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Plaque regression

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https://www.readbyqxmd.com/read/28729408/femoral-artery-atherosclerosis-is-associated-with-physical-function-across-the-spectrum-of-the-ankle-brachial-index-the-san-diego-population-study
#1
Christina L Wassel, Alicia M Ellis, Natalie C Suder, Emma Barinas-Mitchell, Dena E Rifkin, Nketi I Forbang, Julie O Denenberg, Antoinette M Marasco, Belinda J McQuaide, Nancy S Jenny, Matthew A Allison, Joachim H Ix, Michael H Criqui
BACKGROUND: The ankle-brachial index (ABI) is inadequate to detect early-stage atherosclerotic disease, when interventions to prevent functional decline may be the most effective. We determined associations of femoral artery atherosclerosis with physical functioning, across the spectrum of the ABI, and within the normal ABI range. METHODS AND RESULTS: In 2007-2011, 1103 multiethnic men and women participated in the San Diego Population Study, and completed all components of the summary performance score...
July 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28721838/increased-serum-ferritin-levels-are-independently-associated-with-carotid-atherosclerosis-in-women
#2
Haiyan Xu, Yanqi Song, Jing Xu, Yeqing Gu, Qing Zhang, Li Liu, Ge Meng, Hongmei Wu, Yang Xia, Xue Bao, Hongbin Shi, Qian Su, Liyun Fang, Fei Yu, Huijun Yang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Guolin Wang, Kun Song, Yuntang Wu, Zhong Sun, Kaijun Niu
Previous studies have supported the theory that there is a positive association between ferritin and carotid atherosclerosis in Western people. Diet plays an important role in determining serum ferritin concentration. Asian dietary patterns are different from Western dietary patterns, implying that there may be a difference in the association of ferritin with carotid atherosclerosis between Asian and Western people. However, few studies focus on the association between ferritin and carotid atherosclerosis among Asians...
June 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28719257/no-serologic-evidence-of-middle-east-respiratory-syndrome-coronavirus-infection-among-camel-farmers-exposed-to-highly-seropositive-camel-herds-a-household-linked-study-kenya-2013
#3
Peninah Munyua, Victor Max Corman, Austine Bitek, Eric Osoro, Benjamin Meyer, Marcel A Müller, Erik Lattwein, S M Thumbi, Rees Murithi, Marc-Alain Widdowson, Christian Drosten, M Kariuki Njenga
AbstractHigh seroprevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) among camels has been reported in Kenya and other countries in Africa. To date, the only report of MERS-CoV seropositivity among humans in Kenya is of two livestock keepers with no known contact with camels. We assessed whether persons exposed to seropositive camels at household level had serological evidence of infection. In 2013, 760 human and 879 camel sera were collected from 275 and 85 households respectively in Marsabit County...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28717427/comparison-of-the-effects-of-low-dose-interferon-and-high-dose-interferon-on-reduction-of-the-number-and-size-of-plaques-in-patients-with-multiple-sclerosis-a-historical-cohort
#4
Payam Khomand, Ghobad Moradi, Behrooz Ahsan, Setareh Abtahi
Background: This study was performed to compare the effects of low dose interferon beta-1 (IFN-β-1) (CinnoVex, 30 mcg) and high dose IFN-β-1 (REBIF, 44 mcg) on the reduction of the number and size of plaques in magnetic resonance imaging (MRI) in patients with multiple sclerosis (MS). Methods: This historical cohort study, which was performed in 2014 in Sanandaj (western part of Iran). 43 MS patients in two groups were investigated. The first group, which included 19 patients, was treated using high dose IFN (44 mcg) and the second group, which was consisted of 24 patients, was treated using low dose IFN (30 mcg)...
January 5, 2017: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/28714271/influence-of-residual-renal-function-in-carotid-modeling-as-a-marker-of-early-atherosclerosis-in-dialysis-patients
#5
Merita Rroji, Nereida Spahia, Saimir Seferi, Myftar Barbullushi, Goce Spasovski
Atherosclerosis is frequently present in patients with chronic kidney disease (CKD) treated with dialysis. We evaluated the association between residual renal function (RRF), phosphate level, inflammation and other risk factors in carotid modeling as a marker of early atherosclerosis in peritoneal dialysis (PD) compared with hemodialysis (HD) patients. We studied 39 stable PD and 53 HD patients on renal replacement therapy (RRT) for 3 to 36 months duration. B-mode ultrasonography was used to determine carotid artery intima media thickness (CIMT)...
July 17, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28711401/performance-of-acoustic-radiation-force-impulse-ultrasound-imaging-for-carotid-plaque-characterization-with-histologic-validation
#6
Tomasz J Czernuszewicz, Jonathon W Homeister, Melissa C Caughey, Yue Wang, Hongtu Zhu, Benjamin Y Huang, Ellie R Lee, Carlos A Zamora, Mark A Farber, Joseph J Fulton, Peter F Ford, William A Marston, Raghuveer Vallabhaneni, Timothy C Nichols, Caterina M Gallippi
OBJECTIVE: Stroke is commonly caused by thromboembolic events originating from ruptured carotid plaque with vulnerable composition. This study assessed the performance of acoustic radiation force impulse (ARFI) imaging, a noninvasive ultrasound elasticity imaging method, for delineating the composition of human carotid plaque in vivo with histologic validation. METHODS: Carotid ARFI images were captured before surgery in 25 patients undergoing clinically indicated carotid endarterectomy...
July 13, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28707599/designing-of-selective-%C3%AE-secretase-inhibitory-benzenesulfonamides-through-comparative-in-vitro-and-in-silico-analysis
#7
Neeraj Masand, Satya P Gupta, Ratan Lal Khosa
BACKGROUND: In Alzheimer's disease (AD), the gene mutations have been identified in the amyloid precursor protein (APP), the presenilin-1 (PS1) and -2 (PS2) genes. APP is a transmembrane protein which gets cleaved by α- and β-secretase enzymes and releases Aβ peptides which forms senile plaques in brain tissue. It contributes for local inflammatory response, subsequent oxidative stress, biochemical changes and neuronal death. Targeting the development of Aβ aggregates in the senile plaques is an important strategy in the treatment of AD...
July 13, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28706117/age-specific-sex-differences-in-magnetic-resonance-imaging-depicted-carotid-intraplaque-hemorrhage
#8
Navneet Singh, Alan R Moody, Bowen Zhang, Isabella Kaminski, Kush Kapur, Stephanie Chiu, Pascal N Tyrrell
BACKGROUND AND PURPOSE: Stroke rates are higher in men compared with women in the fourth through seventh decades of life, and higher rates may result from differences in carotid intraplaque hemorrhage (IPH), an unstable atherosclerotic plaque component. We report age-specific sex differences in the presence of magnetic resonance imaging-depicted carotid IPH. METHODS: Patients (n=1115) underwent magnetic resonance imaging for carotid IPH between 2005 and 2014. Low-grade carotid stenosis patients (n=906) without prior endarterectomy were eligible for this cross-sectional study...
July 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28705310/subclinical-atherosclerosis-burden-by-3d%C3%A2-ultrasound-in-mid-life-the-pesa-study
#9
Beatriz López-Melgar, Leticia Fernández-Friera, Belén Oliva, José Manuel García-Ruiz, José Luis Peñalvo, Sandra Gómez-Talavera, Javier Sánchez-González, José María Mendiguren, Borja Ibáñez, Antonio Fernández-Ortiz, Javier Sanz, Valentín Fuster
BACKGROUND: Detection of subclinical atherosclerosis improves risk prediction beyond cardiovascular risk factors (CVRFs) and risk scores, but quantification of plaque burden may improve it further. Novel 3-dimensional vascular ultrasound (3DVUS) provides accurate volumetric quantification of plaque burden. OBJECTIVES: The authors evaluated associations between 3DVUS-based plaque burden and CVRFs and explored potential added value over simple plaque detection. METHODS: The authors included 3,860 (92...
July 18, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28704403/genetic-variants-of-ptgs2-txa2r-and-txas1-are-associated-with-carotid-plaque-vulnerability-platelet-activation-and-txa2-levels-in-ischemic-stroke-patients
#10
Xingyang Yi, Jing Lin, Hua Luo, Chun Wang, Yingying Liu
Eicosanoids may play a role in ischemic stroke. However, the associations of variants in cyclooxygenase (COX) pathway genes and interaction among these variants with carotid plaque vulnerability are not fully understood. In present study, twelve variants in COX pathway genes were examined using matrix-assisted laser desorption ionization time-of-flight mass spectrometry method in 396 patients with ischemic stroke and 291 controls. Platelet aggregation, platelet-leukocyte aggregates, and urine 11-dehydrothromboxane B2 (11-dTxB2) were also measured...
2017: PloS One
https://www.readbyqxmd.com/read/28704130/scleral-thinning-documented-by-ultrasound-biomicroscopy-after-plaque-therapy-for-anterior-ciliary-melanoma
#11
B Kuzmanović Elabjer, M Bušić, D Miletić, M Bjeloš, N Vukojević, D Bosnar
PURPOSE: To evaluate, by ultrasound biomicroscopy (UBM), changes in scleral thickness after ruthenium-106 CCB and CCC plaque (Eckert & Ziegler BE-BIG GmbH, Berlin, Germany) therapy for anterior ciliary melanoma. METHODS: Eleven patients with anterior ciliary melanoma underwent ruthenium-106 CCB and CCC plaque radiation with a radiation dose at the tumor apex of 80-100 Gy. UBM measurements performed prior to and after treatment were as follows: the largest prominence of the tumor perpendicular to the sclera and scleral thickness at scleral spur, 1...
July 13, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28700834/petroleum-ether-extract-of-njavara-rice-bran-upregulates-jak2-stat3-mediated-anti-inflammatory-profile-in-macrophages-and-aortic-endothelial-cells-promoting-regression-of-atherosclerosis
#12
Chithra K Pushpan, Jayalekshmy Ananthasankaran, Helen Antony
"Njavara"(Oryza sativa Linn) is a unique rice variety grown in Kerala that is reported to have significantly higher antioxidant, anti-inflammatory, chemical indices, and bioactive components compared with staple rice varieties. However, the role of NBE in reversing the atherosclerosis development remains unclear. The present study aimed to elucidate the role of Njavara rice bran petroleum ether extract (NBE) in promoting atherosclerotic regression. Male New Zealand white breed rabbits were divided into three groups...
July 12, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28699976/discordant-lipid-pattern-and-carotid-atherosclerotic-plaque-importance-of-remnant-cholesterol
#13
Walter Masson, Martín Lobo, Graciela Molinero, Daniel Siniawski
Background: Subjects with levels of non-HDL-C 30 mg/dL above those of LDL-C (lipid discordance) or with high remnant cholesterol levels could have a greater residual cardiovascular risk. Objectives: To determine the prevalence of lipid discordance in a primary prevention population and analyze the clinical variables associated with it; To investigate the association between lipid discordance and remnant cholesterol with the presence of carotid plaque. Methods: Primary prevention patients without diabetes or lipid-lowering therapy were included...
June 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28695757/association-between-snoring-and-high-risk-carotid-plaque-features
#14
Erin M Kirkham, Thomas S Hatsukami, Susan R Heckbert, Jie Sun, Gador Canton, Chun Yuan, Edward M Weaver
Objectives Previous studies have demonstrated an association between snoring and carotid disease independent of sleep apnea. The aim of this study was to quantify the association between self-reported snoring and high-risk carotid plaque features on magnetic resonance imaging (MRI) that predict stroke. Study Design Cross-sectional. Setting Tertiary care university hospital and affiliated county hospital. Methods We surveyed 133 subjects with asymptomatic carotid artery disease that had been previously evaluated with high-resolution MRI...
July 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28691207/hyperuricemia-is-an-independent-risk-factor-for-psoriatic-arthritis-in-psoriatic-patients
#15
Noriko Tsuruta, Shinichi Imafuku, Yutaka Narisawa
Psoriatic arthritis (PsA) is a spondyloarthritic condition mainly seen in patients with psoriasis. Psoriatic patients with plaques on the scalp, gluteal fold or nail lesions are known to develop PsA more frequently, but other markers for PsA have not yet been identified. To determine which psoriatic patients are at greatest risk of developing PsA, psoriasis vulgaris (PsV) patients who visited the Department of Dermatology, Fukuoka University Hospital in 2015 were enrolled. Patients with and without PsA were statistically compared with respect to age, sex, age at onset, body mass index (BMI), smoking and drinking habits, familial history of psoriasis and comorbidities...
July 10, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28690216/-plasma-level-of-apelin-and-carotid-atherosclerosis-in-maintenance-hemodialysis-patients
#16
Rong Tang, Ruiling Wang, Xiang Ao, Xiaomiao Cheng
To determine the plasma level of apelin in patients of maintenance hemodialysis (MHD) and to explore the relationship between apelin level and carotid atherosclerosis (AS) in MHD patients.
 Methods: A total of 92 MHD patients and 36 sex- and age-matched healthy subjects were enrolled in this study. The plasma level of apelin was evaluated by radiation immunoassay; serum endothelial injury markers including thrombomodulin, von Willebrand factor (vWF), and CD146, and inflammatory factors including high sensitive C-reactive protein (hsCRP), IL-6 and TNF-α were determined by ELISA...
June 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28687339/inflammation-and-myointimal-hyperplasia-correlation-with-hemodynamic-forces
#17
Antonio V Sterpetti, Alessandra Cucina, Valeria Borrelli, Marco Ventura
OBJECTIVES: The aim of our study was to correlate flow dynamics and the release of inflammatory cytokines Interleukin 1, 2, 6, TNF (Tumour Necrosis Factor) alfa, both in vitro and in vivo. MATERIALS AND METHODS: Endothelial cells were exposed to laminar flow (6dyne/cm(2)) in an in vitro circulatory system and the release of Interleukin 1, 2, 6 and TNF alfa was quantified by ELISA. Interleukin 1, 2, 6 and TNF alfa release was also assessed in vein grafts implanted in the arterial circulation of Lewis rats...
July 5, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28686808/integrating-a-nurse-midwife-led-oral-health-intervention-into-centeringpregnancy-prenatal-care-results-of-a-pilot-study
#18
Sally H Adams, Steven E Gregorich, Sharon S Rising, Margaret Hutchison, Lisa H Chung
INTRODUCTION: National and professional organizations recommend oral health promotion in prenatal care to improve women's oral health. However, few prenatal programs include education about oral health promotion. The objective of this study was to determine if women receiving a brief, low-cost, and sustainable educational intervention entitled CenteringPregnancy Oral Health Promotion had clinically improved oral health compared to women receiving standard CenteringPregnancy care. METHODS: Women attending CenteringPregnancy, a group prenatal care model, at 4 health centers in the San Francisco Bay Area, participated in this nonrandomized controlled pilot study in 2010 to 2011...
July 7, 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/28686117/predicting-ischemic-stroke-after-carotid-artery-stenting-based-on-proximal-calcification-and-the-jellyfish-sign
#19
Nobuhiko Ichinose, Seiji Hama, Toshio Tsuji, Zu Soh, Hideaki Hayashi, Yoshihiro Kiura, Shigeyuki Sakamoto, Takahito Okazaki, Daizo Ishii, Katsuhiro Shinagawa, Kaoru Kurisu
OBJECTIVE Carotid artery stenting (CAS) has been considered to prevent ischemic strokes caused by stenosis of the cervical carotid artery. The most common complication of CAS is new cerebral infarction. The authors have previously reported that the jellyfish sign-the rise and fall of the mobile component of the carotid plaque surface detected by carotid ultrasonography-suggests thinning and rupture of the fibrous cap over the unstable plaque content, such as the lipid-rich necrotic core or internal plaque hemorrhage...
July 7, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28684187/subclinical-vascular-disease-and-the-risk-of-parkinsonism-the-rotterdam-study
#20
Vanja Vlasov, Sirwan K L Darweesh, Bruno H Stricker, Oscar H Franco, M Kamran Ikram, Maryam Kavousi, Daniel Bos, Caroline C W Klaver, M Arfan Ikram
BACKGROUND: Parkinsonism is a common neurodegenerative syndrome in middle-aged and elderly persons. The etiology is multifactorial with a possible vascular contribution, but this has not been comprehensively studied. OBJECTIVE: To determine whether selected markers of subclinical vascular pathology are associated with the risk of all-cause parkinsonism in the general population. METHODS: We assessed a range of markers of subclinical vascular pathology (ankle-brachial index, carotid plaques and intima media thickness, retinal arteriolar and venular calibers) in 6199 persons from the population-based Rotterdam Study, who were free of parkinsonism and dementia at baseline...
June 28, 2017: Parkinsonism & related Disorders
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