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https://www.readbyqxmd.com/read/30321816/adeno-associated-virus-mediated-rnai-against-mutant-alleles-attenuates-abnormal-calvarial-phenotypes-in-an-apert-syndrome-mouse-model
#1
Fengtao Luo, Yangli Xie, Zuqiang Wang, Junlan Huang, Qiaoyan Tan, Xianding Sun, Fangfang Li, Can Li, Mi Liu, Dali Zhang, Meng Xu, Nan Su, Zhenhong Ni, Wanling Jiang, Jinhong Chang, Hangang Chen, Shuai Chen, Xiaoling Xu, Chuxia Deng, Zhugang Wang, Xiaolan Du, Lin Chen
Apert syndrome (AS), the most severe form of craniosynostosis, is caused by missense mutations including Pro253Arg(P253R) of fibroblast growth factor receptor 2 (FGFR2), which leads to enhanced FGF/FGFR2-signaling activity. Surgical correction of the deformed skull is the typical treatment for AS. Because of constant maldevelopment of sutures, the corrective surgery is often executed several times, resulting in increased patient challenge and complications. Biological therapies targeting the signaling of mutant FGFR2 allele, in combination with surgery, may bring better outcome...
September 22, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/30321323/closed-vs-open-surgical-exposure-of-palatally-displaced-canines-surgery-time-postoperative-complications-and-patients-perceptions-a-multicentre-randomized-controlled-trial
#2
Margitha Björksved, Kristina Arnrup, Rune Lindsten, Anders Magnusson, Anna Lena Sundell, Annika Gustafsson, Farhan Bazargani
Background: Closed and open surgical techniques are two different main approaches to surgical exposure of palatally displaced canines (PDCs). Because there is insufficient evidence to support one technique over the other, there is a need for randomized controlled trials. Objectives: To compare surgery time, complications and patients' perceptions between closed and open surgical techniques in PDCs. Trial design: The trial was a multicentre, randomized, controlled trial with two parallel groups randomly allocated in a 1:1 ratio...
October 13, 2018: European Journal of Orthodontics
https://www.readbyqxmd.com/read/30320692/reconstruction-of-major-dehiscence-after-bilateral-cleft-lip-repair
#3
Elva Lim, Betty C J Pai, Daniel Getachew, Soyeon Jung, Lun-Jou Lo
Repair of complete bilateral cleft lip with protruding premaxilla is challenging, and postoperative dehiscence was common. Re-repair is usually suggested for the dehisced lip, but other methods might be needed in unique situations. Evaluation was performed to check the presence of prolabial skin, wound scarring, and the position of premaxilla. Reconstruction plan was made to restore the anatomical components as possible and to repair under minimal tension. Two patients with major dehiscence were reported. In the first case, separation from the columella base and tissue destruction in central lip were noted...
October 12, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/30320207/can-elastic-instability-be-beneficial-in-concentric-tube-robots
#4
Katherine E Riojas, Richard J Hendrick, Robert J Webster
Concentric tube manipulators exhibit elastic instability in which tubes snap from one configuration to another, rapidly releasing stored strain energy. While this has long been viewed as a negative phenomenon to be avoided at all costs, in this paper we explore for the first time whether the effect can be harnessed beneficially for certain applications. Specifically, we show that the energy released in an instability can be useful for challenging, high-force surgical tasks such as driving a needle through tissue...
July 2018: IEEE Robotics and Automation Letters
https://www.readbyqxmd.com/read/30318878/role-of-robotic-surgery-on-pelvic-floor-reconstruction
#5
Andrea Giannini, Eleonora Russo, Elisa Malacarne, Elena Cecchi, Paolo Mannella, Tommaso Simoncini
Over the past two decades, minimally invasive surgery (MIS) abdominal surgery has increasingly been used to treat pelvic organ prolapse. Besides the several advantages associated with minimal invasiveness, this approach bridged the gap between the benefits of vaginal surgery with the surgical success rates of open abdominal procedures. The most commonly performed procedure for suspension of the vaginal apex for postoperative vaginal prolapse by robotic-assisted laparoscopy is the sacrocolpopexy. Conventional laparoscopic application of this procedure was first reported in 1994 by Nezhat et al...
October 11, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/30318421/accuracy-and-trending-ability-of-the-fourth-generation-flotrac-ev1000-system-in-patients-with-severe-aortic-valve-stenosis-before-and-after-surgical-valve-replacement
#6
Andreas Eisenried, Raphael Klarwein, Harald Ihmsen, Andreas Wehrfritz, René Tandler, Christian Heim, Jörg Fechner
OBJECTIVE: Evaluate the accuracy and trending ability of the fourth-generation FloTrac/EV1000 (Edwards Lifesciences, Irvine, CA) system in patients with severe aortic valve stenosis by comparing FloTrac/EV1000-derived cardiac output (CCO-FT) with continuous thermodilution pulmonary artery catheter (CCO-PAC) measurements before and after surgical valve replacement. DESIGN: Prospective clinical study. SETTING: Anesthesia for cardiac surgery, operating room, single-center university hospital...
September 13, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/30318311/the-national-pediatric-surgery-simulation-program-in-france-a-tool-to-develop-resident-training-in-pediatric-surgery
#7
Jean Breaud, Isabelle Talon, Laurent Fourcade, Guillaume Podevin, Julien Rod, Georges Audry, Bruno Dohin, Jean-Francois Lecompte, Ronny Bensaid, Virginie Rampal, Georges Azzie
BACKGROUND/PURPOSE: To implement resident curriculum in France based on theoretical teaching and bed side training, the national council known as the "Collège Hospitalier et Universitaire de Chirurgie Pédiatrique" examined the relevance and feasibility of systematically introducing simulation program in the pediatric surgery resident training. MATERIAL AND METHODS: A national simulation training program was developed and took place in a 2-day session organized in 7 simulation centers in France...
September 21, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/30318274/tear-characteristics-and-surgeon-influence-repair-technique-and-suture-anchor-use-in-repair-of-superior-posterior-rotator-cuff-tendon-tears
#8
Kathleen A Derwin, Sambit Sahoo, Alexander Zajichek, Gregory Strnad, Kurt P Spindler, Joseph P Iannotti, Eric T Ricchetti
BACKGROUND: The factors that associate with surgical decisions about repair technique and the number of suture anchors used in rotator cuff repair have not been previously investigated. This study investigated the extent to which patient, surgeon, and surgical factors associate with performing single-row vs. double-row repair technique and ultimately with the number of suture anchors used. METHODS: Our institution's prospective surgical cohort was queried for patients undergoing suture anchor repair of superior-posterior rotator cuff tendon tears between February 2015 and August 2017...
October 11, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/30317686/picosecond-laser-for-atrophic-surgical-scars-treatment-in-vivo-monitoring-of-results-by-means-of-reflectance-confocal-microscopy
#9
S Guida, P L Bencini, G Pellacani
Surgical excision can be followed by non-aesthetic scar development, despite the use of modern suture technique. Skin site involved is important since the location of scars in "aesthetic" sites, such as the face, can cause psychological problems for patients. In order to improve scar appearance, different therapeutic approaches have been employed. This article is protected by copyright. All rights reserved.
October 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30316445/laparoscopic-uterine-fixation-to-spare-fertility-before-pelvic-radiation-therapy
#10
Henri Azaïs, Charles-Henri Canova, Elie Vesale, Jean-Marc Simon, Geoffroy Canlorbe, Catherine Uzan
OBJECTIVE: To describe a surgical technique for laparoscopic uterine fixation (LUF) to decrease uterine radiation therapy side effects in case of rectal or anal cancer. DESIGN: This video article uses a surgical case to demonstrate the detailed technique. Institutional Review Board approval was not required for this video presentation. SETTING: University hospital. PATIENT(S): A 26-year-old nulliparous female patient diagnosed with rectal adenocarcinoma and liver metastases...
October 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/30315895/technique-for-tissue-containment-and-extraction-in-the-complex-minimally-invasive-myomectomy-setting
#11
Gaby N Moawad, Paul Tyan, Charbel Awad
STUDY OBJECTIVE: In this surgical tutorial, we present technical pointers and suggestions that would enable gynecologic surgeons to achieve difficult tissue containment and extraction for numerous and large myomas in the complex minimally invasive myomectomy setting. DESIGN: A step by-step explanation of the surgery using video (instructive video), exempt by the local Institutional Review Board. (Canadian Task Force classification level III). IRB approval was not required for this study...
October 10, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/30313086/a-morel-lavall%C3%A3-e-lesion-of-the-proximal-calf-in-a-young-trauma-patient-a-case-report
#12
Woo Jong Kim, Hong Seop Lee, Sung Hun Won, Yong Cheol Hong, Dhong Won Lee, Ji-Hye Lee, Chang Hyun Kim
RATIONALE: The Morel-Lavallée lesion (MLL) is a closed degloving injury developing when shear force acts between the muscle fascia and the subcutaneous layer. MLLs develop principally in the trochanteric area or the pelvis; lesions in the proximal calf are rare. Acute lesions can be treated conservatively, but chronic lesions are best treated surgically because of a high rate of recurrence. To the best of our knowledge, this is a rare case of successful treatment of an MLL in the proximal calf associated with tibio-fibular shaft fracture...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30312574/super-thick-amniotic-membrane-graft-for-ocular-surface-reconstruction
#13
Paul T Finger, Puneet Jain, Sri Krishna Mukkamala
PURPOSE: Evaluate Super-Thick Amniotic Membrane Graft(ST-AMG) for ocular surface reconstruction. DESIGN: Retrospective, interventional case series. METHODS: SETTING: Single center, clinical practice POPULATION: Selected patients with typically large ocular surface abnormalities that required reconstruction. INTERVENTION: Surgical insertion of ST-AMG for reconstruction or repair of the ocular surface. MAIN OUTCOME MEASURES: Intraoperative handling, graft position at 1 week post-implantation, graft dissolution at 3-weeks, epithelialization of the ocular surface and symblepharon...
October 9, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/30311604/the-degree-of-invasiveness-has-no-influence-on-the-rate-of-incidental-durotomies-in-surgery-for-lumbar-spinal-canal-stenosis-data-from-the-german-spine-registry
#14
Juan M Vinas-Rios, Fatima Medina-Govea, Viktor von Beeg-Moreno, Frerk Meyer
BACKGROUND: Risk factors for incidental durotomies are good documented claimed from some authors the degree of invasiveness as a direct risk factor on this serious complication. We compared the rate of incidental durotomies and its dependence from the degree of invasiveness. METHODS: The German Spine Registry could document 6016 surgeries for lumbar spinal canal stenosis, n= 2539 microsurgical decompression and n= 2371 open decompression with stabilization. RESULTS: Both groups were identical concerning age and sex of patients: mean age 77,1 ± 1,60, female 58%, male 32%...
October 10, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/30310839/penetrating-shrapnel-injury-to-the-chest-presenting-as-a-delayed-tracheoesophageal-fistula-tef-a-case-report
#15
Hasan Al Harakeh, Tamam Tulimat, Pierre Sfeir, Ali Hallal
Tracheo-esophageal fistulae (TEF) due to trauma are rare. We report a case of a delayed TEF caused by a shrapnel from a blast. A 25-year-old male was admitted to the hospital after sustaining a blast injury. A contrast CT scan of the chest and neck revealed the presence of metallic shrapnel in close proximity to the tracheo-esophageal groove at the level of the thoracic inlet. Bronchoscopy revealed 0.5 cm tear in the membranous trachea while esophagoscopy and contrast swallow were normal. Coughs after starting fluid intake triggered a repeat endoscopy that showed a large TEF at 22 cm from the incisors...
October 2018: Trauma Case Reports
https://www.readbyqxmd.com/read/30310395/effects-of-carbon-dioxide-insufflation-on-anastomosis-remodeling-at-a-carotid-artery-site-in-rabbits
#16
Tuğra Gençpınar, Gökmen Akkaya, Çağatay Bilen, Pınar Akokay, Osman Yılmaz, Hudai Çatalyürek
Introduction: Use of carbon dioxide (CO2 ) insufflation (CDI) on the surgical field during heart surgery has become widespread, and in some units routine. Aim: To assess the effects of CDI on endothelial dysfunction in a carotid artery model in rabbits. Material and methods: Twelve randomly selected rabbits were divided into two groups. Right carotid arteries of the animals were transected and sutured with running suture technique. Then, 1 l/min CO2 insufflation was initiated with a 45° angle...
September 2018: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/30310028/-surgical-devices-for-minimally-invasive-cardiac-surgery-mics
#17
Yuji Kawano, Minoru Tabata
Minimally invasive cardiac surgery(MICS)rapidly has become popular in recent years. To perform meticulous surgical procedures in the limited space, specially designed surgical instruments are very useful. For excellent exposure of the surgical target, thoracoscopic system with high imaging quality such as 4K or 3D HD endoscopy is often used. An articulated rib spreader and/or soft tissue retractor is also useful since those instruments do not interfere with other surgical instruments. A suture catcher is used to pull traction sutures through the chest wall...
September 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/30309664/zone-i-flexor-digitorum-profundus-repair-a-surgical-technique
#18
REVIEW
Elizabeth M Polfer, Jennifer M Sabino, Ryan D Katz
We present an all-inside technique for zone I flexor tendon repair that combines suture anchor fixation with buried back-up fixation. The back-up fixation uses transosseous tunnels and a dorsal counterincision to allow a suture tied dorsal to the distal phalanx and buried. This technique is strong and permits early active range of motion. The dorsal tie-over does not require a suture button and, therefore, does not imperil the nail matrix. The surgical technique is herein described including the proposed anesthesia (wide awake), the incisions (midlateral), the exposures, and the repair itself...
October 8, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/30309351/continuous-or-interrupted-suture-technique-for-hepaticojejunostomy-a-national-survey
#19
Maximilian Brunner, Jessica Stockheim, Christian Krautz, Dimitrios Raptis, Stephan Kersting, Georg F Weber, Robert Grützmann
BACKGROUND: Hepaticojejunostomy is commonly used in hepato-bilio-pancreatic surgery and a crucial step in many surgical procedures, including pancreaticoduodenectomy. The most frequently used techniques are the interrupted suture and the continuous suture technique. Currently, there is no data available in regard to the utilization of these techniques. METHODS: In total, 102 hospitals in Germany were invited between September and November 2017 to participate in this survey...
October 11, 2018: BMC Surgery
https://www.readbyqxmd.com/read/30307366/laparoscopic-repair-for-groin-hernias-in-female-patients-a-single-center-experience-in-15-years
#20
Zirui He, Xiaohui Hao, Bo Feng, Jianwen Li, Jing Sun, Pei Xue, Fei Yue, Xialin Yan, Ji Wang, Minhua Zheng
BACKGROUND: Our objective was to investigate the clinical characteristics of laparoscopic repair for groin hernias in female patients. STUDY DESIGN: The clinical data of 316 female patients (341 hernias) who underwent laparoscopic inguinal hernia repair at Shanghai Minimally Invasive Surgery Center between January 2001 and December 2015 was analyzed retrospectively. The operation-related data were to provide an overview of female groin hernias, preferred surgical approach, and the management of round ligament of uterus...
October 9, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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