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Patricia Brasil

Suan-Sin Foo, Weiqiang Chen, Yen Chan, Wai-Suet Lee, Shin-Ae Lee, Genhong Cheng, Karin Nielsen-Saines, Patrícia Brasil, Jae U Jung
BACKGROUND: An intricate fetal-maternal immune crosstalk during pregnancy is essential for a healthy birth. Hence, the infection-induced alterations of maternal immunity often lead to adverse outcomes for mother and/or child. The emergence of Zika virus (ZIKV) infection in pregnant women has been associated with more than 3,000 cases of microcephaly and nervous system malformations. METHODS: To explore the potential correlation of ZIKV-induced alteration of maternal immunity with fetal abnormalities, we performed extensive sera immunoprofiling of 74 pregnant women: 30 symptomatic ZIKV+ pregnant patients and 30 healthy pregnant controls in ZIKV-endemic Rio de Janeiro, along with 14 healthy pregnant controls in non-endemic Los Angeles...
November 2, 2018: JCI Insight
Andrea A Zin, Irena Tsui, Julia D Rossetto, Stephanie L Gaw, Luiza M Neves, Olivia A Zin, Lorena Haefeli, Joel Carlos Barros Silveira Filho, Kristina Adachi, Marcos Vinicius da Silva Pone, Sheila Moura Pone, Natalia Molleri, Jose Paulo Pereira, Rubens Belfort, Vaithilingaraja Arumugaswami, Zilton Vasconcelos, Patricia Brasil, Karin Nielsen-Saines, Maria Elisabeth Lopes Moreira
PURPOSE: To report the findings of a cross-sectional study of visual function in infants with confirmed or suspected antenatal Zika virus (ZIKV) infection seen at a single referral center in Rio de Janeiro. METHODS: Infants were examined following the ZIKV outbreak period at Fernandes Figueira Institute/FIOCRUZ. Visual function was considered abnormal if an infant could not fix and follow a standardized high-contrast target (10 cm) by 3-6 months of age. Visual function and associations with structural eye abnormalities, central nervous system (CNS) abnormalities, microcephaly, and nystagmus were assessed...
October 22, 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Kathleen M O'Reilly, Rachel Lowe, W John Edmunds, Philippe Mayaud, Adam Kucharski, Rosalind M Eggo, Sebastian Funk, Deepit Bhatia, Kamran Khan, Moritz U G Kraemer, Annelies Wilder-Smith, Laura C Rodrigues, Patricia Brasil, Eduardo Massad, Thomas Jaenisch, Simon Cauchemez, Oliver J Brady, Laith Yakob
BACKGROUND: Zika virus (ZIKV) emerged in Latin America and the Caribbean (LAC) region in 2013, with serious implications for population health in the region. In 2016, the World Health Organization declared the ZIKV outbreak a Public Health Emergency of International Concern following a cluster of associated neurological disorders and neonatal malformations. In 2017, Zika cases declined, but future incidence in LAC remains uncertain due to gaps in our understanding, considerable variation in surveillance and the lack of a comprehensive collation of data from affected countries...
October 3, 2018: BMC Medicine
Filipe Vieira Santos de Abreu, Larissa Rodrigues Gomes, Aline Rosa Lavigne Mello, Cesare Bianco-Júnior, Anielle de Pina-Costa, Edmilson Dos Santos, Danilo Simonini Teixeira, Patrícia Brasil, Cláudio Tadeu Daniel-Ribeiro, Ricardo Lourenço-de-Oliveira, Maria de Fátima Ferreira-da-Cruz
BACKGROUND: Zoonotic infections with epidemic potential, as non-human primate malaria and yellow fever (YF), can overlap geographically. Optimizing a small blood sample for diagnosis and surveillance is of great importance. Blood are routinely collected for YF diagnosis and blood clots usually discarded after serum obtention. Aiming to take sample advantage, the sensitivity of a PCR using extracted DNA from long-term frozen clots from human and non-human primates for detection of Plasmodium spp...
September 24, 2018: Malaria Journal
Irena Tsui, Maria Elisabeth Lopes Moreira, Julia D Rossetto, Zilton Vasconcelos, Stephanie L Gaw, Luiza M Neves, Olivia A Zin, Lorena Haefeli, Joel Carlos Barros Silveira Filho, Saint Clair Gomes, Kristina Adachi, Marcos Vinicius da Silva Pone, Sheila Moura Pone, Jose Paulo Pereira, Rubens Belfort, Vaithilingaraja Arumugaswami, Patricia Brasil, Karin Nielsen-Saines, Andrea A Zin
: media-1vid110.1542/5804915134001PEDS-VA_2018-1104 Video Abstract OBJECTIVES: To characterize ophthalmic manifestations of confirmed or suspected antenatal Zika virus (ZIKV) exposure. METHODS: Infants with antenatal ZIKV exposure were referred for evaluation during the 2015-2016 Rio de Janeiro outbreak. Mothers with symptomatic ZIKV infection during pregnancy and/or infants with microcephaly or other findings that were suggestive of suspected antenatal exposure were tested with reverse transcriptase polymerase chain reaction (RT-PCR)...
October 2018: Pediatrics
Maria Fernanda de Moura Leão, Jonathaline Apollo Duarte, Patrícia Dutra Sauzen, Jacqueline da Costa Escobar Piccoli, Luís Flávio Souza de Oliveira, Michel Mansur Machado
Hypertension, a chronic non-transmissible multifactorial condition, it is highly frequent in Brazil, affecting about 32.5% of the population over 25 years of age. It is characterized by the sustained increase in systolic and diastolic blood pressure levels above 140 mmHg and 90 mmHg, respectively. It is the major aggravating factor in cardiovascular complications and the appearance of other comorbidities. Aiming to promote greater adherence to treatment and improve the population's access to basic medicament, in 2004 the Federal Government created the Programa Farmácia Popular do Brasil (PFPB); partnership with private institutions that provides the population with medicament to control hypertension, free of charge or subsidized at up to 90% of the value...
October 2018: Environmental Toxicology and Pharmacology
Larissa Rodrigues Gomes, Aline Lavigne, Cassio Leonel Peterka, Patrícia Brasil, Didier Ménard, Cláudio Tadeu Daniel-Ribeiro, Maria de Fátima Ferreira-da-Cruz
Plasmodium falciparum artemisinin-resistant parasites can be evaluated by examining polymorphisms in the kelch ( PfK13 ) domain. A total of 69 samples from patients with falciparum malaria were analyzed. All samples were from areas in states in Brazil where the parasite was endemic: Acre ( n = 14), Amapá ( n = 15), Amazonas ( n = 30), and Pará ( n = 10). After DNA alignment with the 3D7 reference sequence, all samples were found to be wild type. These data provide a baseline for PfK13 and reinforce the pertinence of artemisinin combination therapy in Brazilian areas...
October 2018: Antimicrobial Agents and Chemotherapy
Amanda Q Lemos, Cristina A Brasil, Cecília M Alvares, Jaqueline C G Passos, Patrícia Lordêlo, Katia N Sá
AIMS: To Compare the angular parameters of the pelvis of continents and incontinent women and to correlate them with the electrical activity and the function of the pelvic floor muscles. METHODS: Cross-sectional study. Incontinent and continent women, aged between 18 and 59 years. The anatomical points were marked following the SAPO protocols, the photographic records were made and analyzed through the SAPO Software. The evaluation of the function of the MPF was performed by bidigital vaginal palpation, using the PERFECT scheme...
November 2018: Neurourology and Urodynamics
Guilherme Amaral Calvet, Patricia Brasil, Andre Machado Siqueira, Heruza Einsfeld Zogbi, Bianca de Santis Gonçalves, Aline da Silva Santos, Otilia Lupi, Rogerio Valls de Souza, Cintia Damasceno Dos Santos Rodrigues, Clarisse da Silveira Bressan, Mayumi Duarte Wakimoto, Eliane Saraiva de Araújo, Ingrid Cardoso Dos Santos, Ingebourg Georg, Rita Maria Ribeiro Nogueira, Valdilea Gonçalves Veloso, Ana Maria Bispo de Filippis
BACKGROUND: Zika virus (ZIKV) emergence in South America revealed the lack of knowledge regarding clinical manifestations in HIV-infected individuals. OBJECTIVES: We described the clinical characteristics, laboratory manifestations, differential diagnosis, and outcome of ZIKV infection in a large, single-center cohort of HIV-infected patients. METHODS: HIV-infected patients aged 18 years and older with clinical suspected arboviral disease from an ongoing cohort were followed from February 2015 through December 2015...
October 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
J Moreira, C S Bressan, P Brasil, A M Siqueira
BACKGROUND: The causes of acute febrile illness (AFI) in Latin America are diverse and their complexity increases as the proportion of fever due to malaria decreases, as malaria control measures and new pathogens emerge in the region. In this context, it is important to shed light on the gaps in the epidemiological characteristics and the geographic range for many AFI aetiologies. OBJECTIVES: To review studies on community-acquired fever aetiology other than malaria in Latin America, and to highlight knowledge gaps and challenges needing further investigation...
August 2018: Clinical Microbiology and Infection
Edson Delatorre, Milene Miranda, Diogo A Tschoeke, Patrícia Carvalho de Sequeira, Simone Alves Sampaio, Giselle Barbosa-Lima, Yasmine Rangel Vieira, Luciana Leomil, Fernando A Bozza, José Cerbino-Neto, Patricia T Bozza, Rita Maria Ribeiro Nogueira, Patrícia Brasil, Fabiano L Thompson, Ana M B de Filippis, Thiago Moreno L Souza
Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine)...
May 17, 2018: Journal of General Virology
Tania Ayllón, Daniel Cardoso Portela Câmara, Fernanda Cristina Morone, Larissa da Silva Gonçalves, Fábio Saito Monteiro de Barros, Patrícia Brasil, Marilia Sá Carvalho, Nildimar Alves Honório
Aedes albopictus, originally considered as a secondary vector for arbovirus transmission, especially in areas where this species co-exist with Aedes aegypti, has been described in most regions of the world. Dispersion and domiciliation of Ae. albopictus in a complex of densely urbanized slums in Rio de Janeiro, Southeastern Brazil, was evidenced. In this study, we tested the hypotheses that 1) Ae. albopictus distribution in urban slums is negatively related to distance from vegetation, and 2) these vectors have taken on a domestic life style with a portion of the population feeding, ovipositing, and resting indoors...
2018: PloS One
Patricia de Oliveira da Silva, Joanna Miguez Nery Guimarães, Rosane Härter Griep, Enirtes Caetano Prates Melo, Sheila Maria Alvim Matos, Maria Del Carmem Molina, Sandhi Maria Barreto, Maria de Jesus Mendes da Fonseca
This study investigated whether the association between body image dissatisfaction and poor self-rated health is mediated by insufficient physical activity and unhealthy eating habits. The participants were 6727 men and 8037 women from the baseline (2008–2010) of the Longitudinal Study of Adult Health (Estudo Longitudinal de Saúde do Adulto, ELSA-Brasil). Structural equation modelling was used. Associations were found between body image dissatisfaction and poor self-rated health in both sexes...
April 18, 2018: International Journal of Environmental Research and Public Health
Lusiele Guaraldo, Mayumi Duarte Wakimoto, Heloisa Ferreira, Clarisse Bressan, Guilherme Amaral Calvet, Geraldo Castelar Pinheiro, Andre Machado Siqueira, Patrícia Brasil
Chikungunya virus is amongst the fastest expanding vector transmissible diseases in recent years and has been causing massive epidemics in Africa, Asia, Latin America and the Caribbean. Despite human infection by this virus being first described in the 1950s, there is a lack of adequate therapeutic evaluations to guide evidence-based recommendations. The current guidelines rely heavily in specialists' opinion and experience instead of using higher rated evidence. Areas covered: A systematic review of the literature was performed- not restricted to clinical trials - reporting the therapeutic response against this infection with the intent to gather the best evidence of the treatment options against musculoskeletal disorders following chikungunya fever...
April 2018: Expert Review of Anti-infective Therapy
Patrícia Miranda Mendes, Aline Araújo Nobre, Rosane Härter Griep, Joanna Miguez Nery Guimarães, Leidjaira Lopes Juvanhol, Sandhi Maria Barreto, Alexandre Pereira, Dóra Chor
"Pardos" and blacks in Brazil and blacks in the USA are at greater risk of developing arterial hypertension than whites, and the causes of this inequality are still little understood. Psychosocial and contextual factors, including racial discrimination, are indicated as conditions associated with this inequality. The aim of this study was to identify the association between perceived racial discrimination and hypertension. The study evaluated 14,012 workers from the ELSA-Brazil baseline population...
March 1, 2018: Cadernos de Saúde Pública
Ravi Mehta, Cristiane Nascimento Soares, Raquel Medialdea-Carrera, Mark Ellul, Marcus Tulius Texeira da Silva, Anna Rosala-Hallas, Marcia Rodrigues Jardim, Girvan Burnside, Luciana Pamplona, Maneesh Bhojak, Radhika Manohar, Gabriel Amorelli Medeiros da Silva, Marcus Vinicius Adriano, Patricia Brasil, Rita Maria Ribeiro Nogueira, Carolina Cardoso Dos Santos, Lance Turtle, Patricia Carvalho de Sequeira, David W Brown, Michael J Griffiths, Ana Maria Bispo de Filippis, Tom Solomon
BACKGROUND: During 2015-16 Brazil experienced the largest epidemic of Zika virus ever reported. This arthropod-borne virus (arbovirus) has been linked to Guillain-Barré syndrome (GBS) in adults but other neurological associations are uncertain. Chikungunya virus has caused outbreaks in Brazil since 2014 but associated neurological disease has rarely been reported here. We investigated adults with acute neurological disorders for Zika, chikungunya and dengue, another arbovirus circulating in Brazil...
February 2018: PLoS Neglected Tropical Diseases
Guilherme Amaral Calvet, Edna Oliveira Kara, Silvana Pereira Giozza, Camila Helena Aguiar Bôtto-Menezes, Philippe Gaillard, Rafael Freitas de Oliveira Franca, Marcus Vinicius Guimarães de Lacerda, Marcia da Costa Castilho, Patrícia Brasil, Patrícia Carvalho de Sequeira, Maeve Brito de Mello, Ximena Pamela Diaz Bermudez, Kayvon Modjarrad, Robyn Meurant, Sihem Landoulsi, Adele Schwartz Benzaken, Ana Maria Bispo de Filippis, Nathalie Jeanne Nicole Broutet
BACKGROUND: Zika virus (ZIKV) has been identified in several body fluids of infected individuals. In most cases, it remained detected in blood from few days to 1 week after the onset of symptoms, and can persist longer in urine and in semen. ZIKV infection can have dramatic consequences such as microcephaly and Guillain-Barré syndrome. ZIKV sexual transmission has been documented. A better understanding of ZIKV presence and persistence across biologic compartments is needed to devise rational measures to prevent its transmission...
January 22, 2018: BMC Infectious Diseases
Sheila Moura Pone, Yara Hahr Marques Hökerberg, Patricia Brasil, Cecília Carmen de Araújo Nicolai, Rogério Ferrari, Raquel de Vasconcellos Carvalhaes de Oliveira
In 2007-2008, the city of Rio de Janeiro underwent an epidemiological change, with increases in the incidence in children and in severe forms of dengue. To describe the clinical profile and spatial distribution of dengue we performed an ecological study based on dengue surveillance data using the Brazilian classification (2005): dengue fever, dengue haemorrhagic fever (DHF) and dengue with complications. χ 2 test was used to describe the clinical and socio-demographic variables (P < 0.05). Spatial distribution of incidence and case-fatality was explored with thematic maps, Moran and Geary indices (P < 0...
February 2018: Epidemiology and Infection
Gilvânia Patrícia do Nascimento Paixão, Alvaro Pereira, Nadirlene Pereira Gomes, Anderson Reis de Sousa, Fernanda Matheus Estrela, Ubirajara Ramos Pereira da Silva Filho, Igor Brasil de Araújo
OBJECTIVE: to analyze male criminals' perception about marital violence. METHOD: An exploratory, descriptive, qualitative study undertaken with 23 men who were criminally prosecuted for marital violence. A multimethod data collection was conducted, with individual interview and focal group techniques combined, between May and December 2015. The data collected were initially categorized using the NVIVO® 11 software program, and then organized using the Collective Subject Discourse method...
2018: Revista Brasileira de Enfermagem
Rachel Lowe, Christovam Barcellos, Patrícia Brasil, Oswaldo G Cruz, Nildimar Alves Honório, Hannah Kuper, Marilia Sá Carvalho
The first confirmed case of Zika virus infection in the Americas was reported in Northeast Brazil in May 2015, although phylogenetic studies indicate virus introduction as early as 2013. Zika rapidly spread across Brazil and to more than 50 other countries and territories on the American continent. The Aedes aegypti mosquito is thought to be the principal vector responsible for the widespread transmission of the virus. However, sexual transmission has also been reported. The explosively emerging epidemic has had diverse impacts on population health, coinciding with cases of Guillain-Barré Syndrome and an unexpected epidemic of newborns with microcephaly and other neurological impairments...
January 9, 2018: International Journal of Environmental Research and Public Health
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