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https://www.readbyqxmd.com/read/28338925/tobacco-use-oral-health-and-risk-of-parkinson-s-disease
#1
Zhiwei Liu, Ann Roosaar, Tony Axéll, Weimin Ye
Few studies have investigated the associations between use of Swedish moist snuff (snus), associated poor oral health, and risk of Parkinson's disease (PD). We followed 20,175 participants who were free of PD in 1973-1974 in Uppsala, Sweden, until the end of 2012. We used Cox proportional hazards regression models to estimate hazard ratios and corresponding 95% confidence intervals for the associations between tobacco use, oral health indicators, and PD risk. We found that tobacco use was associated with a lower risk of PD in males...
March 9, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28335787/risk-factors-of-atherosclerotic-tissue-types-in-single-vessel-and-intermediate-coronary-lesions-a-cross-sectional-study
#2
Xianjin Wang, Qun Chen, Yu Xu, Yanqing Wang, Yang Yang, Ming Gu, Haihua Xu, Yanfang Zhao
BACKGROUND: Few data exist that correlate lesion-related risk factors such as conventional cardiovascular risks or lipoprotein-associated phospholipase A2 (Lp-PLA2) with tissue types within atherosclerotic plaques in patients with single-vessel and intermediate coronary lesions. METHODS: One hundred and ninety-two patients with single-vessel and intermediate coronary lesions were enrolled in a cross-sectional study and divided into two groups: stable angina pectoris (SAP) and acute coronary syndrome (ACS) groups...
March 23, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28330958/intracranial-atherosclerosis-and-dementia-the-atherosclerosis-risk-in-communities-aric-study
#3
Jennifer L Dearborn, Yiyi Zhang, Ye Qiao, Muhammad Fareed K Suri, Li Liu, Rebecca F Gottesman, Andreea M Rawlings, Thomas H Mosley, Alvaro Alonso, David S Knopman, Eliseo Guallar, Bruce A Wasserman
OBJECTIVE: To explore the association of intracranial atherosclerotic disease (ICAD) with mild cognitive impairment (MCI) and dementia. METHODS: From 2011 to 2013, 1,744 participants completed high-resolution vessel wall MRI from the population-based Atherosclerosis Risk in Communities Study by a sampling strategy that allowed weighting back to the cohort. We defined ICAD by plaque features (presence, territory, stenosis, number). Trained clinicians used an algorithm incorporating information from interviews and neuropsychological and neurologic examinations to adjudicate for MCI and dementia...
March 22, 2017: Neurology
https://www.readbyqxmd.com/read/28327165/effect-of-cigarette-smoking-on-subgingival-bacteria-in-healthy-subjects-and-patients-with-chronic-periodontitis
#4
Jumana A Karasneh, Rola A Al Habashneh, Nour Aldain S Marzouka, Martin H Thornhill
BACKGROUND: Cigarette smoking is known to increase the risk of periodontal destruction and developing chronic periodontitis (CP). It is also reported to affect the subgingival bacterial profile among CP patients. However, studies on the effect of smoking on the bacterial profile among healthy subjects are still limited. Therefore, the aim of this study was to investigate the impact of smoking on the subgingival bacterial profile in both healthy adults and CP patients. METHODS: Subgingival plaque samples were collected from CP patients (30 nonsmokers and 9 smokers) and healthy subjects (37 non-smokers and 18 smokers)...
March 21, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28326854/subclinical-carotid-atherosclerosis-in-patients-with-chronic-obstructive-pulmonary-disease-a-meta-analysis-of-literature-studies
#5
Pasquale Ambrosino, Roberta Lupoli, Giovanni Cafaro, Salvatore Iervolino, Mauro Carone, Nicola Pappone, Matteo Nicola Dario Di Minno
BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients have an increased cardiovascular (CV) morbidity and mortality. Common carotid intima-media thickness (CCA-IMT) and carotid plaques are surrogate markers of subclinical atherosclerosis and predictors of CV events. METHODS AND RESULTS: We performed a meta-analysis to evaluate the association between COPD and subclinical atherosclerosis. Studies evaluating the impact of COPD on CCA-IMT and on the prevalence of carotid plaques were systematically searched...
March 22, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28326436/reference-region-selection-and-the-association-between-the-rate-of-amyloid-accumulation-over-time-and-the-baseline-amyloid-burden
#6
Janusch Blautzik, Matthias Brendel, Julia Sauerbeck, Sebastian Kotz, Franziska Scheiwein, Peter Bartenstein, John Seibyl, Axel Rominger
Relative quantitative analysis of amyloid plaque burden in Alzheimer's disease (AD) patients can be reported as standardized uptake value ratio (SUVR) from positron emission tomography (PET). Here, the SUVR is the ratio of the mean amyloid radioligand retention in a composite (COMP) neocortical volume of interest (VOI) to that in a reference VOI, such as the cerebellum, brainstem (BST)/pons, or white matter (WM). Some longitudinal PET investigations show that the rate of amyloid accumulation to follow-up has an inverted U relationship with baseline amyloid SUVR relative to cerebellar or brainstem/pons reference VOIs...
March 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28326297/coronary-artery-calcium-score-and-bone-metabolism-a-pilot-study-in-postmenopausal-women
#7
Pooneh Salari, Abbasali Keshtkar, Shapour Shirani, Leila Mounesan
BACKGROUND: Since 1991 many studies evaluated the link between cardiovascular diseases and osteoporosis, two age-related conditions, but the main common pathologic pathway has not been determined yet. The histological similarity between arterial calcified plaque and bone matrix and involvement of similar cells and mediators provide a special field of research. Therefore in the present study, we aimed to evaluate the relationship between coronary artery calcium score (CACS) as a surrogate marker of atherosclerosis and bone mediators and parameters in postmenopausal women...
February 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28325524/current-status-of-lipid-management-in-acute-coronary-syndrome
#8
REVIEW
Koichiro Fujisue, Kenichi Tsujita
The development of coronary revascularization has dramatically improved early cardiovascular outcomes in patients with acute coronary syndrome (ACS). However, patients who have experienced myocardial infarction (MI) are at high risk of recurrence of cardiovascular events compared with those who are healthy or have stable coronary artery disease. Acute coronary events induce further inflammatory responses and plaque vulnerability in either a coronary culprit or whole vessels. The majority of data have supported the importance of coronary risk management to prevent secondary events...
March 18, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28321471/feasibility-of-in-vivo-18-f-florbetaben-pet-mr-imaging-of-human-carotid-amyloid-%C3%AE
#9
Jan Bucerius, Henryk Barthel, Solveig Tiepolt, Peter Werner, Judith C Sluimer, Joachim E Wildberger, Marianne Patt, Swen Hesse, Hermann-Josef Gertz, Erik A L Biessen, Felix M Mottaghy, Osama Sabri
PURPOSE: Amyloid-beta (Aβ) peptides are involved in the inflammatory pathology of atherosclerosis. (18)F-Florbetaben is a PET tracer for clinical imaging of cerebral Aβ plaques in Alzheimer's disease (AD). We sought to determine whether specific uptake of (18)F-florbetaben in the carotid arteries can be identified using a fully integrated hybrid PET/MRI system and whether this uptake is associated with clinical cardiovascular disease (CVD) risk factors. METHODS: Carotid (18)F-florbetaben uptake was quantified as the mean of the maximum target-to-background ratio (meanTBRmax) in 40 cognitively impaired subjects (age 68...
March 21, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28321238/association-of-non-synonymous-variants-in-wipf3-and-lipa-genes-with-abdominal-aortic-aneurysm-an-autopsy-study
#10
Yuko Maeda, Noriko Sato, Makiko Naka-Mieno, Seijiro Mori, Tomio Arai, Masashi Tanaka, Masaaki Muramatsu, Motoji Sawabe
BACKGROUND: Abdominal aortic aneurysm (AAA) is a multifactorial disease with strong genetic components. Various genetic loci have been associated with clinical AAA, but few studies have investigated pathological AAA, an intermediate phenotype of the disease. METHODS: We examined 2263 consecutive autopsies of older Japanese subjects from a study on geriatric diseases in Japanese individuals (The JG-SNP study). The presence of AAA was determined with a pathological diagnosis during autopsy...
December 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28316002/the-impact-of-periodontal-disease-on-physical-and-psychological-domains-in-long-term-hemodialysis-patients-a-cross-sectional-study
#11
Gabriel Veisa, Alexandra Tasmoc, Ionut Nistor, Liviu Segall, Dimitrie Siriopol, Sorina Mihaela Solomon, Mihaela Dora Donciu, Luminita Voroneanu, Andra Nastasa, Adrian Covic
PURPOSE: Periodontal disease is a chronic infectious disease. Individuals with end-stage kidney disease (ESKD) experience impaired quality of life (QoL) and low oral health. This is the first comprehensive study which aimed to explore the link between periodontal disease and quality of life, assessed with the Short Form 36-Item Health Survey in hemodialysis patients. METHODS: In total, 101 patients (57 females) with ESKD were recruited from two Romanian dialysis centers...
March 18, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28304209/subgingival-microbiota-in-caucasian-patients-with-desquamative-gingivitis-a-cross-sectional-study
#12
Paolo G Arduino, Federica Romano, Danilo Sasia, Roberto Broccoletti, Fulvio Ricceri, Anna Maria Barbui, Silvia Brossa, Raffaella Cipriani, Luca Cricenti, Marco Cabras, Mario Aimetti
BACKGROUND: The presence of epithelial desquamation, erythema, and erosions on the gingival tissue is usually described in literature as desquamative gingivitis (DG). A wide range of autoimmune/dermatological disorders can manifest as DG, although the two more common are oral lichen planus and mucous membrane pemphigoid. The aim of this study was to investigate the prevalence of 11 periodonto-pathogenic microorganisms in DG cases and to compare it with microbiologic status of individuals affected by plaque-induced gingivitis (GI)...
March 17, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28294149/oral-health-in-relation-to-all-cause-mortality-the-ipc-cohort-study
#13
Margaux Adolph, Christelle Darnaud, Frédérique Thomas, Bruno Pannier, Nicolas Danchin, G David Batty, Philippe Bouchard
We evaluated the association between oral health and mortality. The study population comprised 76,188 subjects aged 16-89 years at recruitment. The mean follow-up time was 3.4 ± 2.4 years. Subjects with a personal medical history of cancer or cardiovascular disease and death by casualty were excluded from the analysis. A full-mouth clinical examination was performed in order to assess dental plaque, dental calculus and gingival inflammation. The number of teeth and functional masticatory units <5 were recorded...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28291840/a-wild-type-mouse-based-model-for-the-regression-of-inflammation-in-atherosclerosis
#14
Michael Peled, Hitoo Nishi, Ada Weinstock, Tessa J Barrett, Felix Zhou, Alexandra Quezada, Edward A Fisher
Atherosclerosis can be induced by the injection of a gain-of-function mutant of proprotein convertase subtilisin/kexin type 9 (PCSK9)-encoding adeno-associated viral vector (AAVmPCSK9), avoiding the need for knockout mice models, such as low-density lipoprotein receptor deficient mice. As regression of atherosclerosis is a crucial therapeutic goal, we aimed to establish a regression model based on AAVmPCSK9, which will eliminate the need for germ-line genetic modifications. C57BL6/J mice were injected with AAVmPCSK9 and were fed with Western diet for 16 weeks, followed by reversal of hyperlipidemia by a diet switch to chow and treatment with a microsomal triglyceride transfer protein inhibitor (MTPi)...
2017: PloS One
https://www.readbyqxmd.com/read/28285652/circulating-adiponectin-levels-in-relation-to-carotid-atherosclerotic-plaque-presence-ischemic-stroke-risk-and-mortality-a-systematic-review-and-meta-analyses
#15
Jessica Gorgui, Karina Gasbarrino, Marios K Georgakis, Maria A Karalexi, Bénédicte Nauche, Eleni Th Petridou, Stella S Daskalopoulou
BACKGROUND: Low circulating levels of adiponectin, an anti-inflammatory and vasculoprotective adipokine, are associated with obesity, type 2 diabetes, and atherosclerotic disease. Presence of unstable plaques in the carotid artery is a known etiological factor causing ischemic strokes. Herein, we systematically reviewed the association between circulating adiponectin and progression of carotid atherosclerotic disease, particularly evaluating the occurrence of (1) carotid atherosclerotic plaques, (2) ischemic stroke, and (3) mortality in subjects who suffered a previous ischemic stroke...
April 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28285092/visceral-to-subcutaneous-fat-ratio-is-independently-related-to-small-and-large-cerebrovascular-lesions-even-in-healthy-subjects
#16
Satoshi Higuchi, Yusuke Kabeya, Kiyoe Kato
BACKGROUND AND AIMS: The severity of obesity is evaluated by visceral-to-subcutaneous fat ratio (VS ratio), which may be useful for predicting atherosclerosis. However, it is unclear how VS ratio affects different types of cerebrovascular lesions. This study was conducted to evaluate the clinical impact of visceral fat accumulation on the cerebrovascular lesions. METHODS: This cross-sectional study included 980 apparently healthy Japanese adults who underwent a health check-up program focused toward atherosclerosis, between 2011 and 2014...
March 2, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28282519/nonimpacted-third-molars-affect-the-periodontal-status-of-adjacent-teeth-a%C3%A2-cross-sectional-study
#17
Zhi-Bang Li, Hong-Lei Qu, Li-Na Zhou, Bei-Min Tian, Li-Na Gao, Fa-Ming Chen
PURPOSE: Most previous studies of the effect of third molars (M3s) on the health of adjacent second molars (A-M2s) have focused on impacted M3s (I-M3s). The purpose of this study was to investigate whether nonimpacted M3 (N-M3s) could affect the periodontal status of A-M2s. PATIENTS AND METHODS: In this cross-sectional study, patients (≥18 years) who had at least 1 quadrant with intact first and second molars and a nonimpacted or absent M3 were enrolled in this study...
February 15, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28281951/bedsharing-and-oral-health-related-feeding-behaviors-among-zero-to-three-year-old-children
#18
Vanessa R Axelsen, Arwa I Owais, Fang Qian, Cameron L Perigo, Karin Weber-Gasparoni
PURPOSE: The purpose of this study was to investigate the association between bedsharing and oral health-related feeding behaviors among zero- to three-year-old children. METHODS: Data were collected from records of children attending the University of Iowa's Infant Oral Health Program (1998 to 2009), including maternal demographics, children's nighttime dietary practices, bedsharing habits, methods to help children sleep, and clinical evidence of plaque and caries...
November 15, 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/28281456/insulin-resistance-in-systemic-lupus-erythematosus-patients-contributing-factors-and-relationship-with-subclinical-atherosclerosis
#19
Hiurma Sánchez-Pérez, Beatriz Tejera-Segura, Antonia de Vera-González, Alejandra González-Delgado, José Manuel Olmos, José Luis Hernández, Alfonso Corrales, Raquel López-Mejías, Miguel Angel González-Gay, Iván Ferraz-Amaro
OBJECTIVES: Insulin resistance (IR) plays a role in the increased cardiovascular risk of systemic lupus erythematosus (SLE) patients. This study aimed to determine the potential association of IR with disease activity, drug exposure and subclinical atherosclerosis in patients with SLE. METHODS: This cross-sectional study encompassed 87 non-diabetic SLE patients and 82 sex-matched controls. Insulin and C-peptide serum levels, IR indexes by homeostatic model assessment (HOMA2) (both insulin-based: HOMA2-IR, and with C-peptide: HOMA2-IR-C-peptide) and lipid profiles were assessed in patients and controls...
March 8, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28280308/evaluation-of-psoriasis-patients-attitudes-toward-benefit-risk-and-therapeutic-trade-offs-in-their-choice-of-treatments
#20
Lina Eliasson, Anthony P Bewley, Farhan Mughal, Karissa M Johnston, Andreas Kuznik, Chloe Patel, Andrew J Lloyd
OBJECTIVE: Treatment options for psoriasis offer trade-offs in terms of efficacy, convenience, and risk of adverse events. We evaluated patients' preferences with respect to benefit-risk in the treatment of psoriasis. METHODS: A discrete choice experiment was conducted in adults from the UK with moderate-to-severe psoriasis using an orthogonal design with 32 hypothetical choice sets. Participants were randomly assigned to one of two surveys with 16 choice sets. Patients' preferences were investigated with respect to the following attributes: reduction in body surface area affected by psoriasis, treatment administration (frequency and mode of delivery), short-term diarrhea or nausea risk, and 10-year risk of developing melanoma or nonmelanoma skin cancer, tuberculosis, or serious infections...
2017: Patient Preference and Adherence
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