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Schistosoma mansoni

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https://www.readbyqxmd.com/read/29162144/schistosoma-mansoni-and-other-helminthes-infections-at-haike-primary-school-children-north-east-ethiopia-a-cross-sectional-study
#1
Daniel Getacher Feleke, Solomon Arega, Mulien Tekleweini, Kegnitu Kindie, Alemu Gedefie
OBJECTIVES: Schistosomiasis and soil-transmitted helminthes infections are among the widely distributed infections worldwide. In Ethiopia, parasitic helminthic infections and schistosomiasis are among the most predominant causes of outpatient morbidity. Hence there is still lack of epidemiological information in North-Eastern Ethiopia, this study aimed to determine the prevalence and associated factors of Schistosoma mansoni and other helminthes infections at Haike primary school children, Haike, North-East Ethiopia...
November 21, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29161330/fasciola-spp-mapping-of-the-mf6-epitope-and-antigenic-analysis-of-the-mf6p-hdm-family-of-heme-binding-proteins
#2
Victoria Martínez-Sernández, María J Perteguer, Mercedes Mezo, Marta González-Warleta, Teresa Gárate, M Adela Valero, Florencio M Ubeira
MF6p/FhHDM-1 is a small cationic heme-binding protein which is recognized by the monoclonal antibody (mAb) MF6, and abundantly present in parenchymal cells and secreted antigens of Fasciola hepatica. Orthologs of this protein (MF6p/HDMs) also exist in other causal agents of important foodborne trematodiasis, such as Clonorchis sinensis, Opisthorchis viverrini and Paragonimus westermani. Considering that MF6p/FhHDM-1 is relevant for heme homeostasis in Fasciola and was reported to have immunomodulatory properties, this protein is expected to be a useful target for vaccination...
2017: PloS One
https://www.readbyqxmd.com/read/29160513/detection-of-schistosomiasis-in-an-area-directly-affected-by-the-s%C3%A3-o-francisco-river-large-scale-water-transposition-project-in-the-northeast-of-brazil
#3
José Damião da Silva, Marta Cristhiany Cunha Pinheiro, Mariana Silva Sousa, Vivian da Silva Gomes, Issis Maria Nogueira de Castro, Alberto Novaes Ramos, Fernando Schemelzer de Moraes Bezerra
INTRODUCTION: The development of the São Francisco River Integration Project [Projeto de Integração do Rio São Francisco (PISF)] in the State of Ceará, Brazil, has resulted in environmental and socioeconomic changes with potential risks to public health. We aimed to determine the presence of Schistosoma mansoni infections in schoolchildren (aged 7-14 years) and workers from the construction site in an area under the direct influence of the PISF in the municipality of Brejo Santo-CE, to aid in the prevention and control of schistosomiasis...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29160512/evaluation-of-the-immunogenicity-of-schistosoma-mansoni-egg-surface
#4
Renata Russo Frasca Candido, Timothy Guy St Pierre, Malcolm Kenneth Jones, Carlos Graeff-Teixeira
INTRODUCTION: Immunogenicity of Schistosoma mansoni egg surface was examined to determine whether intact eggshells have lower antigenicity than ruptured eggs. METHODS: Swiss Webster mice were inoculated with intact or ultrasonicated S. mansoni eggs isolated from infected human feces. Mice were separated into four groups of six animals each and immunizations were performed approximately every 20 days during a 60-day period. Groups 1-4 were administered with saline solution, sonicated eggs with Freund's adjuvant, sonicated eggs without Freund's adjuvant, and intact eggs, respectively...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29155817/analysis-of-the-interactome-of-schistosoma-mansoni-histone-deacetylase-8
#5
Stéphanie Caby, Lucile Pagliazzo, Julien Lancelot, Jean-Michel Saliou, Nicolas Bertheaume, Raymond J Pierce, Emmanuel Roger
BACKGROUND: Histone deacetylase 8 from Schistosoma mansoni (SmHDAC8) is essential to parasite growth and development within the mammalian host and is under investigation as a target for the development of selective inhibitors as novel schistosomicidal drugs. Although some protein substrates and protein partners of human HDAC8 have been characterized, notably indicating a role in the function of the cohesin complex, nothing is known of the partners and biological function of SmHDAC8. METHODOLOGY/PRINCIPAL FINDINGS: We therefore employed two strategies to characterize the SmHDAC8 interactome...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29154994/evolutionary-epidemiology-of-schistosomiasis-linking-parasite-genetics-with-disease-phenotype-in-humans
#6
Tine Huyse, Nele A M Boon, Frederik Van den Broeck, Moustapha Mbow, Anurag Chaturvedi, Lynn Meurs, Filip A M Volckaert, Katja Polman
Here we assess the role of parasite genetic variation in host disease phenotype in human schistosomiasis by implementing concepts and techniques from environmental association analysis in evolutionary epidemiology. Schistosomiasis is a tropical disease that affects more than 200 million people worldwide and is caused by parasitic flatworms belonging to the genus Schistosoma. While the role of host genetics has been extensively studied and demonstrated, nothing is yet known on the contribution of parasite genetic variation to host disease phenotype in human schistosomiasis...
November 15, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/29147726/-radiculomyelopathy-in-schistosomiasis
#7
REVIEW
J Detzler, H Backes, J Guldner
The increasing migration of people from their homeland in far distant regions to Europe in the last few years has strongly influenced the rise of previously rarely seen diseases. They not only originate from the respective homeland but also from the transit countries during the migration process. We report the case of a 27-year-old male migrant from Eritrea, who after months of flight as a refugee travelling through various African countries, presented at our hospital with a progressive, painful radiculopathy...
November 16, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/29138640/prevalence-of-soil-transmitted-helminthiases-and-schistosomiasis-in-preschool-age-children-in-mwea-division-kirinyaga-south-district-kirinyaga-county-and-their-potential-effect-on-physical-growth
#8
Stephen Sifuna Wefwafwa Sakari, Amos K Mbugua, Gerald M Mkoji
Intestinal parasitic infections can significantly contribute to the burden of disease, may cause nutritional and energetic stress, and negatively impact the quality of life in low income countries of the world. This cross-sectional study done in Mwea irrigation scheme, in Kirinyaga, central Kenya, assessed the public health significance of soil-transmitted helminthiases (STH), schistosomiasis, and other intestinal parasitic infections, among 361 preschool age children (PSAC) through fecal examination, by measuring anthropometric indices, and through their parents/guardians, by obtaining sociodemographic information...
2017: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29131820/rapid-clearance-of-schistosoma-mansoni-circulating-cathodic-antigen-after-treatment-shown-by-urine-strip-tests-in-a-ugandan-fishing-community-relevance-for-monitoring-treatment-efficacy-and-re-infection
#9
Anna O Kildemoes, Birgitte J Vennervald, Edridah M Tukahebwa, Narcis B Kabatereine, Pascal Magnussen, Claudia J de Dood, André M Deelder, Shona Wilson, Govert J van Dam
ClinicalTrials.gov NCT00215267.
November 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29130972/human-dendritic-cells-with-th2-polarizing-capacity-analysis-using-label-free-quantitative-proteomics
#10
Leonie Hussaarts, Maria Mardalena Martini Kaisar, Arzu Tugce Guler, Hans Dalebout, Bart Everts, André M Deelder, Magnus Palmblad, Maria Yazdanbakhsh
BACKGROUND: Dendritic cells (DCs) are the sentinels of the immune system. Upon recognition of a pathogen, they mature and migrate to draining lymph nodes to prime and polarize T cell responses. Although it is known that helminths and helminth-derived molecules condition DCs to polarize T helper (Th) cells towards Th2, the underlying mechanisms remain incompletely understood. OBJECTIVES: The aim of this study was to conduct a proteome analysis of helminth antigen-stimulated DCs in order to gain more insight into the cellular processes associated with their ability to polarize immune responses...
November 10, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29128645/kunitz-type-protease-inhibitor-as-a-vaccine-candidate-against-schistosomiasis-mansoni
#11
Shiwanthi L Ranasinghe, Mary Duke, Marina Harvie, Donald P McManus
OBJECTIVES: To develop a vaccine against schistosomiasis, which is a major challenge due to the complex life cycle of the causative schistosome parasite. METHODS: SmKI-1 is a 16kDa Kunitz type protease inhibitor present in the excretory/secretory products and tegument of adult worms and eggs of Schistosoma mansoni. Two independent vaccine trials were carried out in mice to determine the efficacy of rSmKI-1 in developing protective immunity. RESULTS: The results obtained showed reductions of 23-33% in adult worms, 28-31% in intestinal eggs, 33-39% in fecal eggs and 20-43% in liver eggs...
November 8, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29124010/positive-fecal-occult-blood-test-as-a-diagnostic-cue-for-schistosoma-mansoni-infection-in-a-developed-country
#12
Itaru Nakamura, Kenji Yagi, Takashi Kumagai, Nobuo Ohta
The rise in eco-tourism and travel off the beaten track have increased numbers of tourists with schistosomiasis which is seldom seen in developed countries, although this disease is considered a neglected tropical disease especially in poor communities. A Guinean male living in Japan was seen complaining of severe constipation. He was positive for fecal occult blood (FOB) and underwent colonoscopy. Colonoscopy showed petechiae of the rectal mucosa, with pathologic examination of biopsy tissue showing calcified eggs of the genus Schistosoma...
2017: IDCases
https://www.readbyqxmd.com/read/29122387/protection-against-schistosoma-haematobium-infection-in-hamsters-by-immunization-with-schistosoma-mansoni-gut-derived-cysteine-peptidases-smcb1-and-smcl3
#13
Hatem Tallima, Marwa Abou El Dahab, Sahira Kareem, John Pius Dalton, Rashika El Ridi
We examined the immunogenicity and protective potential of SmCB1 and SmCL3 cysteine peptidases, alone and in combination, in hamsters challenged with S. haematobium. For each of two independent experiments, eight Syrian hamsters were immunized twice with a three week-interval with 0 (controls), 20 µg SmCB1, 20 µg SmCL3, or 10 µg SmCB1 plus 10 µg SmCL3, and then percutaneously exposed eight weeks later to 100 S. haematobium cercariae. Hamsters from each group were assessed for humoral and whole blood culture cytokine responses on day 10 post challenge infection, and examined for parasitological parameters 12 weeks post infection...
November 6, 2017: Vaccine
https://www.readbyqxmd.com/read/29120573/il-17-induced-the-recruitment-and-functional-activity-of-granulocytes-isolated-from-patients-coinfected-with-schistosoma-mansoni-and-hepatitis-c-virus
#14
Soad Nady, Gamal Esmat
The aim of this study was to investigate the role of Th17 cytokines on granulocytes recruitment and functional activity in Schistosoma mansoni/hepatitis C virus (HCV) co-infected patients. Granulocytes were isolated from the co-infected blood and stimulated overnight with Schistosoma soluble egg antigen (SEA) in the presence of IL-17, IL-22, or both cytokines. In parallel, granuloma was induced in vitro using the isolated granulocytes and SEA-coated polyacrylamide beads in the presence of IL-17 and/or IL-22 then the sizes of granulomas were measured after one week...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29114141/effect-of-phenyl-vinyl-sulphone-cysteine-protease-inhibitor-on-schistosoma-mansoni-in-vitro-and-in-vivo-experimental-studies
#15
Manal Salah El-Din Mahmoud, Ayman Nabil Ibrahim, Abeer Fathy Badawy, Nourhan Mohamed Abdelmoniem
The present work aimed to study the effect of phenyl vinyl sulphone (PVS), a CPI, on different stages of Schistosoma (S.) mansoni in an in vitro culture study and in experimentally infected mice, compared to PZQ. As regards the in vitro study, different concentrations of PVS (1, 2, 4, 6, 8 and 10 µg/ml) and PZQ (1 µg/ml) were assessed by % worm mortality for schistosomula and adults, and hemoglobin degradation by schistosomula. In vivo study included 8 groups of mice. Intraperitoneal PVS, subgroup (a), and oral PZQ, subgroup (b), were assessed at different durations post infection (pi); at 1, 3, 5 and 7 weeks pi (groups I, II, III and IV, respectively)...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29103268/schistosoma-mansoni-infection-and-its-related-morbidity-among-adults-living-in-selected-villages-of-mara-region-north-western-tanzania-a-cross-sectional-exploratory-study
#16
Humphrey D Mazigo, Fred Nuwaha, David W Dunne, Godfrey M Kaatano, Tekla Angelo, Stella Kepha, Safari M Kinung'hi
Schistosoma mansoni is highly endemic in Tanzania and affects all age groups at different degrees. However, its control approach does not include adult individuals who are equally at risk and infected. To justify the inclusion of adult individuals in MDA programs in Tanzania, the present study focused on determining the prevalence of S. mansoni infection and its related morbidities among adult individuals. This was a cross sectional study conducted among 412 adult individuals aged 18-89 years living in selected villages of Rorya and Butiama districts located along the shoreline of the Lake Victoria...
October 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29097241/laboratory-assessment-of-divaricatic-acid-against-biomphalaria-glabrata-and-schistosoma-mansoni-cercariae
#17
H A M F Silva, W N Siqueira, J L F Sá, L R S Silva, M C B Martins, A L Aires, F F Amâncio, E C Pereira, M C P A Albuquerque, A M M A Melo, N H Silva
In this study, the molluscicidal and antiparasitic activities of divaricatic acid was evaluated, targeting the mollusc Biomphalaria glabrata and cercariae of the helminth Schistosoma mansoni. In addition, the environmental toxicity of divaricatic acid was assessed by bioassay using the microcrustacean Artemia salina. Divaricatic acid showed high toxicity against both adult snails (5μg/mL) and embryos (20μg/mL after 6h of exposure). Similar activity was observed in Schistosoma mansoni cercariae after only a short exposure time (10μg/mL after 30min of exposure)...
October 31, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29094048/the-efficacy-of-single-dose-versus-double-dose-praziquantel-treatments-on-schistosoma-mansoni-infections-its-implication-on-undernutrition-and-anaemia-among-primary-schoolchildren-in-two-on-shore-communities-northwestern-tanzania
#18
David Z Munisi, Joram Buza, Emmanuel A Mpolya, Teckla Angelo, Safari M Kinung'hi
Administering more than one treatment may increase Praziquantel cure and egg reduction rates, thereby hastening achievement of schistosomiasis transmission control. A total of 431 S. mansoni-infected schoolchildren were randomized to receive either a single or repeated 40 mg/kg Praziquantel dose. Heights, weights, and haemoglobin levels were determined using a stadiometer, weighing scale, and HemoCue, respectively. At 8 weeks, cure rate was higher on repeated dose (93.10%) compared to single dose (68.68%) (p < 0...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29092797/gold-nanoparticles-against-parasites-and-insect-vectors
#19
REVIEW
Giovanni Benelli
Nanomaterials are currently considered for many biological, biomedical and environmental purposes, due to their outstanding physical and chemical properties. The synthesis of gold nanoparticles (Au NPs) is of high interest for research in parasitology and entomology, since these nanomaterials showed promising applications, ranging from detection techniques to drug development, against a rather wide range of parasites of public health relevance, as well as on insect vectors. Here, I reviewed current knowledge about the bioactivity of Au NPs on selected insect species of public health relevance, including major mosquito vectors, such as Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus...
October 29, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29074138/schistosoma-mansoni-in%C3%A2-vivo-evaluation-of-phyllanthus-amarus-hexanic-and-ethanolic-extracts
#20
Claudineide Nascimento Fernandes de Oliveira, Tarsila Ferraz Frezza, Vera Lúcia Garcia, Glyn Mara Figueira, Tiago Manuel Fernandes Mendes, Silmara Marques Allegretti
Human schistosomiasis is an important neglected tropical disease caused by blood flukes of the genus Schistosoma and is responsible for more than 280,000 deaths annually. Treatment for this disease relies currently on a single drug, praziquantel (PZQ). Concerns regarding PZQ resistance and insensitivity of juvenile schistosomes have increased the interest in resorting to medicinal plants for alternative drug therapies. This study aimed to perform an in vivo schistosomicidal activity evaluation of crude hexanic (HE) and ethanolic (EE) extracts obtained from Phyllanthus amarus in mice infected with Schistosoma mansoni (BH strain)...
October 23, 2017: Experimental Parasitology
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