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biomaterials in surgery

Jennifer H Shepherd, Daniel Howard, Amie K Waller, Holly Rebecca Foster, Annett Muller, Thomas Moreau, Amanda L Evans, Meera Arumugam, Guénaëlle Bouët Chalon, Eleonora Vriend, Natalia Davidenko, Cedric Ghevaert, Serena M Best, Ruth E Cameron
Platelet transfusions are a key treatment option for a range of life threatening conditions including cancer, chemotherapy and surgery. Efficient ex vivo systems to generate donor independent platelets in clinically relevant numbers could provide a useful substitute. Large quantities of megakaryocytes (MKs) can be produced from human pluripotent stem cells, but in 2D culture the ratio of platelets harvested from MK cells has been limited and restricts production rate. The development of biomaterial cell supports that replicate vital hematopoietic micro-environment cues are one strategy that may increase in vitro platelet production rates from iPS derived Megakaryocyte cells...
August 8, 2018: Biomaterials
Jose A Moreno Rodriguez, Raúl G Caffesse
A new surgical approach has been developed to optimize the preservation of the gingival margin and papillae when treating periodontal defects. The flap is raised by one mucosal incision far away from the marginal tissues. This case series reports on the effectiveness of a nonincised surgical approach (NIPSA) in conjunction with a hydroxyapatite-based graft biomaterial and enamel matrix derivative in treating intrabony defects. Ten defects in 10 patients were treated. The follow-up period ranged from 6 to 18 months (mean: 10...
2018: International Journal of Periodontics & Restorative Dentistry
Roel F M R Kersten, Gang Wu, Behdad Pouran, Albert J van der Veen, Harrie H Weinans, Arthur de Gast, F Cumhur Öner, Steven M van Gaalen
Polyetheretherketone (PEEK) is commonly used as a spinal spacer for intervertebral fusion surgery. Unfortunately, PEEK is bioinert and does not effectively osseointegrate into living bone. In contrast, comparable spacers made of silicon nitride (Si3 N4 ) possess a surface nanostructure and chemistry that encourage appositional bone healing. This observational study was designed to compare the outcomes of these two biomaterials when implanted as spacers in an adult caprine model. Lumbar interbody fusion surgeries were performed at two adjacent levels in eight adult goats using implants of PEEK and Si3 N4 ...
August 9, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Timur Fatkhudinov, Larisa Tsedik, Irina Arutyunyan, Anastasia Lokhonina, Andrey Makarov, Aleksey Korshunov, Andrey Elchaninov, Evgeniya Kananykhina, Olesya Vasyukova, Natalia Usman, Elena Uvarova, Vladimir Chuprynin, Irina Eremina, Dmitry Degtyarev, Gennady Sukhikh
The objective of this study was to evaluate physical, mechanical, and biological properties of the polydioxanone (PDO) monofilament meshes and polyglycolide (PGA) polyfilament meshes in comparison with Permacol® implants. In rat experimental model, a 1.5 × 2.0 cm defect in abdominal wall was reconstructed by using the Permacol surgical implant or knitted meshes produced from either PDO monofilament, or PGA multifilament. The implant sites were assessed for the tensile strength and the extents of material resorption, host inflammatory response and host tissue replacement on days 3, 10, 30, or 60 after the surgery...
August 9, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Pia M Vidal, Antigona Ulndreaj, Anna Badner, James Hong, Michael G Fehlings
BACKGROUND: Degenerative cervical myelopathy (DCM) is caused by degenerative or congenital changes to the discs and soft tissues of the cervical spine, which leads to chronic compression of the spinal cord. The current treatment for moderate to severe DCM consists of surgical decompression, which, while effective in most cases, can result in neuroinflammation and spinal cord reperfusion injury, leading to perioperative neurological complications and suboptimal neurological recovery. The primary objective of this study was to assess, in a translationally relevant animal model of DCM, the efficacy of perioperative methylprednisolone (MP) in enhancing neurological recovery and to evaluate its effect on the inflammatory response following decompression...
August 6, 2018: Journal of Neuroinflammation
Seyedali Seyedmajidi, Ramazan Rajabnia, Maryam Seyedmajidi
AIMS AND OBJECTIVES: Infection is a serious problem for patients after implantation surgery, which is difficult to treat with antibiotic therapy. The present study was developed to evaluate and compare the antibacterial properties of hydroxyapatite/bioactive glass (HA/BG) and fluorapatite/bioactive glass (FA/BG) nanocomposite foams as a cellular scaffold for use in bone defects by two macrodilution and disk diffusion methods. MATERIALS AND METHODS: Staphylococcus aureus, Enterococcus faecalis , and Streptococcus mutans were cultured in brain heart infusion broth medium with nanocomposite powder for 5 days, and their bioactivity levels were evaluated by daily culturing on solid agar medium plates...
July 2018: Journal of Laboratory Physicians
João F Crispim, Sai C Fu, Yuk W Lee, Hugo A M Fernandes, Pascal Jonkheijm, Patrick S H Yung, Daniël B F Saris
BACKGROUND: The anterior cruciate ligament (ACL) has poor regenerative capacity, and an injury leads to loss of function, limiting quality of life and increasing the incidence of osteoarthritis. Surgical interventions can stabilize the joint and improve functional recovery. The delivery of growth factors (GFs) enhances the healing process; however, this is complex in its regulation, is high in costs, has side effects, and can only be accomplished with supraphysiological concentrations and thus is currently not clinically feasible...
August 3, 2018: American Journal of Sports Medicine
Sandro M Sgrott, Rodrigo D Neves, Armando J D'Acampora, Geraldo J S Bernardes, Luiz Belmonte, Thiago C Martins, Franciane Bobinski, Eduardo Cargnin-Ferreira, Andreza Hoepers, Clarissa M Comim, Daniel F Martins, Anna P Piovezan
Silicone breast implant is associated with complications inherent to the surgical procedure. Prosthesis coating with polyurethane, however, commonly reduces the incidence of such complications. In this paper, the authors evaluated the inflammatory histomorphometric profile and oxidative damage associated to the implant of polyester urethane sheets. Forty-eight Wistar rats were divided into Sham or polyester urethane groups (n = 8/group) and underwent a polyester urethane implant in the dorsal skinfold. Tissue samples were collected on days seven, 30, and 90 after surgery and subjected to histomorphometric analysis and biochemical tests...
July 26, 2018: Anais da Academia Brasileira de Ciências
Paula Fratini, Nathia Nathaly Rigoglio, Gustavo de Sá Schiavo Matias, Ana Claudia O Carreira, Rose Eli Grassi Rici, Maria Angelica Miglino
Regenerative medicine has been growing because of the emergent need for tissues/organs for transplants and restorative surgeries. Biological scaffolds are important tools to try to solve this problem. The one used in this reserach was developed by an acellular biological scaffold from canine placenta with a rich source of cellular matrix. After decellularization, the cellular matrix demonstrated structural preservation with the presence of important functional proteins such as collagen, fibronectin, and laminin...
2018: BioResearch Open Access
E Yu Pshenichnyuk, A V Asaturova, L V Adamyan, N V Zaytsev
OBJECTIVE: To investigate the expression of proliferation and apoptotic factors (Ki-67, Bcl-2), inflammatory factors (NF-kβ p65, COX-2), adhesion factors (β-catenin), estrogen (ER-α) and progesterone receptors (PR-α) in ovarian endometrioma (OE) in patients with recurrent OE by an immunohistochemical assay. SUBJECT AND METHODS: This investigation enrolled 48 reproductive-aged patients with OE. According to the course of the disease during a follow-up period of 1...
2018: Arkhiv Patologii
Gerardo La Monaca, Giovanna Iezzi, Maria Paola Cristalli, Nicola Pranno, Gian Luca Sfasciotti, Iole Vozza
Objectives: To evaluate the performances of six different bone substitute materials used as graft in maxillary sinus augmentation by means of histological and histomorphometric analysis of bone biopsies retrieved from human subjects after a 6-month healing period. Materials and Methods: Six consecutive patients (3 males, 3 females, aged 50-72 years), healthy, nonsmokers, and with good oral hygiene, presenting edentulous posterior maxilla with a residual bone crest measuring ≤ 4 mm in vertical height and 3 to 5 mm in horizontal thickness at radiographic examination, were selected to receive sinus augmentation and delayed implant placement...
2018: BioMed Research International
Consuelo C Zumarán, Marcelo V Parra, Sergio A Olate, Eduardo G Fernández, Francisco T Muñoz, Ziyad S Haidar
Platelet-Rich fibrin (PRF) is a three-dimensional (3-D) autogenous biomaterial obtained via simple and rapid centrifugation from the patient's whole blood samples, without including anti-coagulants, bovine thrombin, additives, or any gelifying agents. At the moment, it is safe to say that in oral and maxillofacial surgery, PRFs (particularly, the pure platelet-rich fibrin or P-PRF and leukocyte and platelet-rich fibrin or L-PRF sub-families) are receiving the most attention, essentially because of their simplicity, cost-effectiveness, and user-friendliness/malleability; they are a fairly new "revolutionary" step in second-generation therapies based on platelet concentration, indeed...
July 26, 2018: Materials
Lihong Lei, Yuanyuan Yu, Ting Ke, Weilian Sun, Lili Chen
A 36-year-old male patient diagnosed with severe chronic periodontitis was treated with novel surgery for his maxillary right lateral incisor. Preoperatively, a 3D printer was used to produce a photosensitive resin bony anatomy replica based on CBCT datasets. The patient's blood was centrifuged to obtain advanced platelet-rich fibrin (A-PRF) and Injected platelet-rich fibrin (I-PRF), which were mixed with Bio-Oss, and packed onto the 3D replica to form the ideal shape. The replica was then positioned at the planned sites without any change...
July 25, 2018: Journal of Oral Implantology
Surinder S Moonga, Yi-Xian Qin
Background: Low-intensity pulsed ultrasound (LIPUS) has been used in both basic research and clinical settings for its therapeutic potential in promoting tissue healing. Clinical data has shown that LIPUS can accelerate fresh fracture healing. However, the treatment for aging osteoporosis and non-union is still unclear. In addition, the mechanism of ultrasound promoted bone healing has remained unknown. Objective: It is proposed that noninvasive ultrasound treatment can enhance local fluid flow within the tissue to initiate remodeling and regeneration...
July 2018: Journal of Orthopaedic Translation
Janis Zarins, Mara Pilmane, Elga Sidhoma, Ilze Salma, Janis Locs
Strontium (Sr) has shown effectiveness for stimulating bone remodeling. Nevertheless, the exact therapeutic values are not established yet. Authors hypothesized that local application of Sr-enriched ceramics would enhance bone remodeling in constant osteoporosis of rabbits' femoral neck bone. Seven different bone conditions were analyzed: ten healthy rabbits composed a control group, while other twenty underwent ovariectomy and were divided into three groups. Bone defect was filled with hydroxyapatite 30% (HAP) and tricalcium phosphate 70% (TCP) granules in 7 rabbits, 5% of Sr-enriched HAP/TCP granules in 7, but sham defect was left unfilled in 6 rabbits...
July 20, 2018: Journal of Materials Science. Materials in Medicine
Mei Li, Weidan Wang, Ye Zhu, Yao Lu, Peng Wan, Ke Yang, Yu Zhang, Chuanbin Mao
Giant Cell Tumors of Bone (GCTB) are benign but aggressive and metastatic tumors. Surgical removal cannot eradicate GCTB due to the subsequent recurrence and osteolysis. Here we developed Zoledronic acid (ZA)-loaded magnesium-strontium (Mg-Sr) alloys that can inhibit GCTB and studied the molecular and cellular mechanisms of such inhibition. We first formed a calcium phosphate (CaP) coating on the Mg-1.5 wt%Sr implants by coprecipitation and then loaded ZA on the CaP coating. We examined the response of GCTB cells to the ZA-loaded alloys...
July 17, 2018: Acta Biomaterialia
Jan Borys, Mateusz Maciejczyk, Bożena Antonowicz, Adam Krętowski, Danuta Waszkiel, Piotr Bortnik, Katarzyna Czarniecka-Bargłowska, Magdalena Kocisz, Julita Szulimowska, Marek Czajkowski, Napoleon Waszkiewicz, Anna Zalewska
Due to the high biotolerance, favourable mechanical properties, and osseointegration ability, titanium is the basic biomaterial used in maxillofacial surgery. The passive layer of titanium dioxide on the surface of the implant effectively provides anticorrosive properties, but it can be damaged, resulting in the release of titanium ions to the surrounding tissues. The aim of our work was to evaluate the influence of Ti6Al4V titanium alloy on redox balance and oxidative damage in the periosteum surrounding the titanium miniplates and screws as well as in plasma and erythrocytes of patients with mandibular fractures...
2018: Oxidative Medicine and Cellular Longevity
Luigi Barbato, Niccolò Baldi, Alessio Gonnelli, Marco Duvina, Michele Nieri, Paolo Tonelli
The primary aim was to evaluate the association of patient related factors, biomaterials and implant characteristics on complications' rate of sinus graft surgery and on implant survival rate in grafted sinus. Secondary aims were to measure bone remodelling around implants and the patients' satisfaction. A retrospective cohort study was designed. Patients who had computer tomography before sinus surgery (T0), orthopantomography after implant surgery (T1) and at follow-up (T2), were included. Specific forms were used to collect clinical data...
July 16, 2018: Journal of Oral Implantology
Mariane Silva Pettian, Ana Maria de Guzzi Plepis, Virginia da Conceição Amaro Martins, Geovane Ribeiro Dos Santos, Clovis Antônio Lopes Pinto, Ewerton Alexandre Galdeano, Amanda Regina Alves Calegari, Carlos Alberto de Moraes, Marcelo Rodrigues da Cunha
Polymeric biomaterials composed of extracellular matrix components possess osteoconductive capacity that is essential for bone healing. The presence of collagen and the ability to undergo physicochemical modifications render these materials a suitable alternative in bone regenerative therapies. The objective of this study was to evaluate the osteogenic capacity of collagen-based matrices (native and anionic after alkaline hydrolysis) made from bovine intestinal serosa (MBIS). Twenty-five animals underwent surgery to create a cranial defect to be filled with native and anionic collagen matrixes, mmineralized and non mineralized...
2018: PloS One
Kingsfield Ong, Chin Siang Ong, Yang Chong Chua, Ali Akbar Fazuludeen, Aneez Dokeu Basheer Ahmed
Background: A plethora of new biomaterials and dedicated rib fixator implant systems have been introduced into the field of chest wall reconstruction. The aim of our study is to evaluate the surgical outcomes of a novel combination of the anatomically contoured titanium rib implant and porcine dermal collagen patch for chest wall reconstruction. Methods: We performed a retrospective review of eight consecutive patients who underwent chest wall resection and reconstruction between January 2014 to August 2015 in a single institution...
May 2018: Journal of Thoracic Disease
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