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Procalcitonin and antibiotic

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https://www.readbyqxmd.com/read/30315991/significance-of-the-detection-of-influenza-and-other-respiratory-viruses-for-antibiotic-stewardship-the-lessons-from-post-pandemic-period
#1
Tolga Taymaz, Önder Ergönül, Ayda Kebapcı, Rifat Okyay
OBJECTIVE: We aimed to describe the factors associated with antibiotic use in upper respiratory tract infections (URTI) in post-pandemic influenza period. METHODS: We included all the consecutive patients, who applied to emergency and outpatient departments with the symptoms of influenza like illness (ILI) between January and June 2011 in a private 265 bed hospital in Istanbul, Turkey. RESULTS: Out of 1270 patients, 100 were tested for Sreptocococcus A infection and 16 (16%) were found to be positive, 36 were tested for RSV and five patients were found to be positive...
October 10, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/30296418/adult-outpatients-with-acute-cough-due-to-suspected-pneumonia-or-influenza-chest-guideline-and-expert-panel-report
#2
Adam T Hill, Philip M Gold, Ali El Solh, Joshua P Metlay, Belinda Ireland, Richard S Irwin
BACKGROUND: Patients commonly present to primary care services with upper and lower respiratory tract infections and guidelines to help clinicians investigate and treat acute cough due to suspected pneumonia and influenza are needed. METHODS: A systematic search was carried out with eight PICO questions related to acute cough with suspected pneumonia or influenza. RESULTS: There was a lack of randomized controlled trials in the setting of outpatients presenting with acute cough due to suspected pneumonia or influenza that were not hospitalized...
October 5, 2018: Chest
https://www.readbyqxmd.com/read/30294770/correction-to-jeger-v-et-al-is-there-a-role-for-procalcitonin-in-differentiating-uncomplicated-and-complicated-diverticulitis-in-order-to-reduce-antibiotic-therapy
#3
Victor Jeger, Roxana Pop, Farschad Forudastan, Jean Pierre Barras, Markus Zuber, Rein Jan Piso
No abstract text is available yet for this article.
September 24, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/30268671/identifying-patients-with-bacterial-infections-using-a-combination-of-c-reactive-protein-procalcitonin-trail-and-ip-10-in-the-emergency-department-a-prospective-observational-cohort-study
#4
Yuri van der Does, Pleunie P M Rood, Christian Ramakers, Stephanie C E Schuit, Peter Patka, Eric C M van Gorp, Maarten Limper
OBJECTIVES: To effectively reduce the unnecessary use of broad spectrum antibiotics in the emergency department(ED), patients with bacterial infections need to be identified accurately. We investigated the diagnostic value of a combination of biomarkers for bacterial infections CRP and PCT, together with biomarkers for viral infections, TRAIL and IP-10, in identifying suspected and confirmed bacterial infections in a general ED population with fever. METHODS: This is a sub-study in the HiTEMP cohort...
September 27, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/30267624/association-of-serum-sphingomyelin-profile-with-clinical-outcomes-in-patients-with-lower-respiratory-tract-infections-results-of-an-observational-prospective-6-year-follow-up-study
#5
Giedre Zurauskaite, Thomas Baumgartner, Christian Steuer, Luca Bernasconi, Andreas Huber, Beat Mueller, Philipp Schuetz
Background Sphingolipids - the structural cell membrane components - and their metabolites are involved in signal transduction and participate in the regulation of immunity. We investigated the prognostic implications of sphingolipid metabolic profiling on mortality in a large cohort of patients with lower respiratory tract infections (LRTIs). Methods We measured 15 different sphingomyelin (SM) types in patients with LRTIs from a previous Swiss multicenter trial that examined the impact of procalcitonin-guided antibiotic therapy on total antibiotic use and rates and duration of hospitalization...
September 29, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/30267280/diagnostic-accuracy-of-procalcitonin-for-early-aspiration-pneumonia-in-critically-ill-patients-with-coma-a-prospective-study
#6
Stéphane Legriel, Benedicte Grigoresco, Patricia Martel, Matthieu Henry-Lagarrigue, Virginie Lvovschi, Gilles Troché, Marlène Amara, Gwenaelle Jacq, Fabrice Bruneel, Maguy Bernard, Anne Marinier, Jean-Pierre Bedos
BACKGROUND: Early diagnostic orientation for differentiating pneumonia from pneumonitis at the early stage after aspiration would be valuable to avoid unnecessary antibiotic therapy. We assessed the accuracy of procalcitonin (PCT) in diagnosing aspiration pneumonia (AP) in intensive care unit (ICU) patients requiring mechanical ventilation after out-of-hospital coma. METHODS: Prospective observational 2-year cohort study in a medical-surgical ICU. PCT, C-reactive protein (CRP) and white blood cell count (WBC) were measured at admission (H0) and 6 h (H), H12, H24, H48, H96, and H120 after inclusion...
September 28, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/30253454/peculiar-clinical-features-of-cellulitis-in-peripheral-lymphedema
#7
K Suehiro, N Morikage, K Ueda, M Samura, Y Takeuchi, T Nagase, T Mizoguchi, K Hamano
Although the occurrence of cellulitis in lymphedema (LE) is believed to be an infection-related event, many findings in its clinical course seem to suggest that it is unlikely to be an infection. Therefore, we tried to clarify the specific features of cellulitis in LE. In-hospital courses of cellulitis obtained from medical charts were reviewed in the patients with leg LE (LE; 24 patients, 72admissions), chronic venous insufficiency (CVI; 28 patients, 29 admissions), and leg cellulitis secondary to wound infection without underlying disease (N; 42 patients, 42 admissions)...
2018: Lymphology
https://www.readbyqxmd.com/read/30235108/is-procalcitonin-biomarker-guided-antibiotic-therapy-a-cost-effective-approach-to-reduce-antibiotic-resistant-and-clostridium-difficile-infections-in-hospitalized-patients
#8
Lotte Steuten, Janne Mewes, Isabelle Lepage-Nefkens, Hubertus Vrijhoef
Antibiotics (AB) can reduce morbidity and mortality in the treatment of patients with sepsis and chronic obstructive pulmonary disease (COPD) exacerbations. Yet, AB overuse or misuse increases antibiotic resistance (ABR) and Clostridium difficile infections (CDI). This study projected the expected impact of a procalcitonin (PCT) biomarker testing strategy on incremental ABR cases and CDI, and costs of care in a population of patients hospitalized with suspected sepsis or a COPD exacerbation, in three European countries: the United Kingdom, Germany, and the Netherlands...
September 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/30215959/procalcitonin-to-guide-antibiotic-therapy-in-acute-respiratory-infections
#9
Christopher E Jonas, Francesca Cimino, Chad Hulsopple
No abstract text is available yet for this article.
July 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/30190753/neutrophil-to-lymphocyte-ratio-and-mean-platelet-volume-can-be-useful-markers-to-predict-sepsis-in-children
#10
Adem Dursun, Serkan Ozsoylu, Basak Nur Akyildiz
Objectives: Neutrophil-to-Lymphocyte Ratio (NLR) and Mean Platelet Volume (MPV) have been found to be useful indexes for the diagnosis of sepsis in adults. However, the knowledge of their roles and cut-off values in pediatric patients is limited. The primary objective of this study was to assess the ability of NLR and MPV to predict sepsis in children. A secondary aim was to evaluate the comparison of these parameters with C-reactive Protein (CRP). Methods: The study was conducted on pediatric patients, who had two or more of the following criteria were included in the study: tachycardia, tachypnea, temperature change, leukocytosis, or leukopenia for age...
July 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/30143413/the-value-of-serum-procalcitonin-in-acute-meningitis-in-children
#11
Hatem H El Shorbagy, Naglaa Fathy Barseem, Waleed E Abdelghani, Hany A Suliman, Ashraf H Al-Shokary, Akram E Elsadek, Yehia H Abdel Maksoud, Jehan H Sabri
Early diagnosis and initial therapy are important to reduce the complications of bacterial meningitis. We aimed to evaluate the diagnostic value of serum procalcitonin in children with acute meningitis. We included 40 children (4 months-14 years) suspected to have acute meningitis in our study. Based on the clinical scenario, physical examination and complete analysis of cerebrospinal fluid, patients were assigned into two groups: bacterial meningitis group (24 patients) and aseptic meningitis group (16 patients)...
August 21, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/30137640/blood-procalcitonin-levels-and-duration-of-antibiotics-in-neonatal-sepsis
#12
N B Mathur, Bijaylaxmi Behera
Objective: To determine the time to normalization of procalcitonin (PCT) levels and duration of antibiotics in neonatal sepsis. Methods: A prospective observational study design was used. The participants included were neonates with sepsis. The primary outcome measure was time to normalization of PCT levels and duration of antibiotics following clinical resolution. Results: Time to normalization of PCT levels was 9.6 ± 4.2 days in neonates with septic shock, 6...
August 22, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/30124483/do-we-need-biomarkers-for-the-follow-up-and-shortening-of-antibiotic-treatment-duration
#13
Milagros Dianti, Carlos M Luna
PURPOSE OF REVIEW: Clinical and laboratory parameters are useful tools for the diagnosis, follow-up and evaluation of resolution, and to predict outcomes when measured at different time-points onset and serially during follow-up in patients with hospital-acquired pneumonia and/or ventilator-associated pneumonia (HAP/VAP). RECENT FINDINGS: Both, the 2017 ERS/ESICM/ESCMID/Asociación Latino Americana de Tórax (EEEAG) and the 2016 IDSA/ATS guidelines (IAG) for the management of HAP/VAP recommend using clinical criteria alone, rather than biomarkers for diagnosis...
October 2018: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/30111925/resurgence-of-global-opportunistic-multidrug-resistant-stenotrophomonas-maltophilia
#14
Pradheer Gupta, Pratibha Kale, Vikas Khillan
Context: Stenotrophomonas maltophilia is a known nosocomial pathogen which is intrinsically resistant to multiple antibiotics. In India, S. maltophilia infection has only few case reports. Aim: To determine the incidence of S. maltophilia infection from clinical isolates based on the specimen type, antibiotic susceptibility pattern, and impact on outcome. Settings and Design: One-year retrospective study was done at a tertiary liver care center...
July 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/30111341/effect-of-procalcitonin-guided-antibiotic-treatment-on-clinical-outcomes-in-intensive-care-unit-patients-with-infection-and-sepsis-patients-a-patient-level-meta-analysis-of-randomized-trials
#15
REVIEW
Yannick Wirz, Marc A Meier, Lila Bouadma, Charles E Luyt, Michel Wolff, Jean Chastre, Florence Tubach, Stefan Schroeder, Vandack Nobre, Djillali Annane, Konrad Reinhart, Pierre Damas, Maarten Nijsten, Arezoo Shajiei, Dylan W deLange, Rodrigo O Deliberato, Carolina F Oliveira, Yahya Shehabi, Jos A H van Oers, Albertus Beishuizen, Armand R J Girbes, Evelien de Jong, Beat Mueller, Philipp Schuetz
BACKGROUND: The clinical utility of serum procalcitonin levels in guiding antibiotic treatment decisions in patients with sepsis remains unclear. This patient-level meta-analysis based on 11 randomized trials investigates the impact of procalcitonin-guided antibiotic therapy on mortality in intensive care unit (ICU) patients with infection, both overall and stratified according to sepsis definition, severity, and type of infection. METHODS: For this meta-analysis focusing on procalcitonin-guided antibiotic management in critically ill patients with sepsis of any type, in February 2018 we updated the database of a previous individual patient data meta-analysis which was limited to patients with respiratory infections only...
August 15, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/30102716/mid-regional-pro-adrenomedullin-for-the-prediction-of-organ-failure-in-infection-results-from-a-single-centre-study
#16
Bruno Viaggi, Daniele Poole, Omar Tujjar, Silvia Marchiani, Agostino Ognibene, Stefano Finazzi
Biomarkers are widely used to confirm the presence of infection. However, it would be of the greatest importance to predict in advance the occurrence or worsening of organ dysfunction in infected patients allowing timely antibiotic escalation. This study investigates the ability of procalcitonin (PCT) and MR-proADM to predict the transition to sepsis in infected patients. The study was conducted in a neurointensive care unit over a three-month period. We included both patients with and without infection to investigate the specificity of organ dysfunction prediction in infected patients...
2018: PloS One
https://www.readbyqxmd.com/read/30060751/the-petechiae-in-children-pic-study-evaluating-potential-clinical-decision-rules-for-the-management-of-feverish-children-with-non-blanching-rashes-including-the-role-of-point-of-care-testing-for-procalcitonin-neisseria-meningitidis-dna-a-study-protocol
#17
Thomas Waterfield, Mark D Lyttle, Derek Fairley, James Mckenna, Kerry Woolfall, Fiona Lynn, Julie-Ann Maney, Damian Roland, Aoife Weir, Michael D Shields
BACKGROUND: Children commonly present to Emergency Departments (ED) with a non-blanching rash in the context of a feverish illness. While most have a self-limiting viral illness, this combination of features potentially represents invasive serious bacterial infection, including meningococcal septicaemia. A paucity of definitive diagnostic testing creates diagnostic uncertainty for clinicians; a safe approach mandates children without invasive disease are often admitted and treated with broad-spectrum antibiotics...
July 30, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/30054447/procalcitonin-guided-decision-making-results-in-a-significant-reduction-of-antibiotic-therapy-and-hospital-stay-in-neonates-with-suspected-early-onset-sepsis
#18
REVIEW
Meret Merker, Rebekka Bolliger, Philipp Schuetz
No abstract text is available yet for this article.
August 2018: BMJ evidence-based medicine
https://www.readbyqxmd.com/read/30051724/procalcitonin-and-cellulitis-correlation-of-procalcitonin-blood-levels-with-measurements-of-severity-and-outcome-in-patients-with-limb-cellulitis
#19
R J Brindle, A Ijaz, P Davies
BACKGROUND: Procalcitonin levels may be raised in bacterial infections and have been used to guide antibiotic therapy. There is little data on procalcitonin and limb cellulitis. OBJECTIVES: Within a clinical trial of antibiotic therapy, we examined the correlation between clinical observations, blood tests and local measurements of skin damage, with serum procalcitonin levels. METHODS: The data is from a subset of the patients recruited into a clinical trial of antibiotic therapy for cellulitis (clindamycin for cellulitis, NCT01876628) whose procalcitonin levels were correlated with clinical and laboratory measurements...
August 23, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30043056/procalcitonin-to-guide-antibiotic-decisions-reply
#20
LETTER
Philipp Schuetz, Beat Mueller
No abstract text is available yet for this article.
July 24, 2018: JAMA: the Journal of the American Medical Association
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