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Basal metabolic rate

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https://www.readbyqxmd.com/read/29343514/trpm2-channel-mediated-regulation-of-autophagy-maintains-mitochondrial-function-and-promotes-gastric-cancer-cell-survival-via-the-jnk-signaling-pathway
#1
Shekoufeh Almasi, Barry E Kennedy, Mariam El Aghil, Andra M Sterea, Shashi Gujar, Santiago Partida-Sánchez, Yassine El Hiani
A lack of effective treatment is one of the main factors contributing to gastric cancer-related death. Discovering effective targets and understanding their underlying anticancer mechanism is key to achieving the best response to treatment and to limiting side effects. Although recent studies have shown that the cation channel transient receptor potential melastatin-2 (TRPM2) is crucial for cancer cell survival, the exact mechanism remains unclear, limiting its therapeutic potential. Here, using molecular and functional assays, we investigated the role of TRPM2 in survival of gastric cancer cells...
January 17, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29341311/decreased-thermal-sweating-of-central-sudomotor-mechanism-in-african-and-korean-men
#2
Jeong Beom Lee, Jeong Ho Kim
OBJECTIVE: Tropical natives sweat less and preserve more body fluid than temperate natives, tolerating heat stress. However, the mechanisms involved in such sweating reduction have not been fully elucidated. We examined the sudomotor responses of men of African (n = 36) and Korean (n = 41) ancestry during hot water (43 °C) leg immersion (central sudomotor response). Correlations between mean body temperature, basal metabolic rate (BMR), and sweat rate were also examined. METHODS: All procedures were done in an automated climate chamber...
January 17, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29337247/effects-of-dietary-administration-of-fenugreek-seeds-on-metabolic-parameters-and-immune-status-of-gilthead-seabream-sparus-aurata-l
#3
F A Guardiola, A Bahi, M A Esteban
Medical plants could be used as a prophylactic method in aquaculture because they are considered safe and so very promising alternatives to the use of chemicals. The aim of the present work was to examine the effects of dietary fenugreek (Trigonella foenum graecum) seeds administered for 8 weeks on the metabolic and immune status of gilthead seabream (Sparus aurata L.). Four experimental groups were designated: one receiving a basal diet (control) and three fed powdered fenugreek seeds incorporated in the fish feed at 1%, 5% and 10%...
January 11, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29326115/understanding-variation-in-metabolic-rate
#4
REVIEW
Amanda K Pettersen, Dustin J Marshall, Craig R White
Metabolic rate reflects an organism's capacity for growth, maintenance and reproduction, and is likely to be a target of selection. Physiologists have long sought to understand the causes and consequences of within-individual to among-species variation in metabolic rates - how metabolic rates relate to performance and how they should evolve. Traditionally, this has been viewed from a mechanistic perspective, relying primarily on hypothesis-driven approaches. A more agnostic, but ultimately more powerful tool for understanding the dynamics of phenotypic variation is through use of the breeder's equation, because variation in metabolic rate is likely to be a consequence of underlying microevolutionary processes...
January 11, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29322349/development-of-a-chemically-defined-platform-fed-batch-culture-media-for-monoclonal-antibody-producing-cho-cell-lines-with-optimized-choline-content
#5
Shinobu Kuwae, Ichiko Miyakawa, Tomohiro Doi
A chemically defined platform basal medium and feed media were developed using a single Chinese hamster ovary (CHO) cell line that produces a monoclonal antibody (mAb). Cell line A, which showed a peak viable cell density of 5.9 × 106 cells/mL and a final mAb titer of 0.5 g/L in batch culture, was selected for the platform media development. Stoichiometrically balanced feed media were developed using glucose as an indicator of cell metabolism to determine the feed rates of all other nutrients. A fed-batch culture of cell line A using the platform fed-batch medium yielded a 6...
January 11, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29315167/predicting-basal-metabolic-rate-in-men-with-motor-complete-spinal-cord-injury
#6
Tom E Nightingale, Ashraf S Gorgey
PURPOSE: To assess the accuracy of existing basal metabolic rate (BMR) prediction equations in men with chronic (>1 year) spinal cord injury (SCI). The primary aim is to develop new SCI population-specific BMR prediction models, based on anthropometric, body composition and/or demographic variables that are strongly associated with BMR. METHODS: Thirty men with chronic SCI (Paraplegic; n = 21, Tetraplegic; n = 9), aged 35 ± 11 years (mean ± SD) participated in this cross-sectional study...
January 8, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29313566/factors-influencing-high-quality-chest-compressions-during-cardiopulmonary-resuscitation-scenario-according-to-2015-american-heart-association-guidelines
#7
Halla Kaminska, Wojciech Wieczorek, Pawel Matysiuk, Lukasz Czyzewski, Jerzy Robert Ladny, Jacek Smereka, Krzysztof J Filipiak, Lukasz Szarpak
BACKGROUND AND AIM: Recent American Heart Association Guidelines from 2010 and 2015 year stressed the importance of high quality chest compression and define standards for compression rate, depth, recoil and maximal acceptable time for interruptions. High - quality cardiopulmonary resuscitation (CPR) is the "cornerstone" of a system of care that can optimize outcomes beyond return of spontaneous circulation Methods: 100 medical students were enrolled to the study. Study participants after Basic Life Support Course according to American Heart Association 2015 guidelines performed 2-min cardiopulmonary resuscitation on Resusci Anne® QCPR Manikin...
January 9, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29313445/body-composition-metabolism-sleep-psychological-and-eating-patterns-of-overtraining-syndrome-results-of-the-eros-study-eros-profile
#8
Flavio A Cadegiani, Claudio E Kater
Overtraining syndrome (OTS) is caused by an imbalance between training, nutrition and resting, and leads to decreased performance and fatigue; however, the precise underlying triggers of OTS remain unclear. This study investigated the body composition, metabolism, eating, sleeping patterns and mood states among participants with OTS. Selected participants were divided into OTS-affected athletes (OTS, n = 14), healthy athletes (ATL, n = 25), and healthy non-physically active controls (NCS, n = 12). Compared to ATL, OTS showed decreased sleep quality (p = 0...
January 9, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29301981/controlling-of-n-alkylpolyamine-analogue-metabolism-by-selective-deuteration
#9
Sebahat Ucal, Merja R Häkkinen, Aino-Liisa Alanne, Leena Alhonen, Jouko Vepsäläinen, Tuomo A Keinänen, Mervi T Hyvönen
Replacing protium with deuterium is an efficient method to modulate drug metabolism. N -alkylated polyamine analogues are polyamine antimetabolites with proven anticancer efficacy. We have characterized earlier the preferred metabolic routes of N1,N12 -diethylspermine (DESpm), N1 -benzyl- N12 -ethylspermine (BnEtSpm) and N1,N12 -dibenzylspermine (DBSpm) by human recombinant spermine oxidase (SMOX) and acetylpolyamine oxidase (APAO). Here we studied the above analogues, their variably deuterated counterparts and their metabolites as substrates and inhibitors of APAO, SMOX, semicarbazide-sensitive amine oxidase (SSAO), diamine oxidase (DAO) and monoamine oxidases...
January 4, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29301686/is-there-an-effect-of-environmental-temperature-on-the-response-to-an-antigen-and-the-metabolic-rate-in-pups-of-the-rodent-octodon-degus
#10
Natalia Ramirez-Otarola, Janyra Espinoza, Alexis M Kalergis, Pablo Sabat
Environmental temperature is a variable that influences all aspects of organisms, from physiological, e.g. immune function, and morphological traits to behavior. Recent studies have reported that environmental temperature modulates organisms' thermoregulatory capacity and immune response, suggesting that trade-offs must be made between thermoregulation and immune function. Despite this, studies that evaluate this trade-off in developing endotherms are scarce. The aim of this study was to evaluate the effects of environmental temperature experienced during development on the response to an antigen and its energetic costs in the precocial rodent Octodon degus...
January 2018: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29288524/insulin-deficiency-with-and-without-glucagon-a-comparative-study-between-total-pancreatectomy-and-type-1-diabetes
#11
Fumimaru Niwano, Yoshihisa Hiromine, Shinsuke Noso, Naru Babaya, Hiroyuki Ito, Sara Yasutake, Ippei Matsumoto, Yoshifumi Takeyama, Yumiko Kawabata, Hiroshi Ikegami
AIMS: Patients with total pancreatectomy and type 1 diabetes are similar in absolute insulin deficiency, but different in glucagon, providing unique opportunity to study the contribution of glucagon on glucose metabolism in insulin-dependent state. To investigate the contribution of glucagon to glucose homeostasis in complete insulin deficiency in vivo. METHODS: A total of 38 subjects with a complete lack of endogenous insulin (fasting C-peptide < 0.0066 nmol/L) and whose glycemic control was optimized with an insulin pump during hospitalization were retrospectively studied...
December 30, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29278661/structural-and-functional-responses-of-periphyton-and-macroinvertebrate-communities-to-ferric-fe-cu-and-zn-in-stream-mesocosms
#12
Pete Cadmus, Helena Guasch, Adam T Herdrich, Berta Bonet, Gemma Urrea, William H Clements
Two mesocosm experiments were conducted to examine effects of ferric iron (Fe) and mixtures of ferric Fe with aqueous metals (Cu, Zn) on stream benthic communities. Naturally colonized benthic communities were exposed to a gradient of ferric Fe (0, 0.4, 1.0, 2.5, 6.2 and 15.6 mg/L) that bracketed the current U.S. EPA water quality criterion value (1.0 mg/L). After 10 d to ferric Fe, total macroinvertebrate abundance, number of taxa and the abundance of all major macroinvertebrate groups (Ephemeroptera, Plecoptera, Trichoptera, and Diptera) were significantly reduced...
December 26, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29278510/regulation-of-basal-metabolic-rate-in-uncomplicated-pregnancy-and-in-gestational-diabetes-mellitus
#13
REVIEW
Eleftheria Taousani, Dimitra Savvaki, Efrosin Tsirou, Pavlos Poulakos, Gesthimani Mintziori, Menelaos Zafrakas, Dimitrios Vavilis, Dimitrios G Goulis
Basal metabolic rate (BMR) is one of the major components of total energy expenditure (TEE). It is affected by various factors, such as body weight, body composition, age, race/ethnicity, gender, biochemical parameters, physical activity, and health status. Gestational diabetes mellitus (GDM) is the most common metabolic disorder during pregnancy and it increases the risk for health complications, such as stillbirth, diabetes mellitus, and cardiovascular disease in later life. Both BMR and GDM have been linked with gestational weight gain (GWG), a fact suggesting a possible association between them...
July 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29274249/cell-wall-proteome-of-sugarcane-young-and-mature-leaves-and-stems
#14
Juliana G Fonseca, Maria J Calderan-Rodrigues, Fabrício E de Moraes, Thaís R Cataldi, Elisabeth Jamet, Carlos A Labate
By characterizing the cell wall proteomes of different sugarcane organs (leaves and stems) at two developmental stages (young vs mature/apical vs basal), it was possible to address unique characteristics in each of them. Four-month-old leaves showed a higher proportion of oxido-reductases and proteins related to lipid metabolism (LM), besides a lower proportion of proteins acting on polysaccharides, in comparison to four-month-old internodes. It was possible to note that sugarcane leaves and young stems have the highest LM rate than all species, which was assumed to be linked to cuticle formation...
December 23, 2017: Proteomics
https://www.readbyqxmd.com/read/29273412/versatility-of-microglial-bioenergetic-machinery-under-starving-conditions
#15
Adam M Nagy, Rebeka Fekete, Gergo Horvath, Gabor Koncsos, Csilla Kriston, Anna Sebestyen, Zoltan Giricz, Zsuzsanna Kornyei, Emilia Madarasz, Laszlo Tretter
Microglia are highly dynamic cells in the brain. Their functional diversity and phenotypic versatility brought microglial energy metabolism into the focus of research. Although it is known that microenvironmental cues shape microglial phenotype, their bioenergetic response to local nutrient availability remains unclear. In the present study effects of energy substrates on the oxidative and glycolytic metabolism of primary - and BV-2 microglial cells were investigated. Cellular oxygen consumption, glycolytic activity, the levels of intracellular ATP/ADP, autophagy, mTOR phosphorylation, apoptosis and cell viability were measured in the absence of nutrients or in the presence of physiological energy substrates: glutamine, glucose, lactate, pyruvate or ketone bodies...
December 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29242826/a-triassic-plesiosaurian-skeleton-and-bone-histology-inform-on-evolution-of-a-unique-body-plan
#16
Tanja Wintrich, Shoji Hayashi, Alexandra Houssaye, Yasuhisa Nakajima, P Martin Sander
Secondary marine adaptation is a major pattern in amniote evolution, accompanied by specific bone histological adaptations. In the aftermath of the end-Permian extinction, diverse marine reptiles evolved early in the Triassic. Plesiosauria is the most diverse and one of the longest-lived clades of marine reptiles, but its bone histology is least known among the major marine amniote clades. Plesiosaurians had a unique and puzzling body plan, sporting four evenly shaped pointed flippers and (in most clades) a small head on a long, stiffened neck...
December 2017: Science Advances
https://www.readbyqxmd.com/read/29240609/effects-of-propofol-on-cellular-bioenergetics-in-human-skeletal-muscle-cells
#17
Adéla Krajčová, Nils Gunnar Løvsletten, Petr Waldauf, Vladimír Frič, Moustafa Elkalaf, Tomáš Urban, Michal Anděl, Jan Trnka, G Hege Thoresen, František Duška
OBJECTIVES: Propofol may adversely affect the function of mitochondria and the clinical features of propofol infusion syndrome suggest that this may be linked to propofol-related bioenergetic failure. We aimed to assess the effect of therapeutic propofol concentrations on energy metabolism in human skeletal muscle cells. DESIGN: In vitro study on human skeletal muscle cells. SETTINGS: University research laboratories. SUBJECTS: Patients undergoing hip surgery and healthy volunteers...
December 13, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29235209/contrasting-above-and-belowground-organic-matter-decomposition-and-carbon-and-nitrogen-dynamics-in-response-to-warming-in-high-arctic-tundra
#18
Daan Blok, Samuel Faucherre, Imre Banyasz, Riikka Rinnan, Anders Michelsen, Bo Elberling
Tundra regions are projected to warm rapidly during the coming decades. The tundra biome holds the largest terrestrial carbon pool, largely contained in frozen permafrost soils. With warming, these permafrost soils may thaw and become available for microbial decomposition, potentially providing a positive feedback to global warming. Warming may directly stimulate microbial metabolism but may also indirectly stimulate organic matter turnover through increased plant productivity by soil priming from root exudates and accelerated litter turnover rates...
December 13, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29228180/longitudinal-structural-and-molecular-neuroimaging-in-agrammatic-primary-progressive-aphasia
#19
Katerina A Tetzloff, Joseph R Duffy, Heather M Clark, Edythe A Strand, Mary M Machulda, Christopher G Schwarz, Matthew L Senjem, Robert I Reid, Anthony J Spychalla, Nirubol Tosakulwong, Val J Lowe, Clifford R Jack, Keith A Josephs, Jennifer L Whitwell
The agrammatic variant of primary progressive aphasia affects normal grammatical language production, often occurs with apraxia of speech, and is associated with left frontal abnormalities on cross-sectional neuroimaging studies. We aimed to perform a detailed assessment of longitudinal change on structural and molecular neuroimaging to provide a complete picture of neurodegeneration in these patients, and to determine how patterns of progression compare to patients with isolated apraxia of speech (primary progressive apraxia of speech)...
December 8, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29224189/acute-loss-of-adipose-tissue-derived-adiponectin-triggers-immediate-metabolic-deterioration-in-mice
#20
Jonathan Y Xia, Kai Sun, Chelsea Hepler, Alexandra L Ghaben, Rana K Gupta, Yu A An, William L Holland, Thomas S Morley, Andrew C Adams, Ruth Gordillo, Christine M Kusminski, Philipp E Scherer
AIM/HYPOTHESIS: Adiponectin (APN), a circulating hormone secreted by mature adipocytes, has been extensively studied because it has beneficial metabolic effects. While many studies have focused on the congenital loss of APN and its effects on systemic body glucose and lipid metabolism, little is known about the effects triggered by acute loss of APN in the adult mouse. We anticipated that genetically induced acute depletion of APN in adult mice would have a more profound effect on systemic metabolic health than congenital deletion of Adipoq, the gene encoding APN, with its associated potential for adaptive responses that may mask the phenotypes...
December 9, 2017: Diabetologia
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