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biomaterials in surgery

Carina Kampleitner, Jessika Obi, Nicola Vassilev, Michelle M Epstein, Oskar Hoffmann
Large non-union bone fractures are a significant challenge in orthopedic surgery. Although auto- and allogeneic bone grafts are excellent for healing such lesions, there are potential complications with their use. Thus, material scientists are developing synthetic, biocompatible biomaterials to overcome these problems. In this study, we present a multidisciplinary platform for evaluating biomaterials for bone repair. We combined expertise from bone biology and immunology to develop a platform including in vitro osteoclast (OC) and osteoblast (OB) assays and in vivo mouse models of bone repair, immunogenicity, and allergenicity...
November 16, 2018: Journal of Visualized Experiments: JoVE
Razvan Vladimir Nanu, Emil Ungureanu, Sinziana Luminita Instrate, Alexandra Vrapciu, Roxana Cozubas, Laura Carstocea, Liliana Mary Voinea, Radu Ciuluvica
Posterior capsule opacification remains till nowadays one of the most hypothetical problems concerning the cataract surgery. When it comes in preventing PCO, this complication is made in multiple ways that concern, along with the surgery steps, the choice for the biomaterial of the intraocular implant lens. The concern of influence of the type of the used material (hydro-phob/ hydro-philic), of the design of the implant (1-piece IOL = monobloc vs. 3 - piece IOL - multipiece) and with the design at the edge, they all have been considered in multiple studies...
July 2018: Romanian Journal of Ophthalmology
Young Jin Park, Jong Hyun Cha, Sa Ik Bang, So Young Kim
BACKGROUND: This clinical study aimed to investigate the safety and surgical outcome of three-dimensionally (3D) fabricated polycaprolactone (PCL) mesh in rhinoplasty. In particular, this study explored how a 3D-printed PCL mesh performs as a bioabsorbable scaffold after a long period following implantation. METHODS: A retrospective review of 101 patients who received primary or secondary rhinoplasty with a PCL mesh was performed. Patient demographics and surgery-related outcomes were examined...
November 29, 2018: Aesthetic Plastic Surgery
Silvia Scevola, Marco Mario Tresoldi, Angela Faga
OBJECTIVES: Regenerative Surgery aims at the restoration of the loss of structures and functions of the body using four innovative approaches: physical energies, biomaterials, cell products and stem cells. METHODS: The Authors provide an overview of their experience with Regenerative Surgery procedures at the Plastic Surgery Unit of the University of Pavia, Istituti Clinici Scientifici Salvatore Maugeri, in a 10 years period, from 2007 to 2017, for the treatment of extensive acute soft tissue loss, chronic ulcers, disabling scars and degenerative pathologies with different aethiology...
June 2018: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
Felasfa M Wodajo, Adam E Jakus
In part 1 of this article, the authors explore nanoscale modifications of the surfaces of biomaterials, which offer an exciting potential venue for the prevention of bacterial adhesion and growth. Despite advances in the design and manufacture of implants, infection remains an important and often devastating mode of failure. In part 2, additive technologies for tissue engineering, live cell printing (bioprinting), and tissue fabrication are briefly introduced. The similarities and differences between bioprinting and non-bio 3D-printing approaches and requirements are discussed, along with terminological definitions, current processes, requirements, and biomaterial and cell-type selection and sourcing...
January 2019: Orthopedic Clinics of North America
Raffaele Pugliese, Mahboubeh Maleki, Ronald N Zuckermann, Fabrizio Gelain
Self-assembling peptides (SAPs) are synthetic bioinspired biomaterials that can be feasibly multi-functionalized for applications in surgery, drug delivery, optics and tissue engineering (TE). Despite their promising biocompatibility and biomimetic properties, they have never been considered real competitors of polymers and/or cross-linked extracellular matrix (ECM) natural proteins. Indeed, synthetic SAP-made hydrogels usually feature modest mechanical properties, limiting their potential applications, due to the transient non-covalent interactions involved in the self-assembling phenomenon...
November 26, 2018: Biomaterials Science
Eun-Jae Chung
The current treatments for esophageal diseases, such as carcinomas, trauma or congenital malformations, require surgical intervention and esophageal reconstruction using redundant parts of the gastrointestinal tract. However, the use of gastrointestinal segments can cause various surgical morbidities and mortality because additional abdominal surgery may be required at the expense of other anatomic structures. Therefore, tissue engineering using various biomaterial or cell sources has emerged as an alternative strategy of biomimicking the native esophageal tissue that could be implanted as an artificial graft...
2018: Advances in Experimental Medicine and Biology
Qian Liu, Yinxian Yu, Ramona L Reisdorf, Jun Qi, Chun-Kuan Lu, Lawrence J Berglund, Peter C Amadio, Steven L Moran, Scott P Steinmann, Kai-Nan An, Anne Gingery, Chunfeng Zhao
Reducing rotator cuff failure after repair remains a challenge due to suboptimal tendon-to-bone healing. In this study we report a novel biomaterial with engineered tendon-fibrocartilage-bone composite (TFBC) and bone marrow-derived mesenchymal stem cell sheet (BMSCS); this construct was tested for augmentation of rotator cuff repair using a canine non-weight-bearing (NWB) model. A total of 42 mixed-breed dogs were randomly allocated to 3 groups (n = 14 each). Unilateral infraspinatus tendon underwent suture repair only (control); augmentation with engineered TFBC alone (TFBC), or augmentation with engineered TFBC and BMSCS (TFBC + BMSCS)...
October 29, 2018: Biomaterials
Vladimir Kovač
PURPOSE: To analyze and clarify conflicting aspects of fusion and total disc replacement (TDR) surgery in literature. METHOD: Using keywords, 23 literature reviews, 41 studies accepted by "importance criteria" from the Internet, and 16 articles "published in 2018" were chosen. Altogether 80 studies. RESULTS: General assessment was mentioned as affirmative for TDR in 40 papers, five were negative, 24 without clear decision...
November 13, 2018: International Orthopaedics
(no author information available yet)
No abstract text is available yet for this article.
December 2018: Annals of Surgery
Lauren Tennyson, Matthew Rytel, Stacy Palcsey, Leslie Meyn, Rui Liang, Pamela Moalli
BACKGROUND: Polypropylene mesh is widely used for surgical treatment of pelvic organ prolapse and stress urinary incontinence. While these surgeries demonstrate favorable functional and anatomical outcomes, their use has been limited by complications, the two most common being exposure and pain. Growing evidence suggests T lymphocytes play a critical role in regulating the host response to biomaterials. OBJECTIVES: To define and characterize the T cell response and correlate the response to collagen deposition in fibrotic capsules in mesh tissue complexes removed for the complications of pain versus exposure...
November 9, 2018: American Journal of Obstetrics and Gynecology
Gianluca Turco, Davide Porrelli, Eleonora Marsich, Federica Vecchies, Teresa Lombardi, Claudio Stacchi, Roberto Di Lenarda
BACKGROUND: Bone substitutes, either from human (autografts and allografts) or animal (xenografts) sources, suffer from inherent drawbacks including limited availability or potential infectivity to name a few. In the last decade, synthetic biomaterials have emerged as a valid alternative for biomedical applications in the field of orthopedic and maxillofacial surgery. In particular, phosphate-based bone substitution materials have exhibited a high biocompatibility due to their chemical similitude with natural hydroxyapatite...
November 8, 2018: Journal of Functional Biomaterials
Igor Guimarães Barros Paulinelli Santos, Carolina Miler Mattos de Santana, Adriana Therezinha Neves Novelino Alves, Marcelo José Pinheiro Gueded de Uzeda, Mônica Diuana Calasans-Maia, Ronaldo Barcellos de Santana
BACKGROUND: alveolar volumetric changes are inherent to the healing process after tooth extraction and filling of the extraction site with biomaterials can reduce these volumetric changes and provide a more favorable environment for the future prosthetic restoration with implants. Among the biomaterials available, biphasic ceramic compounds have shown promissing clinical results, however, histological evaluation of bone tissue response to different hydration and incorporation methods are limited...
October 27, 2018: Journal of Periodontology
John-Jairo Aguilera-Correa, Aranzazu Mediero, Francisco-Miguel Conesa-Buendía, Ana Conde, María-Ángeles Arenas, Juan-José de-Damborenea, Jaime Esteban
Joint prosthesis failure is mainly related to aseptic loosening and prosthetic joint infections, both of which are associated with high morbidity and substantial costs for patients and health systems. The development of a biomaterial that is capable of stimulating bone growth while minimizing bacterial adhesion would reduce the incidence of prosthetic failure. We report antibacterial and osteostimulatory effects in a novel F-P-doped TiO2 oxide film grown on Ti-6Al-4V alloy with a nanostructure of bottle-shape nanotubes -bNT samples-using five bacterial species ( Staphylococcus aureus , S...
October 26, 2018: Applied and Environmental Microbiology
Guanbao Li, Pinquan Li, Qiuan Chen, Hnin Ei Thu, Zahid Hussain
BACKGROUND: Owing to their great promise in the spinal surgeries, bone graft substitutes have been widely investigated for their safety and clinical potential. By the current advances in the spinal surgery, an understanding of the precise biological mechanism of each bone graft substitute is mandatory for upholding the induction of solid spinal fusion. OBJECTIVE: The aim of the present review is to critically discuss various surgical implications and level of evidence of most commonly employed bone graft substitutes for spinal fusion...
October 24, 2018: Current Drug Delivery
In Woong Um
A bone graft and bone graft substitute should have at least one of the following properties: it should be (1) osteogenic, (2) osteoinductive and/or (3) osteoconductive. In addition, bone graft substitutes should be biocompatible and bioresorbable as well as easy to use and cost effective. Autologous cancellous bone is the clinical gold standard in bone grafting procedures1, 4 and it has osteogenic, osteoinductive, and osteoconductive properties. Because of disadvantages associated with harvesting autologous bone graft material, such as requiring an additional operation and possible donor site morbidity, there is a need for an alternative in terms of enhancing the bone healing for the treatment of large bony defects...
2018: Advances in Experimental Medicine and Biology
Lynn L H Huang, Ying-Hui Amy Chen, Zheng-Ying Zhuo, Ya-Ting Hsieh, Chia-Ling Yang, Wei-Ting Chen, Jhih-Ying Lin, You-Xin Lin, Jian-Ting Jiang, Chao-Hsung Zhuang, Yi-Ching Wang, Hanhhieu Nguyendac, Kai-Wei Lin, Wen-Lung Liu
In order to develop and commercialize for the regenerative medicinal products, smart biomaterials with biocompatibility must be needed. In this chapter, we introduce collagen and hyaluronic acid (HA) as extracellular matrix as well as deal with the molecular mechanism as microenvironment, mechanistic effects, and gene expression. Application of collagen and HA have been reviewed in the area of orthopedics, orthopedics, ophthalmology, dermatology and plastic surgery. Finally, the ongoing and commercial products of collagen and HA for regenerative medicine have been introduced...
2018: Advances in Experimental Medicine and Biology
Hatice Ercan, Serap Durkut, Aysel Koc-Demir, Ayşe Eser Elçin, Yaşar Murat Elçin
Regenerative medicine is an interdisciplinary field that aims to regenerate the lost or diseased tissues through the combinational use of cells, biomolecules and/or biomaterials. Injectable biomaterials have been comprehensively evaluated for use in this field for their prominent properties, such as ease of handling, providing a better integration of the native tissue by filling irregular defects and having controllable chemical and physical properties. This class of biomaterials can be developed from natural or synthetic origin materials, decellularized matrices or from combinations of materials to form composites...
2018: Advances in Experimental Medicine and Biology
Yue Sa, Fang Yang, Yining Wang, Joop G C Wolke, John A Jansen
Even with the emerging of newly-developed bone substitutes, poly(methyl methacrylate) (PMMA) cement is still a widely-used bone replacing biomaterial in orthopedic surgery with a long history. However, aseptic loosening, infection of the prosthesis and thermal necrosis to surrounding tissue are the common complications of PMMA. Therefore, additives have been incorporated in PMMA cement to target those problems. This chapter summarizes different additives to improve the performance of the PMMA cement, i.e.: (1) bioceramic additives; (2) filler additives; (3) antibacterial additives; (4) porogens; (5) biological agents, and (6) mixed additives...
2018: Advances in Experimental Medicine and Biology
Mariana Baroni Selim, Fernanda Silveira Nóbrega, Lara Lopes Facó, Stefano Carlo Filippo Hagen, André Luís do Valle De Zoppa, Victor Elias Arana Chavez, Luciana Corrêa
OBJECTIVE:  The main purpose of this study was to evaluate the characteristics of a vegetal polymeric biomaterial intended for bone substitution in horses and to investigate the responses of the equine third metacarpal bone to biomaterial implantation. MATERIALS AND METHODS:  Six horses were submitted to osteotomy on the dorsal aspect of the left and right third metacarpal bones; one bone defect was randomly selected for treatment with biopolymer, while the other was left untreated and served as a control...
November 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
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