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Schistosoma mansoni

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https://www.readbyqxmd.com/read/28817585/selecting-targets-for-the-diagnosis-of-schistosoma-mansoni-infection-an-integrative-approach-using-multi-omic-and-immunoinformatics-data
#1
Gardenia B F Carvalho, Daniela M Resende, Liliane M V Siqueira, Marcelo D Lopes, Débora O Lopes, Paulo Marcos Z Coelho, Andréa Teixeira-Carvalho, Jeronimo C Ruiz, Cristina T Fonseca
In order to effectively control and monitor schistosomiasis, new diagnostic methods are essential. Taking advantage of computational approaches provided by immunoinformatics and considering the availability of Schistosoma mansoni predicted proteome information, candidate antigens of schistosomiasis were selected and used in immunodiagnosis tests based on Enzime-linked Immunosorbent Assay (ELISA). The computational selection strategy was based on signal peptide prediction; low similarity to human proteins; B- and T-cell epitope prediction; location and expression in different parasite life stages within definitive host...
2017: PloS One
https://www.readbyqxmd.com/read/28817570/increased-hepatotoxicity-among-hiv-infected-adults-co-infected-with-schistosoma-mansoni-in-tanzania-a-cross-sectional-study
#2
Amon I Marti, Soledad Colombe, Peter J Masikini, Samuel E Kalluvya, Luke R Smart, Bahati M Wajanga, Hyasinta Jaka, Robert N Peck, Jennifer A Downs
INTRODUCTION: Little is known about hepatotoxicity in patients with schistosome and HIV co-infections. Several studies have reported increased liver enzymes and bilirubin levels associated with schistosome infection. We investigated whether HIV-infected adults on antiretroviral therapy who had S. mansoni co-infection had a higher prevalence of hepatotoxicity than those without. METHODOLOGY/PRINCIPAL FINDINGS: We determined the presence and grade of hepatotoxicity among 305 HIV-infected outpatients who had been on medium-term (3-6 months) and long-term (>36 months) antiretroviral therapy in a region of northwest Tanzania where S...
August 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28814579/hepatosplenic-schistosomiasis-playing-hide-and-seek-with-an-elusive-parasite
#3
Martin Baekby, Henning Glerup, Katrine Stribolt, Britta Tarp
A 27-year-old man of Eritrean origin presented with persistent left-sided abdominal pain. Initial investigation showed signs of liver fibrosis, portal hypertension and splenomegaly. A diagnosis of hepatosplenic schistosomiasis was suspected on grounds of elevated total IgE, grey area antischistosomiasis antibodies and the high endemic status of his native country. However, repeated microscopy of faecal and urine samples, as well as rectal biopsies, failed to demonstrate schistosomal eggs. Finally, the diagnosis of hepatosplenic schistosomiasis was established through demonstration of a Schistosoma mansoni egg in a liver biopsy taken in an attempt to clarify the cause of the above findings...
August 16, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28813451/schistosoma-mansoni-reinfection-analysis-of-risk-factors-by-classification-and-regression-tree-cart-modeling
#4
Andréa Gazzinelli, Roberta Oliveira-Prado, Leonardo Ferreira Matoso, Bráulio M Veloso, Gisele Andrade, Helmut Kloos, Jeffrey M Bethony, Renato M Assunção, Rodrigo Correa-Oliveira
Praziquantel (PZQ) is an effective chemotherapy for schistosomiasis mansoni and a mainstay for its control and potential elimination. However, it does not prevent against reinfection, which can occur rapidly in areas with active transmission. A guide to ranking the risk factors for Schistosoma mansoni reinfection would greatly contribute to prioritizing resources and focusing prevention and control measures to prevent rapid reinfection. The objective of the current study was to explore the relationship among the socioeconomic, demographic, and epidemiological factors that can influence reinfection by S...
2017: PloS One
https://www.readbyqxmd.com/read/28807888/spectroscopic-and-calorimetric-assays-reveal-dependence-on-dctp-and-two-metals-zn-2-mg-2-for-enzymatic-activity-of-schistosoma-mansoni-deoxycytidylate-dcmp-deaminase
#5
Jéssica Fernandes Scortecci, Vitor Hugo Balasco Serrão, Juliana Cheleski, Juliana Roberta Torini, Larissa Romanello, Ricardo DeMarco, Humberto D'Muniz Pereira
The parasite Schistosoma mansoni possess all pathways for pyrimidine biosynthesis, whereby deaminases play an essential role in the thymidylate cycle, a crucial step to controlling the ratio between cytidine and uridine nucleotides. In this study, we heterologously expressed and purified the deoxycytidylate (dCMP) deaminase from S. mansoni to obtain structural, biochemical and kinetic information. Small-angle X-ray scattering of this enzyme showed that it is organized as a hexamer in solution. Isothermal titration calorimetry was used to determine the kinetic constants for dCMP-dUMP conversion and the role of dCTP and dTTP in enzymatic regulation...
August 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28803793/schistosomiasis-from-a-snail-s-perspective-advances-in-snail-immunity
#6
REVIEW
Emmanuel A Pila, Hongyu Li, Jacob R Hambrook, Xinzhong Wu, Patrick C Hanington
The snail's immune response is an important determinant of schistosome infection success, acting in concert with host, parasite, and environmental factors. Coordinated by haemocytes and humoral factors, it possesses immunological hallmarks such as pattern recognition receptors, and predicted gastropod-unique factors like the immunoglobulin superfamily domain-containing fibrinogen-related proteins. Investigations into mechanisms that underpin snail-schistosome compatibility have advanced quickly, contributing functional insight to many observational studies...
August 11, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28803725/schistosomiasis-drugs-used-and-treatment-strategies
#7
REVIEW
Lidiany da Paixão Siqueira, Danilo Augusto Ferreira Fontesa, Cindy Siqueira Britto Aguilera, Taysa Renata Ribeiro Timoteo, Matheus Alves Angelos, Laysa Creusa Paes Barreto Barros Silva, Camila Gomes de Melo, Larissa Araújo Rolim, Rosali Maria Ferreira da Silva, Pedro José Rolim Neto
Neglected tropical diseases (NTDs) affect millions of people in different geographic regions, especially the poorest and most vulnerable. Currently NTDs are prevalent in 149 countries, seventeen of these neglected tropical parasitic diseases are classified as endemic. One of the most important of these diseases is schistosomiasis, also known as bilharzia, a disease caused by the genus Schistosoma. It presents several species, such as S. haematobium, S. japonicum and S. mansoni, the latter being responsible for parasitosis in Brazil...
August 10, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28796565/ultrastructural-changes-of-kidney-in-schistosoma-mansoni-infected-mice
#8
Refaat A Eid, Mubarak Al-Shraim, Fahmy El-Sayed, Khaled Radad
Schistosomiasis is the second threatening parasitic disease after malaria and among Schistosoma spp., Schistosoma mansoni (S. mansoni) affects about 100 million people in tropic regions in Africa and South America. The current study was carried out to investigate ultrastructural changes of the kidney in mice infected with cercariae of S. mansoni, in which 20 Swiss albino mice of 60-day-old were assigned into two groups (10 each). Control group received 1 ml normal saline by intraperitoneal route. Model group were intraperitoneally infected with 1 ml normal saline containing 40 cercariae of S...
August 10, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28783370/association-between-polymorphisms-of-the-mannose-binding-lectin-and-severity-of-periportal-fibrosis-in-schistosomiasis-in-the-northeast-of-brazil
#9
Taynan da Silva Constantino, Elker Lene Santos de Lima, Lidiane Régia Pereira Braga de Brito, Jamile Luciana Silva, Maria Rosângela Cunha Duarte Coêlho, Maria Tereza Cartaxo Muniz, Paula Carolina Valença Silva, Ana Lúcia Coutinho Domingues
AIMS: Mannose-binding lectin (MBL) is a protein synthesized by the liver and its immune response is associated with the development of liver fibrosis. We hypothesized that the polymorphisms in the Exon 1 region (52, 54, 57) and promoter regions (-550 H/L, -221 X/Y) of the MBL2 gene were associated with the severity of periportal fibrosis (PPF), and that these polymorphisms affect the MBL serum levels. MATERIALS AND METHODS: In this cross-sectional study we genotyped these polymorphisms within the MBL2 gene in 229 Brazilian subjects infected with Schistosoma mansoni, with different patterns of PPF...
August 7, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28780467/in-vitro-schistosomicidal-and-antiviral-activities-of-arctium-lappa-l-asteraceae-against-schistosoma-mansoni-and-herpes-simplex-virus-1
#10
Mirna Meana Dias, Ohana Zuza, Lorena R Riani, Priscila de Faria Pinto, Pedro Luiz Silva Pinto, Marcos P Silva, Josué de Moraes, Ana Caroline Z Ataíde, Fernanda de Oliveira Silva, Alzira Batista Cecílio, Ademar A Da Silva Filho
Schistosomiasis and herpes diseases represent serious issues to the healthcare systems, infecting a large number of people worldwide, mainly in developing countries. Arctium lappa L. (Asteraceae), known as "bardana" and "burdock", is a medicinal plant popularly used for several purposes, including as antiseptic. In this study, we evaluated the in vitro schistosomicidal and antiherpes activities of the crude extract of A. lappa, which have not yet been described. Fruits of A. lappa L. were extracted by maceration with ethanol: H2O (96:4 v/v) in order to obtain the hydroalcoholic extract of A...
August 3, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28777067/schistosoma-mansoni-cercarial-elastase-smce-differences-in-immunogenic-properties-of-native-and-recombinant-forms
#11
Marwa H El-Faham, Katherine J Wheatcroft-Francklow, Helen P Price, Jon R Sayers, Michael J Doenhoff
The Schistosoma mansoni cercarial elastase (SmCE) has previously been shown to be poorly immunogenic in mice. However, a minority of mice were able to produce antibodies against SmCE after multiple immunizations with crude preparations containing the enzyme. These mice were partially protected against challenge infections of S. mansoni. In the present study, we show that in contrast to the poor immunogenicity of the enzymatically active native form of SmCE derived from a crude preparation (cercarial transformation fluid), immunization of CBA/Ca mice with two enzymatically inactive forms, namely purified native SmCE or a recombinant SmCE fused to recombinant Schistosoma japonicum glutathione S-transferase (rSmCE-SjGST), after adsorption onto aluminum hydroxide adjuvant, induced specific anti-SmCE immunoglobulin G (IgG) in all mice within 2 weeks of the second immunization...
September 2017: Parasitology
https://www.readbyqxmd.com/read/28768520/colorectal-cancer-in-a-patient-with-intestinal-schistosomiasis-a-case-report-from-kilimanjaro-christian-medical-center-northern-zone-tanzania
#12
Ayesiga M Herman, Alfred Kishe, Heri Babu, Hilary Shilanaiman, Murad Tarmohamed, Jay Lodhia, Patrick Amsi, Jeremia Pyuza, Alex Mremi, Amos Mwasamwaja, Mramba Nyindo, Kondo Chilonga, David Msuya
BACKGROUND: Colorectal cancer associated with chronic intestinal schistosomiasis has been linked with the chronic inflammation as a result of schistosomal ova deposition in the submucosal layer of the intestine. Among all species Schistosoma japonicum has been more linked to development of colorectal cancer as compared to Schistosoma mansoni due to absence of population-based studies to support the association. Despite the weak evidence, some cases have been reported associating S. mansoni with development of colorectal cancer...
August 2, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28766154/the-comparative-effect-of-chlorine-and-huwa-san-as-disinfecting-agents-on-biomphalaria-alexandrina-snails-and-free-larval-stages-of-schistosoma-mansoni
#13
Sara S M Sayed, Marwa T A Abdel-Wareth
Many chemicals are applied for disinfecting purposes. Although chlorination is the most common procedure, it has many drawbacks. So there becomes an urgent need for new chemicals which are both effective and less harmful to other water fauna. The present work aims at investigating the comparative effects of chlorine and Huwa-san as a new disinfectant on Biomphalaria alexandrina snails which act as bioindicators of toxicity, besides evaluating their miracicidal and cercaricidal activities. The results showed that Huwa-san was more toxic on tested snails than chlorine, where the LC50 values were 21 and 1368...
August 2, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28764732/in-vitro-and-in-vivo-activity-of-r-and-s-praziquantel-enantiomers-and-the-main-human-metabolite-trans-4-hydroxy-praziquantel-against-schistosoma-haematobium
#14
Jana Kovač, Mireille Vargas, Jennifer Keiser
BACKGROUND: Praziquantel (PZQ) is the mainstay of schistosomiasis control and has been successfully used for decades. However, its mechanism of action is not fully understood. While the majority of studies have been conducted on Schistosoma mansoni, it is not known which enantiomer, R- or S-praziquantel (R-/S-PZQ), is responsible for the activity on Schistosoma haematobium. METHODS: In vitro and in vivo studies were conducted to evaluate the activity of R- and S-PZQ, racemic PZQ and the main human metabolite, namely trans-4-OH-PZQ, on S...
August 1, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28763497/diagnosis-of-coinfection-by-schistosomiasis-and-viral-hepatitis-b-or-c-using-1h-nmr-based-metabonomics
#15
Liana Ribeiro Gouveia, Joelma Carvalho Santos, Ronaldo Dionísio Silva, Andrea Dória Batista, Ana Lúcia Coutinho Domingues, Edmundo Pessoa de Almeida Lopes, Ricardo Oliveira Silva
BACKGROUND: Diagnosis of liver involvement due to schistosomiasis in asymptomatic patients from endemic areas previously diagnosed with chronic hepatitis B (HBV) or C (HCV) and periportal fibrosis is challenging. H-1 Nuclear Magnetic Resonance (NMR)-based metabonomics strategy is a powerful tool for providing a profile of endogenous metabolites of low molecular weight in biofluids in a non-invasive way. The aim of this study was to diagnose periportal fibrosis due to schistosomiasis mansoni in patients with chronic HBV or HCV infection through NMR-based metabonomics models...
2017: PloS One
https://www.readbyqxmd.com/read/28757393/a-comparative-study-on-the-anti-schistosomal-and-hepatoprotective-effects-of-vinpocetine-and-isosorbide-5-mononitrate-on-schistosoma-mansoni-infected-mice
#16
Samar M Alhusseiny, Samar N El-Beshbishi, Maha M Abu Hashim, Hosam El-Dein E El-Nemr, Aya E Handoussa
Schistosomiasis is a remarkable public health problem in developing countries. Presently, praziquantel is the optional drug for all human schistosomiasis. Owing to the increased praziquantel resistance, there is an urgent need to develop new alternatives. This study aims at determining the anti-schistosomal and/or the hepatoprotective effects of the anti-inflammatory drug; vinpocetine, and the vasodilator and the nitric oxide donor; isosorbide-5-mononitrate, in comparison to praziquantel. In the present research, the therapeutic efficacies of these drugs were assessed in Swiss albino female mice (CD-I strain) experimentally infected with an Egyptian strain of Schistosoma mansoni, using some general, parasitological, and histopathological parameters...
July 27, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28755871/cyclohexene-fused-1-3-oxazines-with-selective-antibacterial-and-antiparasitic-action-and-low-cytotoxic-effects
#17
Maria R M de Brito, Walter J Peláez, Martín S Faillace, Gardenia C G Militão, Jackson R G S Almeida, Gustavo A Argüello, Zsolt Szakonyi, Ferenc Fülöp, Maria C Salvadori, Fernanda S Teixeira, Rivelilson M Freitas, Pedro L S Pinto, Ana C Mengarda, Marcos P N Silva, Ademar A Da Silva Filho, Josué de Moraes
Oxazine derivatives, a class of heterocyclic compounds, exhibit a variety of biological properties, such as anticonvulsant and antitumor activities. In this study, we evaluated the effect of two cyclohexene-fused 1,3-oxazines (cis‑1-benzyl-N-phenyl-1,4,4a,5,8,8a-hexahydro-3,1-benzoxazin-2-imine (1) and trans‑N-phenyl-1,4,4a,5,8,8a-hexahydro-3,1-benzoxazin-2-imine (2)) in cultures of Bacillus cereus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Salmonella enterica, Serratia marcescens, Shigella flexneri and Staphylococcus aureus by the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC)...
July 26, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28754617/infection-by-schistosoma-mansoni-during-pregnancy-effects-on-offspring-immunity
#18
REVIEW
Vanessa Ribeiro Figliuolo da Paz, Danielly Sequeira, Alexandre Pyrrho
About 25 million Brazilians live in areas at risk of contracting the disease caused by the trematoda Schistosoma mansoni, the schistosomiasis mansoni. Although the adult parasites inhabit the blood vessels, probably the main element responsible for the pathology of the disease are the eggs, whose deposition in the liver results in formation of granulomas and hypersensitivity mediated by CD4 T cells. In the course of infection, the profile of T helper 1 (Th1) and Th2 cytokines released by immune cells is correlated with the extent of inflammation in the granuloma and with the disease severity...
July 25, 2017: Life Sciences
https://www.readbyqxmd.com/read/28754250/molecular-context-of-schistosoma-mansoni-transmission-in-the-molluscan-environments-a-mini-review
#19
REVIEW
Damilare Olatunji Famakinde
Schistosoma mansoni, being transmitted by some freshwater Biomphalaria snails, is a major causative agent of human schistosomiasis. In the absence of effective vaccine and alternative drug designs to fight against the disease, and with the limitations of molluscicide application, developing more efficient strategies to interrupt the snail-mediated parasite transmission is being emphasized as potentially instrumental in the efforts toward schistosomiasis elimination, hence, necessitating thorough and comprehensive understanding of the fundamental mechanisms involved in the transmission process...
July 25, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28753651/schistosome-egg-antigens-including-the-glycoprotein-ipse-alpha-1-trigger-the-development-of-regulatory-b-cells
#20
Simone Haeberlein, Katja Obieglo, Arifa Ozir-Fazalalikhan, Mathilde A M Chayé, Henrike Veninga, Luciën E P M van der Vlugt, Astrid Voskamp, Louis Boon, Joke M M den Haan, Lotte B Westerhof, Ruud H P Wilbers, Arjen Schots, Gabriele Schramm, Cornelis H Hokke, Hermelijn H Smits
Infection with the helminth Schistosoma (S.) mansoni drives the development of interleukin (IL)-10-producing regulatory B (Breg) cells in mice and man, which have the capacity to reduce experimental allergic airway inflammation and are thus of high therapeutic interest. However, both the involved antigen and cellular mechanisms that drive Breg cell development remain to be elucidated. Therefore, we investigated whether S. mansoni soluble egg antigens (SEA) directly interact with B cells to enhance their regulatory potential, or act indirectly on B cells via SEA-modulated macrophage subsets...
July 2017: PLoS Pathogens
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