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Patricia Brasil

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https://www.readbyqxmd.com/read/30061292/absence-of-k13-polymorphism-in-plasmodium-falciparum-parasites-from-brazilian-endemic-areas
#1
Larissa Rodrigues Gomes, Aline Lavigne, Cassio Leonel Peterka, Patrícia Brasil, Didier Ménard, Cláudio Tadeu Daniel-Ribeiro, Maria de Fátima Ferreira-da-Cruz
P. falciparum ART-resistant parasites can be evaluated examining polymorphisms in the Kelch ( PfK13 ) domain. 69 samples from falciparum malaria patients were analyzed. All samples were from Brazilian endemic areas of the following states: Acre (n=14), Amapá (n=15), Amazonas (n=30) and Pará (n=10). After DNA alignment with the 3D7 reference sequence all samples were found to be wild-type. These data provide a baseline on PfK13 and reinforce the pertinence of ACTs treatment in Brazilian areas.
July 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/30024050/the-relation-of-the-pelvis-and-the-perineal-function-in-incontinent-women-a-neglected-subject
#2
Amanda Q Lemos, Cristina A Brasil, Cecília M Alvares, Jaqueline C G Passos, Patrícia Lordêlo, Katia N Sá
AIMS: To Compare the angular parameters of the pelvis of continents and incontinent women and to correlate them with the electrical activity and the function of the pelvic floor muscles. METHODS: Cross-sectional study. Incontinent and continent women, aged between 18 and 59 years. The anatomical points were marked following the SAPO protocols, the photographic records were made and analyzed through the SAPO Software. The evaluation of the function of the MPF was performed by bidigital vaginal palpation, using the PERFECT scheme...
July 19, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29912006/zika-virus-infection-and-differential-diagnosis-in-a-cohort-of-hiv-infected-patients
#3
Guilherme Amaral Calvet, Patricia Brasil, Andre Machado Siqueira, Heruza Einsfeld Zogbi, Bianca de Santis Gonçalves, Aline da Silva Santos, Otilia Lupi, Rogerio Valls de Souza, Cintia Damasceno Dos Santos Rodrigues, Clarisse da Silveira Bressan, Mauymi Duarte Wakimoto, Eliane Saraiva de Araújo, Ingrid Cardoso Dos Santos, Ingebourg Georg, Rita Maria Ribeiro Nogueira, Valdilea Gonçalves Veloso, Ana Maria Bispo de Filippis
BackgroundZika virus (ZIKV) emergence in South America revealed the lack of knowledge regarding clinical manifestations in HIV-infected individuals. OBJECTIVES: We described the clinical characteristics, laboratory manifestations, differential diagnosis, and outcome of ZIKV infection in a large, single-center cohort of HIV-infected patients.MethodsHIV-infected patients aged ≥ 18 years with clinical suspected arboviral disease from an ongoing cohort were followed from February through December 2015...
June 14, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29777926/epidemiology-of-acute-febrile-illness-in-latin-america
#4
REVIEW
J Moreira, C S Bressan, P Brasil, A M Siqueira
BACKGROUND: The causes of acute febrile illness (AFI) in Latin America are diverse and their complexity increases as the proportion of fever due to malaria decreases, as malaria control measures and new pathogens emerge in the region. In this context, it is important to shed light on the gaps in the epidemiological characteristics and the geographic range for many AFI aetiologies. OBJECTIVES: To review studies on community-acquired fever aetiology other than malaria in Latin America, and to highlight knowledge gaps and challenges needing further investigation...
August 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29771234/an-observational-clinical-case-of-zika-virus-associated-neurological-disease-is-associated-with-primary-igg-response-and-enhanced-tnf-levels
#5
Edson Delatorre, Milene Miranda, Diogo A Tschoeke, Patrícia Carvalho de Sequeira, Simone Alves Sampaio, Giselle Barbosa-Lima, Yasmine Rangel Vieira, Luciana Leomil, Fernando A Bozza, José Cerbino-Neto, Patricia T Bozza, Rita Maria Ribeiro Nogueira, Patrícia Brasil, Fabiano L Thompson, Ana M B de Filippis, Thiago Moreno L Souza
Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine)...
May 17, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29684029/dispersion-and-oviposition-of-aedes-albopictus-in-a-brazilian-slum-initial-evidence-of-asian-tiger-mosquito-domiciliation-in-urban-environments
#6
Tania Ayllón, Daniel Cardoso Portela Câmara, Fernanda Cristina Morone, Larissa da Silva Gonçalves, Fábio Saito Monteiro de Barros, Patrícia Brasil, Marilia Sá Carvalho, Nildimar Alves Honório
Aedes albopictus, originally considered as a secondary vector for arbovirus transmission, especially in areas where this species co-exist with Aedes aegypti, has been described in most regions of the world. Dispersion and domiciliation of Ae. albopictus in a complex of densely urbanized slums in Rio de Janeiro, Southeastern Brazil, was evidenced. In this study, we tested the hypotheses that 1) Ae. albopictus distribution in urban slums is negatively related to distance from vegetation, and 2) these vectors have taken on a domestic life style with a portion of the population feeding, ovipositing, and resting indoors...
2018: PloS One
https://www.readbyqxmd.com/read/29670031/association-between-body-image-dissatisfaction-and-self-rated-health-as-mediated-by-physical-activity-and-eating-habits-structural-equation-modelling-in-elsa-brasil
#7
Patricia de Oliveira da Silva, Joanna Miguez Nery Guimarães, Rosane Härter Griep, Enirtes Caetano Prates Melo, Sheila Maria Alvim Matos, Maria Del Carmem Molina, Sandhi Maria Barreto, Maria de Jesus Mendes da Fonseca
This study investigated whether the association between body image dissatisfaction and poor self-rated health is mediated by insufficient physical activity and unhealthy eating habits. The participants were 6727 men and 8037 women from the baseline (2008–2010) of the Longitudinal Study of Adult Health (Estudo Longitudinal de Saúde do Adulto, ELSA-Brasil). Structural equation modelling was used. Associations were found between body image dissatisfaction and poor self-rated health in both sexes...
April 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29533103/treatment-of-chikungunya-musculoskeletal-disorders-a-systematic-review
#8
Lusiele Guaraldo, Mayumi Duarte Wakimoto, Heloisa Ferreira, Clarisse Bressan, Guilherme Amaral Calvet, Geraldo Castelar Pinheiro, Andre Machado Siqueira, Patrícia Brasil
Chikungunya virus is amongst the fastest expanding vector transmissible diseases in recent years and has been causing massive epidemics in Africa, Asia, Latin America and the Caribbean. Despite human infection by this virus being first described in the 1950s, there is a lack of adequate therapeutic evaluations to guide evidence-based recommendations. The current guidelines rely heavily in specialists' opinion and experience instead of using higher rated evidence. Areas covered: A systematic review of the literature was performed- not restricted to clinical trials - reporting the therapeutic response against this infection with the intent to gather the best evidence of the treatment options against musculoskeletal disorders following chikungunya fever...
April 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29513825/association-between-perceived-racial-discrimination-and-hypertension-findings-from-the-elsa-brasil-study
#9
Patrícia Miranda Mendes, Aline Araújo Nobre, Rosane Härter Griep, Joanna Miguez Nery Guimarães, Leidjaira Lopes Juvanhol, Sandhi Maria Barreto, Alexandre Pereira, Dóra Chor
"Pardos" and blacks in Brazil and blacks in the USA are at greater risk of developing arterial hypertension than whites, and the causes of this inequality are still little understood. Psychosocial and contextual factors, including racial discrimination, are indicated as conditions associated with this inequality. The aim of this study was to identify the association between perceived racial discrimination and hypertension. The study evaluated 14,012 workers from the ELSA-Brazil baseline population...
March 1, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29432457/the-spectrum-of-neurological-disease-associated-with-zika-and-chikungunya-viruses-in-adults-in-rio-de-janeiro-brazil-a-case-series
#10
Ravi Mehta, Cristiane Nascimento Soares, Raquel Medialdea-Carrera, Mark Ellul, Marcus Tulius Texeira da Silva, Anna Rosala-Hallas, Marcia Rodrigues Jardim, Girvan Burnside, Luciana Pamplona, Maneesh Bhojak, Radhika Manohar, Gabriel Amorelli Medeiros da Silva, Marcus Vinicius Adriano, Patricia Brasil, Rita Maria Ribeiro Nogueira, Carolina Cardoso Dos Santos, Lance Turtle, Patricia Carvalho de Sequeira, David W Brown, Michael J Griffiths, Ana Maria Bispo de Filippis, Tom Solomon
BACKGROUND: During 2015-16 Brazil experienced the largest epidemic of Zika virus ever reported. This arthropod-borne virus (arbovirus) has been linked to Guillain-Barré syndrome (GBS) in adults but other neurological associations are uncertain. Chikungunya virus has caused outbreaks in Brazil since 2014 but associated neurological disease has rarely been reported here. We investigated adults with acute neurological disorders for Zika, chikungunya and dengue, another arbovirus circulating in Brazil...
February 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29357841/study-on-the-persistence-of-zika-virus-zikv-in-body-fluids-of-patients-with-zikv-infection-in-brazil
#11
Guilherme Amaral Calvet, Edna Oliveira Kara, Silvana Pereira Giozza, Camila Helena Aguiar Bôtto-Menezes, Philippe Gaillard, Rafael Freitas de Oliveira Franca, Marcus Vinicius Guimarães de Lacerda, Marcia da Costa Castilho, Patrícia Brasil, Patrícia Carvalho de Sequeira, Maeve Brito de Mello, Ximena Pamela Diaz Bermudez, Kayvon Modjarrad, Robyn Meurant, Sihem Landoulsi, Adele Schwartz Benzaken, Ana Maria Bispo de Filippis, Nathalie Jeanne Nicole Broutet
BACKGROUND: Zika virus (ZIKV) has been identified in several body fluids of infected individuals. In most cases, it remained detected in blood from few days to 1 week after the onset of symptoms, and can persist longer in urine and in semen. ZIKV infection can have dramatic consequences such as microcephaly and Guillain-Barré syndrome. ZIKV sexual transmission has been documented. A better understanding of ZIKV presence and persistence across biologic compartments is needed to devise rational measures to prevent its transmission...
January 22, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29338803/socio-demographic-inequalities-in-the-clinical-characteristics-of-dengue-haemorrhagic-fever-in-the-city-of-rio-de-janeiro-brazil-2007-2008
#12
Sheila Moura Pone, Yara Hahr Marques Hökerberg, Patricia Brasil, Cecília Carmen de Araújo Nicolai, Rogério Ferrari, Raquel de Vasconcellos Carvalhaes de Oliveira
In 2007-2008, the city of Rio de Janeiro underwent an epidemiological change, with increases in the incidence in children and in severe forms of dengue. To describe the clinical profile and spatial distribution of dengue we performed an ecological study based on dengue surveillance data using the Brazilian classification (2005): dengue fever, dengue haemorrhagic fever (DHF) and dengue with complications. χ 2 test was used to describe the clinical and socio-demographic variables (P < 0.05). Spatial distribution of incidence and case-fatality was explored with thematic maps, Moran and Geary indices (P < 0...
February 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29324961/naturalization-reciprocity-and-marks-of-marital-violence-male-defendants-perceptions
#13
Gilvânia Patrícia do Nascimento Paixão, Alvaro Pereira, Nadirlene Pereira Gomes, Anderson Reis de Sousa, Fernanda Matheus Estrela, Ubirajara Ramos Pereira da Silva Filho, Igor Brasil de Araújo
OBJECTIVE: to analyze male criminals' perception about marital violence. METHOD: An exploratory, descriptive, qualitative study undertaken with 23 men who were criminally prosecuted for marital violence. A multimethod data collection was conducted, with individual interview and focal group techniques combined, between May and December 2015. The data collected were initially categorized using the NVIVO® 11 software program, and then organized using the Collective Subject Discourse method...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29315224/the-zika-virus-epidemic-in-brazil-from-discovery-to-future-implications
#14
REVIEW
Rachel Lowe, Christovam Barcellos, Patrícia Brasil, Oswaldo G Cruz, Nildimar Alves Honório, Hannah Kuper, Marilia Sá Carvalho
The first confirmed case of Zika virus infection in the Americas was reported in Northeast Brazil in May 2015, although phylogenetic studies indicate virus introduction as early as 2013. Zika rapidly spread across Brazil and to more than 50 other countries and territories on the American continent. The Aedes aegypti mosquito is thought to be the principal vector responsible for the widespread transmission of the virus. However, sexual transmission has also been reported. The explosively emerging epidemic has had diverse impacts on population health, coinciding with cases of Guillain-Barré Syndrome and an unexpected epidemic of newborns with microcephaly and other neurological impairments...
January 9, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29311638/an-assay-for-the-identification-of-plasmodium-simium-infection-for-diagnosis-of-zoonotic-malaria-in-the-brazilian-atlantic-forest
#15
Denise Anete Madureira de Alvarenga, Richard Culleton, Anielle de Pina-Costa, Danielle Fonseca Rodrigues, Cesare Bianco, Sidnei Silva, Ana Júlia Dutra Nunes, Julio César de Souza, Zelinda Maria Braga Hirano, Sílvia Bahadian Moreira, Alcides Pissinatti, Filipe Vieira Santos de Abreu, André Luiz Lisboa Areas, Ricardo Lourenço-de-Oliveira, Mariano Gustavo Zalis, Maria de Fátima Ferreira-da-Cruz, Patricia Brasil, Cláudio Tadeu Daniel-Ribeiro, Cristiana Ferreira Alves de Brito
Zoonotic malaria poses a unique problem for malaria control. Autochthonous cases of human malaria in the Atlantic Forest have recently been attributed to Plasmodium simium, a parasite that commonly infects non-human primates in this Brazilian biome. However, due to its close similarity at both the morphological and molecular level to Plasmodium vivax, the diagnosis of P. simium in this region remains problematic. Therefore, a diagnostic assay able to accurately identify P. simium is important for malaria surveillance...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29236779/detection-and-molecular-characterization-of-the-novel-recombinant-norovirus-gii-p16-gii-4-sydney-in-southeastern-brazil-in-2016
#16
Débora Maria Pires Gonçalves Barreira, Túlio Machado Fumian, Marco André Loureiro Tonini, Lays Paula Bondi Volpini, Rodrigo Pratte Santos, Anézia Lima Chaves Ribeiro, José Paulo Gagliardi Leite, Márcia Terezinha Baroni de Moraes E Souza, Patrícia Brasil, Denise Cotrim da Cunha, Marize Pereira Miagostovich, Liliana Cruz Spano
Noroviruses are the leading cause of acute gastroenteritis (AGE) in all age groups worldwide. Despite the high genetic diversity of noroviruses, most AGE outbreaks are caused by a single norovirus genotype: GII.4. Since 1995, several different variants of norovirus GII.4 have been associated with pandemics, with each variant circulating for 3 to 8 years. The Sydney_2012 variant was first reported in Australia and then in other countries. A new variant, GII.P16-GII.4, was recently described in Japan and South Korea and then in the USA, France, Germany and England...
2017: PloS One
https://www.readbyqxmd.com/read/29145452/behavioral-climatic-and-environmental-risk-factors-for-zika-and-chikungunya-virus-infections-in-rio-de-janeiro-brazil-2015-16
#17
Trevon L Fuller, Guilherme Calvet, Camila Genaro Estevam, Jussara Rafael Angelo, Gbenga J Abiodun, Umme-Aiman Halai, Bianca De Santis, Patricia Carvalho Sequeira, Eliane Machado Araujo, Simone Alves Sampaio, Marco Cesar Lima de Mendonça, Allison Fabri, Rita Maria Ribeiro, Ryan Harrigan, Thomas B Smith, Claudia Raja Gabaglia, Patrícia Brasil, Ana Maria Bispo de Filippis, Karin Nielsen-Saines
The burden of arboviruses in the Americas is high and may result in long-term sequelae with infants disabled by Zika virus infection (ZIKV) and arthritis caused by infection with Chikungunya virus (CHIKV). We aimed to identify environmental drivers of arbovirus epidemics to predict where the next epidemics will occur and prioritize municipalities for vector control and eventual vaccination. We screened sera and urine samples (n = 10,459) from residents of 48 municipalities in the state of Rio de Janeiro for CHIKV, dengue virus (DENV), and ZIKV by molecular PCR diagnostics...
2017: PloS One
https://www.readbyqxmd.com/read/28991862/isolated-retinal-metastasis-from-breast-cancer
#18
Patricia Correa de Mello, Oswaldo F M Brasil
No abstract text is available yet for this article.
November 2017: Retina
https://www.readbyqxmd.com/read/28715527/screening-criteria-for-ophthalmic-manifestations-of-congenital-zika-virus-infection
#19
Andrea A Zin, Irena Tsui, Julia Rossetto, Zilton Vasconcelos, Kristina Adachi, Stephanie Valderramos, Umme-Aiman Halai, Marcos Vinicius da Silva Pone, Sheila Moura Pone, Joel Carlos Barros Silveira Filho, Mitsue S Aibe, Ana Carolina C da Costa, Olivia A Zin, Rubens Belfort, Patricia Brasil, Karin Nielsen-Saines, Maria Elisabeth Lopes Moreira
Importance: Current guidelines recommend screening eye examinations for infants with microcephaly or laboratory-confirmed Zika virus infection but not for all infants potentially exposed to Zika virus in utero. Objective: To evaluate eye findings in a cohort of infants whose mothers had polymerase chain reaction-confirmed Zika virus infection during pregnancy. Design, Setting, and Participants: In this descriptive case series performed from January 2 through October 30, 2016, infants were examined from birth to 1 year of age by a multidisciplinary medical team, including a pediatric ophthalmologist, from Fernandes Figueira Institute, a Ministry of Health referral center for high-risk pregnancies and infectious diseases in children in Rio de Janeiro, Brazil...
September 1, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28671287/protein-misfolding-diseases-prospects-of-pharmacological-treatment
#20
REVIEW
A Gámez, P Yuste-Checa, S Brasil, Á Briso-Montiano, L R Desviat, M Ugarte, C Pérez-Cerdá, B Pérez
Protein misfolding has been linked to numerous inherited diseases. Loss- and gain-of-function mutations (common features of genetic diseases) may cause the destabilization of proteins, leading to alterations in their properties and/or cellular location, resulting in their incorrect functioning. Misfolded proteins can, however, be rescued via the use of proteostasis regulators and/or pharmacological chaperones, suggesting that treatments with small molecules might be developed for a range of genetic diseases...
March 2018: Clinical Genetics
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