keyword
MENU ▼
Read by QxMD icon Read
search

Schistosoma mansoni

keyword
https://www.readbyqxmd.com/read/29331278/impact-of-treatment-with-a-protein-tyrosine-kinase-inhibitor-genistein-on-acute-and-chronic-experimental-schistosoma-mansoni-infection
#1
Maysa Mohamed Kamel Sobhy, Soheir Sayed Mahmoud, Shaimaa Helmy El-Sayed, Enas Mohamed Ali Rizk, Amira Raafat, Mohamed Sherif Ismail Negm
Schistosomiasis mansoni is considered one of the most common fibrotic diseases resulting from inflammation and deposition of fibrous tissue around parasitic eggs trapped in the liver, causing morbidity and mortality. Chemotherapy against schistosomiasis is largely dependent on Praziquantel (PZQ). Yet, the huge administration of it in endemic areas and its incompetence towards the immature stages have raised serious alarms against the development of drug resistance. Few drugs are directed to reverse schistosomal liver fibrosis, particularly at the chronic and advanced stages of the disease...
January 10, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29317884/evaluation-of-the-anti-schistosomal-effects-of-turmeric-curcuma-longa-versus-praziquantel-in-schistosoma-mansoni-infected-mice
#2
Atef Hussein, Samia Rashed, Ibrahim El Hayawan, Rabab El-Sayed, Hemat Ali
Background: Curcumin is the major active ingredient of Curcuma longa L., traditionally known as turmeric and has been shown to exhibit a wide range of pharmacological activities including anti-parasitic effect. However, it is found to be water-insoluble and has low bioavailability. The aim of this study was to explore the potential role of turmeric solved in olive oil either alone or in combination with praziquantel (PZQ) in treatment of schistosomiasis mansoni. Methods: The whole turmeric powder suspended in olive oil (as a solvent) is indicated to S...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29317164/progress-in-antischistosomal-n-n-diaryl-urea-sar
#3
Jianbo Wu, Chunkai Wang, Derek Leas, Mireille Vargas, Karen L White, David M Shackleford, Gong Chen, Austin G Sanford, Ryan M Hemsley, Paul H Davis, Yuxiang Dong, Susan A Charman, Jennifer Keiser, Jonathan L Vennerstrom
N,N'-Diaryl ureas have recently emerged as a new antischistosomal chemotype. We now describe physicochemical profiling, in vitro ADME, plasma exposure, and ex vivo and in vivo activities against Schistosoma mansoni for twenty new N,N'-diaryl ureas designed primarily to increase aqueous solubility, but also to maximize structural diversity. Replacement of one of the 4-fluoro-3-trifluoromethylphenyl substructures of lead N,N'-diaryl urea 1 with azaheterocycles and benzoic acids, benzamides, or benzonitriles decreased lipophilicity, and in most cases, increased aqueous solubility...
December 29, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29313478/schistosomiasis-and-infertility-in-east-africa
#4
Patricia A Woodall, Michael R Kramer
Case reports and pathology series suggest associations of female genital schistosomiasis (Schistosoma haematobium) with infertility and ectopic pregnancy. Differential geographic distribution of infertility is not explained by analyses of known risk factors. In this cross-sectional multilevel semi-ecologic study, interpolated prevalence maps for S. haematobium and Schistosoma mansoni in East Africa were created using data from two open-access Neglected Tropical Diseases Databases. Prevalence was extracted to georeferenced survey sample points for Demographic and Health Surveys for Ethiopia, Kenya, Tanzania, and Uganda for 2000 and 2010...
January 8, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29310695/understanding-the-relationship-between-egg-and-antigen-based-diagnostics-of-schistosoma-mansoni-infection-pre-and-post-treatment-in-uganda
#5
Joaquín M Prada, Panayiota Touloupou, Moses Adriko, Edridah M Tukahebwa, Poppy H L Lamberton, T Déirdre Hollingsworth
BACKGROUND: Schistosomiasis is a major socio-economic and public health problem in many sub-Saharan African countries. After large mass drug administration (MDA) campaigns, prevalence of infection rapidly returns to pre-treatment levels. The traditional egg-based diagnostic for schistosome infections, Kato-Katz, is being substituted in many settings by circulating antigen recognition-based diagnostics, usually the point-of-care circulating cathodic antigen test (CCA). The relationship between these diagnostics is poorly understood, particularly after treatment in both drug-efficacy studies and routine monitoring...
January 8, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29309602/glucose-uptake-in-the-human-pathogen-schistosoma-mansoni-is-regulated-through-akt-pkb-signalling
#6
Maxine McKenzie, Ruth S Kirk, Anthony J Walker
In Schistosoma mansoni the facilitated glucose transporter SGTP4, expressed uniquely in the apical surface tegumental membranes of the parasite, imports glucose from host blood to support its growth, development and reproduction. However, the molecular mechanisms that underpin glucose uptake in this blood fluke are not understood. Here, through functional characterization/mapping of S. mansoni Akt, we discover a vital role for Akt signalling in this process. We find that Akt, which could be activated by host insulin and L-arginine, was active in the tegument layer of both schistosomules and adult worms...
December 22, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29308085/could-mycobacterium-avium-subspecies-paratuberculosis-cause-crohn-s-disease-ulcerative-colitis%C3%A2-and-colorectal-cancer
#7
Ellen S Pierce
Infectious agents are known causes of human cancers. Schistosoma japonicum and Schistosoma mansoni cause a percentage of colorectal cancers in countries where the respective Schistosoma species are prevalent. Colorectal cancer is a complication of ulcerative colitis and colonic Crohn's disease, the two main forms of idiopathic inflammatory bowel disease (IIBD). Mycobacterium avium subspecies paratuberculosis (MAP), the cause of a chronic intestinal disease in domestic and wild ruminants, is one suspected cause of IIBD...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29295718/systematic-review-and-meta-analysis-on-schistosoma-mansoni-infection-prevalence-and-associated-risk-factors-in-brazil
#8
Maria Teresinha Gomes Casavechia, Gessilda de Alcântara Nogueira de Melo, Andrea Claudia Bekner Da Silva Fernandes, Karin Reinhold De Castro, Raissa Bocchi Pedroso, Thaís Da Silva Santos, Jorge Juarez Vieira Teixeira
We performed a systematic review and meta-analysis on the prevalence and factors associated with Schistosoma mansoni infection in Brazil. We searched the PubMed, Web of Science and Latin-American and Caribbean System on Health Sciences Information (LILACS) databases, scientific publications articles, according to The PRISMA Statement, from 2000 to 2016. A total of 27 studies were included according to the established criteria. The prevalence of S. mansoni infection varied widely, from 0·1 to 73·1%, based on Kato-Katz technique...
January 3, 2018: Parasitology
https://www.readbyqxmd.com/read/29276074/kinases-molecular-stage-directors-for-schistosome-development-and-differentiation
#9
REVIEW
Christoph G Grevelding, Simone Langner, Colette Dissous
Understanding schistosome biology is still a challenging mission. The reproductive biology of this parasitic trematode is closely associated with the pathologic consequences of schistosomiasis, the devastating infectious disease caused by members of the family Schistosomatidae worldwide. Recent studies of signaling mechanisms confirmed the prominent roles of protein kinases (PKs) in directing schistosome biology, and first evidence was obtained for an additional contribution of kinases with substrates different from proteins (non-PKs)...
December 21, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/29273443/some-facts-on-south-asian-schistosomiasis-and-need-for-international-collaboration
#10
REVIEW
M C Agrawal, V G Rao
In this review, we are discussing South Asian schistosomiasis; more specifically species which are responsible for schistosomiasis in India or South Asia -Schistosoma indicum, S. spindale, S. nasale, S. incognitum, S. gimvicum (S.haematobium), Bivitellobilharzia nairi, Orientobilharzia bomfordi, O. dattai, O. turkestanicum and O.harinasutai, their survival strategies such as mild pathology to the host, producing low egg number and utilizing fresh water snails (Indoplanorbis exustus and Lymnaea luteola) in stagnant water bodies like ponds, lakes, ditches, low laying areas, marshy lands and rice fields...
December 19, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29239481/the-self-curing-phenomenon-of-schistosome-infection-in-rhesus-macaques-insight-from-in-vitro-studies
#11
Workineh Torben, Adebayo J Molehin, Robert V Blair, Carys Kenway, Faith Shiro, Davis Roslyn, Bayissa Chala, Dereje Gutu, Michael A Kebede, Gul Ahmad, Weidong Zhang, Pyone Aye, Mahesh Mohan, Andrew Lackner, Afzal A Siddiqui
A reduction in the burden of schistosomiasis is potentially achievable by integrating a schistosomiasis vaccine with current control measures. Here, we determine parasite-specific in vitro responses of B, T, and NK cells from naive uninfected rhesus macaques to Schistosoma mansoni (Sm) egg (SmEA) and worm antigen (SmWA) preparations isolated from infected baboons. Pronounced B cell responses to SmEA and NK cell responses to both SmEA and SmWA were observed. High levels of IL-2 and IL-21 responses against Sm antigens were observed in T and non-T cells of lymph nodes (LNs) and gut lamina propria-derived lymphocytes (LPLs)...
November 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29229760/functional-characterization-of-the-ca2-atpase-sma1-from-schistosoma-mansoni
#12
Xavier Maréchal, Ricardo De Mendonça, Roger Miras, Jean Revilloud, Patrice Catty
Schistosoma mansoni is a parasite that causes bilharzia, a neglected tropical disease affecting hundreds of millions of people each year worldwide. In 2012, S. mansoni had been identified as the only invertebrate possessing two SERCA-type Ca2+-ATPases, SMA1 and SMA2. However, our analysis of recent genomic data shows that the presence of two SERCA pumps is rather frequent in parasitic flatworms. To understand the reasons of this redundancy in S. mansoni , we compared SMA1 and SMA2 at different levels. In terms of sequence and organization, the genes SMA1 and SMA2 are similar, suggesting that they might be the result of a duplication event...
December 11, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29228974/central-nervous-system-transcriptome-of-biomphalaria-alexandrina-an-intermediate-host-for-schistosomiasis
#13
Tamer A Mansour, Mohamed R Habib, Laura C Vicente Rodríguez, Anthony Hernández Vázquez, Julián Maldonado Alers, Alfredo Ghezzi, Roger P Croll, C Titus Brown, Mark W Miller
OBJECTIVE: Globally, more than 200 million people live at risk of the neglected tropical disease schistosomiasis (or snail fever). Larval schistosomes require the presence of specific snail species that act as intermediate hosts, supporting their multiplication and transformation into forms that can infect humans. This project was designed to generate a transcriptome from the central nervous system (CNS) of Biomphalaria alexandrina, the major intermediate host for Schistosoma mansoni in Egypt...
December 11, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29228024/detection-of-duo-schistosome-infection-from-filtered-urine-samples-from-school-children-in-zambia-after-mda
#14
Megan J Hessler, Austin Cyrs, Steven C Krenzke, El Shaimaa Mahmoud, Chummy Sikasunge, James Mwansa, Nilanjan Lodh
Schistosomiasis is one of the major Neglected Tropical Diseases (NTDs) in sub-Saharan Africa. In sub-Saharan Africa, two major human schistosome species namely Schistosoma mansoni and S. haematobium often occur sympatrically largely affecting children. Recognizing the public health impact of Schistosomiasis, the World Health Organization (WHO) is urging member states to regularly treat at least 75% and up to 100%, of all school-aged children at risk of morbidity. For control strategies based on targeted mass drug administration (MDA) to succeed it is essential to have a simple and sensitive test for monitoring the success of these interventions...
2017: PloS One
https://www.readbyqxmd.com/read/29225201/3-bromopyruvate-as-a-potential-pharmaceutical-in-the-light-of-experimental-data
#15
Izabela Szczuka, Andrzej Gamian, Grzegorz Terlecki
3-Bromopyruvate (3-BrPA) is an halogenated analogue of pyruvic acid known for over four decades as an alkylating agent reacting with thiol groups of many proteins. It enters animal cells like a lactate: via monocarboxylic acid transporters. Increasing interest in this compound, in recent times, is mainly due to hopes associated with its anticancer action. It is based on the impairment of energy metabolism of tumor cells by inhibiting enzymes in the glycolysis pathway (hexokinase II, glyceraldehyde 3-phosphate dehydrogenase, phosphoglycerate kinase) and the oxidative phosphorylation (succinate dehydrogenase)...
December 8, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29220354/interpreting-ambiguous-trace-results-in-schistosoma-mansoni-cca-tests-estimating-sensitivity-and-specificity-of-ambiguous-results-with-no-gold-standard
#16
Michelle N Clements, Christl A Donnelly, Alan Fenwick, Narcis B Kabatereine, Sarah C L Knowles, Aboulaye Meité, Eliézer K N'Goran, Yolisa Nalule, Sarah Nogaro, Anna E Phillips, Edridah Muheki Tukahebwa, Fiona M Fleming
BACKGROUND: The development of new diagnostics is an important tool in the fight against disease. Latent Class Analysis (LCA) is used to estimate the sensitivity and specificity of tests in the absence of a gold standard. The main field diagnostic for Schistosoma mansoni infection, Kato-Katz (KK), is not very sensitive at low infection intensities. A point-of-care circulating cathodic antigen (CCA) test has been shown to be more sensitive than KK. However, CCA can return an ambiguous 'trace' result between 'positive' and 'negative', and much debate has focused on interpretation of traces results...
December 8, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29217943/intestinal-parasitosis-and-their-associated-factors-among-people-living-with-hiv-at-university-of-gondar-hospital-northwest-ethiopia
#17
Tegegne Eshetu, Getinet Sibhatu, Mohammed Megiso, Abrham Abere, Habtamu Wondifraw Baynes, Belete Biadgo, Ayalew Jejaw Zeleke
Background: Most HIV clients die of AIDS related intestinal parasitic infections rather than due to the HIV infection itself. Therefore, this study was aimed at determining the prevalence of intestinal parasite and their associated factors among HIV/AIDS clients at the University of Gondar Hospital, Northwest Ethiopia. Methods: Institution based cross sectional study was conducted using systematic random sampling technique from March to May 2016. A semi-structured questionnaire was used to collect data...
July 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29202865/prevalence-and-intensity-of-schistosoma-mansoni-infections-among-schoolchildren-attending-primary-schools-in-an-urban-setting-in-southwest-ethiopia
#18
Mitiku Bajiro, Daniel Dana, Bruno Levecke
OBJECTIVE: To determined both prevalence and intensity of Schistosoma mansoni infections among schoolchildren attending primary schools in Jimma town, an urban setting, Southwest, Ethiopia. RESULTS: The prevalence of S. mansoni infections was 8.4%. S. mansoni infections were found in all 17 schools, but the school prevalence ranged from 1.7 to 26.7%. This variation in prevalence could be explained by the proximity of the schools to the river crossing the town and water bodies near the schools...
December 4, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29197426/phenotypic-and-genotypic-monitoring-of-schistosoma-mansoni-in-tanzanian-schoolchildren-five-years-into-a-preventative-chemotherapy-national-control-programme
#19
Charlotte M Gower, Florian Gehre, Sara R Marques, Poppy H L Lamberton, Nicholas J Lwambo, Joanne P Webster
BACKGROUND: Schistosoma mansoni is a parasite of profound medical importance. Current control focusses on mass praziquantel (PZQ) treatment of populations in endemic areas, termed Preventative Chemotherapy (PC). Large-scale PC programmes exert prolonged selection pressures on parasites with the potential for, direct and/or indirect, emergence of drug resistance. Molecular methods can help monitor genetic changes of schistosome populations over time and in response to drug treatment, as well as estimate adult worm burdens through parentage analysis...
December 2, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29183397/schistosomiasis-intestinal-helminthiasis-and-nutritional-status-among-preschool-aged-children-in-sub-urban-communities-of-abeokuta-southwest-nigeria
#20
Adebiyi Abdulhakeem Adeniran, Hammed Oladeji Mogaji, Adeyinka A Aladesida, Ibiyemi O Olayiwola, Akinola Stephen Oluwole, Eniola Michael Abe, Dorcas B Olabinke, Oladimeji Michael Alabi, Uwem Friday Ekpo
OBJECTIVE: Schistosomiasis and intestinal helminthiasis are major public health problems with school-aged children considered the most at-risk group. Pre-school aged children (PSAC) are excluded from existing control programs because of limited evidence of infections burden among the group. We assessed the prevalence of infections and effect on nutritional status of preschool aged children in Abeokuta, Southwestern Nigeria. RESULTS: A community-based cross-sectional study involving 241 children aged 0-71 months was conducted in 4 sub-urban communities of Abeokuta...
November 28, 2017: BMC Research Notes
keyword
keyword
16457
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"