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Schistosoma mansoni

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https://www.readbyqxmd.com/read/29782530/histone-methylation-changes-are-required-for-life-cycle-progression-in-the-human-parasite-schistosoma-mansoni
#1
David Roquis, Aaron Taudt, Kathrin K Geyer, Gilda Padalino, Karl F Hoffmann, Nancy Holroyd, Matt Berriman, Benoît Aliaga, Cristian Chaparro, Christoph Grunau, Ronaldo de Carvalho Augusto
Epigenetic mechanisms and chromatin structure play an important role in development. Their impact is therefore expected to be strong in parasites with complex life cycles and multiple, strikingly different, developmental stages, i.e. developmental plasticity. Some studies have already described how the chromatin structure, through histone modifications, varies from a developmental stage to another in a few unicellular parasites. However, this, to our knowledge, has never been done before in multicellular metazoan parasites...
May 21, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29779499/efficacy-of-artemisinin-naphthoquine-phosphate-against-schistosoma-haematobium-adult-flukes-dose-effect-relationship-and-tegumental-alterations
#2
S N El-Beshbishi, S El Bardicy, M Tadros, M Ayoub, A Taman
Schistosoma haematobium and Schistosoma mansoni infections have broadly overlapping geographical distributions. Praziquantel is the only treatment for human schistosomiasis, so drug tolerance and/or resistance are major concerns. Artemisinin-naphthoquine phosphate (CO-ArNp), an artemisinin-based combination therapy endorsed by the World Health Organization as a gold standard therapy for malaria, has also been identified as a promising treatment for S. mansoni. In this in vitro study, we tested the effect of 1-40 μg/ml CO-ArNp on S...
May 21, 2018: Journal of Helminthology
https://www.readbyqxmd.com/read/29774300/epidemiology-of-intestinal-parasite-infections-in-three-departments-of-south-central-c%C3%A3-te-d-ivoire-before-the-implementation-of-a-cluster-randomised-trial
#3
Gaoussou Coulibaly, Mamadou Ouattara, Kouassi Dongo, Eveline Hürlimann, Fidèle K Bassa, Naférima Koné, Clémence Essé, Richard B Yapi, Bassirou Bonfoh, Jürg Utzinger, Giovanna Raso, Eliézer K N'Goran
Hundreds of millions of people are infected with helminths and intestinal protozoa, particularly children in low- and middle-income countries. Preventive chemotherapy is the main strategy to control helminthiases. However, rapid re-infection occurs in settings where there is a lack of clean water, sanitation and hygiene. In August and September 2014, we conducted a cross-sectional epidemiological survey in 56 communities of three departments of south-central Côte d'Ivoire. Study participants were invited to provide stool and urine samples...
May 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29773076/risk-factors-for-schistosomiasis-in-an-urban-area-in-northern-c%C3%A3-te-d-ivoire
#4
Richard K M'Bra, Brama Kone, Yapi G Yapi, Kigbafori D Silué, Ibrahima Sy, Danielle Vienneau, Nagnin Soro, Guéladio Cissé, Jürg Utzinger
BACKGROUND: Schistosomiasis is a water-based disease transmitted by trematodes belonging to the genus Schistosoma. The aim of this study was to assess the relationship between the prevalence of schistosomiasis and access to water, sanitation and hygiene (WASH) and environmental and socioeconomic factors in the city of Korhogo, northern Côte d'Ivoire. METHODS: A cross-sectional study including 728 randomly selected households was conducted in Korhogo in March 2015...
May 18, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29772240/identification-and-characterization-of-the-zinc-finger-protein-sjzf-in-schistosoma-japonicum
#5
Ruixiang Zhang, Jian Li, Manyu Xiang, Qinghua Hong, Bin Xu, Wei Hu
Schistosomiasis represents one of the most prevalent parasitic infections affecting over 249 million people worldwide. The pathological damage is mainly caused by the eggs laid by female schistosomes. Zinc finger proteins (ZFPs) usually play critical roles in many biological functions. In this study, we cloned, identified and characterized the zinc finger protein SjZF of Schistosoma japonicum. SjZF ortholog proteins were also identified in S. mansoni, S. haematobium, Opisthorchis viverrini and O. sinensis. Fluorescence localization showed that SjZF was particularly expressed in the worm gut of both genders and the vitelline glands of females...
May 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29764454/screening-a-repurposing-library-the-medicines-for-malaria-venture-stasis-box-against-schistosoma-mansoni
#6
Valérian Pasche, Benoît Laleu, Jennifer Keiser
BACKGROUND: The development of new treatments against schistosomiasis is imperative but lacks commercial interest. Drug repurposing represents a suitable strategy to identify potential treatments, which have already unblocked several essential steps along the drug development path, hence reducing costs and timelines. Promoting this approach, the Medicines for Malaria Venture (MMV) recently distributed a drug repurposing library of 400 advanced lead candidates (Stasis Box). METHODS: All 400 compounds were initially tested in vitro against the larval stage of Schistosoma mansoni at 10 μM...
May 15, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29760143/developmental-sensitivity-in-schistosoma-mansoni-to-puromycin-to-establish-drug-selection-of-transgenic-schistosomes
#7
Hong-Bin Yan, Michael J Smout, Chuan Ju, Anne E Folley, Danielle E Skinner, Victoria H Mann, Alex Loukas, Wei Hu, Paul J Brindley, Gabriel Rinaldi
Schistosomiasis is considered the most important disease caused by helminth parasites, in terms of morbidity and mortality. Tools to facilitate gain- and loss- of-function approaches can be expected to precipitate the discovery of novel interventions, and drug selection of transgenic schistosomes would facilitate the establishment of stable lines of engineered parasites. Sensitivity of developmental stages of schistosomes to the aminonucleoside antibiotic puromycin was investigated. For the schistosomulum and sporocyst stages, viability was quantified by fluorescence microscopy following dual staining with fluorescein diacetate and propidium iodine...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29754441/schistosomicidal-activity-of-dihydrobenzofuran-neolignans
#8
Herbert J Dias, Andressa B Patrocínio, Mariana C Pagotti, Murilo J Fukui, Vanderlei Rodrigues, Lizandra G Magalhães, Antônio E M Crotti
We have evaluated the antischistosomal activity of synthetic dihydrobenzofuran neolignans (DBNs) derived from (±)-trans-dehydrodicoumarate dimethyl ester (1) and (±)-trans-dehydrodiferulate dimethyl ester (2) against adult Schistosoma mansoni worms in vitro. Compound 4 ((±)-4-O-acetyl-trans-dehydrodiferulate dimethyl ester) displays the most promising activity; at 200 μM, it kills 100±0% of worms after 24 h, which resembles the result achieved with praziquantel (positive control) at 1.56 μM. Hydrogenation of the double bond between C7' and C8', introduction of an additional methyl group at C3', and a double bond between C7 and C8 decreases the schistosomicidal activity of DBNs...
May 13, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29751755/determinants-of-schistosoma-mansoni-in-sanja-health-center-north-west-ethiopia
#9
Asrat Atsedeweyn Andargie, Agmas Sisay Abera
BACKGROUND: In developing countries, Schistosoma mansoni is one of the chronic but neglected tropical diseases. In sub-Saharan Africa, the disease affects over 250 million people with nearly 800 million are at risk. In Ethiopia, Schistosoma mansoni is one of the most prevalent parasitic diseases. The aim of this study was to determine the prevalence and identify the determinant factors of Schistosoma mansoni, in terms of some socio-demographic variables and risk factors. METHODS: A cross-sectional parasitological survey was conducted at Sanja health center, northwest Ethiopia from June 1 to June 30, 2015...
May 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29750792/epiisopilosine-alkaloid-has-activity-against-schistosoma-mansoni-in-mice-without-acute-toxicity
#10
Maria A Guimarães, Rosimeire N de Oliveira, Rebeca L de Almeida, Ana C Mafud, Ana L V Sarkis, Rayane Ganassin, Marcos P da Silva, Daniel B Roquini, Leiz M Veras, Tânia C H Sawada, Cristina D Ropke, Luis A Muehlmann, Graziella A Joanitti, Selma A S Kuckelhaus, Silmara M Allegretti, Yvonne P Mascarenhas, Josué de Moraes, José R S A Leite
Schistosomiasis is a disease caused by parasites of the genus Schistosoma, currently affecting more than 200 million people. Among the various species of this parasite that infect humans, S. mansoni is the most common. Pharmacological treatment is limited to the use of a single drug, praziquantel (PZQ), despite reports of parasite resistance and low efficacy. It is therefore necessary to investigate new potential schistosomicidal compounds. In this study, we tested the efficacy of epiisopilosine (EPIIS) in a murine model of schistosomiasis...
2018: PloS One
https://www.readbyqxmd.com/read/29746471/atypical-pharmacology-of-schistosome-trpa1-like-ion-channels
#11
Swarna Bais, Corbett T Berry, Xiaohong Liu, Gordon Ruthel, Bruce D Freedman, Robert M Greenberg
Parasitic flatworms of the genus Schistosoma cause schistosomiasis, a neglected tropical disease estimated to affect over 200 million people worldwide. Praziquantel is the only antischistosomal currently available for treatment, and there is an urgent need for new therapeutics. Ion channels play key roles in physiology and are targets for many anthelmintics, yet only a few representatives have been characterized in any detail in schistosomes and other parasitic helminths. The transient receptor potential (TRP) channel superfamily comprises a diverse family of non-selective cation channels that play key roles in sensory transduction and a wide range of other functions...
May 10, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29743881/host-defense-versus-immunosuppression-unisexual-infection-with-male-or-female-schistosoma-mansoni-differentially-impacts-the-immune-response-against-invading-cercariae
#12
Martina Sombetzki, Nicole Koslowski, Anne Rabes, Sonja Seneberg, Franziska Winkelmann, Carlos Fritzsche, Micha Loebermann, Emil C Reisinger
Infection with the intravascular diecious trematode Schistosoma spp . remains a serious tropical disease and public health problem in the developing world, affecting over 258 million people worldwide. During chronic Schistosoma mansoni infection, complex immune responses to tissue-entrapped parasite eggs provoke granulomatous inflammation which leads to serious damage of the liver and intestine. The suppression of protective host immune mechanisms by helminths promotes parasite survival and benefits the host by reducing tissue damage...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29743617/complete-mitochondrial-and-rdna-complex-sequences-of-important-vector-species-of-biomphalaria-obligatory-hosts-of-the-human-infecting-blood-fluke-schistosoma-mansoni
#13
Si-Ming Zhang, Lijing Bu, Martina R Laidemitt, Lijun Lu, Martin W Mutuku, Gerald M Mkoji, Eric S Loker
Using high throughput Illumina sequencing technology, we determined complete sequences for the mitochondrial genome (mitogenome) and nuclear ribosomal DNA (rDNA) complex for three African freshwater snail taxa within the genus Biomphalaria, B. pfeifferi, B. sudanica and B. choanomphala, and for two laboratory strains of B. glabrata originating from the Neotropics. Biomphalaria snails are obligate vectors of the blood fluke Schistosoma mansoni, a major etiologic agent of human intestinal schistosomiasis. Our data show that mitogenomes from African and Neotropical Biomphalaria are highly conserved...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29743096/discovery-of-the-pyridylphenylureas-as-novel-molluscicides-against-the-invasive-snail-biomphalaria-straminea-intermediate-host-of-schistosoma-mansoni
#14
Weisi Wang, Qiang Mao, Junmin Yao, Weijia Yang, Qiming Zhang, Wencheng Lu, Zhuohui Deng, Liping Duan
BACKGROUND: The snail Biomphalaria straminea is one of the intermediate hosts of Schistosoma mansoni. Biomphalaria straminea is also an invasive species, known for its strong capability on peripheral expansion, long-distance dispersal and colonization. Using molluscicides to control snail populations is an important strategy to interrupt schistosomiasis transmission and to prevent the spread of the invasive species. In this study, a series of pyridylphenylurea derivatives were synthesized as potential molluscicides...
May 9, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29741139/identification-characterization-and-molecular-modelling-studies-of-schistosoma-mansoni-dihydrofolate-reductase-inhibitors-from-assay-development-to-hit-identification
#15
Andre Lacerda Braga Teles, Roseane R Silva, Michelle Ko, Glaucio Monteiro Ferreira, Samuel da Rocha Pita, Gustavo Henrique Goulart Trossini, Paulo Carvalho, Marcelo Santos Castilho
Schistosoma mansoni is responsible for virtually all reported cases of schistosomiasis in Latin America and the emergence of praziquantel- and oxaminiquine-resistant strains makes it urgent to develop new schistosomicide agents. Dihydrofolate reductases (DHFR) from bacteria and protozoan parasites are considered validated macromolecular targets for this goal, but S. mansoni DHFR (SmDHFR) has been largely overlooked. To fill this gap in knowledge, the present work describes optimized conditions to carry out thermal shift assays with SmDHFR, as well as a balanced kinetic assay that supports 2,4-diaminopyrimidine derivatives as SmDHFR inhibitors...
May 9, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29739616/schistosoma-egg-induced-liver-pathology-resolution-by-sm-p80-based-schistosomiasis-vaccine-in-baboons
#16
Loc Le, Adebayo J Molehin, Stewart Nash, Souad R Sennoune, Gul Ahmad, Workineh Torben, Weidong Zhang, Afzal A Siddiqui
Schistosomiasis remains a serious chronic debilitating hepato-intestinal disease. Current control measures based on mass drug administration are inadequate due to sustained re-infection rates, low treatment coverage and emergence of drug resistance. Hence, there is an urgent need for a schistosomiasis vaccine for disease control. In this study, we assessed the anti-pathology efficacy of Schistosoma mansoni large subunit of calpain (Sm-p80)-based vaccine against schistosomiasis caused by infections with Schistosoma mansoni in baboons...
May 5, 2018: Pathology
https://www.readbyqxmd.com/read/29737636/a-peroxiredoxin-based-proteinaceous-scaffold-for-the-growth-and-differentiation-of-neuronal-cells-and-tumour-stem-cells-in-the-absence-of-prodifferentiation-agents
#17
Annamaria Cimini, Matteo Ardini, Roberta Gentile, Francesco Giansanti, Elisabetta Benedetti, Loredana Cristiano, Alessia Fidoamore, Stefano Scotti, Gloria Panella, Francesco Angelucci, Rodolfo Ippoliti
The use of nanoscale materials in the design of scaffolds for CNS tissue is increasing, due to their ability to promote cell adhesion, to mimic an extracellular matrix microenvironment and to interact with neuronal membranes. In this framework, one of the major challenges when using undifferentiated neural cells is how to control the differentiation process. Here we report the characterization of a scaffold based on the self-assembled nanotubes of a mutant of the protein peroxiredoxin (from Schistosoma mansoni or Bos taurus), which allows the growth and differentiation of a model neuronal cell line (SHSY5Y)...
September 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29736731/phthalimido-thiazole-as-privileged-scaffold-activity-against-immature-and-adult-worms-of-schistosoma-mansoni
#18
Sheilla Andrade de Oliveira, Miria de Oliveira Barbosa, Carlos André Laranjeira Miranda Filho, Arsênio Rodrigues Oliveira, Fabiano Amaro de Sousa, Edna de Farias Santiago, Gevanio Bezerra de Oliveira Filho, Paulo André Teixeira de Moraes Gomes, Juliana Maria da Conceição, Fábio André Brayner, Luiz Carlos Alves, Ana Cristina Lima Leite
Phthalimide, 1,3-thiazole, and thiazolidinone cores are considered privileged scaffolds and represent an attractive starting point to design new bioactive compounds for neglected tropical disease (NTD). Schistosomiasis is a NTD, caused by Schistosoma worms which praziquantel (PZQ) is the only drug used to treat humans, but the decrease in the effect after treatment has been reported. Recently, some phthalimide-thiazole derivatives exhibited in vitro antischistosomal activity against adult worms with significant ultrastructural changes and a lower cytotoxic effect on splenocytes...
May 7, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29718924/socioenvironmental-factors-associated-with-schistosoma-mansoni-infection-and-intermediate-hosts-in-an-urban-area-of-northeastern-brazil
#19
Taíssa Alice Soledade Calasans, Geza Thais Rangel Souza, Claudia Moura Melo, Rubens Riscala Madi, Verónica de Lourdes Sierpe Jeraldo
Schistosomiasis, which is caused by trematodes of the genus Schistosoma and by the species Schistosoma mansoni in Brazil, is transmitted primarily by Biomphalaria glabrata mollusks. Infections occur in humans and mollusks in freshwater environments contaminated with feces from infected humans. This study aimed to evaluate potential foci of schistosomiasis based on the identification of infection sites for the snails, factors that increased the human infection probability of S. mansoni infection, and the relationship of the disease with abiotic, biotic, and sociocultural factors...
2018: PloS One
https://www.readbyqxmd.com/read/29716664/effects-of-callistemon-citrinus-aqueous-extract-on-prepatent-and-patent-infections-with-schistosoma-mansoni-in-experimentally-infected-mice
#20
S A El-Refai, A F Atia, S F Mahmoud
Schistosomiasis is a chronic debilitating parasitic disease that causes hepatic damage and is known to be endemic in developing countries. Recent control strategies for schistosomiasis depend exclusively on chemotherapeutic agents, specifically praziquantel. Unfortunately, praziquantel has low efficacy in the early phase of infection, and resistance to treatment is increasingly reported. The aim of this work was to find an alternative treatment by assessing the in vivo activity of aqueous extract of Callistemon citrinus against Schistosoma mansoni in both prepatent and patent phases in experimentally infected mice...
May 2, 2018: Journal of Helminthology
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