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Shu-Chun Lin, Li-Han Lin, Ssu-Yu Yu, Shou-Yen Kao, Kuo-Wei Chang, Hui-Wen Cheng, Chung-Ji Liu
In recent years, the incidence and mortality rates of head and neck squamous cell carcinoma (HNSCC) have increased worldwide. Therefore, understanding genomic alterations in HNSCC carcinogenesis is crucial for appropriate diagnosis and therapy. Procadherin FAT1, which encodes 4588 amino acid residues, regulates complex mechanisms to promote oncogenesis or suppression of malignancies. Multiplex polymerase chain reaction (PCR)-based next-generation sequencing (NGS) revealed FAT1 somatic mutations. The clinicopathologic implications of FAT1 in HNSCC were investigated using expression assays, and the functional role of FAT1 in HNSCC pathogenesis was determined using ectopic expression and knockdown experiments...
August 9, 2018: Carcinogenesis
Edward Chia-Cheng Lai, Patrick Ryan, Yinghong Zhang, Martijn Schuemie, N Chantelle Hardy, Yukari Kamijima, Shinya Kimura, Kiyoshi Kubota, Kenneth Kc Man, Soo Yeon Cho, Rae Woong Park, Paul Stang, Chien-Chou Su, Ian Ck Wong, Yea-Huei Yang Kao, Soko Setoguchi
Objective: The goal of the Asian Pharmacoepidemiology Network is to study the effectiveness and safety of medications commonly used in Asia using databases from individual Asian countries. An efficient infrastructure to support multinational pharmacoepidemiologic studies is critical to this effort. Study design and setting: We converted data from the Japan Medical Data Center database, Taiwan's National Health Insurance Research Database, Hong Kong's Clinical Data Analysis and Reporting System, South Korea's Ajou University School of Medicine database, and the US Medicare 5% sample to the Observational Medical Outcome Partnership common data model (CDM)...
2018: Clinical Epidemiology
Marisa A Bartz-Kurycki, Kathryn T Anderson, Mary T Austin, Lillian S Kao, KuoJen Tsao, Kevin P Lally, Akemi L Kawaguchi
BACKGROUND: Down syndrome (DS) is a genetic condition associated with multiple comorbidities. While physicians may perceive that DS patients have more postoperative complications, the literature remains unclear. This study compared postoperative complications for children with and without DS who underwent abdominal and thoracic procedures. METHODS: The National Surgical Quality Improvement Program Pediatric was queried for patients aged <18 years, who underwent abdominal and noncardiac thoracic operations (by Current Procedural Terminology codes) from 2012 to 2015...
October 2018: Journal of Surgical Research
N Capaldi, K T Kao, R MacDonald, K C Grainger, S Joseph, S Shepherd, A Mason, S C Wong
BACKGROUND: Interpretation of pediatric bone mineral density by dual energy absorptiometry (DXA) requires adjustment for height (Ht). This is often not easily obtainable in nonambulant subjects. AIMS: To investigate the feasibility of using DXA images to evaluate measurements of Ht, sitting height (SH), and leg length (LL). METHODOLOGY: A total of 2 observers performed measurements of Ht, SH, and LL on 3 separate occasion using DXA digital images in 125 children...
June 30, 2018: Journal of Clinical Densitometry
Jun-Jun Yeh, Cheng-Li Lin, Chia-Hung Kao
AIMS: To evaluate the relationship between cardiovascular diseases (CVDs) and pneumonia in the general population. METHODS: This retrospective observational study included two cohorts, namely CVD (n = 28,363) and non-CVD (n = 28,363) cohorts, which were matched by propensity score and examined for cases of pneumonia. Data were obtained from 2000 to 2011. In both cohorts, pneumonia risk was measured using multivariable Cox proportional hazard models. RESULTS: With the non-CVD cohort as reference, the corresponding adjusted hazard ratios (aHRs) [95% confidence intervals (CIs)] of pneumonia were 2...
August 8, 2018: European Journal of Internal Medicine
Dante De Paz, Kai-Ping Chang, Huang-Kai Kao, William Wei-Kai Lao, Yu-Chen Huang, Yu-Liang Chang, Yenlin Huang
OBJECTIVES/HYPOTHESIS: The role of tumor-associated tissue eosinophilia (TATE) in oral cavity cancer remains quite controversial. This study investigated the potential role of TATE in tongue squamous cell carcinoma (TSCC). STUDY DESIGN: Retrospective case series. METHODS: This study retrospectively enrolled 259 consecutive TSCC patients who underwent surgery between July 2004 and December 2015. Histopathological examinations for TATE in TSCC tumors were reviewed, and the association of TATE with different clinicopathological factors was evaluated...
August 10, 2018: Laryngoscope
Mingye Feng, Kristopher D Marjon, Fangfang Zhu, Rachel Weissman-Tsukamoto, Aaron Levett, Katie Sullivan, Kevin S Kao, Maxim Markovic, Paul A Bump, Hannah M Jackson, Timothy S Choi, Jing Chen, Allison M Banuelos, Jie Liu, Phung Gip, Lei Cheng, Denong Wang, Irving L Weissman
Macrophage-mediated programmed cell removal (PrCR) is a process essential for the clearance of unwanted (damaged, dysfunctional, aged, or harmful) cells. The detection and recognition of appropriate target cells by macrophages is a critical step for successful PrCR, but its molecular mechanisms have not been delineated. Here using the models of tissue turnover, cancer immunosurveillance, and hematopoietic stem cells, we show that unwanted cells such as aging neutrophils and living cancer cells are susceptible to "labeling" by secreted calreticulin (CRT) from macrophages, enabling their clearance through PrCR...
August 10, 2018: Nature Communications
Jui-Yin Kao, Ying-Ren Chen, Shen-Shin Chang
BACKGROUND: Though microvascular clamps are widely used for anastomosis training, there still have several shortcomings, including the bulging, expensiveness and unavailability due to sterilization. The aim of this study is to introduce a simple and novel microvascular training model without use of microvascular clamps. METHODS: Femoral vessels of Sprague Dawley rats training model were used to evaluate the usefulness of 4-0 silk as a slipknot for performing arterio-arterial and veno-venous microvascular anastomoses...
August 7, 2018: Asian Journal of Surgery
Hsiao-Chen Chiu, Meng-Yu Wu, Chao-Hsu Li, Su-Cheng Huang, Giou-Teng Yiang, Hsuan-Shang Yen, Wei-Lin Liu, Chia-Jung Li, Woei-Yau Kao
Disseminated peritoneal leiomyomatosis (DPL) is a rare condition that is characterized by the presence of multiple subperitoneal or peritoneal smooth muscle nodules of varying sizes on the omentum and peritoneal surfaces, grossly mimicking disseminated carcinoma. DPL usually develops in premenopausal women with a benign course, and it is often found incidentally during abdominal surgery. Malignant transformation is a rare clinical course of DPL. Only a few studies have focused on DPL transformation into a leiomyosarcoma...
August 9, 2018: Journal of Clinical Medicine
Chih-Hau Chang, Meng-Chi Yen, Ssu-Hui Liao, Yu-Ling Hsu, Chung-Sheng Lai, Kao-Ping Chang, Ya-Ling Hsu
We would like to submit the correction to our published paper [1]. [...].
August 9, 2018: International Journal of Molecular Sciences
Yi-Heng Lee, Hao-Chieh Hsu, Pei-Chen Kao, Young-Ji Shiao, Skye Hsin-Hsien Yeh, Feng-Shiun Shie, Shu-Meng Hsu, Chih-Wen Yeh, Hui-Kang Liu, Shi-Bing Yang, Huey-Jen Tsay
Alzheimer's disease (AD), a progressive neurodegenerative disease is highly associated with metabolic syndromes. We previously demonstrated that glycemic dysregulation and obesity are augmented in high fat diet (HFD)-treated APPswe/PS1dE9 (APP/PS1) transgenic mice. In the current study, the underlying mechanism mediating exacerbated metabolic stresses in HFD APP/PS1 transgenic mice was further examined. APP/PS1 mice developed insulin resistance and, consequently, impaired glucose homeostasis after 10 weeks on HFD...
August 8, 2018: International Journal of Molecular Sciences
Yu-Chia Kao, I-Fang Wang, Kuen-Jer Tsai
Microribonucleic acids (miRNAs) play a pivotal role in numerous aspects of the nervous system and are increasingly recognized as key regulators in neurodegenerative diseases. This study hypothesized that miR-34c, a miRNA expressed in mammalian hippocampi whose expression level can alter the hippocampal dendritic spine density, could induce memory impairment akin to that of patients with Alzheimer's disease (AD) in mice. In this study, we showed that miR-34c overexpression in hippocampal neurons negatively regulated dendritic length and spine density...
August 8, 2018: International Journal of Molecular Sciences
Lynn A Farrugia, Sean H Rhyee, Sharan L Campleman, Bryan Judge, Louise Kao, Anthony Pizon, Lauren Porter, Anne M Riederer, Timothy Wiegand, Diane Calello, Paul M Wax, Jeffrey Brent
The Toxicology Investigators Consortium (ToxIC) Case Registry was established by the American College of Medical Toxicology in 2010. The Registry collects data from participating sites with the agreement that all bedside medical toxicology consultations will be entered. The objective of this eighth annual report is to summarize the Registry's 2017 data and activity with its additional 7577 cases. Cases were identified for inclusion in this report by a query of the ToxIC database for any case entered from 1 January to 31 December 2017...
August 9, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
Chih-Sheng Chen, Hui-Man Cheng, Hsuan-Ju Chen, Shin-Yi Tsai, Chia-Hung Kao, Hui-Ju Lin, Lei Wan, Tse-Yen Yang
Background and Aim: The clinical association between dry eye syndrome (DES) and chronic fatigue syndrome (CFS) remain unclear with less evidences. We aimed to investigate the relationship between CFS and DES using a national insurance and prospective cohort study. Methods: Data from the Longitudinal Health Insurance Database 2000 was applied to estimate the incidence of CFS among patients with DES, and their age- and sex-matched controls without DES over a long-term follow-up period...
July 17, 2018: Oncotarget
Shang-Wen Chen, Wei-Chih Shen, Te-Chun Hsieh, Ji-An Liang, Yao-Ching Hung, Lian-Shung Yeh, Wei-Chun Chang, Wu-Chou Lin, Kuo-Yang Yen, Chia-Hung Kao
We retrospectively reviewed the records of 142 patients with stage IB-IIIB cervical cancer who underwent 18 F-FDG-PET/CT before external beam radiotherapy plus intracavitary brachytherapy and concurrent chemotherapy. The patients were divided into training and validation cohorts to confirm the reliability of predictors for recurrence. Kaplan-Meier analysis was performed and a Cox regression model was used to examine the effects of variables on overall survival (OS), progression-free survival (PFS), distant metastasis-free survival (DMFS), and pelvic relapse-free survival (PRFS)...
August 8, 2018: Scientific Reports
J-Y Peng, C-Y Chang, C-F Kao, Y-C Chang, C-S Hsueh, C-R Jeng, I-C Cheng, V F Pang, P-S Tsai, H-W Chang
The group 2b (G2b) porcine epidemic diarrhea virus (PEDV) that emerged in 2013 has since caused devastating diseases and economic loss. The full-length genome of the G2b Taiwan PEDV-Pintung 52 (PEDV-PT) strain and its intestinal tropism by evaluating the pathological changes in the original PEDV-PT infected field piglet and orally inoculation of either 10, 103 , or 105 50% tissue culture infective dose/mL (TCID50 /mL) of the plaque-purified PEDV-PT-Passage 5 (P5) in 7-day-old conventional piglets were analyzed...
July 2018: Veterinary Journal
Si-Kao Guo, Xiao-Xuan Shi, Peng-Ye Wang, Ping Xie
Kinesin-1 is a homodimeric motor protein that can move along microtubule filaments by hydrolyzing ATP with a high processivity. How the two motor domains are coordinated to achieve such high processivity is not clear. To address this issue, we computationally studied the run length of the dimer with our proposed model. The computational data quantitatively reproduced the puzzling experimental data, including the dramatically asymmetric character of the run length with respect to the direction of external load acting on the coiled-coil stalk, the enhancement of the run length by addition of phosphate, and the contrary features of the run length for different types of kinesin-1 with extensions of their neck linkers compared with those without extension of the neck linker...
August 2018: FEBS Open Bio
Chien-Ya Kao, Yen-Chieh Huang, Sheng-Yi Chiu, Ko-Liang Kuo, Pai-An Hwang
The addition of calcined waste clamshells (CCS) into polyethylene (PE) plastic bags imparts antibacterial properties due to the presence of CaO. In this study, different proportions of calcined waste clamshells were added to PE to explore its bacteriostatic effects. The PE plastic bags with 9% and 11% of CCS exhibited antibacterial efficacy. Further, total aerobic viable count (TVC) values for raw fish fillet packaging in 9% and 11% CCS-PE plastic bags for five days were similar to the 0% CCS-PE plastic bag group after three days of incubation...
August 7, 2018: Materials
Wei-Chan Hsu, Ming-Yu Chen, Shu-Ching Hsu, Li-Rung Huang, Cheng-Yuan Kao, Wen-Hui Cheng, Chien-Hsiung Pan, Ming-Sian Wu, Guann-Yi Yu, Ming-Shiu Hung, Chuen-Miin Leu, Tse-Hua Tan, Yu-Wen Su
Activated T cells undergo metabolic reprogramming and effector-cell differentiation but the factors involved are unclear. Utilizing mice lacking DUSP6 (DUSP6-/- ), we show that this phosphatase regulates T cell receptor (TCR) signaling to influence follicular helper T (TFH ) cell differentiation and T cell metabolism. In vitro, DUSP6-/- CD4+ TFH cells produced elevated IL-21. In vivo, TFH cells were increased in DUSP6-/- mice and in transgenic OTII-DUSP6-/- mice at steady state. After immunization, DUSP6-/- and OTII-DUSP6-/- mice generated more TFH cells and produced more antigen-specific IgG2 than controls...
August 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
Sibylle Mohr, Michael Deason, Mikhail Churakov, Thomas Doherty, Rowland R Kao
The movements of livestock between premises and markets can be characterised as a dynamic network where the structure of the network itself can critically impact the transmission dynamics of many infectious diseases. As evidenced by the 2001 foot-and-mouth disease (FMD) epidemic in the UK, this can involve transmission over large geographical distances and can result in major economic loss. One consequence of the FMD epidemic was the introduction of mandatory livestock movement restrictions: a 13-day standstill in Scotland for cattle and sheep after moving livestock onto a farm (allowing many exemptions) and a 6-day standstill for cattle and sheep in England and Wales (with minor exemptions, e...
September 1, 2018: Preventive Veterinary Medicine
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