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Non ige milk allergy

Mitsuaki Kimura, Masaki Shimomura, Hideaki Morishita, Takaaki Meguro, Shiro Seto
BACKGROUND: Many Japanese infants with food protein-induced enterocolitis syndrome (FPIES) show eosinophilia, which has been thought to be a characteristic of food protein-induced proctocolitis (FPIP). METHODS: To elucidate the characteristics of eosinophilia in Japanese FPIES patients, 113 infants with non-IgE-mediated gastrointestinal food allergy due to cow's milk were enrolled and classified into FPIES (n = 94) and FPIP (n = 19). RESULTS: The percentage of peripheral blood eosinophils (Eo) was increased in most FPIES patients (median, 7...
September 10, 2016: Allergology International: Official Journal of the Japanese Society of Allergology
Sara Manti, Vassilios Lougaris, Caterina Cuppari, Lucia Tardino, Valeria Dipasquale, Teresa Arrigo, Carmelo Salpietro, Salvatore Leonardi
AIM: To assess the protective role of breast-feeding in infants with CMPA-related AEDS as well as IL-10 utility as marker of disease evolution. METHODS: 64 breast-feeding children with CMPA-related AEDS (31 males and 33 females; mean age 5.56±2.41months; 21 mild AEDS; 25 moderate AEDS; 18 severe AEDS) and 60 artificial feeding babies (33 males and 27 females; mean age 6.01±2.08months; 26 mild AEDS; 19 moderate AEDS; 15 severe AEDS) were evaluated. In all patients serum IL-10 levels were detected...
September 8, 2016: Immunobiology
Grace Mousan, Deepak Kamat
Cow's milk protein allergy (CMPA) is a common condition encountered in children with incidence estimated as 2% to 7.5% in the first year of life. Formula and breast-fed babies can present with symptoms of CMPA. It is important to accurately diagnose CMPA to avoid the consequences of either under- or overdiagnosis. CMPA is classically categorized into immunoglobulin E (IgE)- or non-IgE-mediated reaction that vary in clinical manifestations, diagnostic evaluation, and prognosis. The most commonly involved systems in patients with CMPA are gastrointestinal, skin, and respiratory...
October 2016: Clinical Pediatrics
Jean Christoph Caubet, Ramon Bencharitiwong, Andrew Ross, Hugh A Sampson, M Cecilia Berin, Anna Nowak-Węgrzyn
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy manifesting within 1 to 4 hours of food ingestion with repetitive emesis and lethargy. OBJECTIVE: We sought to characterize immune responses to casein in children with FPIES caused by cow's milk (CM). METHODS: Total IgE and IgM, CM-specific IgG, and casein-specific IgE, IgG, IgG4, and IgM levels, as well as immunoglobulin free light chains, were measured in both patients with active and those with resolved CM-FPIES...
July 15, 2016: Journal of Allergy and Clinical Immunology
P Comberiati, M Landi, A Martelli, G L Piacentini, C Capristo, G Paiola, D G Peroni
BACKGROUND: Allergic enterocolitis, also known as food protein-induced enterocolitis syndrome (FPIES), is an increasingly reported and potentially severe non-IgE mediated food allergy of the first years of life, which is often misdiagnosed due to its non-specific presenting symptoms and lack of diagnostic guidelines. OBJECTIVE: We sought to determine the knowledge of clinical, diagnostic and therapeutic features of FPIES among Italian primary-care paediatricians...
September 2016: Allergologia et Immunopathologia
Heidrun Hochwallner, Ulrike Schulmeister, Ines Swoboda, Margit Focke-Tejkl, Renate Reininger, Vera Civaj, Raffaela Campana, Josef Thalhamer, Sandra Scheiblhofer, Nadja Balic, Friedrich Horak, Markus Ollert, Nikolaos G Papadopoulos, Santiago Quirce, Zsolt Szepfalusi, Udo Herz, Eric A F van Tol, Susanne Spitzauer, Rudolf Valenta
BACKGROUND: Several hydrolyzed cow's milk (CM) formulas are available for avoidance of allergic reactions in CM allergic children and for prevention of allergy development in high risk infants. Our aim was to compare CM formulas regarding the presence of immunoreactive CM components, IgE reactivity, allergenic activity, ability to induce T cell proliferation and cytokine secretion. METHODS: A blinded analysis of eight cow's milk formulas: one non-hydrolyzed, two partially hydrolyzed, four extensively hydrolyzed and one amino acid formula, using biochemical techniques and specific antibody probes was conducted...
July 25, 2016: Allergy
Rosan Meyer, Claire De Koker, Robert Dziubak, Heather Godwin, Gloria Dominguez-Ortega, Adriana Chebar Lozinsky, Ana-Kristina Skrapac, Yara Gholmie, Kate Reeve, Neil Shah
BACKGROUND: Non immunoglobulin E (IgE) mediated allergies affecting the gastrointestinal tract require an elimination diet to aid diagnosis. The elimination diet may entail multiple food eliminations that contribute significantly to macro- and micro-nutrient intake which are essential for normal growth and development. Previous studies have indicated growth faltering in children with IgE-mediated allergy, but limited data is available on those with delayed type allergies. We therefore performed a study to establish the impact on growth before and after commencing an elimination diets in children with food protein induced non-IgE mediated gastrointestinal allergies...
2016: Clinical and Translational Allergy
Gianluca Picariello, Francesco Addeo, Pasquale Ferranti, Rita Nocerino, Lorella Paparo, Annalisa Passariello, David C Dallas, Randall C Robinson, Daniela Barile, Roberto Berni Canani
Exclusively breast-fed infants can exhibit clear signs of IgE or non IgE-mediated cow's milk allergy. However, the definite characterization of dietary cow's milk proteins (CMP) that survive the maternal digestive tract to be absorbed into the bloodstream and secreted into breast milk remains missing. Herein, we aimed at assessing possible CMP-derived peptides in breast milk. Using high performance liquid chromatography (HPLC)-high resolution mass spectrometry (MS), we compared the peptide fraction of breast milk from 12 donors, among which 6 drank a cup of milk daily and 6 were on a strict dairy-free diet...
August 10, 2016: Food & Function
Jörg Kleine-Tebbe, Anja Waßmann-Otto, Hubert Mönnikes
Immunologically mediated hypersensitivity to foods is defined as food allergy, mainly due to immunglobulins of class E (IgE) triggering immediate reactions (type I hypersensitivity) with possible involvement of mucosa, skin, airways, intestinal tract, and the vascular system. Primary food allergy is based on (early) IgE sensitization against animal (e. g., cow's milk, hen's eggs) or plant proteins (e. g. peanut, hazelnut or wheat). In the case of secondary food allergies, IgE against pollen proteins (e...
June 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Emily C McGowan, Roger D Peng, Päivi M Salo, Darryl C Zeldin, Corinne A Keet
BACKGROUND: Food allergy prevalence appears to have recently risen, with larger increases among non-Hispanic blacks. However, it is unclear whether these trends represent shifts in recognition of food allergy or in sensitization. OBJECTIVE: The objective of this study was to determine whether sensitization to common food allergens increased in US children from 1988-1994 to 2005-2006 and whether these trends differed by race and/or ethnicity. METHODS: Food-specific immunoglobulin E (IgE; to peanut, milk, egg, and shrimp) was measured by ImmunoCAP in stored sera from subjects aged 6-19 in the National Health and Nutrition Examination Survey (NHANES) III (1988-1994) and was compared with NHANES 2005-2006...
July 2016: Journal of Allergy and Clinical Immunology in Practice
Neha Khanna, Kirtika Patel
Purpose of Review. The aim of this review is to provide a case driven presentation of the presenting features and diagnostic criteria particularly focusing on the management of FPIES. It also summarises the natural history and resolution of cow's milk induced FPIES. Data Sources. OvidSP Database was used to search for literature using the keywords food protein-induced enterocolitis and FPIES. Recent Findings. The diagnosis of FPIES is often delayed following two or more presentations. Symptoms in the acute form include profuse vomiting usually 2-6 hours following ingestion of food...
2016: Case Reports in Pediatrics
Hitokazu Esaki, Satoshi Takeuchi, Norihiro Furusyo, Kazuhiko Yamamura, Sayaka Hayashida, Gaku Tsuji, Masaki Takemura, Jun Hayashi, Masutaka Furue
Atopic dermatitis (AD) is a multifactorial T-helper (Th)2-mediated skin disease frequently associated with elevated serum immunoglobulin (Ig)E and food allergy is also a Th2- and IgE-mediated adverse immunological reaction. Our previous study indicated the relation of egg allergy history and disease severity of AD. Thus, the purpose of the study was to investigate the levels of IgE specific to major food allergens (egg, milk, wheat) and Th2 chemokines (chemokine [C-C motif] ligand [CCL]17/thymus and activation regulated chemokine [TARC] and CCL22/macrophage-derived chemokine [MDC]) and the relationship between them...
March 30, 2016: Journal of Dermatology
David Luyt, M Thirumala Krishnan, Pia Huber, Andrew Clark
BACKGROUND: The management of cow's milk allergy (CMA) includes initial dairy exclusion with suitable dietary substitution, diagnostic challenges where indicated, and supervised re-introduction as the condition resolves. Information on clinician practice is limited. We audited the current practice of clinicians in the UK to evaluate adherence to international guidelines. METHODS: An online questionnaire was sent to all clinicians whose practice included children identified on the national allergy society website...
2016: International Archives of Allergy and Immunology
M Kamalakannan, L M Chang, G Grishina, H A Sampson, M Masilamani
BACKGROUND: DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin) is a C-type lectin receptor expressed on macrophages and dendritic cells. DC-SIGN has high affinity for fucosylated glycans in several plant glycoproteins and pathogens. DC-SIGN is thought to be crucial for the development of allergic sensitization. However, the precise role of DC-SIGN in food allergy pathogenesis is not yet understood. OBJECTIVE: We sought to characterize DC-SIGN-binding glycoproteins in a panel of allergenic and non-allergenic foods...
August 2016: Allergy
Christine L M Joseph, Edward M Zoratti, Dennis R Ownby, Suzanne Havstad, Charlotte Nicholas, Christian Nageotte, Rana Misiak, Robert Enberg, Jerel Ezell, Christine Cole Johnson
BACKGROUND: Suspected food allergies are the cause of more than 200,000 visits to the emergency department annually. Racial differences in the prevalence of food allergy have also been reported, but the evidence is less conclusive. Researchers continue to struggle with the identification of food allergy for epidemiologic studies. OBJECTIVE: To explore racial differences in IgE-mediated food allergy (IgE-FA) in a birth cohort. METHODS: We used a panel of board-certified allergists to systematically identify IgE-FA to egg, milk, or peanut in a multiethnic birth cohort in which patient medical history, patient symptoms, and clinical data were available through 36 months of age...
March 2016: Annals of Allergy, Asthma & Immunology
Julian F Guest, Diana Weidlich, J Ignacio Mascuñan Díaz, Juan J Díaz, Pedro Manuel Ojeda, J Pablo Ferrer-González, David Gil, Isabel Onrubia, Pedro Rincón Victor
OBJECTIVE: To estimate the cost-effectiveness of using an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (eHCF + LGG; Nutramigen LGG) as a first-line management for cow's milk allergy compared with eHCF alone, and amino acid formulae in Spain, from the perspective of the Spanish National Health Service (SNS). METHODS: Decision modeling was used to estimate the probability of immunoglobulin E (IgE)-mediated and non-IgE-mediated allergic infants developing tolerance to cow's milk by 18 months...
2015: ClinicoEconomics and Outcomes Research: CEOR
Stephanie A Leonard, Anna Nowak-Węgrzyn
Food protein-induced enterocolitis syndrome (FPIES) is a rare, non-immunoglobulin E-mediated gastrointestinal food allergy primarily diagnosed in infancy, but has also been reported in older children and adults. Acute FPIES reactions typically present with delayed, repetitive vomiting, lethargy, and pallor within 1 to 4 hours of food ingestion. Chronic FPIES typically presents with protracted vomiting and/or diarrhea, and weight loss or poor growth. Common foods triggering FPIES include cow's milk, soy, rice, oats, fish, and egg...
December 2015: Pediatric Clinics of North America
Sonia Mazigh, Salem Yahiaoui, Rania Ben Rabeh, Ilhem Fetni, Azza Sammoud
BACKGROUND: Cow's milk protein allergy (CMPA) can be responsible of a variety of symptoms and can be caused by IgE or non-IgEmediated reactions. The remaining questions concern the diagnosis (what are the most suggestive clinical manifestations, the laboratory evaluations which play a supporting role, and the management of CMPA in breast fed infants and formula-fed infants. METHODS: Review of the pub med, science direct, Cochrane library, using the key words cow's milk protein allergy, guideline, and child...
April 2015: La Tunisie Médicale
Carlos Trillo Belizón, Eduardo Ortega Páez, Antonio F Medina Claros, Isabel Rodríguez Sánchez, Ana Reina González, Rafael Vera Medialdea, José Manuel Ramón Salguero
INTRODUCTION: The aim of the study was to assess the use of faecal calprotectin (FCP) in infants with signs and symptoms of non-IgE-mediated cow's milk protein allergy (CMA) for both diagnosis and prediction of clinical response at the time of withdrawal of milk proteins. PATIENTS AND METHODS: A one year prospective study was conducted on 82 infants between 1 and 12 months of age in the Eastern area of Málaga-Axarquía, of whom 40 of them had been diagnosed with non-IgE-mediated CMA (with suggestive symptoms and positive response to milk withdrawal), 12 not diagnosed with CMA, and 30 of them were the control group...
June 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Michael R Goldberg, Liat Nachshon, Michael Y Appel, Arnon Elizur, Michael B Levy, Eli Eisenberg, Hugh A Sampson, Yitzhak Katz
BACKGROUND: Patients with IgE-mediated cow's milk allergy who are nonreactive to baked milk (BM) can be desensitized with BM to promote tolerance to unheated milk (UM). OBJECTIVE: We sought to test whether patients who are BM reactive can progress in BM oral immunotherapy (OIT) and become desensitized to UM as well. METHODS: Fifteen patients (>4 years) who previously failed to complete our milk OIT program were enrolled into the BM OIT protocol...
December 2015: Journal of Allergy and Clinical Immunology
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