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Schistosoma mansoni

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https://www.readbyqxmd.com/read/28107750/effect-of-clinically-approved-hdac-inhibitors-on-plasmodium-leishmania-and-schistosoma-parasite-growth
#1
Ming Jang Chua, Megan S J Arnold, Weijun Xu, Julien Lancelot, Suzanne Lamotte, Gerald F Späth, Eric Prina, Raymond J Pierce, David P Fairlie, Tina S Skinner-Adams, Katherine T Andrews
Malaria, schistosomiasis and leishmaniases are among the most prevalent tropical parasitic diseases and each requires new innovative treatments. Targeting essential parasite pathways, such as those that regulate gene expression and cell cycle progression, is a key strategy for discovering new drug leads. In this study, four clinically approved anti-cancer drugs (Vorinostat, Belinostat, Panobinostat and Romidepsin) that target histone/lysine deacetylase enzymes were examined for in vitro activity against Plasmodium knowlesi, Schistosoma mansoni, Leishmania amazonensis and L...
December 23, 2016: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28104494/thoughts-on-interactions-between-pgrmc1-and-diverse-attested-and-potential-hydrophobic-ligands
#2
REVIEW
Michael A Cahill, Amy E Medlock
Progesterone Receptor Membrane Component 1 (PGRMC1) is located in many different subcellular locations with many different attested and probably location-specific functions. PGRMC1 was recently identified in the mitochondrial outer membrane where it interacts with ferrochelatase, the last enzyme in the heme synthetic pathway. It has been proposed that PGRMC1 may act as a chaperone to shuttle newly synthesized heme from the mitochondrion to cytochrome P450 (cyP450) enzymes. Here we consider potential roles that PGRMC1 may play in transferring heme, and other small hydrophobic ligands such as cholesterol and steroids, between the hydrophobic compartment of the membrane lipid bilayer interior to aqueous proteins, and perhaps to the membranes of other organelles...
January 16, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28095839/erratum-to-ceratonia-siliqua-pod-extract-ameliorates-schistosoma-mansoni-induced-liver-fibrosis-and-oxidative-stress
#3
Ebtesam M Al-Olayan, Manal F El-Khadragy, Reem A Alajmi, Mohamed S Othman, Amira A Bauomy, Shaimaa R Ibrahim, Ahmed E Abdel Moneim
No abstract text is available yet for this article.
January 17, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28095417/schistosoma-mansoni-infection-of-mice-rats-and-humans-elicits-a-strong-antibody-response-to-a-limited-number-of-reduction-sensitive-epitopes-on-five-major-tegumental-membrane-proteins
#4
Greice Krautz-Peterson, Michelle Debatis, Jacqueline M Tremblay, Sergio C Oliveira, Akram A Da'dara, Patrick J Skelly, Charles B Shoemaker
Schistosomiasis is a major disease of the developing world for which no vaccine has been successfully commercialized. While numerous Schistosoma mansoni worm antigens have been identified that elicit antibody responses during natural infections, little is known as to the identities of the schistosome antigens that are most prominently recognized by antibodies generated through natural infection. Non-reducing western blots probed with serum from schistosome-infected mice, rats and humans on total extracts of larval or adult schistosomes revealed that a small number of antigen bands predominate in all cases...
January 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28079240/new-index-for-the-diagnosis-of-liver-fibrosis-in-schistosomiasis-mansoni
#5
Ana Virgínia Matos Sá Barreto, Vinícius Martins Alecrim, Tibério Batista de Medeiros, Ana Lúcia Coutinho Domingues, Edmundo Pessoa Lopes, João Roberto Maciel Martins, Helena Bonciani Nader, George Tadeu Nunes Diniz, Silvia Maria Lucena Montenegro, Clarice Neuenschwander Lins de Morais
BACKGROUND: - Periportal fibrosis is the major pathological consequence of the Schistosoma mansoni infection. OBJECTIVE: - To evaluate the accuracy of serum markers and to construct an index to assess fibrosis. METHODS: - Patients (n=116) with schistosomiasis were evaluated by ultrasound scan and measurements of serum levels of aminotransferases, γ-glutamyl transferase, alkaline phosphatase, hyaluronic acid, cytokines and platelets. Ultrasound images were used to evaluate the fibrosis using Niamey's classification and identified 19 patients without periportal fibrosis (patterns A and B), 48 with mild to moderate fibrosis (C and D) and 49 with advanced fibrosis (E and F)...
January 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28057071/parasitic-infections-and-maternal-anaemia-among-expectant-mothers-in-the-dangme-east-district-of-ghana
#6
Samuel Crowther Kofi Tay, Emmanuel Agbeko Nani, Williams Walana
BACKGROUND: Parasitic infections are of public health concern globally, particular among at risk groups such as pregnant women in developing countries. The presence of these parasites during pregnancy potentiate adverse effects to both the mother and the unborn baby. This study sought to establish the prevalence of some parasitic agents among antenatal attendees in the Dangme East District of Ghana. A cross-sectional prospective study was conduct between April and July, 2012. Venous blood specimens were collected from each participant for haemoglobin estimation and malaria microscopy...
January 3, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28040484/development-of-an-experimental-model-of-schistosomal-myeloradiculopathy
#7
Tiago Pinheiro Vaz de Carvalho, Teresa Cristina Abreu Ferrari, Josimari Melo de Santana, Victor Antônio Santos Viana, José Aislan Correia Santos, Wheverton Correia do Nascimento, Kamilla Mayara Lucas da Cruz, Karina Conceição Gomes Machado de Araújo
Schistosomal myeloradiculopathy (SMR) is a severe form of presentation of schistosomiasis in which Schistosoma spp. affect the spinal cord. The aims of the present study were to develop an animal model of SMR caused by S. mansoni, to characterize both sensory and motor abnormalities in the infected animals, and to investigate the relationship of the sensory, motor and histological findings with the progression of the infection over time. Mechanical sensitivity and behavioral tests were performed followed by euthanasia in male Wistar rats divided into six groups of five animals each, on days 5, 10, 20 and 30 after infection of S...
December 28, 2016: Acta Tropica
https://www.readbyqxmd.com/read/28040375/-epi-genetic-inheritance-in-schistosoma-mansoni-a-systems-approach
#8
REVIEW
Céline Cosseau, Olaf Wolkenhauer, Gilda Padalino, Kathrin K Geyer, Karl F Hoffmann, Christoph Grunau
The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by 'inheritance system'. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success...
December 28, 2016: Trends in Parasitology
https://www.readbyqxmd.com/read/28030359/exploring-possibilities-for-an-alternative-approach-in-experimental-schistosomiasis-mansoni-the-peritoneal-cavity-of-mice
#9
Vitor L T Mati, Rosilene S Bicalho, Alan L Melo
The schistosome oviposition and granuloma constitution in the peritoneal cavity of AKR/J mice were evaluated. Groups of mice intraperitoneally infected with cercariae of Schistosoma mansoni were weekly euthanized during the acute (56 to 84 days post-infection (DPI)) and chronic (147 to 175 DPI) phase of infection. Schistosome developmental stages obtained via peritoneal lavage and perfusion of the portal system were inspected, counted and fixed, and peritoneal granulomata were then processed for histology. The morphological characterization and quantitative analysis of peritoneal schistosome eggs and granulomata were for the first time performed, such as the demonstration of the viability of miracidia obtained there from...
March 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28030347/reduced-14c-methionine-uptake-and-fecundity-in-schistosoma-mansoni-females-treated-with-recombinant-tumor-necrosis-factor-%C3%AE-in-vitro
#10
M A Haseeb, Raag Agrawal, Bernard Fried
Recombinant human TNFα (rhTNFα) has previously been shown to reduce fecundity in Schistosoma mansoni adult females maintained in vitro without males, and adversely affect the uptake of [14C]-tyrosine, an amino acid required for schistosome vitellogenesis. Here we report on the effect of rhTNFα on [14C]-methionine uptake in both separated and paired females, and the effect of three different preparations of rTNFα on schistosome oviposition in vitro. In the absence of rhTNFa, separated females incorporated only 30% of the [14C]-methionine incorporated by paired females in a dose and time-dependent manner, suggesting low metabolic activity of females in the absence of males...
March 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28027317/infection-with-schistosoma-mansoni-has-an-effect-on-quality-of-life-but-not-on-physical-fitness-in-schoolchildren-in-mwanza-region-north-western-tanzania-a-cross-sectional-study
#11
Safari Kinung'hi, Pascal Magnussen, Godfrey Kaatano, Annette Olsen
BACKGROUND: Infection with Schistosoma mansoni negatively impact children's physical health and may influence their general well-being. The aim of this study was to investigate the effect of S. mansoni infections on a panel of morbidity indicators with emphasis on quality of life (PedsQL; measured in four different dimensions) and physical fitness (measured as VO2 max) among 572 schoolchildren aged 7-8 years. METHODOLOGY/PRINCIPAL FINDINGS: Prevalence of S. mansoni infections was 58...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28017859/antiparasitic-activity-of-menadione-vitamin-k3-against-schistosoma-mansoni-in-babl-c-mice
#12
Govind J Kapadia, Ingrid A O Soares, G Subba Rao, Fernanda R Badoco, Ricardo A Furtado, Mariana B Correa, Denise C Tavares, Wilson R Cunha, Lizandra G Magalhães
Schistosomiasis is one of the neglected tropical diseases affecting nearly quarter of a billion people in economically challenged tropical and subtropical countries of the world. Praziquantel (PZQ) is the only drug currently available to treat this parasitic disease in spite being ineffective against juvenile worms and concerns about developing resistance to treat reinfections. Our earlier in vitro viability studies demonstrated significant antiparasitic activity of menadione (MEN) (vitamin K3) against Schistosoma mansoni adult worms...
December 23, 2016: Acta Tropica
https://www.readbyqxmd.com/read/28017636/identification-and-first-characterization-of-smeps8-a-potential-interaction-partner-of-smtk3-and-ser-transcribed-in-the-gonads-of-schistosoma-mansoni
#13
C Buro, C Burmeister, T Quack, C G Grevelding
In eukaryotes the roles of protein kinases (PKs) regulating important biological processes such as growth and differentiation are well known. Molecular, biochemical, and physiological analyses trying to unravel principles of schistosome development have substantiated the importance for PKs also in this parasite. Amongst others the role of SmTK3 was studied, one of the first cellular PKs characterized from Schistosoma mansoni. Its function was demonstrated in mitogenic and differentiation processes in the gonads...
December 22, 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/28012902/first-characterization-of-viruses-from-freshwater-snails-of-the-genus-biomphalaria-the-intermediate-host-of-the-parasite-schistosoma-mansoni
#14
Richard Galinier, Guillaume Tetreau, Anaïs Portet, Silvain Pinaud, David Duval, Benjamin Gourbal
We report the genome sequence and organization of five viruses infecting snails of both Biomphalaria glabrata and Biomphalaria pfeifferi, which are vectors of the intestinal schistosomiasis. Four viruses presented a polyadenylated positive single strand RNA genome encoding one or two large open reading frames (ORFs) flanked by untranslated region. Conserved protein motifs typical of the picorna-like virus superfamily were identified in these viruses but they all presented different genome organization. Phylogenetic analysis confirmed their assignment to this superfamily...
December 22, 2016: Acta Tropica
https://www.readbyqxmd.com/read/28011341/how-schistosomes-alter-the-human-serum-proteome
#15
Akram A Da'dara, Giles Siddons, Melissa Icaza, Qiang Wang, Patrick J Skelly
Schistosomes are intravascular parasitic worms that cause the debilitating disease schistosomiasis. To better understand how these long-lived parasites may subvert host immune and hemostatic capabilities, we examine here the impact of adult Schistosoma mansoni worms on the human serum proteome. Normal human serum (150μl) was incubated at 37°C for one hour either in the presence or absence of adult worms (∼50 pairs). Thereafter parasites were removed, serum samples were labeled and their proteins resolved for comparative analysis by 2D-Differential in-Gel Electrophoresis (2D-DIGE)...
December 20, 2016: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28001223/in-vitro-antischistosomal-activity-of-venom-from-the-egyptian-snake-cerastes-cerastes
#16
Ehssan Ahmed Hassan, Mohamed Ahmed Abdel-Rahman, Mohamed Moussa Ibrahim, Maha Farid Mohamed Soliman
INTRODUCTION: We studied the potential in vitro antischistosomal activity of Cerastes cerastes venom on adult Schistosoma mansoni worms. METHODS: Live specimens of the horned viper snake, C. cerastes were collected from the Aswan Governorate (Egypt). Venom was collected from snakes by manual milking. Worms of S. mansoni were obtained from infected hamsters by perfusion and isolated from blood using phosphate buffer. Mortality rates of worms were monitored after 3 days of exposure to snake venom at LC50 and various sublethal concentrations (10, 5, 2...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27998383/efficacy-of-gold-nanoparticles-against-nephrotoxicity-induced-by-schistosoma-mansoni-infection-in-mice
#17
Mohamed A Dkhil, Mona F Khalil, Amira A Bauomy, Marwa Sm Diab, Saleh Al-Quraishy
OBJECTIVE: In this study, the ameliorative effects of gold nanoparticles (gold NP) on the renal tissue damage in Schistosoma mansoni (S. mansoni)-infected mice was investigated. METHODS: High-resolution transmission electron microscopy was used for the characterization of NP. The gold NP at concentrations of 250, 500, and 1000 μg/kg body weight were inoculated into S. mansoni-infected mice. RESULTS: The parasite caused alterations in the histological architecture...
2016: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/27990425/comparative-evaluation-of-anthelmintic-activity-of-edible-and-ornamental-pomegranate-ethanolic-extracts-against-schistosoma-mansoni
#18
Doaa A Yones, Dalia M Badary, Hesham M B Sayed, Soad A H Bayoumi, Azza A Khalifa, Ahmed M El-Moghazy
Due to the development of praziquantel (PZQ) schistosomes resistant strains, the discovery of new antischistosomal agents is of high priority in research. This work reported the in vitro and in vivo effects of the edible and ornamental pomegranate extracts against Schistosoma mansoni. Leaves and stem bark ethanolic extracts of both dried pomegranates were prepared at 100, 300, and 500 μg/mL for in vitro and 600 and 800 mg/kg for in vivo. Adult worms Schistosoma mansoni in RPMI-1640 medium for in vitro and S...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27986555/serological-approaches-for-the-diagnosis-of-schistosomiasis-a-review
#19
Rebecca Hinz, Norbert Georg Schwarz, Andreas Hahn, Hagen Frickmann
Schistosomiasis is a common disease in endemic areas of Sub-Saharan Africa, South America and Asia. It is rare in Europe, mainly imported from endemic countries due to travelling or immigration. Available methods for the diagnosis of schistosomiasis comprise microscopical, molecular and serological approaches, with the latter detecting antigens or antibodies associated with Schistosoma spp. infection. The serological approach is a valuable screening tool in low-endemicity settings and for travel medicine, though the interpretation of any diagnostic results requires knowledge of test characteristics and the patient's history...
December 13, 2016: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/27965144/mapping-of-schistosoma-mansoni-in-the-nile-delta-egypt-assessment-of-the-prevalence-by-the-circulating-cathodic-antigen-urine-assay
#20
Ayat A Haggag, Amal Rabiee, Khaled M Abd Elaziz, Albis F Gabrielli, Rehab Abdel Hay, Reda M R Ramzy
In line with WHO recommendations on elimination of schistosomiasis, accurate identification of all areas of residual transmission is a key step to design and implement measures aimed at interrupting transmission in low-endemic settings. To this purpose, we assessed the prevalence of active S. mansoni infection in five pilot governorates in the Nile Delta of Egypt by examining schoolchildren (6-15 years) using the Urine-Circulating Cathodic Antigen (Urine-CCA) cassette test; we also carried out the standard Kato-Katz (KK) thick smear, the monitoring and evaluation tool employed by Egypt's national schistosomiasis control programme...
December 11, 2016: Acta Tropica
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