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Schistosoma mansoni

Afona Chernet, Andreas Neumayr, Christoph Hatz, Kerstin Kling, Véronique Sydow, Katharina Rentsch, Jürg Utzinger, Nicole Probst-Hensch, Hanspeter Marti, Beatrice Nickel, Niklaus D Labhardt
OBJECTIVES: Our study aimed at determining the prevalence of selected infectious diseases among recently arrived Eritrean refugees in Switzerland. METHODS: In this cross-sectional study, asymptomatic Eritrean migrants aged ≥16 years who arrived <24 months ago were recruited at refugee centres in Switzerland. Infectious disease screening included serology for HIV, hepatitis B and C, syphilis and schistosomiasis, polymerase chain reaction (PCR) for malaria, stool microscopy for helminths and intestinal protozoa and circulating cathodic antigen (CCA) testing in urine for schistosomiasis...
September 19, 2017: International Journal of Public Health
Helen L Storey, Benson Singa, Jackie Naulikha, Helen Horton, Barbra A Richardson, Grace John-Stewart, Judd L Walson
In many regions of sub-Saharan Africa, both HIV and helminth infections are prevalent. HIV-1 (human immunodeficiency virus type 1) and helminth infections can both compromise immune responses in humans. To determine whether the presence of helminth infection or the treatment of helminth infection alters unstimulated vaccine responses among HIV-1 infected individuals, we conducted two nested serologic studies. Blood samples were collected for HIV disease monitoring and vaccine-specific serologic assays, while stool was evaluated by direct microscopy methods...
February 2017: Parasite Epidemiology and Control
Luke F Pennington, Abdulaziz Alouffi, Evaristus C Mbanefo, Debalina Ray, David M Heery, Theodore S Jardetzky, Michael H Hsieh, Franco H Falcone
Urogenital schistosomiasis, caused by the parasitic trematode Schistosoma haematobium, affects over 112 million people worldwide. As with S. mansoni infections, the pathology in urogenital schistosomiasis is mainly related to the egg stage, which induces granulomatous inflammation of affected tissues. Schistosoma eggs and their secretions have been studied extensively for the related S. mansoni organism which is more amenable to laboratory studies. Indeed, we have shown that IPSE/alpha-1 (M-IPSE herein), a major protein secreted from S ...
September 18, 2017: Infection and Immunity
Akua Obeng Forson, Isaac Arthur, Michael Olu-Taiwo, Kathrine Korkor Glover, Prince Jonathan Pappoe-Ashong, Patrick F Ayeh-Kumi
OBJECTIVE: This study aimed to determine the prevalence and establish some risk factors associated with the acquisition of gastrointestinal parasitic infections in school children in Accra, Ghana. RESULTS: The overall prevalence of intestinal parasitic infection was 15%. Giardia lamblia (10%) and Schistosoma mansoni (1.7%) were the common parasites found. Out of the 15% students postive for intestinal parasites, 13.6% had single parasites and 1.3% had double parasitic infections...
September 18, 2017: BMC Research Notes
Cynthia Lenaerts, Jolien Palmans, Elisabeth Marchal, Rik Verdonck, Jozef Vanden Broeck
Venus kinase receptors (VKR) are a subfamily of invertebrate receptor tyrosine kinases, which have only recently been discovered. They contain an intracellular tyrosine kinase domain and an extracellular Venus FlyTrap domain. VKRs have been functionally and pharmacologically characterized in only two invertebrate species, namely the human parasite Schistosoma mansoni and the mosquito Aedes aegypti, where they play a crucial role in oogenesis. Here, we report the characterization of a VKR in the desert locust, Schistocerca gregaria...
September 15, 2017: Scientific Reports
Ramona Hurdayal, Hlumani H Ndlovu, Mélanie Revaz-Breton, Suraj P Parihar, Justin Komguep Nono, Melissa Govender, Frank Brombacher
Interleukin-4 (IL-4)-induced T helper (Th) 2 cells promote susceptibility to the protozoan parasite Leishmania major, while conferring immunity to the intestinal trematode Schistosoma mansoni Here, we report that abrogation of IL-4 receptor alpha (IL-4Rα) signaling on B cells in BALB/c mice (mb1(cre)IL-4Rα(-/lox)) transformed nonhealer BALB/c to a healer phenotype with an early type 1 and dramatically reduced type 2 immune response and an absence of ulceration and necrosis during cutaneous leishmaniasis. From adoptive reconstitution and mixed bone-marrow chimera studies in B cell-deficient (µMT) mice, we reveal a central role for B cell-derived IL-4 and IL-4Rα in the optimal induction of the susceptible type 2 phenotype to L...
September 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
Kátia B Amaral, Thiago P Silva, Felipe F Dias, Kássia K Malta, Florence M Rosa, Sócrates F Costa-Neto, Rosana Gentile, Rossana C N Melo
The pathology of schistosomiasis mansoni, a neglected tropical disease of great clinical and socioeconomic importance, results from the parasite eggs that become trapped in host tissues, particularly in the liver and intestines. Continuous antigenic stimulation from these eggs leads to recruitment of inflammatory cells to the sites of infection with formation of periovular granulomas. These complex structures have variable size and composition and are the most striking histopathological feature of schistosomiasis mansoni...
2017: PloS One
Limei Wen, Guodong Lü, Shuai Lu, Huijing Gao, Bei Chen, Yunfang Ma, Yuan Yuan, Haibo Zhang, Yunfeng Xiao, Hui Liu, Jun Zhao, Jianhua Wang
Ribosomal protein S9 (RPS9) is an essential functional gene that participate in DNA repair and developmental regulations. A sequence homolog of RPS9 has been found to be upregulated in the protoscoleces (PSCs) of Echinococcus granulosus treated with artemisinin (ART). However, Echinococcus granulosus RPS9 (EgRPS9) has not been identified before. In the present study, the 657 bp cDNA encoding EgRPS9 was cloned. Amino acid sequence analysis showed that EgRPS9 was similar to the RSP9 proteins from Schistosoma japonicum (SjRPS9, 86 %) and Schistosoma mansoni (SmRPS9, 79 %)...
September 13, 2017: Journal of Parasitology
Enyara R Morais, Katia C Oliveira, Renato G de Paula, Alice M M Ornelas, Érika B C Moreira, Fernanda Rafacho Badoco, Lizandra G Magalhães, Sergio Verjovski-Almeida, Vanderlei Rodrigues
Proteasome is a proteolytic complex responsible for intracellular protein turnover in eukaryotes, archaea and in some actinobacteria species. Previous work has demonstrated that in Schistosoma mansoni parasites, the proteasome inhibitor MG-132 affects parasite development. However, the molecular targets affected by MG-132 in S. mansoni are not entirely known. Here, we used expression microarrays to measure the genome-wide changes in gene expression of S. mansoni adult worms exposed in vitro to MG-132, followed by in silico functional analyses of the affected genes using Ingenuity Pathway Analysis (IPA)...
2017: PloS One
Alba Otoni, Carlos Mauricio de Figueiredo Antunes, Fernanda Ferreira Tavares, Débora Heloísa Quadros Araújo, Thiago de Almeida Pereira, Leonardo Campos de Queiroz, Frederico Figueiredo Amâncio, José Roberto Lambertucci
Introduction: Thrombocytopenia is commonly found in patients living in highly endemic areas for Schistosoma mansoni. Recently, different degrees of liver steatosis have also been associated with low platelet counts worldwide. We investigated the association of platelet counts with hepatosplenic schistosomiasis and with liver steatosis in an area of low prevalence of schistosomiasis in Brazil. Method: Pains, a city in the state of Minas Gerais, Brazil, had a population of 8,307 inhabitants and a schistosomiasis prevalence of 8%...
June 2017: Revista da Associação Médica Brasileira
Leonardo Souza Alves, Cesar Estanislau, Lucio Barreto, Francisco Batista, Nivaldo Toppa
Sumary The identification of a escrotal mass without pain or report of trauma should be investigated to rule out scrotal cancer. We report the case of a young Brazilian boy who underwent orchiectomy after magnetic resonance imaging (MRI) and duplex scan (DS) indicating a high possibility of cancer. Blood exams ruled out the possibility of cancer. Testicular biopsy was not indicated. After surgery the diagnostic was extensive orchiepididymitis by Schistosoma. In endemic areas orchiepididymis by Schistosoma should be investigate to avoid unnecessary surgeries...
June 2017: Revista da Associação Médica Brasileira
Elton J R Vasconcelos, Lucas F daSilva, David S Pires, Guilherme M Lavezzo, Adriana S A Pereira, Murilo S Amaral, Sergio Verjovski-Almeida
Next Generation Sequencing (NGS) strategies, like RNA-Seq, have revealed the transcription of a wide variety of long non-coding RNAs (lncRNAs) in the genomes of several organisms. In the present work we assessed the lncRNAs complement of Schistosoma mansoni, the blood fluke that causes schistosomiasis, ranked among the most prevalent parasitic diseases worldwide. We focused on the long intergenic/intervening ncRNAs (lincRNAs), hidden within the large amount of information obtained through RNA-Seq in S. mansoni (88 libraries)...
September 5, 2017: Scientific Reports
Evans Asena Chadeka, Sachiyo Nagi, Toshihiko Sunahara, Ngetich Benard Cheruiyot, Felix Bahati, Yuriko Ozeki, Manabu Inoue, Mayuko Osada-Oka, Mayuko Okabe, Yukio Hirayama, Mwatasa Changoma, Keishi Adachi, Faith Mwende, Mihoko Kikuchi, Risa Nakamura, Yombo Dan Justin Kalenda, Satoshi Kaneko, Kenji Hirayama, Masaaki Shimada, Yoshio Ichinose, Sammy M Njenga, Sohkichi Matsumoto, Shinjiro Hamano
BACKGROUND: Large-scale schistosomiasis control programs are implemented in regions with diverse social and economic environments. A key epidemiological feature of schistosomiasis is its small-scale heterogeneity. Locally profiling disease dynamics including risk factors associated with its transmission is essential for designing appropriate control programs. To determine spatial distribution of schistosomiasis and its drivers, we examined schoolchildren in Kwale, Kenya. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a cross-sectional study of 368 schoolchildren from six primary schools...
September 2017: PLoS Neglected Tropical Diseases
Danielle Gomes Marconato, Michélia Antônia do Nascimento Gusmão, Juliana Melo, Juciane Maria de Andrade Castro, Gilson Costa Macedo, Eveline Gomes Vasconcelos, Priscila de Faria-Pinto
NTPDases are enzymes that hydrolyze di- and tri-phosphate nucleosides, regulating purinergic signaling in many organisms. The Schistosoma mansoni NTPDases, SmATPDases 1 and 2 are antigenic proteins and display a significant homology with the isoforms found in mammalian cells. In this work, we investigated whether anti-SmATPDase antibodies from S. mansoni-infected mice sera show cross-reactivity with the NTPDase 1 isoform from macrophages and how this event affect the cell proliferation. By Western blot, anti-SmATPDase antibodies present in serum from infected mice recognized two bands with approximately 53 and 58 kDa, corresponding to NTPDase 1...
August 30, 2017: Parasite Immunology
Mohamed A Dkhil, Mona F Khalil, Marwa S M Diab, Amira A Bauomy, Saleh Al-Quraishy
Schistosomiasis is still one of the main parasitic diseases that affect human health in tropical regions. Whilst praziquantel (PZQ) is the main classic antischistosomal drug, the need for new drugs is still a must due to the low effectiveness of the drug on the schistosome young worms, and the evolving of PZQ resistant strains. Nanotechnology is one of the most important recent and current methods used to treat human diseases including parasitic ones. Therefore, the present study aimed to examine the curative role of gold nanoparticles (GNPs) on splenic tissue of mice infected with Schistosoma mansoni Sambon, 1907...
September 2017: Saudi Journal of Biological Sciences
Marwa H El-Faham, Maha M Eissa, Joseph E Igetei, Eglal I Amer, Susan Liddell, Mervat Z El-Azzouni, Michael J Doenhoff
BACKGROUND: Miltefosine, an anti-cancer drug that has been successfully repositioned for treatment of Leishmania infections, has recently also shown promising effects against Schistosoma spp targeting all life cycle stages of the parasite. The current study examined the effect of treating Schistosoma mansoni adult worms with miltefosine on exposure of worm surface antigens in vitro. METHODOLOGY/PRINCIPAL FINDINGS: In an indirect immunofluorescence assay, rabbit anti-S...
August 2017: PLoS Neglected Tropical Diseases
Alice Maria de M Ornelas, Renato G de Paula, Enyara R Morais, Lizandra G Magalhães, Annielle M B da Silva, Matheus S Gomes, William de Castro-Borges, Vanderlei Rodrigues
VIP36 is a protein described as an L-type lectin in animals, responsible for the intracellular transport of glycoproteins within the secretory pathway, and also localized on the plasma membrane. Schistosoma mansoni has a complex system of vesicles and protein transport machinery to the cell surface. The excreted/secreted products of the larvae and eggs are known to be exposed to the host immune system. Hence, characterizing the role and action of SmVIP36 in the S. mansoni life cycle is important for a better understanding of the parasite-host relationship...
August 24, 2017: Parasitology Research
Michael E Omobhude, Olajumoke A Morenikeji, Oyetunde T Oyeyemi
BACKGROUND: Snail intermediate host control is a widely canvassed strategy for schistosomiasis control in endemic countries. While there have been increasing studies on the search for potent molluscicides in the past years, the use of nanoparticulate agents as molluscicides is yet to gain wide attention. The aim of this study was to assess the molluscicidal potential of curcumin-nisin poly lactic acid (PLA) entrapped nanoparticle (CurNisNp) against Biomphalaria pfeifferi, a snail intermediate host for Schistosoma mansoni...
August 2017: PLoS Neglected Tropical Diseases
Gustavo Fernandes Godoy Almeida, Filipe Wanick Sarinho, Paula Carvalho de Abreu E Lima, Joao Bosco Oliveira Filho, Maxwell Alex de Lima Moura, Lais Neares Barbosa Ribeiro, Bruno Rolim de Brito, Mariana Montenegro de Melo Lira, Marcelo do Rego Maciel Souto Maior, Ana Lucia Coutinho Domingues
No abstract text is available yet for this article.
August 2017: Journal of Global Oncology
Zhigang Lu, Florian Sessler, Nancy Holroyd, Steffen Hahnel, Thomas Quack, Matthew Berriman, Christoph G Grevelding
RNA-Seq has proven excellence in providing information about the regulation and transcript levels of genes. We used this method for profiling genes in the flatworm Schistosoma mansoni. This parasite causes schistosomiasis, an infectious disease of global importance for human and animals. The pathology of schistosomiasis is associated with the eggs, which are synthesized as a final consequence of male and female adults pairing. The male induces processes in the female that lead to the full development of its gonads as a prerequisite for egg production...
August 22, 2017: Scientific Data
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