Seyed Hani Hojjati, Gloria C Chiang, Tracy A Butler, Mony de Leon, Ajay Gupta, Yi Li, Mert R Sabuncu, Farnia Feiz, Siddharth Nayak, Jacob Shteingart, Sindy Ozoria, Saman Gholipour Picha, Yaakov Stern, José A Luchsinger, Davangere P Devanand, Qolamreza R Razlighi
BACKGROUND: Histopathologic studies of Alzheimer's disease (AD) suggest that extracellular amyloid-β (Aβ) plaques promote the spread of neurofibrillary tau tangles. However, these two proteinopathies initiate in spatially distinct brain regions, so how they interact during AD progression is unclear. OBJECTIVE: In this study, we utilized Aβ and tau positron emission tomography (PET) scans from 572 older subjects (476 healthy controls (HC), 14 with mild cognitive impairment (MCI), 82 with mild AD), at varying stages of the disease, to investigate to what degree tau is associated with cortical Aβ deposition...
March 29, 2024: Journal of Alzheimer's Disease: JAD