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Metastatic spinal tumor

Ben Wang, Liang Jiang, Feng Wei, Xiao Guang Liu, Zhong Jun Liu
RATIONALE: Vertebral hemangiomas (VHs), one of the most common benign tumors of the spine, can be aggressive, which is a rare condition and causes neurological deficits. Pregnancy is related to the worsening of aggressive VHs. The diagnosis and treatment of aggressive VHs remain challenging, especially for pregnant cases. PATIENT CONCERNS: We report 3 cases of aggressive VH in women who developed progressive neurological deficits during pregnancy among 95 patients treated for aggressive VH in our hospital in the past 15 years...
October 2018: Medicine (Baltimore)
Imza Feroz, Rumana Hamid Makhdoomi, Nayil Khursheed, Feroze Shaheen, Parveen Shah
Introduction: Computed tomography (CT)-guided biopsy of spine is currently a valuable diagnostic tool and effective technique for diagnosing and planning a proper therapeutic strategy for certain spinal lesions. The reported diagnostic accuracy of core biopsy ranges from 77% to 97%. Materials and Methods: We included all patients with spinal lesions suspicious of metastasis on magnetic resonance imaging, who presented between May 2012 and April 2014 and underwent CT-guided biopsy in our study...
July 2018: Asian Journal of Neurosurgery
Katharina Rosian, Katharina Hawlik, Brigitte Piso
BACKGROUND: Metastatic spinal lesions are difficult-to-treat entities that are most commonly associated with pain and severely reduced health-related quality of life (HRQoL). Within the last 5 to 10 years, radiofrequency ablation (RFA) has emerged as an option in the palliative treatment of vertebral metastases. OBJECTIVES: Our review aims to evaluate the clinical effectiveness and safety of RFA, mostly in combination with vertebroplasty, in patients with painful vertebral metastases...
September 2018: Pain Physician
Maksim Liaukovich, Susan Wu, Sydney Yoon, Jeff Schaffer, Jen C Wang
BACKGROUND: Hepatocellular carcinoma is a common malignancy in Asia. It is associated with chronic hepatitis B virus or hepatitis C virus infection and alcoholic hepatitis. Commonly, the tumor metastasizes to the lungs, regional lymph nodes, and bone. Recently, the incidence of metastatic spinal cord compression caused by primary hepatocellular carcinoma has been reported more frequently due to improved diagnosis and therapeutic modalities. The presentation of primary hepatocellular carcinoma with spinal cord compression is very rare...
September 30, 2018: Journal of Medical Case Reports
Jiang-Tao Feng, Xiong-Gang Yang, Feng Wang, Kun-Chi Hua, Yong-Heng Liu, Yong-Cheng Hu, Hao Zhang, Li Yang, Ming-You Xu, Hao-Ran Zhang
BACKGROUND: Contradictory results were reported regarding to the prognostic effect of ambulatory status in patients with metastatic spinal cord compression (MSCC). The aim of this study was to investigate whether ambulatory status is an significant predictor of overall survival in patients with MSCC, and to distinguish the differences of predictors between patients ambulatory and non-ambulatory pre-operation. METHODS: Three clinical centers were retrospectively reviewed to identify patients operated for MSCC between 2005 and 2015...
September 24, 2018: World Neurosurgery
Kevin Phan, Zoe B Cheung, Khushdeep S Vig, Awais K Hussain, Mauricio C Lima, Jun S Kim, John Di Capua, Samuel K Cho
Study Design: Retrospective cohort study. Objectives: To evaluate age as an independent predictive factor for perioperative morbidity and mortality in patients undergoing surgical decompression for metastatic cervical and thoracic spinal tumors using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database from 2011 to 2014. Methods: We identified 1673 adult patients undergoing excisional laminectomy of cervical and thoracic extradural tumors...
August 2018: Global Spine Journal
Audrey Petit, Amandine Rubio, Chantal Durand, Christian Piolat, Cécile Perret, Anne Pagnier, Dominique Plantaz, Hervé Sartelet
Spinal cord compression in Wilms' tumor (WT) is an extremely rare event that can have a very poor prognosis if not taken care of rapidly. Most cases reported in the literature involve widely metastatic patient with bone or paraspinal metastases or occasionally intradural metastasis. Here, we present the case of a 3-year-old girl of WT confirmed by biopsy, with spinal cord compression due to the direct contiguous spread of a tumor through 2 vertebral foramina. Abdominal ultrasonography and magnetic resonance imaging performed for an abdominal mass revealed a large heterogeneous tumor near the upper pole of the left kidney...
2018: Case Reports in Pediatrics
Hannah E Gilder, Ross C Puffer, Mohamad Bydon, Robert J Spinner
OBJECTIVE: In this study, the authors sought to compare tumors with intradural extension to those remaining in the epidural or paraspinal space with the hypothesis that intradural extension may be a mechanism for seeding of the CSF with malignant cells, thereby resulting in higher rates of CNS metastases and shorter overall survival. METHODS: The authors searched the medical record for cases of malignant peripheral nerve sheath tumors (MPNSTs) identified from 1994 to 2017...
September 21, 2018: Journal of Neurosurgery. Spine
Mark L Higdon, Charles J Atkinson, Kelley V Lawrence
Most oncologic emergencies can be classified as metabolic, hematologic, structural, or treatment related. Tumor lysis syndrome is a metabolic emergency that presents as severe electrolyte abnormalities. Stabilization is focused on vigorous rehydration, maintaining urine output, and lowering uric acid levels. Hypercalcemia of malignancy, which is associated with poor outcomes, is treated with aggressive rehydration, intravenous bisphosphonates, and subspecialty consultation. Syndrome of inappropriate antidiuretic hormone should be suspected if a patient with cancer has hyponatremia...
June 1, 2018: American Family Physician
Sam Yeol Chang, Jae Hong Ha, Sang Gyo Seo, Bong-Soon Chang, Choon-Ki Lee, Hyoungmin Kim
STUDY DESIGN: This was a retrospective cohort study. PURPOSE: We evaluated the predictive value of the Spinal Instability Neoplastic Score (SINS) system for spinal adverse events (SAEs) in patients with single spinal metastatic tumor. OVERVIEW OF LITERATURE: The SINS system was developed to assess spinal instability in patients with single metastatic spinal tumor. However, the system's potential predictive value for SAEs has been partially studied...
October 2018: Asian Spine Journal
Amer Sebaaly, Ahmed Najjar, Zhi Wang, Ghassan Boubez, Laura Masucci, Daniel Shedid
STUDY DESIGN: Retrospective case series. PURPOSE: To evaluate the clinical and radiological efficacy of anterolateral kyphoplasty for cervical spinal metastasis. OVERVIEW OF LITERATURE: Although the spine is the third most common site of tumor metastasis, the cervical spine is the least commonly affected (incidence, 10%-15%). Surgical decompression is highly challenging because of the proximity of neural and vascular elements. Kyphoplasty for cervical spine metastasis has been described in small case reports with promising results...
October 2018: Asian Spine Journal
Pengfei Qiao, Pengfei Zhao, Yang Gao, Yuzhen Bai, Guangming Niu
Objective: In the present study, spinal metastatic tumors, brucellar spondylitis and spinal tuberculosis were quantitatively analyzed using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to assess the value of DCE-MRI in the differential diagnosis of these diseases. Methods: Patients with brucellar spondylitis, spinal tuberculosis or a spinal metastatic tumor (30 cases of each) received conventional MRI and DCE-MRI examination. The volume transfer constant (Ktrans ), rate constant (Kep ), extravascular extracellular volume fraction (Ve ) and plasma volume fraction (Vp ) of the diseased vertebral bodies were measured on the perfusion parameter map, and the differences in these parameters between the patients were compared...
August 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
Shuzhong Liu, Xi Zhou, An Song, William A Li, Radhika Rastogi, Yipeng Wang, Yong Liu
RATIONALE: Malignant pheochromocytoma in the spine is a rare disease without standard curative managements so far. The objective of this article is to report a very rare case of malignant pheochromocytoma with sacrum metastases causing severe lumbosacral pain, which was presented with acute radiculopathy and treated with three operations combined with cement augmentation and stabilization. The management of these unique cases has yet to be well-documented. PATIENT CONCERNS: A 58-year-old man presented with lumbosacral pain, radiating pain and numbness of the right extremity...
August 2018: Medicine (Baltimore)
Wei Xiong, Yong Xu, Zhong Fang, Feng Li
OBJECTIVE: To report and describe a modified posterior-only approach (paraspinal approach) for TES of lumbar spinal tumors. METHODS: From February 2013 to June 2014 at our hospital, five patients received TES through a posterior-only paraspinal approach were studied retrospectively, and time required for surgery, blood loss , complications, neurological outcomes and degree of resection were recorded for evaluating the efficacy of this surgical method. RESULTS: There were a total of 5 patients, three men and two women, with lumbar spinal tumors performed TES through the paraspinal approach...
August 22, 2018: World Neurosurgery
Jiro Ichikawa, Tetsuro Ohba, Hiroaki Kanda, Koji Fujita, Shigeto Ebata, Hirotaka Haro
Case: Generally, well-differentiated liposarcoma (WDL) has recurrence potential but lacks metastatic potential. We present a rare case of spinal metastasis of WDL component in retroperitoneal dedifferentiated liposarcoma (DDL) treated by tumor curettage and L1 laminectomy followed by percutaneous pedicle screw fixation. Histological examination showed metastasis of the WDL component of DDL. The patient was ambulatory until death. Conclusion: To our knowledge, no case of spinal metastasis of WDL component in retroperitoneal DDL has been reported...
2018: Case Reports in Orthopedics
Marissa Guo, Kristen L Kolberg, Eleanor C Smith, Brandon W Smith, Jonah E Yousif, Jason L Kessler, Joseph R Linzey, Anda-Alexandra Calinescu, Gregory A Clines, Daniel E Spratt, Nicholas J Szerlip
BACKGROUND: Spinal metastases pose significant morbidity. For many histologies, the spine is a frequent site for bone metastases. This predilection is not fully understood, and there are conflicting reports regarding the distribution within the vertebral body itself. Knowing this distribution will give clues as to the underlying biologic reason for this increased incidence in the spine and lead to a better understanding of tumor dispersion and growth. METHODS: We retrospectively examined magnetic resonance imaging scans of patients undergoing radiation to the spine from 2015 to 2017 for spinal metastases...
August 13, 2018: World Neurosurgery
Jonathan G Hobbs, Akash S Patel, Anisse N Chaker, Nazmul Hasan, Prateek Kumar, Edwin Ramos, Ankit I Mehta
BACKGROUND: Steroid administration is part of a standard treatment regimen in metastatic spinal cord compression, though the appropriate dose, duration, efficacy, and risks remain controversial. OBJECTIVE: To analyze the risk of preoperative steroid use on 30-d mortality in surgical metastatic spinal tumors with dissemination disease using a large multicenter national database. METHODS: Adult patients who underwent surgical treatment for metastatic spine tumors between 2005 and 2014 were identified in the American College of Surgeons National Surgical Quality Improvement Program database...
August 3, 2018: Neurosurgery
Emma Maria Dunne, Ian Mark Fraser, Mitchell Liu
Stereotactic body radiation therapy (SBRT) also referred to as stereotactic ablative radiotherapy (SABR), is a technique which has emerged over the past two decades due to improvements in radiation technology. Unlike conventional external beam radiotherapy (cEBRT) which traditionally delivers radiation in small doses [approximately 2 Gray (Gy) per fraction] over several weeks, SBRT, typically delivered in one to eight fractions, is a technique whereby potentially ablative doses of radiotherapy (usually 7.5-20 Gy per fraction) can be delivered with steeper dose gradients and sub millimetre precision, minimising risk to surrounding normal tissues...
July 2018: Annals of Translational Medicine
A Tomasian, T J Hillen, R O Chang, J W Jennings
BACKGROUND AND PURPOSE: Percutaneous radiofrequency ablation combined with vertebral augmentation has emerged as a minimally invasive treatment for patients with vertebral metastases who do not respond to or have contraindications to radiation therapy. The prevalence of posterior vertebral body metastases presents access and treatment challenges in the unique anatomy of the spine. The purpose of this study was to evaluate the safety and efficacy of simultaneous bipedicular radiofrequency ablation using articulating bipolar electrodes combined with vertebral augmentation for local tumor control of spinal metastases...
September 2018: AJNR. American Journal of Neuroradiology
Vayara P Vinodh, Senthil K Rajapathy, Pulivendhan Sellamuthu, Regunath Kandasamy
Background: Reperfusion injury of the spinal cord or "white cord syndrome" refers to the sudden onset of neurological deterioration after spinal decompressive surgery. Associated magnetic resonance (MR) findings only include focal hyperintensity on T2-weighted images without any other pathological changes. Case Description: A patient with cervical stenosis secondary to metastatic tumor in the intradural and extradural compartments presented with lower limb paraparesis...
2018: Surgical Neurology International
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