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https://www.readbyqxmd.com/read/30101717/novel-tetrahydrobenzo-b-thiophene-compounds-exhibit-anticancer-activity-through-enhancing-apoptosis-and-inhibiting-tyrosine-kinase
#1
Souad A El-Metwally, Ali K Khalil, Abeer M El-Naggar, Wael M El-Sayed
ackground: Developing new chemotherapeutic agents with molecular targets, larger margin of safety against normal cells and low cost is the target many scientists try to achieve. OBJECTIVE: The present study was undertaken to investigate the anticancer activity of a novel series of thiophene compounds and the molecular mechanisms associated. METHODS: A series of novel heterocyclic compounds including pyrimidine derivatives (2, 3, 4, 5 8, 11, 12, 13, 14, and 15), thiophene derivatives (6, 7, and 10) and oxoisothiazolidine derivative (9) was synthesized from 4,5,6,7-tetrahydrobenzo[b] thiophene (1)...
August 13, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/30081600/modified-nigella-sativa-seeds-as-a-novel-efficient-natural-adsorbent-for-removal-of-methylene-blue-dye
#2
Souad Rakass, Ahmed Mohmoud, Hicham Oudghiri Hassani, Mostafa Abboudi, Fethi Kooli, Fahd Al Wadaani
The aim of this work was to investigate the use of modified nigella sativa seeds (MNS) for removing of methylene blue (MB) dye from aqueous solution. The nigella sativa (NS) seeds have been pre-treated at different temperatures and periods of time. The maximum adsorption of MB was achieved using NS sample washed with distilled water pre-heated at 65 °C for one hour, then ground to 250 µm particle size (MNS-4). Different parameters were modified to optimize the removal process of MB using MNS-4, such as contact times, temperatures, initial dye concentrations, adsorbent doses, and pH of the solution...
August 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30037049/management-of-leishmaniases-in-the-era-of-climate-change-in-morocco
#3
Kahime Kholoud, Sereno Denis, Bounoua Lahouari, Moulay Abdelmonaim El Hidan, Bouhout Souad
The proliferation of vector-borne diseases are predicted to increase in a changing climate and Leishmaniases, as a vector-borne diseases, are re-emerging diseases in several regions of the world. In Morocco, during the last decade, a sharp increase in cutaneous leishmaniases cases has been reported. Nevertheless, in Morocco, leishmaniases are a major public health problem, and little interest was given to climate change impacts on the distribution and spread of these diseases. As insect-borne diseases, the incidence and distribution of leishmaniases are influenced by environmental changes, but also by several socio-economic and cultural factors...
July 20, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30005800/harmful-epiphytic-dinoflagellate-assemblages-on-macrophytes-in-the-gulf-of-tunis
#4
Mohamed Amine Hachani, Amel Dhib, Afef Fathalli, Boutheina Ziadi, Souad Turki, Lotfi Aleya
The spatio-temporal distribution of epiphytic and planktonic microalgae coupled with environmental factors was investigated for a one-year period in the Gulf of Tunis (northeastern Tunisia). Harmful microalgae assemblages were dominated by three toxic epiphytic dinoflagellates: Ostreopsis sp., Prorocentrum lima and Coolia monotis. They were observed, both on macrophytes (1.03 × 105 cells g-1 FW ; 1.3 × 104 cells g-1 FW and 865 cells g-1 FW, respectively) and in the water column (2.35 × 104 cells L-1 ; 3...
July 2018: Harmful Algae
https://www.readbyqxmd.com/read/30005374/mechanisms-of-the-bactericidal-effects-of-nitrate-and-nitrite-in-cured-meats
#5
REVIEW
Didier Majou, Souad Christieans
For cured meat products, nitrite is recognized for its antimicrobial effects against pathogenic bacteria, even though the specific inhibitory mechanisms are not well known. Nitrite contributes to oxidative stress by being the precursor of peroxynitrite (ONOO- ), which is the major strong oxidant. Thus, bacterial stress (highly pH-very low partial pressure of oxygen-dependent) is enhanced by the nitrate-nitrite-peroxynitrite system which is also highly pH- and low partial pressure of oxygen-dependent. Nitrite is a hurdle technology which effectiveness depends on several other hurdle technologies including sodium chloride (accelerating the autoxidation of oxymyoglobin and promote peroxynitrite formation), ascorbate (increasing ONOO- synthesis), and Aw...
November 2018: Meat Science
https://www.readbyqxmd.com/read/29988004/accuracy-of-a-rapid-diagnostic-test-based-on-antigen-detection-for-the-diagnosis-of-cutaneous-leishmaniasis-in-patients-with-suggestive-skin-lesions-in-morocco
#6
Issam Bennis, Kristien Verdonck, Nora El Khalfaoui, Myriam Riyad, Hajiba Fellah, Jean-Claude Dujardin, Hamid Sahibi, Souad Bouhout, Gert Van der Auwera, Marleen Boelaert
In rural areas in Morocco, diagnosing cutaneous leishmaniasis (CL) can be challenging. We evaluated the accuracy of a rapid diagnostic test (RDT) based on antigen detection, CL Detect Rapid Test™ (Inbios International Inc., Seattle, WA), in this setting. We consecutively recruited patients with new skin ulcers in nine primary health centers. We took a dental broach sample for the RDT and two other tissue samples by scraping the border and center of the lesion with a scalpel and smearing it on a slide. We duplicated each smear by pressing a clean slide against it and processed the slides by using microscopy, polymerase chain reaction (PCR) internal transcribed spacer 1, and kDNA minicircle PCR...
July 9, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29951798/unusual-proximal-fragment-migration-of-an-os-peroneum-fracture-with-associated-peroneus-longus-tendon-injury-a-tree-often-hides-a-forest
#7
Sammy Tawk, Frédéric Lecouvet, Dan Constantin Putineanu, Souad Acid
We report the case of a 55-year-old male patient who presented to the emergency department after sustaining a right ankle trauma. Swelling and tenderness of the lateral aspect of the right ankle were present on physical examination without evidence of motor or sensory deficit. Ankle radiographs were performed and showed two bony fragments, the first located postero-inferiorly to the cuboid bone while the second was adjacent to the tip of the lateral malleolus. The diagnosis of an os peroneum fracture was made with high suspicion of an associated peroneus longus tendon rupture...
June 27, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29939388/prevalence-of-consumption-of-psychoactive-substances-amongst-dockers
#8
Omar Laraqui, Nadia Manar, Salwa Laraqui, Tarik Ghailan, Souad Charioui, Frédéric Deschamps, Chakib El Houssine Laraqui
BACKGROUND: Dockers in the port facilities are exposed to significant psychosocial risks (stress, suffering at work, etc.) related to heavy organisational, environmental, physical, chemical constraints, etc. These workers are particularly affected by the consumption of psychoactive substances because of the dangerousness and complexity of their work. To what extent can these numerous occupational risks be at the origin of behaviour favouring the consumption of psychoactive substances? However, in our country no study has investigated toxic habits in this population...
2018: International Maritime Health
https://www.readbyqxmd.com/read/29930395/peri-implantitis-associated-methanogens-a-preliminary-report
#9
Souad Belkacemi, Anthony Mazel, Delphine Tardivo, Patrick Tavitian, Grégory Stephan, Giancarlo Bianca, Elodie Terrer, Michel Drancourt, Gérard Aboudharam
Methanogens have already been described in periodontitis but not in peri-implantitis. Thirty peri-implantitis samples and 28 control samples were collected in 28 consenting peri-implantitis patients. PCR-sequencing of the 16S rRNA gene was used as a broad-spectrum screening method and results were further confirmed by real-time quantitative PCR targeting the mcrA genes. Results showed a methanogen community dominated by Methanobrevibacter oralis in 31/58 (51%) samples including 16/28 (57%) control samples and 15/30 (50%) peri-implantitis samples...
June 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29930244/ibd-risk-loci-are-enriched-in-multigenic-regulatory-modules-encompassing-putative-causative-genes
#10
Yukihide Momozawa, Julia Dmitrieva, Emilie Théâtre, Valérie Deffontaine, Souad Rahmouni, Benoît Charloteaux, François Crins, Elisa Docampo, Mahmoud Elansary, Ann-Stephan Gori, Christelle Lecut, Rob Mariman, Myriam Mni, Cécile Oury, Ilya Altukhov, Dmitry Alexeev, Yuri Aulchenko, Leila Amininejad, Gerd Bouma, Frank Hoentjen, Mark Löwenberg, Bas Oldenburg, Marieke J Pierik, Andrea E Vander Meulen-de Jong, C Janneke van der Woude, Marijn C Visschedijk, Mark Lathrop, Jean-Pierre Hugot, Rinse K Weersma, Martine De Vos, Denis Franchimont, Severine Vermeire, Michiaki Kubo, Edouard Louis, Michel Georges
GWAS have identified >200 risk loci for Inflammatory Bowel Disease (IBD). The majority of disease associations are known to be driven by regulatory variants. To identify the putative causative genes that are perturbed by these variants, we generate a large transcriptome data set (nine disease-relevant cell types) and identify 23,650 cis-eQTL. We show that these are determined by ∼9720 regulatory modules, of which ∼3000 operate in multiple tissues and ∼970 on multiple genes. We identify regulatory modules that drive the disease association for 63 of the 200 risk loci, and show that these are enriched in multigenic modules...
June 21, 2018: Nature Communications
https://www.readbyqxmd.com/read/29921733/aromatase-acetylation-patterns-and-altered-activity-in-response-to-sirtuin-inhibition
#11
Deborah Molehin, Isabel Castro-Piedras, Monica Sharma, Souad R Sennoune, Daphne Arena, Pulak R Manna, Kevin Pruitt
Aromatase, a cytochrome P450 member, is a key enzyme involved in estrogen biosynthesis and is dysregulated in the majority of breast cancers. Studies have shown that lysine deacetylase inhibitors (KDI) decrease aromatase expression in cancer cells, yet many unknowns remain regarding the mechanism by which this occurs. While advances have been made to clarify factors involved in the transcriptional regulation of the aromatase gene (CYP19A1). Yet, despite aromatase being a primary target for breast cancer therapy, its post-translational regulation has been virtually unexplored...
June 19, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29914133/preparation-and-characterization-of-%C3%AE-zinc-molybdate-catalyst-efficient-sorbent-for-methylene-blue-and-reduction-of-3-nitrophenol
#12
Hicham Oudghiri-Hassani, Souad Rakass, Mostafa Abboudi, Ahmed Mohmoud, Fahd Al Wadaani
Zinc molybdate (ZnMoO₄) was prepared by thermal decomposition of an oxalate complex under a controlled temperature of 500 °C. Analyses of the oxalate complex were carried out using Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). On the other hand, analyses of the synthesized zinc molybdate were carried out by X-ray diffraction (XRD), transmission electron microscopy (TEM), and Brunauer-Emmett-Teller technique (BET). The efficiency of the synthesized catalyst was tested with the reduction reaction of 3-nitrophenol (3-NP), and was also applied as a sorbent for methylene blue dye (MB) in aqueous solutions...
June 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29888790/sm-p80-based-vaccine-trial-in-baboons-efficacy-when-mimicking-natural-conditions-of-chronic-disease-praziquantel-therapy-immunization-and-schistosoma-mansoni-re-encounter
#13
Arif J Siddiqui, Adebayo J Molehin, Weidong Zhang, Pramodh K Ganapathy, Eunjee Kim, Juan U Rojo, Whitni K Redman, Souad R Sennoune, Justin Sudduth, Jasmin Freeborn, Derick Hunter, Kameswara R Kottapalli, Pratibha Kottapalli, Ruwanthi Wettashinghe, Govert J van Dam, Paul L A M Corstjens, James F Papin, David Carey, Workineh Torben, Gul Ahmad, Afzal A Siddiqui
Sm-p80-based vaccine efficacy for Schistosoma mansoni was evaluated in a baboon model of infection and disease. The study was designed to replicate a human vaccine implementation scenario for endemic regions in which vaccine would be administered following drug treatment of infected individuals. In our study, the Sm-p80-based vaccine reduced principal pathology producing hepatic egg burdens by 38.0% and egg load in small and large intestines by 72.2% and 49.4%, respectively, in baboons. Notably, hatching rates of eggs recovered from liver and small and large intestine of vaccinated animals were significantly reduced, by 60...
June 11, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29875927/descriptive-study-of-triple-negative-breast-cancer-in-eastern-algeria
#14
Haddad Souad, Frimeche Zahia, Lakehal Abdelhak, Sifi Karima, Satta Dalila, Abadi Noureddine
Introduction: Triple-negative breast cancer (TNBC) is characterized by the lack of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 (HER-2) expression. It is aggressive and most common in African women. In this study we identified the frequency, clinical an pathological characteristics of this type in a cohort of women in Eastern Algeria. Methods: We conducted a retrospective study between January 2010 and December 2015 at the regional hospital of Constantine in eastern Algeria...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29858488/identification-of-mospd2-a-novel-scaffold-for-endoplasmic-reticulum-membrane-contact-sites
#15
Thomas Di Mattia, Léa P Wilhelm, Souade Ikhlef, Corinne Wendling, Danièle Spehner, Yves Nominé, Francesca Giordano, Carole Mathelin, Guillaume Drin, Catherine Tomasetto, Fabien Alpy
Membrane contact sites are cellular structures that mediate interorganelle exchange and communication. The two major tether proteins of the endoplasmic reticulum (ER), VAP-A and VAP-B, interact with proteins from other organelles that possess a small VAP-interacting motif, named FFAT [two phenylalanines (FF) in an acidic track (AT)]. In this study, using an unbiased proteomic approach, we identify a novel ER tether named motile sperm domain-containing protein 2 (MOSPD2). We show that MOSPD2 possesses a Major Sperm Protein (MSP) domain which binds FFAT motifs and consequently allows membrane tethering in vitro MOSPD2 is an ER-anchored protein, and it interacts with several FFAT-containing tether proteins from endosomes, mitochondria, or Golgi...
July 2018: EMBO Reports
https://www.readbyqxmd.com/read/29844217/the-ampk-agonist-5-aminoimidazole-4-carboxamide-ribonucleotide-aicar-but-not-metformin-prevents-inflammation-associated-cachectic-muscle-wasting
#16
Derek T Hall, Takla Griss, Jennifer F Ma, Brenda Janice Sanchez, Jason Sadek, Anne Marie K Tremblay, Souad Mubaid, Amr Omer, Rebecca J Ford, Nathalie Bedard, Arnim Pause, Simon S Wing, Sergio Di Marco, Gregory R Steinberg, Russell G Jones, Imed-Eddine Gallouzi
Activation of AMPK has been associated with pro-atrophic signaling in muscle. However, AMPK also has anti-inflammatory effects, suggesting that in cachexia, a syndrome of inflammatory-driven muscle wasting, AMPK activation could be beneficial. Here we show that the AMPK agonist AICAR suppresses IFNγ/TNFα-induced atrophy, while the mitochondrial inhibitor metformin does not. IFNγ/TNFα impair mitochondrial oxidative respiration in myotubes and promote a metabolic shift to aerobic glycolysis, similarly to metformin...
July 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29790051/probabilistic-risk-based-pollution-prevention-model-for-a-foundry-a-case-study-of-casting
#17
Souad Ahmed Benromdhane
Hazardous air pollutants from industrial activities have long been associated with serious health effects. Traditional health risk assessment uses point estimates of inhalation concentrations based on standard Gaussian diffusion models with steady-state emission rate assumptions. This traditional approach was criticized because it does not account for variability and thus leading to a potential overestimate of the health risk from the batch processes. To overcome this deficiency, a probabilistic risk assessment model is proposed...
July 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29776794/-obstructive-sleep-apnea-syndrome-in-woman-knowing-its-specificities-for-a-better-management
#18
Souad Sediri, Anne Laure Madika, Jean Philippe Baguet, Anne Mallart, Christelle Charley-Monaca, Claire Mounier Vehier
Cardiovascular diseases are the first cause of death in women. Their frequency is underestimated because of their atypical feminine clinical presentation. The pathway "heart, arteries and women", initiated at Lille's hospital center in 2013, was designed to improve pluridisciplinar approaches for women. Thus, obstructive sleep apnea (OSA), known as a metabolic risk factor, was studied in several works. In post-menopausal women with cardiovascular risk, frequency of OSA seems underestimated. Clinical presentation of OSA in feminine patients can be misleading, and its screening seems essential, in light of its major cardiovascular impact...
June 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29775706/purification-and-characterization-of-an-organic-solvent-tolerant-and-detergent-stable-lipase-from-haloferax-mediterranei-cncmm-50101
#19
Siham Akmoussi-Toumi, Souad Khemili-Talbi, Imen Ferioune, Salima Kebbouche-Gana
The present study investigates the purification and biochemical characterization of an extracellular lipase (HML) from Haloarchaea Haloferax mediterranei strain ATS1, isolated from the Sebkha (Medea, Algeria). The pure protein was obtained with ammonium sulfate precipitation (40-70%)-dialysis and UNO Q-6 FPLC, and characterized biochemically. Matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF/MS) analysis revealed that the purified enzyme was a monomer, with a molecular mass of 45,011...
September 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29759140/the-involvement-of-neuroinflammation-and-necroptosis-in-the-hippocampus-during-vascular-dementia
#20
Mourad Belkhelfa, Narimene Beder, Daya Mouhoub, Manel Amri, Rafa Hayet, Nabila Tighilt, Souad Bakheti, Soraya Laimouche, Djamel Azzouz, Rachid Belhadj, Chafia Touil-Boukoffa
The prevalence of vascular dementia is increasing at an alarming rate. The Confirmation of the clinical diagnosis of vascular dementia depends on post-mortem examination of the brain. In our study, we investigated the vascular disease and neuroinflammation during vascular dementia. Our results showed a β-amyloid deposits, neovascularization, neuronal hypertrophy and neuroinflammation in the hippocampus tissue. Interestingly, the neuroinflammation was characterized by a higher expression of TNF-α, IL-1β, TGF-β and iNOS which are TLR4/RelA pathway dependent...
July 15, 2018: Journal of Neuroimmunology
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