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https://www.readbyqxmd.com/read/27895813/cow-s-milk-allergy-towards-an-update-of-dracma-guidelines
#1
REVIEW
Alessandro Fiocchi, Lamia Dahda, Christophe Dupont, Cristina Campoy, Vincenzo Fierro, Antonio Nieto
BACKGROUND: In 2010, the diagnosis and treatment of IgE-mediated CMA were systematized in a GRADE guideline. OBJECTIVES & METHODS: After 6 years, the state of the knowledge in diagnosis and treatment of CMA has largely evolved. We summarize here the main advances, and exemplify indicating some specific points: studies aimed at better knowledge of the effects of breastfeeding and the production of new special formulae intended for the treatment of CMA. The literature (PubMed/MEDLINE) was searched using the following algorithms: (1) [milk allergy] AND diagnosis; (2) [milk allergy] AND [formul*] OR [breast*], setting the search engine [6-years] time and [human] limits...
2016: World Allergy Organization Journal
https://www.readbyqxmd.com/read/27876251/-food-protein-induced-enterocolitis-syndrome-a-case-report-of-diarrhea-with-hypovolemic-shock-and-methemoglobinemia
#2
L Genere, N Pecciarini, N Peretti, F Villard, A Lachaux
We report on the case of a young infant with chronic diarrhea that worsened and turned into hypovolemic shock with methemoglobinemia. We underline and discuss the main features of food protein-induced enterocolitis syndrome (FPIES). FPIES is a non-IgE-mediated food allergy involving tumor necrosis factor-alpha (TNF-α). Many triggering foods exist but cow's milk, as in the case reported herein, is one of the most frequent. It can start early or be delayed and start around the average age of 5 months. Symptoms are nonspecific with diarrhea and vomiting, but in the presence of methemoglobinemia, the diagnosis must be seriously considered...
November 18, 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27845237/early-life-farm-exposures-and-adult-asthma-and-atopy-in-the-agricultural-lung-health-study
#3
John S House, Annah B Wyss, Jane A Hoppin, Marie Richards, Stuart Long, David M Umbach, Paul Henneberger, Laura E Beane Freeman, Dale P Sandler, Elizabeth Long O'Connell, Christie Barker Cummings, Stephanie J London
BACKGROUND: Previous studies, mostly from Europe, suggest that early-life farming exposures protect against childhood asthma and allergy; few data exist on asthma and allergy in adults. OBJECTIVE: To examine associations between early-life farming exposures and current asthma and atopy in an older adult US farming population. METHODS: We analyzed data from 1,746 farmers and 1,555 spouses (mean age=63) from a case-control study nested within the Agricultural Health Study...
November 11, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27799957/prospective-evaluation-of-testing-with-baked-milk-to-predict-safe-ingestion-of-baked-milk-in-unheated-milk-allergic-children
#4
Allison Kwan, Maria Asper, Sasson Lavi, Elana Lavine, David Hummel, Julia E Upton
BACKGROUND: Cow's milk allergy is one of the most common food allergies affecting young children. A subset of milk-allergic individuals can eat baked milk without allergic symptoms which is beneficial in terms of prognostication and liberalization of the diet. A retrospective study suggested that skin prick testing (SPT) with a baked milk (muffin) slurry may provide a sensitive means of predicting the outcome of a medically supervised baked milk oral food challenge. We evaluated the predictive value of SPT with baked milk to identify unheated milk-allergic children who are able to safely eat baked milk...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27799804/relative-cost-effectiveness-of-using-an-extensively-hydrolyzed-casein-formula-in-managing-infants-with-cow-s-milk-allergy-in-brazil
#5
Julian F Guest, Ariana C Yang, Jane Oba, Maraci Rodrigues, Rosane Caetano, Lilian Polster
OBJECTIVE: To estimate the cost-effectiveness of three alternative dietetic strategies for cow's milk allergy in Brazil: 1) using an extensively hydrolyzed casein formula (eHCF; Nutramigen) as a first-line formula, but switching to an amino acid formula (AAF) if infants remain symptomatic; 2) using an AAF as a first-line formula and then switching to an eHCF after 4 weeks once infants are symptom-free, but switching back to an AAF if infants become symptomatic; and 3) using an AAF as a first-line formula and keeping all infants on that formula...
2016: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/27624222/eosinophilia-in-infants-with-food-protein-induced-enterocolitis-syndrome-in-japan
#6
Mitsuaki Kimura, Masaki Shimomura, Hideaki Morishita, Takaaki Meguro, Shiro Seto
BACKGROUND: Many Japanese infants with food protein-induced enterocolitis syndrome (FPIES) show eosinophilia, which has been thought to be a characteristic of food protein-induced proctocolitis (FPIP). METHODS: To elucidate the characteristics of eosinophilia in Japanese FPIES patients, 113 infants with non-IgE-mediated gastrointestinal food allergy due to cow's milk were enrolled and classified into FPIES (n = 94) and FPIP (n = 19). RESULTS: The percentage of peripheral blood eosinophils (Eo) was increased in most FPIES patients (median, 7...
September 10, 2016: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/27622938/breastfeeding-and-il-10-levels-in-children-affected-by-cow-s-milk-protein-allergy-a-restrospective-study
#7
Sara Manti, Vassilios Lougaris, Caterina Cuppari, Lucia Tardino, Valeria Dipasquale, Teresa Arrigo, Carmelo Salpietro, Salvatore Leonardi
AIM: To assess the protective role of breast-feeding in infants with CMPA-related AEDS as well as IL-10 utility as marker of disease evolution. METHODS: 64 breast-feeding children with CMPA-related AEDS (31 males and 33 females; mean age 5.56±2.41months; 21 mild AEDS; 25 moderate AEDS; 18 severe AEDS) and 60 artificial feeding babies (33 males and 27 females; mean age 6.01±2.08months; 26 mild AEDS; 19 moderate AEDS; 15 severe AEDS) were evaluated. In all patients serum IL-10 levels were detected...
September 8, 2016: Immunobiology
https://www.readbyqxmd.com/read/27582492/cow-s-milk-protein-allergy
#8
Grace Mousan, Deepak Kamat
Cow's milk protein allergy (CMPA) is a common condition encountered in children with incidence estimated as 2% to 7.5% in the first year of life. Formula and breast-fed babies can present with symptoms of CMPA. It is important to accurately diagnose CMPA to avoid the consequences of either under- or overdiagnosis. CMPA is classically categorized into immunoglobulin E (IgE)- or non-IgE-mediated reaction that vary in clinical manifestations, diagnostic evaluation, and prognosis. The most commonly involved systems in patients with CMPA are gastrointestinal, skin, and respiratory...
October 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27545065/humoral-and-cellular-responses-to-casein-in-patients-with-food-protein-induced-enterocolitis-to-cow-s-milk
#9
Jean Christoph Caubet, Ramon Bencharitiwong, Andrew Ross, Hugh A Sampson, M Cecilia Berin, Anna Nowak-Węgrzyn
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy manifesting within 1 to 4 hours of food ingestion with repetitive emesis and lethargy. OBJECTIVE: We sought to characterize immune responses to casein in children with FPIES caused by cow's milk (CM). METHODS: Total IgE and IgM, CM-specific IgG, and casein-specific IgE, IgG, IgG4, and IgM levels, as well as immunoglobulin free light chains, were measured in both patients with active and those with resolved CM-FPIES...
July 15, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27498217/awareness-of-allergic-enterocolitis-among-primary-care-paediatricians-a-web-based-pilot-survey
#10
P Comberiati, M Landi, A Martelli, G L Piacentini, C Capristo, G Paiola, D G Peroni
BACKGROUND: Allergic enterocolitis, also known as food protein-induced enterocolitis syndrome (FPIES), is an increasingly reported and potentially severe non-IgE mediated food allergy of the first years of life, which is often misdiagnosed due to its non-specific presenting symptoms and lack of diagnostic guidelines. OBJECTIVE: We sought to determine the knowledge of clinical, diagnostic and therapeutic features of FPIES among Italian primary-care paediatricians...
September 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27455132/infant-milk-formulas-differ-regarding-their-allergenic-activity-and-induction-of-t-cell-and-cytokine-responses
#11
H Hochwallner, U Schulmeister, I Swoboda, M Focke-Tejkl, R Reininger, V Civaj, R Campana, J Thalhamer, S Scheiblhofer, N Balic, F Horak, M Ollert, N G Papadopoulos, S Quirce, Z Szepfalusi, U Herz, E A F van Tol, S Spitzauer, R Valenta
BACKGROUND: Several hydrolyzed cow's milk (CM) formulas are available for avoidance of allergic reactions in CM-allergic children and for prevention of allergy development in high-risk infants. Our aim was to compare CM formulas regarding the presence of immunoreactive CM components, IgE reactivity, allergenic activity, ability to induce T-cell proliferation, and cytokine secretion. METHODS: A blinded analysis of eight CM formulas, one nonhydrolyzed, two partially hydrolyzed (PH), four extensively hydrolyzed (EH), and one amino acid formula, using biochemical techniques and specific antibody probes was conducted...
July 25, 2016: Allergy
https://www.readbyqxmd.com/read/27418957/the-impact-of-the-elimination-diet-on-growth-and-nutrient-intake-in-children-with-food-protein-induced-gastrointestinal-allergies
#12
Rosan Meyer, Claire De Koker, Robert Dziubak, Heather Godwin, Gloria Dominguez-Ortega, Adriana Chebar Lozinsky, Ana-Kristina Skrapac, Yara Gholmie, Kate Reeve, Neil Shah
BACKGROUND: Non immunoglobulin E (IgE) mediated allergies affecting the gastrointestinal tract require an elimination diet to aid diagnosis. The elimination diet may entail multiple food eliminations that contribute significantly to macro- and micro-nutrient intake which are essential for normal growth and development. Previous studies have indicated growth faltering in children with IgE-mediated allergy, but limited data is available on those with delayed type allergies. We therefore performed a study to establish the impact on growth before and after commencing an elimination diets in children with food protein induced non-IgE mediated gastrointestinal allergies...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27396729/antibody-independent-identification-of-bovine-milk-derived-peptides-in-breast-milk
#13
Gianluca Picariello, Francesco Addeo, Pasquale Ferranti, Rita Nocerino, Lorella Paparo, Annalisa Passariello, David C Dallas, Randall C Robinson, Daniela Barile, Roberto Berni Canani
Exclusively breast-fed infants can exhibit clear signs of IgE or non IgE-mediated cow's milk allergy. However, the definite characterization of dietary cow's milk proteins (CMP) that survive the maternal digestive tract to be absorbed into the bloodstream and secreted into breast milk remains missing. Herein, we aimed at assessing possible CMP-derived peptides in breast milk. Using high performance liquid chromatography (HPLC)-high resolution mass spectrometry (MS), we compared the peptide fraction of breast milk from 12 donors, among which 6 drank a cup of milk daily and 6 were on a strict dairy-free diet...
August 10, 2016: Food & Function
https://www.readbyqxmd.com/read/27215624/-food-allergy-and-intolerance-distinction-definitions-and-delimitation
#14
Jörg Kleine-Tebbe, Anja Waßmann-Otto, Hubert Mönnikes
Immunologically mediated hypersensitivity to foods is defined as food allergy, mainly due to immunglobulins of class E (IgE) triggering immediate reactions (type I hypersensitivity) with possible involvement of mucosa, skin, airways, intestinal tract, and the vascular system. Primary food allergy is based on (early) IgE sensitization against animal (e. g., cow's milk, hen's eggs) or plant proteins (e. g. peanut, hazelnut or wheat). In the case of secondary food allergies, IgE against pollen proteins (e...
June 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27133095/changes-in-food-specific-ige-over-time-in-the-national-health-and-nutrition-examination-survey-nhanes
#15
Emily C McGowan, Roger D Peng, Päivi M Salo, Darryl C Zeldin, Corinne A Keet
BACKGROUND: Food allergy prevalence appears to have recently risen, with larger increases among non-Hispanic blacks. However, it is unclear whether these trends represent shifts in recognition of food allergy or in sensitization. OBJECTIVE: The objective of this study was to determine whether sensitization to common food allergens increased in US children from 1988-1994 to 2005-2006 and whether these trends differed by race and/or ethnicity. METHODS: Food-specific immunoglobulin E (IgE; to peanut, milk, egg, and shrimp) was measured by ImmunoCAP in stored sera from subjects aged 6-19 in the National Health and Nutrition Examination Survey (NHANES) III (1988-1994) and was compared with NHANES 2005-2006...
July 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27051548/fpies-reviewing-the-management-of-food-protein-induced-enterocolitis-syndrome
#16
Neha Khanna, Kirtika Patel
Purpose of Review. The aim of this review is to provide a case driven presentation of the presenting features and diagnostic criteria particularly focusing on the management of FPIES. It also summarises the natural history and resolution of cow's milk induced FPIES. Data Sources. OvidSP Database was used to search for literature using the keywords food protein-induced enterocolitis and FPIES. Recent Findings. The diagnosis of FPIES is often delayed following two or more presentations. Symptoms in the acute form include profuse vomiting usually 2-6 hours following ingestion of food...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27028543/levels-of-immunoglobulin-e-specific-to-the-major-food-allergen-and-chemokine-c-c-motif-ligand-ccl-17-thymus-and-activation-regulated-chemokine-and-ccl22-macrophage-derived-chemokine-in-infantile-atopic-dermatitis-on-ishigaki-island
#17
Hitokazu Esaki, Satoshi Takeuchi, Norihiro Furusyo, Kazuhiko Yamamura, Sayaka Hayashida, Gaku Tsuji, Masaki Takemura, Jun Hayashi, Masutaka Furue
Atopic dermatitis (AD) is a multifactorial T-helper (Th)2-mediated skin disease frequently associated with elevated serum immunoglobulin (Ig)E and food allergy is also a Th2- and IgE-mediated adverse immunological reaction. Our previous study indicated the relation of egg allergy history and disease severity of AD. Thus, the purpose of the study was to investigate the levels of IgE specific to major food allergens (egg, milk, wheat) and Th2 chemokines (chemokine [C-C motif] ligand [CCL]17/thymus and activation regulated chemokine [TARC] and CCL22/macrophage-derived chemokine [MDC]) and the relationship between them...
March 30, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/26982575/practice-of-the-treatment-of-milk-allergy-in-the-uk-a-national-audit
#18
David Luyt, M Thirumala Krishnan, Pia Huber, Andrew Clark
BACKGROUND: The management of cow's milk allergy (CMA) includes initial dairy exclusion with suitable dietary substitution, diagnostic challenges where indicated, and supervised re-introduction as the condition resolves. Information on clinician practice is limited. We audited the current practice of clinicians in the UK to evaluate adherence to international guidelines. METHODS: An online questionnaire was sent to all clinicians whose practice included children identified on the national allergy society website...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/26948687/identification-and-characterization-of-dc-sign-binding-glycoproteins-in-allergenic-foods
#19
M Kamalakannan, L M Chang, G Grishina, H A Sampson, M Masilamani
BACKGROUND: DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin) is a C-type lectin receptor expressed on macrophages and dendritic cells. DC-SIGN has high affinity for fucosylated glycans in several plant glycoproteins and pathogens. DC-SIGN is thought to be crucial for the development of allergic sensitization. However, the precise role of DC-SIGN in food allergy pathogenesis is not yet understood. OBJECTIVE: We sought to characterize DC-SIGN-binding glycoproteins in a panel of allergenic and non-allergenic foods...
August 2016: Allergy
https://www.readbyqxmd.com/read/26837607/exploring-racial-differences-in-ige-mediated-food-allergy-in-the-wheals-birth-cohort
#20
Christine L M Joseph, Edward M Zoratti, Dennis R Ownby, Suzanne Havstad, Charlotte Nicholas, Christian Nageotte, Rana Misiak, Robert Enberg, Jerel Ezell, Christine Cole Johnson
BACKGROUND: Suspected food allergies are the cause of more than 200,000 visits to the emergency department annually. Racial differences in the prevalence of food allergy have also been reported, but the evidence is less conclusive. Researchers continue to struggle with the identification of food allergy for epidemiologic studies. OBJECTIVE: To explore racial differences in IgE-mediated food allergy (IgE-FA) in a birth cohort. METHODS: We used a panel of board-certified allergists to systematically identify IgE-FA to egg, milk, or peanut in a multiethnic birth cohort in which patient medical history, patient symptoms, and clinical data were available through 36 months of age...
March 2016: Annals of Allergy, Asthma & Immunology
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