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https://www.readbyqxmd.com/read/29779262/-salivary-exrna-biomarkers-to-detect-gingivitis-and-monitor-disease-regression
#1
Karolina Elżbieta Kaczor-Urbanowicz, Harsh M Trivedi, Patricia O Lima, Paulo M Camargo, William V Giannobile, Tristan R Grogan, Frederico O Gleber-Netto, Yair Whiteman, Feng Li, Hyo Jung Lee, Karan Dharia, Katri Aro, Carmen Martin Carerras-Presas, Saarah Amuthan, Manjiri Vartak, David Akin, Hiba Al-Adbullah, Kanika Bembey, Perry R Klokkevold, David Elashoff, Virginia Monsul Barnes, Rose Richter, William DeVizio, James G Masters, David Wong
AIM: This study tests the hypothesis that salivary extracellular RNA (exRNA) biomarkers can be developed for gingivitis detection and monitoring disease regression. MATERIALS AND METHODS: Salivary exRNA biomarker candidates were developed from a total of 100 gingivitis and non-gingivitis individuals using Affymetrix's expression microarrays. The top ten differentially expressed exRNAs were tested in a clinical cohort to determine if the discovered salivary exRNA markers for gingivitis were associated with clinical gingivitis and disease regression...
May 19, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29776016/psoriasis-area-and-severity-index-pasi-response-in-moderate-severe-psoriatic-patients-switched-to-adalimumab-results-from-the-oppsa-study
#2
M Talamonti, M Galluzzo, N Bernardini, G Caldarola, S Persechino, F Cantoresi, C G Egan, C Potenza, K Peris, L Bianchi
BACKGROUND: Few studies have compared the efficacy of switching to adalimumab in the real-life setting in plaque psoriasis patients. OBJECTIVE: To evaluate the effect of adalimumab in psoriasis patients previously treated with other biologics. METHODS: In this multicentre study, psoriasis patients (N=262) treated with an anti-TNF alpha agent, ustekinumab or naïve to biologics then switched to adalimumab were included. Disease severity was assessed by the Psoriasis Area and Severity Index (PASI) at baseline and after 3, 6, 12, 24 and 36 months...
May 18, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29772998/partially-purified-aqueous-fraction-of-desmodium-gyrans-dc-improves-reverse-cholesterol-transport-and-lipoprotein-metabolism-in-wistar-rats-fed-with-high-fat-diet
#3
M S Indu, Jose Padikkala, Achuthan C Raghavamenon
Apart from the conventional hypolipidemic therapy, plaque regression through enhanced reverse cholesterol transport (RCT) has emerged as novel approach in atherosclerotic drug development. High-density lipoprotein (HDL) mimetics as well as agents that augment the functional HDL and RCT pathways are under intense exploration. Desmodium gyrans (Fabacea) has been shown to have hypolipidemic efficacy, with an HDL-enhancing property. In this study, a chromatographically purified active fraction of D. gyrans (DGMAF) significantly decreased the serum and lipid profiles as well as lipotoxicity in liver in Wistar rats fed with high-fat diet (HFD)...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29763516/influence-of-plaque-control-on-the-relationship-between-rheumatoid-arthritis-and-periodontal-health-status-among-japanese-rheumatoid-arthritis-patients
#4
Hiroko Hashimoto, Shimpei Hashimoto, Akinori Muto, Nanae Dewake, Yoshihiro Shimazaki
BACKGROUND: Functional disability of the finger joints in rheumatoid arthritis (RA) patients could affect their oral hygiene and periodontal status due to poor plaque control. We examined the influence of plaque control on the relationship between the severity of RA and periodontal status in RA patients. METHODS: This study recruited 89 Japanese RA patients who reported no difficulty in performing oral hygiene. We assessed RA severity using four indices: the Steinbrocker stage and class, the Health Assessment Questionnaire (HAQ) and the Disease Activity Score (DAS)...
May 15, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29759940/a-correlational-study-on-cerebral-microbleeds-and-carotid-atherosclerosis-in-patients-with-ischemic-stroke
#5
Fang-Fang Zhao, Hao-Yuan Gao, Yuan Gao, Zhuan Zhao, Juan Li, Fang-Bo Ning, Xin-Na Zhang, Zhi-Gao Wang, Ai-Ling Yu, Yan-Yong Guo, Bao-Liang Sun
PURPOSE: This study aimed to investigate the correlation between cerebral microbleeds and carotid atherosclerosis in patients with ischemic stroke. SUBJECTS AND METHODS: Patients with ischemic stroke treated in a hospital in China from 2016 to 2017 were enrolled in the study. Based on the results from susceptibility-weighted imaging, the patients were divided into cerebral microbleed and noncerebral microbleed groups. The degree of carotid atherosclerosis was assessed with carotid intima-media thickness (CIMB) and Crouse score of carotid plaque...
May 11, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29757485/tobacco-smoking-decreases-clinical-symptoms-of-gingivitis-in-patients-with-type-1-diabetes-a-cross-sectional-study
#6
Mateusz Tarnowski, Anna Duda-Sobczak, Jakub Lipski, Dorota Zozulinska-Ziolkiewicz, Marzena Wyganowska-Swiatkowska
OBJECTIVE: Periodontal disease may develop on the background of microvascular complications of diabetes. However, some modifying factors, such as tobacco smoking should be taken into consideration when assessing risk of development of chronic complications. The aim of the study was the clinical assessment of the periodontal status in patients with type 1 diabetes according to tobacco smoking. SUBJECTS AND METHODS: 362 subjects aged 29 (IQR 22-35) years, type 1 diabetes duration 12 (8-18) years, hemoglobin A1c, HbA1c 8...
May 14, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29752756/soluble-urokinase-type-plasminogen-activator-receptor-is-associated-with-signs-of-periodontitis-in-adolescents
#7
Peter D Skottrup, Gunnar Dahlén, Vibeke Baelum, Rodrigo Lopez
Owing to its molecular stability in body fluids, soluble urokinase-type plasminogen activator receptor (suPAR) is used as a biomarker for the level of systemic inflammation. This study compares the suPAR levels in serum with those in the saliva of adolescents and evaluates their association with the periodontal conditions. Adolescents identified as screen positive (n = 87) or screen negative (n = 73) for periodontitis had saliva and serum samples taken, along with subgingival plaque samples. The concentrations of suPAR were determined in saliva and serum, and 18 microbial species and the immunoglobulin response to them was evaluated...
May 11, 2018: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29747872/early-ultrasonographic-tumor-regression-after-linear-accelerator-stereotactic-fractionated-photon-radiotherapy-of-choroidal-melanoma-as-a-predictor-for-metastatic-spread
#8
Christoph Mitsch, Martin Zehetmayer, Andreas Gleiss, Dietmar Georg, Karin Dieckmann, Richard Pötter, Ramzi Sayegh, Ursula Schmidt-Erfurth, Roman Dunavoelgyi
BACKGROUND AND PURPOSE: During extended follow-up (of up to 15 years), approximately fifty percent of patients with choroidal melanoma will develop metastatic disease and eventually die. Thus, continuing research on prognostic factors, early detection and treatment is necessary. Height regression rates both after plaque brachytherapy and proton beam irradiation have been shown to have prognostic value. The purpose of this study was to analyze the influence of early tumor regression rate after treatment of choroidal melanoma with LINAC stereotactic fractionated radiotherapy (SFRT) as an independent risk factor for metastasis...
May 8, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29747013/relationship-between-high-sodium-and-low-pufa-intake-and-carotid-atherosclerosis-in-elderly-women
#9
Elisa Mazza, Yvelise Ferro, Theodora Lamprinoudi, Carmine Gazzaruso, Patrizia Doldo, Arturo Pujia, Tiziana Montalcini
Several biologically active molecules including nutrients can affect the vascular endothelium which becomes dysfunctional and, as a consequence, predisposes to atherosclerosis. However, the impact of the intake of sodium and polyunsaturated fatty acids on carotid atherosclerosis in a population of elderly women has scarcely been studied. Our aim was to investigate the association between carotid intima-media thickness and atherosclerotic plaque and nutrient intake in asymptomatic elderly women. Carotid atherosclerosis was determined by duplex ultrasound in 108 elderly women...
May 7, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29743417/impact-of-indoxyl-sulfate-on-coronary-plaques-in-patients-on-hemodialysis
#10
Masahiko Asami, Kengo Tanabe, Shunsuke Ito, Eri Yoshida, Jiro Aoki, Shuzou Tanimoto, Yu Horiuchi, Masayuki Yoshida
Serum indoxyl sulfate (IS; a uremic toxin) levels, which are significantly higher in patients with chronic kidney disease, including those undergoing hemodialysis, than in the robust, are associated with both cardiovascular disease (CVD) and CVD-related mortality. Furthermore, coronary artery calcium (CAC) is an independent predictor of cardiovascular events in patients undergoing hemodialysis. This study aimed to interpret the association between serum IS levels and coronary plaque burden (CPB) or CAC.A total of 30 consecutive patients on hemodialysis, who underwent 320-row coronary multidetector computed tomography (MDCT) angiography for suspected coronary artery disease, were enrolled in this prospective study...
May 9, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29740720/predictors-of-dental-plaque-and-gingivitis-in-patients-receiving-integrated-dental-treatment-a-longitudinal-retrospective-study
#11
Bárbara Rocha Christofoli, Natália Caldeira Silva, João Augusto Peixoto Oliveira, Marilene Issa Fernandes, Alex Nogueira Haas
OBJECTIVES: The identification of predictors of supragingival biofilm accumulation may improve the results of therapeutic strategies for dental caries and periodontal diseases in general clinical practice. This study aimed to determine predictors of changes in visible plaque (VP) and gingival bleeding (GB) during integrated dental care. MATERIALS AND METHODS: A retrospective longitudinal study was conducted by a census of patients receiving integrated dental care in a general clinical practice ambulatory at the Federal University of Rio Grande do Sul (Brazil)...
May 9, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29738341/effect-of-pitavastatin-and-atorvastatin-on-regression-of-atherosclerosis-assessed-using-intravascular-ultrasound-a-meta-analysis
#12
Hui Liu, Mingjun Zhang, Delong Li, Jingjing Tian, Xuyang Wang, Jinyu Pan, Dian Liu, Xiaowei Li, Fengshuang An
BACKGROUND: The aim of this study is to compare the efficacy and safety of pitavastatin and atorvastatin using data from randomized-controlled trial pooled together by means of a meta-analysis and decide which is better. METHODS: PubMed, CENTRAL, Web of Knowledge, and ClinicalTrials.gov website were searched for randomized-controlled trials published until October 2016. Eligible studies comparing pitavastatin with atorvastatin head to head and reporting the outcome of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), glycated hemoglobin, and intravascular ultrasound evaluation were enrolled...
May 5, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29729869/plasma-trimethylamine-n-oxide-is-associated-with-vulnerable-plaque-characteristics-in-cad-patients-as-assessed-by-optical-coherence-tomography
#13
Xinxin Liu, Zulong Xie, Meng Sun, Xuedong Wang, Ji Li, Jinjin Cui, Fengyun Zhang, Li Yin, Dan Huang, Jingbo Hou, Jinwei Tian, Bo Yu
BACKGROUND: Plaque vulnerability indicates the risk of a cardiovascular event. In the present study, we sought to analyze the relationship between trimethylamine N-oxide (TMAO), a gut microbiota metabolite from dietary phosphatidylcholine, and vulnerable plaque characteristics in patients with coronary artery disease (CAD). METHODS: One hundred eighty non-culprit plaques from 90 patients with ACS or with stable angina were assessed by optical coherence tomography (OCT)...
April 28, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29728081/lead-exposure-may-affect-gingival-health-in-children
#14
Borany Tort, Youn-Hee Choi, Eun-Kyong Kim, Yun-Sook Jung, Mina Ha, Keun-Bae Song, Young-Eun Lee
BACKGROUND: Several studies have reported the harmful effects of lead poisoning. However, the relationship between lead exposure and oral health of children has not been well defined. The aim of this study was to investigate the relationship between blood lead level (BLL) and oral health status of children. METHODS: A total of 351 children (aged 7-15 years) were recruited from the pilot data of the Korean Environmental Health Survey in Children and Adolescents, which was designed to examine environmental exposure and children's health status in South Korea...
May 4, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29724293/plasma-preptin-levels-are-decreased-in-patients-with-essential-hypertension
#15
Huaiqiu Cai, Qingan Liu, Xiaoqiu Dong, Yawen Cai, Jinlai Yao, Yue Liu
The pancreatic hormone preptin amplifies glucose-mediated insulin secretion, and we investigated its circulating levels in patients with essential hypertension and possible association with carotid atherosclerosis. Ninety-eight patients were divided into hypertensive and control groups. Relationships between plasma preptin levels, clinical parameters, and carotid artery intima-media thickness (IMT) were analyzed. Plasma preptin levels were significantly lower in the hypertensive group than in the control group (1930...
May 1, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29716178/solitary-mastocytoma-presenting-at-birth
#16
Non Hyeon Ha, Yoo Jung Lee, Myong Chul Park, Il Jae Lee, Sue Min Kim, Dong Ha Park
Mastocytosis is a rare disease which occurs in both children and adults, and it can manifest as a solitary or multiple skin lesions. Both can cause cutaneous or systemic symptoms. Because of the heterogeneity of clinical presentation of mastocytosis and its rare prevalence, it can be hard to suspect the mastocytosis at the first time. Most solitary mastocytomas are about 1-5 cm in diameter and have features of brownish-yellow, minimally elevated plaques with a smooth shiny surface. This article presents a case of solitary mastocytoma which occurred in neonate and that we treated through surgical excision...
April 28, 2018: Archives of Craniofacial Surgery
https://www.readbyqxmd.com/read/29713306/association-between-carotid-artery-function-and-structure-in-the-northern-manhattan-study
#17
David Della-Morte, Hannah Gardener, Chuanhui Dong, Matthew Markert, Digna Cabral, Mitchell S V Elkind, Ralph L Sacco, Tatjana Rundek
Background and purpose: Carotid plaque (CP), carotid intima media thickness (cIMT), and stiffness (STIFF) are pre-clinical markers of atherosclerosis and predictors of cerebrovascular disease (CVD). We sought to investigate whether STIFF is a significant determinant of cIMT and CP, which may provide an insight into the mechanism by which STIFF adds to the risk of CVD. Methods: We analyzed 876 stroke-free subjects from the Northern Manhattan Study with available ultrasound measures...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29704428/sleep-disturbance-in-psoriasis-a-case-controlled-study
#18
P Jensen, C Zachariae, L Skov, R Zachariae
BACKGROUND: Sleep is essential for daytime functioning and health. Given the physical symptoms of psoriasis, a higher prevalence of sleep disorders could be expected. So far, the studies examining sleep disturbance in psoriasis have been of less-than-optimal methodological quality and with mixed results. OBJECTIVES: We aimed to: 1) examine the prevalence of sleep disturbance in patients with plaque psoriasis compared to controls, 2) evaluate associations with health-related quality of life (HRQoL), and 3) examine possible disease-related predictors of disturbed sleep...
April 28, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29703054/impact-of-von-willebrand-factor-on-coronary-plaque-burden-in-coronary-artery-disease-patients-treated-with-statins
#19
Yuta Kato, Atsushi Iwata, Makito Futami, Motoki Yamashita, Satoshi Imaizumi, Takashi Kuwano, Amane Ike, Makoto Sugihara, Hiroaki Nishikawa, Bo Zhang, Shin'ichiro Yasunaga, Keijiro Saku, Shin-Ichiro Miura
High von Willebrand factor (VWF) levels have been reported to be associated with an increased risk of cardiovascular events. However, the relationship between VWF levels and coronary atherosclerosis in patients with coronary artery disease (CAD) who have already received stain treatment is still unclear. We examined the association between VWF levels and coronary plaque as assessed by intravascular ultrasound (IVUS) in CAD patients treated with statins. Ninety-one CAD patients who underwent percutaneous coronary intervention under IVUS guidance, and who were already receiving statin treatment based on Japanese guidelines, were included...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29702430/metabolic-products-of-the-intestinal-microbiome-and-extremes-of-atherosclerosis
#20
Chrysi Bogiatzi, Gregory Gloor, Emma Allen-Vercoe, Gregor Reid, Ruth G Wong, Bradley L Urquhart, Vincent Dinculescu, Kelsey N Ruetz, Thomas J Velenosi, Michael Pignanelli, J David Spence
BACKGROUND AND AIMS: There is increasing awareness that the intestinal microbiome plays an important role in human health. We investigated its role in the burden of carotid atherosclerosis, measured by ultrasound as total plaque area. METHODS: Multiple regression with traditional risk factors was used to identify three phenotypes among 316/3056 patients attending vascular prevention clinics. Residual score (RES; i.e. the distance off the regression line, similar to standard deviation) was used to identify the 5% of patients with much less plaque than predicted by their risk factors (Protected, RES <-2), the 90% with about as much plaque as predicted (Explained, RES -2 to 2), and the 5% with much more plaque than predicted (Unexplained RES >2)...
April 17, 2018: Atherosclerosis
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