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https://www.readbyqxmd.com/read/30316726/real-world-effectiveness-of-direct-acting-antiviral-agents-for-chronic-hepatitis-c-in-taiwan-real-world-data
#1
Chun-Ming Hong, Chen-Hua Liu, Tung-Hung Su, Hung-Chih Yang, Pei-Jer Chen, Yu-Wen Chen, Jia-Horng Kao, Chun-Jen Liu
BACKGROUND/PURPOSE: Treatment of chronic hepatitis C (CHC) has entered a new era since the introduction of direct-acting antiviral agents (DAAs). Numerous clinical trials have shown that treatment response as well as tolerability of DAAs are superior to those of conventional therapy with pegylated interferon and ribavirin. However, the results of clinical trials may not be directly applied to real-world practice. Therefore our study tried to investigate the effectiveness of various DAA regimens in Taiwanese patients with chronic hepatitis C...
September 26, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/30316128/uses-of-near-infrared-transmission-spectra-for-the-identification-of-hydrothermal-kaolinite-dickite-and-kaolinite-dickite
#2
Meng Lai, Zongting Liao, Zhengyu Zhou, Chiahsin Kao, Yingbo Li, Han Wang
X-ray diffraction (XRD) patterns and near-infrared (NIR) spectra have been evaluated and compared to differentiate hydrothermal kaolinite, dickite and kaolinite-dickite. The spectral bands were fitted for the first overtone and combination area of the infrared spectra of kaolinite, dickite and kaolinite-dickite, and the characteristic bands of kaolinite, dickite and kaolinite-dickite were obtained. The infrared spectra of kaolinite and dickite have obvious differences in the first overtone and combination area of OH bands...
October 2, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/30315862/new-phloroglucinol-derivatives-with-protein-tyrosine-phosphatase-1b-ptp1b-inhibitory-activities-from-syzygium-austroyunnanense
#3
Shao-Hua Xu, Wen Xu, Li Wang, Yi-Kao Hu, Jin-Ping Liu, Yan Zhao, Meng-Jia Li, Feng Li, Sheng-Xiong Huang, Yong Zhao
Five new phloroglucinol derivatives (1-5) together with one known analogue (6) were isolated from the leaves of Syzygium austroyunnanense which is an edible folk medicine used for the treatment of diabetes. The new structures were elucidated as austroyunones A - E (1-5) by means of the extensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR). Compounds 4-6 showed obvious protein tyrosine phosphatase 1B (PTP1B) inhibitory activity...
October 10, 2018: Fitoterapia
https://www.readbyqxmd.com/read/30314771/modeling-cost-effectiveness-of-risk-based-bovine-tuberculosis-surveillance-in-minnesota
#4
Szu-Yu Zoe Kao, Kimberly VanderWaal, Eva A Enns, Meggan E Craft, Julio Alvarez, Catalina Picasso, Scott J Wells
In the United States, slaughter surveillance combined with other measures has effectively maintained a very low prevalence of bovine tuberculosis (bTB). However, bTB continues to be sporadically detected, causing substantial economic burden to the government and cattle producers. To detect the infection earlier and reduce sudden economic losses, additional risk-based surveillance of live animals might be more cost-effective than slaughter surveillance alone to detect and prevent bTB infection. The objective of this study was to evaluate alternative risk-based surveillance strategies targeting high-risk herds to complement slaughter surveillance in a region with very low bTB prevalence...
November 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/30314398/intensive-periodontal-treatment-reduces-risks-of-hospitalization-for-cardiovascular-disease-and-all-cause-mortality-in-the-hemodialysis-population
#5
Shih-Ting Huang, Tung-Min Yu, Tai-Yuan Ke, Ming-Ju Wu, Ya-Wen Chuang, Chi-Yuan Li, Chih-Wei Chiu, Cheng-Li Lin, Wen-Miin Liang, Tzu-Chieh Chou, Chia-Hung Kao
Periodontal disease (POD) is associated with the risk of atherosclerotic vascular disease in patients on hemodialysis (HD). The association between POD treatment and cardiovascular diseases (CVDs) is still unknown. A total of 3613 patients who received HD and intensive POD treatment between 1 January 1998, and 31 December 2011 were identified from the National Health Insurance Research Database as the treatment cohort. The comparison cohort comprised patients without POD treatment who were matched to the patients in the treatment cohort at a 1:1 ratio by the propensity score...
October 11, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/30313049/what-happened-to-health-service-utilization-health-care-expenditures-and-quality-of-care-in-patients-with-acute-pancreatitis-after-implementation-of-global-budgeting-in-taiwan
#6
Ya-Lin Ko, Jyun-Wei Wang, Hui-Mei Hsu, Chia-Hung Kao, Chun-Yi Lin
AIM: Acute pancreatitis is associated with significant morbidity and mortality. In the United States, more than 3,00,000 patients are admitted and about 20,000 die from acute pancreatitis per year. In Taiwan, the incidence rate of acute pancreatitis is 0.03% and the mortality rate among severe acute pancreatitis is 16.3%. The aim of the study was to evaluate the impact of the global budgeting system on health service utilization, health care expenditures, and quality of care among patients with acute pancreatitis in Taiwan...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30312673/semen-parameters-amongst-transgender-women-with-a-history-of-hormonal-treatment
#7
Amanda J Adeleye, Garrett Reid, Chia-Ning Kao, Evelyn Mok-Lin, James F Smith
OBJECTIVE: To report on the semen quality parameters in transgender women who pursued semen cryopreservation either in the presence or absence of gender affirming hormonal medication. MATERIALS AND METHODS: This retrospective cohort study was conducted as a chart review of consecutive transgender women presenting for semen cryopreservation between January 1, 2012 and March 31, 2018. Demographic data and semen parameters were assessed. Primary outcomes were the semen parameters in subjects with either no exposure, previous exposure or current exposure to gender affirming hormonal medication RESULTS: Twenty-eight patients presented for semen cryopreservation and produced 69 specimens...
October 9, 2018: Urology
https://www.readbyqxmd.com/read/30311801/family-health-and-poverty-factors-impacting-suicide-attempts-in-cambodian-women
#8
Desiree M Seponski, Charity M Somo, Sovandara Kao, Cindy J Lahar, Sareth Khann, Tanja Schunert
BACKGROUND: Our recent report demonstrates that 5.5% of Cambodian women have previously attempted suicide. Despite these high rates and critical need for intervention, research on suicide attempts in Cambodia is lacking, and life-saving information on suicide prevention is therefore unknown. AIMS: This study explores factors impacting Cambodian women suicide attempts. METHOD: A total of 1,801 women participated in the large national survey during which 100 of these women (5...
October 12, 2018: Crisis
https://www.readbyqxmd.com/read/30309843/mr-venous-flow-in-sigmoid-sinus-diverticulum
#9
M R Amans, H Haraldsson, E Kao, S Kefayati, K Meisel, R Khangura, J Leach, N D Jani, F Faraji, M Ballweber, W Smith, D Saloner
BACKGROUND AND PURPOSE: Case reports demonstrate that coiling of a sigmoid sinus diverticulum can treat pulsatile tinnitus. We hypothesized that MR imaging 4D flow and computational fluid dynamics would reveal distinct blood flow patterns in the venous outflow tract in these patients. MATERIALS AND METHODS: Patients with pulsatile tinnitus of suspected venous etiology underwent MR imaging at 3T, using venous phase contrast-enhanced MR angiography, 4D flow, and 2D phase contrast...
October 11, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/30309750/a-rare-cause-of-hematochezia-after-colonoscopy
#10
Wei-Yu Kao, Cheng Tiong, Chun-Chao Chang
No abstract text is available yet for this article.
September 20, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/30309238/statin-and-the-risk-of-ischemic-stroke-or-transient-ischemic-attack-in-head-and-neck-cancer-patients-with-radiotherapy
#11
Bo-Ching Lee, Cheng-Li Lin, Hsin-Hsi Tsai, Chia-Hung Kao
No abstract text is available yet for this article.
September 2018: Journal of Stroke
https://www.readbyqxmd.com/read/30308702/comparative-population-genomics-reveals-key-barriers-to-dispersal-in-southern-ocean-penguins
#12
Gemma V Clucas, Jane L Younger, Damian Kao, Louise Emmerson, Colin Southwell, Barbara Wienecke, Alex D Rogers, Charles-André Bost, Gary D Miller, Michael J Polito, Patrick Lelliott, Jonathan Handley, Sarah Crofts, Richard A Phillips, Michael J Dunn, Karen J Miller, Tom Hart
The mechanisms that determine patterns of species dispersal are important factors in the production and maintenance of biodiversity. Understanding these mechanisms helps to forecast the responses of species to environmental change. Here we used a comparative framework and genome-wide data obtained through RAD-seq to compare the patterns of connectivity among breeding colonies for five penguin species with shared ancestry, overlapping distributions, and differing ecological niches, allowing an examination of the intrinsic and extrinsic barriers governing dispersal patterns...
October 11, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/30303611/phrenic-nerve-stimulation-to-treat-patients-with-central-sleep-apnoea-and-heart-failure
#13
Maria Rosa Costanzo, Piotr Ponikowski, Andrew Coats, Shahrokh Javaheri, Ralph Augostini, Lee R Goldberg, Richard Holcomb, Andrew Kao, Rami N Khayat, Olaf Oldenburg, Christoph Stellbrink, Scott McKane, William T Abraham
AIMS: The presence of central sleep apnoea (CSA) is associated with poor prognosis in patients with heart failure (HF). The aim of this analysis was to evaluate if using phrenic nerve stimulation to treat CSA in patients with CSA and HF was associated with changes in HF-specific metrics. METHODS AND RESULTS: All patients randomized in the remedē System Pivotal Trial and identified at baseline with HF were included (n = 96). Effectiveness data from treatment and former control groups were pooled based on months since therapy activation...
October 10, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/30301867/association-between-fine-particulate-matter-and-oral-cancer-among-taiwanese-men
#14
Yu-Hua Chu, Syuan-Wei Kao, Disline Manli Tantoh, Pei-Chieh Ko, Shou-Jen Lan, Yung-Po Liaw
The aim of this study was to investigate the association between fine particulate matter 2.5 (PM2.5 ) and oral cancer among Taiwanese men. Four linked data sources including the Taiwan Cancer Registry, Adult Preventive Medical Services Database, National Health Insurance Research Database, and Air Quality Monitoring Database were used. Concentrations of sulfur dioxide, carbon monoxide, ozone, NOx (nitrogen monoxide and nitrogen dioxide), coarse particulate matter (PM10-2.5 ) and PM2.5 in 2009 were assessed in quartiles...
October 9, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/30301771/quantification-of-hbv-core-antibodies-may-help-revisit-infectious-occult-hepatitis-b-virus
#15
Hung-Chih Yang, Jia-Horng Kao
No abstract text is available yet for this article.
October 9, 2018: Gut
https://www.readbyqxmd.com/read/30301580/quality-gaps-and-priorities-for-improvement-of-healthcare-service-for-patients-with-prolonged-mechanical-ventilation-in-the-view-of-family
#16
Bao-Lin Chang, Hsiu-O Kao, Shwu-Jen Lin, Shu-Hui Yang, Yao-Wen Kuo, Jih-Shuin Jerng
BACKGROUND: Little is known about the gaps between expectation and the perception of service quality in the care setting of prolonged mechanical ventilation (MV). METHODS: We conducted this prospective study at the Respiratory Care Center (RCC) of a medical center from February 2017 to January 2018. Family members of the patients admitted to the RCC completed a questionnaire based on the SERVQUAL instrument in two sections - expectation and perception, consisting of 22 questions each in five dimensions...
October 6, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/30301150/-ganoderma-tsugae-inhibits-the-srebp-1-ar-axis-leading-to-suppression-of-cell-growth-and-activation-of-apoptosis-in-prostate-cancer-cells
#17
Shih-Yin Huang, Guan-Jhong Huang, Hsi-Chin Wu, Ming-Ching Kao, Wen-Chin Huang
Recent research suggests that the activation of lipid biosynthesis (lipogenesis) is linked with prostate cancer (PCa) malignancy. Sterol regulatory element-binding protein-1 (SREBP-1) is a key transcriptional regulator controlling lipogenesis. Moreover, androgen receptor (AR) has been well defined to play an important role in lethal PCa aggressiveness from androgen-responsive to castration-resistant status. In this study, we showed that the quality-assured Ganoderma tsugae ethanol extract (GTEE), a Chinese natural and herbal product, significantly inhibited expression of SREBP-1 and its downstream genes associated with lipogenesis in PCa cells...
October 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30298000/-drynaria-fortunei-promoted-angiogenesis-associated-with-modified-mmp-2-timp-2-balance-and-activation-of-vegf-ligand-receptors-expression
#18
Sheng-Teng Huang, Cheng-Chieh Chang, Jong-Hwei S Pang, Hung-Sen Huang, Shen-Chieh Chou, Ming-Ching Kao, Huey-Ling You
Background and Purpose: Drynaria fortunei J. Sm ( D. fortunei ), known as Gu-Sui-Bu, is used in traditional Chinese medicine to treat common injuries, including bone fractures and bruising. The specific functional mechanisms of the angiogenic and endothelial cell migration properties of D. fortunei are currently unclear. Thus, the purpose of this study is to validate the potential angiogenic and cellular migration properties and related mechanisms by D. fortunei both in vivo and in vitro . Experimental Approach: The present study investigates, both in vivo and in vitro , the wound healing effects of D...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30297634/opposite-regulation-of-chop-and-grp78-and-synergistic-apoptosis-induction-by-selenium-yeast-and-fish-oil-via-ampk-activation-in-lung-adenocarcinoma-cells
#19
Ruey-Ho Kao, Gi-Ming Lai, Jyh-Ming Chow, Chien-Huang Liao, Yu-Mei Zheng, Wei-Lun Tsai, Simon Hsia, I-Chun Lai, Hsin-Lun Lee, Shuang-En Chuang, Jacqueline Whang-Peng, Chih-Jung Yao
Selenium has been intensively studied for the use of cancer prevention and treatment. However, the clinical effects are still plausible. To enhance its efficacy, a combinational study of selenium yeast (SY) and fish oil (FO) was performed in A549, CL1-0, H1299, HCC827 lung adenocarcinoma (LADC) cells to investigate the enhancement in apoptosis induction and underlying mechanism. By sulforhodamine B staining, Western blot and flow cytometric assays, we found a synergism between SY and FO in growth inhibition and apoptosis induction of LADC cells...
October 8, 2018: Nutrients
https://www.readbyqxmd.com/read/30297613/nb%C3%A2-o%C3%A2-and-ti-doped-nb%C3%A2-o%C3%A2-charge-trapping-nano-layers-applied-in-flash-memory
#20
Jer Chyi Wang, Chyuan Haur Kao, Chien Hung Wu, Chun Fu Lin, Chih Ju Lin
High-k material charge trapping nano-layers in flash memory applications have faster program/erase speeds and better data retention because of larger conduction band offsets and higher dielectric constants. In addition, Ti-doped high-k materials can improve memory device performance, such as leakage current reduction, k-value enhancement, and breakdown voltage increase. In this study, the structural and electrical properties of different annealing temperatures on the Nb₂O₅ and Ti-doped Nb₂O₅(TiNb₂O₇) materials used as charge-trapping nano-layers in metal-oxide-high k-oxide-semiconductor (MOHOS)-type memory were investigated using X-ray diffraction (XRD) and atomic force microscopy (AFM)...
October 8, 2018: Nanomaterials
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