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https://www.readbyqxmd.com/read/30486882/sar228810-an-antibody-for-protofibrillar-amyloid-%C3%AE-peptide-designed-to-reduce-the-risk-of-amyloid-related-imaging-abnormalities-aria
#1
Laurent Pradier, Véronique Blanchard-Brégeon, Andrees Bohme, Thomas Debeir, Jean Menager, Patrick Benoit, Pascal Barneoud, Véronique Taupin, Philippe Bertrand, Philippe Dugay, Béatrice Cameron, Yi Shi, Souad Naimi, Marc Duchesne, Marie Gagnaire, Tim Weeden, Tara Travaline, David Reczek, Leonard Khiroug, Mohamed Slaoui, Pascale Brunel, Hidehiro Fukuyama, Jeffrey Ravetch, Thierry Canton, Caroline Cohen
BACKGROUND: Anti-amyloid β (Aβ) immunotherapy represents a major area of drug development for Alzheimer's disease (AD). However, Aβ peptide adopts multiple conformations and the pathological forms to be specifically targeted have not been identified. Aβ immunotherapy-related vasogenic edema has also been severely dose limiting for antibodies with effector functions binding vascular amyloid such as bapineuzumab. These two factors might have contributed to the limited efficacy demonstrated so far in clinical studies...
November 28, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/30483861/gadolinium-chloride-attenuates-acetic-acid-evoked-colitis-in-mice-by-reducing-neutrophil-infiltration-and-pro-oxidative-enzyme-activity
#2
Meriem Ferrat, Hichem Moulahoum, Belkacem Mohamed Amine Boumaza, Souad Mouzaoui, Axel Périanin, Bahia Djerdjouri
This study investigated the potential of gadolinium chloride (GdCl3 ), an inhibitor of kupffer cells on the myeloperoxidase (MPO) function, both in vivo on colon inflammation model and in vitro on thioglycollate-elicited peritoneal neutrophils. Colon inflammation was induced in mice (n = 7) by 4% acetic acid (AA) enema. GdCl3 (10 mg/kg) treatment was given 24 h before AA challenge. Clinical changes during the protocol were scored. Colons were segmented into distal and proximal parts for histological and biochemical assessment...
November 27, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/30466957/-subcutaneous-administration-of-trastuzumab-at-home-feedback-of-patients-treated-in-2016-by-sant%C3%A3-service
#3
Christine Pailler, Thierry Chapot, Souad Softa, Nicolas Gandrille, Deborah Ruiz, Sylvaine Mathieu, Suzette Delaloge
In 2013, the European Medicines Agency authorized a new pharmaceutical formulation of the trastuzumab for breast cancer treatment. The latter allows a sub-cutaneous injection that reduces significantly the injection time and permits an administration at home. This study aims to assess the experience of patients treated by trastuzumab subcutaneously at home in 2016, and the experience of the nurses who performed these injections. In 2017, a retrospective survey by phone calls could gather the impressions from 84 patients on their treatment...
November 19, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/30430936/immunodominant-ige-epitopes-of-der-p-5-allergen
#4
Sadjia Lahiani, Marie-Eve Dumez, Ahlem Bouaziz, Kamel Djenouhat, Souad Khemili, Idir Bitam, Dimitri Gilis, Moreno Galleni
BACKGROUND: Der p 5 is an important allergen of Dermatophagoides pteronyssinus that plays a key role in allergic airway diseases. Its three dimensional structure (PDB 3MQ1) consists of three anti-parallel α-helices arranged in a helical bundle. Aggregation of Der p5 can modulate its allergenicity. This study aimed to identify the key residues of IgE binding epitopes of Der p 5. METHODS: IgE binding epitopes of Der p 5 were characterized as follow. An in silico prediction of the epitope was performed with the help of SEPPA program...
November 14, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/30425641/appropriateness-of-doac-prescribing-before-and-during-hospital-admission-and-analysis-of-determinants-for-inappropriate-prescribing
#5
Souad Moudallel, Stephane Steurbaut, Pieter Cornu, Alain Dupont
Background and Objectives: Appropriate dosing of direct oral anticoagulants (DOACs) is required to avoid under- and overdosing that may precipitate strokes or thromboembolic events and bleedings, respectively. Our objective was to analyze the appropriateness of DOAC dosing according to the summaries of product characteristics (SmPC). Furthermore, determinants for inappropriate prescribing were investigated. Methodology: Retrospective cohort study of hospitalized patients aged ≥60 years with at least one DOAC intake during hospital stay...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30423708/the-first-one-pot-synthesis-of-undoped-and-eu-doped-%C3%AE-nayf4-nanocrystals-and-their-evaluation-as-efficient-dyes-for-nanomedicine
#6
Walid Mnasri, Lotfi Ben Tahar, Michel Boissière, Darine Abi Haidar, Souad Ammar
Polygonal-shaped about 75 nm sized and highly crystallized Eu3+ -doped β-NaYF4 particles were directly prepared under mild conditions using the polyol process. A set of operating parameters were optimized for such a purpose. A conventional heating under reflux for 30 min of a mixture of Y(III) and Eu(III) acetate, ammonium fluoride, sodium hydroxide and oleic acid (OA) dissolved in ethyleneglycol offered a pertinent material processing route if a large excess of NH4 F and an enough amount of OA were used...
January 1, 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30376611/non-peptidic-cell-penetrating-motifs-for-mitochondrion-specific-cargo-delivery
#7
Dehua Pei, George Appiah Kubi, Ziqing Qian, Souad Amiar, Ashweta Sahni, Robert V Stahelin
Mitochondrial dysfunction is linked to a variety of human illnesses, but selective delivery of therapeutics into the mitochondrion has been challenging. We report herein a family of amphipathic cell-penetrating motifs (CPMs) consisting of four guanidinium groups and one or two aromatic hydrophobic groups (e.g., naphthalene) assembled through a central scaffold (e.g., a benzene ring). The CPMs and CPM-cargo conjugates efficiently enter the interior of cultured mammalian cells and are specifically localized into the mitochondrial matrix, as revealed by high-resolution confocal microscopy...
October 30, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/30314250/the-genus-haplodrassus-chamberlin-1922-in-the-mediterranean-and-the-maghreb-in-particular-araneae-gnaphosidae
#8
Robert Bosmans, Ourida Kherbouche-Abrous, SouÂd Benhalima, Christophe HervÉ
The Haplodrassus species of the the Maghreb are revised. Six new species are described: H. dentifer Bosmans Abrous, sp. n. (♂♀, Algeria, Morocco, Tunisia, Spain), H. longivulva Bosmans Hervé, sp. n. (♂♀, Algeria, Morocco), H. lyndae Abrous Bosmans, sp. n. (♂♀, Algeria, Morocco, Spain), H. ovatus Bosmans Hervé, sp. n. (Tunisia, Algeria), H. securifer Bosmans Abrous, sp. n. (♂♀, Algeria, Morocco, Tunisia, Portugal, Spain, France, Italy, Belgium) and H. triangularis Bosmans, sp. n. (♂♀, Morocco, Tunisia)...
July 30, 2018: Zootaxa
https://www.readbyqxmd.com/read/30304701/squalene-peg-pyropheophorbide-a-nanoconstructs-for-tumor-theranostics
#9
Souad Adriouach, Vassily Vorobiev, Gregor Trefalt, Eric Allémann, Norbert Lange, Andrej Babič
Novel nanoscale drug delivery biomaterials are of great importance for the diagnosis and treatment of different cancers. We have developed a new pegylated squalene (SQ-PEG) derivative with self-assembly properties. Supramolecular assembly with a lipophilic photosensitizer pyropheophorbide-a (Ppa) by nanoprecipitation gave nanoconstructs SQ-PEG:Ppa with an average size of 200 nm in diameter and a drug loading of 18% (w/w). The composite material demonstrates nanoscale optical properties by tight packing of Ppa within Sq-PEG:Ppa resulting in 99...
October 7, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/30298622/high-prevalence-of-congenital-deafness-on-reunion-island-is-due-to-a-founder-variant-of-lhfpl5
#10
Justine Lerat, Crystel Bonnet, François Cartault, Natalie Loundon, Marie-Line Jacquemont, Françoise Darcel, Isabelle Rouillon, Kheira Mezouaghi, Agnes Guichet, Julie Litzler, Roselyne Gesny, Souad Gherbi, Ines Ben Aissa, Fabienne Saint James Digeon, Eréa-Nöel Garabedian, Jean-Paul Bonnefont, Emmanuelle Genin, Françoise Denoyelle, Laurence Jonard, Sandrine Marlin
Reunion Island is a French oversea department in the Indian Ocean with 1.6/1000, an estimated prevalence of deafness that is almost double as compared to the mainland France. Twelve children having isolated bilateral prelingual profound deafness along with motor delay attributed to vestibular areflexia were enrolled. Their mean walking age was 19 months. Electroretinography and temporal bone CT-scans were normal in all cases. A novel homozygous frameshift lipoma HMGIC fusion partner-like 5 (LHFPL5) variant c...
October 8, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/30279148/myrtenal-induced-v-atpase-inhibition-a-toxicity-mechanism-behind-tumor-cell-death-and-suppressed-migration-and-invasion-in-melanoma
#11
Brunna Xavier Martins, Raul Ferraz Arruda, Gildeíde Aparecida Costa, Hassan Jerdy, Sávio Bastos de Souza, Julianna Maria Santos, William Rodrigues de Freitas, Milton Masahiko Kanashiro, Eulógio Carlos Queiroz de Carvalho, Nadir Francisca Sant'Anna, Fernanda Antunes, Raul Martinez-Zaguilan, Sennoune Souad, Anna Lvovna Okorokova-Façanha, Arnoldo Rocha Façanha
BACKGROUND: Metastatic tumor cells have acidic extracellular pH and differential electrochemical H+ gradients generated across their cell membranes by V-type H+ -ATPases. This study shows that inhibition of the V-ATPases by the plant-derived monoterpene Myrtenal results in tumor cell death and decreased metastatic dissemination in mice. METHODS: The Myrtenal anticancer toxicity was evaluated in vitro using murine (B16F0 and B16F10) and human (SkMel-5) melanoma cell lines, and in in vivo mouse metastatic dissemination model...
September 11, 2018: Biochimica et biophysica acta. General subjects
https://www.readbyqxmd.com/read/30262976/a-specific-qsar-model-for-proteasome-inhibitors-from-oleaeuropaea-and-ficuscarica
#12
Lahmadi Ayoub, El-Aliani Aissam, Kasmi Yassine, Elantri Said, El Mzibri Mohammed, Aboudkhil Souad
Oleaeuropaea and Ficuscarica are widely used in traditional medicine for the treatment of cancer. Therefore, it is of interest to develop a QSAR model for screening proteasome inhibitors from plant source. Hence, a QSAR model was developed using multiple linear regressions; partial least squares regression and principal component regression methods. Results of QSAR modeling and docking demonstrate that compounds derived from both plants have great potentiality to be proteasome inhibitors. The developed QSAR model highlights a strong structure-effect relationship...
2018: Bioinformation
https://www.readbyqxmd.com/read/30235305/in-silico-analysis-of-the-mus-musculus-uterine-gene-expression-landscape-during-pregnancy-identifies-putative-upstream-regulators-for-labour
#13
Febilla Fernando, Souad Boussata, Aldo Jongejan, Joris A van der Post, Gijs Afink, Carrie Ris-Stalpers
BACKGROUND: The molecular pathways involved in the transition from uterine quiescence to overt labour are mapped and form the currently established pharmacological targets for both the induction and inhibition of human labour. However, both spontaneous premature labour and functional dystocia occur and are difficult to treat adequately. The identification of upstream regulators involved in the onset and orchestration of labour pathways is essential to develop additional therapies that will contribute to the regulation of the timing of birth...
2018: PloS One
https://www.readbyqxmd.com/read/30233270/relationship-between-poor-quality-sleep-excessive-daytime-sleepiness-and-low-academic-performance-in-medical-students
#14
Abdelkader Jalil El Hangouche, Asmaa Jniene, Souad Aboudrar, Leila Errguig, Hanan Rkain, Mohammed Cherti, Taoufiq Dakka
Purpose: Poor quality of sleep and excessive daytime sleepiness affect cognitive ability and have a negative impact on the academic performance of medical students. This study aims to determine the prevalence of excessive daytime sleepiness, sleep quality and psychological distress as well as assess their association with low academic performance in this population. Participants and methods: A cross-sectional study was conducted among 457 medical students from the Faculty of Medicine and Pharmacy of Rabat, Morocco, who completed the Pittsburgh Sleep Quality Index (PSQI) questionnaire and the Epworth Sleepiness Scale to determine the quality of sleep and excessive daytime sleepiness, respectively...
2018: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/30230051/the-house-dust-mite-allergen-der-p-5-binds-lipid-ligands-and-stimulates-airway-epithelial-cells-through-a-tlr2-dependent-pathway
#15
Pinya Pulsawat, Tewarit Soongrung, Pattraporn Satitsuksanoa, Maxime Le Mignon, Souad Khemili, Dimitri Gilis, Emmanuel Nony, Malcolm W Kennedy, Alain Jacquet
BACKGROUND: Protein crystallographic studies suggest that the house dust mite (HDM) allergen Der p 5 potentially interacts with hydrophobic ligands. Der p 5, in association with its ligand(s), might therefore trigger innate immune signalling pathways in the airway epithelium and influence the initiation of the HDM-allergic response. OBJECTIVE: We investigated the lipid binding propensities of recombinant (r)Der p 5 and characterized the signalling pathways triggered by the allergen in airway epithelial cells...
September 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30228983/effect-of-ionizing-radiation-on-the-microbiological-safety-and-phytochemical-properties-of-cooked-malva-sylvestris-l
#16
Issam Ben Salem, Souad Ouesleti, Mohamed Amine Khammassi, Abdennacer Boulila, Yassine Mabrouk
Nowadays, recent studies have demonstrated that plant-derived foods were characterized by their richness in bioactive phytochemicals and their consumption has a protective effect for human health. The effects of ionizing radiation on phytochemical properties of cooked Malva sylvestris L. (Mallow) were investigated. Irradiation increased significantly (P<0.05) the total polyphenols and flavonoids content of cooked Mallow. Irradiation at 2 and 4 kGy doses resulted in a significant increase in the DPPH and ABTS radical-scavenging ability of cooked Mallow extracts...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30223595/removal-properties-of-anionic-dye-eosin-by-cetyltrimethylammonium-organo-clays-the-effect-of-counter-ions-and-regeneration-studies
#17
Fethi Kooli, Yan Liu, Mostafa Abboudi, Souad Rakass, Hicham Oudghiri Hassani, Sheikh Muhammad Ibrahim, Rawan Al-Faze
The organo-clays (OCs) were prepared by a cation exchange reaction between surfactant (cetyltrimethylammonium, C16TMA) from different counterions (Bromide, Chloride, and Hydroxide). The effect of the counterions was investigated on the physico-chemical properties of the prepared organo-clays. The highest uptake of organic cations (1.60 mmol/g) was achieved using cetyl trimethylammonium bromide solution and the lowest value (0.93 mmol/g) was obtained after modification with cetyl trimethylammonium hydroxide solution starting from the same initial ratio of mmol/g of clay greater than 2...
September 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30213282/insecticidal-effects-of-the-olea-europaea-subsp-laperrinei-extracts-on-the-flour-pyralid-ephestia-kuehniella
#18
Souad Lahcene, Faiza Taibi, Nadjet Mestar, Samira Ali Ahmed, Mahieddine Boumendjel, Saida Ouafi, Karim Houali
In the present study, the aerial parts of the Laperrine olive (Olea europaea subsp. Laperrinei) are subjected to acid extraction and the chemical composition of the extracts is determined by HPLC-DAD. The main compounds found in all of extracts are: hydroxytyrosol (30.45%), tyrosol (0.69%), oleuropein (32.76%), ferrulic acid (17.77%), quercetin (31.57%) and hesperetin (6.90%).The extracts obtained from the leafy stems of Laperrine olive tree are tested on the moth Ephestia kuehniella flour. Their administration by inhalation of newly exuviated chrysalises extends the duration of nymphalid development and disturbs the exuviated adults reproduction, by reducing the period in which the eggs are being laid...
August 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/30177933/the-nrf2-antioxidant-response-element-signaling-pathway-controls-fibrosis-and-autoimmunity-in-scleroderma
#19
Niloufar Kavian, Souad Mehlal, Mohamed Jeljeli, Nathaniel Edward Bennett Saidu, Carole Nicco, Olivier Cerles, Sandrine Chouzenoux, Anne Cauvet, Claire Camus, Mehdi Ait-Djoudi, Christiane Chéreau, Saadia Kerdine-Römer, Yannick Allanore, Frederic Batteux
Systemic sclerosis (SSc) is an autoimmune disease with fibrosis of the skin and internal organs and vascular alterations. Dysregulations in the oxidant/antioxidant balance are known to be a major factor in the pathogenesis of the disease. Indeed, reactive oxygen species (ROS) trigger neoepitopes leading to a breach of immune tolerance and autoimmune responses, activate fibroblasts to proliferate and to produce excess of type I collagen. ROS also alter endothelial cells leading to vascular dysfunction. Glutathione (GSH) is the most potent antioxidant system in eukaryotic cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30170019/new-growth-media-for-oral-bacteria
#20
Bénédicte Martin, Kanchana Chathoth, Souad Ouali, Vincent Meuric, Martine Bonnaure-Mallet, Christine Baysse
New growth media have been designed for the iron-controlled co-cultures of three oral bacteria. These media share a common core composition enabling the switch from mono- to co-cultures, and efficiently promote both planktonic and biofilm cultures of Porphyromonas gingivalis, Treponema denticola and Streptococcus gordonii.
October 2018: Journal of Microbiological Methods
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