents and can assist in the monitoring of therapy response, migration, degradation, changes in morphology, defects, and image-guided surgery. In comparison to metals, most bio and synthetic polymers lack inherent imaging properties. Polymeric biomaterials, specifically polyesters, have gained a considerable amount of attention due to their unique properties including biocompatibility, biodegradation, facile synthesis, and modification capability...
October 8, 2018: Advanced Healthcare Materials
Ignasi Casanellas, Andrea García-Lizarribar, Anna Lagunas, Josep Samitier
The human musculoskeletal system is comprised mainly of connective tissues such as cartilage, tendon, ligaments, skeletal muscle, and skeletal bone. These tissues support the structure of the body, hold and protect the organs, and are responsible of movement. Since it is subjected to continuous strain, the musculoskeletal system is prone to injury by excessive loading forces or aging, whereas currently available treatments are usually invasive and not always effective. Most of the musculoskeletal injuries require surgical intervention facing a limited post-surgery tissue regeneration, especially for widespread lesions...
2018: Frontiers in Bioengineering and Biotechnology
Michael Anis Mihdi Afnan, Amulya Kumar Saxena
BACKGROUND: There has been increased interest in the use of biomaterials that resorb completely leaving only the patient's native tissue. Synthetic materials are advantageous for tissue repair because they are highly customisable. The infection rate of using resorbable natural materials in paediatric surgery has recently been outlined, but there has not yet been a review of the use of synthetic resorbable materials in paediatric surgery. OBJECTIVES: This systematic review analyses the risk of infection after implantation of fully resorbable synthetic biomaterials in paediatric cases...
September 26, 2018: Bio-medical Materials and Engineering
J Zhao, J-J Xu
OBJECTIVE: An inguinal hernia is the most common type of external abdominal hernia. Normal surgery utilized polypropylene mesh to fix a hernia, but often leads to adverse effects including pain and foreign body sensation. Adipose-derived stem cells are pluripotent stem cells that can be differentiated into adipocytes, chondrocytes, skeletal myoblast and osteoblast. The compatibility of stem cells with absorbent material mesh or cellular biology mesh has been studied. This study investigated the application of adipose-derived stem cells coated polypropylene mesh in treating an inguinal hernia...
September 2018: European Review for Medical and Pharmacological Sciences
Nazzar Tellisi, Nureddin A Ashammakhi, Fabrizio Billi, Outi Kaarela
Implants are being continuously developed to achieve personalized therapy. With the advent of 3-dimensional (3D) printing, it is becoming possible to produce customized precisely fitting implants that can be derived from 3D images fed into 3D printers. In addition, it is possible to combine various materials, such as ceramics, to render these constructs osteoconductive or growth factors to make them osteoinductive. Constructs can be seeded with cells to engineer bone tissue. Alternatively, it is possible to load cells into the biomaterial to form so called bioink and print them together to from 3D bioprinted constructs that are characterized by having more homogenous cell distribution in their matrix...
October 1, 2018: Journal of Craniofacial Surgery
Leandro Chambrone, Maria Aparecida Salinas Ortega, Flávia Sukekava, Roberto Rotundo, Zamira Kalemaj, Jacopo Buti, Giovan Paolo Pini Prato
BACKGROUND: Gingival recession is defined as the oral exposure of the root surface due to a displacement of the gingival margin apical to the cemento-enamel junction and it is regularly linked to the deterioration of dental aesthetics. Successful treatment of recession-type defects is based on the use of predictable root coverage periodontal plastic surgery (RCPPS) procedures. This review is an update of the original version that was published in 2009. OBJECTIVES: To evaluate the efficacy of different root coverage procedures in the treatment of single and multiple recession-type defects...
October 2, 2018: Cochrane Database of Systematic Reviews
Iris Bischoff, Roman Tsaryk, Feng Chai, Robert Fürst, Charles James Kirkpatrick, Ronald E Unger
Patients diagnosed with osteosarcoma are currently treated with intravenous injections of anticancer agents after tumor resection. However, due to remaining neoplastic cells at the site of tumor removal, cancer recurrence often occurs. Successful bone regeneration combined with the control of residual cancer cells presents a challenge for tissue engineering. Cyclodextrins loaded with chemotherapeutic drugs reversibly release the drugs over time. Hydroxyapatite bone biomaterials coated with doxorubicin-loaded cyclodextrin should release the drug with time after implantation directly at the original tumor site and may be a way to eliminate residual neoplastic cells...
December 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Francesco Pisanu, Carlo Doria, Matteo Andreozzi, Marco Bartoli, Laura Saderi, Giovanni Sotgiu, Paolo Tranquilli Leali
PURPOSE: To summarize the biological effects of metal debris from hip arthroplasties which characterize a polymorphic clinical spectrum of local and remote manifestation. METHODS: Retrospective study. Patient, implant, and surgical characteristics were collected, including implant survival, clinical manifestations, cause of arthroplasty revision or implant failure, and peri- and intra-operative complications. The primary endpoint was implant survivorship. Hip revision arthroplasty was decided considering clinical signs and symptoms, abnormal imaging (XR, MR, TC, echotomography, scintigraphy), and blood metal ion level...
September 29, 2018: International Orthopaedics
Ratna Varma, Fabio G Aoki, Kayla Soon, Golnaz Karoubi, Thomas K Waddell
Tracheal injury, stenosis, and malignancy demand tracheal reconstruction, which often fails due to the lack of a functioning epithelium. We performed an extensive comparative analysis to determine optimal biomaterials for developing tracheal epithelial grafts with mucociliary function. We screened Hyaluronan-Poly(Ethylene Glycol), Chitosan-Collagen, Collagen Vitrigel Membrane, Fibrin Glue, Silk Fibroin, and Gelatin based on various parameters including mechanical strength, bulk degradation, cell attachment, spreading, metabolic activity, focal adhesion formation, and differentiation into ciliated and goblet cells...
September 27, 2018: Acta Biomaterialia
M A S Munhoz, H H Hirata, A M G Plepis, V C A Martins, M R Cunha
In traumatology, we encounter several clinical challenges that involve extensive bone loss primarily related to trauma, conditions that can be treated with autologous grafts. A good alternative is the use of synthetic biomaterials as substitutes. These polymers provide a suitable environment for the growth of new bone and vascular tissue, which are essential for repair. Collagen/hydroxyapatite composites have proven to be biocompatible and to behave mechanically. Furthermore, the addition of chitosan contributes to the formation of a three-dimensional structure that permits cell adhesion and proliferation, thus improving osteogenesis...
September 20, 2018: Injury
Bo Wang, Peng Li, Lei Shangguan, Jun Ma, Kezheng Mao, Quan Zhang, Yiguo Wang, Zhongyang Liu, Keya Mao
Introduction: Failed back surgery syndrome is a situation where there is failure after lumbar surgery aimed at correcting lumbar disease that is characterized by continuous back and/or leg pain. Epidural fibrosis and adhesions are among the major causes of failed back surgery syndrome. In recent years, several biomaterials have been applied as barriers or deterrents to prevent the compression of neural structures by postsurgical fibrosis. Methods: In this study, a new bacterial cellulose (BC) anti-adhesion membrane, composed of exosomes from human umbilical cord mesenchymal stem cells, was developed...
2018: International Journal of Nanomedicine
Peng Li, HuiCong Zhu, DaHong Huang
PURPOSE: Demineralized dentin matrix (DDM) from the patient's own extracted healthy tooth can be recycled as an autogenous biomaterial for reconstructive dentistry. The aim of the present study was to evaluate the clinical efficacy of autogenous DDM versus Bio-Oss granules in guided bone regeneration (GBR) for immediate implantation in periodontal postextraction sites. MATERIALS AND METHODS: From November 2015 to March 2017, patients referred to the Foshan Stomatology Hospital, who had been diagnosed with severe periodontitis of the posterior mandibular tooth and agreed to dental implant treatment, were consecutively included...
September 19, 2018: Clinical Implant Dentistry and related Research
Xiaolei Nie, Dong-An Wang
In orthopaedic surgery, the reconstruction of musculoskeletal defects is a constant challenge. Biomaterials in tissue engineering are utilized as scaffolds which serve as templates for cell proliferation and secretion as well as guides for new tissue formation. The extracellular matrix (ECM) is a desirable biological scaffold due to its complex composition and three-dimensional ultrastructure, which drive the homeostasis and regeneration of tissues. Successfully used in a variety of regenerative medicine applications, ECM scaffolds can be achieved by decellularization of engineered tissue...
September 19, 2018: Biomaterials Science
Marek Konop, Joanna Czuwara, Ewa Kłodzińska, Anna K Laskowska, Urszula Zielenkiewicz, Iwona Brzozowska, Seyed M Nabavi, Lidia Rudnicka
Impaired wound healing is a major medical problem in diabetes. The objective of this study was to determine the possible application of an insoluble fraction of fur-derived keratin biomaterial as a wound dressing in a full thickness surgical skin wound model in mice ( n = 20) with iatrogenically induced diabetes. The obtained keratin dressing was examined in vitro and in vivo. In vitro study showed the keratin dressing is tissue biocompatible and non-toxic for murine fibroblasts. Antimicrobial examination revealed the keratin dressing inhibited the growth of S...
September 18, 2018: Journal of Biomaterials Applications
Nael Berri, Jawad Fares, Youssef Fares
Background: Tissue engineering and biomaterials have made it possible to innovate bone treatments for orthopedic and spine problems. The aim of this study is to develop a novel polyethylene oxide (PEO)/silicon-substituted hydroxyapatite (Si-HA) composite to be used as a scaffold for hard tissue engineering in orthopedic and spine procedures. Materials and Methods: The composite was fabricated through the electrospinning technique. The applied voltage (5 kV) and PEO concentration (5%) were fixed...
2018: Advanced Biomedical Research
Mohammed Yunus, Mohammad S Alsoufi
Hybrid polymer matrix composites (HPMC) are prominent material for the formation of biomaterial and offer various advantages such as low cost, high strength, and the fact that they are easy to manufacture. However, they are associated with low mechanical (low hardness) and tribological properties (high wear rate). The average hip joint load fluctuates between three to five times of the body weight during jumping and jogging and depends on various actions relating to body positions. Alternate bone and prosthesis material plays a critical role in attaining strength as it determines the method of load transferred to the system...
2018: International Journal of Biomaterials
Umran Aydemir Sezer, Zeynep Kocer, İsa Sahin, Basak Aru, Gulderen Yanıkkaya Demirel, Serdar Sezer
Effective hemostatic materials are of utmost importance for preventing bleeding in emergencies and critical injuries. Combining biodegradability, good hemostatic properties and biocompatibility, gelatin is one of the most reliable materials clinically used for preventing internal bleeding in surgeries and for stopping external hemorrhage. Cross-linking is a useful method for enhancing the absorption capacity of gelatin and for controlling the degradation process. Existing and commonly used aldehyde-containing cross-linking agents lack reliability with respect to the control of hemostatic effect, solubility and toxicity...
November 15, 2018: Carbohydrate Polymers
Zbigniew Draczyński, Tomasz Gąsiorowski, Beata Kolesińska, Maciej Boguń, Witold Sujka
BACKGROUND: Biocompatible materials are used for treatment of blood circulatory system diseases, especially abdominal aortic aneurysms. The most popular and often used are knitted and polymer vascular patches. The aim of this study was to optimize the manufacturing process of implantable materials, ensuring antibacterial activity useful for treating abdominal aorta aneurysms. METHODS: The vascular patch was manufactured from Trevira® yarn. The parameters of the intermediate product and vascular patch were tested according to standard procedures...
September 3, 2018: Journal of Applied Biomaterials & Functional Materials
Ranjeet A Bapat, Chaitanya P Joshi, Prachi Bapat, Tanay V Chaubal, Rohit Pandurangappa, Naveen Jnanendrappa, Bapi Gorain, Sukant Khurana, Prashant Kesharwani
Maintenance of oral health is a major challenge in dentistry. Different materials have been used to treat various dental diseases, although treatment success is limited by features of the biomaterials used. To overcome these limitations, materials incorporated with nanoparticles (NPs) can be used in dental applications including endodontics, periodontics, tissue engineering, oral surgery, and imaging. The unique properties of NPs, including their surface:volume ratio, antibacterial action, physical, mechanical, and biological characteristics, and unique particle size have rendered them effective vehicles for dental applications...
August 31, 2018: Drug Discovery Today
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