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https://www.readbyqxmd.com/read/30314250/the-genus-haplodrassus-chamberlin-1922-in-the-mediterranean-and-the-maghreb-in-particular-araneae-gnaphosidae
#1
Robert Bosmans, Ourida Kherbouche-Abrous, SouÂd Benhalima, Christophe HervÉ
The Haplodrassus species of the the Maghreb are revised. Six new species are described: H. dentifer Bosmans Abrous, sp. n. (♂♀, Algeria, Morocco, Tunisia, Spain), H. longivulva Bosmans Hervé, sp. n. (♂♀, Algeria, Morocco), H. lyndae Abrous Bosmans, sp. n. (♂♀, Algeria, Morocco, Spain), H. ovatus Bosmans Hervé, sp. n. (Tunisia, Algeria), H. securifer Bosmans Abrous, sp. n. (♂♀, Algeria, Morocco, Tunisia, Portugal, Spain, France, Italy, Belgium) and H. triangularis Bosmans, sp. n. (♂♀, Morocco, Tunisia)...
July 30, 2018: Zootaxa
https://www.readbyqxmd.com/read/30304701/squalene-peg-pyropheophorbide-a-nanoconstructs-for-tumor-theranostics
#2
Souad Adriouach, Vassily Vorobiev, Gregor Trefalt, Eric Allémann, Norbert Lange, Andrej Babič
Novel nanoscale drug delivery biomaterials are of great importance for the diagnosis and treatment of different cancers. We have developed a new pegylated squalene (SQ-PEG) derivative with self-assembly properties. Supramolecular assembly with a lipophilic photosensitizer pyropheophorbide-a (Ppa) by nanoprecipitation gave nanoconstructs SQ-PEG:Ppa with an average size of 200nm in diameter and a drug loading of 18% (w/w). The composite material demonstrates nanoscale optical properties by tight packing of Ppa within Sq-PEG:Ppa resulting in 99...
October 7, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/30298622/high-prevalence-of-congenital-deafness-on-reunion-island-is-due-to-a-founder-variant-of-lhfpl5
#3
Justine Lerat, Crystel Bonnet, François Cartault, Natalie Loundon, Marie-Line Jacquemont, Françoise Darcel, Isabelle Rouillon, Kheira Mezouaghi, Agnes Guichet, Julie Litzler, Roselyne Gesny, Souad Gherbi, Ines B E N Aissa, Fabienne S A I N T J A M E S Digeon, Eréa-Nöel Garabedian, Jean-Paul Bonnefont, Emmanuelle Genin, Françoise Denoyelle, Laurence Jonard, Sandrine Marlin
Reunion Island is a French oversea department in the Indian Ocean with 1.6/1000, an estimated prevalence of deafness that is almost double as compared to the mainland France. Twelve children having isolated bilateral prelingual profound deafness along with motor delay attributed to vestibular areflexia were enrolled. Their mean walking age was 19 months. Electroretinography and temporal bone CT-scans were normal in all cases. A novel homozygous frameshift LHFPL5 variant c.185delT p.(Phe62Serfs*23) was identified using Whole Exome Sequencing (WES)...
October 8, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/30279148/myrtenal-induced-v-atpase-inhibition-a-toxicity-mechanism-behind-tumor-cell-death-and-suppressed-migration-and-invasion-in-melanoma
#4
Brunna Xavier Martins, Raul Ferraz Arruda, Gildeíde Aparecida Costa, Hassan Jerdy, Sávio Bastos de Souza, Julianna Maria Santos, William Rodrigues de Freitas, Milton Masahiko Kanashiro, Eulógio Carlos Queiroz de Carvalho, Nadir Francisca Sant'Anna, Fernanda Antunes, Raul Martinez-Zaguilan, Sennoune Souad, Anna Lvovna Okorokova-Façanha, Arnoldo Rocha Façanha
BACKGROUND: Metastatic tumor cells have acidic extracellular pH and differential electrochemical H+ gradients generated across their cell membranes by V-type H+ -ATPases. This study shows that inhibition of the V-ATPases by the plant-derived monoterpene Myrtenal results in tumor cell death and decreased metastatic dissemination in mice. METHODS: The Myrtenal anticancer toxicity was evaluated in vitro using murine (B16F0 and B16F10) and human (SkMel-5) melanoma cell lines, and in in vivo mouse metastatic dissemination model...
September 11, 2018: Biochimica et biophysica acta. General subjects
https://www.readbyqxmd.com/read/30262976/a-specific-qsar-model-for-proteasome-inhibitors-from-oleaeuropaea-and-ficuscarica
#5
Lahmadi Ayoub, El-Aliani Aissam, Kasmi Yassine, Elantri Said, El Mzibri Mohammed, Aboudkhil Souad
Oleaeuropaea and Ficuscarica are widely used in traditional medicine for the treatment of cancer. Therefore, it is of interest to develop a QSAR model for screening proteasome inhibitors from plant source. Hence, a QSAR model was developed using multiple linear regressions; partial least squares regression and principal component regression methods. Results of QSAR modeling and docking demonstrate that compounds derived from both plants have great potentiality to be proteasome inhibitors. The developed QSAR model highlights a strong structure-effect relationship...
2018: Bioinformation
https://www.readbyqxmd.com/read/30235305/in-silico-analysis-of-the-mus-musculus-uterine-gene-expression-landscape-during-pregnancy-identifies-putative-upstream-regulators-for-labour
#6
Febilla Fernando, Souad Boussata, Aldo Jongejan, Joris A van der Post, Gijs Afink, Carrie Ris-Stalpers
BACKGROUND: The molecular pathways involved in the transition from uterine quiescence to overt labour are mapped and form the currently established pharmacological targets for both the induction and inhibition of human labour. However, both spontaneous premature labour and functional dystocia occur and are difficult to treat adequately. The identification of upstream regulators involved in the onset and orchestration of labour pathways is essential to develop additional therapies that will contribute to the regulation of the timing of birth...
2018: PloS One
https://www.readbyqxmd.com/read/30233270/relationship-between-poor-quality-sleep-excessive-daytime-sleepiness-and-low-academic-performance-in-medical-students
#7
Abdelkader Jalil El Hangouche, Asmaa Jniene, Souad Aboudrar, Leila Errguig, Hanan Rkain, Mohammed Cherti, Taoufiq Dakka
Purpose: Poor quality of sleep and excessive daytime sleepiness affect cognitive ability and have a negative impact on the academic performance of medical students. This study aims to determine the prevalence of excessive daytime sleepiness, sleep quality and psychological distress as well as assess their association with low academic performance in this population. Participants and methods: A cross-sectional study was conducted among 457 medical students from the Faculty of Medicine and Pharmacy of Rabat, Morocco, who completed the Pittsburgh Sleep Quality Index (PSQI) questionnaire and the Epworth Sleepiness Scale to determine the quality of sleep and excessive daytime sleepiness, respectively...
2018: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/30230051/the-house-dust-mite-allergen-der-p-5-binds-lipid-ligands-and-stimulates-airway-epithelial-cells-through-a-tlr2-dependent-pathway
#8
Pinya Pulsawat, Tewarit Songrung, Pattraporn Satitsuksanoa, Maxime Le Mignon, Souad Khemili, Dimitri Gilis, Emmanuel Nony, Malcolm W Kennedy, Alain Jacquet
BACKGROUND: Protein crystallographic studies suggest that the house dust mite (HDM) allergen Der p 5 potentially interacts with hydrophobic ligands. Der p 5, in association with its ligand(s), might therefore trigger innate immune signaling pathways in the airway epithelium and influence the initiation of the HDM-allergic response. OBJECTIVE: We investigated the lipid-binding propensities of recombinant (r)Der p 5 and characterized the signaling pathways triggered by the allergen in airway epithelial cells...
September 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30228983/effect-of-ionizing-radiation-on-the-microbiological-safety-and-phytochemical-properties-of-cooked-malva-sylvestris-l
#9
Issam Ben Salem, Souad Ouesleti, Mohamed Amine Khammassi, Abdennacer Boulila, Yassine Mabrouk
Nowadays, recent studies have demonstrated that plant-derived foods were characterized by their richness in bioactive phytochemicals and their consumption has a protective effect for human health. The effects of ionizing radiation on phytochemical properties of cooked Malva sylvestris L. (Mallow) were investigated. Irradiation increased significantly (P<0.05) the total polyphenols and flavonoids content of cooked Mallow. Irradiation at 2 and 4 kGy doses resulted in a significant increase in the DPPH and ABTS radical-scavenging ability of cooked Mallow extracts...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30223595/removal-properties-of-anionic-dye-eosin-by-cetyltrimethylammonium-organo-clays-the-effect-of-counter-ions-and-regeneration-studies
#10
Fethi Kooli, Yan Liu, Mostafa Abboudi, Souad Rakass, Hicham Oudghiri Hassani, Sheikh Muhammad Ibrahim, Rawan Al-Faze
The organo-clays (OCs) were prepared by a cation exchange reaction between surfactant (cetyltrimethylammonium, C16TMA) from different counterions (Bromide, Chloride, and Hydroxide). The effect of the counterions was investigated on the physico-chemical properties of the prepared organo-clays. The highest uptake of organic cations (1.60 mmol/g) was achieved using cetyl trimethylammonium bromide solution and the lowest value (0.93 mmol/g) was obtained after modification with cetyl trimethylammonium hydroxide solution starting from the same initial ratio of mmol/g of clay greater than 2...
September 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30213282/insecticidal-effects-of-the-olea-europaea-subsp-laperrinei-extracts-on-the-flour-pyralid-ephestia-kuehniella
#11
Souad Lahcene, Faiza Taibi, Nadjet Mestar, Samira Ali Ahmed, Mahieddine Boumendjel, Saida Ouafi, Karim Houali
In the present study, the aerial parts of the Laperrine olive (Olea europaea subsp. Laperrinei) are subjected to acid extraction and the chemical composition of the extracts is determined by HPLC-DAD. The main compounds found in all of extracts are: hydroxytyrosol (30.45%), tyrosol (0.69%), oleuropein (32.76%), ferrulic acid (17.77%), quercetin (31.57%) and hesperetin (6.90%).The extracts obtained from the leafy stems of Laperrine olive tree are tested on the moth Ephestia kuehniella flour. Their administration by inhalation of newly exuviated chrysalises extends the duration of nymphalid development and disturbs the exuviated adults reproduction, by reducing the period in which the eggs are being laid...
August 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/30177933/the-nrf2-antioxidant-response-element-signaling-pathway-controls-fibrosis-and-autoimmunity-in-scleroderma
#12
Niloufar Kavian, Souad Mehlal, Mohamed Jeljeli, Nathaniel Edward Bennett Saidu, Carole Nicco, Olivier Cerles, Sandrine Chouzenoux, Anne Cauvet, Claire Camus, Mehdi Ait-Djoudi, Christiane Chéreau, Saadia Kerdine-Römer, Yannick Allanore, Frederic Batteux
Systemic sclerosis (SSc) is an autoimmune disease with fibrosis of the skin and internal organs and vascular alterations. Dysregulations in the oxidant/antioxidant balance are known to be a major factor in the pathogenesis of the disease. Indeed, reactive oxygen species (ROS) trigger neoepitopes leading to a breach of immune tolerance and autoimmune responses, activate fibroblasts to proliferate and to produce excess of type I collagen. ROS also alter endothelial cells leading to vascular dysfunction. Glutathione (GSH) is the most potent antioxidant system in eukaryotic cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30170019/new-growth-media-for-oral-bacteria
#13
Bénédicte Martin, Kanchana Chathoth, Souad Ouali, Vincent Meuric, Martine Bonnaure-Mallet, Christine Baysse
New growth media have been designed for the iron-controlled co-cultures of three oral bacteria. These media share a common core composition enabling the switch from mono- to co-cultures, and efficiently promote both planktonic and biofilm cultures of Porphyromonas gingivalis, Treponema denticola and Streptococcus gordonii.
August 28, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/30159858/fasciae-of-the-musculoskeletal-system-normal-anatomy-and-mr-patterns-of-involvement-in-autoimmune-diseases
#14
REVIEW
Thomas Kirchgesner, Xavier Demondion, Maria Stoenoiu, Patrick Durez, Adrien Nzeusseu Toukap, Frédéric Houssiau, Christine Galant, Souad Acid, Frédéric Lecouvet, Jacques Malghem, Bruno Vande Berg
The fascial system is a three-dimensional continuum of connective tissues present everywhere throughout the body, from the head to the toes and from the skin to the bone. The current article aims to review the normal anatomy of the fasciae of the musculoskeletal system with macroscopic and microscopic correlations and to describe their appearance at MRI in normal subjects and in patients with autoimmune diseases of the musculoskeletal system. KEY POINTS: • The fascial system is a three-dimensional continuum of connective tissues...
August 29, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/30133707/sm-p80-based-schistosomiasis-vaccine-double-blind-preclinical-trial-in-baboons-demonstrates-comprehensive-prophylactic-and-parasite-transmission-blocking-efficacy
#15
Weidong Zhang, Adebayo J Molehin, Juan U Rojo, Justin Sudduth, Pramodh K Ganapathy, Eunjee Kim, Arif J Siddiqui, Jasmin Freeborn, Souad R Sennoune, Jordan May, Samra Lazarus, Catherine Nguyen, Whitni K Redman, Gul Ahmad, Workineh Torben, Souvik Karmakar, Loc Le, Kameswara R Kottapalli, Pratibha Kottapalli, Roman F Wolf, James F Papin, David Carey, Sean A Gray, Jenn D Bergthold, Raymond T Damian, Bryan T Mayer, Florian Marks, Steven G Reed, Darrick Carter, Afzal A Siddiqui
Schistosomiasis is of public health importance to an estimated one billion people in 79 countries. A vaccine is urgently needed. Here, we report the results of four independent, double-blind studies of an Sm-p80-based vaccine in baboons. The vaccine exhibited potent prophylactic efficacy against transmission of Schistosoma mansoni infection and was associated with significantly less egg-induced pathology, compared with unvaccinated control animals. Specifically, the vaccine resulted in a 93.45% reduction of pathology-producing female worms and significantly resolved the major clinical manifestations of hepatic/intestinal schistosomiasis by reducing the tissue egg-load by 89...
August 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/30123412/x-linked-vitamin-d-resistant-rickets-12-years-of-follow-up
#16
Ahmed Anas Guerboub, Souad Moussaoui, Jad Issouani, Yassine Errahali, Ghizlaine Belmejdoub
Rickets are abnormalities of mineralization that can lead to bone fractures and deformities. Vitamin-resistant rickets is defined as any rickets not prevented by regular, early and prolonged administration of vitamin D and not cured by a sufficient total dose. The aim of our work is to describe the clinical, paraclinical and therapeutic aspects of X-linked hypophosphatemic rickets (XLHR), which is the most common cause of hereditary rickets and on the other hand to highlight the interest not only of the early care but also the regular long-term monitoring of these children...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/30108543/deep-brain-stimulation-in-moroccan-patients-with-parkinson-s-disease-the-experience-of-neurology-department-of-rabat
#17
Mounia Rahmani, Maria Benabdeljlil, Fouad Bellakhdar, Mustapha El Alaoui Faris, Mohamed Jiddane, Khalil El Bayad, Fatima Boutbib, Rachid Razine, Rachid Gana, Moulay R El Hassani, Nizar El Fatemi, Meryem Fikri, Siham Sanhaji, Hennou Tassine, Imane El Alaoui Balrhiti, Souad El Hadri, Najwa Ech-Cherif Kettani, Najia El Abbadi, Mourad Amor, Abdelmjid Moussaoui, Afifa Semlali, Saadia Aidi, El Hachmia Ait Benhaddou, Ali Benomar, Ahmed Bouhouche, Mohamed Yahyaoui, Abdeslam El Khamlichi, Abdessamad El Ouahabi, Rachid El Maaqili, Houyam Tibar, Yasser Arkha, Adyl Melhaoui, Abdelhamid Benazzouz, Wafa Regragui
Introduction: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is known as a therapy of choice of advanced Parkinson's disease. The present study aimed to assess the beneficial and side effects of STN DBS in Moroccan Parkinsonian patients. Material and Methods: Thirty five patients underwent bilateral STN DBS from 2008 to 2016 in the Rabat University Hospital. Patients were assessed preoperatively and followed up for 6 to 12 months using the Unified Parkinson's Disease Rating Scale in four conditions (stimulation OFF and ON and medication OFF and ON), the levodopa-equivalent daily dose (LEDD), dyskinesia and fluctuation scores and PDQ39 scale for quality of life (QOL)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30101717/novel-tetrahydrobenzo-b-thiophene-compounds-exhibit-anticancer-activity-through-enhancing-apoptosis-and-inhibiting-tyrosine-kinase
#18
Souad A El-Metwally, Ali K Khalil, Abeer M El-Naggar, Wael M El-Sayed
ackground: Developing new chemotherapeutic agents with molecular targets, larger margin of safety against normal cells and low cost is the target many scientists try to achieve. OBJECTIVE: The present study was undertaken to investigate the anticancer activity of a novel series of thiophene compounds and the molecular mechanisms associated. METHODS: A series of novel heterocyclic compounds including pyrimidine derivatives (2, 3, 4, 5 8, 11, 12, 13, 14, and 15), thiophene derivatives (6, 7, and 10) and oxoisothiazolidine derivative (9) was synthesized from 4,5,6,7-tetrahydrobenzo[b] thiophene (1)...
August 13, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/30081600/modified-nigella-sativa-seeds-as-a-novel-efficient-natural-adsorbent-for-removal-of-methylene-blue-dye
#19
Souad Rakass, Ahmed Mohmoud, Hicham Oudghiri Hassani, Mostafa Abboudi, Fethi Kooli, Fahd Al Wadaani
The aim of this work was to investigate the use of modified nigella sativa seeds (MNS) for removing of methylene blue (MB) dye from aqueous solution. The nigella sativa (NS) seeds have been pre-treated at different temperatures and periods of time. The maximum adsorption of MB was achieved using NS sample washed with distilled water pre-heated at 65 °C for one hour, then ground to 250 µm particle size (MNS-4). Different parameters were modified to optimize the removal process of MB using MNS-4, such as contact times, temperatures, initial dye concentrations, adsorbent doses, and pH of the solution...
August 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30037049/management-of-leishmaniases-in-the-era-of-climate-change-in-morocco
#20
Kahime Kholoud, Sereno Denis, Bounoua Lahouari, Moulay Abdelmonaim El Hidan, Bouhout Souad
The proliferation of vector-borne diseases are predicted to increase in a changing climate and Leishmaniases, as a vector-borne diseases, are re-emerging diseases in several regions of the world. In Morocco, during the last decade, a sharp increase in cutaneous leishmaniases cases has been reported. Nevertheless, in Morocco, leishmaniases are a major public health problem, and little interest was given to climate change impacts on the distribution and spread of these diseases. As insect-borne diseases, the incidence and distribution of leishmaniases are influenced by environmental changes, but also by several socio-economic and cultural factors...
July 20, 2018: International Journal of Environmental Research and Public Health
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