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Postprandial lipemia

Elena M Yubero-Serrano, Javier Lopez-Moreno, Francisco Gomez-Delgado, Jose Lopez-Miranda
The beneficial effects of a Mediterranean diet on human health and, in particular, on lowering risk of cardiovascular disease, has been mainly attributed to its high content to extra virgin olive oil (EVOO). While its main fatty acid, oleic acid, is considered important to these effects, EVOO has other biological properties that depend on, or are potentiated by other minor components of this oil. Initially, the mechanisms considered as possible causes of this cardioprotective effect of EVOO were based on the incidence on the so-called traditional risk factors (especially lipids and blood pressure)...
November 28, 2018: European Journal of Clinical Nutrition
Beatriz Gomez-Marin, Francisco Gomez-Delgado, Javier Lopez-Moreno, Juan F Alcala-Diaz, Rosa Jimenez-Lucena, Jose D Torres-Peña, Antonio Garcia-Rios, Ana M Ortiz-Morales, Elena M Yubero-Serrano, Maria Del Mar Malagon, Chao Q Lai, Javier Delgado-Lista, Jose M Ordovas, Jose Lopez-Miranda, Pablo Perez-Martinez
Background: Patients with type 2 diabetes (T2D) have an elevated postprandial lipemia (PPL) that has been associated with increased cardiovascular risk. Objective: We aimed to analyze whether the long-term consumption of 2 healthy dietary patterns is associated with an improvement in PPL and remnant cholesterol (RC) concentrations in patients with T2D. Design: We selected patients from the Cordioprev study who underwent oral fat load tests (FLTs) at baseline and the 3-y follow-up (241 patients with and 316 patients without T2D)...
November 1, 2018: American Journal of Clinical Nutrition
Debapriya Basu, Lesley-Ann Huggins, Diego Scerbo, Joseph Obunike, Adam E Mullick, Paul L Rothenberg, Nicholas A Di Prospero, Robert H Eckel, Ira J Goldberg
Objective- SGLT2 (sodium-glucose cotransporter 2) inhibition in humans leads to increased levels of LDL (low-density lipoprotein) cholesterol and decreased levels of plasma triglyceride. Recent studies, however, have shown this therapy to lower cardiovascular mortality. In this study, we aimed to determine how SGLT2 inhibition alters circulating lipoproteins. Approach and Results- We used a mouse model expressing human CETP (cholesteryl ester transfer protein) and human ApoB100 (apolipoprotein B100) to determine how SGLT2 inhibition alters plasma lipoprotein metabolism...
September 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
Hansol Lee, Yeni Lim, Soo-Yeon Park, Soo-Muk Cho, Jeong-Sook Choe, Sewon Jeong, Jin Sook Kwak, Oran Kwon
BACKGROUND/OBJECTIVES: Elevation of postprandial lipemia characterized by a rise in triglyceride (TG)-rich lipoproteins can increase the risk of atherogenesis. The objective of this study was to investigate postprandial lipemia response to a single dietary fat/sugar load test and monitor beneficial changes induced by the consumption of Platycodi radix (AP) beverage in healthy subjects. SUBJECTS/METHODS: A total of 52 subjects were randomly assigned to either placebo or AP beverage group with a high-fat shake in a randomized controlled crossover trial...
October 2018: Nutrition Research and Practice
Amirsalar Samkani, Mads J Skytte, Mads N Thomsen, Arne Astrup, Carolyn F Deacon, Jens J Holst, Sten Madsbad, Jens F Rehfeld, Thure Krarup, Steen B Haugaard
Postprandial responses to food are highly dependent on the macronutrient composition of the diet. We investigated the acute effects of transition from the recommended moderately high carbohydrate (HC) diet towards a carbohydrate-reduced high-protein (CRHP) diet on postprandial glycemia, insulinemia, lipemia, and appetite-regulating hormones in non-diabetic adults. Fourteen subjects, including five males (Mean ± SD: age 62 ± 6.5; BMI 32 ± 7.6 kg/m²; hemoglobin A1c (HbA1c ) 40 ± 3.0 mmol/mol; HOMA2-IR 2...
September 12, 2018: Nutrients
Rodrigo Cauduro Oliveira Macedo, Francesco Pinto Boeno, Juliano Boufleur Farinha, Thiago Rozales Ramis, Josianne Rodrigues-Krause, Alexandra Ferreira Vieira, Jessica Queiroz, Cesar Eduardo Jacintho Moritz, Alvaro Reischak-Oliveira
PURPOSE: The addition of fructose to one or more meals daily may lead to increased postprandial lipemia (PPL). Aerobic exercise has been successful in preventing those increases; however, the duration of exercise effects is still unknown. The aim of this study was to evaluate the acute and residual effects of aerobic exercise and fructose ingestion on PPL. METHODS: Twelve young and sedentary men completed a crossover blinded randomized trial. On day 0, they performed 45 min of aerobic exercise at 60% of VO2peak , or 45 min of resting...
July 19, 2018: European Journal of Nutrition
Magdalena Del Rocío Sevilla-González, Carlos A Aguilar-Salinas, Liliana Muñóz-Hernández, Paloma Almeda-Valdés, Roopa Mehta, Rafael Zubirán, Omar Yaxmehen Bello-Chavolla, Donaji V Gómez-Velasco, Arsenio Vargas-Vázquez, Tannia Viveros-Ruíz, Alexandro J Martagón-Rosado, Ivette Cruz-Bautista
BACKGROUND: Postprandial lipemia is an important cardiovascular risk factor. The assessment of postprandial lipid metabolism is a newly trend that several consortiums and countries have adopted. The aim of the study is to determine a postprandial triglyceride concentration cut-off point that accurately discriminate individuals with fasting normal triglyceride concentrations from those with fasting hypertriglyceridemia. METHODS: Cross sectional population-based study...
July 18, 2018: Lipids in Health and Disease
Chih-Hui Chiu, Tsung-Jen Yang, Hong Jen Liang, Cheng-Kang Chang, Ching-Lin Wu
High plasma triglyceride (TG) concentration in fasting state could cause hemorheological abnormality, thus increasing the incidence of metabolic diseases. Exercise has been reported to effectively reduce postprandial TG response. This study aimed to investigate whether a single bout of pre-prandial exercise can affect lipemia and hemorheological variables after a high-fat meal. Nine healthy young male subjects completed two experimental trials. The subjects walked for 1 h at 50% maximal oxygen uptake (V̇O₂max) (the exercise, EX trial), or rested (the control, CON trial)...
June 2018: Chinese Journal of Physiology
A Macho-González, A Garcimartín, F Naes, M E López-Oliva, A Amores-Arrojo, M J González-Muñoz, S Bastida, J Benedí, F J Sánchez-Muniz
Increased postprandial lipemia is a cardiovascular disease (CVD) risk factor. Carob fruit extract (CFE) contains condensed tannins, and their intake has been inversely related to CVD. The objective was to evaluate the in vitro pancreatic lipase activity in the presence of CFE and the in vivo effect of CFE on postprandial lipemia of healthy Wistar rats in acute and subchronic digestibility studies and to relate it with changes in fat digestion and absorption. CFE significantly reduced pancreatic lipase activity...
July 5, 2018: Journal of Agricultural and Food Chemistry
Marjorie Boyer, Patricia L Mitchell, Paul Poirier, Natalie Alméras, Angelo Tremblay, Jean Bergeron, Jean-Pierre Després, Benoit J Arsenault
Cholesterol efflux capacities (CECs) are negatively associated with cardiovascular disease risk, irrespective of plasma high-density lipoprotein (HDL) cholesterol levels. Whether interventions targeting lifestyle improve HDL-CECs is unknown. Our objective was to determine whether improving dietary quality and increasing physical activity levels improves HDL-CECs in men with abdominal obesity and dyslipidemia. Our study sample included men (48 ± 8.5 yr) with an elevated waist circumference (≥90 cm) associated with dyslipidemia (triglycerides ≥1...
October 1, 2018: American Journal of Physiology. Endocrinology and Metabolism
Robinson Ramírez-Vélez, María Correa-Rodríguez, Alejandra Tordecilla-Sanders, Viviana Aya-Aldana, Mikel Izquierdo, Jorge Enrique Correa-Bautista, Cristian Álvarez, Antonio Garcia-Hermoso
BACKGROUND: There is evidence to suggest that postprandial lipemia are is linked to the impairment of endothelial function, which is characterized by an imbalance between the actions of vasodilators and vasoconstrictors. The aim of this study was to determine the effects of a 12-week high-intensity training (HIT) and moderate continuous training (MCT) protocol on postprandial lipemia, vascular function and arterial stiffness in inactive adults after high-fat meal (HFM) ingestion. METHODS: A randomized clinical trial was conducted in 20 healthy, inactive adults (31...
April 3, 2018: Lipids in Health and Disease
Erik Ayala-Bribiesca, Sylvie L Turgeon, Geneviève Pilon, André Marette, Michel Britten
The aim of this study was to better understand the effect of calcium on the bioavailability of milk lipids from a cheese matrix using a rat model. Cheddar-type cheeses were manufactured with one of three types of anhydrous milk fat, control, olein or stearin, and salted with or without CaCl2 . The cheeses were fed to rats and postprandial lipemia was monitored. Feces were analyzed to quantify fatty acids excreted as calcium soaps. Higher calcium concentration in cheese caused a higher and faster triacylglycerol peak in blood, except for cheeses containing stearin...
May 2018: Food Research International
Kumari M Rathnayake, Michelle Weech, Kim G Jackson, Julie A Lovegrove
Background: Elevated postprandial triacylglycerol concentrations, impaired vascular function, and hypertension are important independent cardiovascular disease (CVD) risk factors in women. However, the effects of meal fat composition on postprandial lipemia and vascular function in postmenopausal women are unknown. Objective: This study investigated the impact of sequential meals rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), or n-6 (ω-6) polyunsaturated fatty acids (PUFAs) on postprandial flow-mediated dilatation (FMD; primary outcome measure), vascular function, and associated CVD risk biomarkers (secondary outcomes) in postmenopausal women...
March 1, 2018: Journal of Nutrition
Asım Orem, Serap Ozer Yaman, Buket Altinkaynak, Birgül Vanizor Kural, Fulya Balaban Yucesan, Yahya Altinkaynak, Cihan Orem
BACKGROUND: Postprandial triglyceride concentrations are clinically significant and independent predictor of cardiovascular disease risk. The purpose of this study was to determine postprandial TG ranges in healthy subjects by considering gender differences. Secondly, assess the relationship between postprandial lipemia and atherogenic indicators. Finally, investigate the use of the postprandial 4h TG test instead of the area under the curve (AUC). METHODS: Postprandial lipemia was investigated using the standardized oral fat tolerance test (OFTT) in 96 healthy subjects (45 female/51 male)...
May 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Mika Takeuchi, Ayaka Tsuboi, Miki Kurata, Tsutomu Kazumi, Keisuke Fukuo
BACKGROUND AND OBJECTIVES: To determine whether postprandial lipemia is associated with fat distribution even in young, normal weight women independently of fat mass, adipokines, insulin resistance and systemic inflammation. METHODS AND STUDY DESIGN: Female college students (ages 21-24, n=35) underwent dual-energy X-ray absorptiometry and a standardized breakfast providing 17 g triglycerides (TG). Serum lipids, lipoproteins, apolipoproteins, adipokines and markers of insulin resistance and inflammation were measured in fasting blood samples...
2018: Asia Pacific Journal of Clinical Nutrition
Tsung-Jen Yang, Chih-Hui Chiu, Mei-Hui Tseng, Cheng-Kang Chang, Ching-Lin Wu
Ingestion of low glycemic index (LGI) carbohydrate (CHO) before exercise induced less insulin response and higher fat oxidation than that of high GI (HGI) CHO during subsequent exercise. However, the effect on the subsequent postprandial lipid profile is still unclear. Therefore, the aim of this study was to investigate ingestion of CHO drinks with different GI using fructose and glucose before endurance exercise on the subsequent postprandial lipid profile. Eight healthy active males completed two experimental trials in randomized double-blind cross-over design...
January 29, 2018: Nutrients
Ann Bjørnshave, Jens Juul Holst, Kjeld Hermansen
Diabetic dyslipidemia with elevated postprandial triglyceride (TG) responses is characteristic in type 2 diabetes (T2D). Diet and meal timing can modify postprandial lipemia (PPL). The impact of a pre-meal of whey proteins (WP) on lipid metabolism is unidentified. We determined whether a WP pre-meal prior to a fat-rich meal influences TG and apolipoprotein B-48 (ApoB-48) responses differentially in patients with and without T2D. Two matched groups of 12 subjects with and without T2D accomplished an acute, randomized, cross-over trial...
January 25, 2018: Nutrients
Asim Orem, Serap Ozer Yaman, Buket Altinkaynak, Birgul Vanizor Kural, Fulya Balaban Yucesan, Yahya Altinkaynak, Cihan Orem
No abstract text is available yet for this article.
August 2017: Atherosclerosis
A Silveira, A Carlo, M Adam, O McLeod, P Lundman, S Boquist, B J Woodhams, A Hamsten
INTRODUCTION: Factor VII activation occurs postprandially. A proportion of activated factor VII (VIIa) circulates in complex with antithrombin (VIIaAT). Our primary objective was to assess the effects of postprandial lipemia on circulating VIIaAT, procoagulant phospholipid (PPL) activity, and thrombin generation. METHODS: Plasma samples from postmyocardial infarction patients (n = 40) and controls (n = 39) were taken before and at 3 and 6 hours during a standardized oral fat tolerance test (OFTT)...
June 2018: International Journal of Laboratory Hematology
Andreina Alfieri, Esther Imperlini, Ersilia Nigro, Daniela Vitucci, Stefania Orrù, Aurora Daniele, Pasqualina Buono, Annamaria Mancini
The position of the fatty acids ( sn -1, sn -2 and sn -3) (stereospecific numbering ( sn )) in triacylglycerol (TAG) molecules produces a characteristic stereospecificity that defines the physical properties of the fats and influences their absorption, metabolism and uptake into tissues. Fat interesterification is a process that implies a positional distribution of fatty acids (FAs) within the TAG molecules, generating new TAG species, without affecting the FA cis - trans natural balance. The interesterified (IE) fats, frequently used in the food industry comprise fats that are rich in long-chain saturated FAs, such as palmitic acid (16:0) and stearic acid (18:0)...
December 30, 2017: International Journal of Molecular Sciences
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